KEGG   Pongo abelii (Sumatran orangutan): 100460060Help
Entry
100460060         CDS       T01416                                 

Gene name
PLCB3
Definition
phospholipase C, beta 3 (phosphatidylinositol-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pon00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100460060 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100460060 (PLCB3)
   04310 Wnt signaling pathway
    100460060 (PLCB3)
   04020 Calcium signaling pathway
    100460060 (PLCB3)
   04070 Phosphatidylinositol signaling system
    100460060 (PLCB3)
   04071 Sphingolipid signaling pathway
    100460060 (PLCB3)
   04022 cGMP - PKG signaling pathway
    100460060 (PLCB3)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100460060 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100460060 (PLCB3)
   04062 Chemokine signaling pathway
    100460060 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    100460060 (PLCB3)
   04912 GnRH signaling pathway
    100460060 (PLCB3)
   04915 Estrogen signaling pathway
    100460060 (PLCB3)
   04921 Oxytocin signaling pathway
    100460060 (PLCB3)
   04918 Thyroid hormone synthesis
    100460060 (PLCB3)
   04919 Thyroid hormone signaling pathway
    100460060 (PLCB3)
   04916 Melanogenesis
    100460060 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100460060 (PLCB3)
   04270 Vascular smooth muscle contraction
    100460060 (PLCB3)
  Digestive system
   04970 Salivary secretion
    100460060 (PLCB3)
   04971 Gastric acid secretion
    100460060 (PLCB3)
   04972 Pancreatic secretion
    100460060 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100460060 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    100460060 (PLCB3)
   04725 Cholinergic synapse
    100460060 (PLCB3)
   04728 Dopaminergic synapse
    100460060 (PLCB3)
   04726 Serotonergic synapse
    100460060 (PLCB3)
   04720 Long-term potentiation
    100460060 (PLCB3)
   04730 Long-term depression
    100460060 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    100460060 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100460060 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    100460060 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100460060 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100460060 (PLCB3)
   05016 Huntington's disease
    100460060 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    100460060 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    100460060 (PLCB3)
   05143 African trypanosomiasis
    100460060 (PLCB3)
Enzymes [BR:pon01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100460060 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
11
AA seq 1125 aa AA seqDB search
MEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFL
NFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKM
FSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGK
PYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSR
YLGGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGC
RCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDS
AKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGP
DSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSL
GEEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYVE
PVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSN
YMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEV
IVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDE
EPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPAL
LIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQEMCQDXQSQ
QLGSQPSSNPTPSPLDASHRRPLGPTTSPTSTSLSSPGQRDDLIASILSEVAPTPLDELR
GHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGATDV
EDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVVDANTT
QFKRLKEMNEREKKELQKILDRKRHNSISEAKTRDKHKKEAELTEINRRHITESVNSIRR
LEEAQKQRHDRLVAGQQQVLQQLAEEEPKMRRLRPGAISCVPGHS
NT seq 3378 nt NT seq  +upstreamnt  +downstreamnt
atggaggtggacacactggacatcagttccatcagggacacacggacaggccggtatgcc
cgcctgcccaaggaccccaagatccgggaagttctgggctttgggggtcccgatgcccgg
ctggaggagaagctgatgacggtggtgtctgggccagacccggtgaacacagtgttcttg
aacttcatggccgtgcaggatgacacagccaaggtctggtctgaggagctgttcaagctg
gctatgaacatcctggctcagaacgcctcccggaacaccttcctgcgcaaagcatacacg
aagctgaagctgcaggtgaaccaggatggtcggatccccgtcaagaacatcctgaagatg
ttctcagcagacaagaagcgggtggagactgcgctggaatcctgtggcctcaaattcaac
cggagtgagtccatccggcccgatgagttttccttggaaatctttgagcggttcctgaac
aagttgtgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaag
ccatacctgacgctggagcagctcatggacttcatcaaccagaagcaacgcgacccgaga
ctcaacgaagtgctgtacccgcccctgcggccctcccaggcccggctgctcatcgaaaag
tatgagcccaaccagcagtttctggagcgagaccagatgtccatggagggctttagccgc
tacctgggaggcgaggagaatggcatcctgcccctggaagccctggatctgagcgcagac
atgacccagccgctgagtgcctacttcatcaactcctcgcataacacctatctcactgcg
gggcagctggctgggacctcgtcggtggagatgtaccgccaggcactgctgtggggctgc
cgctgcgtggagctggacgtgtggaagggacggccgcccgaggaggaacccttcattacc
cacggcttcaccatgaccacagaggtgcctctgcgtgacgtgctggaggccattgccgag
accgccttcaagacctcaccctaccccgtcatcctctccttcgagaaccatgtggactcg
gcaaagcagcaggcaaagatggctgaatactgccgctccatctttggagatgcgctactc
atcgagcctctggacaagtacccgctggccccaggcgttcccctgcccagcccccaggac
ctgatgggccgtatcctggtgaagaacaagaagcggcaccgacccagcgcaggtggccca
gacagcgccgggcgcaagcggcccctggagcagagcaattctgccctgagcgagagctcc
gcggccaccgagccctcctccccgcagcttggctctcccagctctgacagctgcccaggc
ctgagcaacggggaggaggtggggcttgagaagcccagcctggagcctcagaagtctctg
ggcgaggagggcctgaaccggggcccctatgttctcggacctgctgaccgtgaggatgag
gaggaagatgaggaagaggaggaacagacagaccccaaaaagccaactacagatgagggc
acggccagcagcgaggtgaatgccactgaggagatgtccacgcttgtcaactacgtcgag
cctgtcaagttcaagtcctttgaggctgctcgaaagaggaacaaatgcttcgagatgtcg
tccttcgtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaa
tacaacaagcagcagctcagccgcatctaccccaagggcacccgcgtggactcctccaac
tacatgccccagctcttctggaacgtagggtgccagcttgttgcactcaacttccagacc
ctcgatgtggcgatgcagctcaacgcgggcgtttttgagtacaacgggcgcagcgggtac
ctgctcaagccggagttcatgcggcggccggacaagtccttcgaccccttcactgaggtc
atcgtggatggcatcgtggccaatgccttgcgggtcaaggtgatctcagggcagttcctg
tccgacaggaaggtgggcatctacgtggaggtggacatgtttggcctccctgttgacacg
cggcgcaagtaccgcacccggacctctcaggggaactcattcaaccccgtgtgggacgag
gagcccttcgacttccccaaggtggtgctgcccacgctggcttcacttcgcatcgcagcc
tttgaggaggggggtaaattcgtagggcaccggatcctgcctgtctctgccatccgctct
gggtaccactacgtctgcctgcggaacgaggccaaccaaccgctgtgcctgccggccctg
cttatctacaccgaagcctcggactacattcctgacgaccaccaggactacgcggaggcc
ctgatcaaccccattaagcacgtcagcctgatggaccagagggcccggcagctggccgcc
ctcattggggagagtgaggctcaggctggccaagagatgtgccaggacnaccagtctcag
cagctggggtctcagccgtcctcaaaccccacccctagcccactggatgcctcccaccgc
cggcccctcggccccaccacctcccctaccagcacctccctcagcagtccagggcagcgc
gacgatctcatcgctagcatcctctcagaggtggcccccaccccgctggatgagctccga
ggtcacaaggctctggtcaagctccggagccggcaagagcgagacctgcgggagctgcgc
aagaagcatcagcggaaggcagtcaccctcacccgccgcctgctggatggcctggctcag
gcacaggctgagggcaggtgccggctgcggccaggtgccctaggtggggccactgatgtg
gaggacacgaaggagggggaggacgaggcaaagcggtatcaggagttccagaacagacag
gtgcagagcctgctggagctgcgggaggcccaggtggacgcagaggcccagcggaggctg
gaacacctgagacaggctctgcagcggctcagggaggtcgtcgttgatgcaaacacaact
cagttcaagaggctgaaagagatgaacgagagggagaagaaggagctgcagaagatcctg
gacagaaagcgccataacagcatctcggaggccaagacgagggacaagcataagaaggag
gcggaactgacggagattaaccgtcggcacatcactgagtcagtcaactccatccgtcgg
ctggaggaggcccagaagcagcggcatgaccgtcttgtggctgggcagcagcaggtcctg
caacagctggcagaagaggagcccaagatgaggagactgaggcccggagccatctcttgt
gtgccaggccacagctaa

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