GenomeNet

Database: Pfam
Entry: Taq-exonuc
LinkDB: Taq-exonuc
Original site: Taq-exonuc 
#=GF ID   Taq-exonuc
#=GF AC   PF09281.5
#=GF DE   Taq polymerase, exonuclease
#=GF AU   Sammut SJ
#=GF SE   pdb_1qtm
#=GF GA   25.00 25.00;
#=GF TC   76.00 74.10;
#=GF NC   21.90 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   10449720
#=GF RT   Structure-based design of Taq DNA polymerases with improved
#=GF RT   properties of dideoxynucleotide incorporation. 
#=GF RA   Li Y, Mitaxov V, Waksman G; 
#=GF RL   Proc Natl Acad Sci U S A. 1999;96:9491-9496.
#=GF DR   INTERPRO; IPR015361;
#=GF DR   SCOP; 1qtm; fa;
#=GF CC   Members of this family are found in prokaryotic Taq DNA
#=GF CC   polymerase, where they assume a ribonuclease H-like motif. The
#=GF CC   domain confers 5'-3' exonuclease activity to the polymerase [1].
#=GF SQ   36
#=GS D7BIB7_MEISD/305-434  AC D7BIB7.1
#=GS DPO1F_THETH/290-419   AC P30313.1
#=GS D7CT14_TRURR/333-458  AC D7CT14.1
#=GS H8GTN6_DEIGI/350-491  AC H8GTN6.1
#=GS E8PP18_THESS/289-418  AC E8PP18.1
#=GS DPO1_THECA/293-422    AC P80194.2
#=GS F6DGW7_THETG/290-419  AC F6DGW7.1
#=GS DPO1_DEIRA/408-547    AC P52027.2
#=GS E8U7Q0_DEIML/307-448  AC E8U7Q0.1
#=GS C1CWA2_DEIDV/376-514  AC C1CWA2.2
#=GS E8LAC8_9RHIZ/292-421  AC E8LAC8.1
#=GS Q58I34_THEAQ/13-142   AC Q58I34.1
#=GS Q1IXS3_DEIGD/360-498  AC Q1IXS3.1
#=GS B6VAJ2_9DEIN/293-422  AC B6VAJ2.1
#=GS Q72JS8_THET2/293-422  AC Q72JS8.1
#=GS B6VAJ4_9DEIN/290-419  AC B6VAJ4.1
#=GS B6VAJ3_9DEIN/293-422  AC B6VAJ3.1
#=GS Q6X9R2_THEFI/293-422  AC Q6X9R2.1
#=GS H9ZRE4_THETH/290-419  AC H9ZRE4.1
#=GS DPO1_THEAQ/291-420    AC P19821.1
#=GS DPO1_THEAQ/291-420    DR PDB; 4DF4 A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3T3F A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1QSY A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3OJS A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3PO5 A; 295-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3OJU A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1QTM A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1QSS A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3PY8 A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 4DFJ A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 4KTQ A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3SYZ A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3RTV A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3SV4 A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1TAQ A; 291-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 4DFM A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3M8S A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3PO4 A; 295-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3LWL A; 295-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 5KTQ A; 291-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3KTQ A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3RR7 A; 295-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1BGX T; 291-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 4DF8 A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 4DFK A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3SV3 A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3M8R A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3RRG A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 2KTQ A; 295-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1KTQ A; 291-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3LWM A; 295-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1JXE A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 4DFP A; 294-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3RR8 A; 293-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 1TAU A; 291-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3RRH A; 295-420;
#=GS DPO1_THEAQ/291-420    DR PDB; 3SZ2 A; 293-420;
#=GS E4U7R3_OCEP5/298-428  AC E4U7R3.1
#=GS DPO1_THEFI/293-422    AC O52225.1
#=GS B6VAJ1_9DEIN/293-422  AC B6VAJ1.1
#=GS DPO1T_THET8/293-422   AC P52028.2
#=GS B6VAJ5_9DEIN/293-422  AC B6VAJ5.1
#=GS F1LHM6_ASCSU/1-97     AC F1LHM6.1
#=GS B6VAI8_THES2/289-418  AC B6VAI8.1
#=GS B8QTI4_THETH/293-422  AC B8QTI4.1
#=GS G8N805_9DEIN/292-421  AC G8N805.1
#=GS D3PLE6_MEIRD/301-431  AC D3PLE6.1
#=GS H7GGF3_9DEIN/290-419  AC H7GGF3.1
#=GS F2NP76_MARHT/293-423  AC F2NP76.1
#=GS F0RN55_DEIPM/366-488  AC F0RN55.1
#=GS B6VAJ0_9DEIN/289-418  AC B6VAJ0.1
#=GS B6VAI9_9DEIN/291-420  AC B6VAI9.1
#=GS B7AAB4_THEAQ/291-420  AC B7AAB4.1
D7BIB7_MEISD/305-434             ............p-KPAEEAPWP.PPMGAFLGFTMDR.AQP..--MWAKLTGLAAAWDGKVY.RGPT....-----DLEELKGFHELSALAAKDLAVLAGKEGLDIPPGDDPMLLAYLYDPANSEPASTVRRYGAGDLVADPVSHAQAAWLLW-------etlsar
DPO1F_THETH/290-419              ............p-KAAEEAPWP.PPEGAFLGFSFSR.PEP..--MWAELLALAGAWEGRLH.RAQD....--PLRGLRDL---KGVRGILAKDLAVLALREGLDLFPEDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAGERALLAERLFQTLKERL......
D7CT14_TRURR/333-458             ....ledlffggs----------.------LGFVLSD.VSP..--MTGELLELAVAAGGAV-.-A-E....VPPERALELLRSEEVLHAADAKALAVYAQRCGLEVRPGDDPLLMAYVLDPSAADPETLTRRYGTPAWGATAVARAVATAELSRTLRPKL......
H8GTN6_DEIGI/350-491             ............t-EPDEWAALAvADPAPLFGELTRS.DKP..LTKTQQKAAEKATRDAEKR.AEKLr.qqYPATVDEAEFASQGTVTAAAAKALATHLSVRGTVTEPGDDPLLHAYLLDPANTNMPVTAQRYLGEGWPADAPGRAAMTARLLEALPGQL......
E8PP18_THESS/289-418             ...........pv--AAEEAPWP.PPEGAFVGYVLSR.PEP..--MWAELNALAAAWEGRVY.RAED....--PLEALRGL---GEVRGLLAKDLAVLALREGIALAPGDDPMLLAYLLDPSNTAPEGVARRY-GGEWTEEAGERALLSERLYAALLERL......
DPO1_THECA/293-422               ............p-APLEEAPWP.PPEGAFVGFVLSR.PEP..--MWAELKALAACRDGRVH.RAAD....--PLAGLKDL---KEVRGLLAKDLAVLASREGLDLVPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAHRALLSERLHRNLLKRL......
F6DGW7_THETG/290-419             ............p-APLEEAPWP.PPEGAFVGFVLSR.PEP..--MWAELKALAACRDGRVH.RAAD....--PLAGLKDL---KEVRGLLAKDLAVLASREGLDLVPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAHRALLSERLHRNLLKRL......
DPO1_DEIRA/408-547               ............s-EPDEWAQAE.APEN-LFGELLPS.DKP..LTKKEQKALEKAQKDAEKA.RAKLr.eqFPATVDEAEFVGQRTVTAAAAKALAAHLSVRGTVVEPGDDPLLYAYLLDPANTNMPVVAKRYLDREWPADAPTRAAITGHLLRELPPLL......
E8U7Q0_DEIML/307-448             ...........ga--PATEAWTT.PTEDAAWGYRLSR.EDE..LSAHLLDAATFGAEVARVA.PHASaeegATPSVDLSAFEGVRVVNAVNAKALATHLQVRGVSVEPGEDPLLIAYLLDNTVTNASLLAQAHLGAPWPDDAPTRALATAQLLTALRPQL......
C1CWA2_DEIDV/376-514             .....rlaetgvg----------.-PQTLFEGMLDPQgSAP..PTKAQLKAQEKARREAEKA.AAKLa.trYPDTVSEAEFIGQRAVTAAGAKALAAHLSVRGTVVDPGDDPLLHAYLLDPSNTTMATVTPRYLGVPWPADAAGRAAVTARLLRDLPPQL......
E8LAC8_9RHIZ/292-421             ...........pk--ALEEAPWP.PPEGAFVGFVLSR.KEP..--MWADLLALAAARGGRVH.RAPE....--PYKALRDL---KEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEEAGERAALSERLFANLWGRL......
Q58I34_THEAQ/13-142              ...........pk--ALEEAPWP.PPEGAFVGFVLSR.KEP..--MWADLLALAAARGGRVH.RAPE....--PYKALRDL---KEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEEAGERAALSERLFANLWGRL......
Q1IXS3_DEIGD/360-498             ......aeavavl-------DAA.APEGPLFGD-PPA.AAPrkLSKKAQQAAERAAQKAAER.RAAL....FPPIVSEAEFVGQREVTAAGAKALAAHLSVRGTVVEPGDDPLLVAYLLDPANTNMPIVAERYLRTTWPEDAATRAAITYRLLQDLPPHL......
B6VAJ2_9DEIN/293-422             .............EKPREEAPWP.PPEGAFVGFLLSR.KEP..--MWAELLALAAAAEGRVH.RATS....--PVEALADL---KEARGFLAKDLAVLALREGVALDPTDDPLLVAYLLDPANTNPEGVARRY-GGEFTEDAAERALLSERLFQNLFPRL......
Q72JS8_THET2/293-422             ............p-TPLEEAPWP.PPEGAFVGFVLSR.PEP..--MWAELKALAACRDGRVH.RAED....--PLAGLGDL---EEVRGLLAKDLAVLALREGLDLAPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAHRALLSERLHRNLLKRL......
B6VAJ4_9DEIN/290-419             ............p-APLEEAPWP.PPEGAFVGYVLSR.PEP..--MWAELKALAAAKEGRVH.RAED....--PLAGLRDL---KEVRGLLAKDLAVLALREGLDLPPSDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAQRALLAERLQQNLLERL......
B6VAJ3_9DEIN/293-422             .............EKPREEAPWP.PPEGAFVGFLLSR.KEP..--MWAELLALAAAAEGRVH.RATS....--PIEALADL---KEARGFLAKDLAVLALREGVALDPTDDPLLVAYLLDPANTNPEGVARRY-GGEFTEDAAERALLSERLFQNLFPRL......
Q6X9R2_THEFI/293-422             .............EKPREEAPWP.PPEGAFVGFLLSR.KEP..--MWAELLALAAAAEGRVH.RATS....--PVEALADL---KEARGFLAKDLAVLALREGVALDPTDDPLLVAYLLDPANTNPEGVARRY-GGEFTEDAAERALLSERLFQNLFPRL......
H9ZRE4_THETH/290-419             ............p-APLEEAPWP.PPEGAFVGFVLSR.PEP..--MWAELKALAACKEGRVH.RAAD....--PLAGLKDL---KEVRGLLAKDLAVLALREGLDLAPSDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAHRALLSERLHRNLLKRL......
DPO1_THEAQ/291-420               ...........pk--ALEEAPWP.PPEGAFVGFVLSR.KEP..--MWADLLALAAARGGRVH.RAPE....--PYKALRDL---KEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEEAGERAALSERLFANLWGRL......
#=GR DPO1_THEAQ/291-420    SS    ...........XS--SSEEEESS.--TT-EEEEEESS.SST..--TT--EEEEEEEETTEEE.EESS....--HHHHHTT----SSBBSTTHHHHHHHHHHTT----B---HHHHHHHH-TT--SHHHHHHHH-TS---SSHHHHHHHHHHHHHHHHHHT......
E4U7R3_OCEP5/298-428             .........apea----QEAAWP.PPERAWLGYVFDR.PEP..--MWAELGQLAAAWDERVA.EGPA....--RALELERF---PQLDAVQAKDLTVWALREGVRARPGDDPLLLAYLYDPSNNQPASTVRRYGVGDWTDRARDRALAARWLWREMSDRL......
DPO1_THEFI/293-422               .............EKPREEAPWP.PPEGAFVGFLLSR.KEP..--MWAELLALAAASEGRVH.RATS....--PVEALADL---KEARGFLAKDLAVLALREGVALDPTDDPLLVAYLLDPANTHPEGVARRY-GGEFTEDAAERALLSERLFQNLFPRL......
B6VAJ1_9DEIN/293-422             .............EKPREEAPWP.PPEGAFVGFLLSR.KEP..--MWAELLALAAAAEGRVH.RATS....--PVEALADL---KEARGFLAKDLAVLALREGVALDPTDDPLLVAYLLDPANTHPEGVARRY-GGEFTEDAAERALLSERLFQTLFPRL......
DPO1T_THET8/293-422              ............p-APLEEAPWP.PPEGAFVGFVLSR.PEP..--MWAELKALAACRDGRVH.RAAD....--PLAGLKDL---KEVRGLLAKDLAVLASREGLDLVPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAHRALLSERLHRNLLKRL......
B6VAJ5_9DEIN/293-422             .............EKPREEAPWP.PPEGAFVGFLLSR.KEP..--MWAELLALAAAAEGRVH.RATS....--PVEALADL---KEARGFLAKDLAVLALREGVALDPTDDPLLVAYLLDPANTNPEGVARRY-GGEFTEDAAERALLSERLFQTLFPRL......
F1LHM6_ASCSU/1-97                .............----------.-------------.---..--MWADLLALAAARGGRVH.RAPE....--PYKALRDL---KEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEEAGERAALSERLF-------......
B6VAI8_THES2/289-418             ...........pk--EAEEAPWP.PPGGAFLGFLLSR.PEP..--MWAELLALAGAKEGRVH.RAED....--PVGALKDL---KEIRGLLAKDLSVLALREGREIPPGDDPMLLAYLLDPGNTNPEGVARRY-GGEWKEDAAARALLSERLWQALYPR-v.....
B8QTI4_THETH/293-422             ............p-APLEEAPWP.PPEGAFVGFVLSR.PEP..--MWAELKALAACRDGRVH.RAAD....--PLAGLKDL---KEVRGLLAKDLAVLASREGLDLVPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAHRALLSERLHQNLLKRL......
G8N805_9DEIN/292-421             ............p-KAAEEAPWP.PPPGAFVGYVLSR.PEP..--MWADLLALAAAQEGRVH.RAPE....--ALAGLRAL---GEVRGLLAKDLAVLALREGLEIPPGDDPMLLAYLLDPSNTSPEGVARRY-GGEWAEEAGERALLAERLQAALWARL......
D3PLE6_MEIRD/301-431             ..........ppa---AEEAPWP.PPPEAFLGYTLDR.AQP..--MWANWLGLAAYAGGKVY.RGQP....--SLQELKKF---PEIRSMVAKDLSVLALKEGVWVPPGDDPMLLAYLYDPSNSDPASTVRRYGAGDWGSDPGERAQAAHTLWETLQSR-i.....
H7GGF3_9DEIN/290-419             ............p-APLEEAPWP.PPEGAFVGFVLSR.PEP..--MWAELKALAACKEGRVH.RAKD....--PLAGLKDL---KEVRGLLAKDLAVLALREGLDLAPSDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEDAAHRALLAERLQQNLLERL......
F2NP76_MARHT/293-423             ...........ar--SAEEAPWP.PPPEAFLGYVLDR.PQP..--MWAELKGLAGAWEGRVA.RGPA....--RAKELARF---EAVHALQAKDLTVWARREGVRVQPGEDPLLLAYLYDPTNSDPAATVRRYGAGDWSEDPAARALAAAELWRILGERL......
F0RN55_DEIPM/366-488             pvpalpetpalfe----------.-------------.---..------LAAEAAPAAPKKRgKAKEpqpqADETVLTAALAG-QELDAAGAKALATWLSVRGGDVTPGDDPLLLAYLLDPANTAMPAVAKRYLDTDWPEDAGTRAAIAAQLLELLPPQL......
B6VAJ0_9DEIN/289-418             ...........pv--AAEEAPWP.PPEGAFVGYVLSR.PEP..--MWAELNALAAAWEGRVY.RAED....--PLEALRGL---GEVRGLLAKDLAVLALREGIALAPGDDPMLLAYLLDPSNTAPEGVARRY-GGEWTEEAGERALLSERLYAALLERL......
B6VAI9_9DEIN/291-420             ...........pk--ALEEAPWP.PPEGAFVGFVLSR.KEP..--MWADLLALAAAREGRVH.RAPE....--PYKALRDL---KEARGFLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEEAGERATLSERLFANLWGRL......
B7AAB4_THEAQ/291-420             ...........pk--ALEEAPWP.PPEGAFVGFVLSR.KEP..--MWADLLALAAAREGRVH.RAPE....--PYKALRDL---KEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY-GGEWTEEAGERAALSERLFANLWERL......
#=GC SS_cons                     ...........XS--SSEEEESS.--TT-EEEEEESS.SST..--TT--EEEEEEEETTEEE.EESS....--HHHHHTT----SSBBSTTHHHHHHHHHHTT----B---HHHHHHHH-TT--SHHHHHHHH-TS---SSHHHHHHHHHHHHHHHHHHT......
#=GC seq_cons                    ...............shEEAPWP.PPEGAFVGFlLSR.sEP....MWA-LhALAAAp-GRVH.RAss......PhtuLcDL...+ElRGlLAKDLAVLALREGlsLsPGDDPhLLAYLLDPSNTsPEGVARRY.GGEWTEDAucRALLoERLapsLh.RL......
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