GenomeNet

Database: Pfam
Entry: p31comet
LinkDB: p31comet
Original site: p31comet 
#=GF ID   p31comet
#=GF AC   PF06581.7
#=GF DE   Mad1 and Cdc20-bound-Mad2 binding
#=GF PI   DUF1135;
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_19462 (release 10.0)
#=GF GA   24.10 24.10;
#=GF TC   24.20 25.50;
#=GF NC   23.80 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18022368
#=GF RT   p31comet blocks Mad2 activation through structural mimicry.
#=GF RA   Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H, Luo X;
#=GF RL   Cell. 2007;131:744-755.
#=GF DR   INTERPRO; IPR009511;
#=GF CC   This family is involved in the cell-cycle surveillance mechanism
#=GF CC   called the spindle checkpoint. This mechanism monitors the
#=GF CC   proper bipolar attachment of sister chromatids to spindle
#=GF CC   microtubules and ensures the fidelity of chromosome segregation
#=GF CC   during mitosis. A key player in mitosis is Mad2, and Mad2
#=GF CC   exhibits an unusual two-state behaviour. A Mad1-Mad2 core
#=GF CC   complex recruits cytosolic Mad2 to kinetochores through Mad2
#=GF CC   dimerisation and converts Mad2 to a conformer amenable to Cdc20
#=GF CC   binding. p31comet inactivates the checkpoint by binding to Mad1-
#=GF CC   or Cdc20-bound Mad2 in such a way as to stop Mad2 activation and
#=GF CC   to promote the dissociation of the Mad2-Cdc20 complex [1].
#=GF SQ   64
#=GS H0ZFY8_TAEGU/1-213    AC H0ZFY8.1
#=GS G1PV63_MYOLU/13-277   AC G1PV63.1
#=GS G1NEK0_MELGA/1-223    AC G1NEK0.1
#=GS F1RRH8_PIG/1-260      AC F1RRH8.1
#=GS H3C2M4_TETNG/1-220    AC H3C2M4.1
#=GS G3WQ33_SARHA/9-269    AC G3WQ33.1
#=GS H2SQT3_TAKRU/1-219    AC H2SQT3.1
#=GS B4PL51_DROYA/15-157   AC B4PL51.1
#=GS H0XGJ3_OTOGA/17-277   AC H0XGJ3.1
#=GS MD2BP_MOUSE/13-276    AC Q9DCX1.2
#=GS C5EWY0_9FIRM/1-58     AC C5EWY0.1
#=GS F7GBN0_MACMU/28-293   AC F7GBN0.1
#=GS E2BEH8_HARSA/10-208   AC E2BEH8.1
#=GS F7CS13_MOUSE/19-282   AC F7CS13.1
#=GS Q5I0J2_RAT/13-277     AC Q5I0J2.1
#=GS Q5DU48_MOUSE/20-283   AC Q5DU48.1
#=GS H3A6E1_LATCH/182-419  AC H3A6E1.1
#=GS F7ID08_CALJA/28-293   AC F7ID08.1
#=GS B3RK76_TRIAD/20-237   AC B3RK76.1
#=GS G1SP47_RABIT/17-281   AC G1SP47.1
#=GS Q3U0U3_MOUSE/13-276   AC Q3U0U3.1
#=GS F6UQ34_ORNAN/1-238    AC F6UQ34.1
#=GS G3RQP3_GORGO/41-306   AC G3RQP3.1
#=GS G7P3Z9_MACFA/42-306   AC G7P3Z9.1
#=GS G3H4M3_CRIGR/1-148    AC G3H4M3.1
#=GS G1KJQ0_ANOCA/1-237    AC G1KJQ0.1
#=GS E7F9G1_DANRE/147-385  AC E7F9G1.1
#=GS F7HBS7_MACMU/10-274   AC F7HBS7.1
#=GS MD2BP_HUMAN/10-274    AC Q15013.1
#=GS MD2BP_HUMAN/10-274    DR PDB; 2QYF B; 54-272;
#=GS MD2BP_HUMAN/10-274    DR PDB; 2QYF D; 54-273;
#=GS G1QUU8_NOMLE/10-274   AC G1QUU8.1
#=GS F6SN09_HORSE/10-274   AC F6SN09.1
#=GS H2R790_PANTR/41-306   AC H2R790.1
#=GS Q9CY15_MOUSE/13-276   AC Q9CY15.1
#=GS F7G0F1_MONDO/1-259    AC F7G0F1.1
#=GS H9I230_ATTCE/3-188    AC H9I230.1
#=GS F1PC06_CANFA/17-281   AC F1PC06.1
#=GS F7IFH1_CALJA/23-287   AC F7IFH1.1
#=GS A7RJ75_NEMVE/14-239   AC A7RJ75.1
#=GS F7IFH3_CALJA/5-269    AC F7IFH3.1
#=GS H2M980_ORYLA/96-248   AC H2M980.1
#=GS G4VCX5_SCHMA/3-185    AC G4VCX5.1
#=GS H3JC34_STRPU/8-219    AC H3JC34.1
#=GS F1NAI3_CHICK/1-223    AC F1NAI3.1
#=GS G2HHG8_PANTR/74-337   AC G2HHG8.1
#=GS E9PAT7_HUMAN/41-306   AC E9PAT7.1
#=GS G3UEZ1_LOXAF/22-284   AC G3UEZ1.1
#=GS F4QE24_DICFS/35-146   AC F4QE24.1
#=GS G3NL24_GASAC/4-235    AC G3NL24.1
#=GS F1SIT2_PIG/14-277     AC F1SIT2.1
#=GS F1RRH5_PIG/10-274     AC F1RRH5.1
#=GS H0VKM8_CAVPO/17-281   AC H0VKM8.1
#=GS F4WDK2_ACREC/3-188    AC F4WDK2.1
#=GS G3IL35_CRIGR/13-276   AC G3IL35.1
#=GS G1QUU3_NOMLE/30-295   AC G1QUU3.1
#=GS G3RYZ5_GORGO/28-292   AC G3RYZ5.1
#=GS E2AWT1_CAMFO/11-207   AC E2AWT1.1
#=GS D2GZB1_AILME/1-263    AC D2GZB1.1
#=GS Q148D4_BOVIN/10-274   AC Q148D4.1
#=GS G7MPF4_MACMU/41-306   AC G7MPF4.1
#=GS H2PL91_PONAB/10-274   AC H2PL91.1
#=GS G9K966_MUSPF/1-253    AC G9K966.1
#=GS G5BNN2_HETGA/55-318   AC G5BNN2.1
#=GS C3XR20_BRAFL/1-224    AC C3XR20.1
#=GS G1M0C0_AILME/18-282   AC G1M0C0.1
H0ZFY8_TAEGU/1-213               ........................................v-----------------------.----------------------.--AVAFPGAVCRGSGCRFTCELLKHVLHQRNQLPLPYEQLAFFCRR...AA.....QD..GDGIGKP..HSLG--LA....RRKCQQLLMELEGLF...QHL.E.VMFSL.TL.VPRVLFLLGGNVMNPKELYELNL..E.GFCEGS...A...EESL.DTAPC........VRQLFHRLFVADVFSEL.KALPITGT...LVLVQ.GHRDCGVEWFRPKLNYQVPTRGRKLTVKL..S.....C....-...R.PS.....L........P......-......-.......A..W..EDYVWFQAPVTLKGFSE..............................
G1PV63_MYOLU/13-277              .........................................SLTAAPGLEWYEEAEDTHAPHIElLDTT--AAQELPSRSESFRPRHgLVPVVFPGPVSQDGCCQFTCEFLKHVMYQRLQLPLPYEQLKHFYRQ..sSP.....QA..EDMVKKK..PWAITEAS....SRKCQQTLEELESVL...SHL.E.SLFAR.TL.VPRVLILLGGSVLNPKEFYELDL..S.RLAPSN...V...DQRV.STAAC........LRLIFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPIRGHKLTVTL..S.....C....G...R.PS.....I........P......V......T.......A..W..EDYIWFQAPVTLKGFHE..............................
G1NEK0_MELGA/1-223               ........................................v-----------------------.----------------------.--SVVFPGAVSRESCCRFACELLKHVLHQRHQLPLPYEQLAYFCRR...AA.....QD..GDVIKKT..PSV--GLA....NKKCQQVLVELEAVL...QHL.E.VMFSL.TL.VPRVLILLGGNVVSPKELYELNL..E.GICVGS...A...EKSL.KTTSC........VRKLFHSLFIADVFSEL.KALPVTST...VVMLQ.GHRNCGVEWFRPKLNYKVPTRGRKLTVNL..S.....C...dG...D.VD.....I........S......AsapqimT.......S..W..EDYVWFQAPVTLKGFHE..............................
F1RRH8_PIG/1-260                 .......................................lg-------LEWCEKSEETHDPQIElLETT--SAQEPPNPSEPLRPRDcMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDMVKKK..PRATAEAS....NRKCQQTLVELESVL...SHL.E.GLFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPNS...M...DPSL.STAAC........LRRLFRAIFMADAFSEL.QVPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...Q.PA.....I........P......T......T.......A..W..EDYIWFQAPVTLKGFHE..............................
H3C2M4_TETNG/1-220               ........................................i-----------------------.----------------------.----VFPGTVTQEACCRFVSEILKCVLYQRQQLPMTYDQLVY-SQK...KQ.....QE..KHAESRR..AGQSADLA....WRRCQQTLQELQEVL...QQL.E.VLFSL.SR.VPRVLLLLGGSVILPKELYEINM..E.ELVVAS...R...DQCL.RVSSC........LRQLFRNLFVADLLSDT.RPVRLMPT...TVLAL.AHRNCGVEWFHPKLQFKVPTRVKNRVITL..S.....T....D...S.SS.....H........K......D......Mkq..nslD..W..QDYVWFQAPLTIKGFS-k.............................
G3WQ33_SARHA/9-269               .....................................kiaq----LSELERIEDSEGSCASQTE.LLES-ASAHGPSSNPEHLCPGDsMVPVVFPGPVSSEGCCRFACELLKHIMYQRQQLPLPYDQLTVFYSK..pSP.....QA..EDIVKKK..A----ERS....YKKFQQALVELEGIL...SHL.E.SLFAR.TL.VPRVLILLGGNALCPKEFYELDL..A.RLTLGR...M...GQSL.STSAC........LRRLFRALFMADAFSEL.KAAPAMGT...IVMAQ.GHRECGEDWFRPKLNYQVPKRGHKLTVTL..S.....C....G...G.PP.....I........P......D......S.......T..W..DDYIWFQAPVTLKGFRE..............................
H2SQT3_TAKRU/1-219               ........................................v-----------------------.----------------------.--DVIFPGTVTQDGCCRFVSEILKCILYQRQQLPMTYDQLVY-SQK...KQ.....QE..KHAGSRR..PGQSADLA....WRKCQQTMQELEEVL...QQL.E.VLYSL.SR.VPRVLLLLGGSVILPKELYEINM..E.ALVVAS...G...DRCL.RVSSC........LRQLFRTLFVADLLSDT.RPVRLMPT...TVLVL.AHRNCGVEWFRPKLQFKVPTRVKKQVISL..S.....T....D...S.RS.....H........K......E......L.......TpdW..QDYVWFQAPMTIKGFN-k.............................
B4PL51_DROYA/15-157              ..................................ievltsg-----------------------.----------------------.-------------TTAEFVNGILDFLLYQRRQIPFVYKTYKYYVDK...WS.....EA..DESGQSKdqESFAHYQR....NQQRSKAKATKESISdmrEVI.R.QAFRS.SE.VKSLRFLFGNNTFMPSEVYTLHI..-.------...-...----.-----........-----------------.--------...-----.-----------------------------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------phdsisrdhycehhalpegrinqallrllt
H0XGJ3_OTOGA/17-277              .........................................SPAVVRDLEWYEKSEETQAPQVElLET----TQEPPNPSESFCPRDfMIPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSL.....QA..EEMVRKK..SWA--EVT....SKKCQQALAELESVL...SHL.E.GLFAR.TL.VPRVLILLGGSALCPKEFYELDL..S.RLAPNS...M...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPTRGHKLTVTL..S.....C....G...R.PS.....I........Q......T......T.......A..W..EDYIWFQAPVTLKGFHE..............................
MD2BP_MOUSE/13-276               .........................................SPAAAPNLDWYEKPEETHAPEVD.LETVIPPAQEPSNPAEPFCPRD.LVPVVFPGPVSQEDCCQFTCELLKHILYQRHQLPLPYEQLKHFYRK...VP.....QA..EDTARKK..AWLATEAR....NRKCQQALAELESVL...SHL.R.DFFAR.TL.VPQVLILLGGNALSPKEFYELDL..S.RLAPFG...V...DQGL.NTAAC........LRRLFRAIFLADPFSEL.QTPPLMGT...IVMVQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....V........P......A......M.......A..S..EDYIWFQAPVTLKGFHE..............................
C5EWY0_9FIRM/1-58                .........................................-------MDWYEKPEETHAPEVD.LETVIPPAQEPSNPAEPFCPRD.LVPVVFPGPVSQEDCCQFA---------------------------...--.....--..-------..--------....---------------...---.-.-----.--.-----------------------..-.------...-...----.-----........-----------------.--------...-----.-----------------------------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------a.............................
F7GBN0_MACMU/28-293              ......................................sas--AGIIDLEWYEKSEETHASQIElLETS--STQEPLNPSEPFCPRDcIVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKNFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQAVAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNSLSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
E2BEH8_HARSA/10-208              ...................................tdidvl-----------------------.----------------------.-----LDEPLTSESCTKVVIELIKYILYQKQQIPFAYEALAQFQ-K...SM.....KA..TDRN--T..VPFKT---....------LTNTLKSVS...DNLfS.QFFLK.GCdMQEIAILIGATLSSPKLCIRIEL..P.SYVLNS...KqheEYQH.SSRKP........LVKLMRSMLECDEFQTA.MSIPISATn.tFIMLKkKDSNPISDFFIPKPQYVIPTQTTSFNIRL..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------cqsnqvniqctc..................
F7CS13_MOUSE/19-282              .........................................SPAAAPNLDWYEKPEETHAPEVD.LETVIPPAQEPSNPAEPFCPRD.LVPVVFPGPVSQEDCCQFTCELLKHILYQRHQLPLPYEQLKHFYRK...VP.....QA..EDTARKK..AWLATEAR....NRKCQQALAELESVL...SHL.R.DFFAR.TL.VPQVLILLGGNALSPKEFYELDL..S.RLAPFG...V...DQGL.NTAAC........LRRLFRAIFLADPFSEL.QTPPLMGT...IVMVQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....V........P......A......M.......A..S..EDYIWFQAPVTLKGFHE..............................
Q5I0J2_RAT/13-277                .........................................SPAAAPNLDWTEKPEETRAPGVD.LETVIPPVQEPSNSVEPFCPRD.LVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYQK..sSP.....QA..EDTARKK..PRLTTEAS....NRKCQQALAELESVL...SHL.R.DFFAR.TL.VPQVLILLGGNALSPKEFYELDL..S.RLAPFS...V...DQGL.NTAAC........LRHLFRAIFLADAFSEL.QAPPLMGT...IVMVQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....V........P......A......M.......A..S..EDYIWFQAPVTLKGFHE..............................
Q5DU48_MOUSE/20-283              .........................................SPAAAPNLDWYEKPEETHAPEVD.LETVIPPAQEPSNPAEPFCPRD.LVPVVFPGPVSQEDCCQFTCELLKHILYQRHQLPLPYEQLKHFYRK...AP.....QA..EDTARKK..AWLATEAR....NRKCQQALAELESVL...SHL.R.DFFAR.TL.VPQVLILLGGNALSPKEFYELDL..S.RLAPFG...V...DQGL.NTAAC........LRRLFRAIFLADPFSEL.QTPPLMGT...IVMVQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....V........P......A......M.......A..S..EDYIWFQAPVTLKGFHE..............................
H3A6E1_LATCH/182-419             ............................rrssedrsldgcs-----------------------.----------------------.-IPVVFPGHVTQDSCCKFVCEVFKHVLYQRQQLPLPYEQLLYFQRKq.qLN.....QN..EEVVKKS..RWF--ESG....DKKSQKVLLELKEIF...VNL.E.TLFSL.TL.VPRVLILLGGSVICPKELYEINM..E.GISLGN...G...EQSL.KTDPC........VRKLFHTLFVSDAFSDL.KSVPAASV...VVMVQ.AHRDCGIEWFRPKMNYKVPSRGKRLSITL..L.....C....S...N.VQ.....A........D......S......TlkhriklK..R..ENYVWFQAPVAIKGFH-y.............................
F7ID08_CALJA/28-293              .....................................srva---GITDLEWYEKSGETHASQIElLETT--STQEPPNPLEPFCPRDcMVPVVFPGPVSQEGCSRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QT..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPYS...V...DQSL.STAAC........LRHLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
B3RK76_TRIAD/20-237              .............................fesqkwdaetkt-----------------------.----------------------.----------------KLVTGIIQLVLYHRHQIPAPIELLA---RE...KP.....VV..DKDKDDK..-RGLPNQS....AKPLLNLLTALEELS...LHL.S.PIFDS.NV.IQEMLVLLGPTIFSPKCVYRINF..DcREDQIV...L...NLPFpKPEVI........SRQLMLKLSTHEDFSMC.KSFPVTNL...FLFIK.LPRYTNIPWLLPRQDFKLRSQLKPFIIDIvlHp...dL....Q...K.PEkntadA........K......V......T.......D..K..NDMIWFQVPT-------isi...........................
G1SP47_RABIT/17-281              .........................................SPAAGTDLEWFDQSEEIHGSPVE.LPET-ASAPEAPGSAEHCCPRDcMVPVVFPGPVSREGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDVVRKK..PRTAAEAS....SRKCQQALAELESVF...SHL.E.GLFAR.TL.VPRVLILLGGSALSPKEFYELDL..S.RLAPYS...V...DQSL.NTAAC........LRRLFRAIFLADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVSL..S.....C....G...R.PS.....D........P......T......V.......A..S..DDYIWFQAPVTLKGFHE..............................
Q3U0U3_MOUSE/13-276              .........................................SPAAAPNLDWYEKPEETHAPEVD.LETVIPPAQEPSNPAEPFCPRD.LVPVVFPGPVSQEDCCQFTCELLKHILYQRHQLPLPYEQLKHFYRK...AP.....QA..EDTARKK..AWLATEAR....NRKCQQALAELESVL...SHL.R.DFFAR.TL.VPQVLILLGGNALSPKEFYELDL..S.RLAPFG...V...DQGL.NTAAC........LRRLFRAIFLADPFSEL.QTPPLMGT...IVMVQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....V........P......A......M.......A..S..EDYIWFQAPVTLKGFHE..............................
F6UQ34_ORNAN/1-238               .........................................-----------------------.-----PSAKESERTVDHPGPGDsVVPVVFPGPVGRGGCCRFVCELLKHIMYQRQQLPLPYEQLALFYRK..pSP.....QA..EDVARRK..ARAATEPS....SRKCQQALAELEGLT...SRL.E.RFFSR.TP.VPRVLILLGGSALNPKEFYELDL..A.RLSWGA...G...EGSP.SIPAC........LRRLFRALFLADAFSEL.QAAPAMGT...LVMAQ.GHRECGEDWLRPKLNYRVPTRGRKLTLTL..S.....S....E...G.GD.....G........P......D......W.......A..W..DDYVWFQAPLTLRGFRE..............................
G3RQP3_GORGO/41-306              ....................................sqvae----IIDLEWYEKSQETHASQIElLETS--STQEPLNASEAFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...VVMAQ.GHRNCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
G7P3Z9_MACFA/42-306              .......................................qs--AGSTDLEWYEKSEETHASQIElLETS--STQEPLNPSEPFCPRDcIVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKNFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQAVAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNSLSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
G3H4M3_CRIGR/1-148               .........................................-----------------------.----------------------.--------------------------MYQRQQLPLLYEQLD-FYRK..sSP.....LA..EATVRKK..PRITTEVS....SKKCQQTLAELESVL...SHL.E.DFFTR.TL.VPRLLILLGGNALSPKEFYELDL..S.RLVPFS...V...AESL.NTTAC........LRSLFRAIFIADTFSEL.QAPPL---...IVMVQ.EHHDCGEDWFPPKLNY-------------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------..............................
G1KJQ0_ANOCA/1-237               .....................................pawa-----------------------.----------------------.-VSVAFPGSVTQEGCFRFTCEFLKHVLYQRQQLPLPYEQLAFFYRR...QPprapgQAngDEEVVRK..VHVKDQDC....SQKCQQVLSDLEGVF...KHL.E.TMFTL.TL.VPCVLILLGGTSVSPKEFYEINL..Q.GVSVRG...A...EDSL.QTAAC........IRKLFHSLFLADVFSEL.QTGPTMGV...TVMVQ.GHRNCGVDWFKPKLNYKVPTRGRKLTVNV..S.....C....S...H.HT.....StglsdyqeM......N......S.......A..W..DDYIWFQAPVTVKGFR-y.............................
E7F9G1_DANRE/147-385             .........................svddeeifrrareegr-----------------------.----------------------.-VNVIFPGCITQDGCCRFVGELLKCVLYQRQQMPMTYDQMVFLQKQ..qHN.....AS..QDIIKQR.sAKASGGLD....WRRCQKMLQELDDVL...AHL.E.ALFSL.SR.VPRVLFMLGGSTVLPTELYEVNM..E.SVAVGA...G...ENSL.RTSTC........LRQIFRTLFVADLLSDA.KSVRLMST...TVLAL.GHRDCGVTGFKPRVDFKVPTKVKRQVISI..G.....S....DlslA.GE.....L........P......K......T.......D..L..EDYIWFQAPVTVKGF--ck............................
F7HBS7_MACMU/10-274              .........................................SPASVPDLEWYEKSEETHASQIElLETS--STQEPLNPSEPFCPRDcIVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKNFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQAVAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNSLSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
MD2BP_HUMAN/10-274               .........................................SSAAVPDLEWYEKSEETHASQIElLETS--STQEPLNASEAFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...VVMAQ.GHRNCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTFKGFRE..............................
#=GR MD2BP_HUMAN/10-274    SS    .........................................XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXX-EEEEE-SS---HHHHHHHHHHHHHHHHHHTTSSSS-HHHHT-XXXX..XXX.....XX..XXXXXXX..XXXXXX-H....HHHHHHHHHHHHHHH...HHH.H.HHHHH.S-.--EEEEEESS-SSS-SEEEEEE-..T.TS-XXX...X...XXXS.HHHHH........HHHHHHHHHHTTTT---.S-----EE...EEEEE.EECCC--SSSEEETT----SS-EEEEEEE..E.....-....S...-.--.....-........-......T......T.......T..T..TTEEEEE-SS-EE---X..............................
G1QUU8_NOMLE/10-274              .........................................SPAAVPDLEWYEKSEETHASQIElLETG--STQEPLNPSESFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..SWATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......M.......A..W..EDYIWFQAPVTLKGFRE..............................
F6SN09_HORSE/10-274              .........................................SPAAVPDLEWYEKSEETHAPQIElLETT--SAPQPPNPSEPFCPRDcMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDVVKKK..PRATADMG....SRKCQQALAELESVF...SHL.E.GLFAR.TL.VPRVLILLGGSAVSPKEFYELDL..S.RLAPNS...M...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.AS.....I........P......A......T.......A..W..EDYIWFQAPVTLKGFHE..............................
H2R790_PANTR/41-306              ....................................sqvae----IIDLEWFEKSEETHASQIElLETS--SMQEPLNASEAFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...VVMAQ.GHRNCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
Q9CY15_MOUSE/13-276              .........................................SLVVAQILIGFKKPEKTIALEVN.FEIVFPPAKKLSILGEPFCPKN.LGPGGFPGLVTQKNCCQFIWKLLKLFLSQRLKFLLPYKQLNHFYRK...VP.....QP..KDPPGKK..VWFAPEAR....NRKCHQVLADLESVL...IHL.Q.NFFAR.TL.FQKGLIFFEGNALSLKKFFELDL..S.RLVQFG...V...DQGL.NTGVC........LRRLFRAFFLADPFSEL.QTPPLMGT...IVMVQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....V........P......A......M.......A..S..EDYIWFQAPVTLKGFHE..............................
F7G0F1_MONDO/1-259               ......................................aql-----SELEGIEESEESCAPQREqLEST--STHDPSSNPEHLCPGDsLVPVVFPGPVNSEGCCRFACELLKHIMYQRQQLPLPYDQLTVFYSK..pSP.....QA..EDMMRKK..A----ERS....YRKFQQALLELEGIL...SHL.E.SLFAR.TL.VPRVLILLGGSALCPKEFYELDL..A.RLALGR...M...GQSL.STSAC........LRRLFRALFMADAFSEL.KAAPAMGT...IVMAQ.GHRECGEDWFRPKLNYQVPKRGHKLTVTL..S.....C....G...G.PP.....I........P......D......S.......A..W..DDYIWFQAPVTLKGFRE..............................
H9I230_ATTCE/3-188               ...................................idvmld-----------------------.----------------------.-------EPWTSDSCTKVVMELIKYILYQKQQIPLTYEALERFQNT...TD.....R-..-----NA..------VS....FKALSSTLKNIEDHL...SS-.-.QFFLKgCD.MKEVAIILGATILSPKFYIGIDL..P.SYVLNS...KqhkEYQH.SSRKP........LLKLMRSMFECDEFQKA.MNAPLNMTnmfIMLKK.SDNNSVSDFFLPKPQYVPP----------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------iqtagcfkiklcqs................
F1PC06_CANFA/17-281              ........................................c-PAAVPDLEWYEKSEETHAPQIElLETT--STQEPPNPSEPFYPRNcMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDAMKKK..ARAAAEMS....SRKCQQALAELESVL...SHL.E.GLFAR.TL.VPRVLILLGGSALSPKEFYELDL..S.RLAPNS...M...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPNRGHKLTVTL..S.....C....G...R.SS.....I........P......T......T.......A..W..EDYVWFQAPVTLKGFHE..............................
F7IFH1_CALJA/23-287              .......................................ea--ASVPDLEWYEKSGETHASQIElLETT--STQEPPNPLEPFCPRDcMVPVVFPGPVSQEGCSRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QT..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPYS...V...DQSL.STAAC........LRHLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
A7RJ75_NEMVE/14-239              .................................sleendsr-----------------------.----------------------.------------EVKAQLLIVFIKHLLHDRFQVPCTIDQIRSEAEE...-E.....SS..KAGQTKK..TGLSTDIT....-KKRDKIITDLDILF...KNL.E.ELFAT.AD.VASVVVIYGSTAVSPKESYILQFdaN.SSNSFT...L...SSSN.KENLCssgltnrlCRKLIRALISNPVLSKF.QEIPLTPM...LVFVS.VPRTVKNYWFRPKPSFKVPWRGNRFRISV..S.....S....S...SvQD.....L........P......S......Q.......S..SdqDELIWMQAPITIKGFR-l.............................
F7IFH3_CALJA/5-269               .......................................ea--ASVPDLEWYEKSGETHASQIElLETT--STQEPPNPLEPFCPRDcMVPVVFPGPVSQEGCSRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QT..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPYS...V...DQSL.STAAC........LRHLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
H2M980_ORYLA/96-248              teihqeeqqeeeeatscqesaserhsntqdrdaevvrrake-----------------------.--------------------EG.CVSVIFPGPVTQDGSYRFVSEILKCVLYQRQQLPMTYEQLV-FSQK...RQ.....QQ..RDVEDKD..VVRPRKVHsadvDYKCQQTLQELEEVL...HQL.E.VLFSL.SR.VPRVLLMMGGSLVLP--------..-.------...-...----.-----........-----------------.--------...-----.-----------------------------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------k.............................
G4VCX5_SCHMA/3-185               ..............................fcclpvgvnhf-----------------------.----------------------.----------SLDERCNLICRIMKLFMYFTGQFPD----LS--LLN...PP.....QN..ESDSEIK..LQDSLHSK....EVKLLQSIQEVESNL...LSS.K.S---E.S-.IFYFLIMIGGVPSSPKRAFLIDI..N.DFYPKT...I...NVNK.TDIVS........FREFFESLVQVPFFDNVfKCSTPTRT...YIYIC.TSKDFSSSWFLPRLQFRLPR---------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------tcpvhvlkiv....................
H3JC34_STRPU/8-219               ...................................gstcni-----------------------.----------------------.----SLNGFVTQTIKSRIVTEILKYLLYHREQIPLPFDQLYFQYER...-P.....EV..QSNDNKH..TLF-----....KKRMTQLLKESQDLF...VNI.D.SLFQD.TD.VSHIIVLLGSTVISPKEVYHIR-..-.FLNNEQ...T...AQTL.SVKHC........VRSVARSLITSSPLGDS.PLPPLTNM...VITAH.APRSCNPTWFKPKANFKVPKMGRHCNIDI..S.....C....G...M.MH.....S........R......-......V.......S..S..EEHIWMQTPSGIKGLK-d.............................
F1NAI3_CHICK/1-223               ........................................v-----------------------.----------------------.--SVVFPGAVSRESCCRFACELLKHVLHQRHQLPLPYEQLAYFCRR...AA.....QD..GDVIKKP..PSVG--LA....SKKCQQVLVELEGVL...QHL.E.AMFSL.TL.VPRVLILLGGNAVSPKELYELNL..E.GICVGS...A...EKSL.KTTSC........VRKLFHSLFIADVFSEL.KALPITGT...VVMLQ.GHRNCGAEWFRPKLNYKVPTRGRKLTINL..S.....C...dG...D.VD.....I........SasaqtvT......S.......A..W..EDYIWFQAPVTLKGFHE..............................
G2HHG8_PANTR/74-337              ......................................tky----VHDLEWFEKSEETHASQIElLETS--SMQEPLNASEAFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...VVMAQ.GHRNCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
E9PAT7_HUMAN/41-306              ....................................sqvae----IIDLEWYEKSEETHASQIElLETS--STQEPLNASEAFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...VVMAQ.GHRNCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTFKGFRE..............................
G3UEZ1_LOXAF/22-284              .........................................SSAHVPDLEWYDKAEETHVPQIElLETT--SVQGPLNPSEQFGPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK...PP.....QT..EDVVRKK..PRTATETN....SKKCQQALAELESVF...NHL.E.VLFAR.TL.VPRVLILLGGSALSPKEFYELDL..S.RLVPDS...R...EQSL.NTAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PP.....I........P......T......T.......A..W..EDYIWFQAPVTLKGFH-..............................
F4QE24_DICFS/35-146              ...................................selytt-----------------------.----------------------.-----------------VVKEIIKYLFYMRNQIKLPYNDFERLYSP...IT.....NN..KDDNVEK..KII--KKI....PKKCMIALSSCNQLF...GSL.GiDFNSG.NY.YEKVVIIFGNSIMAPKEIYIINV..P.RLS---...-...----.-----........-----------------.--------...-----.-----------------------------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------hedmlc........................
G3NL24_GASAC/4-235               ...................................aqdegr-----------------------.----------------------.-VNVVFPGTVTQDGCCRFVSEILKCILYQRQQLPMTYDQLVYSQKKrqaSM.....QD..KDIVSRR..PVQAEDMD....WRKSQQTLQELEEVL...QQL.E.VLFSL.SR.VPRVLLIMGGSLVLPKELYEINM..E.ALILAG...G...DESL.RVSSC........LRQLFHTLFVADLLSDS.RPIRLMPT...TVLAM.AHRDCDVGWFRPKLQFKMPTRVKHQIIAL..StapsdC....K...E.PR.....A........Q......G......P.......D..W..TDYVWFQAPMTIKGF--gk............................
F1SIT2_PIG/14-277                ....................................ppppt------GLEWCEKSEETHDPQIElLETT--SAQEPPNPSEPLRPRDcMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDMVKKK..PRATAEAS....NRKCQQTLVELESVL...SHL.E.GLFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPNS...M...DPSL.STAAC........LRRLFRAIFMADAFSEL.QVPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...Q.PA.....I........P......T......T.......A..W..EDYIWFQAPVTLKGFHE..............................
F1RRH5_PIG/10-274                .........................................SPVAVSGLEWCEKSEETHDPQIElLETT--SAQEPPNPSEPLRPRDcMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDMVKKK..PRATAEAS....NRKCQQTLVELESVL...SHL.E.GLFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPNS...M...DPSL.STAAC........LRRLFRAIFMADAFSEL.QVPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...Q.PA.....I........P......T......T.......A..W..EDYIWFQAPVTLKGFHE..............................
H0VKM8_CAVPO/17-281              .......................................pp--ASVPDLEWYDKSEDASAPQIDlLEAH--SVQEPPNPSETFCPRDcLVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKRFYRR..tSP.....QT..EDIVRKK..PRTASEAS....SRKCQQALAELDSVL...SHL.E.DLFAR.TL.IPRVLILLGGSVISPKEFYELDL..S.RLAPLS...M...DQSL.STAAC........LRRLFRAIFLADAFSEL.QAPPLMGT...IVMVQ.GHRDCGEEWFRPKLNYRVPTRGHKLTVTL..S.....C....G...R.PS.....V........P......A......L.......A..S..EDYIWFQAPVMLKGFHE..............................
F4WDK2_ACREC/3-188               ...................................idvmld-----------------------.----------------------.-------EPWTSDSCTKVVMELIKYILYQKQQIPLTYEALERFQNT...TD.....R-..-----NA..------VS....FKALSSTLKNVEDHL...S--.S.QFFLKgCD.MKEVAIILGATILSPKFYIGIDL..P.SYVLNS...KqhkEYQH.SSRKP........LLKLMRSMFECDEFQKA.MNAPLNITnmfIMLKK.SDNNLVSDFFLPKPQYVPPV---------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------qtagcfkiklcqs.................
G3IL35_CRIGR/13-276              ........................................a-PVAVPDLDWYEKPEETHAPQID.PETAITPPQEPSNPPEPFCPRD.LVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKNFYRK...SP.....QA..EATVRKK..PRITTEVS....SKKCQQTLAELESVL...SHL.E.DFFTR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPFS...V...DESL.NTAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMVQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........P......A......M.......A..S..EDYIWFQAPVTLKGFHE..............................
G1QUU3_NOMLE/30-295              .....................................sgva---GTTDLEWYEKSEETHASQIElLETG--STQEPLNPSESFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..SWATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......M.......A..W..EDYIWFQAPVTLKGFRE..............................
G3RYZ5_GORGO/28-292              .........................................SSAAVPDLEWYEKSQETHASQIElLETS--STQEPLNASEAFCPRDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...VVMAQ.GHRNCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
E2AWT1_CAMFO/11-207              ..................................eidimld-----------------------.----------------------.-------EPLTNDSCTKVVIELVKYILYQKQQIPFAYEALARFQTS...VK.....AT..-D--RNA..VSF-----....-KTLSSMLKDVSDQL...F--.S.QFFLKgCD.VKEVAILLGPTILSPKLCIAIEF..P.SYILNSkqhK...EYQH.SSRKP........LLKLMRSLLECDEFQEA.MNIPLSMTnmfIMLKK.NDGNSASDFFLPKPQYILPTQQ-------..-.....-....-...-.--.....-........-......-......-.......-..-..-----------------stscfriklgqsdqvnie............
D2GZB1_AILME/1-263               .....................................ahll------DLEWYEKSEETHAPQIElLETT--STQEPPKPSEPFCPRDcLVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDATKKK..ARATAEVS....SRKCQQALAELESVL...SHL.E.GLFAR.TL.VPRVLILLGGSALSPKEFYELDL..S.RLAPNS...M...EQSP.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPTRGHKLTVVL..S.....C....G...R.PS.....V........P......A......A.......A..W..EDYIWFQAPVTLKGFHE..............................
Q148D4_BOVIN/10-274              .......................................pp--ATVPDLEWCEKSEETQDPQIElLETT--STQEPPNPLEPFRPRDcMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pFP.....QA..EDVVKKK..PRATAEVS....SRKCQQTLAELESVL...SHL.E.GLFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.RLAPNS...M...DPSL.STAAC........LRRLFRAIFLADAFSEL.QVPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSRGHKLTVTL..S.....C....G...R.PA.....I........P......A......T.......T..W..EDYIWFQAPLTLKGFHE..............................
G7MPF4_MACMU/41-306              .....................................sqva---EIMDLEWYEKSEETHASQIElLETS--STQEPLNPSEPFCPRDcIVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKNFYRK..pSP.....QA..EEMLKKK..PRATTEVS....SRKCQQAVAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNSLSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IIMAQ.GHRDCGEDWFQPKLNYRVPSRGHKLTVTL..S.....C....G...R.PS.....I........R......T......T.......A..W..EDYIWFQAPVTLKGFRE..............................
H2PL91_PONAB/10-274              .........................................SSAAVPDLEWYEKSEETHASQIElLETS--STQEPLNASESFCPGDcMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EEILKKK..PRANTEVS....SRKCQQALAELESVL...SHL.E.DFFAR.TL.VPRVLILLGGNALSPKEFYELDL..S.LLAPYS...V...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPSQGHKLTVTL..S.....C....G...R.PS.....I........R......T......M.......A..W..EDYIWFQTPVTLKGFRE..............................
G9K966_MUSPF/1-253               .........................................-----------EKSEETHAPQIElLETT--STQEPPNPSEPFCPRDcMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDAVKKK..ARAAAEVS....SRKCQQALAELESVL...SHL.E.GLFAR.TI.VPRVLILLGGNALNPKEFYELDL..S.RLAPNS...M...DQSL.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPTRGHKLTVTL..S.....C....G...R.PS.....I........P......A......T.......A..W..EDYIWFQAPVTLKGFH-..............................
G5BNN2_HETGA/55-318              .....................................svlg-----LDLKWYEKSEEAPDPQIDlLETH--SAQEPPNPSELFCPRDcLVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..tSP.....QA..EDTARKK..PRTASEAS....SRKCQQALAELDNVL...GHL.E.DLFAR.TL.VPRVLILLGGSAISPKEFYELDL..S.RLAPLS...V...DQSL.STPAC........LRRLFRAIFLADAFSEL.QAPPLMGT...VVMVQ.GHRDCGEEWFRPKLNYRVPTRGHKLTVTL..S.....C....G...R.PS.....V........P......A......L.......G..S..EDYIWFQAPVTLKGFHE..............................
C3XR20_BRAFL/1-224               .......................................vk-----------------------.----------------------.-----IDGLVAPQVCCRLTSELLKYLLYERQQIPLPYEQIKFDLKR..dET.....VR..QETKVCS..DTAVANMH....EKRCKHVVDCMEELL...PHL.E.DLFSL.TF.VPQVLILIGATAVSPKEAYIINF..T.DALTTS...K...ENSL.SAKSC........IRSLLREMVTKDFLPIS.SMPPITNT...ILLVK.AHRDCGLEWFVPKLTYKLGSRGQQYDITL..A.....GtahpG...G.EQ.....V........R......I......Ee....qgP..K..DDYIWYQAPLSIKGYKE..............................
G1M0C0_AILME/18-282              ........................................c-PAAEPDLEWYEKSEETHAPQIElLETT--STQEPPKPSEPFCPRDcLVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRK..pSP.....QA..EDATKKK..ARATAEVS....SRKCQQALAELESVL...SHL.E.GLFAR.TL.VPRVLILLGGSALSPKEFYELDL..S.RLAPNS...M...EQSP.STAAC........LRRLFRAIFMADAFSEL.QAPPLMGT...IVMAQ.GHRDCGEDWFRPKLNYRVPTRGHKLTVVL..S.....C....G...R.PS.....V........P......A......A.......A..W..EDYIWFQAPVTLKGFHE..............................
#=GC SS_cons                     .........................................XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXX-EEEEE-SS---HHHHHHHHHHHHHHHHHHTTSSSS-HHHHT-XXXX..XXX.....XX..XXXXXXX..XXXXXX-H....HHHHHHHHHHHHHHH...HHH.H.HHHHH.S-.--EEEEEESS-SSS-SEEEEEE-..T.TS-XXX...X...XXXS.HHHHH........HHHHHHHHHHTTTT---.S-----EE...EEEEE.EECCC--SSSEEETT----SS-EEEEEEE..E.....-....S...-.--.....-........-......T......T.......T..T..TTEEEEE-SS-EE---X..............................
#=GC seq_cons                    ................................................Lchh-cst-spsspl-.L-p...sspcs.ps.E.hpPcD.hVPVVFPGPVSQEGCCpFTCELLKHIhYQRQQLPLPYEQLKaFYRK...oP.....QA..E-hh+KK..spsssEso....sRKCQQsLuELESVL...SHL.E.shFAR.TL.VPRVLILLGGsALSPKEFYELDL..S.pLuPhS...h...-pSL.oTuAC........LR+LFRAlFhADsFSEL.QuPPLMGT...lVMsQ.GHRDCGEDWFRPKLNYRVPoRGHKLTVTL..S.....C....G...c.Pu.....l...............s......h.......A..h..EDYIWFQAPVTLKGF+E..............................
//
DBGET integrated database retrieval system