KEGG   Pongo abelii (Sumatran orangutan): 100450941Help
Entry
100450941         CDS       T01416                                 

Gene name
PLCG1
Definition
phospholipase C, gamma 1
Orthology
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pon00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100450941 (PLCG1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100450941 (PLCG1)
   04015 Rap1 signaling pathway
    100450941 (PLCG1)
   04012 ErbB signaling pathway
    100450941 (PLCG1)
   04370 VEGF signaling pathway
    100450941 (PLCG1)
   04064 NF-kappa B signaling pathway
    100450941 (PLCG1)
   04066 HIF-1 signaling pathway
    100450941 (PLCG1)
   04020 Calcium signaling pathway
    100450941 (PLCG1)
   04070 Phosphatidylinositol signaling system
    100450941 (PLCG1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100450941 (PLCG1)
   04660 T cell receptor signaling pathway
    100450941 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    100450941 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    100450941 (PLCG1)
   04670 Leukocyte transendothelial migration
    100450941 (PLCG1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100450941 (PLCG1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100450941 (PLCG1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100450941 (PLCG1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100450941 (PLCG1)
   05231 Choline metabolism in cancer
    100450941 (PLCG1)
   05206 MicroRNAs in cancer
    100450941 (PLCG1)
   05205 Proteoglycans in cancer
    100450941 (PLCG1)
   05214 Glioma
    100450941 (PLCG1)
   05223 Non-small cell lung cancer
    100450941 (PLCG1)
  Infectious diseases
   05169 Epstein-Barr virus infection
    100450941 (PLCG1)
Enzymes [BR:pon01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100450941 (PLCG1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
20
AA seq 1257 aa AA seqDB search
MTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQ
EDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIE
RWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA
QLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQ
EFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSS
HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVL
HTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQ
LKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTS
SKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCI
ETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYD
LITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVR
KRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRY
PINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTK
SAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRG
VLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTAD
ARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNK
VKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALF
MTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISVEVLGARHLPKNGRGIVCPFVEI
EVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQIINPEFAFLRFVVYEEDMFSDQNFLA
QATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKQENGDLSPFSGTSLRERGS
DASGQLFHGRAREGSFESRYQQPFEDFRISQEHLTDHFDSRERRAPRRTRVNGDNRL
NT seq 3774 nt NT seq  +upstreamnt  +downstreamnt
atgactttgttctactccaagaagtcgcagcgaccagagcggaagaccttccaggtcaag
ctggagacgcgccagatcacgtggagccgtggtgccgacaagatcgagggggccattgat
attcgtgaaattaaggagatccgcccagggaagacctcacgggactttgatcgctatcaa
gaggacccagctttccggccggaccagtcacattgctttgtcattctctatggaatggaa
tttcgcctgaaaacgctgagcctgcaagccacatctgaggatgaagtgaacatgtggatc
aagggcttaacttggctgatggaggatacattgcaggcacccacaccgctgcagattgag
aggtggctccggaagcagttttactcagtggatcggaatcgtgaggatcgtatatcagcc
aaggacctgaagaacatgctgtcccaggtcaactaccgggtccccaacatgcgcttcctc
cgagagcggctgacggacctggagcagcgcagcggggacatcacctacgggcagtttgct
cagctgtaccgcagcctcatgtacagcgcccagaagacgatggacctccccttcttggaa
gccagtactctgagggctggggagcggccggagctttgccgagtgtcccttcctgagttc
cagcagttccttcttgactaccagggggagctgtgggctgttgatcgcctccaggtgcag
gagttcatgctcagcttcctccgagaccccttacgagagatcgaggagccatacttcttc
ctggatgagtttgtcaccttcctgttctccaaagagaacagtgtgtggaactcacagctg
gatgcagtatgcccggacaccatgaacaaccctctttcccactactggatctcctcctcg
cacaacacgtacctgaccggggaccagttctccagtgagtcctccttggaagcctatgct
cgctgcctgcggatgggctgtcgctgcattgagttggactgctgggacggcccagatggg
atgccagttatttaccatggtcacacccttaccaccaagatcaagttctcagatgtcctg
cataccatcaaggagcatgcctttgtggcctcagagtacccagtcatcctgtccattgag
gaccactgcagcattgcccagcagaggaacatggcccagtacttcaagaaggtgctgggg
gacacactcctcaccaagcccgtggagatctccgccgatgggctcccctcacccaaccag
cttaagaggaagatccttatcaagcacaagaagctggctgagggcagtgcctatgaggag
gtgcctacatccatgatgtactctgagaacgacatcagcaactccatcaagaatggcatc
ctctacctggaggaccctgtgaaccacgaatggtatccccactactttgttctgaccagc
agcaagatctactactctgaggagaccagcagtgaccagggcaacgaggatgaggaggag
cccaaggaggtcagcagcagcacagagctgcactccaatgagaagtggttccatgggaag
ctaggggcagggcgtgacgggcgtcacatcgctgagcgcctgctcactgagtactgcatc
gagactggagcccctgacggctccttcctcgtgcgagagagtgagaccttcgtgggcgac
tacacgctctctttctggcggaacgggaaagtccagcactgccgtatccactcccggcaa
gatgctgggacccccaagttcttcttgacagacaacctcgtctttgactccctctatgac
ctcatcacacactaccagcaggtgcccctgcgctgtaatgagtttgagatgcgactttca
gagcctgtcccacagaccaacgcccacgagagcaaagagtggtaccacgcgagcctgacc
agagcacaggctgagcacatgctaatgcgcgtccctcgtgatggggccttcctggtgcgg
aagcggaatgagcccaactcatatgccatctctttccgggctgagggcaagatcaagcat
tgccgtgtccagcaagagggccagacagtgatgctagggaactcggagttcgacagcctt
gttgacctcatcagctactatgagaaacacccactataccgcaagatgaagctgcgctat
cccatcaacgaggaggcattggagaagattggcacagctgagcctgactacggggccctg
tatgagggacgcaaccctggcttctatgtagaggcaaaccctatgccaactttcaagtgt
gcggtcaaagccctctttgactacaaggcccagagggaggacgagctgaccttcaccaag
agcgccatcatccagaatgtggagaagcaagagggaggctggtggcgaggggactacgga
gggaagaagcagctgtggttcccatcaaactatgtggaagagatggtcaaccccgtggcc
ctggagccggagagggagcacttggacgagaacagccccctaggggacttgctgcggggc
gtcttggatgtgccggcttgtcagattgccatccgtcctgagggcaagaacaaccggctc
ttcgtcttctccatcagcatggcgtcggtggcccactggtccctggatgttgctgccgac
tcacaggaggagctgcaggactgggtgaaaaagatccgtgaagtggcccagaccgcagat
gccaggctcactgaagggaagataatggaacggaggaagaagattgccctggagctctct
gaacttgtcgtctactgccggcctgttcccttcgatgaagagaagattggcacagaacgt
gcttgctaccgggacatgtcatccttcccggaaaccaaggctgagaaatacgtgaacaag
gtcaaaggcaagaagttccttcagtacaatcgactgcagctctcccgcatctaccccaag
ggccagcgactggattcctccaactacgatcctttgcccatgtggatctgtggcagtcag
ctcgtggccctcaacttccagacccctgacaagcctatgcagatgaaccaggccctcttc
atgacgggcaggcactgtggctacgtgctgcagccaagcaccatgcgggatgaggccttc
gacccctttgacaagagcagcctccgcgggctggagccatgtgccatctctgttgaggtg
ctgggggcccgacatctgccaaagaatggccgaggcattgtgtgtccttttgtggagata
gaggtggctggagctgagtatgacagcaccaagcagaagacagagtttgtggtggacaat
ggactcaaccctgtatggccagccaagcccttccacttccagatcattaaccctgaattt
gcctttctgcgcttcgtggtgtatgaggaagacatgtttagtgaccagaatttcttggct
caggctactttcccagtaaaaggcctgaagacaggatacagagcagtgcctttgaagaac
aactacagtgaggacctggagttggcctccctgctgatcaagattgacattttccctgcc
aagcaggagaatggtgacctcagtcccttcagtggtacgtccctgcgggagcggggctca
gatgcctcaggccagctgtttcacggccgagcccgggaaggctcctttgaatcccgctac
cagcagccatttgaggacttccgcatctcccaggagcatctcacagaccattttgacagt
cgagaacgaagggccccaagaaggactcgggtcaatggagacaaccgcctctag

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