KEGG T01092: PAS_chr2-2

Pichia pastoris: PAS_chr2-2_0230

Entry

PAS_chr2-2_0230 CDS T01092

Definition

One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate

Orthology

K00021

hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]

Organism

ppa Pichia pastoris

Pathway

ppa00900	Terpenoid backbone biosynthesis
ppa01100	Metabolic pathways
ppa01110	Biosynthesis of secondary metabolites

Module

ppa_M00095

C5 isoprenoid biosynthesis, mevalonate pathway

Class

Metabolism; Metabolism of terpenoids and polyketides; Terpenoid backbone biosynthesis [PATH:ppa00900]

SSDB

Motif

Pfam:

HMG-CoA_red HPIH Sterol-sensing

Other DBs

NCBI-GI:

254569712

NCBI-GeneID:

8198637

UniProt:

C4R2G2

Position

2:complement(1957199..1960159)

AA seq 986 aa
MLTGLSKICAHRPIHTIVVTALLVSLAYLTIVEEYTSRSSLSNPFISFYHPPGNSDYQNW
IPVDDSVKLKSKSAQHLSVCALKFKRVNGHQIPDLAGSFQSADPTEIFVVQDFDKSFDYF
DSISTIEGKDGIQWKVRHPNRLGRYSEYFRSVFSKTLRLVQGAEPFDIVLIAFAYVAMWY
TFLQLYYEMKTKANSNFWLTFGSLLSSGCAFVFALAVTVKVYGIKVPLTSLTEGVPFLVA
TIGFKHKVAFTVPILQASRSKKAKEIPDTIISVIEQTTGWPLIKDHLIMISAFLACSFYA
PRMEGLKNFCILSANILTFDLIMIFTFFTAVLSLKAQINKVHETTALQQVLEEDGIAEDV
AERIAASNRNMFSRSTSVVSFKVIMIAGFLGFHLFVLGTSWLYDSDVSSSSIFGKSNVSA
LSKAAAKHIPIGSEGTIVTIMPTRVYMPVDLLLKLEDDFLNIFSKISASITDPLISKLLF
IITGISATINVYLLNAARFHSSREIAVSTIAKPQTPDVVPTVEPLPNENDTSIRPLEEMV
SLLKEGKTRELNNDEVSSLVVQGKLPLYALEKQLVDKTRAVIVRRKAIASLADAPVLRTE
KLPYKDYDYDRVFGACCENVIGFMPLPVGVAGPLIIDGKPYHIPMATTEGCLVASTMRGC
KAINSGGGVETVLTADGMTRGPCVSFPSLSRAGAAKMWLDSEEGQKTIKGAFNSTSRFAR
LQHVKTTLAGTLLFIRFKTTTGDAMGMNMISKGVEYSLKFMSEECDWPDMEVISVSGNYC
TDKKVAAINWIEGRGKSVVAEARIPADVVRSVLKSDVEALVELNVSKNLIGSAMAGSIGG
FNAQAANLVTAVYLATGQDPAQNVESSNCITLMNKLPNGDLQISVSMPSIEVGTIGGGTV
LEPQGSMLELLGVKGPHPTNPGANSRQLAKIVASAVLAAELSLCSALAAGHLVQSHMTHN
RKQAPVKEVNGTAARLAEQSKICIKS

NT seq 2961 nt +upstreamnt +downstreamnt
atgcttactgggttgtccaagatatgtgcgcatagaccaatccataccatagtggtgacc
gctctcttagtttccttagcatacctaaccattgtggaggagtacacatcgagatcttca
ttatccaatccttttatatcgttttaccacccaccaggaaacagtgattaccaaaattgg
attccagtggatgactctgtgaagctcaaaagcaagtcagcccagcatctctctgtatgc
gctttgaagtttaaaagggttaatggacatcagattcccgatctggcaggaagttttcag
agcgcagacccaactgaaatatttgtcgttcaggattttgacaaatcatttgactatttt
gattcaatttcaaccattgagggtaaggatggcatccaatggaaagtcagacaccccaat
aggttgggacgttattctgagtacttcagatctgttttttcaaaaactttgagactggtt
cagggtgctgaaccattcgacattgtgcttattgcttttgcttacgttgctatgtggtac
acatttttgcagctctattatgaaatgaaaacaaaggccaactctaacttttggctgact
ttcggctctctgctgtcttcaggttgtgcatttgtgtttgcattggccgtcactgtaaaa
gtatacggtatcaaggttccactcacatctttaactgaaggtgtcccatttttggtagct
accattggtttcaaacacaaagttgcattcactgttcctattctccaagcttcccgttca
aaaaaagccaaagaaattcctgacaccattatttcagtgattgaacaaaccacagggtgg
cctctgattaaggatcatctcattatgatttccgccttcttagcatgttctttttatgcc
ccccgtatggaaggactcaaaaacttttgcattctctccgctaatatcttaacgtttgac
cttataatgattttcacattttttaccgctgtattatctttaaaagctcagattaataag
gttcacgaaacaactgctttgcagcaagttctggaggaagatggaattgctgaagatgtt
gctgaacgcattgctgcttcaaaccgaaatatgttttcccgtagtaccagcgtcgtcagc
ttcaaagtgataatgatcgctgggttccttggattccatttatttgtgttgggaacttca
tggctctatgactctgacgtttcaagctcttctatatttggtaagagcaatgtatctgcc
ttatccaaagctgctgccaaacatattcctattggatccgaaggaactattgtgaccatt
atgcctacgagggtttacatgcctgttgatttacttctaaagttggaagatgattttctg
aacattttttccaagatatcggctagcataactgatcctttgattagcaaacttcttttc
ataattaccggaataagtgccacaatcaacgtttacttgttgaatgctgctcgattccac
tcgtctagagaaattgctgtctctacaattgcaaagcctcaaacgccagacgttgttccc
acagtagaaccgcttccaaatgaaaatgacacaagcattcgaccattggaggagatggtt
tcattgctgaaggaaggtaaaacacgagagctgaacaatgatgaggtatcatctctcgtt
gttcaaggaaaacttcccttgtacgccctagaaaaacaacttgttgataagacccgcgca
gttattgtaagaaggaaggcaattgcttccttagcagatgctccggtcttgagaaccgaa
aagctgccttacaaagattatgattatgaccgtgtatttggcgcttgttgtgagaatgtt
atcggattcatgcccttaccagtcggcgttgctggtcccttgatcattgacggtaaacct
tatcacattcccatggctactactgaaggctgcttagtagcctcaaccatgagaggttgt
aaagctatcaattctggaggcggtgtagaaactgttctgacagccgacggaatgacaaga
ggaccatgcgtttctttcccatctctttctcgtgcaggtgcagctaagatgtggctagat
agtgaagaagggcaaaagaccattaagggtgcgtttaactccacctctagatttgcccgt
ttgcagcatgttaagacaacccttgctggtacattattgttcatccgattcaagactact
actggtgatgcgatgggtatgaacatgatttctaagggtgtggagtattcactaaagttt
atgtcggaagaatgtgactggcctgacatggaagttatttctgtttcaggtaattactgt
acagacaaaaaagttgctgcaatcaactggatcgaaggtcgtggtaagtctgtcgttgct
gaagctcgtattccagccgatgttgtcagaagcgttctgaagtccgatgttgaggcattg
gtagaattgaatgttagcaagaacttgattggatccgcaatggcaggatcaattggtggt
ttcaacgcacaagctgccaatctagttacagcagtatacttagctacaggacaggatcca
gcccagaatgtcgaaagttccaactgtattaccttgatgaacaagctcccaaatggagat
ttacaaatttcagtctctatgccatctatcgaagttggaaccattggtggaggaaccgtt
ttggaacctcaaggatcaatgttggaactattaggagttaaaggtcctcacccaactaat
ccaggtgcaaactcaaggcagttggctaagatcgttgcttctgctgtcttggctgcagag
ctgtccttgtgctctgcccttgcagctggtcacttagtccaaagtcatatgacccataac
agaaagcaagctccagtcaaggaggtaaacggcactgccgctaggctagcggaacaatct
aagatttgcattaaatcttga

All links

Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (23)   

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