KEGG   Pongo abelii (Sumatran orangutan): 100442255Help
Entry
100442255         CDS       T01416                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Class
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:pon04068]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:pon04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:pon04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:pon04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:pon04920]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:pon04960]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:pon04722]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:pon05206]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:pon04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:pon04932]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
2B
AA seq 1247 aa AA seqDB search
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GQYVLSRGGNGHRYTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGSSYGKLWTNGVGGHHSHVLPHPKPPVES
SSGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPENPQHKPVLSYYSLPRSFKHTQHPGEP
EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH
LPRKVDTAAQTNSRLARPTLLSLGDPKASTLPRAREQQQQQQQQQQQPLLHPPEPKSPGE
YVNIEFGSDQPGYLSGPVASHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQ
ESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADM
RTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRV
NLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSS
EDVKRHSSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQRPQEC
TPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ
NT seq 3744 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgcttcttcgtactgcgcgctgccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgagacgagcactttgccatcgcggcggacagcgag
gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac
cacgacggagctgctgccctcggtgcgggaggtggtgggggcagctgcagtggcagctcc
ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc
aaagaggtctggcaggtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt
ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcagccgccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggagaacttc
ttcttcatcgaggtgggccgttctgccgtgacgggtcccggggagttctggatgcaggtg
gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg
agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc
agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc
cgccgatcgcgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag
ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcactatgtcccgcccagcc
tcggtagacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg
ggcagcgcccggctgcaccccccgctcaaccacagccgttccatccccatgccggcttcc
cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat
ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc
agcgatggcggtttcatctcctcagatgagtatggctccagtccctgtgattttcggagt
tccttccgcagcgtcactccggattccctgggccacaccccaccagcccgcggtgaggag
gagctaagcaactatatctgcatgggtggcaaggggccctccaccctgaccgcccccaac
ggtcaatacgttttgtctcggggtggcaatggccaccgctacaccccaggaacaggcttg
ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg
ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg
tcccagtcctcagtggcttccattgaggagtatacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccac
tcctacccagaggagggtctggaaatgcaccccttggagcgtcgggggggccaccaccgc
ccagacagctccaccctccacactgatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccagcagccgaaagggcagtggagactatatgcccatgagtcccaagagcgtg
tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc
agcagcagcagcagcagcaatgctgtcccttccgggagcagctatggaaagctgtggaca
aacggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagc
agcagtggtaagctcttaccttgtacaggtgactacatgaacatgtcaccagtgggggac
tccaacaccagcagcccctccgactgctactacggccctgagaacccccagcacaagcca
gtcctctcctactactcattgccaagatcctttaagcacacccagcaccctggggagccg
gaggagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctat
gctgcaacagcggatgattcttcctcctccaccagcagtgacagcctgggtgggggatac
tgcggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccat
ctgcctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgttg
ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcag
cagcagcagcagcagcagcagcccctgctgcaccctccagagcccaagagcccaggggaa
tatgtcaatattgaatttgggagtgatcagcctggctacttgtctggcccggtggcttcc
cacagctcaccttctgtcaggtgtccatcccagctccagccagctcccagagaggaagag
actggcactgaggagtacatgaagatggacctggggccgggccggagggcagcctggcag
gagagcactggggtcgagatgggcagactgggccccgcacctcccggggctgctagcatt
tgcaggcctacccgggcagtgcccagcagccggggtgactacatgaccatgcagatgagt
tgtccccgtcagagctacgtggacacctcgccagctgcccctgtaagctatgctgacatg
cggacaggcattgctgcagaggaggtgagcctgccgagggccaccatggctgctgcctcc
tcatcctcagcagcctctgcttccccgactgggcctcaaggggcagcagagctggctgcc
cactcgtccctgctggggggcccacaaggacctgggggcatgagcgccttcacccgggtg
aacctcagtcctaaccgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgc
cggcggaggcatagctccgagaccttctcctcaacacccagtgccactcgggtgggcaac
acagtgccctttggagcaggggcagcagtagggggcggtggcggtagcagcagcagcagc
gaggatgtgaaacgccacagctctgcttcctttgagaatgtgtggctgaggcctggggag
cttgggggagcccccaaggagccagcccaactgtgtggggctgctgggggtttggagaat
ggtcttaactacatagacctggatttggtcaaggacttcaaacagcgccctcaggagtgc
acccctgaaccgcagcctcccccacccccaccccctcatcaacccctgggcagcggtgag
agcagctccacccgccgctcaagtgaggatttaagcgcctatgccagcatcagtttccag
aagcagccagaggaccgtcagtag

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