KEGG   PATHWAY: pon00010Help
Entry
pon00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Pongo abelii (Sumatran orangutan)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
pon00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:pon00010]
Glycolysis, core module involving three-carbon compounds [PATH:pon00010]
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:pon00010]
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:pon00010]
Other DBs
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
HK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]
HKDC1; hexokinase domain containing 1 [KO:K00844] [EC:2.7.1.1]
HK3; hexokinase 3 (white cell) [KO:K00844] [EC:2.7.1.1]
HK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]
GCK; glucokinase (hexokinase 4) [KO:K12407] [EC:2.7.1.2]
GPI; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
PFKL; phosphofructokinase, liver [KO:K00850] [EC:2.7.1.11]
FBP2; fructose-1,6-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]
FBP1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
ALDOC; aldolase C, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
ALDOB; aldolase B, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
ALDOA; aldolase A, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
fructose-bisphosphate aldolase A-like; K01623 fructose-bisphosphate aldolase, class I [EC:4.1.2.13] [KO:K01623] [EC:4.1.2.13]
TPI1; triosephosphate isomerase 1 [KO:K01803] [EC:5.3.1.1]
GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
glyceraldehyde-3-phosphate dehydrogenase; K10705 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [EC:1.2.1.12] [KO:K10705] [EC:1.2.1.12]
PGK2; phosphoglycerate kinase 2 [KO:K00927] [EC:2.7.2.3]
PGK1; phosphoglycerate kinase 1 [KO:K00927] [EC:2.7.2.3]
PGAM2; phosphoglycerate mutase 2 (muscle) [KO:K01834] [EC:5.4.2.11]
PGAM1; phosphoglycerate mutase 1 (brain) [KO:K01834] [EC:5.4.2.11]
phosphoglycerate mutase 1-like; K01834 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] [KO:K01834] [EC:5.4.2.11]
ENO3; enolase 3 (beta, muscle) [KO:K01689] [EC:4.2.1.11]
ENO1; enolase 1, (alpha) [KO:K01689] [EC:4.2.1.11]
PKM2; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
PKLR; pyruvate kinase, liver and RBC [KO:K12406] [EC:2.7.1.40]
PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1 [KO:K00161] [EC:1.2.4.1]
PDHA2; pyruvate dehydrogenase (lipoamide) alpha 2 [KO:K00161] [EC:1.2.4.1]
PDHB; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
LDHAL6B; lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
LDHAL6A; lactate dehydrogenase A-like 6A [KO:K00016] [EC:1.1.1.27]
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.1 1.1.1.284]
ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase) [KO:K00002] [EC:1.1.1.2]
ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
ALDH3A1; aldehyde dehydrogenase 3 family, member A1 [KO:K00129] [EC:1.2.1.5]
ALDH3B1; aldehyde dehydrogenase 3 family, member B1 [KO:K00129] [EC:1.2.1.5]
ALDH1A3; aldehyde dehydrogenase 1 family, member A3 [KO:K00129] [EC:1.2.1.5]
ACSS1; acyl-CoA synthetase short-chain family member 1 [KO:K01895] [EC:6.2.1.1]
ACSS2; acyl-CoA synthetase short-chain family member 2 [KO:K01895] [EC:6.2.1.1]
GALM; galactose mutarotase (aldose 1-epimerase) [KO:K01785] [EC:5.1.3.3]
PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.7 5.4.2.2]
G6PC; glucose-6-phosphatase, catalytic subunit [KO:K01084] [EC:3.1.3.9]
G6PC2; glucose-6-phosphatase, catalytic, 2 [KO:K01084] [EC:3.1.3.9]
G6PC3; glucose 6 phosphatase, catalytic, 3 [KO:K01084] [EC:3.1.3.9]
ADPGK; ADP-dependent glucokinase [KO:K08074] [EC:2.7.1.147]
BPGM; 2,3-bisphosphoglycerate mutase [KO:K01837] [EC:3.1.3.13 5.4.2.11 5.4.2.4]
PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) [KO:K01596] [EC:4.1.1.32]
DKFZP469A0131 protein; K01596 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] [KO:K01596] [EC:4.1.1.32]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

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