KEGG   Pongo abelii (Sumatran orangutan): 100434502Help
Entry
100434502         CDS       T01416                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pon00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100434502 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100434502 (PLCB1)
   04310 Wnt signaling pathway
    100434502 (PLCB1)
   04020 Calcium signaling pathway
    100434502 (PLCB1)
   04070 Phosphatidylinositol signaling system
    100434502 (PLCB1)
   04022 cGMP - PKG signaling pathway
    100434502 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100434502 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100434502 (PLCB1)
   04062 Chemokine signaling pathway
    100434502 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    100434502 (PLCB1)
   04912 GnRH signaling pathway
    100434502 (PLCB1)
   04915 Estrogen signaling pathway
    100434502 (PLCB1)
   04921 Oxytocin signaling pathway
    100434502 (PLCB1)
   04918 Thyroid hormone synthesis
    100434502 (PLCB1)
   04919 Thyroid hormone signaling pathway
    100434502 (PLCB1)
   04916 Melanogenesis
    100434502 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100434502 (PLCB1)
   04270 Vascular smooth muscle contraction
    100434502 (PLCB1)
  Digestive system
   04970 Salivary secretion
    100434502 (PLCB1)
   04971 Gastric acid secretion
    100434502 (PLCB1)
   04972 Pancreatic secretion
    100434502 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100434502 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    100434502 (PLCB1)
   04725 Cholinergic synapse
    100434502 (PLCB1)
   04728 Dopaminergic synapse
    100434502 (PLCB1)
   04726 Serotonergic synapse
    100434502 (PLCB1)
   04720 Long-term potentiation
    100434502 (PLCB1)
   04730 Long-term depression
    100434502 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    100434502 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100434502 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    100434502 (PLCB1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100434502 (PLCB1)
   05016 Huntington's disease
    100434502 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    100434502 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    100434502 (PLCB1)
   05143 African trypanosomiasis
    100434502 (PLCB1)
Enzymes [BR:pon01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100434502 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
20
AA seq 1214 aa AA seqDB search
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVELYNKMQLSRIYPKGT
RVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHF
DPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNA
VNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQ
PLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEA
DPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVL
TEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRR
RAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQE
QYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITE
AKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKL
QVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEE
LGGDIPGKEFDTPL
NT seq 3645 nt NT seq  +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctactggatctcagccttgtcaaagatgccagatgtgggagacacgccaaagct
cccaaggaccctaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcag
cgcatgatcacagtggtgtatgggcctgacctcgtgaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgc
cctcgacctgaaattgataacatcttttcagaatttggtgcaaaaagcaaaccatatctt
accgttgatcagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaa
atactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aacaatagcctcgccagaaaaggacaaatatcagtggatgggttcatgcgctatctgagt
ggagaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
ccactttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagctggactgctggaagggacggactgcagaagaggaacctgtcatcacccatggcttc
accatgacaactgaaatatctttcaaggaagtgatagaagcaattgcggagtgtgcattt
aagacttcaccttttccaattctcctttcatttgagaaccatgtggattccccaaagcag
caagccaagatggcggagtactgccgactgatctttggggatgcccttctcatggagccc
ctggaaaaatatccactggaatctggagttcctcttccaagccctatggatttaatgtat
aaaattttggtgaaaaataagaagaaatcacataagtcatcagaaggaagcggcaaaaag
aagctctcagaacaagcctccaacacctacagtgactcctccagcgtgttcgagccctca
tccccaggagccggagaagctgatacggaaagtgacgacgacgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaagaaatg
tctaacctggtgaactatattcagccagtcaagtttgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcacc
aagtctccggtggaattatataacaaaatgcagcttagcaggatatatccaaaaggaaca
cgtgtggattcatccaactatatgcctcagctcttctggaatgcaggttgtcagatggtg
gcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtatgaatac
aacgggaagagtggctacagattgaagccagagttcatgaggaggcctgacaagcatttt
gatccatttactgaaggcatcgtagatgggatagtggcaaacactttgtctgttaagatt
atttcaggtcagtttctttctgataagaaagttgggacttacgtggaagtggatatgttt
ggtttgcctgtggatacaaggaggaaggcatttaagaccaaaacatcccaaggaaatgct
gtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcctactctg
gcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgtatcttg
ccagtgcaagccattcggccagggtatcactatatctgtctaaggaatgaaaggaaccag
cctctgacgctgcctgctgtctttgtctacatagaagtgaaagactatgtgccagacaca
tatgcagatgtcattgaagctttatcaaacccaatccgatatgtgaacctgatggaacag
agagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaagaggct
gatcctggagaaacaccatcagaggctccaagtgaagcgagaacgactccagcagaaaac
ggggtgaatcacaccacaaccctgacacccaaaccaccctcccaggctctccacagccag
ccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagtgtctta
acagaagtggaagcacagaccatcgaagaactaaagcaacagaaatcgtttgtgaaactt
caaaagaaacactacaaagaaatgaaagacctggttaagagacaccacaagaaaaccact
gaccttatcaaagaacacactaccaagtataatgaaattcagaatgactacttgagaagg
agagcagccttggaaaagtctgccaaaaaggacagtaagaaaaaatcggaacccagcagc
cctgatcatggttcatcaacgattgagcaagacctcgctgccctggatgctgaaatgacc
caaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcggcaagaa
cagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaaaagttg
acggatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatctgtgag
aaagaaaagaaagaattaaagaagaaaatggataaaaagaggcaggagaagataacagaa
gctaaatccaaagacaaaagtcagatggaagaggagaagacagagatgatccggtcatat
atccaggaagtggtgcagtatatcaagaggctagaagaagcgcaaagtaaacgacaagaa
aaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagcccaagctg
caggtggagctggagcaagaataccaagacaaattcaaaagactgcccctcgagattttg
gaattcgtgcaggaagccatgaaaggaaagatcagtgaagacagcaatcacggttctgcc
cctctctccctgtcctcagaccctggaaaagtgaaccacaagactccctccagtgaggaa
ctgggaggagacatcccaggaaaagaatttgatactcctctgtga

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