KEGG   Pongo abelii (Sumatran orangutan): 100458716Help
Entry
100458716         CDS       T01416                                 

Gene name
PLCB2
Definition
phospholipase C, beta 2
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pon00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100458716 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100458716 (PLCB2)
   04310 Wnt signaling pathway
    100458716 (PLCB2)
   04020 Calcium signaling pathway
    100458716 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100458716 (PLCB2)
   04022 cGMP - PKG signaling pathway
    100458716 (PLCB2)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100458716 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100458716 (PLCB2)
   04062 Chemokine signaling pathway
    100458716 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    100458716 (PLCB2)
   04912 GnRH signaling pathway
    100458716 (PLCB2)
   04915 Estrogen signaling pathway
    100458716 (PLCB2)
   04921 Oxytocin signaling pathway
    100458716 (PLCB2)
   04918 Thyroid hormone synthesis
    100458716 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100458716 (PLCB2)
   04916 Melanogenesis
    100458716 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100458716 (PLCB2)
   04270 Vascular smooth muscle contraction
    100458716 (PLCB2)
  Digestive system
   04970 Salivary secretion
    100458716 (PLCB2)
   04971 Gastric acid secretion
    100458716 (PLCB2)
   04972 Pancreatic secretion
    100458716 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100458716 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    100458716 (PLCB2)
   04725 Cholinergic synapse
    100458716 (PLCB2)
   04728 Dopaminergic synapse
    100458716 (PLCB2)
   04726 Serotonergic synapse
    100458716 (PLCB2)
   04720 Long-term potentiation
    100458716 (PLCB2)
   04730 Long-term depression
    100458716 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100458716 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100458716 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    100458716 (PLCB2)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100458716 (PLCB2)
   05016 Huntington's disease
    100458716 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    100458716 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    100458716 (PLCB2)
   05143 African trypanosomiasis
    100458716 (PLCB2)
Enzymes [BR:pon01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100458716 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
15
AA seq 1145 aa AA seqDB search
MSLLNPVLLPPKVKAYMSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRLSGSLPRWPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYK
ENVGKVWAEDVLALVKHPADGTPSRSTFLDKILVKLKMQLNSXREEFPVKNFFQMFPADR
KRVEAALSACHLPKRQSYYAPQNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKA
KPYHDERSTLTKIPSTQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEG
MVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLL
SGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENH
VDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPRGISGAKILIKNKKNQFSG
PTSSSKDPGGEAEGSSPPSAPAGERTVWAGEDGTELEEEEVEEEEEEESGNLDEEEIKKM
QSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKAS
VQFVEYPXATTKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMLPSTFQTMDLPMQQNMAV
FEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITILMPELASLRVAVMEEGN
KFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYVPGAWADLTVALANPI
KFFSAHDKKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKE
AAEPRTASLEELRELKAVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVG
GVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYE
CVLKRKEQHAAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTK
VTADKMAQERLKREINNSHIQEVVQVIKQMTENLEGHQEKLEEKQAACLEQIREMEKQFQ
KEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLVAKADA
QESRL
NT seq 3438 nt NT seq  +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtcctgctgccccccaaggtgaaggcctatatgagccaaggg
gagcgcttcatcaaatgggatgatgaaactacagttgcctctccagttatcctccgtgtg
gatcctaagggctactacttatactggacgtatcaaagtaaggagatggagtttctggat
atcaccagcatccgggatactcgactttcgggaagtttgccaagatggcccaagagccag
aagctccgggacgtcttcaacatggactttcctgacaacagcttcctgctgaagacactc
acggtggtgtccggcccggacatggtggacctcaccttccacaacttcgtctcctacaag
gagaacgtgggcaaggtctgggctgaggacgtactggccctagtcaagcatcccgctgac
ggcacgccctcccgcagcaccttcctggacaagatccttgtgaagctcaagatgcagctc
aactcctgaagggaagaattcccggtgaagaactttttccagatgtttcctgctgaccgc
aagcgggtggaagctgctctcagtgcctgccacctccccaaaaggcaaagttactatgcc
ccccagaatgacgccatcaatcctgaggacttcccagaacctgtctacaagagtttcctc
atgagcctctgtcctcggccagaaatagatgagatcttcacttcttaccatgctaaggcc
aaaccctaccatgacgaaaggagcaccctgaccaaaattccatcaacccagaaacagcgg
gactcccggcttaactccctgctgttcccgccagcacggcctgaccaggtgcagggcctc
atcgacaagtatgagcccagtggcatcaatgtgcagaggggccagctgtcacctgagggc
atggtctggtttctctgtgggccagagaacagtgtgctggctcaggacaagctgctgctc
caccacgacatgacgcagccactcaatcattacttcatcaactcgtcccacaacacctac
ctgacagccggccagttctcaggcctctcctcggctgagatgtaccgccaggtgctgctc
tctggctgccgttgcgtggagctagactgctggaaggggaaaccccctgacgaggagccc
attatcacccacggcttcaccatgaccacagacatcttcttcaaagaagcaattgaggct
attgcagaaagtgcctttaagacctccccctatcccatcatcctgtcgtttgagaaccac
gtggactcaccccgccagcaggctaagatggctgagtattgccggaccatctttggggat
atgctgctcacagagcccctggaaaagttcccgctaaaaccaggtgtcccccttcccagc
ccccgagggatctcaggggcaaagatcctcatcaagaacaagaagaaccagttttctggc
cccacctcctccagtaaggatcctggtggggaggctgagggcagcagcccacccagtgcc
cctgcaggtgagcgcacagtgtgggctggcgaggatgggactgagctggaggaggaggag
gtggaagaggaagaggaggaggagtcaggaaacctggacgaagaagagattaagaagatg
cagtcggatgagggcacagcgggcctggaagtgacggcttatgaggagatgtccagccta
gtcaattacatccagcccaccaagttcatctcctttgagttctctgcccaaaagaaccga
agttatgtcatctcatccttcacagagctcaaggcatatgacctgctctccaaggcctcg
gtgcagtttgtggagtatccttgagctacaacaaagcgccagatgagccgcatttacccc
aagggaacccgcatggactcctccaactacatgccccagatgttctggaatgctggatgc
cagatgttgccctcaactttccagacgatggacttgcccatgcagcagaacatggcagtg
tttgagttcaacgggcagagcggctacctcctcaagcacgagttcatgcgccggccagac
aagcagttcaaccccttctcagtggatcgcatcgacgtggtggtggccaccaccctttcc
atcacgatcttgatgcctgagctggcctccctcagggtggctgtgatggaggaaggcaac
aagtttcttggacaccgcatcatccccatcaatgccctaaattctgggtaccaccacctg
tgcctgcacagtgagagcaacatgcccctcaccatgcctgcgctcttcatcttcctggag
atgaaggactacgtacctggtgcttgggcagatctcactgtggccctcgccaaccccatt
aagttcttcagtgcccatgacaagaagtctgtgaagctcaaggaggccatgggaggtctg
cctgagaagcccttcccactggcgagtccagttgccagccaggtcaatggggcgttggcc
ccaacgagcaatgggtcaccagcagccagggccggggccagggaagaggctatgaaagaa
gctgcggagccgcggactgccagcctggaggagctccgggagctaaaggccgtcgtgaag
ctgcagcggcggcacgagaaggagctgcgggagttggagcggcgcggagcgcggcgctgg
gaggagctgctgcagcggggcgcggcgcagctggccgagctcgggccaccgggcgtggga
ggcgttggggcctgcaagctgggtccgggcaagggctctcgcaagaagaggagcctgccc
cgcgaggagagcgccggagctgcgccgggcgagggccctgagggcgtggacgggcgcgtg
cgggagctgaaggacaggctggaactagagctgctgcggcagggcgaggagcagtacgag
tgtgttctgaagcgcaaagagcagcacgcggccgagcaaatctccaaaatgatggagctg
gccagagagaaacaggcggcagagctgaaggccctgaaggagacgtcggagaacgacacc
aaagagatgaagaaaaagctggagacgaagagactggagcggatccagggcatgaccaaa
gtcaccgcagacaagatggcccaggagaggttgaagagagagattaacaactcccacatc
caggaagtagtgcaggtgatcaagcagatgacggagaacttggaggggcaccaggagaag
ctggaggagaagcaggcggcttgcctggaacagatacgggagatggaaaaacagttccag
aaggaggcgctggcagagtacgaggccaggatgaagggtctagaggcagaggtgaaggag
tcggtgagggcctgcctcaggacctgctttccctctgaggccaaggacaagcccgaaagg
gcctgcgagtgccccccagagctgtgtgagcaggacccactcgtagcaaaggcagatgcc
caggagagccgcctctga

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