GenomeNet

Database: Pfam
Entry: Vpu
LinkDB: Vpu
Original site: Vpu 
#=GF ID   Vpu
#=GF AC   PF00558.17
#=GF DE   Vpu protein
#=GF AU   Bateman A
#=GF SE   Swiss-Prot
#=GF GA   24.00 24.00;
#=GF TC   24.10 24.40;
#=GF NC   23.90 23.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Vpu
#=GF RN   [1]
#=GF RM   9338017
#=GF RT   Enhancement of retroviral production from packaging cell lines
#=GF RT   expressing the human immunodeficiency type 1 VPU gene. 
#=GF RA   Kobinger GP, Mouland AJ, Lalonde JP, Forget J, Cohen EA; 
#=GF RL   Gene Ther 1997;4:868-874.
#=GF RN   [2]
#=GF RM   7853484
#=GF RT   The human immunodeficiency virus type 1 Vpu protein specifically
#=GF RT   binds to the cytoplasmic domain of CD4: implications for the
#=GF RT   mechanism of degradation. 
#=GF RA   Bour S, Schubert U, Strebel K; 
#=GF RL   J Virol 1995;69:1510-1520.
#=GF RN   [3]
#=GF RM   9182993
#=GF RT   Secondary structure and tertiary fold of the human
#=GF RT   immunodeficiency virus protein U (Vpu) cytoplasmic domain in
#=GF RT   solution. 
#=GF RA   Willbold D, Hoffmann S, Rosch P; 
#=GF RL   Eur J Biochem 1997;245:581-588.
#=GF DR   INTERPRO; IPR008187;
#=GF DR   SCOP; 1vpu; fa;
#=GF DR   TC; 1.A.40;
#=GF CC   The Vpu protein contains an N-terminal transmembrane spanning
#=GF CC   region and a C-terminal cytoplasmic region. The HIV-1 Vpu
#=GF CC   protein stimulates virus production by enhancing  the release of
#=GF CC   viral particles from infected cells. The VPU protein binds
#=GF CC   specifically to CD4.
#=GF SQ   3
#=GS VPU_HV1H2/1-81       AC P05919.1
#=GS VPU_HV1H2/1-81       DR PDB; 2N29 A; 1-54;
#=GS K1QEQ8_CRAGI/25-101  AC K1QEQ8.1
#=GS K2AIN0_9BACT/1-83    AC K2AIN0.1
VPU_HV1H2/1-81                  qpip-----IVAIVALV...VAIIIAIVVWSI..VIIEYRKILRQRKIDRLIDRLIERAEDSGNESEGEISA-LVEMGVEMGHHAPWD--vddl....
#=GR VPU_HV1H2/1-81       SS    XXXX-----XXXXXXXX...XXXXXXXXXXXX..XXX-TTSS-SSGGGGGHHHHHHHHHHTTSS--HHHHHH-HHHHHHHTT-TTTTS--SS--....
K1QEQ8_CRAGI/25-101             ntav-----IVGVVAAV...VLAI-LVVVFII..VFKRTRTTKPKDEMQGSEKRIQEREENAH-LRNGSENTGLTNIYENKE--------tddkpvl.
K2AIN0_9BACT/1-83               ....MSKKSMIAVVIAIvviVLVILGVVLTKYtnVGLSYRKNRLHKQVDKRYAELSETYEASEAKDMLEAELDQNKLVS-----------dsyfdgea
#=GC SS_cons                    XXXX-----XXXXXXXX...XXXXXXXXXXXX..XXX-TTSS-SSGGGGGHHHHHHHHHHTTSS--HHHHHH-HHHHHHHTT-TTTTS--SS--....
#=GC seq_cons                   pshs.....IVAVVAAV...VLlIluVVVapI..VhlcYRKs+h++clD+phcRLpERtEsScsccpGEtsssLsclsspht........sDDhss..
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