KEGG   Pongo abelii (Sumatran orangutan): 100459809
Entry
100459809         CDS       T01416                                 
Symbol
TPH2
Name
(RefSeq) tryptophan 5-hydroxylase 2
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon00380  Tryptophan metabolism
pon00790  Folate biosynthesis
pon01100  Metabolic pathways
pon04726  Serotonergic synapse
Module
pon_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
KEGG Orthology (KO) [BR:pon00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    100459809 (TPH2)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    100459809 (TPH2)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    100459809 (TPH2)
Enzymes [BR:pon01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     100459809 (TPH2)
SSDB
Motif
Pfam: Biopterin_H ACT TH_ACT
Other DBs
NCBI-GeneID: 100459809
NCBI-ProteinID: XP_002823567
Ensembl: ENSPPYG00000004777
UniProt: H2NI28
Position
12:69865949..69965454
AA seq 490 aa
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKANSGKNDDKGNKGSSEIETAAD
SGKTAVVFSLKNEVGGLVKALRLFQEKHVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
NT seq 1473 nt   +upstreamnt  +downstreamnt
atgcagccagcaatgatgatgttttccagtaaatactgggcacggagagggttttccctg
gattcagcagtgcccgaagagcatcagctacttggcagctcaacactaaataaagctaac
tctggcaaaaatgacgacaaaggcaacaagggaagcagcgaaattgaaactgctgccgac
agtggcaagacagcagttgttttctccttgaaaaatgaagttggtggattggtaaaagca
ctgaggctctttcaggaaaaacatgtcaacatggttcatatcgaatccaggaaatctcgg
cgaagaagttctgaggttgaaatctttgtggactgtgagtgtgggaaaacagaattcaat
gagctcattcagttgctgaaatttcaaaccactattgtgacgctgaatcctccagagaac
atttggacagaggaagaagagctagaggatgtgccctggttccctcggaagatctctgag
ttagacaaatgctctcacagagttctcatgtatggttctgagcttgatgctgaccaccca
ggatttaaggacaatgtctatcgacagagaagaaagtattttgtggatgtggccatgggt
tataaatatggtcagcccattcccagggtggagtatactgaagaagaaactaaaacttgg
ggtgttgtattccgggagctctccaaactctatcccactcatgcttgccgagagtatttg
aaaaacttccctctgctgactaaatactgtggctacagagaggacaatgtgcctcaactc
gaagatgtctccatgtttctgaaagaaaggtctggcttcacggtgaggccagtggctgga
tacctgagcccacgagactttctggcaggactggcctacagagtgttccactgtacccag
tacatccggcatggctcagatcccctctacaccccggaaccagacacatgccatgaactc
ttgggacatgttccactacttgcggatcctaagtttgctcagttttcacaagaaataggt
ctggcgtctctgggagcgtcagatgaagatgttcagaaactagccacgtgctatttcttc
acaatcgagtttggcctttgcaagcaagaagggcaactgcgggcatatggagcaggactc
ctttcctccattggagaattaaagcatgccctttctgacaaggcatgtgtgaaagccttt
gacccaaagacaacttgcttacaggaatgccttatcaccaccttccaggaagcctacttt
gtttcagaaagttttgaagaagccaaagaaaagatgagggactttgcaaagtcaattaca
cgtcccttctcagtatacttcaatccctacacacagagtattgaaattctgaaagacacc
agaagtattgaaaatgtggtgcaggaccttcgcagcgacttgaacacagtgtgtgatgcc
ttaaacaaaatgaaccaatatctggggatttga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (29)   

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