KEGG   Pongo abelii (Sumatran orangutan): 100432846Help
Entry
100432846         CDS       T01416                                 

Gene name
PIK3CB
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100432846 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100432846 (PIK3CB)
   04015 Rap1 signaling pathway
    100432846 (PIK3CB)
   04012 ErbB signaling pathway
    100432846 (PIK3CB)
   04370 VEGF signaling pathway
    100432846 (PIK3CB)
   04630 Jak-STAT signaling pathway
    100432846 (PIK3CB)
   04668 TNF signaling pathway
    100432846 (PIK3CB)
   04066 HIF-1 signaling pathway
    100432846 (PIK3CB)
   04068 FoxO signaling pathway
    100432846 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100432846 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    100432846 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100432846 (PIK3CB)
   04152 AMPK signaling pathway
    100432846 (PIK3CB)
   04150 mTOR signaling pathway
    100432846 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100432846 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    100432846 (PIK3CB)
  Cell communication
   04510 Focal adhesion
    100432846 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100432846 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100432846 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100432846 (PIK3CB)
   04660 T cell receptor signaling pathway
    100432846 (PIK3CB)
   04662 B cell receptor signaling pathway
    100432846 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100432846 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100432846 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100432846 (PIK3CB)
   04062 Chemokine signaling pathway
    100432846 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    100432846 (PIK3CB)
   04915 Estrogen signaling pathway
    100432846 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100432846 (PIK3CB)
   04917 Prolactin signaling pathway
    100432846 (PIK3CB)
   04921 Oxytocin signaling pathway
    100432846 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100432846 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100432846 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100432846 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100432846 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    100432846 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100432846 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100432846 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    100432846 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100432846 (PIK3CB)
   05205 Proteoglycans in cancer
    100432846 (PIK3CB)
   05203 Viral carcinogenesis
    100432846 (PIK3CB)
   05210 Colorectal cancer
    100432846 (PIK3CB)
   05212 Pancreatic cancer
    100432846 (PIK3CB)
   05214 Glioma
    100432846 (PIK3CB)
   05221 Acute myeloid leukemia
    100432846 (PIK3CB)
   05220 Chronic myeloid leukemia
    100432846 (PIK3CB)
   05218 Melanoma
    100432846 (PIK3CB)
   05211 Renal cell carcinoma
    100432846 (PIK3CB)
   05215 Prostate cancer
    100432846 (PIK3CB)
   05213 Endometrial cancer
    100432846 (PIK3CB)
   05222 Small cell lung cancer
    100432846 (PIK3CB)
   05223 Non-small cell lung cancer
    100432846 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100432846 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100432846 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100432846 (PIK3CB)
   05166 HTLV-I infection
    100432846 (PIK3CB)
   05162 Measles
    100432846 (PIK3CB)
   05164 Influenza A
    100432846 (PIK3CB)
   05161 Hepatitis B
    100432846 (PIK3CB)
   05160 Hepatitis C
    100432846 (PIK3CB)
   05169 Epstein-Barr virus infection
    100432846 (PIK3CB)
   05146 Amoebiasis
    100432846 (PIK3CB)
   05145 Toxoplasmosis
    100432846 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    100432846 (PIK3CB)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100432846 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
3
AA seq 1070 aa AA seqDB search
MCFSFIMPPAMADILDIWAVDSQIASDGSILVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacttgtggatttccttttgcccactgggatt
tacatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattggactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaaaatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcattgtagct
gttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtgatgaacaggaccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatctaatcttcctcttccgttaccaccaaagaaaaca
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctcaaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcaacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttgaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaagggaaggag
gccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcctgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttggcattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacac
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgccagtgttgtgaagatgcatatctgattttacgacggcatgggaatctcttc
atcactctctttgcgctgatgttgactgcagggcttcctgaactcacatcagtcaaagat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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