KEGG   Pan paniscus (bonobo): 100971596Help
Entry
100971596         CDS       T02283                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
pps  Pan paniscus (bonobo)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    100971596 (IRS1)
   04022 cGMP - PKG signaling pathway
    100971596 (IRS1)
   04151 PI3K-Akt signaling pathway
    100971596 (IRS1)
   04152 AMPK signaling pathway
    100971596 (IRS1)
   04150 mTOR signaling pathway
    100971596 (IRS1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100971596 (IRS1)
   04920 Adipocytokine signaling pathway
    100971596 (IRS1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100971596 (IRS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100971596 (IRS1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    100971596 (IRS1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100971596 (IRS1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100971596 (IRS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1242 aa AA seqDB search
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVES
SGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP
EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH
LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQPLLHPPEPKSPGEYVNIEF
GSDQPGYLSGPVASHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVE
MGRLGPVPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAA
EEVSLPRATMVAASSSSAVSASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNR
NQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGATVGGGGGSSSSSSEDVKR
HSSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQ
PPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ
NT seq 3729 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag
gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac
cacgacggagctgcggccctcggggcgggaggtggtgggggcagctgcagcggcagctcc
ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc
aaagaggtctggcaagtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt
ggtatctaccgcctttgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcagcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggaaaacttc
ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg
gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg
agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc
agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc
cgccgatcgcgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag
ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc
tcggtggacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg
ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccggcttcc
cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat
ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc
agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccggagt
tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag
gagctaagcaactatatctgcatgggtggtaaggggccctccaccctgaccgcccccaac
ggtcactacattttgtctcggggtggcaatggccaccgctgcaccccaggaacaggcttg
ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg
ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg
tcccagtcctcagtggcttccattgaggagtacacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccac
tcctacccagaggagggtctggaaatgcaccccttggagcgtcggggggggcaccaccgc
ccagacagctccaccctccacacggatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccagcggccgaaagggcagtggagactatatgcccatgagccccaagagcgta
tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtcccccagcggcggctgctctcctgacattggaggtggccccagc
agcagcagcagcagcagcaatgccgtcccttccgggaccagctatggaaagctgtggaca
aacggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagc
agcggtggtaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggac
tccaacaccagcagcccctccgactgctactacggccctgaggacccccagcacaagcca
gtcctctcctactactcattgccaagatcctttaagcacacccagcgccccggggagccg
gaggagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctat
gctgcaacagcggatgattcttcctcttccaccagcagcgacagcctgggtgggggatac
tgcggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccat
ctgcctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgagg
ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcag
cagcccttgctgcaccctccagagcccaagagcccgggggaatatgtcaatattgaattt
gggagtgatcagcctggctacttgtctggcccggtggcttcccacagctcaccttctgtc
aggtgtccatcccagctccagccagctcccagagaggaagagactggcactgaggagtac
atgaagatggacctggggccgggccggagggcagcttggcaggagagcactggggtcgag
atgggcagactgggccctgtacctcccggggctgctagcatttgcaggcctacccgggca
gtgcccagcagccggggtgactacatgaccatgcagatgagttgtccccgtcagagctat
gtggacacctcgccagctgcccctgtaagctatgctgacatgcggacaggcattgctgca
gaggaggtgagcctgcccagggccaccatggttgctgcctcctcatcctcagcagtctct
gcttccccgactgggcctcaaggggcagcagagctggctgcccactcgtccctgctgggg
ggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagtcctaaccgc
aaccagagtgccaaagtgatccgtgcagacccacaagggtgccggcggaggcatagctcc
gagactttctcctcaacacccagtgccacccgggtgggcaacacagtgccctttggagcg
ggggcaacagtagggggcggtggcggtagcagcagcagcagcagcgaggatgtgaaacgc
cacagctctgcttcctttgagaatgtgtggctgaggcctggggagcttgggggagccccc
aaggagccagcccaactgtgtggggctgctgggggtttggagaatggtcttaactacata
gacctggatttggtcaaggacttcaaacagtgccctcaggagtgcacccctgaaccgcag
cctcccccacccccaccccctcatcaacccctgggcagcggtgagagcagctccacccgc
cgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggac
cgtcagtag

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