KEGG   Plasmodium knowlesi: PKH_052130Help
Entry
PKH_052130        CDS       T01094                                 

Definition
bifunctional dihydrofolate reductase-thymidylate synthase (EC:1.5.1.3 2.1.1.45)
Orthology
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
pkn  Plasmodium knowlesi
Pathway
Pyrimidine metabolism
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Brite
KEGG Orthology (KO) [BR:pkn00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    PKH_052130
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    PKH_052130
   00670 One carbon pool by folate
    PKH_052130
Enzymes [BR:pkn01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     PKH_052130
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     PKH_052130
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
5:936756..938636
Genome map
AA seq 626 aa AA seqDB search
MEDLSEVFDIYAICACCKVTPPNDGIKNEPFGPRTFRGLGNNGALPWKCNSVDMKYFSSV
TTYVDESKYEKLKWKRERYLQREASVGNVETHCGGDTVETEDNTTKLQNVVVMGRSSWES
IPKQYKPLPNRINVVLSKTLTHEQVKEKVFIIQSIDDLLLLLKKLKYYKCFIIGGAQVYK
ECLNRNLIKQIYFTRINNAYQCDVLFPQFDEGQFRMTSVSEVYNNKGTTLDFVIYSKVGG
EVDGGASNGSTMDMDSGSENCENVKCGAPNCNTSGCISPNCTSTREEKWRKCSPACQWKK
SNADVEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSVKIKQHPEYQYLSIIYDIIMNGNKQ
GDRTGVGVMSKFGYMMKFNLNEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLKKNVR
IWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEDKGVDQLKNVIHL
IKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNI
ASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEVKN
IEDFTISDFTIENYVHHDKIAMEMAA
NT seq 1881 nt NT seq  +upstreamnt  +downstreamnt
atggaagacctttcagaggtattcgatatttacgctatctgcgcctgctgcaaggtcacc
cctcctaatgatgggataaagaatgagccgtttggcccgcgaacctttaggggtcttgga
aataatggggctcttccatggaaatgcaactccgttgacatgaagtatttcagctcggtg
acgacctacgtagatgagtccaagtacgagaagttaaagtggaagagggagaggtacctg
caaagagaggcctcagtggggaatgttgaaacccactgtggtggtgacactgtagagacg
gaggataacaccaccaagctgcaaaacgttgtggtaatgggaagaagcagttgggagagc
attcccaaacagtacaaaccactcccaaacagaatcaatgtcgttctttccaagactcta
acacatgaacaggtgaaggaaaaagtttttataattcagagtatagatgacctactactt
cttttaaaaaagctgaagtactacaaatgcttcattattggaggagcacaagtttataag
gaatgtctaaataggaacttaattaagcagatatacttcacaaggattaacaacgcttat
cagtgtgatgttctgttcccacagtttgatgaaggtcagtttagaatgacatcggtcagc
gaggtgtacaacaacaagggcaccactctggactttgtgatttacagcaaggtagggggg
gaagtagatgggggcgcttccaatggaagcacgatggatatggatagtggttcggaaaac
tgcgagaatgtaaaatgtggcgcaccaaactgcaacacctccggttgtatctcccccaat
tgcacgagcacgcgtgaagagaaatggaggaagtgctcccccgcgtgtcagtggaagaag
agcaacgccgatgtagaggaagatgacctcgtatactttagctttaacaataaagtagga
gagaaaaacccagagcatctgcaggattttaaaatatataatagcgtcaagattaagcag
cacccagagtaccaatacctaagcatcatatatgacatcatcatgaatggaaacaaacaa
ggagatagaacaggtgtgggagtgatgagtaaatttgggtatatgatgaaatttaattta
aatgaatatttccccctattaacaacaaagaaattatttctgaggggaataattgaagag
ttgctctggttcattcggggagaaacaaacggaaacacattgttaaagaagaacgtgagg
atatgggaggcaaatggaacgagggagttccttgacaataggaaattatttcacagagaa
gtgaatgacctgggacctatttatggtttccagtggagacactttggtgctgaatacaca
aacatgtatgacaattacgaagataaaggtgtagaccaattaaaaaatgttatccattta
ataaaaaatgaaccaacgagtaggagaattatcctatgtgcatggaatgttaaagatttg
gatcaaatggctttacctccttgtcatatcttatgtcaattttacgttttcgatgggaaa
ctgtcatgcattatgtatcaaaggtcttgtgacttgggtcttggggtccccttcaacata
gcatcttattccatattcacacacatgattgcacaggtgtgcaatttacagcctgcacag
ttcatacacattttgggaaatgcccacgtctacaacaaccacatagacagcctaaaagtg
cagctaaacaggattccctaccccttcccaacgcttaagctgaacccggaagtgaagaac
attgaagattttaccatttcagatttcacaatagagaactatgtgcatcacgataaaatc
gctatggagatggccgcctag

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