KEGG   Pongo abelii (Sumatran orangutan): 100446021Help
Entry
100446021         CDS       T01416                                 

Gene name
MAP2K1
Definition
mitogen-activated protein kinase kinase 1
Orthology
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Dorso-ventral axis formation
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100446021 (MAP2K1)
   04015 Rap1 signaling pathway
    100446021 (MAP2K1)
   04010 MAPK signaling pathway
    100446021 (MAP2K1)
   04012 ErbB signaling pathway
    100446021 (MAP2K1)
   04370 VEGF signaling pathway
    100446021 (MAP2K1)
   04668 TNF signaling pathway
    100446021 (MAP2K1)
   04066 HIF-1 signaling pathway
    100446021 (MAP2K1)
   04068 FoxO signaling pathway
    100446021 (MAP2K1)
   04024 cAMP signaling pathway
    100446021 (MAP2K1)
   04022 cGMP - PKG signaling pathway
    100446021 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    100446021 (MAP2K1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100446021 (MAP2K1)
  Cell growth and death
   04114 Oocyte meiosis
    100446021 (MAP2K1)
  Cellular commiunity
   04510 Focal adhesion
    100446021 (MAP2K1)
   04540 Gap junction
    100446021 (MAP2K1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    100446021 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    100446021 (MAP2K1)
   04660 T cell receptor signaling pathway
    100446021 (MAP2K1)
   04662 B cell receptor signaling pathway
    100446021 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    100446021 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    100446021 (MAP2K1)
   04062 Chemokine signaling pathway
    100446021 (MAP2K1)
  Endocrine system
   04910 Insulin signaling pathway
    100446021 (MAP2K1)
   04912 GnRH signaling pathway
    100446021 (MAP2K1)
   04915 Estrogen signaling pathway
    100446021 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    100446021 (MAP2K1)
   04917 Prolactin signaling pathway
    100446021 (MAP2K1)
   04921 Oxytocin signaling pathway
    100446021 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    100446021 (MAP2K1)
   04916 Melanogenesis
    100446021 (MAP2K1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    100446021 (MAP2K1)
  Nervous system
   04725 Cholinergic synapse
    100446021 (MAP2K1)
   04726 Serotonergic synapse
    100446021 (MAP2K1)
   04720 Long-term potentiation
    100446021 (MAP2K1)
   04730 Long-term depression
    100446021 (MAP2K1)
   04722 Neurotrophin signaling pathway
    100446021 (MAP2K1)
  Development
   04320 Dorso-ventral axis formation
    100446021 (MAP2K1)
   04380 Osteoclast differentiation
    100446021 (MAP2K1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100446021 (MAP2K1)
   05206 MicroRNAs in cancer
    100446021 (MAP2K1)
   05205 Proteoglycans in cancer
    100446021 (MAP2K1)
   05210 Colorectal cancer
    100446021 (MAP2K1)
   05212 Pancreatic cancer
    100446021 (MAP2K1)
   05214 Glioma
    100446021 (MAP2K1)
   05216 Thyroid cancer
    100446021 (MAP2K1)
   05221 Acute myeloid leukemia
    100446021 (MAP2K1)
   05220 Chronic myeloid leukemia
    100446021 (MAP2K1)
   05218 Melanoma
    100446021 (MAP2K1)
   05211 Renal cell carcinoma
    100446021 (MAP2K1)
   05219 Bladder cancer
    100446021 (MAP2K1)
   05215 Prostate cancer
    100446021 (MAP2K1)
   05213 Endometrial cancer
    100446021 (MAP2K1)
   05223 Non-small cell lung cancer
    100446021 (MAP2K1)
  Neurodegenerative diseases
   05020 Prion diseases
    100446021 (MAP2K1)
  Substance dependence
   05034 Alcoholism
    100446021 (MAP2K1)
  Infectious diseases
   05164 Influenza A
    100446021 (MAP2K1)
   05161 Hepatitis B
    100446021 (MAP2K1)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100446021 (MAP2K1)
Protein kinases [BR:pon01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   100446021 (MAP2K1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
15
AA seq 422 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHREIKTSWLLFNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVWEVHPIPPPDAKELXELMFGCQVEGDAGXIDHHLRAKDPWEA
PXPVSSLGPTENLPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLN
ATHGKSVYSRFLQYLFIHLFFSVHAFYQRDLMLREVDFAGWLCSNHRALTQPQHTQPHAV
GV
NT seq 1269 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcggtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggtttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagaaattaagaccagctggttgttattcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactctatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctctggtagagatggcggtttgggag
gttcatcccatccctcctccagatgccaaggagctgtaagagctgatgtttgggtgccag
gtggagggagatgcgggctgaattgaccaccacctaagggccaaggacccctgggaggcc
ccttagcctgtgagtagcctgggcccaaccgaaaacctacccatggcaatttttgagttg
ttggattacatagtcaacgagcctcctccaaaactgcccagtggagtgttcagtctggaa
tttcaagattttgtgaataaatgcttaataaaaaaccccgcagagagagcagatttgaat
gcaactcatggtaagtctgtttattccagattcttacagtacctgtttattcatttgttc
ttctctgttcatgctttttatcaaagagatctgatgctgagggaagtggattttgcaggt
tggctctgctccaaccatcgggccttaacccagccccagcacacccaaccccatgctgtt
ggcgtctaa

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