GenomeNet

Database: Pfam
Entry: dTMP_synthase
LinkDB: dTMP_synthase
Original site: dTMP_synthase 
#=GF ID   dTMP_synthase
#=GF AC   PF02593.9
#=GF DE   Thymidylate synthase
#=GF PI   DUF166;
#=GF AU   Mian N, Bateman A, Eberhardt R
#=GF SE   COG1810
#=GF GA   24.40 24.40;
#=GF TC   25.20 24.40;
#=GF NC   22.00 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   10426953
#=GF RT   Identifying two ancient enzymes in Archaea using predicted
#=GF RT   secondary structure alignment.
#=GF RA   Xu H, Aurora R, Rose GD, White RH;
#=GF RL   Nat Struct Biol. 1999;6:750-754.
#=GF DR   INTERPRO; IPR003745;
#=GF CC   This family catalyses the synthesis of thymidine monophosphate
#=GF CC   (dTMP) from deoxyuridine monophosphate (dUMP). The physiological
#=GF CC   co-substrate has not yet been identified [1].
#=GF SQ   85
#=GS A6UNY9_METVS/4-214   AC A6UNY9.1
#=GS A4FY22_METM5/4-214   AC A4FY22.1
#=GS Q6LYL5_METMP/4-214   AC Q6LYL5.1
#=GS O28962_ARCFU/4-246   AC O28962.1
#=GS D3S3I3_FERPA/10-265  AC D3S3I3.1
#=GS D3RY84_FERPA/4-240   AC D3RY84.1
#=GS TMPS_METJA/20-260    AC Q58167.1
#=GS A6UVL3_META3/4-247   AC A6UVL3.1
#=GS A6UTI2_META3/14-224  AC A6UTI2.1
#=GS A8ZX04_DESOH/13-214  AC A8ZX04.1
#=GS D8GL31_CLOLD/22-266  AC D8GL31.1
#=GS G7WN88_METH6/4-256   AC G7WN88.1
#=GS F4BX40_METCG/4-256   AC F4BX40.1
#=GS D9PYL6_METTM/5-214   AC D9PYL6.1
#=GS G0H0D5_METMI/4-221   AC G0H0D5.1
#=GS F2KN02_ARCVS/4-206   AC F2KN02.1
#=GS Q12VG0_METBU/5-218   AC Q12VG0.1
#=GS Q6LYK5_METMP/4-221   AC Q6LYK5.1
#=GS A6VFR2_METM7/4-214   AC A6VFR2.1
#=GS F7XQQ5_METZD/4-247   AC F7XQQ5.1
#=GS B8FDB6_DESAA/5-207   AC B8FDB6.1
#=GS C6PYQ7_9CLOT/22-266  AC C6PYQ7.1
#=GS A0B973_METTP/4-255   AC A0B973.1
#=GS D5E825_METMS/4-245   AC D5E825.1
#=GS F0TBL0_METSL/19-237  AC F0TBL0.1
#=GS F6BDY8_METIK/4-220   AC F6BDY8.1
#=GS D5VT77_METIM/4-197   AC D5VT77.1
#=GS H1KWU8_9EURY/1-220   AC H1KWU8.1
#=GS D7E639_METEZ/4-248   AC D7E639.1
#=GS Q8TXX5_METKA/17-258  AC Q8TXX5.1
#=GS F0TAL0_METSL/5-219   AC F0TAL0.1
#=GS G7WNJ5_METH6/4-256   AC G7WNJ5.1
#=GS D5E8I0_METMS/5-218   AC D5E8I0.1
#=GS F8ALA3_METOI/5-228   AC F8ALA3.1
#=GS O28586_ARCFU/4-213   AC O28586.1
#=GS C9REK5_METVM/4-214   AC C9REK5.1
#=GS F4LVP2_TEPAE/23-267  AC F4LVP2.1
#=GS F6D740_METSW/6-224   AC F6D740.1
#=GS D3S5W1_METSF/5-228   AC D3S5W1.1
#=GS F4BT22_METCG/4-220   AC F4BT22.1
#=GS C7P9D4_METFA/5-228   AC C7P9D4.1
#=GS C7P866_METFA/9-224   AC C7P866.1
#=GS B1I1F1_DESAP/4-228   AC B1I1F1.1
#=GS H1KY51_9EURY/4-244   AC H1KY51.1
#=GS Q8TPT1_METAC/4-247   AC Q8TPT1.1
#=GS H1L1F9_9EURY/4-220   AC H1L1F9.1
#=GS C0GK51_9FIRM/4-239   AC C0GK51.1
#=GS Y575_METJA/5-228     AC Q57995.1
#=GS Q46AS4_METBF/4-247   AC Q46AS4.1
#=GS D1JI06_9ARCH/6-227   AC D1JI06.1
#=GS F8AN11_METOI/11-229  AC F8AN11.1
#=GS C7P8H5_METFA/4-244   AC C7P8H5.1
#=GS D9S2D9_THEOJ/42-268  AC D9S2D9.1
#=GS A0B6L7_METTP/4-220   AC A0B6L7.1
#=GS C9RDX0_METVM/5-228   AC C9RDX0.1
#=GS O26701_METTH/5-221   AC O26701.1
#=GS F6BEI8_METIK/4-244   AC F6BEI8.1
#=GS E3GZ61_METFV/4-218   AC E3GZ61.1
#=GS O27409_METTH/5-214   AC O27409.1
#=GS Q2FR90_METHJ/15-212  AC Q2FR90.1
#=GS F7XPC6_METZD/5-218   AC F7XPC6.1
#=GS Q647U6_9ARCH/9-169   AC Q647U6.1
#=GS D3S2K7_FERPA/4-212   AC D3S2K7.1
#=GS G0H0C5_METMI/4-214   AC G0H0C5.1
#=GS Q8Q098_METMA/4-247   AC Q8Q098.1
#=GS D9PWH8_METTM/4-220   AC D9PWH8.1
#=GS D3S5I4_METSF/4-244   AC D3S5I4.1
#=GS O28172_ARCFU/9-265   AC O28172.1
#=GS D3S586_METSF/4-218   AC D3S586.1
#=GS Q46DH7_METBF/5-218   AC Q46DH7.1
#=GS F8AL74_METOI/4-246   AC F8AL74.1
#=GS Q8PXV6_METMA/5-218   AC Q8PXV6.1
#=GS F6D5X9_METSW/4-213   AC F6D5X9.1
#=GS D5VU83_METIM/4-232   AC D5VU83.1
#=GS G7WP27_METH6/4-220   AC G7WP27.1
#=GS Q8TZ01_METKA/4-211   AC Q8TZ01.1
#=GS Q12VY8_METBU/4-247   AC Q12VY8.1
#=GS A6UNZ9_METVS/4-221   AC A6UNZ9.1
#=GS Y838_METJA/4-222     AC Q58248.1
#=GS A9AAX1_METM6/4-214   AC A9AAX1.1
#=GS D1JAT2_9ARCH/4-253   AC D1JAT2.1
#=GS C9RFG2_METVM/4-244   AC C9RFG2.1
#=GS Q8THT0_METAC/5-218   AC Q8THT0.1
#=GS D7E7H1_METEZ/5-218   AC D7E7H1.1
#=GS F0T7G5_METSL/5-213   AC F0T7G5.1
A6UNY9_METVS/4-214              ....................................k-IVSD..GPFGERAYETIKKKFECE--.......................YIILDTVKp..aSIDELAEI.P.KEQ.LEK......INNSDIVITYILNPDLTLDLVEQI.....F-.GKVKYI.IIGAWKGK...-----GLKNQLESFE-NVVCPE.IMCELEE...........NGNPIHDEFVSK..FGKPKLDIIVE.....ND..IV.....KKINVLRESPCGGTDFISKDLLGK.....NVKEIATLA........GLRIQH...YPCRAGRIRLFNEE..ESGRYKAATYHHDAFENAIKr........
A4FY22_METM5/4-214              .....................................VVVSD..GPFGERAYDTIKKEFECE--.......................YIILDIVKt..eSIDDFTEF.P.NEQ.ISK......IKSADILITYTLNPDITLDLIEQV.....H-.DNVGYV.IVGAWKGK...-----GLKNQLESFK-NVICPD.IMCELVE...........NGNKIFDEFVSK..FGKPKVEIKVE.....NN..IA.....TEIKVIRGSPCGGTNFVAKDLLGK.....NISDISTKA........GLRIQH...YPCRAGRIRLFSDE..ESGRYKAATFHHDAFEKALKk........
Q6LYL5_METMP/4-214              .....................................VVVSD..GPFGERAYDTIKKEFECE--.......................YIVLDIPKp..eSIDDFTEF.P.NEQ.LEK......IKSADILITYTLNPDITFDLVEQV.....Y-.DNVGYV.IVGAWKGK...-----GLKNQLESFK-NVICPD.IMCELVE...........NGNKIFDEFVSK..FGKPKVEIKVE.....NN..IA.....TKINVIRGSPCGGTDFVAKDLLGK.....NISDISTKA........GLRIQH...YPCRAGRIRLFSDE..ESGRYKAATFHHDAFEKALKk........
O28962_ARCFU/4-246              .....................................GIIYS..GEFGKRFVSNL-AYPYLCPTfgacgingcd..yckrydfsssiVYAKELAEp..qEIGLYVEE.P.ESY.LE-......PFECDIAVAINVHPDILVSLPEI-.....--.GEFKAL.IVPACNQNwclPGLRKQLAEKCGELGIEFASPK.PFCSLT-...........GNSGWISRFIDEfkIGRPEFRVERG.....GD..AI.....KKVEVIKSDPCGSAYFVAKRMTGY.....IIESKEDFW........KEIHQHqcaYPCMASMDRDVELK..EAPFHLAGYIMVYQFSTAAGv........
D3S3I3_FERPA/10-265             .....................................VVLYH..GNFGERFVANLMNYRNSCPSfgacgidscvqckdgvysfskniLATYAMIDp..tNLPDFIEN.A.EDF.LPK.....nFPEADLAVAINMHPDVLLALPEKL.....SE.FGIKAL.IVPIEEPRwatPGLVRQLKEKCEDLKLEFAAPK.PFCSLYE...........DEQPIIKRFFEEmaMGYPKFRIEVEe...eDGykKI.....EEVEVLRSHPCGCAWFVGIRLREF.....SFSTMRELWd.....rvSEAHHS...YPCTASMEKDVEYN..ETLLHVAGYITRHAVDKAIGy........
D3RY84_FERPA/4-240              .....................................GILYS..GEFGERFTSNL-AYPKSCPRfgacgidecdfcksydlskaivfVKQLNPPE....FYGDYIEE.P.ETI.VGE......IEDSDILIAINAHPDILAELPSV-.....--.AEFKCL.IVPVEDPKwlsPGLREQIRRVCEETGREFFSPK.PFCSSN-...........---TPLSKFG--..FGKPEFEVIMD.....GN..AI.....EEVRVLRSDPCGSAYYVAKRMRGY.....EIEKVEDFW........KEIHQHqcaYPCMASMDRDREIK..EAPFHLAGYVMVYQFSKACGi........
TMPS_METJA/20-260               ..................................vfi---YHknNQRMEKFYKNLLNEPDFCRIcddcyncr.......gnwtfknnVKNIVIEE....VYEEFVDN.P.YDY.LPE......LPEGDICIA-QLHEDLLYELPLLL.....KE.KGYKAL.IVPSETPHdlsLALRRDLKRVCSNYNIEFENPK.PFCSLEK..........kEGNEYINKFIDYfkIGKPELEIEVE.....NG..LI.....KDVKVKISAPCGETYYIAKRLKGK.....AIDDLKEEI........ANAHHN...YPCLASMEMDKELG..DTILHKAGYIAFEVVEKALKk........
A6UVL3_META3/4-247              ...................................tf--IYHkgNQRMEKFYKNLLNEPDFCRIcedcyncrg....dwsykddvkaVVLDAIDD....--DEFIED.A.SDY.IPE......LPEGDVAVA-QLHEDLLYELPNML.....AE.KNYKLL.IVPSETPSdlsIAMRNSLKEMCEKNGMDFENPK.PFCALKK..........rHNRKVLNEFINYfkIGFPQVEIKSS.....DG..HKi...dDDVKVIISAPCGETHYMSKRIKGK.....IINELKDKI........ANAHHN...YPCLGSMEYDKELE..DTMLHEAGYIALDAVKKAL-lp.......
A6UTI2_META3/14-224             .....................................LIISE..GKYGERAVKIIGDKFNCD--.......................FMKLNYLG....DFED-IEI.D.KNQ.LKE......IEKYDIVITYILNPDLTYYLLKEL.....S-.NKPLFT.IVGAWAGE...-----GFKKQLENFG-NVICPN.LMCDFNEedl....knklNKYPQLKEFLKY..FGAPKINLHIK.....DN..KI.....DGVEILRGAPCGSTNETMKEFIGK.....EYSEKTIID.......iGLRVQH...Y-CRAGKLRIFVEK..EGKKSKAGKCLVNGI-----nv.......
A8ZX04_DESOH/13-214             .....................................LVLQQ..RGRGETKTAGIKAYGQDRFH.......................IDLVSVEE....RLPAVIED.T.SAY.LPE......TIDADLVLDYLAHPDLSCDLADKC.....RD.RGIPVI.ASGKKYKN...---------------RWVYTPP.ICCALP-...........-RQADAGPYGQR..FGYPEFAVTLS....aDN..RI.....KDVRVVRGAPCGASWKAAEKMRGL.....PASDAVVRI........GLETQF...FCSADPAGWDPLWG..KSPVHLAADLHAHAFIKAVEe........
D8GL31_CLOLD/22-266             ................................ktdsr-----..-FAGAKFIPHIKNYKEACTVcgkkcvwcrg...kyelnfkesvSEVIELPD....IYELFEDN.P.LKY.LPQ.....kFKKHDAAVIIGVHEDIIIELPKII.....AE.SGGKAM.IVPCESGSwvsKWTREKLIEECEKYNLQYAFPK.PFCTLKY...........GKFPLINEFIDFfkIGKPKFRLYVN....dED..VI.....EKAEVIISAPCGNGYNIARHLLGK.....KLGEEAKKS.......vAKFWHS...YPCLGDMHVDPELG..DTPLHISGYTHYAALENA--qii......
G7WN88_METH6/4-256              .....................................VVLYN..GEFGRTLIGNLINFSGFCIScgdgctlck....agkyslaedlLSVIEMPDp..eGLEDFIDD.V.SPY.IPA.....eIPEADIAIVVHVHPDIIFGLLSIL.....KE.KGYKGI.IGGSEMPKdlpLGLRTQLAEEARRMGLEAAFAK.PFCALRP..........dPATPAINAFMQKahFGEPEIEIVAQesrpgKE..TI.....LAANVVRSAPCGSTWYVAKRMAGL.....ETDQPDLREr......iAEAHHA...YPCTASMEQDPELK..DTILHRAGYIIREAVEDAIKr........
F4BX40_METCG/4-256              ....................................a-VYYS..GDFGSRVVGNLVNFSGFCIScadactecr....nvapdlakdiVALVEMPDp..sTYGDFIDD.V.EPL.LPQ.....dIPKVDLVIVINVHPDILYGLLPKF.....KE.AGVKAI.IGGSESPKempLGQRRQVEEKAAELGMEAAFAK.PFCALAP..........dPNKPIIAQFLKEarIGNPVIEFTVQg..srEG..KEv...iMGANVVRSAPCGSTWFVAKKMLGL.....ETDQPDLREr......iSEAHHS...YPCTGSMERDAELG..DTVLHVGGYIIRDAVEGGLKk........
D9PYL6_METTM/5-214              ....................................a-IVTD..GPYGERTHENIGEEFETD--.......................FIELEAPSg..iFADE-VEI.P.EEK.IEQ......IVSADIVITYILHPDLTLELVDRI.....H-.NQVDWI.IVGAWRGE...-----GFRNQLLGYG-NVTAPE.NMCDLEE...........NGNPSFDEFVSK..FGKPVVEVDVE.....DD..RV.....KDIRVLRCSPCGATRFVAEELVGT.....EVKDLPVRA........GLKIQH...YPCRAAKMRLFADD..ECKKELAARIHCEAFERALEn........
G0H0D5_METMI/4-221              .....................................IVLYS..GNYGERVLNNILTKFAPN-I.......................ISVYEFEE....NLPEYIED.I.ENY.VPD.....nLPECDLLVVTGLHGDINLVTCKIA.....NK.TGAKSV.IIESHSQKqlpFGIRSEITESLLN--VKCVFPK.PFCSLKP...........VGDIYIDEFVKY..FGAPKIEI-IG.....EK..FI.....KSVIVHRNAPCGSTKYIAENLTGY.....PLNEAEIES........GNKLHN...YPCLASMEFDNEFS..DTILHLAGYKIKEAVKKSLGf........
F2KN02_ARCVS/4-206              ................................giiar-----..GRHGPLTARMMSE--YFE--.......................VSVFELPE....ELPVLIED.I.--E.LPE.....nILNSDIIISYAAHPDVNIRVVEG-.....--.AKARLV.ILTGKSGK...TGSRAQLKAIAEERGVRLLMVD.ICCVASE...........--IEGFEEFFNR..FGKPEFEVKIR.....NG..VL.....EDVKVTRCAFCGATCFVAERLKGA.....IIEDAPRLA........GYYTQI...YPCLASRG-----I..KGGIHLAAEMHKIAMERAIKa........
Q12VG0_METBU/5-218              ....................................g-VIVR..GKYGRRLIETVRFRSDLE--.......................VIVAEVPE....HLPELIDE.P.DEF.FSEldfngkVFDADIIITYSLHPDITPQIAKMA.....GE.AGVGAL.IVPGGAAK...-APIRELDDISLKYGIFIEVDD.ICCNIG-...........-SDPSIDAFTSF..FGNPVLDVGVK.....DG..KI.....SKVNVIRGAPCGSTWRMADALVGN.....AVEGAGAKA........GLLISQ...YPCRAVRG-----N..MGGIHESSELHKKAIDDAIKk........
Q6LYK5_METMP/4-221              ....................................t-VLYS..GNYGERVLNTILEKFAQN-I.......................VSIHEIPE....NLPEYIDD.V.SEY.VPE.....nLKESDLIISVGLFGDINLIVCDIA.....KK.TNAKSI.IIESHSPKqvtKGLKSEISDSLNE--IKIVFPK.PFCSLKP...........VGDTYIDEFAKY..FGSPEIEI-IG.....ET..IV.....KSVIVKRNAPCGSTKYVAENLTGY.....SLNEVEFES........GNKLHN...YPCLASMDVDNEIG..DTILHLAGYKIKEAVKKSLKf........
A6VFR2_METM7/4-214              ....................................f-IVSD..GPFGERAYDTIKKEFECE--.......................YIILDIPKp..eSIDDFTEF.P.KEQ.LEK......IKSADILITYTLNPDITLDLVEQV.....H-.DNVGYI.IVGAWKGK...-----GLKNQLESFK-NVICPD.IMCELEE...........NGNKVFDEFVLK..FGKPEVEIKVE.....ND..VA.....TEIKVIRGSPCGGTAFIAEDLIGK.....NISDISTNA........GLRIQH...YPCRAGRIRLFSDE..KSGRYKAATFHHDAFEKALKk........
F7XQQ5_METZD/4-247              ....................................c-ILYS..GEFGRKVIGNLVNLSGFCVScgdlcdqcr....rcrpsaadqiVGIYEITQ....NLPEFIEE.P.EEY.LPA.....mIPECDLLIAMDLHPDLLTGLPDIA.....EK.AGISGV.IVPVEQHRlgpPGIIEKVRKDLESKGIDCEFPR.AFCSLEK...........CGKPVIDRFVEM.gFGKPVLRVQLNe...rKD..HI.....VAADVITDAPCGSTCFVARKLRGT.....AVKEYKETV........SSAHHA...YPCTAGMEIDPQIG..DTILHRAGYIIRKSVEDALEd........
B8FDB6_DESAA/5-207              ....................................k-VFQQ..NNSGARKIAAVRERAGDDLV.......................LDVINIDD....ALPMVLDD.T.EEY.LKEa....wEMEADLVLDYLKHPDLSYDLCRIC.....SE.RGIPVV.-SPTKKWR...------------R--PHVFTPP.TCCGLP-...........-RNDELGAYACS..FGAPEVEAAVE.....DG..VV.....KEIRVIRGAPCGATWEAAQDVLGK.....PVEEAGVAI........GLKVQF...YCVADPAGWDPIYG..KSPVHFAGHVHQAALEKALRk........
C6PYQ7_9CLOT/22-266             ............................ktdsrfans-----..-----KFIPNLIDEKEVCTVcgkkcvwcre...kynlnfedsiSQIIKLPD....VYRMFEDE.P.LTY.LPD.....kFKDHDIAVIIGVHQDILAEIPNIL.....KK.SGGKGL.IVPCESGDwvsRWTREFVINQCEELGLEYAFPK.PFCTLNK...........GKFETINKFIDEfrLGKPKFKLHVN.....KD..NI....iVKAEVIISAPCGNGYNIAKHLVGK.....KLGEEAKKT.......vAKFWHS...YPCMGGMHVDPEIG..DTPLHIGGYAHYSALENA--eic......
A0B973_METTP/4-255              .....................................VVYYN..GEFGERVVGNLLNYPGFCIScgeactqcr....sgkysgaediVAAVEMPDp..sTLGDFIDD.V.EPL.LPA......VPEADIAIVINVHPDILFGMLPRM.....KD.AGIRGI.IGCSESPKdmpMGLRLQVSRAAEELGLEAAFSK.PFCAMRP..........dPLKPNIAAFLKRamIGEPELEIVLQ.....KG..REgkdviAAANVIRSAPCGSTWFVAKRLIGV.....EKDDPRLHEr......iSEAHHA...YPCTASMDRDPEIG..DTVLHRAGYIIRDKVEEAIRr........
D5E825_METMS/4-245              ....................................s-ILYS..GKFGERVLGNLINSDQFCTScgeacdhcr....qgrksysgflTEIHELPA....DLPEFVED.P.EEY.LPA.....dLKPCDLLLAMDLHPDLFTALPTVA.....KK.AHAKGV.IAPVENPKlapAGLIRQVAEKLQNEEVEYAFPK.PFCSLEK...........TGQPIIDRFVEM.gFGKPKIDIILD.....NG..EI.....TTARVLRDAPCGCTWFVARKLVYT.....EAADFKETV........SSAHHA...YPCTASMDNDTEIG..DTILHKAGYIVRESVGSALDk........
F0TBL0_METSL/19-237             ....................................y-IVSS..GEYGLRIINNIAKNGFAASI.......................VGMHEFPD....DLPEFIDN.P.EIY.IPG.....tIPESDLILALGLKGDINLTLPIIA.....SK.AGAKAV.ISEIHDPAqlpPGLQREVEESAGD--IKIVFAK.PFCSLKP...........VGDDVVDEFAHY..FGKPELKIE-S.....NK..LI.....KNVEVICGAPCGSTQFVADELEGF.....PVEDAELES........GNKIHN...YPCIASMATDPVVG..DTILHLAGYKIKEAVKVGVGf........
F6BDY8_METIK/4-220              ....................................g-ILSE..GKYGERAYNVIGKKFNCD--.......................FIKVKYSG....EFDD-IEI.D.KDV.LEK......LKDYDLFITYTTNPDLTYELVRQI.....SKiNKNAFV.IVGAWKGG...-----GFKKQLESFG-NAFCPD.LMCEIDEdvl....knyiDKFPQLKGFLKY..FGRPKVKIKCI.....DD..KI.....KDIEILREAPCGSTSETLKEFIGK.....EFNENTLKN.......iGLRVQH...F-CRASKIRLFVDN..ECKKIKAGEIIVQSVKEGINq........
D5VT77_METIM/4-197              ....................................a-IITD..GVYGENAYKTISKRFPTD--.......................LIRVSYSG....ELDD----.L.KVS.FDK......PLNHDLYILYIRDPDATLEVIKKI.....RE.KGEEPI.ILGISFGK...-----GLAKKFKN----VYAPE.LLCSDLP...........-----IEPFNKY..FGTPKVKLYIK.....NN..KI.....YKYEILKETPCGSVEKVLEEFKGK.....EFNDKTLKD.......mGLRIQH...F-CKAGKLRLFKEK..TCKKVKVGENLVKNI-----ev.......
H1KWU8_9EURY/1-220              ....................................m-IVSD..GAYGERAGNILKEHAKINEF.......................TGFFRIPKpsnfFVDE-IEL.P.KEI.VEK......FKEADILITYTTHPDNTYEVCRRC.....REeNPNIAI.IVAAWRGN...-----GQKKELQKF--DAICPH.IMCEIDEdn......lniEKYPKLKEFLKE..FGKPKVKVYVE.....GG..KV.....RDVEVLRTSICGSTIFMAENMVGM.....DVDDIGRKG........SMLIQR...YPCVAGKIHLFSDE..ECKKIKALTLHKEAIENGL-me.......
D7E639_METEZ/4-248              ....................................s-VLYT..GAFGEKVIGNLINNTNFCTScgellcdhcr...svrkgishliVQTYEFQE....DLPELIDD.P.AEY.IPE.....nLSETDLILAIDLHPDLLTVLPEIA.....RR.TKSSAV.ISPVERPQlapPGLVEQVKHELENAGVEAEFPK.PFCSLEK...........TGKKIIDQFVDL.gFGRPLLKIELN.....TD..NDt...fRFVRVLRDAPCGSTWFVAKQLTGT.....DVDNYKETV........SKAHHS...YPCTASMEKDVELG..DTILHQAGFIIRKSVEEGM-se.......
Q8TXX5_METKA/17-258             ...................................aa--LYS..HQFGKRMVANLLNEPGHCRAcgpvcdgck....ydmyslvdslVAVEELPKp..eELPPFVDE.P.EDH.LPE......LPPVDVLVAIGLHPDLLVALSEV-.....--.YEIKAL.IVPVEEPDwidPWIEEKLREVCEENSVELTVAR.PGCDLEP...........-SGPVTEAFCDAgmIGRPKLFMKVE.....DG..VV.....IDVHVVRSAPCGCTWFVAKRLVGV.....DADPEEVKAt......vSEAHHS...YPCTASMEVDKHVG..DTLLHVAGRLHIEAALRALEe........
F0TAL0_METSL/5-219              .....................................VVVTD..GPYGERAYENIKEKFDTE--.......................FVELEKPEs..mFMDE-IDI.P.LYE.LNK......IKEANILITYTQHPDLTLDIVDLV.....N-.KYVDHI.IVAAWSGE...-----GFKNQLESYE-NVTCPY.IMCELEE...........NGNEVFDSFTSK..IGKPKVDITLE.....NG..KI.....AIIDVIRSSPCGSTKFVSDYLSEKyfgsdDLENVPIEA........GLKLQH...YPCRAAKMRLFTDE..ECKKEMASGLHRDAFEEALNk........
G7WNJ5_METH6/4-256              ....................................a-VFYN..GEFGRTLIGNLINFSGFCIScgdgctlck....agkyslaedlVSVIEMPDp..eGLEDFIDD.V.SPY.IPA.....eIPEADIAIVVHVHPDIIFGLLSIL.....KE.KGYKGI.IGGSEMPKdlpLGLRTQLAEEARRMGLEAAFAK.PFCALRP..........dPATPAINAFMQKahFGEPEIEIVAQesrpgKE..TI.....LAANVVRSAPCGSTWYVAKRMTGL.....DTDQPDLREr......iSEAHHA...YPCTASMDQDPELK..DTILHRAGYIIREAVEDAIKr........
D5E8I0_METMS/5-218              .....................................GVITR..GKYGNRLIETLRQHSDFT--.......................VKTASLPA....RLPDFLDE.P.EEF.VKRldinpdVFNADTIITYSLHPDITPVIARMA.....GK.AGVSSL.IVPGGPSR...-ASPVEMDKISSEYGIYIEVDE.ICCTLPE...........--KEETAPYSSI..FGLPEIEVSTK.....NG..YI.....SDVRVLKGAPCGSTWKMAEKLIGT.....RIEDAPAKA........GLLIQQ...YPCRAVRG-----Q..LGGIHDSAELHKKAMEKALKs........
F8ALA3_METOI/5-228              .....................................LVITD..GAYGYRIQGTVNSFGKKNEFm....................giCKIDRP-Td..fIVDE-IEL.P.NEV.VDK......FKEADVLLLYTQHPDNTYEVCRTA.....KE.KNPNVViIVATWGGE...-----GQKKELSKF--DAICPD.EMCLLDEkda....gdliNKYPKLKEFLEE..FGTPKVEVYIK.....DN..KV.....EDVKVIRSSICGSTLFMAKSMKGL.....DARDIEDLSk.....ksAMMIQR...YPCVAGKIKIFR-K..ECKKQKALGIHKEAVLNGIKt........
O28586_ARCFU/4-213              ................................gvvtr-----..--KGKRQDDIRMFSQFFE--.......................VKVYEIPE....ELPELIDE.P.AEI.LRLp....dDFDVDMIVSFAAHPDINLELIKQA.....AE.RGIGLV.IISGGAKG...-GAYKQLKEEGEKRGVRVVWEE.ICCATPK...........VEDERTREFFEH..FGAPEVEVEVE.....NG..KV.....KDVRVKRSAFCGATYYVAEKIKGL.....SVEEAPTKA........GYYTQI...YPCLAPRG-----H..EGGIHKAARAHKRAVEKAIEk........
C9REK5_METVM/4-214              ....................................a-ILTD..GAYGDRAHETIKKKFPCD--.......................IIKVKYYG....DFDE-IVI.D.KEI.LNK......LNDYDLFITYTLNPDLTYEIVKSI.....N-.-RKSFV.LVGAWKGE...-----GFKKQLESFG-NVFCPN.LMCEIDEekl....dkyvNKYPQLKEFLEY..FGRPKINVILD.....NN..KI....iRKIEILREAPCGSTSKTLEEFIGK.....KFDDNLLLN.......iGLRVQH...F-CRAGKIRIFVEK..EGKKTKAGKLLVEGI-----tp.......
F4LVP2_TEPAE/23-267             .....................vkyggefaarkflphl-----..--------TNFKNNPDFCTKqcyqfrqr......faldftediAKIMLFPS....VLPELIDD.A.QSY.LKD.....aIPAHDILVAVGVHPDILIELIRKA.....IS.AGCKAV.VIPREDPDwltTSFVNKLKNMCETKGLEYAFPR.PFCSLSK...........GKFIYINAFIDQfkIGKPKYEVITD....eKE..NV.....IDVDVKCSSPCGATYHVASGLIGI.....NRENMVDAA........NRLWHV...YPCLSSSHMDPEIA..DSPMHLAAYINLYAAKDAQ-kn.......
F6D740_METSW/6-224              ....................................f-ILSC..GEYGSRIINNIANKGLGSSI.......................IGLHEFPD....DLPEFIDD.F.EEY.IPK.....eLPECDLILSLDLYGDINMVIPAIA.....RK.TGAKSI.IVPIHDPAqipPGLQREIEEAAGD--VTIVFPK.PFCSLKP...........TGDEVIDEFVKY..FGKPEVEI-DS.....DE..RI.....KSVKILRDAPCGAAGYVAENLEGL.....NVEDAEMEA........GNKIHN...YPCLASMKTDPMIG..DTILHLAGYKIKEAVKESLGf........
D3S5W1_METSF/5-228              .....................................LVVTD..GAYGYRIKGTVNSFGKKNRFi.....................gIYKIDRPDd..lIVDD-IEF.P.EEL.LKK......IKEADILLLYTQHPDNTYYLCYEA.....RKlNKDIAI.IVATWSGE...-----GEKKELKKF--DAICPE.EMCLLDEnev....gnliNKYPKLKEFLEE..FGTPKVKVYVK.....DN..KV.....VDVEVLRTSICGSTLFMAKLMKGM.....EVNDIEDFAk.....ksAMLIQR...YPCVAGKIKLFR-G..DCKKQKALNIHKDAILEGITf........
F4BT22_METCG/4-220              ....................................g-VIKR..GKYGERLLETIKDHTDFE--.......................VVSVDVPE....ILPGFIED.P.EEF.VRElnldpqIFQADLLILYTFHPDLTPEIVRLA.....GK.EGVKAV.IIPGGIGR...AGSITELEKIAEVHNIHIEVDE.ICCTLEE...........CGVPAIDQFAKK..LGKPELEVQTK.....DG..KI.....SGVRVLRGSPCGATWHAATDIVGK.....TVAEAPSLT........GLFCQQ...YPCRAVRG-----G..PGGIHTSGDLHKDAMERALGk........
C7P9D4_METFA/5-228              .....................................LVVTD..GAYGYRIRGTVDSFGKKNEFi.....................gI--YKIEKpndlVVDD-IEF.P.EEL.LEK......IKEADILLLYTQHPDNTYYLCYEA.....RIlNEDIAI.IVATWKGE...-----GEKKELRKF--DAICPE.EMCLLDEnev....gdliNKYPKLKEFLEE..FGAPKVKVYVK.....DN..KV.....VDVEVLRTSICGSTLFMAKLMKGM.....EVNDLEEFGk.....ksAMLIQR...YPCVAGKIKIFR-G..DCKKQKALNIHKEAVLKGITy........
C7P866_METFA/9-224              ....................................a-ILSD..GAYGERAYKTIKSKFPCE--.......................FIVVKYHG....DFDE-ITI.S.EEI.LKN......LKNYNLFLCYTLNPDLTYELVKKI.....KElNSKAFI.LIGAWKGE...-----GFKKQLESFG-NAFCPH.IMCDIDEnel....kdylNKYPQLKKFLKY..FGKPKVKLYIK.....NK..KI.....KNIEVFREAPCGSTSETLKEFIGK.....EFNDKTLTD.......iGLRVQH...F-CRAGKIRIFVEK..EGKKTKAGRILVNGI-----qivne....
B1I1F1_DESAP/4-228              ....................................l-LIIQ..GDYGRRYVEAMTQYAPFGWE.......................VNHYVFPE....KLSIGIDD.SlEDF.LPP.....sLPGGDLLLMLQEDPVVA-EMAPYL.....AEmAGVKAV.LAPIENKAylpSGLAKQIKKKLAERDIAMVHPL.VFCALAEe.........dSANPYIQAFARH..FGRPKVEIALD.....KD..KI.....AEVKVLRDAPCGNTRYVAKNLVGV.....HVKDAVEQA........GLLHHA...YPCVATMTHDQEIG..DTLMHQAGLMTKTAVEEALKe........
H1KY51_9EURY/4-244              ...................................vf--IYHegNNRMEKFYKNLLNESDFCKIcedcyncr.......gdwsfkddVKNVVVKE....AKEEFIDD.P.YEY.LPE......LPEGDVCIA-QLHEDLLYELPLLL.....KE.KNYKGL.IVPSETPHdlsPALRRDLKRICKEYNIEFENPK.PFCSLEK..........kEGNETINKFIDYfrIGKPELEIEVE.....GH..TI.....KDVKVKISAPCGETYYIAKRIKNK.....EIKGLKEEI........ANAHHN...YPCLGSMEYDKELE..DTILHEAGYIAIESIKKALNk........
Q8TPT1_METAC/4-247              .....................................LVLYT..GELGKKVIQNLINPSTFCVScgelcnhcr....qvrksyanllVGIHEFPE....DLPPFIEE.P.AQF.MPP.....kLPECDLILAIGIHPDLLIALPEVV.....EK.TGAKAV.IAPAEDSKktpAGVLEQLRKELEAMGVEFEAPK.PFCALEK...........TGKPVIDAFVDL.gFGKPMLRIEMS.....PD..GKm...fIGAGVLRDAPCGSTWFVAKKLGWT.....DASGYKETI........SGAHHS...YPCTGSMDKDPQIG..DTILHKAGYIIREAVEEGMEc........
H1L1F9_9EURY/4-220              ....................................g-ILSE..GKYGERVHKVIGKKFNCD--.......................FIKVKYSG....EFDD-IKI.D.KDI.LEK......LEDYDLFITYTTNPDLTYELVRQI.....RKiNKNAFV.IVGAWKGG...-----GFKKQLEGFG-NVFCPN.LMCEIDEsvl....knylDEFPQLNKFLRY..FGRPKVKIILE.....NN..KI.....KDIEILREAPCGSTSETLKEFIGK.....EINEKTLKN.......iGLRVQH...F-CRASKIRLFVDN..ECKKIKAGEIIVQSVKEGL-ik.......
C0GK51_9FIRM/4-239              .....................................LILQQ..GIYGERITENIKNKAPEGWS.......................ISTFNVPA....IQEPIVDE.P.EEY.LPK.....nLPSADLILHLAESAQAAQLLPAVA.....KA.TGADAV.IASIDTTAwvpMGLRNQLHRELAKMDVTIVFPE.PLCSIDEetvgfneslqpYTSETIREFSRY..FGKPILEVKVD....sEG..KI.....SEIEVLRGSPCGSTEYTIKRVKGM.....PAEKAVPTS........GLMCLH...YPCLASMTFEQKANgvDTIMHNSGRIFNEGMENALKk........
Y575_METJA/5-228                .....................................LVVTD..GAYGYRIKGTINSFGKKNKFi.....................gIYKINKPDd..lIVDD-IEF.P.DEL.LEK......IKEADILLLYTQHPDNTYYLCYEA.....RRlNKDIAI.IVATWSGE...-----GEKKELKKF--DAICPE.EMCLLDEnev....gsliDKYPKLKEFLEE..FGTPKVKVYVK.....DN..KV.....IDVEVLRTSICGSTLFMAKLMKGM.....EVNDIEEFAk.....ksAMLIQR...YPCVAGKIKIFR-G..DCRKQKALNIHKEAVLEGI-if.......
Q46AS4_METBF/4-247              .....................................LILYS..GELGTKVIQNLINSGNFCVScgelcnhcr....qvrksyanliVGIHEFPQ....DLPTFIEE.P.EQY.MPQ.....kLPECDLILAIGIHPDLLTALPDVV.....TK.TKAKAV.IAPVEDSKktpAGVLEQIKKDLEAIGVEFEGPK.PFCALEK...........TGKPVIDAFVDL.gFGKPVLRIEMS.....PD..GKm...fIGAGVLRDAPCGSTWFVAKKLGWT.....DTVEYKETI........SGAHHS...YPCTASMDKDPQLG..DTILHKAGYIIREAVEEGMEc........
D1JI06_9ARCH/6-227              ....................................y-ILYH..GSFGELVTGHLAMSGLADRI.......................VGLYDLKV....ASVS-FDD.P.END.MPEd...ipLSACDLLLVLGILPKAGDLVPIIA.....KR.TGAKAV.IWPIEDPNl.iPEGRYSIEDELKKDGIHVEFPE.PLCTLDT...........SENEIVNSFAEH..FGMPKFELRVN....aKN..MI....iEEVKVIRDTPCGTASKIGPKIVGM.....SYKDMKSLEd......kVMQMHD...NECVAYMGP----D..RPIMQQAGRLLADAIKE---elpy.....
F8AN11_METOI/11-229             ....................................a-IVSE..GKYGDRATKVIGEKFNCN--.......................FLKINYTG....DFED-IEI.D.RAQ.LDE......MKKYDIIITYTINPDLTYTLINEIsninkKE.KKNIFV.IVGAWKGE...-----GFKKQLESFG-NVICPD.LMCNLDEhil....kdkiEKYPQLREFLKY..FGKPIVEVYLD.....DN..DI....iKYIDVIREAPCGSSSDTLKEYIGK.....KYDKKTLIN.......iGLRVQH...F-CRAGKLRVFTEK..ESKKSRAGRILVEGI-----nlk......
C7P8H5_METFA/4-244              ...................................if--IYHrgNERMEKFYKHLLNEPDFCRIcedcyncr.......gnwsfkdnVKNIVINE....VYEEFIDN.P.YDY.LPE......LPEGDVCIA-QLHEDLLYELPLLL.....KE.KNYKAL.IVPSETPHdlsPALRRDLKKVCERYNIEFENPK.PFCSLEK..........kEGNEFINKFIDYfkIGKPELEVEVE.....NN..II.....KDVKVKISSPCGETYYIAKRLKGK.....SLDNLKEEI........ANAHHN...YPCLGSMEMDKELK..DTILHKAGYIAIESVEKAIRf........
D9S2D9_THEOJ/42-268             .........yksgkgivdkrcleyrrrfdldnskyia-----..--------------------.......................-GLIVFPG....IMPQIVDE.P.GEY.IPP.....eIPEHNILIAAGVHPDLMIELIKKA.....AD.SGCRAL.IAPREHPSwidSVLEKEIRALCAGLGIECVFPR.PFCALQK...........SGLAFIDEFLEAfgIGKPEYEIILN.....KN..GI....iQDVSVRYSSPCGATYYVAAGLIGM.....KKQEAVETA........NKLWHC...HACLASSIIDPDLG..DSIMHIAARINLVVAKRAVEn........
A0B6L7_METTP/4-220              .....................................GVITR..GKYGERLIDTILRHTDFD--.......................VVHAAVPE....TLPGFIED.P.DEF.LRSidlnedVFSSDLIVMYTLHPDLTPAIARIA.....GE.RGVKAL.LIPGGIGR...AGSIEELRSISERYNVYIEVDE.ICCTLEK...........VGVDAVDQFAEH..LGRPELRVELN.....SG..RI.....GRVDVVRGSPCGSTWHVARELIGK.....SVAEAPSLA........GLACQQ...YPCRAVRG-----T..PGGIHTSGDLHKNAMERALGm........
C9RDX0_METVM/5-228              .....................................LVVSD..GAYGYRVQGTVNSFGKKNKFl.....................gIYKIDRPDd..lLVDN-IEF.P.EEL.LEK......IKEADILLLYTQHPDNTYYLCYEA.....RRlNKDIAI.IVATWSGE...-----GAKKELSKF--DAICPE.EMCLLDEeev....rgiiDKYPKLKEFLEE..FGTPKVRVYVK.....NG..EV.....KDVDVLRTSICGSTLFMAKLMRGM.....KVNDLEEFAr.....nsAMLIQR...YPCVAGKIKIFR-G..DCKKQKALNIHKKAILDGL-ti.......
O26701_METTH/5-221              ....................................i-MVTA..GNYGARVVNTMAVHGLAPQI.......................VAVFDYTG....EGGDFLDD.P.SSL.LPA.....rTPDADLTVAAGLGGDLNLVAAEIA.....AE.SGSGGI.IVESHAPG...-QLPDGLRSEIDSLVDCAIFPT.PFCSLEP...........VGNPHIDAFASR..FGKPEVEME-G.....NE..RV.....VSVKVKRSAPCGSTFYVAENIRGV.....PLDEVDVAA........GEKFHN...YPCLASMEVDPRFG..DTHLHVAGYLTREAFKRAAGv........
F6BEI8_METIK/4-244              ...................................vf--IYHegNNRMEKFYKNLLNEPDFCKIcedcyncr.......gdwsfkddVKNVVIKE....TKEEFIDD.P.YEY.LPE......LPEGDVCIA-QLHEDLLYELPLLL.....KE.KNYKAL.IVPSETPHdlsPALRRDLKRMCKDYNIEFENPK.PFCSLEK..........kERNETINKFIDYfrIGKPELEIEVE.....RH..TI.....KDVKVKISAPCGETYYIAKRIKNK.....EIKGLKEEI........ANAHHN...YPCLGSMEYDKELG..DTILHEAGYIAIESIEKALNk........
E3GZ61_METFV/4-218              ....................................a-VVTD..GRYGERSYKTIKKYFDCK--.......................IVKMKCPSe..aFLDD-VEI.P.NNV.FKK......LKDTEIILIYILHPDVIYELVRRI.....S-.DGKKWI.IVASWDGK...-----GFKKQLQAFK-NVICPD.LMCNIRK...........IGDKTFDKFASK..IGKPKVEIKIK.....NG..KL.....KDIKVLRTSPCGATLFVANYIKKK.....YINKKITKDlp...reaGFKVQH...YPCMAPKINILVDN..ECKKQFASELHKEAFEKALKn........
O27409_METTH/5-214              ....................................a-IVTD..GPYGERAYENIAREFETM--.......................FIELEAPSg..iFADE-VDI.P.ADK.LKA......IRSADIVITYILHPDLTLELVDEI.....H-.GDVDWI.IIGAWRGD...-----GFRNQLLSYG-NLTAPE.NMCDLEE...........NGNPSFDEFVSR..FGRPLVEVDLE.....GD..TV.....KEIRVLRSSPCGATLFVAEELTGE.....DAQDLPLKA........GLKIQH...YPCRAPKMRLFSDD..ECKKEMAARMHSEAFERAIGv........
Q2FR90_METHJ/15-212             ....................................g-IVSD..GQYGERAFEQIRRRFPTE--.......................WILLPYPSs..pVVDE-IEL.T.---.---......IPPCDLYISYLRHPDIAMELIR--.....--.TGIPAL.LGINLGPG...------FIAQAHEFNPAVIGPE.TMCSVLP..........nTKFCQVNEYAKV..FGRPVFYLVMD.....GD..RI.....VWCKTIRGSPCGSTDAAASEISGQ.....ILDQEALSR........FALSIC...HNCRAPRFG----K..TCDKEKAGIIHLEELMRALKg........
F7XPC6_METZD/5-218              .....................................GIITR..GKYGKRLVKTLRSKTDLK--.......................SIVAQLPE....NAPQLIDE.P.LQF.LEKagfdyeVFDADIIITYSLHPDLTSAIANLA.....AK.NGVKAL.IIPGGRSQ...-APVQELQKISRESGIYIENDE.ICCTLKE...........--NAFTSDFTSK..LGTPELKISIC.....ED..KV.....SRVQVIRGAPCGSTWYMADKLKGV.....NVKEAPSMA........GLLVQQ...YPCRAVRG-----T..HGGIHESAEVHKRAVEMAL-ld.......
Q647U6_9ARCH/9-169              ...............................pkagdl-----..--------------------.......................--------....--------.-.---.---......--------------------VPII.....AErTGAKAV.LWPIEDPNl.iPEGKYSIAEELKNKGVHIEFPE.PLCSLDTd.........tSDNEQVKSFVAS..FGKPKFELRVN.....AK..QKv...iETIKVTRDTPCGTASKIAPKLVGM.....SYEDMKSFEd......aVAQMHD...NECVAYMG----PE..RPIMQQAGRLLVDAIKGAISk........
D3S2K7_FERPA/4-212              ....................................g-VVLR..GKYGRRAAKEISEF--FE--.......................VYTYELPQ....NLPEIIDE.P.EELnFPD.....eLFECDIIVSYALHPDVNYEIIRRA.....A-.GKVKYV.LLPGGAKS...-GSKKQLEELGKKYGVNVLVEN.ICCATPK...........IDDPEVKEFFEK..FGMPEFEIEVE.....NG..VI.....KSVKVKRSSICGSSKFVAEKLVGM.....RVDEAPAKA........GYFTQI...YPCFASRG-----I..DGKIHRAAHIHKRQVEKALRg........
G0H0C5_METMI/4-214              .....................................VVVSD..GPFGERAYDTIKKEFECE--.......................YIVLDIPKp..eSIDDFTEF.P.NEQ.LEK......IKSTDILITYTLNPDITFDLVEQV.....Y-.DNVGYV.IVGAWKGK...-----GLKNQLESFK-NVICPD.IMCELVE...........NGNKIFDEFVSK..FGKPKVEIKVE.....NN..IA.....TKINVIRGSPCGGTNFVAKDLLGK.....NISDIAVKA........GLRIQH...YPCRAGRIRLFSDE..ESGRYKAATFHHDAFEKALKk........
Q8Q098_METMA/4-247              .....................................LVLYS..GELGKKVIQNLVNSSSFCVScgelcnhcr....qarksyanliVGIHEFAD....DLPAFIEE.P.AQY.MPP.....nLPECDLILAIGIHPDLFAAIPEVV.....QK.TGAKAV.IAPSEDSKktpAGVLEQLRKELEAMGIEFEAPK.PFCALDK...........TGKPVIDSFVDL.gFGRPVLRIEMS.....PD..GKm...fIGAGVLRDAPCGSTWFVAKKLGWT.....DVSGYKETI........SGAHHS...YPCTASMDKDPQIG..DTILHKAGYIIREAVEEGMEc........
D9PWH8_METTM/4-220              ....................................i-MVAC..GEYGARVVNTVASHGLAPDI.......................VAVFDYDD....YSGEFLDD.P.SSL.LPP.....eIPDADLTVAAGLFGDLNLVAAEIA.....VE.SGSKAI.IVESHAPG...-QLPEGLKSEISGMVESAVFPS.PFCSLDT...........TGNPFIDSFASG..FGKPEVEMDVK.....E-..SV.....LAVRVKRSAPCGSTFYVAERIRGV.....PLHEVDVAA........GEGFHN...YPCLASMEADPALG..DTHLHVAGYLTREAFKRAAGv........
D3S5I4_METSF/4-244              ..................................vfi---YHknNQRMEKFYKNLLNEPDFCRIcddcyncr.......gnwsfkdsVKNIVIDE....VYEEFVDN.P.YDY.LPE......LPEADVCVA-QLHEDLLYELPLLL.....KE.KGYKAL.IVPSETPHdlsLALRRDLKRVCSEYNIEFENPK.PFCSLER..........rEGNEYINKFIDYfkIGKPELEIEVE.....NG..II.....KDVKVKISAPCGETYYIAKRLKGK.....AIDDLKEEI........ANAHHN...YPCLASMEIDKELG..DTILHKAGYIAIKAVENALKr........
O28172_ARCFU/9-265              .....................................IVFQH..GFFGERFVANLMNYPNSCPSygacgidgctqckeglynfskniIAVFSMPDp..tTMPDFIEN.A.EDF.LPK.....vIPEADIAVAINLHPDVLAVMPEKL.....K-.GKVKAL.IVPVEEPRwcsPGLAKQIREKCDELGLEFAAPK.PFCNLRP..........sEEHPTINRMIEEmrIGYPEFEIELL.....ED..GK.....AYVRISRSQPCGCAYYIGVKLRGF.....DFSEVKEGKmrelwnvvAEAHHS...YPCTASMERDNEYN..ETLLHVGGYIARHAVNRALGy........
D3S586_METSF/4-218              ....................................a-ILTD..GAYGDRAYKTIKSKFPCD--.......................FIIVKYYG....DFDE-ITI.S.KDT.TEK......LKDYDLFITYTLNPDLTYELIRNI.....KElNDKAFV.LVGAWKGE...-----GFKKQLESFG-NAFCPY.LMCDIDEdel....kyylNNYPQLREFLKY..FGRPKVKLFIK.....NN..KI.....EKIDVLREAPCGSTSETLKEFIGR.....EFDDKVLID.......iGLRVQH...F-CRAGKIRLFVEK..EGKKTKAGKILVKGIE----vih......
Q46DH7_METBF/5-218              .....................................GVITR..GKYGHRLIETVRENSDFS--.......................VVTADLPE....FVPVFIEE.P.DEY.LDAlnfdrhVFSAEIIITYSLHPDLTSAIAKLA.....AE.AGVRSL.IVPGGPSR...-ASVPELKKISEVSGMDIEVDE.ICCSLEP...........--NDFNRPFAEL..FGSPILKIKTK.....DG..KI.....ADVKVIKGAPCGSTWYMAKEIVGM.....DVKDAPPKA........GLLIQH...YPCRATRG-----E..IGGIHESGELHKQAFIKALEn........
F8AL74_METOI/4-246              ...................................tf--IYHkgNQRMEKFYKNLLNEPDFCRIcedcyncrg....dwsykddvkeVVLEPIDE....--DEFIED.A.SDY.MPE......IPQGDVAIA-QLHEDLLYELPNML.....AE.KNYKLL.IVPSETPSdlsIAMRNSLKEICEKNGIDFENPK.PFCALKK..........kYNKDVLNEFIDYfkIGFPQLEIKSS.....DG..HK....iDDVKVIISAPCGETYYIAKRIKGK.....IINELKDEI........ANAHHN...YPCLGSMEYDKELE..DTMLHEAGYIALDAIRKAL-lp.......
Q8PXV6_METMA/5-218              .....................................GVITR..GKYGHRLIETIKEHSDFS--.......................VVTADLPE....FVPAFIEE.P.DEF.LENlnfdrnVFSAEIVISYSLHPDLTQAIAKLA.....AE.AGVRSL.IVPGGPSR...-ASVPELKKISEISGMDIEVDE.ICCTLEP...........--NLYNKPFAEI..FGSPVLEVRTE.....NG..KI.....AEVKVLKGAPCGSTWHMAKEIVGV.....PVKDAPPKA........GLLIQH...YPCRAARG-----D..LGGIHESGELHKQALIKALEn........
F6D5X9_METSW/4-213              .....................................VIVTD..GTYGERAHETISKEFESE--.......................YIAMEPPSs..mFMDN-VEI.P.EET.LKQ......LESADILVTYVLHPDLTLELVERL.....H-.DKVGWI.IVGAWRGE...-----GFKNQVESFG-NVTCPE.NMCDLEE...........NGNPIFDEFVSN..FGKPVVEIECK.....DG..KV.....TDVQVLRTSPCGSTFFVADEMIGK.....NLEGLPVLA........GLRIQH...YPCRAPKMRLFTDD..ECKKEMAANFHKDAFEEAIKr........
D5VU83_METIM/4-232              ...................................lf--IYHegNKIMEKFYNNLINAPDFCKIcedcyncr.......gdwsyknyVDKMIIKK....ADEEFIDE.P.EEY.FED......VPKAEYYIA-QLHEDLLYHLAHLI.....E-.--GKAL.IVPSESPHdlsLGMRRELEKICKERGIIFKNPK.PFCSLEG...........-----LDEFTNFfkIGKPKVEVIVE.....ND..II.....RNVKVLVSSPCGETYYIAKRLKGK.....KLDEMDKEI........ADAHHN...YPCLASMELDKELG..DTILHKAGYIAREAFK----lg.......
G7WP27_METH6/4-220              ....................................g-VVIR..GKYGERLIETIRERTDFE--.......................VVSVEIPQ....ALPEFIED.P.EEF.LDGldldpeFFSSELIITYSLHPDVTPEIAVRA.....GK.GGAQAV.IVPGGIGR...AGSVPELQKIADRYGIYIEVDE.ICCTLDP...........CGVEAVDAFAEK..LGRPRLEVEVE.....DG..RI.....ARAEVLRGSPCGSTWHVARDIVGV.....TVEDAPPRA........GLLCQM...YPCRAVRG-----G..EGGIHTSGDLHKAAMEEALGi........
Q8TZ01_METKA/4-211              ................................lflgy-----..-RYGSRAAENVGSRSDFDVE......................fLKVKEPPEn..vILDE--EY.A.RTL.LPP.....sYSGFDLVISYLQHPDLQLALAEVC.....D-.SPILYG.ITPDP---...-----AVREKIERSHDAVAFPEtTMCSLLP..........dTGIPEVDRFAER..FGRPKLEVSVS.....GG..KI.....RTVRVVRGAPCGATWVAAERVEGM.....SVDEEAVNA........FALAAC...HHCVAPRFGKFESK..D----VTAYLHGVALAEALGi........
Q12VY8_METBU/4-247              ....................................s-FYYN..GEFGKKVIGNIVNSSTFCTScgdlcdhcr....elkishadsiVDLYEFPD....DLPEFIDD.P.FDH.IPK.....nVGECDLLIAMDLHPDIFSVLPEIA.....AN.AKAKAV.IAPVEVPKlapAGLVQQVKGKLESAGIDCEFPK.PFCSLTK...........TGKALIDEFVDM.gFGRPLLRIEID.....SD..RRi...fSHVQVLRDAPCGSTWYVAKKLRWT.....DIEDYKEIV........SGAHHA...YPCTASMDKDTQLK..DTILHEAGYIIRGSVEEASGf........
A6UNZ9_METVS/4-221              .....................................IVLYS..GNYGERVLNNILTKFAPN-I.......................ISVYEFEE....NLPEYIED.I.ENY.VPD.....nLPECDLLVVTGLHGDINLVTCKIA.....NK.TGAKSV.IIESHSQKqlpFGIRSEITESLLN--VKCVFPK.PFCSLKP...........VGDIYIDEFVKY..FGAPKIEI-IG.....EK..FI.....KSVIVHRNAPCGSTKYIAENLTGY.....PLNEAEIES........GNKLHN...YPCLASMEFDNEFS..DTILHLAGYKIKEAVKKSLGf........
Y838_METJA/4-222                ....................................a-ILTD..GVYGDRAYNTIKSKFPCD--.......................FITVKYYG....DFDE-ITI.S.ENT.IEK......LKDYDLFITYTLNPDLTYELVRKI.....KElNNKAFV.LVGAWKGE...-----GFKKQIESFG-NAFCPY.LMCDIDEdelkd.ykdylDNYPHLKEFLKY..FGKPKVKLYIK.....NN..KI.....EKIDVLREAPCGSTSETLKEFVGR.....EFNDKTLID.......iGLRVQH...F-CRAGKIRLFVEK..EGKKTKAGKILVSGI-----qviqi....
A9AAX1_METM6/4-214              .....................................VIVSD..GPFGERAYDTIKKEFECE--.......................YIILDITKt..eSIDDFTEF.P.KEQ.LAK......IKSADILITYTLNPDITLDLIEQV.....H-.DNVGYI.IVGAWKGK...-----GLKNQLESFK-NVICPD.IMCELVE...........NGNKVFDEFVSK..FGKPEVEIKVE.....NN..IA.....TEIKVIRGSPCGGTNFVAKDLLGK.....NILDIATKA........GLRIQH...YPCRAGRIRLFSDE..ESGRYKAATFHHDAFEKALKk........
D1JAT2_9ARCH/4-253              .....................................IVIYS..GDFGERVIGNLINYSAFCIScadacthckda.kygfadsikgfFKLIDTA-....LLPVFIEDsA.DEY.LPD.....dIPNADIAIVSEIHNDLLLELLPIL.....KD.SGIKAV.IVPQESAA...MIARPQIEEICDREGIEIVFPK.PFCDLHLk........qeDDKPVIRRFVTEfgIGRPEVRVEVD....rRG..RI.....AHVEVLRSAPCGSTWFVAKQLEGV.....EVENKRELYd.....riSESHHS...YPCTASMERDRELG..DTVLHKAGYLIREAIEAAV-dl.......
C9RFG2_METVM/4-244              .................................vfiy----HkdNQRMEKFYKHLINEPSFCRIcedcnncr.......gnwsfkdkVKNIVIDN....VYEEFVDD.P.YQY.LPD......LPEGDVCIA-QLHEDLLYELPLIL.....KE.KNYKAL.IVPSETPHdlsLALRRDLNKFCEKFNIEFENPK.PFCSLEK..........kDEKPFIKQFIEYfkIGKPELEVIVR.....DN..KV.....EDVKVKISSPCGETFYIAKRLIGK.....NLKDIKEEI........ANAHHN...YPCLASMEMDKELG..DTILHKAGYIAIKSVEDGIKk........
Q8THT0_METAC/5-218              .....................................GVITR..GKYGHRLIDTIKEHSDFL--.......................VVSADLPE....LVPVFIEE.P.DEF.LDSmnfdlsVFSAEIVVTYSLHPDLTSAIAKLA.....AE.AGVRSL.IIPGGPSR...-ASVTELKKISEASGMDIEVDE.ICCTLEP...........--NSANRPFAEI..FGSPVLKVKTE.....NG..KI.....AKVDVIKGAPCGSTWYMAKEIVGV.....PVKDAPPKA........GLLIQH...YPCRASRG-----D..MGGIHESGELHKQAFIKALEn........
D7E7H1_METEZ/5-218              .....................................GVITR..GKYGKRLIDTLRSKSDFN--.......................IVTAELPT....KLPEFIDE.P.DVY.FNNldldnkVFKADILITYSLHPDLTSEIARIA.....GR.SGVRAL.IVPGGTSR...-APINELERYSKEYGIHIEVDD.ICCALDS...........--CPETSEFTSI..FGRPALKIKTD.....ER..KI.....TDVDVIRGAPCGSTWYMAENLIGT.....DIKDAASYG........GLLIQQ...YPCRAVRG-----G..KGGIHESAELHKKAIEKAIEk........
F0T7G5_METSL/5-213              .....................................VIVTD..GPYGDRTYDTICEDFETV--.......................FIELEQPDs..mFMDD-VEV.P.EDS.LNE......LRSADLVISYILHPDLVLEMVEQV.....H-.EDVGWI.IVAAWRGE...-----GLKNQLEDYG-NVTCPD.TMCELEE...........NGDPVYDEFVSK..FGRPIVEIKLE.....GN..KV.....VNVDVIRAAPCGSTHYVSREMVGE.....DVNNLPTRA........GLKVQL...FPCRAPKLRLFV-D..ECKKGLASNFHSQAFQEAIDk........
#=GC seq_cons                   ......................................llhc..GpaGcRhhpsltppsshs.........................lhhhchsc....tls-hI-p.P.c-h.Lsc......l.cuDlllshslHPDlshtLschh.....pc.ssscul.Ilsutpsc........pl+cphcphshphhsPc..hCsLcc...........stpshlccFlch..FG+Pcl-lplc.....ss..pl.....pcVcVlRuuPCGoThalA+clhGh.....plp-ht.ps........uhthpp...YPChAuhth..p.s..-shhHpAGhlt+cAlccAltp........
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