GenomeNet

Database: Pfam
Entry: z-alpha
LinkDB: z-alpha
Original site: z-alpha 
#=GF ID   z-alpha
#=GF AC   PF02295.14
#=GF DE   Adenosine deaminase z-alpha domain
#=GF AU   Mian N, Bateman A
#=GF SE   Pfam-B_11136 (release 5.2)
#=GF GA   20.60 20.60;
#=GF TC   20.60 20.70;
#=GF NC   20.20 20.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Z-alpha
#=GF RN   [1]
#=GF RM   10535945
#=GF RT   The solution structure of the Zalpha domain of the human RNA
#=GF RT   editing enzyme ADAR1 reveals a prepositioned binding surface for
#=GF RT   Z-DNA. 
#=GF RA   Schade M, Turner CJ, Kuhne R, Schmieder P, Lowenhaupt K, Herbert
#=GF RA   A, Rich A, Oschkinat H; 
#=GF RL   Proc Natl Acad Sci U S A 1999;96:12465-12470.
#=GF DR   INTERPRO; IPR000607;
#=GF DR   SCOP; 1qgp; fa;
#=GF CC   This family consists of the N-terminus and thus the z-alpha
#=GF CC   domain of double-stranded RNA-specific adenosine deaminase
#=GF CC   (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA
#=GF CC   binding domain, and binding of this region to B-DNA has been
#=GF CC   shown to be disfavoured by steric  hindrance [1].  
#=GF SQ   195
#=GS F1QUI9_DANRE/6-71         AC F1QUI9.1
#=GS H9L3K3_CHICK/28-93        AC H9L3K3.2
#=GS ZBP1_RAT/11-69            AC Q8VDA5.1
#=GS G7NUJ1_MACFA/337-401      AC G7NUJ1.1
#=GS F6TP72_HORSE/239-303      AC F6TP72.1
#=GS A0A096N395_PAPAN/433-497  AC A0A096N395.1
#=GS U3JET5_FICAL/118-182      AC U3JET5.1
#=GS U3IQ81_ANAPL/26-92        AC U3IQ81.1
#=GS G3V8T3_RAT/245-309        AC G3V8T3.1
#=GS F7HS73_CALJA/295-359      AC F7HS73.1
#=GS W5LAV0_ASTMX/389-454      AC W5LAV0.1
#=GS H3C5Q5_TETNG/188-250      AC H3C5Q5.1
#=GS L9KHQ0_TUPCH/182-246      AC L9KHQ0.1
#=GS H2M250_ORYLA/284-348      AC H2M250.1
#=GS H2R1Y2_PANTR/178-244      AC H2R1Y2.1
#=GS L5M6P1_MYODS/203-258      AC L5M6P1.1
#=GS DSRAD_MOUSE/248-312       AC Q99MU3.2
#=GS G3SA86_GORGO/121-185      AC G3SA86.1
#=GS W4XPH4_STRPU/237-297      AC W4XPH4.1
#=GS F7IKG8_CALJA/11-71        AC F7IKG8.1
#=GS F6XT26_CANFA/9-69         AC F6XT26.1
#=GS A0A091D3X5_FUKDA/251-317  AC A0A091D3X5.1
#=GS H9GRT6_ANOCA/228-292      AC H9GRT6.1
#=GS I3MMD8_SPETR/219-282      AC I3MMD8.1
#=GS M7AU33_CHEMY/1-64         AC M7AU33.1
#=GS G1RL51_NOMLE/178-244      AC G1RL51.1
#=GS W4XXD3_STRPU/365-429      AC W4XXD3.1
#=GS G1SVD5_RABIT/110-176      AC G1SVD5.1
#=GS H3C5Q5_TETNG/319-384      AC H3C5Q5.1
#=GS M3VWG8_FELCA/241-305      AC M3VWG8.1
#=GS L5JUV0_PTEAL/135-199      AC L5JUV0.1
#=GS Q8V3R2_SWPV1/8-70         AC Q8V3R2.1
#=GS H9H124_MELGA/119-183      AC H9H124.1
#=GS H0Z0Z8_TAEGU/108-172      AC H0Z0Z8.1
#=GS G3HBY8_CRIGR/138-203      AC G3HBY8.1
#=GS F6QDP5_MONDO/129-194      AC F6QDP5.2
#=GS G7PFS7_MACFA/11-69        AC G7PFS7.1
#=GS M3Y6Y0_MUSPF/270-334      AC M3Y6Y0.1
#=GS H0XBP7_OTOGA/11-71        AC H0XBP7.1
#=GS G3TV03_LOXAF/132-198      AC G3TV03.1
#=GS F6ZDR2_MACMU/11-69        AC F6ZDR2.1
#=GS H2TCA3_TAKRU/249-314      AC H2TCA3.1
#=GS H2R1Y2_PANTR/338-402      AC H2R1Y2.1
#=GS G3PDZ1_GASAC/297-362      AC G3PDZ1.1
#=GS L5JUV0_PTEAL/24-90        AC L5JUV0.1
#=GS DSRAD_HUMAN/295-359       AC P55265.4
#=GS DSRAD_HUMAN/295-359       DR PDB; 1XMK A; 295-359;
#=GS F7GLF8_MACMU/134-200      AC F7GLF8.1
#=GS F6TP72_HORSE/132-195      AC F6TP72.1
#=GS M3Y6Y0_MUSPF/160-227      AC M3Y6Y0.1
#=GS H2N5K5_PONAB/135-201      AC H2N5K5.1
#=GS A0A093BQH7_CHAPE/17-83    AC A0A093BQH7.1
#=GS H2M250_ORYLA/155-215      AC H2M250.1
#=GS G3TIV1_LOXAF/107-173      AC G3TIV1.1
#=GS G3HBY8_CRIGR/249-313      AC G3HBY8.1
#=GS K1PWV0_CRAGI/29-93        AC K1PWV0.1
#=GS F6ZMB0_XENTR/82-148       AC F6ZMB0.1
#=GS G3TIV1_LOXAF/218-282      AC G3TIV1.1
#=GS U3JET5_FICAL/17-83        AC U3JET5.1
#=GS F7HLJ8_CALJA/135-201      AC F7HLJ8.1
#=GS F1PQB2_CANFA/102-168      AC F1PQB2.2
#=GS G3QW58_GORGO/178-244      AC G3QW58.1
#=GS V8NFN1_OPHHA/349-412      AC V8NFN1.1
#=GS H0V5I6_CAVPO/50-114       AC H0V5I6.1
#=GS W4XPH4_STRPU/399-464      AC W4XPH4.1
#=GS E3_VACCW/7-72             AC P21605.1
#=GS G3R5Y8_GORGO/11-70        AC G3R5Y8.1
#=GS F7GLF8_MACMU/293-357      AC F7GLF8.1
#=GS H2TCA4_TAKRU/239-301      AC H2TCA4.1
#=GS A0A087Y9I9_POEFO/404-469  AC A0A087Y9I9.2
#=GS Q08FV9_DPV83/12-76        AC Q08FV9.1
#=GS A0A087Y9I9_POEFO/249-314  AC A0A087Y9I9.2
#=GS E7F3L7_DANRE/253-319      AC E7F3L7.1
#=GS T1J5P4_STRMM/254-316      AC T1J5P4.1
#=GS I1GJ01_AMPQE/274-339      AC I1GJ01.1
#=GS G3SA86_GORGO/10-76        AC G3SA86.1
#=GS A0A0D9S5D2_CHLSB/1-64     AC A0A0D9S5D2.1
#=GS H3DLT9_TETNG/1-40         AC H3DLT9.1
#=GS A0A091D3X5_FUKDA/362-426  AC A0A091D3X5.1
#=GS Q3A9H9_CARHZ/1-49         AC Q3A9H9.1
#=GS G3V6S4_RAT/87-148         AC G3V6S4.1
#=GS Q5NE14_DANRE/6-71         AC Q5NE14.1
#=GS Q5NE14_DANRE/6-71         DR PDB; 4LB5 A; 9-68;
#=GS Q5NE14_DANRE/6-71         DR PDB; 4LB6 B; 9-69;
#=GS Q5NE14_DANRE/6-71         DR PDB; 4LB5 B; 9-69;
#=GS E9QIW2_DANRE/253-319      AC E9QIW2.1
#=GS M3Y5L5_MUSPF/9-69         AC M3Y5L5.1
#=GS H2TCA3_TAKRU/141-204      AC H2TCA3.1
#=GS M3VWG8_FELCA/130-196      AC M3VWG8.1
#=GS H0YCK3_HUMAN/130-196      AC H0YCK3.1
#=GS I3JGJ6_ORENI/242-307      AC I3JGJ6.1
#=GS A0A096N395_PAPAN/178-244  AC A0A096N395.1
#=GS L9KHQ0_TUPCH/45-110       AC L9KHQ0.1
#=GS W5LAU8_ASTMX/243-308      AC W5LAU8.1
#=GS I3M9F2_SPETR/12-70        AC I3M9F2.1
#=GS F6WQ52_HORSE/106-164      AC F6WQ52.1
#=GS G1RL51_NOMLE/289-353      AC G1RL51.1
#=GS A2APF7_MOUSE/11-70        AC A2APF7.1
#=GS H2TCA4_TAKRU/369-434      AC H2TCA4.1
#=GS W5NY89_SHEEP/249-313      AC W5NY89.1
#=GS W4XPH4_STRPU/38-103       AC W4XPH4.1
#=GS W5NY89_SHEEP/138-203      AC W5NY89.1
#=GS M3VUQ8_FELCA/33-84        AC M3VUQ8.1
#=GS G3PDZ1_GASAC/161-225      AC G3PDZ1.1
#=GS G3HBK7_CRIGR/41-97        AC G3HBK7.1
#=GS G1RL52_NOMLE/348-412      AC G1RL52.2
#=GS M3XGS0_LATCH/115-178      AC M3XGS0.1
#=GS W4XXD3_STRPU/202-262      AC W4XXD3.1
#=GS I3M9F2_SPETR/105-164      AC I3M9F2.1
#=GS I3JGJ6_ORENI/391-456      AC I3JGJ6.1
#=GS W5Q7K5_SHEEP/33-94        AC W5Q7K5.1
#=GS T1J5P4_STRMM/7-68         AC T1J5P4.1
#=GS H2QKN2_PANTR/11-69        AC H2QKN2.1
#=GS G5AUM6_HETGA/105-164      AC G5AUM6.1
#=GS G1LYN3_AILME/243-307      AC G1LYN3.1
#=GS DSRAD_RAT/245-309         AC P55266.1
#=GS G7NUJ1_MACFA/178-244      AC G7NUJ1.1
#=GS I3MMD8_SPETR/108-173      AC I3MMD8.1
#=GS ZBP1_MOUSE/87-144         AC Q9QY24.1
#=GS F1MUM9_BOVIN/243-307      AC F1MUM9.2
#=GS DSRAD_MOUSE/137-203       AC Q99MU3.2
#=GS L5M6P1_MYODS/275-332      AC L5M6P1.1
#=GS F1RGM8_PIG/241-305        AC F1RGM8.2
#=GS Q6TUX8_YMTV5/15-74        AC Q6TUX8.1
#=GS H9H124_MELGA/17-82        AC H9H124.1
#=GS F7HS73_CALJA/133-199      AC F7HS73.1
#=GS G1PXF5_MYOLU/133-198      AC G1PXF5.1
#=GS G1SVD5_RABIT/227-291      AC G1SVD5.1
#=GS F1QXK7_DANRE/6-71         AC F1QXK7.1
#=GS E9QIW2_DANRE/411-476      AC E9QIW2.1
#=GS M3XGS0_LATCH/232-296      AC M3XGS0.1
#=GS DSRAD_RAT/137-203         AC P55266.1
#=GS A0A0D2WVC4_CAPO3/7-63     AC A0A0D2WVC4.1
#=GS H0Z0Z8_TAEGU/7-72         AC H0Z0Z8.1
#=GS E7F3L7_DANRE/411-476      AC E7F3L7.1
#=GS F1PQB2_CANFA/211-275      AC F1PQB2.2
#=GS W5LAU8_ASTMX/412-477      AC W5LAU8.1
#=GS I1EJI4_AMPQE/275-340      AC I1EJI4.1
#=GS G3V6S4_RAT/11-69          AC G3V6S4.1
#=GS A0A093BQH7_CHAPE/115-179  AC A0A093BQH7.1
#=GS ZBP1_HUMAN/11-69          AC Q9H171.2
#=GS ZBP1_HUMAN/11-69          DR PDB; 2LNB A; 17-75;
#=GS Q6TVV0_ORFSA/1-65         AC Q6TVV0.1
#=GS F1QQL0_DANRE/253-319      AC F1QQL0.1
#=GS F6WQ52_HORSE/9-61         AC F6WQ52.1
#=GS F6DQV5_DESRL/1-49         AC F6DQV5.1
#=GS ZBP1_MOUSE/11-70          AC Q9QY24.1
#=GS ZBP1_MOUSE/11-70          DR PDB; 1J75 A; 113-169;
#=GS ZBP1_MOUSE/11-70          DR PDB; 2HEO A; 113-170;
#=GS ZBP1_MOUSE/11-70          DR PDB; 2HEO D; 113-169;
#=GS G1LYN3_AILME/132-198      AC G1LYN3.1
#=GS H3B681_LATCH/35-98        AC H3B681.1
#=GS I3MX49_SPETR/12-70        AC I3MX49.1
#=GS I3NBG7_SPETR/82-142       AC I3NBG7.1
#=GS A0A096NNI5_PAPAN/11-69    AC A0A096NNI5.1
#=GS H3DLT9_TETNG/109-174      AC H3DLT9.1
#=GS F6QDP5_MONDO/238-302      AC F6QDP5.2
#=GS G3QW58_GORGO/338-402      AC G3QW58.1
#=GS T1J5P4_STRMM/424-489      AC T1J5P4.1
#=GS T1J5P4_STRMM/148-211      AC T1J5P4.1
#=GS L9L955_TUPCH/101-158      AC L9L955.1
#=GS ZBP1_RAT/87-148           AC Q8VDA5.1
#=GS G3WP69_SARHA/236-300      AC G3WP69.1
#=GS F6ZDS7_MACMU/11-70        AC F6ZDS7.1
#=GS C1EGI3_MICSR/166-230      AC C1EGI3.1
#=GS H9L3K3_CHICK/130-194      AC H9L3K3.2
#=GS M7BJE1_CHEMY/258-320      AC M7BJE1.1
#=GS G3WP69_SARHA/127-193      AC G3WP69.1
#=GS W4XXD3_STRPU/3-68         AC W4XXD3.1
#=GS F1MUM9_BOVIN/132-197      AC F1MUM9.2
#=GS G5BDD4_HETGA/1-64         AC G5BDD4.1
#=GS I3MX49_SPETR/90-148       AC I3MX49.1
#=GS F1QQL0_DANRE/411-476      AC F1QQL0.1
#=GS W5LAV0_ASTMX/243-309      AC W5LAV0.1
#=GS H0YCK3_HUMAN/290-354      AC H0YCK3.1
#=GS G1M218_AILME/9-65         AC G1M218.1
#=GS H0WSD7_OTOGA/118-184      AC H0WSD7.1
#=GS I3NBG7_SPETR/12-70        AC I3NBG7.1
#=GS H0VCM8_CAVPO/11-68        AC H0VCM8.1
#=GS M4A7Z3_XIPMA/402-467      AC M4A7Z3.1
#=GS V8NFN1_OPHHA/224-277      AC V8NFN1.1
#=GS F1RAK5_DANRE/411-476      AC F1RAK5.1
#=GS H2P2E0_PONAB/11-70        AC H2P2E0.1
#=GS H3B681_LATCH/152-216      AC H3B681.1
#=GS H0WSD7_OTOGA/229-293      AC H0WSD7.1
#=GS F7HLJ8_CALJA/295-359      AC F7HLJ8.1
#=GS G1PVX2_MYOLU/10-67        AC G1PVX2.1
#=GS G1RL52_NOMLE/237-303      AC G1RL52.2
#=GS M4A7Z3_XIPMA/248-312      AC M4A7Z3.1
#=GS U3IQ81_ANAPL/127-191      AC U3IQ81.1
#=GS H9GRT6_ANOCA/125-191      AC H9GRT6.1
#=GS F7GMY9_MACMU/1-64         AC F7GMY9.1
#=GS E3_VAR67/7-72             AC P33863.1
#=GS G3TV03_LOXAF/254-318      AC G3TV03.1
#=GS H2N5K5_PONAB/295-359      AC H2N5K5.1
#=GS F1RGM8_PIG/133-195        AC F1RGM8.2
#=GS F1RAK5_DANRE/253-319      AC F1RAK5.1
#=GS G3V8T3_RAT/137-203        AC G3V8T3.1
#=GS DSRAD_HUMAN/135-201       AC P55265.4
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRR B; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 2ACJ C; 140-201;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F22 B; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 2L54 A; 140-68;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRR D; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRR A; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 2ACJ D; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 1QBJ C; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F23 B; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 2GXB B; 140-201;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F22 A; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 2ACJ A; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F21 C; 140-197;
#=GS DSRAD_HUMAN/135-201       DR PDB; 2GXB A; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F23 C; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 1QGP A; 140-200;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F21 B; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRQ B; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F23 A; 140-198;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F21 A; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3F22 C; 140-199;
#=GS DSRAD_HUMAN/135-201       DR PDB; 1QBJ B; 295-359;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRQ A; 295-359;
#=GS DSRAD_HUMAN/135-201       DR PDB; 1QBJ A; 295-359;
#=GS DSRAD_HUMAN/135-201       DR PDB; 2ACJ B; 295-359;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRQ D; 295-359;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRR C; 295-359;
#=GS DSRAD_HUMAN/135-201       DR PDB; 3IRQ C; 295-359;
#=GS L5K1E9_PTEAL/9-61         AC L5K1E9.1
#=GS G1PXF5_MYOLU/244-308      AC G1PXF5.1
#=GS A2APF7_MOUSE/87-144       AC A2APF7.1
#=GS G1R5Y9_NOMLE/11-69        AC G1R5Y9.1
F1QUI9_DANRE/6-71                    ..................a-ENEIEMRICDY.LRRHG-RSTVQDIFKELKLE.-.-.KSTVNRHLYSLQASKQ.VFKtvE..DN.K.RPVWNLVE--sm.............
H9L3K3_CHICK/28-93                   .................ag--QSLEQEILSI.LGQLQVGETRTVHDLARKLK.T.Q.RKEVNRVLYKLLKEGK.LHR..I..VG.T.PPLWRIA---np.............
ZBP1_RAT/11-69                       .................gd---NLEQKILQV.LSDAG--SPVQIDQLLKKLQ.V.P.KKILNQVLYRLKKEGR.VSS..P..--.-.----------apatwslg.......
G7NUJ1_MACFA/337-401                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
F6TP72_HORSE/239-303                 ...................DMAEIKEKICDY.LFNVS-NSSALNLAKNIGLT.K.-.ARDVNAVLIDLEMQGD.VYR..Q..GT.T.PPIWYLTDK-k..............
A0A096N395_PAPAN/433-497             ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
U3JET5_FICAL/118-182                 ...................DMAETKEKICNY.LFSVV-ETTALNLAKNIGLS.R.-.AKDVNAFLSALEKLGD.VHK..Q..NA.T.PPRWSLTNR-k..............
U3IQ81_ANAPL/26-92                   .................ag--QNHEQEILNI.FRQLGVGKTCTVYDLARKLK.T.Q.KKEVNRILYKLLREGK.LHK..G..EE.T.PPLWRIA---sps............
G3V8T3_RAT/245-309                   ...................DMAEIKEKICDY.LFNVS-KSSALNLAKNIGLA.K.-.ARDVNAVLIDLERQGD.VYR..E..GA.T.PPIWYLTDK-k..............
F7HS73_CALJA/295-359                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLS.K.-.ARDINAVLIDLERQGD.VSR..Q..GT.T.PPMWHLTDK-k..............
W5LAV0_ASTMX/389-454                 .................ea--KDNKERIMQY.LYEAG-KASALLIAKNLGFR.N.-.AKQVNPMLYAMEKQGD.LSR..M..SGvT.PPSWELS---ahr............
H3C5Q5_TETNG/188-250                 ..........diqeqvhga---------LLA.LKPSD-RVPAKWLAKQLHLP.-.-.KTIVNRALYSLERAQK.AFK..Q..GL.S.PPLWN-----acre...........
L9KHQ0_TUPCH/182-246                 ...................DMAEVKEKICNH.LFRVY-NSSALNLAKNIGFA.K.-.ARDVNAVLIDLERQGE.VYR..Q..GT.T.PPIWFLTDK-k..............
H2M250_ORYLA/284-348                 ...................MMADQKEKVLKY.LFELG-QTTALVLAKKLGLR.S.-.AKQINPTIYDLEKQGD.VIK..N..DT.I.PYKWELSP--hr.............
H2R1Y2_PANTR/178-244                 ...................IYQDQEQRILKF.LEELGEGKATTAHDLSGKLG.T.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
L5M6P1_MYODS/203-258                 .................yl-----EQRILQV.LKGAG--TPVKAAQLEKECQ.V.P.RKDINRALYRMRDKLQ.VDR..D..D-.-.----------sakwrl.........
DSRAD_MOUSE/248-312                  ...................DMAEIKEKICDY.LFNVS-NSSALNLAKNIGLT.K.-.ARDVTSVLIDLERQGD.VYR..Q..GA.T.PPIWYLTDK-k..............
G3SA86_GORGO/121-185                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
W4XPH4_STRPU/237-297                 ...........mdhrllva------------.LSEKVESIHSNDLAKQLGYR.T.-.KKEINPTLFSMQKKGL.VRK..V..CE.S.PPMWVITP--y..............
F7IKG8_CALJA/11-71                   ...............eghl-----EQRILKV.LMEAG--SPVKLSQLVKECQ.V.P.KKELNQVLYRMKTELK.V--..S..LT.A.PATWR-----lgga...........
F6XT26_CANFA/9-69                    ...................DERDLEQRILQA.LRDAG--SPIKSIQLVKECQ.V.P.KKKLNQVLYRLMKESK.VSQ..E..G-.-.PA--------twalgt.........
A0A091D3X5_FUKDA/251-317             ...................ISQDQEQRILAV.LEELGEQSATTARDLGRKLR.V.P.KKEVNHFLYSLAKKGK.LRR..G..AG.T.PPLWSIAA--sv.............
H9GRT6_ANOCA/228-292                 ..................a-MAEVKEKICDF.LFGVT-DSTAHNLARNVGLS.K.-.ARDVNATLVALEKLGE.VRK..E..NA.N.PPKWSLTDN-k..............
I3MMD8_SPETR/219-282                 ...................DMAEIKEKICDY.LFNVT-NCSALSLAKNIGFT.R.-.ARDVNAVLCDMEKQGD.VYR..Q..GA.I.P-TWYLTDK-k..............
M7AU33_CHEMY/1-64                    ...................-MAEVKEKICNY.LFNVT-DSTAYNLAKNIGFS.K.-.AKDVNATLSALEKLGE.VHK..E..NT.T.PPKWSLTDK-k..............
G1RL51_NOMLE/178-244                 ...................INQDQEQRILKF.LEELGEGKATTAHDLSGKLG.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKITVT-t..............
W4XXD3_STRPU/365-429                 ................spd----MEIKVLCA.LSNQQ-TQGTVEIVHNVGLN.RgK.AKDVNPSLYGLAKRGN.ITK..V..TD.S.PPTWHINE--k..............
G1SVD5_RABIT/110-176                 ...................INQDQEQRILGL.LEELREGEAVSAKYLAGKLR.V.P.KKGVNQALYSLAKRGK.LRQ..K..EG.N.PPLWSLAVS-v..............
H3C5Q5_TETNG/319-384                 ..................k-MPDQKELVLNH.LLNAG-ETTALCIAKNLGLK.T.-.AKQVNPTLYSLEKQGD.VIK..H..GEvN.PPTWELATH-r..............
M3VWG8_FELCA/241-305                 ...................DMAEIKEKICSY.LFNVC-NASALNLAKNIGLS.K.-.ARDVSAVLIDLERQGD.VCR..Q..GT.T.PPVWYLTDR-k..............
L5JUV0_PTEAL/135-199                 ...................DMAEIKERICEY.LFHAF-SSSALNLAKNIGLT.K.-.ARDVSAVLIDLERQGD.VYR..Q..GT.T.PPIWYLTDK-k..............
Q8V3R2_SWPV1/8-70                    edvyslvkqevdslpvgnf------------.---------ITAVEISKKIE.K.E.KSSINRQLYALYQQGY.IDM..V..PA.C.PPKW------ykrn...........
H9H124_MELGA/119-183                 ..................t-MAETKDKICNF.LFSVA-DTTAINLARNIGFS.R.-.AKDVNSFLSALEKLGD.VRK..Q..NS.S.PPRWSLTSR-k..............
H0Z0Z8_TAEGU/108-172                 ..................e-MAETKEKICNY.LFSVV-ETTALNLAKNIGFS.R.-.AKDVNAFLSALEKLGD.VHK..Q..NA.T.PPRWSLTNR-k..............
G3HBY8_CRIGR/138-203                 ...................ISQNPQQKILGR.LEELGEGKATSAQVLARELR.V.P.KKEINRILYSLERKGK.LHR..R..GG.S.PPLWSLAP--p..............
F6QDP5_MONDO/129-194                 ...................ISRDQEQSILKL.LGELGEGQSATVYDLARRLG.V.Q.KKEVNRVLYHLLKQGK.LQR..E..EA.T.PPNWRITPS-...............
G7PFS7_MACFA/11-69                   ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMLKELK.VS-..-..LT.A.PATW------rlg............
M3Y6Y0_MUSPF/270-334                 ...................DMAEIREKVCDF.LFNVC-GASALNVAKNIGLS.R.-.ARDVNAVLVDLERQGD.VYR..L..GA.T.PPVWHLSDK-k..............
H0XBP7_OTOGA/11-71                   .................gd---DLEQKILQV.LRDAS--SPVKTVQLVKECQ.V.P.KKELNRVLYQMKKELK.VSL..E..--.S.PTTWSL----arg............
G3TV03_LOXAF/132-198                 ...................ISQNQEERILKL.LEELGEGQTTTAYDLARKLG.V.P.KKEINRVLYSLAKEGK.LHQ..E..AG.K.PPLWRIAVS-v..............
F6ZDR2_MACMU/11-69                   ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMLKELK.VS-..-..LT.A.PATW------rlg............
H2TCA3_TAKRU/249-314                 ..................t-MSDQKELVLHY.LFNSG-ETTALCIAKNLGLK.T.-.TKQINPTLYTLEKQGD.VIK..H..SGvT.PATWELAT--hr.............
H2R1Y2_PANTR/338-402                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
G3PDZ1_GASAC/297-362                 ..................t-MAEQKELVLQY.LRTSK-GATALLMAKNLGLR.S.-.AKHINPTLYSLEKQGE.IVK.nS..AA.N.PPTWELS---ahr............
L5JUV0_PTEAL/24-90                   ...................ISQEQEQRVLEL.LQELGAGKAITAHDLARRLQ.A.S.KKEVNSVLYSLARKGR.LLR..E..VG.T.PPLWRAAV--sa.............
DSRAD_HUMAN/295-359                  ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
#=GR DSRAD_HUMAN/295-359       SS    ...................EHHHHHHHH-GG.HHHHH-HHHHHHHTTSEEEE.S.-.EEEE-HHHXXXXXXXX.XXX..X..XX.X.XXXXXXXXX-X..............
F7GLF8_MACMU/134-200                 ...................INQDQEQRILKF.LEELGEGKATTAHDLSWKLG.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
F6TP72_HORSE/132-195                 ..................i-GQDQEQRILEE.LEE---GNLTTARALAVKLE.V.P.KKEINRALYSLAKKGK.LHQ..E..AG.T.PPLWRLAVS-g..............
M3Y6Y0_MUSPF/160-227                 .................ir--QGQDERVSELvLQQLGEATAATAHDLAGRLG.V.P.KKEVNRVLYSLEKKGQ.LCR..E..AG.T.PPLWRVAA--qa.............
H2N5K5_PONAB/135-201                 ...................INQDQEQKILKF.LEELGEGKATTAHDLSGKLG.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKISVS-t..............
A0A093BQH7_CHAPE/17-83               ..................a-EQDCEQEVLTI.FRRLGEGETRTVHDLVRQLN.T.R.KKEVNRVLYKLCQEGK.LHR..E..GG.T.PPLWSLA---spk............
H2M250_ORYLA/155-215                 ................viq------EQVHKA.LK-ADEAIPAKVLAKKLHLP.-.-.KKVVNQALYSLEPLKK.ASK..Q..GL.L.PPEWTLY---ren............
G3TIV1_LOXAF/107-173                 ...................ISQNQEERILKL.LEELGEGQTTTAYDLARKLG.V.P.KKEINRVLYSLAKEGK.LHQ..E..AG.K.PPLWRIAVS-v..............
G3HBY8_CRIGR/249-313                 ...................DMAEIKEKICDY.LFNVS-NSSALNLAKNVGLT.K.-.ARDVNAVLIDLERQGD.VYR..Q..GA.T.PPIWCLTDK-k..............
K1PWV0_CRAGI/29-93                   ...............vdqr----HVQSILEY.LKSKR--MPVKTIDIAKGLGfK.S.SSEINPVLYRMEKNGI.VRR..C..EG.E.KMMWTL----nsd............
F6ZMB0_XENTR/82-148                  ..............srdpv-----ESRLLDY.IRGLSDGQTFTAKELAWRFK.V.A.KKCINHFLYRFEGKGL.LCK..S..LG.T.PPVWRVSS--at.............
G3TIV1_LOXAF/218-282                 ...................DMAEIKEKICDH.LFNVS-NSSALNLAKNIGLT.K.-.ARDVNAMLIDLERQGD.VYR..Q..GA.T.PPIWYLTDK-k..............
U3JET5_FICAL/17-83                   .................ag--QDYEQEILTV.LRQLGEGRTCTAIDLARKLK.A.Q.KKEVNRVLYKLLGEGK.LHK..G..GE.T.RPLWRIA---sps............
F7HLJ8_CALJA/135-201                 ...................INQDQEQRILKL.LKELGEGKATTVHDLSGKLR.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.I.PPLWKISA--sa.............
F1PQB2_CANFA/102-168                 ...................ISQGEEERVLEL.LRGLGEGKAATAHDLAAKFR.V.P.KREINRVLYSLAKKGQ.LHR..E..AG.T.PPLWRIATQ-a..............
G3QW58_GORGO/178-244                 ...................IYQDQEQRILKF.LEELGEGKATTAHDLSGKLG.T.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
V8NFN1_OPHHA/349-412                 ...................DMAEVKEKICSF.LFGVA-DSTALNLAKNIGLT.R.-.ARDVSATLLALEKLGE.VHK..E..NA.S.PPRWX-----alpa...........
H0V5I6_CAVPO/50-114                  ...................DMAEIKEKICNY.LFNVS-NSSALNLAKNIGLT.K.-.ARDVNAVLMDLERQGD.VYR..Q..GA.T.PPIWYLTDK-k..............
W4XPH4_STRPU/399-464                 ................asp---DMEIKVLCA.LSNQQ-TQGTVEIVHNVGLN.RgK.AKDVNPSLYGLAKRGN.ITK..V..TD.S.PPTWHINE--k..............
E3_VACCW/7-72                        ...................DERSNAEIVCEA.IKTIG-IEGATAAQLTRQLN.M.E.KREVNKALYDLQRSAM.VYS..S..DD.I.PPRWFMTTE-a..............
G3R5Y8_GORGO/11-70                   ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KKELNQVLYRMKKELK.VS-..-..LT.A.PATW------rlgg...........
F7GLF8_MACMU/293-357                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
H2TCA4_TAKRU/239-301                 .................di--QEQVHRALVA.LKPSD-SIAARWLAKK--LH.L.P.KKIVNKALYSLERTQK.ASK..Q..GL.S.PPLWT-----tyre...........
A0A087Y9I9_POEFO/404-469             ...................IMANSKEQVLQF.LLDVG-EATALVIAKNLGLK.N.-.AKQINPTLYALEKQGE.VNR..D.sDV.T.PPKWMLS---ahr............
Q08FV9_DPV83/12-76                   .................dm---EITKLVNDI.ITNLPLGRHITALEIARRLN.I.E.KSHINRQLYKLYHEGS.LNV..L..PT.N.PPRWF-----kkpc...........
A0A087Y9I9_POEFO/249-314             ................tpd----IQEQVHRA.LAALKSGERISAKVLARRIH.L.P.KKTVNKALYSLERLHR.AYK..Q..EV.L.PPLWSLY---rae............
E7F3L7_DANRE/253-319                 ................ltp---EIHQQVCAF.LTSLRPAETIQAKVLGKKLG.L.P.KKIVNKVLYDLLKSNQ.VVK..Q..GE.T.PPLWRLCE--es.............
T1J5P4_STRMM/254-316                 .................ll-----AQRLLAR.LAELDRPIEVDQLALDVGLR.S.-.KKDINPVLYSLLRQGR.VQK..M..QD.V.PPMWAIANE-d..............
I1GJ01_AMPQE/274-339                 ................rtd---ESRSLILQY.LSTCSEEKKAASIAYDLGMS.-.-.RHDVNAILYALESEGL.VRC..F..KG.IgPPVWIMKQ--tn.............
G3SA86_GORGO/10-76                   ...................IYQDQEQRILKF.LEELGEGKATTAHDLSGKLG.T.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
A0A0D9S5D2_CHLSB/1-64                ...................-MAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
H3DLT9_TETNG/1-40                    ...................------------.--------------LAKQLH.L.P.KTIVNRALYSLERAQK.AFK..Q..GL.S.PPLWN-----acre...........
A0A091D3X5_FUKDA/362-426             ...................DMAEIKEKICAY.LFNVS-NSSALNLAKNIGLT.K.-.ARDVNTVLTDLERQGD.VYR..Q..GA.T.PGIWHLTDK-k..............
Q3A9H9_CARHZ/1-49                    ...................-MEELKQKIIDY.LKTVD-KAKNKEVAQALGVS.-.-.KGEVDKAVTELAKEDK.I--..-..--.-.----------ef.............
G3V6S4_RAT/87-148                    ................aqp---SLEERILRF.LETKG-PQRALHIAKALGMT.T.-.AKEVNPILYSMRNKHL.LTV..S..DT.Q.----------mwtiyrs........
Q5NE14_DANRE/6-71                    ..................a-ENEIEMRICDY.LRRHG-RSTVQDIFKELKLE.-.-.KSTVNRHLYSLQASKQ.VFKtvE..DN.K.RPVWNLVE--sm.............
#=GR Q5NE14_DANRE/6-71         SS    ..................B-HHHHHHHHT--.HHHHH-HHHHHHTTSEEEE-.-.-.-EEEE--XXXXXXXXX.XXXXXX..XX.X.XXXXXXXX--XX.............
E9QIW2_DANRE/253-319                 ................ltp---EIHQQVCAF.LTSLRPAETIQAKVLGKKLG.L.P.KKIVNKVLYDLLKSNQ.VVK..Q..GE.T.PPLWRLCE--es.............
M3Y5L5_MUSPF/9-69                    ...................DETDLEQRILQV.LRDVG--SPMKSSQLAKECQ.V.P.KKNVNQVLYQMLKESK.VSQ..E..--.R.PAMW------glgq...........
H2TCA3_TAKRU/141-204                 ...........dsleeqvh-------RALVA.LKPSD---SIAARWLAKKLH.L.P.KKIVNKALYSLERTQK.ASK..Q..GL.S.PPLWT-----tyre...........
M3VWG8_FELCA/130-196                 ...................ISQGQERTVLEL.LRELGEGKAATAHDLAGKLG.V.P.KKEVNRVLYSLAKKGK.LHQ..E..AG.T.PPLWRIAPA-v..............
H0YCK3_HUMAN/130-196                 ...................IYQDQEQRILKF.LEELGEGKATTAHDLSGKLG.T.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
I3JGJ6_ORENI/242-307                 ................ltt---EIQGEVHEA.LGALKPSESISAKVLARKLH.L.P.KKVVNKALYSLEHLQK.ASK..Q..GL.T.PPEWTLY---re.............
A0A096N395_PAPAN/178-244             ...................INQDQEQRILKF.LEELGEGKATTAHDLSWKLG.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
L9KHQ0_TUPCH/45-110                  ...................ISQNQEQRILEL.LEDLGAGQTITAHDLARKLG.A.P.KKDVNRVLYSLAKEGK.LHK..E..AG.T.PPLWRI----lis............
W5LAU8_ASTMX/243-308                 .................lt--TDIQKQVLSS.LASLGPGETIQAKVLAKKLR.L.P.KKIVNQALYALSSLHQ.AVK..Q..GD.T.PPLWRLR---re.............
I3M9F2_SPETR/12-70                   ................ghl-----EQKILQV.LGDAS--SPLKSYQLVKECQ.A.P.KKELNSVLYRMAKEGT.VSQ..-..--.-.----------vapatwrlgt.....
F6WQ52_HORSE/106-164                 ...............errl-----QEMIYNF.LKADG-PHKALTITKALGLE.T.-.KKEVNHNLYDMERKHL.LHH..D..--.-.----------tnldvwav.......
G1RL51_NOMLE/289-353                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
A2APF7_MOUSE/11-70                   .................gd---NLEQKILQV.LSD--DGGPVKIGQLVKKCQ.V.P.KKTLNQVLYRLKKEDR.VSS..P..--.E.PATW------sigg...........
H2TCA4_TAKRU/369-434                 ..................t-MSDQKELVLHY.LFNSG-ETTALCIAKNLGLK.T.-.TKQINPTLYTLEKQGD.VIK..H..SGvT.PATWELAT--hr.............
W5NY89_SHEEP/249-313                 ...................DMAEIKEKICDH.LFNVS-SSSALNLAKNIGLT.K.-.ARDVNAVLIDLERQGD.VYR..Q..GT.T.PPIWYLTDK-k..............
W4XPH4_STRPU/38-103                  ................snt---ELANGILNK.LKESNGSMETLELARSLGRR.S.-.RKDVNPTLYRMQKNGL.ILK..V..SA.S.PPKWGLKN--ev.............
W5NY89_SHEEP/138-203                 ...................ISQDQEQRTLKL.LDELGDGKATTVRDLARKLQ.A.P.KKDINRVLYSLAEKGK.LHQ..E..VG.S.PPLWRAT---vp.............
M3VUQ8_FELCA/33-84                   ..................e--TDLEQRILRV.LRDAG--SPVKSVQLAKECQ.V.P.KKKLNQVLYRMEKESK.VS-..-..--.-.----------lag............
G3PDZ1_GASAC/161-225                 ................tpd----IQDQVHRA.LAALKPNESICARFLAKKLH.L.P.KKVVNRALYLLERSQK.ASK..Q..GL.V.PPEWSLC---re.............
G3HBK7_CRIGR/41-97                   .................la-----DERIIRF.LETSG-PHRALHIAKALGMK.T.-.AKEVNPHLYAMRNRH-.---..-..--.-.----------llsydgntwmiyd..
G1RL52_NOMLE/348-412                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
M3XGS0_LATCH/115-178                 .................gd----NQEDILNI.LKGLEQGRTLSAFQIAKQLG.I.K.KKVVNHFLYKLLKQGQ.VCR..E..GD.R.PPLWNIVV--q..............
W4XXD3_STRPU/202-262                 .............mdhrll----------MA.LSEKVESIHSNDLAKQLGYR.T.-.KKEINPTLFSMQKKGL.VRK..V..CE.S.PPMWVITP--y..............
I3M9F2_SPETR/105-164                 .................ls---ELEEKILGF.LKASG-PCKALHIAQALEMR.T.-.AKDVNPTLYKMKSKR-.---..-..--.-.----------lldqdqklqvwrvs.
I3JGJ6_ORENI/391-456                 ..................l-MAEQKEQIFKY.LLQSR-EATALNIAKNIGLK.T.-.AKQVNSTLYALEKQGE.VVR..N..VEvN.PPTWELST--hr.............
W5Q7K5_SHEEP/33-94                   .................dt---DLEQRILEV.LRDAG--SPVKTTQLLKKLQ.V.P.KKKLNQLLHKMKQESK.---..-..--.-.----------gvmlagpamwclgds
T1J5P4_STRMM/7-68                    ........lrneilayfhq------------.---NP-SRPIRTVELTRKLR.R.E.KRTVNYHLYALQRQGA.IRK..V..VV.S.PPTWCLEA--sn.............
H2QKN2_PANTR/11-69                   ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMKKEFK.VS-..-..LT.A.PATW------rlg............
G5AUM6_HETGA/105-164                 ...............vagq----LEQKILQA.LRKAGSAVHTRLLVKECQVL.-.-.KQELNRVLYRMQKESK.VS-..-..--.-.----------lvapatwhlg.....
G1LYN3_AILME/243-307                 ...................DMAEVKEKVCDY.LFNVC-GASALNVAKNIGLA.R.-.ARDVNAVLMDLERQGD.VYR..Q..GT.T.PPVWYLADK-k..............
DSRAD_RAT/245-309                    ...................DMAEIKEKICDY.LFNVS-KSSALNLAKNIGLA.K.-.ARDVNAVLIDLERQGD.VYR..E..GA.T.PPIWYLTDK-k..............
G7NUJ1_MACFA/178-244                 ...................INQDQEQRILKF.LEELGEGKATTAHDLSWKLG.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
I3MMD8_SPETR/108-173                 ...................ISQGHEERILEF.LKELGEGKDTTARELARKLR.V.P.KREVNQALYSLAKKGQ.LHR..K..QG.T.PPLWSA----aas............
ZBP1_MOUSE/87-144                    ...............qpsl-----DERILRF.LEANG-PHRALHIAKALGMT.T.-.AKEVNPLLYSMRNKHL.L--..-..--.-.----------sydgqtwkiy.....
F1MUM9_BOVIN/243-307                 ...................DMAEIKEKICDH.LFNVS-SSSALNLAKNIGLT.K.-.ARDVNAVLIDLERQGD.VYR..Q..GT.T.PPIWYLTDK-k..............
DSRAD_MOUSE/137-203                  ...................ISQSPEQKVLNR.LEELGEGKATTAHVLARELR.I.P.KRDINRILYSLEKKGK.LHR..G..RG.K.PPLWSLVP--ls.............
L5M6P1_MYODS/275-332                 .................sh---ELQEQILRL.LETRG-PQRALSIAKSLGMK.T.-.SKDVNRYLYAMQEEH-.---..-..--.-.----------lldldknsktwk...
F1RGM8_PIG/241-305                   ...................DMAEIKEKICDY.LFNVS-NSSALNLAKNIGLT.K.-.ARDVNAVLIDLERQGD.VCR..Q..GT.T.PPMWYLTDK-k..............
Q6TUX8_YMTV5/15-74                   ..........lvknevmml------------.--NVD--EYTTSIDISNKLK.I.N.KKKINKQLYKLQKEGV.LKM..V..PS.N.PPKWFKNC--nc.............
H9H124_MELGA/17-82                   .................ag--QSLEQEILSI.LGQLREGETCTVHDLVRKLK.T.Q.RKEVNRVLYKLLGEGK.LHR..I..AG.I.PPLWRIA---np.............
F7HS73_CALJA/133-199                 ...................INQDQEQRILKL.LKELGEGKATTVHDLSGKLR.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.I.PPLWKISA--sa.............
G1PXF5_MYOLU/133-198                 ..................i-GQDQEQRVLEL.LQELGEGKATTAHDLARKLQ.A.P.KKEINHILYCLEGRGV.LHR..E..AG.T.PPLWRIA---ap.............
G1SVD5_RABIT/227-291                 ...................DMAEIKEKICNY.LFKVS-NSSALNVAKNIGFS.K.-.ARDVNAVLIDLERQGD.VYR..Q..GA.T.PPIWYLTDK-k..............
F1QXK7_DANRE/6-71                    ..................a-ENEIEMRICDY.LRRHG-RSTVQDIFKELKLE.-.-.KSTVNRHLYSLQASKQ.VFKtvE..DN.K.RPVWNLVE--sm.............
E9QIW2_DANRE/411-476                 ...................DSKDSKEKILQY.LYEAG-TGNALVIAKNLGLR.S.-.AKQVNPTLYALEKQGD.VNR..N..TEvN.PPTWELS---ahr............
M3XGS0_LATCH/232-296                 ..................n-MADLKEQICEY.LFGVK-NSTALSIAKNVGLK.R.-.AKDVNNVLYALEKQGD.ISK..E..NT.F.PPHWSLTEK-k..............
DSRAD_RAT/137-203                    ...................ISQNPEQKVLNR.LEELGEGKATTAYALARELR.T.P.KKDINRILYSLERKGK.LHR..G..VG.K.PPLWSLVP--ls.............
A0A0D2WVC4_CAPO3/7-63                ...............leqt--------ALDFvLKNSG--VDALAVAKQAKLV.T.-.QKDINPTLYALEKAGQiVRR..E..TG.S.RPLW------y..............
H0Z0Z8_TAEGU/7-72                    .................ag--QDYEREILTV.LRQLGEGRTCTANDLARKLK.T.T.KKEVNRVLYKLLKEGK.LHK..E..GE.T.PPLWRI----psp............
E7F3L7_DANRE/411-476                 ...................DSKDSKEKILQY.LYEAG-TGNALVIAKNLGLR.S.-.AKQVNPTLYALEKQGD.VNR..N..TEvN.PPTWELS---ahr............
F1PQB2_CANFA/211-275                 ...................DMAELKEKVCDY.LFNVC-SSSALNLAKNIGLT.R.-.ARDVNAVLIDLERQGD.VYR..Q..GT.T.PPIWYLTDK-k..............
W5LAU8_ASTMX/412-477                 .................ea--KDNKERIMQY.LYEAG-KASALLIAKNLGFR.N.-.AKQVNPMLYAMEKQGD.LSR..M..SGvT.PPSWELS---ahr............
I1EJI4_AMPQE/275-340                 .................qt--NESRSLILQY.LSTCSEEKKAASIAYDLGMS.-.-.RHDVNAILYALESEGL.VRC..F..KG.IgPPVWIMKQ--tn.............
G3V6S4_RAT/11-69                     .................gd---NLEQKILQV.LSDAG--SPVQIDQLLKKLQ.V.P.KKILNQVLYRLKKEGR.VSS..P..--.-.----------apatwslg.......
A0A093BQH7_CHAPE/115-179             ...................IMAETKDKICNY.LFSVA-ETTALNLAKNIGFS.R.-.AKDVNAFLSALEKLGD.VHK..E..NT.T.PPLWSLTDR-k..............
ZBP1_HUMAN/11-69                     ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMKKELK.VS-..-..LT.S.PATW------clg............
#=GR ZBP1_HUMAN/11-69          SS    ...............TS-E-----HHHHTS-.HHHHH--HHHHHTTSEEEEE.T.E.ESXXXXXXXXXXXXXX.XX-..-..XX.X.XXXX------XXX............
Q6TVV0_ORFSA/1-65                    ...................MACECASLILEL.LRKSDDKLPAKQIAKELGIS.-.-.KHEANRQLYRMLELDD.VCC..E..DG.N.PPRWFVECA-p..............
F1QQL0_DANRE/253-319                 ................ltp---EIHQQVCAF.LTSLRPAETIQAKVLGKKLG.L.P.KKIVNKVLYDLLKSNQ.VVK..Q..GE.T.PPLWRLCE--es.............
F6WQ52_HORSE/9-61                    .................tk--TDLEQKILQV.LRDAG--SPVKAIKLAKECG.V.S.KKTLNRVLYRMKTELK.V--..-..--.-.----------dleg...........
F6DQV5_DESRL/1-49                    ...................-MEEIKEKILDY.LTAVS-KEKPRVVAEKIGVK.-.-.KKEVDKAVAELAKEGK.I--..-..--.-.----------ey.............
ZBP1_MOUSE/11-70                     .................gd---NLEQKILQV.LSD--DGGPVKIGQLVKKCQ.V.P.KKTLNQVLYRLKKEDR.VSS..P..--.E.PATW------sigg...........
#=GR ZBP1_MOUSE/11-70          SS    .................-E---HHHHHH-S-.HHH--HHHHHHHTTSEEEEE.T.E.E-XXXXXXXXXXXXXX.XXX..X..--.X.XXXX------XXXX...........
G1LYN3_AILME/132-198                 ...................ISQGQEERVLEL.LQELGEGKAATVHDLAGKLR.V.P.KKEVNRVLYSLEKKGQ.LHR..E..PG.T.PPLWTIAVQ-a..............
H3B681_LATCH/35-98                   .................gd----NQEDILNI.LKGLEQGRTLSAFQIAKQLG.I.K.KKVVNHFLYKLLKQGQ.VCR..E..GD.R.PPLWNIVV--q..............
I3MX49_SPETR/12-70                   ................ghl-----EQKILQV.LGDAS--SPLKSYQLVKECQ.A.P.KKELNSVLYRMAKEGT.VSQ..-..--.-.----------vapatwrlgt.....
I3NBG7_SPETR/82-142                  ................aqd---SHEEKILGF.LKASG-PCKALHIAQALEMR.T.-.AKDVNPTLYKMKSKR-.---..-..--.-.----------lldqdqklqvwrvs.
A0A096NNI5_PAPAN/11-69               ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMLKELK.VS-..-..LT.A.PATW------rlg............
H3DLT9_TETNG/109-174                 ..................k-MPDQKELVLNH.LLNAG-ETTALCIAKNLGLK.T.-.AKQVNPTLYSLEKQGD.VIK..H..GEvN.PPTWELATH-r..............
F6QDP5_MONDO/238-302                 ..................n-MADIKEKICAY.LFDVL-DSSALNLAKNIGLT.K.-.ARDINNLLLELERQGD.IRR..E..GF.T.SPKWSLTVK-k..............
G3QW58_GORGO/338-402                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
T1J5P4_STRMM/424-489                 .................td--QEMREMVLEQ.MGKSA-KKTVSALEMARAFS.L.PnKKAVNRALYYLKRQGL.VSK..V..SI.K.PALWSL----gnv............
T1J5P4_STRMM/148-211                 ................sld----VNNSILQM.LSTQG-AMGATELAKALGFH.S.-.KKDANPYLYELQLKGL.VKK..V..QD.T.PPLWEA----vqds...........
L9L955_TUPCH/101-158                 ...............eghl-----EQKILQV.LGDAG--CPVRIAQLVRQCQ.V.P.KKELNQVLYRMKGESK.I--..-..--.-.----------slaapatwcl.....
ZBP1_RAT/87-148                      ................aqp---SLEERILRF.LETKG-PQRALHIAKALGMT.T.-.AKEVNPILYSMRNKHL.LTV..S..DT.Q.----------mwtiyrs........
G3WP69_SARHA/236-300                 ..................n-MTEVKEKICAY.LYDVP-DSSALNLAKNIGLA.K.-.ARDVNTLLFDLERQGD.VRR..E..GF.A.PPKWSLTVK-k..............
F6ZDS7_MACMU/11-70                   ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMLKELK.VS-..-..LT.A.PATW------rlgg...........
C1EGI3_MICSR/166-230                 .................vp-----EDKLLAA.LTLKG-DDGATAKELAGFLK.M.G.KSEVNKALYRLQSSGR.VRS..DgaGG.G.APTWRV----gsss...........
H9L3K3_CHICK/130-194                 ..................t-MAETKDKICNF.LFSVA-DTTAINLARNIGFS.R.-.AKDVNSFLSALEKLGD.VRK..Q..NC.T.PPRWSLTSR-k..............
M7BJE1_CHEMY/258-320                 ..............taqlk----SEKKIYQF.LSENG-SCRALGIAKYMGMK.T.-.QKEVNADLYAMQKKHI.LSQ..K..ED.T.----------klwsvyg........
G3WP69_SARHA/127-193                 ...................INQDQEQRILEL.LGELREGQCTTVYDLAKKLG.V.Q.KKEVNRVLYHLLKQGK.LHR..E..EG.T.PPGWRIPTQ-s..............
W4XXD3_STRPU/3-68                    ................snt---ELANGILNK.LKESNGSMETLELARSLGRR.S.-.RKDVNPTLYRMQKNGL.ILK..V..SA.S.PPKWGLKN--ev.............
F1MUM9_BOVIN/132-197                 ...................ISQDQEQRTLEL.LDELGDGKATTARDLARKLQ.A.P.KKDINRVLYSLAEKGK.LHQ..E..AG.S.PPLWRAT---vp.............
G5BDD4_HETGA/1-64                    ...................-MAEIKEKICAH.LFNVS-NSSALNLAKNIGLT.K.-.ARDVNTVLIDLERQGD.VCR..Q..GA.T.PPMWHLTDK-k..............
I3MX49_SPETR/90-148                  ................sts-----REKILGF.LKASG-PCKALHIAQALEMR.T.-.AKDVNPTLYKMKSKR-.---..-..--.-.----------lldqdqklqvwrvs.
F1QQL0_DANRE/411-476                 ...................DSKDSKEKILQY.LYEAG-TGNALVIAKNLGLR.S.-.AKQVNPTLYALEKQGD.VNR..N..TEvN.PPTWELS---ahr............
W5LAV0_ASTMX/243-309                 .................lt--TDIQKQVLSS.LASLGPGETIQAKVLAKKLR.L.P.KKIVNQALYALSSLHQ.AVK..Q..GD.T.PPLWRLRR--ea.............
H0YCK3_HUMAN/290-354                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
G1M218_AILME/9-65                    ...................DERDLEQRVLQV.LRDAG--SPVKSLQLAKECQ.V.P.KKKLNQVLYRMRKESK.VSL..E..G-.-.----------qaiw...........
H0WSD7_OTOGA/118-184                 ...................INQDQEQRILKL.LEELREGKATTAHDLAGKLG.V.P.KKEVNRVLYSLANKGK.LYQ..E..AG.K.PPLWRVAVS-v..............
I3NBG7_SPETR/12-70                   ................ghl-----EQKILQV.LGDAS--SPLKSYQLVKECQ.A.P.KKELNSVLYRMAKEGT.VSQ..-..--.-.----------vapatwrlgt.....
H0VCM8_CAVPO/11-68                   ................gdq----LEQKILQA.LRKAG--SPMRTPLLVRECQ.V.P.KQQLNRVLYQMLKESK.VS-..-..--.-.----------lvapatwsl......
M4A7Z3_XIPMA/402-467                 ...................IMANCKERVLQF.LLDVG-EATALVIAKNLGLK.N.-.AKQINPTLYALAKQGE.VNR..D.sDV.T.PPKWMLS---ahr............
V8NFN1_OPHHA/224-277                 ...............tqgv-----ERHLLET.LRDLK--SGQTTCQLAHQLC.I.Q.KKVVNRHLYKLRHQGQ.LSR..S..ET.-.----------x..............
F1RAK5_DANRE/411-476                 ...................DSKDSKEKILQY.LYEAG-TGNALVIAKNLGLR.S.-.AKQVNPTLYALEKQGD.VNR..N..TEvN.PPTWELS---ahr............
H2P2E0_PONAB/11-70                   ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMKKELK.VS-..-..LT.A.PATW------rlgg...........
H3B681_LATCH/152-216                 ..................n-MADLKEQICEY.LFGVK-NSTALSIAKNVGLK.R.-.AKDVNNVLYALEKQGD.ISK..E..NT.F.PPHWSLTEK-k..............
H0WSD7_OTOGA/229-293                 ..................e-MAEIKERICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDVNAMLIDLERQGD.VYR..Q..GT.T.PPIWYLTDK-k..............
F7HLJ8_CALJA/295-359                 ...................DMAEIKEKICDY.LFNVS-DSSALNLAKNIGLS.K.-.ARDINAVLIDLERQGD.VSR..Q..GT.T.PPMWHLTDK-k..............
G1PVX2_MYOLU/10-67                   .................pd----LEQRILQA.LKGAG--TPVKAAQLEKECQ.V.P.RKDINRVLYRMKEKLK.VDR..D..DS.-.----------akwslr.........
G1RL52_NOMLE/237-303                 ...................INQDQEQRILKF.LEELGEGKATTAHDLSGKLG.A.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKITVT-t..............
M4A7Z3_XIPMA/248-312                 ................pdi--QEQVHRALAA.LK-SGERISARVLAKKIHLP.-.-.KKTVNKALYSLERSQR.AYK..Q..EV.L.PPLWSLY---rae............
U3IQ81_ANAPL/127-191                 ..................t-MAETKDKICNY.LFRVA-ETTALNLAKNIGFS.K.-.AKDVNAFLSALEKLGD.VHK..E..NS.N.PPRWSLTDR-k..............
H9GRT6_ANOCA/125-191                 ...............trqg----LEQSLLEA.LRRLAPQETETARRLATCLD.V.P.KKDVNHHLYKLHSWGL.VCK..V..GD.R.PPSWRLADS-a..............
F7GMY9_MACMU/1-64                    ...................-MAEIKEKICDY.LFNVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..Q..GT.T.PPIWHLTDK-k..............
E3_VAR67/7-72                        ...................DERSDAEIVCEA.IKNIG-LEGVTAVQLTRQLN.M.E.KREVNKALYDLQRSAM.VYS..S..DD.I.PPRWFMTTE-a..............
G3TV03_LOXAF/254-318                 ...................DMAEIKEKICDH.LFNVS-NSSALNLAKNIGLT.K.-.ARDVNAMLIDLERQGD.VYR..Q..GA.T.PPIWYLTDK-k..............
H2N5K5_PONAB/295-359                 ...................DMAEIKEKICDY.LFDVS-DSSALNLAKNIGLT.K.-.ARDINAVLIDMERQGD.VYR..P..WT.T.PPIWHLTDK-k..............
F1RGM8_PIG/133-195                   ...................ISQDQEQRVL--.-EELGEGKAATAHDLAWKLQ.T.P.KREINRILYSLAKKGK.LHR..E..AG.T.PPWWRIAV--p..............
F1RAK5_DANRE/253-319                 ................ltp---EIHQQVCAF.LTSLRPAETIQAKVLGKKLG.L.P.KKIVNKVLYDLLKSNQ.VVK..Q..GE.T.PPLWRLCE--es.............
G3V8T3_RAT/137-203                   ...................ISQNPEQKVLNR.LEELGEGKATTAYALARELR.T.P.KKDINRILYSLERKGK.LHR..G..VG.K.PPLWSLVP--ls.............
DSRAD_HUMAN/135-201                  ...................IYQDQEQRILKF.LEELGEGKATTAHDLSGKLG.T.P.KKEINRVLYSLAKKGK.LQK..E..AG.T.PPLWKIAVS-t..............
#=GR DSRAD_HUMAN/135-201       SS    ...................SEBEHHHHHHHH.S-HHHHHHHHHHHHHTTSEE.E.S.SEEEEE--SXXXXXXX.XXX..X..XX.X.XXXXXXXXX-X..............
L5K1E9_PTEAL/9-61                    ................snt---DLRQRILQV.LRDTG--SPVKAPQLQKKCG.V.P.RKRLNQVLYQMKTEQL.VVR..-..--.-.----------ld.............
G1PXF5_MYOLU/244-308                 ...................DMAEIKEDICNH.LFDVV-KSSALNLAKNIGLS.K.-.ARDVNAVLIDLERQGD.VYR..E..GT.T.PPIWYLTDK-k..............
A2APF7_MOUSE/87-144                  ...............qpsl-----DERILRF.LEANG-PHRALHIAKALGMT.T.-.AKEVNPLLYSMRNKHL.L--..-..--.-.----------sydgqtwkiy.....
G1R5Y9_NOMLE/11-69                   ...............eghl-----EQRILQV.LTEAG--SPVKLAQLVKECQ.A.P.KRELNQVLYRMKKQLK.VS-..-..LT.A.P---------atwclg.........
#=GC SS_cons                         ...............TS.ECHHHHHHHHTSH.HHHHHHHHHHHHTTSEEEEE.T.E.EEEEECHHSXXXXXXX.XXX..X..XX.X.XXXXXXXXX-X..............
#=GC seq_cons                        .....................t-.cp+Ilph.Ltpsu.spsshshshshtLp.t...pK-lNplLYsLc+pGc.lp+..p..ss.s.PPhWpls...p..............
//
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