KEGG   Pongo abelii (Sumatran orangutan): 100173813Help
Entry
100173813         CDS       T01416                                 

Gene name
CYP2E1
Definition
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.14.1)
Orthology
K07415  
cytochrome P450, family 2, subfamily E, polypeptide 1 [EC:1.14.13.-]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
Steroid hormone biosynthesis
Arachidonic acid metabolism
Linoleic acid metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Non-alcoholic fatty liver disease (NAFLD)
Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:pon00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    100173813 (CYP2E1)
   00590 Arachidonic acid metabolism
    100173813 (CYP2E1)
   00591 Linoleic acid metabolism
    100173813 (CYP2E1)
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    100173813 (CYP2E1)
   00982 Drug metabolism - cytochrome P450
    100173813 (CYP2E1)
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    100173813 (CYP2E1)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100173813 (CYP2E1)
Enzymes [BR:pon01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     100173813 (CYP2E1)
Cytochrome P450 [BR:pon00199]
 Cytochrome P450, animal type
  CYP2 family
   100173813 (CYP2E1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
10
AA seq 524 aa AA seqDB search
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNVPKSFTRL
AQRFGPVFTLYVGSQRVVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHKDRGIIFNNGP
TWKEIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCTPCNVI
ADILFRKRFDYNDEKFLRLMYLFNENFYLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAEPLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHKATRDTIFRGYLIPKGTVIVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRHECVEDTLNPPLSNKFSNCLRSGFLKLIPFVA
NT seq 1575 nt NT seq  +upstreamnt  +downstreamnt
atgtctgccctcggagtcaccgtggccctgctggtgtgggcggccttcctcctgctggtg
tccatgtggaggcaggtgcacagcagctggaatctgcctccaggccctttcccacttccc
atcatcgggaacctcttccagttggaattgaagaatgttcccaagtccttcacccggctg
gcccagcgcttcgggccggtgttcacgctgtacgtgggctctcagcgcgtggtggtgatg
cacggctacaaggcggtgaaggaagcgctgctggactacaaggacgagttctcgggcaga
ggcgacctccccgcgttccatgcgcacaaggacaggggaatcatttttaataatggacct
acctggaaggagatccggcggttttccctgaccaccctccggaactatgggatggggaaa
cagggcaacgagagccggatccagagggaggcccacttcctgctggaagcactcaggaag
acccaaggccagccttttgaccccaccttcctcattggctgcacaccctgcaacgtcata
gccgacatcctcttccgcaagcgttttgactacaatgatgagaagtttctaaggctgatg
tatttgtttaatgagaacttctacctactcagcactccctggctccagctttacaataat
tttcccagctttctacactacttgcctggaagccatagaaaagtcataaaaaatgtggct
gaagtaaaagagtatgtgtctgaaagggtgaaggagcaccatcaatctctggaccccaac
tgtccccgggacctcaccgactgcctgctcgtggaaatggagaaggagaagcacagtgca
gagcccttgtacacaatggatggtatcactgtgactgtggccgacctgttctttgcgggg
acagagaccaccagcacaactctgagatatgggctcctgattctcatgaaataccctgag
atcgaagagaagctccatgaagaaattgacagggtgattgggccaagccgaatccctgcc
atcaaggataggcaagagatgccctacatggatgctgtggtgcatgagattcagcggttc
atcaccctcgtgccctccaacctgccccataaagcaacccgagacaccattttcagagga
tacctcatccccaagggcacagtcatagtgccaactctggactctgttttgtatgacaac
caagaatttcctgatccagaaaagtttaagccagaacacttcctgaatgaaaatgggaag
ttcaagtacagtgactatttcaagccattttccacaggaaaacgagtgtgtgctggagaa
ggcctggctcgcatggagttgtttctattgttgtgtgccattttgcagcattttaatttg
aagcctctcgttgacccaaaggatatcgacctcagccctatacatattgggtttggctgt
atcccaccacgttacaaactctgtgtcattccccgccatgagtgtgtggaggacaccctg
aatcccccgctttcaaacaagttttcgaattgtttgaggtcaggatttctcaaactgatt
cctttcgttgcataa

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