GenomeNet

Database: Pfam
Entry: Taq-exonuc
LinkDB: Taq-exonuc
Original site: Taq-exonuc 
#=GF ID   Taq-exonuc
#=GF AC   PF09281.8
#=GF DE   Taq polymerase, exonuclease
#=GF AU   Sammut SJ
#=GF SE   pdb_1qtm
#=GF GA   25.00 25.00;
#=GF TC   25.20 25.10;
#=GF NC   20.30 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   10449720
#=GF RT   Structure-based design of Taq DNA polymerases with improved
#=GF RT   properties of dideoxynucleotide incorporation. 
#=GF RA   Li Y, Mitaxov V, Waksman G; 
#=GF RL   Proc Natl Acad Sci U S A. 1999;96:9491-9496.
#=GF DR   INTERPRO; IPR015361;
#=GF DR   SCOP; 1qtm; fa;
#=GF CC   Members of this family are found in prokaryotic Taq DNA
#=GF CC   polymerase, where they assume a ribonuclease H-like motif. The
#=GF CC   domain confers 5'-3' exonuclease activity to the polymerase [1].
#=GF SQ   17
#=GS A0A0A7KMK5_9DEIO/361-494  AC A0A0A7KMK5.1
#=GS DPO1T_THET8/296-422       AC P52028.2
#=GS E4U7R3_OCEP5/301-428      AC E4U7R3.1
#=GS L0A636_DEIPD/306-435      AC L0A636.1
#=GS F2NP76_MARHT/296-423      AC F2NP76.1
#=GS D3PLE6_MEIRD/304-431      AC D3PLE6.1
#=GS A0A0F7JS25_9DEIO/375-517  AC A0A0F7JS25.1
#=GS D7CT14_TRURR/325-458      AC D7CT14.1
#=GS F0RN55_DEIPM/322-488      AC F0RN55.1
#=GS H8GTN6_DEIGI/353-491      AC H8GTN6.1
#=GS D7BIB7_MEISD/308-435      AC D7BIB7.1
#=GS C1CWA2_DEIDV/384-514      AC C1CWA2.2
#=GS E8U7Q0_DEIML/309-448      AC E8U7Q0.1
#=GS Q1IXS3_DEIGD/308-370      AC Q1IXS3.1
#=GS Q1IXS3_DEIGD/364-498      AC Q1IXS3.1
#=GS DPO1_DEIRA/411-547        AC P52027.2
#=GS DPO1_DEIRA/363-413        AC P52027.2
A0A0A7KMK5_9DEIO/361-494             .......................kka---AEAAAP.PPNLFDt.....dQPLSKKEQKAAE---..KAQKDAEKALAKLHqqf.............................patVDDAEFIGQRQVNAAGAKALAAHLSVRGTVVEPGEDPLLMAYLLDPANMNMALVTKRYLNMAWPDDAPGRAAITARLLTDLPPQL.......
DPO1T_THET8/296-422                  .........................l-EEAPWPPP.EGAFVG.......FVLSRPEPMWAELKA.lAACRDGRVHRAADP...................................--LAGLKDLKEVRGLLAKDLAVLASREGLDLVPGDDPMLLAYLLDPSNTTPEGVARRYG-GEWTEDAAHRALLSERLHRNLLKRL.......
E4U7R3_OCEP5/301-428                 .........................a-QEAAWPPP.ERAWLG.......YVFDRPEPMWAELGQ.lAAAWDERVAEGPAR...................................--ALELERFPQLDAVQAKDLTVWALREGVRARPGDDPLLLAYLYDPSNNQPASTVRRYGVGDWTDRARDRALAARWLWREMSDRL.......
L0A636_DEIPD/306-435                 ........................pt--LAPWQTPtEGVIWG.......YRLTREDDLQAELAE..VATWDGEAARVLEQ...................................VELAEFVGQRSVNAINAKALATHLMVRGVNVLPGEDPMLMAYLIDSAVTTPQLACEKHLGHAWPDQAAGRAVAGGRLLDALQDKL.......
F2NP76_MARHT/296-423                 .........................a-EEAPWPPP.PEAFLG.......YVLDRPQPMWAELKG.lAGAWEGRVARGPAR...................................--AKELARFEAVHALQAKDLTVWARREGVRVQPGEDPLLLAYLYDPTNSDPAATVRRYGAGDWSEDPAARALAAAELWRILGERL.......
D3PLE6_MEIRD/304-431                 .........................a-EEAPWPPP.PEAFLG.......YTLDRAQPMWANWLG.lAAYAGGKVYRGQPS...................................--LQELKKFPEIRSMVAKDLSVLALKEGVWVPPGDDPMLLAYLYDPSNSDPASTVRRYGAGDWGSDPGERAQAAHTLWETLQSR-i......
A0A0F7JS25_9DEIO/375-517             tepaewrraeayaqpgglfdtpdepa---------.------.......APLTKTQQKAAE---..KARKEQEKAAAKLReqy.............................patVDDAQFVAQRTVTAAAAKALAAHLSVRGTQVEPGDDPLLMAYLLDPANTTMSAVTQRYLNVPWPDDAAGRAAITAQLLDLLPPLL.......
D7CT14_TRURR/325-458                 ..........rqsyrtarledlffgg---------.---SLG.......FVLSDVSPMTGELLE.lAVAAGGAVAEVPPE...................................RALELLRSEEVLHAADAKALAVYAQRCGLEVRPGDDPLLMAYVLDPSAADPETLTRRYGTPAWGATAVARAVATAELSRTLRPKL.......
F0RN55_DEIPM/322-488                 ..................etgewqap-----APEQaGQATWG.......YVLSREDDLTAELRG..AAWLDGRVARPVPAlpetpalfelaaeaapaapkkrgkakepqpqadetVLTAALAGQ-ELDAAGAKALATWLSVRGGDVTPGDDPLLLAYLLDPANTAMPAVAKRYLDTDWPEDAGTRAAIAAQLLELLPPQL.......
H8GTN6_DEIGI/353-491                 ..........................DEWAALAVAdPAPLFGelt.rsdKPLTKTQQKAAE---..KATRDAEKRAEKLRqqy.............................patVDEAEFASQGTVTAAAAKALATHLSVRGTVTEPGDDPLLHAYLLDPANTNMPVTAQRYLGEGWPADAPGRAAMTARLLEALPGQL.......
D7BIB7_MEISD/308-435                 .........................a-EEAPWPPP.MGAFLG.......FTMDRAQPMWAKLTG.lAAAWDGKVYRGPTD...................................--LEELKGFHELSALAAKDLAVLAGKEGLDIPPGDDPMLLAYLYDPANSEPASTVRRYGAGDLVADPVSHAQAAWLLWETLSAR-t......
C1CWA2_DEIDV/384-514                 .......pqtlfegmldpqgsapptk---------.------.......----------AQLKAqeKARREAEKAAAKLAtry.............................pdtVSEAEFIGQRAVTAAGAKALAAHLSVRGTVVDPGDDPLLHAYLLDPSNTTMATVTPRYLGVPWPADAAGRAAVTARLLRDLPPQL.......
E8U7Q0_DEIML/309-448                 .........................p-ATEAWTTPtEDAAWG.......YRLSREDELSAHLLD..AATFGAEVARVAPHasaee.........................gatpsVDLSAFEGVRVVNAVNAKALATHLQVRGVSVEPGEDPLLIAYLLDNTVTNASLLAQAHLGAPWPDDAPTRALATAQLLTALRPQL.......
Q1IXS3_DEIGD/308-370                 ........................pa--IAEWRTPgPDVTWG.......YVLSREDDLTADLIA..AATFDGQVARVAPV...................................-EERASHTAEAVAVLDA--------------------------------------------------------------------aa.....
Q1IXS3_DEIGD/364-498                 .....................avlda------AAP.EGPLFGdppaaapRKLSKKAQQAAE---..RAAQKAAERRAALFp................................piVSEAEFVGQREVTAAGAKALAAHLSVRGTVVEPGDDPLLVAYLLDPANTNMPIVAERYLRTTWPEDAATRAAITYRLLQDLPPHL.......
DPO1_DEIRA/411-547                   ..........................DEWAQAEA-.PENLFGell.psdKPLTKKEQKALE---..KAQKDAEKARAKLReqf.............................patVDEAEFVGQRTVTAAAAKALAAHLSVRGTVVEPGDDPLLYAYLLDPANTNMPVVAKRYLDREWPADAPTRAAITGHLLRELPPLL.......
DPO1_DEIRA/363-413                   .........................p-ELAEWQTPaEGAVWG.......YVLSREDDLTAALLA..AATFEDGVARPAP-...................................-------------------------------------------------------------------------------------vsepdew
#=GC seq_cons                        .........................s...A.h.sP..tshhG.......asLo+tp.htAELht..sAsh-ucsARst.p......................................tphhu.cpVsAhsAKsLAsahphcGs.VpPGDDPLLhAYLlDPuNos.sssscRYhsssWssDAssRAhhstpLhctL.spL.......
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