GenomeNet

Database: Pfam
Entry: TipAS
LinkDB: TipAS
Original site: TipAS 
#=GF ID   TipAS
#=GF AC   PF07739.11
#=GF DE   TipAS antibiotic-recognition domain
#=GF AU   Bateman A, Finn RD
#=GF SE   Pfam-B_8785 (release 14.0)
#=GF GA   23.70 23.70;
#=GF TC   23.70 23.70;
#=GF NC   23.60 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12682015
#=GF RT   Structural basis for antibiotic recognition by the TipA class of
#=GF RT   multidrug-resistance transcriptional regulators. 
#=GF RA   Kahmann JD, Sass HJ, Allan MG, Seto H, Thompson CJ, Grzesiek S; 
#=GF RL   EMBO J 2003;22:1824-1834.
#=GF DR   INTERPRO; IPR012925;
#=GF DR   SCOP; 1ny9; fa;
#=GF CC   This domain is found at the C-terminus of some MerR family
#=GF CC   transcription factors. The domain has an alpha-helical 
#=GF CC   globin-like fold [1]. The family includes Mta a central
#=GF CC   regulator of multidrug resistance in Bacillus subtilis.
#=GF SQ   822
#=GS C6LFE1_9FIRM/121-233      AC C6LFE1.1
#=GS G9WK54_9FIRM/129-240      AC G9WK54.1
#=GS Q186Z8_PEPD6/159-290      AC Q186Z8.1
#=GS I6XXG7_PROPF/129-250      AC I6XXG7.1
#=GS A0A0B5DE79_9CORY/128-239  AC A0A0B5DE79.1
#=GS Q8ET80_OCEIH/135-250      AC Q8ET80.1
#=GS R4KGI2_CLOPA/159-289      AC R4KGI2.1
#=GS C2X5M7_BACCE/78-196       AC C2X5M7.1
#=GS A0A0F0GSH2_9PSEU/1-108    AC A0A0F0GSH2.1
#=GS A8MEH9_ALKOO/131-249      AC A8MEH9.1
#=GS A0A0N0H719_THEVU/125-245  AC A0A0N0H719.1
#=GS D3Q6A7_STANL/145-260      AC D3Q6A7.1
#=GS H6LGN6_ACEWD/128-242      AC H6LGN6.1
#=GS E7MN97_9FIRM/127-238      AC E7MN97.1
#=GS I4D2L0_DESAJ/108-243      AC I4D2L0.1
#=GS D6A7M6_9ACTN/131-247      AC D6A7M6.1
#=GS F0SUR9_SYNGF/136-250      AC F0SUR9.1
#=GS R6JVQ6_9CLOT/131-250      AC R6JVQ6.1
#=GS A4VTA8_STRSY/124-197      AC A4VTA8.1
#=GS E9T247_RHOHA/131-248      AC E9T247.1
#=GS A0A059W5G1_STRA9/143-259  AC A0A059W5G1.1
#=GS A0A0D5VLF7_9BURK/237-336  AC A0A0D5VLF7.1
#=GS C6XSR3_PEDHD/138-256      AC C6XSR3.1
#=GS A0A089KQL6_9BACL/135-249  AC A0A089KQL6.1
#=GS A9WPQ7_RENSM/1-91         AC A9WPQ7.1
#=GS I6SVJ3_ENTHA/135-249      AC I6SVJ3.1
#=GS U5RY41_9CLOT/292-381      AC U5RY41.1
#=GS A0A0M2JGI2_9ACTN/131-247  AC A0A0M2JGI2.1
#=GS A0A0A1CZU8_9MICC/132-248  AC A0A0A1CZU8.1
#=GS R6PF37_9FIRM/136-251      AC R6PF37.1
#=GS B2TMQ3_CLOBB/135-249      AC B2TMQ3.1
#=GS F9Q2C0_STROR/129-240      AC F9Q2C0.1
#=GS F4F6F6_VERMA/131-247      AC F4F6F6.1
#=GS A0A0M2VUI9_9BACL/125-245  AC A0A0M2VUI9.1
#=GS J9REP7_9ACTN/135-250      AC J9REP7.1
#=GS S0KJK1_ENTAV/135-248      AC S0KJK1.1
#=GS R6NDJ1_9CLOT/124-239      AC R6NDJ1.1
#=GS A0QUF9_MYCS2/129-247      AC A0QUF9.1
#=GS K6D8K5_BACAZ/135-249      AC K6D8K5.1
#=GS K6TWB6_9CLOT/135-249      AC K6TWB6.1
#=GS F2I803_AERUA/20-131       AC F2I803.1
#=GS G7M0Y3_9CLOT/159-291      AC G7M0Y3.1
#=GS U2RGX8_9FIRM/135-250      AC U2RGX8.1
#=GS D1C932_SPHTD/146-263      AC D1C932.1
#=GS A0A0M2NHG6_9FIRM/145-259  AC A0A0M2NHG6.1
#=GS V5X686_MYCNE/133-247      AC V5X686.1
#=GS K0F122_9NOCA/155-270      AC K0F122.1
#=GS B9E9R5_MACCJ/133-248      AC B9E9R5.1
#=GS A0A0M8XYW8_9ACTN/131-247  AC A0A0M8XYW8.1
#=GS W5XVP9_9CORY/138-252      AC W5XVP9.1
#=GS R4KGI2_CLOPA/290-380      AC R4KGI2.1
#=GS A7GUG0_BACCN/130-238      AC A7GUG0.1
#=GS F9PGI4_9ACTO/161-276      AC F9PGI4.1
#=GS R7BFR9_9FIRM/128-243      AC R7BFR9.1
#=GS C8NID0_9LACT/129-240      AC C8NID0.1
#=GS A3DJE0_CLOTH/50-164       AC A3DJE0.1
#=GS E0S068_BUTPB/127-242      AC E0S068.1
#=GS G2FP82_9FIRM/141-244      AC G2FP82.1
#=GS R6RAS7_9FIRM/121-204      AC R6RAS7.1
#=GS D0BKK0_9LACT/129-240      AC D0BKK0.1
#=GS A0A0A2U9U5_9BACL/130-242  AC A0A0A2U9U5.1
#=GS I0DSG4_PROSM/244-338      AC I0DSG4.1
#=GS A0A0C9N5Z2_SPHPI/126-249  AC A0A0C9N5Z2.1
#=GS D4L163_9FIRM/1-51         AC D4L163.1
#=GS Q5ZV30_LEGPH/129-244      AC Q5ZV30.1
#=GS A0A0F7JTG2_9DEIO/137-253  AC A0A0F7JTG2.1
#=GS J9H6Z6_9ACTN/4-105        AC J9H6Z6.1
#=GS F3NLJ8_9ACTN/128-247      AC F3NLJ8.1
#=GS A0A0F4KRP4_9ACTN/64-180   AC A0A0F4KRP4.1
#=GS A0A0C2U2T6_BACBA/133-250  AC A0A0C2U2T6.1
#=GS A0A059WAJ3_STRA9/181-296  AC A0A059WAJ3.1
#=GS C8NHQ8_9LACT/127-238      AC C8NHQ8.1
#=GS A0A0M2S2W5_9ACTN/131-247  AC A0A0M2S2W5.1
#=GS D9R5M6_CLOSW/135-249      AC D9R5M6.1
#=GS R7I726_9FIRM/124-239      AC R7I726.1
#=GS T1ZDT3_STRIT/129-240      AC T1ZDT3.1
#=GS J7IMN6_DESMD/135-249      AC J7IMN6.1
#=GS K6DTX7_9BACI/135-249      AC K6DTX7.1
#=GS G2FWS4_9FIRM/3-99         AC G2FWS4.1
#=GS G4HH32_9BACL/131-245      AC G4HH32.1
#=GS C0ZYF5_RHOE4/142-262      AC C0ZYF5.1
#=GS B6GE32_9ACTN/22-137       AC B6GE32.1
#=GS A0A0F2PM42_9FIRM/126-240  AC A0A0F2PM42.1
#=GS G9RTZ6_9FIRM/135-250      AC G9RTZ6.1
#=GS A0A0F7N7L0_9ACTN/130-247  AC A0A0F7N7L0.1
#=GS A0A0D5EEW0_9BURK/127-213  AC A0A0D5EEW0.1
#=GS G2FS08_9FIRM/135-249      AC G2FS08.1
#=GS R7MMV2_9FIRM/129-245      AC R7MMV2.1
#=GS D9TC79_MICAI/131-247      AC D9TC79.1
#=GS E1M938_9STRE/18-129       AC E1M938.1
#=GS Q67PF0_SYMTH/133-247      AC Q67PF0.1
#=GS H5UMM6_9MICO/139-254      AC H5UMM6.1
#=GS E3PV68_CLOSD/129-237      AC E3PV68.1
#=GS G9YRR9_9FIRM/135-250      AC G9YRR9.1
#=GS C7NFV2_KYTSD/148-264      AC C7NFV2.1
#=GS A1UNC4_MYCSK/133-247      AC A1UNC4.1
#=GS D6XYD1_BACIE/135-248      AC D6XYD1.1
#=GS E6KRV2_9ACTO/135-250      AC E6KRV2.1
#=GS A6M0Z2_CLOB8/135-249      AC A6M0Z2.1
#=GS V6KDP5_STRRC/134-250      AC V6KDP5.1
#=GS A0A0N1G5Z4_9ACTN/135-248  AC A0A0N1G5Z4.1
#=GS A1S937_SHEAM/39-90        AC A1S937.1
#=GS R6BID2_9CLOT/128-242      AC R6BID2.1
#=GS A0A0A1D2F7_9MICC/152-272  AC A0A0A1D2F7.1
#=GS C8WL72_EGGLE/141-257      AC C8WL72.1
#=GS A0A0M9ZYR4_9NOCA/129-247  AC A0A0M9ZYR4.1
#=GS G9EPC7_9GAMM/117-247      AC G9EPC7.1
#=GS A0A0K2YH64_9NOCA/123-239  AC A0A0K2YH64.1
#=GS G8SMB8_ACTS5/10-123       AC G8SMB8.1
#=GS D4K3E3_9FIRM/124-239      AC D4K3E3.1
#=GS B5HYC8_9ACTN/131-247      AC B5HYC8.1
#=GS A0A070C3F9_BURCE/247-337  AC A0A070C3F9.1
#=GS G0FX82_AMYMS/127-237      AC G0FX82.1
#=GS D9RYL1_THEOJ/130-243      AC D9RYL1.1
#=GS A0A0G3BI61_9BURK/140-235  AC A0A0G3BI61.1
#=GS Q11SP4_CYTH3/132-250      AC Q11SP4.1
#=GS V9W755_9BACL/74-196       AC V9W755.1
#=GS Q8DY38_STRA5/123-235      AC Q8DY38.1
#=GS A0A089XZL1_9LACO/135-253  AC A0A089XZL1.1
#=GS F2R6G9_STRVP/139-253      AC F2R6G9.1
#=GS A8MM58_ALKOO/135-249      AC A8MM58.1
#=GS A0A0M9Y2Y6_9ACTN/132-251  AC A0A0M9Y2Y6.1
#=GS A0A0H4CI33_9ACTN/132-251  AC A0A0H4CI33.1
#=GS A0A094XEC8_BACAO/135-250  AC A0A094XEC8.1
#=GS E3GLV2_EUBLK/128-284      AC E3GLV2.1
#=GS R6ESL2_9FIRM/137-252      AC R6ESL2.1
#=GS I0K261_9BACT/133-251      AC I0K261.1
#=GS K4J0T8_BIFAP/139-253      AC K4J0T8.1
#=GS A0A0A1G160_9MYCO/116-230  AC A0A0A1G160.2
#=GS Q5Z3H6_NOCFA/134-251      AC Q5Z3H6.1
#=GS G5K7P6_9STRE/129-240      AC G5K7P6.1
#=GS A0A0N0I5N4_9BACI/131-245  AC A0A0N0I5N4.1
#=GS R6DKG0_9CLOT/132-246      AC R6DKG0.1
#=GS A0A060QC44_9PROT/143-255  AC A0A060QC44.1
#=GS R4T6Y3_AMYOR/132-248      AC R4T6Y3.1
#=GS A0A0M2W041_9BACL/135-249  AC A0A0M2W041.1
#=GS F9VJX7_ARTSS/1-69         AC F9VJX7.1
#=GS A0A090IZ28_9BACI/135-249  AC A0A090IZ28.1
#=GS A0A097II53_9CORY/127-238  AC A0A097II53.1
#=GS H6NBG0_9BACL/131-248      AC H6NBG0.1
#=GS B1C6A0_9FIRM/159-277      AC B1C6A0.1
#=GS A0A089LT27_9BACL/138-252  AC A0A089LT27.1
#=GS A0A089W542_9ENTR/128-231  AC A0A089W542.1
#=GS Q8DWA6_STRMU/125-243      AC Q8DWA6.1
#=GS Q9KFR9_BACHD/130-244      AC Q9KFR9.1
#=GS F2JGE0_CELLD/135-251      AC F2JGE0.1
#=GS A8MKF1_ALKOO/132-251      AC A8MKF1.1
#=GS H6RL86_BLASD/129-245      AC H6RL86.1
#=GS A0A0F2C3B0_9MICO/129-259  AC A0A0F2C3B0.1
#=GS A0A0D5EPD3_9BURK/247-337  AC A0A0D5EPD3.1
#=GS A0A0A1MFP6_9BACI/131-240  AC A0A0A1MFP6.1
#=GS K6WSU6_9MICO/157-273      AC K6WSU6.1
#=GS E6UB78_RUMA7/124-239      AC E6UB78.1
#=GS A0A0G3IS55_9MYCO/129-247  AC A0A0G3IS55.1
#=GS Q24YF4_DESHY/128-242      AC Q24YF4.1
#=GS G0FY56_AMYMS/127-246      AC G0FY56.1
#=GS E4NED4_KITSK/138-254      AC E4NED4.1
#=GS A0A0F0LMN2_9MICO/139-273  AC A0A0F0LMN2.1
#=GS F5SBV8_9BACL/135-249      AC F5SBV8.1
#=GS A0A0M2HFG2_9MICO/130-254  AC A0A0M2HFG2.1
#=GS C4IGB1_CLOBU/128-242      AC C4IGB1.1
#=GS R6WRY4_9FIRM/14-129       AC R6WRY4.1
#=GS G4HMW8_9BACL/135-249      AC G4HMW8.1
#=GS U2SS57_9FIRM/7-93         AC U2SS57.1
#=GS D4LAG1_RUMC1/124-239      AC D4LAG1.1
#=GS R6G124_9CLOT/135-249      AC R6G124.1
#=GS J0KMP3_9BURK/1-64         AC J0KMP3.1
#=GS C9Z0V2_STRSW/131-247      AC C9Z0V2.1
#=GS R6QNP8_9FIRM/131-288      AC R6QNP8.1
#=GS A0A0G2ZN11_9DELT/129-241  AC A0A0G2ZN11.1
#=GS R3W4H5_9ENTE/135-249      AC R3W4H5.1
#=GS TIPA_STRCO/131-247        AC P0A4T8.1
#=GS C5R9M2_WEIPA/135-249      AC C5R9M2.1
#=GS J4UK53_9FIRM/129-240      AC J4UK53.1
#=GS A0A0F7FVU4_9ACTN/147-261  AC A0A0F7FVU4.1
#=GS F9ED09_9ACTO/151-266      AC F9ED09.1
#=GS A0A0A7I8J3_9BIFI/124-238  AC A0A0A7I8J3.1
#=GS F0RJJ1_DEIPM/134-250      AC F0RJJ1.1
#=GS A0A0E3W3N6_9FIRM/135-249  AC A0A0E3W3N6.1
#=GS A0A0D1W880_ANEMI/135-249  AC A0A0D1W880.1
#=GS K0J1M5_AMPXN/45-153       AC K0J1M5.1
#=GS D2Q340_KRIFD/129-243      AC D2Q340.1
#=GS A0A0F4JVK0_9ACTN/131-247  AC A0A0F4JVK0.1
#=GS V5XTL2_ENTMU/135-249      AC V5XTL2.1
#=GS D2NNX6_ROTMD/143-257      AC D2NNX6.1
#=GS A0A0F0EI63_9MICO/131-247  AC A0A0F0EI63.1
#=GS J4UH30_9FIRM/129-240      AC J4UH30.1
#=GS A0A0M9YGX9_9ACTN/133-247  AC A0A0M9YGX9.1
#=GS F7KS05_9FIRM/137-252      AC F7KS05.1
#=GS A0A0H3J3S7_CLOPA/135-249  AC A0A0H3J3S7.1
#=GS A0A0M2PJW2_9BACI/116-245  AC A0A0M2PJW2.1
#=GS A5N5M3_CLOK5/306-396      AC A5N5M3.1
#=GS Q0SA90_RHOJR/134-249      AC Q0SA90.1
#=GS B1VT66_STRGG/137-249      AC B1VT66.1
#=GS A0A0B5AQM1_9BACL/135-249  AC A0A0B5AQM1.1
#=GS C0ZE86_BREBN/124-242      AC C0ZE86.1
#=GS E8JYP6_9STRE/129-240      AC E8JYP6.1
#=GS E0DHV0_9CORY/138-252      AC E0DHV0.1
#=GS A0A0M9VME0_9MICO/128-243  AC A0A0M9VME0.1
#=GS K8EE21_CARML/135-250      AC K8EE21.2
#=GS A0A0K2YL42_9NOCA/130-251  AC A0A0K2YL42.1
#=GS R5QBL6_9FIRM/135-250      AC R5QBL6.1
#=GS V5X9U7_MYCNE/129-247      AC V5X9U7.1
#=GS A0A0F6YL72_9DELT/128-243  AC A0A0F6YL72.1
#=GS D9QEM6_CORP2/131-245      AC D9QEM6.1
#=GS A0A0F5VUI9_9ACTN/131-247  AC A0A0F5VUI9.1
#=GS D4C1H4_PRORE/146-236      AC D4C1H4.1
#=GS F4D0U1_PSEUX/127-240      AC F4D0U1.1
#=GS A0A0A8B5B4_9ACTN/129-240  AC A0A0A8B5B4.1
#=GS A0A0M8Y4U1_9PSEU/146-261  AC A0A0M8Y4U1.1
#=GS A0A0N0JZT7_9SPHN/116-253  AC A0A0N0JZT7.1
#=GS A6LZ00_CLOB8/294-382      AC A6LZ00.1
#=GS J7LH61_NOCAA/129-242      AC J7LH61.1
#=GS A0A0H4KGI5_9BACI/135-249  AC A0A0H4KGI5.1
#=GS E8U4S1_DEIML/131-247      AC E8U4S1.1
#=GS A0A0N0HV80_9ACTN/131-247  AC A0A0N0HV80.1
#=GS A0A075JJN7_9BACI/130-242  AC A0A075JJN7.1
#=GS A9G076_SORC5/127-239      AC A9G076.1
#=GS S5VK45_STRC3/131-247      AC S5VK45.1
#=GS A0A0C2Y9I8_BACBA/130-242  AC A0A0C2Y9I8.1
#=GS Q08UK9_STIAD/1-37         AC Q08UK9.1
#=GS A0A087DHS8_9BIFI/131-245  AC A0A087DHS8.1
#=GS A0A0M8THI3_9ACTN/131-247  AC A0A0M8THI3.1
#=GS S0JSS9_9ENTE/135-249      AC S0JSS9.1
#=GS V6K0L9_STRNV/1-66         AC V6K0L9.1
#=GS A6TAP5_KLEP7/127-232      AC A6TAP5.1
#=GS A0A0F6A9H7_9GAMM/126-255  AC A0A0F6A9H7.1
#=GS A4FQS4_SACEN/129-245      AC A4FQS4.1
#=GS A0A0H4LCD0_9LACO/135-250  AC A0A0H4LCD0.1
#=GS K8W0A6_PRORE/146-238      AC K8W0A6.1
#=GS G7W819_DESOD/135-249      AC G7W819.1
#=GS A8MEK2_ALKOO/101-242      AC A8MEK2.1
#=GS R5ZA10_9ACTN/155-270      AC R5ZA10.1
#=GS Q24PL3_DESHY/135-249      AC Q24PL3.1
#=GS A0A0M2SX58_9BACI/135-249  AC A0A0M2SX58.1
#=GS R2SWP0_9ENTE/135-250      AC R2SWP0.1
#=GS E0E1K1_9FIRM/1-83         AC E0E1K1.1
#=GS A0A0M2PE25_9BACI/143-257  AC A0A0M2PE25.1
#=GS Q816A4_BACCR/130-238      AC Q816A4.1
#=GS D1A9A9_THECD/132-248      AC D1A9A9.1
#=GS X5DV95_9CORY/145-260      AC X5DV95.1
#=GS F0Z4T7_9CLOT/166-277      AC F0Z4T7.1
#=GS B7C972_9FIRM/126-241      AC B7C972.1
#=GS K9UQB9_9CHRO/130-242      AC K9UQB9.1
#=GS A0A0A1MA35_9BACI/135-250  AC A0A0A1MA35.1
#=GS A0A077ZD95_TRITR/78-191   AC A0A077ZD95.1
#=GS Q04D11_OENOB/137-255      AC Q04D11.1
#=GS B1C6N8_9FIRM/128-242      AC B1C6N8.1
#=GS L8EUV9_STRRM/139-247      AC L8EUV9.1
#=GS G4KQQ0_OSCVS/16-102       AC G4KQQ0.1
#=GS K6TSN4_9CLOT/132-244      AC K6TSN4.1
#=GS J1HKB8_9ACTO/147-262      AC J1HKB8.1
#=GS G0H9S8_CORVD/146-264      AC G0H9S8.1
#=GS D9R9I8_CLOSW/166-248      AC D9R9I8.1
#=GS A0A0E3K0Y1_CLOSL/133-303  AC A0A0E3K0Y1.1
#=GS A0A024QCQ3_9BACI/131-249  AC A0A024QCQ3.1
#=GS E8W8S8_STRFA/127-241      AC E8W8S8.1
#=GS L7LLB0_9ACTN/142-258      AC L7LLB0.1
#=GS H0DIH4_9STAP/126-240      AC H0DIH4.1
#=GS A0A0F0HJD5_9PSEU/134-247  AC A0A0F0HJD5.1
#=GS A0A0M1URY0_CLOSO/133-247  AC A0A0M1URY0.1
#=GS D3PX69_STANL/25-141       AC D3PX69.1
#=GS G2P1E6_STRVO/131-247      AC G2P1E6.1
#=GS R5QK12_9FIRM/14-129       AC R5QK12.1
#=GS A0A0M8Y3H8_9ACTN/127-241  AC A0A0M8Y3H8.1
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D7B301_NOCDD/143-257                 .........................................wp--RQARVVWGG...SA......................................QWAQFA....EQA.......AFR.TRE.Q....W...Q....SLSASMSALQFDLGDAL..DRG.V..VPGSPEA.DALVERHREVFS......HFFP..-...............LTRRMQVCLGRMFE......SD.PG...............FS..AHYDGI............R..AG....LASWFRRSID--e............................
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A0A0F2JE67_9FIRM/135-249             ...........................................YGKEIREKYGA...ET......................................-VNKSN....QKV.......KGM.SQE.Q....F...A....EVTKLGTEVIETLQAAF..KTG.D..-PAGELA.QKAADLHRQWLC......FYWD..S...............YTKEAHAGVAQMYV......DD.PR...............FT..AYYDEQ............Q..PG....TAKFLRDAVHIY.............................
#=GC SS_cons                         ...........................................T--HHHHH--X...XX......................................-XXXXX....XXX.......XXX.XXX.X....X...X....XXXXXXXXXXXXXXXXX..--X.X..XXXXXXX.XXXXXXXXXXXX......XXXX..X..............XXXXXXXXXXXXXXX......XX.XX...............XX..XXXXXX............X..XX....XXXXXXXXXXXX.............................
#=GC seq_cons                        ...........................................atpEspp+aGp...pt.......................................hppup....p+h.......tph.spp.c....h...p....phppchpplhpplspsh..ttG.t..sssuppu.pplsccappals......phah..p...............sshchatsLuchYl......sD.tR...............Fp..thh-ph............t..sG....hApalpcAlth..............................
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