GenomeNet

Database: Pfam
Entry: XhoI
LinkDB: XhoI
Original site: XhoI 
#=GF ID   XhoI
#=GF AC   PF04555.11
#=GF DE   Restriction endonuclease XhoI
#=GF AU   Kerrison ND
#=GF SE   DOMO:DM04409;
#=GF GA   25.00 25.00;
#=GF TC   29.10 28.30;
#=GF NC   24.40 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   XhoI
#=GF RN   [1]
#=GF RM   3001639
#=GF RT   Nucleotide sequence of the PaeR7 restriction/modification system
#=GF RT   and partial characterization of its protein products. 
#=GF RA   Theriault G, Roy PH, Howard KA, Benner JS, Brooks JE, Waters AF,
#=GF RA   Gingeras TR; 
#=GF RL   Nucleic Acids Res 1985;13:8441-8461.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR007636;
#=GF CC   This family consists of type II restriction enzymes
#=GF CC   (EC:3.1.21.4) that recognise the double-stranded sequence CTCGAG
#=GF CC   and cleave after C-1.
#=GF SQ   37
#=GS A0A0N0Z1C0_9ACTN/24-213  AC A0A0N0Z1C0.1
#=GS E8JLP0_9ACTO/28-220      AC E8JLP0.1
#=GS L0DSM3_THIND/1-47        AC L0DSM3.1
#=GS I5B2S0_9DELT/30-220      AC I5B2S0.1
#=GS Q72WR9_DESVH/29-220      AC Q72WR9.1
#=GS A7IAU1_METB6/22-209      AC A7IAU1.1
#=GS A4ALN4_9ACTN/1-71        AC A4ALN4.1
#=GS C4XNH9_DESMR/29-220      AC C4XNH9.1
#=GS A0A0A8ESJ4_9ACTN/21-210  AC A0A0A8ESJ4.1
#=GS K9TFW3_9CYAN/28-219      AC K9TFW3.1
#=GS G7WKS3_METH6/14-202      AC G7WKS3.1
#=GS A0A0N1LB67_9PROT/30-222  AC A0A0N1LB67.1
#=GS A4ALN1_9ACTN/24-210      AC A4ALN1.1
#=GS H2CG34_9LEPT/27-217      AC H2CG34.1
#=GS E6KUT0_9ACTO/27-215      AC E6KUT0.1
#=GS R5WYQ2_9FIRM/31-219      AC R5WYQ2.1
#=GS A0A0B2AN37_9ACTN/1-167   AC A0A0B2AN37.1
#=GS A0A0B5FRQ3_9DELT/29-220  AC A0A0B5FRQ3.1
#=GS D4CRF2_9FIRM/28-215      AC D4CRF2.1
#=GS A0A0A8ELA7_9ACTN/23-214  AC A0A0A8ELA7.1
#=GS Q7N3K6_PHOLL/29-220      AC Q7N3K6.1
#=GS C7M1D1_ACIFD/7-197       AC C7M1D1.1
#=GS R6EHT7_9BACE/21-208      AC R6EHT7.1
#=GS G2MQR7_9ARCH/25-214      AC G2MQR7.1
#=GS R6FJH8_9BACE/29-217      AC R6FJH8.1
#=GS K5Z1E7_9PROT/29-220      AC K5Z1E7.1
#=GS A0A0A8ENH9_9ACTN/24-158  AC A0A0A8ENH9.1
#=GS D5MMJ7_9BACT/31-221      AC D5MMJ7.1
#=GS A1WFA1_VEREI/29-125      AC A1WFA1.1
#=GS E0QQ27_9ACTO/23-205      AC E0QQ27.1
#=GS B3EK31_CHLPB/24-214      AC B3EK31.1
#=GS H6SPY2_RHOPH/37-226      AC H6SPY2.1
#=GS F4KTK4_HALH1/27-214      AC F4KTK4.1
#=GS A1BHP7_CHLPD/29-219      AC A1BHP7.1
#=GS R6PPH5_9BACT/21-209      AC R6PPH5.1
#=GS D8P7K3_9BACT/24-227      AC D8P7K3.1
#=GS K9VP54_9CYAN/30-224      AC K9VP54.1
A0A0N0Z1C0_9ACTN/24-213             .............nqsair-----EAVGAGTAG.SVRGGKHFDPVAALLAKFFLEAGYPPESIR..ISKRqgLE..LPG.YYRPQKQWDVVVAY..EDVLVAAFELKGLGGPSFG..NNYNNRVEEALGSAVDLRRAALADLY-PG.EKPWIGYFFIMQDEAESRRPVKL.A.K.GA.LPADSIWQG...............ASYQDRFGIFCERLVSEQLYDAVCYVTSSASE--------pkpte....
E8JLP0_9ACTO/28-220                 ..................r-QALRGDADRGGRG.QVTAGKNMDGFVHLIHDVADRAGLPKDSVL..VERR..AV.tLPG.FFRPSKSWDVTVVH..RGALLAVIEFKSQAGTSMG..NNFNNRSEEAVGSAYDLRCAYDEGLLGQI.DPPFIGWFMFVEENSASTRPHRD.G.T.QYlFEIDHVMRR...............GSYIDRYVELCQRLTATGLYTSCALVSAPASSITSGDFT-v........
L0DSM3_THIND/1-47                   ..................m--------------.------------------------------..----..--..---.--------------..-------------------..-----------------------------.-----------------------.-.-.--.---FSEFQG...............ASYPERYNILCQRLMQEQLYSAASIIASARTASADGAYV-e........
I5B2S0_9DELT/30-220                 ...................KQKKSGKVDYGLRG.AVTGGAQMDGFIELFARLIISTGLDAHFIQ..RKGA..LD..LPG.YFRPTKEWDLLVVK..DGKLIAAIEAKSQVGPSFG..NNFNNRTEEAMGSALDLWTAYREGAFHTS.PQPFLGYFFMLEDCQASTRPVRV.R.E.PH.FHVFPEFKG...............ASYMKRYEIFCRKLVLERHYTASAFITSNRTDGPEGIFS-t........
Q72WR9_DESVH/29-220                 ...................KQLESGKTDQGERA.GVTAGKNMDGFVELVLDIVRANGLAHADIH..QNKG..LL.tLPG.FFRPTKLWDLLVIS..EGQLIAAVEFKSQVGPSFG..NNFNNRAEEAIGTAHDFWTAYRDGAFGEQ.PRPFIGWLMLVEDAPASRAAVQE.C.S.PH.FPVFLEFKG...............ASYIKRYDILCQKLMHERLYTTASVIASPKNNCRLGQYS-s........
A7IAU1_METB6/22-209                 ...................KQTESGRHDQGTRG.AATGGAQMDAFADLICSAITEAGIPESAIF..QKTA..VE..LPG.YYRPEKKWDIVVVQ..KGVLGAVIELKSQMGPSFG..NNFNNRSEEALGSATDIWVAFREKRFGSRmFRPWLGYLFLLEDCPESTAPVAV.R.E.PH.FAIDEIFRD...............ASYKKRYEILCERLILERLYESSCFITARFE---------stdih....
A4ALN4_9ACTN/1-71                   ...................--------------.-------MDGFDTVIAGLVESNARDGAELS..KTRR..LN.tVPG.YFRVMKDRDLLVVR..KGALVAAIELESQVGPGFG..MNFPN------------------------.-----------------------.-.-.--.---------...............----------------------------------------.........
C4XNH9_DESMR/29-220                 ...................KQIESGKADQGERA.GVTGGKNMDGFIALVLDIVRANGLAHAEIH..QSRA..VL.tLPG.YFRPTKLWDLLVIF..KGELIAAIELKSHVGPSFG..NNFNNRTEEAIGTAHDLWTAYREEAFGKQ.PRPFVGWLMLVEDAPESRSPVRD.S.S.PH.FPVFPEFKG...............ASYLKRYDILCQRLVQEQLYTTAAVLTSPRSAAETGEVS-d........
A0A0A8ESJ4_9ACTN/21-210             ..............geqrd-----NQADGGKAGgEARANGHIKGFEAAVKGIFLDCDIPAGDIR..TGKP..Y-..LPG.YYRVRKQWDLVVLY..KEVLVAALEFKSQVG-SVG..KNFNNRFEEALGSATDLAAAQKKNGPFGA.VPPWLGYVFVLEETEETEKLNRQ.S.H.AL.FEIDPAFKG...............MSYTQRYQEMISRFVGENVYDIGWFITTQRAED-------gsityke..
K9TFW3_9CYAN/28-219                 ...................KQKMSIKQDYGARS.AVTGGKQMAAFERLATQIALDAGIPESSIF..WTSR..LE..LPG.YFRPEKKWDLLIVD..QGTLVAAVEFKSQVGPSFG..NNFNNRAEEAIGTAQDLWIAYREGVFGEQ.QQPWLGYLFILEDCDKTQVPVTA.K.Q.PH.FKVSPDFMN...............ASYAKRYEILLTKLVRERYYTSACLILSKKPQN-------iddihyse.
G7WKS3_METH6/14-202                 ..................d-QERRGGSDQGARS.AVTGGKQMDGFVRKIIELMTASGVDEGNIY..TKKT..H-..LPG.FFRPVKGWDIVVVV..DGVLMAAIELKSQVGLSFG..NNFNNRTEEAMGTALDIWTAYREGAFCTS.PAPWLGYLFLLEDCPESRSPVRT.Q.E.TH.FPVFEEFRG...............ASYAKRYELFCRKLVRERQYNAACFIIADREKSNS-----fesy.....
A0A0N1LB67_9PROT/30-222             .................qg--SKSGQKDAGSRG.AVTGGKHADGFVNMVADIVRSAGLADPEVRysAKRG..RT..LPG.YFRPSKEWDLVVIS..RGQLLAAVEIKSQVG-SFG..NNFNNRVEEALGNASDFWEAYSKGLYAPS.PEPWLGYLFMLEDADRANAPTKR.I.ElDE.FHVDEAFQS...............LSYAQRYEQVCLRLVRERRYQAACFFLSDKSSGKSGKFR-q........
A4ALN1_9ACTN/24-210                 ...................RQKEEGKKDAGAQA.R--NARHMKKLGTFVRQMFVNAGLSEADVM..VNGV..--..IPG.YFRRSKNWDVVATY..KGQLVALVELKSQVG-SND..SNGNNRIEEALGNPKDAATAQELNQVFGK.LPIWTAFGVVFGSSPENAKAVGLpS.N.PL.FPLDPVFNG...............MTYGRQWEIAIERFIQTGSYSAGWMVTSWVSA--------egqvkyve.
H2CG34_9LEPT/27-217                 ................kqg--EASGTKDAGNRS.SVTGGAQLDGFIELFAKIARDSGLTDSEIH..MKET..T-..LPG.YYRPTKEWDLVLYA..DGDLIASVEFKSHIGPSFG..NNFNNRVEEALGSATDLRTAYREGAMKQS.IKPWMGYFMLLEDHPKSATPVKV.R.E.PY.FPVLPDFKE...............ASYQRRYVEFCRRLVLEGLYDSACLLFSAESTGRSGDFTE.........
E6KUT0_9ACTO/27-215                 ..............nqggl----SGIKDTGNRA.AVTGGKQMDLMQAVVADLWMSDPEIHLEVR..TTGH..ND..LPT.YFRPSKNWDLVVLY..RGALIAAMEFKSQRGPSFG..NNFNNRTEEALGLAADSQMAVERGLFGI-.LKPWFGFIMLVERAVGSTRPVRV.PpN.MP.FPADPIFHG...............KSYIGRYRIFFERMIAEGNYDAVALLTAEANSGE------yqe......
R5WYQ2_9FIRM/31-219                 ...................KQDNSAVHDQGNRG.AVTGGKQLDGFVDLISEILIMNGVPKTSIF..TSSN..LE..LPG.FYRPNKKWDLLVVD..NNELVIAIEFKSQVGPSFG..NNFNNRTEEAMGSALDIWTAYREGVFGSQ.NAPWLGYFMVLEDCKKSTDPVNV.R.S.PH.FQVLDEFID...............ASYKDRYQIFCNKLLLERQYSAACFMTTSKGEN-------tnsya....
A0A0B2AN37_9ACTN/1-167              mdamqevvaklwrddpdit--------------.--------------------------LEVR..TTGH..NN..LPA.YFRPAKNWDLLVLY..RGSLIAAMEFKSQRGPSFG..NNFNNRTEEALGLAADSQMAVERGLFGQ-.LKPWFGFIMLVERAPGSLSAVKVpK.N.MP.FPADPIFEG...............ASYIGRYKIFFERMVKEGNYDAVALLTAES----------gsehfte..
A0A0B5FRQ3_9DELT/29-220             ...................KQIESGKADQGERA.SVTSGKNMDGFIALILDIIHANGLTHADIH..QKRA..VL.tLPG.FFRPTKLWDLLVIH..KGELIAAIELKSQVGPSFG..NNFNNRTEEAIGTAHDLWTAYREGAFGKQ.PRPFVGWLMLVEDAPESRSPVKY.N.S.PH.FPVFKEFKS...............VSYLQRYDLLCQKLTQEQLYTSASLIASPRSAAAGGNFC-s........
D4CRF2_9FIRM/28-215                 ...................RQNASGVHDQGNRG.AVTGGKQLDGFVDLIRDILLINGVPRECIF..TSSD..VE..LPG.YYRPNKKWDLLVVD..NNELVIAIEFKSQVGPSFG..NNFNNRTEEAMGGALDIWTAYREGVFGVQ.KAPWLGYFLVLEDCARSNEPVRV.R.S.PH.FPVLQEFVD...............ASYKERYEIFCSKLLLERQYSGACFTTTGVQE--------grify....
A0A0A8ELA7_9ACTN/23-214             ..........seqsaikaa-------VGAGTAG.SVRGGKHFDVIAALLAKFFLEAGYPAESIR..VSKS..QGleLPG.YYRPQKQWDLVVVH..EGVLVAAFEMKALGGPSYG..NNYNNRVEEALGSAVDLRRAALAELYP-K.EKPWLGYFFIMQDGEGSRRPVKT.A.K.GA.LPAGEIWHG...............TSYQDRFGIFCERLMAEQLYDAACYVTSSAET--------pkpiel...
Q7N3K6_PHOLL/29-220                 ...................KQIESGKADQGERA.GVTAGKNMDGFLALVLDIIKANGLAHAEIH..QNRA..ML.tLPG.YFRPTKLWDLLVLY..KGQLIAAIELKSQVGPSFG..NNFNNRTEEAIGTAHDLWTAFREEAFGKQ.PRPFVGWMMMVEDASESRKSVRD.S.S.PH.FPVFEEFKG...............ASYLKRYDLLCQRLVQEQLYTTAAVIAAERSAVNTGDFAE.........
C7M1D1_ACIFD/7-197                  ...........qtvkqmgg--------SAGTRG.AVTGGAQMGALEVLLTDVLVDAGLEPDHVR..VRTA..LE..LPG.YYRPERKWDLLVVV..DGQLLVAVEFKSQVGPSFG..NNFNNRTEEAIGNAEDIWTAYREGRFGKH.PAPFLGYFFLLEDCAKVHAPVRN.V.E.PY.FPVDPIFAG...............ASYAKRYEVLCDRLVLERKYSAGCLTLATNSKPTKVT---fps......
R6EHT7_9BACE/21-208                 ...............kqkq---LSASNESSNRG.AVVGGKQLDAFADLLRTIAIEQGVPEACIY..TKQA..Y-..LPG.YFRSSKDWDFLIIA.pNKKLIAAIELKSQIG-SYG..NNLNNRAEEAIGSAVDLWTAFRENQFPDQ.TAPWIGYLTIVGKDEKSTCAIRN.N.E.PH.YSVLPEFKN...............ASYLDRYRILCQKLILERHYSMAALICTS-----------gpdhfedi.
G2MQR7_9ARCH/25-214                 ...................EQQESEDAARGRRA.EVLGGRQLDGFATVCEEILMEAGVPEKSIY..FDHE..AT..LPG.FFRATKRWDLAVIH..EGELLAAIEFKS-ITSSFG..NNLNNRTEEALGSPTDLYTAYEEGAYDPS.PRPWLGYLMLMSENGNSTGSVRV.S.E.PH.FDVLEEFDG...............ASYVDRGEQLCLRLLRQRLYDGCVFLLSDAEGGLDGEFWE.........
R6FJH8_9BACE/29-217                 ..................s-QLDRNNRDTGNRG.AVTGGKQMDGFVDLLAKVATDMGVPQNCIY..TKRN..Q-..LPG.YFRPTKDWDFLIVS.pTNKLIAAIEFKSQVG-SFG..NNFNNRTEEALGSAVDLWTAFRENVFPNQ.NAPWVGYLMAVERCKKSTSIIRV.T.E.PH.FKVLEEFKE...............TSYIDRYAILCRKLILERHYTATALLWTSDS---------stygdvas.
K5Z1E7_9PROT/29-220                 ...................KQIESGKADQGERA.GVTAGKNMDGFLALVLDIIKANGLAHAEFY..QNRA..ML.tLPG.YFRPTKLWDLLVIY..KNELIAAVELKSHVGPSFG..NNFNNRTEEAIGTAHDLWTAFREEAFGKQ.PRPFVGWLMMVEDAPESRRAVKD.S.S.PH.FPVFEEFKG...............ASYLKRYDLLCQRLVQEQLYTTAAVIAAERSAVNTGHFTE.........
A0A0A8ENH9_9ACTN/24-158             aagsdstmvratsvlrrwe--------------.---------HLAQAMVDALVERGVDRSWIQ..VGRD..AQ..LPSaYGLGSSPWDLVVRK..DGVPLAAARFT-QLGGQPGsmNNINNRIQDLTSAAYSV-RQHDDHD----.FQPYLGLFFILEEDERVNTPTR-.-.-.--.---------...............----------------------------------------rpgek....
D5MMJ7_9BACT/31-221                 ...................RQKQTGKADQGLRS.AVTGGAQMDGFIDLFTELITAAGIPARYIF..RSKD..VE..LPG.FFRPTKEWDLLVIR..EKTLLIAIEAKSQVGPSFG..NNFNNRTEEAMGSALDLWTAYREHAYLAS.PQPFLGYFFMLEDCDASNNPVKV.R.E.PH.FKVFPEFVG...............ASYCRRYELFCRKLVLERYYTTSAFITSTASDGSRGLFS-t........
A1WFA1_VEREI/29-125                 ...................KQKESGKADQGERA.AVTGGKNMHGVSRLVVDLVKANGLPNAQVH..QQRA..VL.tLPG.YFRPTKLWDLLVID..NGRLIAAVEFKSHVGPSFG..NDFNNRT----------------------.-----------------------.-.-.--.---------...............----------------------------------------gsp......
E0QQ27_9ACTO/23-205                 ...........qqqlsalg-----GRAQGGTRA.SVTGGKHLAGVNQLILEELERLGITGLKHY..TNRQ..AT..VPG.YYRASKSWDLLVLR..DDEPALALEYKSMTG-SEG..KNLNNRIDEVIGAAQDLHRAQQTGLLPKE.LK--RGYIFLMEVTPAVLNPVGT.S.T.KV.GTLDPIFES...............TCYLERMAIMCERLRNDGLYGMA-----------------walgvvrnp
B3EK31_CHLPB/24-214                 ................kqg--SSTGKKDAGNRS.AVTGGKHLDGFIKLLTELLAEAGLPDSAIH..VKST..T-..LPG.YFRPTKNWDLLVVV..DRILLASIELKAHIGPSFG..NNFNNRVEEALGNSTDLLTAYREGKFKPS.QKPWLGWLMLLEDAPKSTTPVRV.D.E.PH.FEVFPEFKE...............ASYAKRYGLFCERLMRERLYDGACLIMSDKAGGLKGKFTE.........
H6SPY2_RHOPH/37-226                 ...................RQQEGGSRDQGERA.GVTAGKNMDAFVDLVTDLVRANGLGDALVH..RQRA..LL.tLPG.HFRATKQWDVLIFQ..EKRLIAALEFKSQAGPSFS..SNFNNRCEEAIGTALDLWTACREGAFGPG.ARPFVGWLMLVEDAPGSRAPVRD.T.C.PH.FPLDPAFTG...............ASYLERYTVLCQRLMQERLYTAAGVMASPRDT--------dsyrdl...
F4KTK4_HALH1/27-214                 ...............qvtg----STKADQGNRS.AVTGGKQLDGFIELLVKVSEDLGVPKTCIY..TKGN..S-..LPG.YFRPTKDWDFLIIS.pKKQLIAVIEFKSQVG-SFG..NNFNNRTEEALGSAVDFWTAFREQGFIQT.QVPWVGYVILVEKADKSTFPVRL.Q.E.PY.FNIRPEFQA...............TSYLDRYALLCQKLMQERHYTATSLIWTNE----------hfeygaln.
A1BHP7_CHLPD/29-219                 ...................KQLLTGKADHGERA.GVTAGKNMDGFLALVLDIIQANGLAHAEIH..QNRS..ML.tLPG.YFRPTKLWDLLVIY..KGELIAAIELKSQVG-SFG..NNFNNRTEEAIGTAYDLWTAYREEAFGKQ.PRPFVGWLMMVEDAPKSRCAVRD.A.S.PH.FPVFGEFEG...............ASYLMRYDLLCQKLVKEQLYTTAALITSTRCAAETGEFSE.........
R6PPH5_9BACT/21-209                 ................knq---LAHSTDKSNRG.AVTGGKQLDGFIVILKKLALSAGVKRNCIF..TKNN..Y-..LPG.YFRSSKDWDFVILT.pSRKLLVAIELKSQIG-SYG..NNFNNRTEEALGSAVDFWTAFRKDQFPHQ.EAPWLGYLMIVGKDEKSTVSVKN.Y.E.NH.FPVREEFHG...............TSYLERYKILCQKLIQERHYTSTALLWTNDK---------edfgdveg.
D8P7K3_9BACT/24-227                 ...................KQVKSGKIDAGTRG.EVTGGTQMGGLEVLVSDILCEAGLKKVDVR..TRTA..LE..LPG.YFRATKKWDLIVVS..DGALVLAMEFKSQAGKSIG..NNVNNRSEEAVGSAKDIWTAFREGRFGTS.PAPFLGYLFLLEDRDNVKTPVAN.K.E.PY.FSVDPEFRGeshlkdtaahrryrgVSYSKRYELLCRRLVLERLYTSACFMMATNSRAT------kltq.....
K9VP54_9CYAN/30-224                 ..................a-QVLAGKVDQGNRS.AVTGGKQMDGFILTLTNFLLAAGVPQNHIH..VKKS..LT.vIPG.FFRPAKMYDFLVVNpeKRQLKVVIELKSQVG-SFG..NNFNNRTEEAMGAALDIWTAYREGVFGEApPPPWLGYLFVLEDSPASRTRVQV.A.E.PH.FAVLPEFRG...............ASYAKRYELFCQKMVRERHFTAACFLVTDREQVAQ-----tpnyte...
#=GC seq_cons                       .......................suptDtGpRu.uVTGGKphDGFhsLltclhhssGlscspIa..ppps..h...LPG.YFRPoKpWDLlVlt..cspLlAAlEhKSQlGsSFG..NNFNNRsEEAlGoAhDlaTAaREshFstp..tPalGahhllE-sspSpssV+s.p.p.Pa.Fsl..tFcu...............uSYhcRYplhCp+LltEphYsuushlhospst.................
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