KEGG   Pantholops hodgsonii (chiru): 102321231Help
Entry
102321231         CDS       T02909                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
phd  Pantholops hodgsonii (chiru)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:phd00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102321231 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102321231 (PIK3CA)
   04015 Rap1 signaling pathway
    102321231 (PIK3CA)
   04012 ErbB signaling pathway
    102321231 (PIK3CA)
   04370 VEGF signaling pathway
    102321231 (PIK3CA)
   04630 Jak-STAT signaling pathway
    102321231 (PIK3CA)
   04668 TNF signaling pathway
    102321231 (PIK3CA)
   04066 HIF-1 signaling pathway
    102321231 (PIK3CA)
   04068 FoxO signaling pathway
    102321231 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102321231 (PIK3CA)
   04024 cAMP signaling pathway
    102321231 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    102321231 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102321231 (PIK3CA)
   04152 AMPK signaling pathway
    102321231 (PIK3CA)
   04150 mTOR signaling pathway
    102321231 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    102321231 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    102321231 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    102321231 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    102321231 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102321231 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102321231 (PIK3CA)
   04660 T cell receptor signaling pathway
    102321231 (PIK3CA)
   04662 B cell receptor signaling pathway
    102321231 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102321231 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102321231 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102321231 (PIK3CA)
   04062 Chemokine signaling pathway
    102321231 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    102321231 (PIK3CA)
   04915 Estrogen signaling pathway
    102321231 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102321231 (PIK3CA)
   04917 Prolactin signaling pathway
    102321231 (PIK3CA)
   04921 Oxytocin signaling pathway
    102321231 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102321231 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102321231 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    102321231 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102321231 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    102321231 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102321231 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102321231 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    102321231 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    102321231 (PIK3CA)
   05205 Proteoglycans in cancer
    102321231 (PIK3CA)
   05203 Viral carcinogenesis
    102321231 (PIK3CA)
   05210 Colorectal cancer
    102321231 (PIK3CA)
   05212 Pancreatic cancer
    102321231 (PIK3CA)
   05214 Glioma
    102321231 (PIK3CA)
   05221 Acute myeloid leukemia
    102321231 (PIK3CA)
   05220 Chronic myeloid leukemia
    102321231 (PIK3CA)
   05218 Melanoma
    102321231 (PIK3CA)
   05211 Renal cell carcinoma
    102321231 (PIK3CA)
   05215 Prostate cancer
    102321231 (PIK3CA)
   05213 Endometrial cancer
    102321231 (PIK3CA)
   05222 Small cell lung cancer
    102321231 (PIK3CA)
   05223 Non-small cell lung cancer
    102321231 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102321231 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102321231 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    102321231 (PIK3CA)
   05166 HTLV-I infection
    102321231 (PIK3CA)
   05162 Measles
    102321231 (PIK3CA)
   05164 Influenza A
    102321231 (PIK3CA)
   05161 Hepatitis B
    102321231 (PIK3CA)
   05160 Hepatitis C
    102321231 (PIK3CA)
   05169 Epstein-Barr virus infection
    102321231 (PIK3CA)
   05146 Amoebiasis
    102321231 (PIK3CA)
   05145 Toxoplasmosis
    102321231 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    102321231 (PIK3CA)
Enzymes [BR:phd01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102321231 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtatgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagagaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcatattccagacgcatctccacagctacgccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatttatgttcggacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaactggtccgta
tcccgtgaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaactctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaagcctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcggtgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtactaaag
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttaactaat
caaaggattggtcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatctgaag
caccttaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgccctccagggctttttgtctcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaggatatgctaacccttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggatgtctgtca
attggtgattgtgtgggacttattgaggtggtgagaaattctcacactataatgcagatt
cagtgtaaaggaggcctgaaaggtgcactgcagttcaacagccacacactccatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccatcgatttgtttacacggtca
tgtgctggatattgtgttgcaaccttcatcttgggaattggagatcgtcacaatagtaat
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgcgtgccctttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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