KEGG   Pan paniscus (bonobo): 100980038Help
Entry
100980038         CDS       T02283                                 

Gene name
SOS2
Definition
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
  KO
K03099  son of sevenless
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps04010  MAPK signaling pathway
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04062  Chemokine signaling pathway
pps04068  FoxO signaling pathway
pps04072  Phospholipase D signaling pathway
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04510  Focal adhesion
pps04540  Gap junction
pps04630  Jak-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04714  Thermogenesis
pps04722  Neurotrophin signaling pathway
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04912  GnRH signaling pathway
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04926  Relaxin signaling pathway
pps05034  Alcoholism
pps05160  Hepatitis C
pps05165  Human papillomavirus infection
pps05200  Pathways in cancer
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100980038 (SOS2)
   04010 MAPK signaling pathway
    100980038 (SOS2)
   04012 ErbB signaling pathway
    100980038 (SOS2)
   04630 Jak-STAT signaling pathway
    100980038 (SOS2)
   04068 FoxO signaling pathway
    100980038 (SOS2)
   04072 Phospholipase D signaling pathway
    100980038 (SOS2)
   04151 PI3K-Akt signaling pathway
    100980038 (SOS2)
   04150 mTOR signaling pathway
    100980038 (SOS2)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    100980038 (SOS2)
   04540 Gap junction
    100980038 (SOS2)
  Cell motility
   04810 Regulation of actin cytoskeleton
    100980038 (SOS2)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100980038 (SOS2)
   04660 T cell receptor signaling pathway
    100980038 (SOS2)
   04662 B cell receptor signaling pathway
    100980038 (SOS2)
   04664 Fc epsilon RI signaling pathway
    100980038 (SOS2)
   04062 Chemokine signaling pathway
    100980038 (SOS2)
  Endocrine system
   04910 Insulin signaling pathway
    100980038 (SOS2)
   04912 GnRH signaling pathway
    100980038 (SOS2)
   04915 Estrogen signaling pathway
    100980038 (SOS2)
   04917 Prolactin signaling pathway
    100980038 (SOS2)
   04926 Relaxin signaling pathway
    100980038 (SOS2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100980038 (SOS2)
  Environmental adaptation
   04714 Thermogenesis
    100980038 (SOS2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100980038 (SOS2)
   05231 Choline metabolism in cancer
    100980038 (SOS2)
   05206 MicroRNAs in cancer
    100980038 (SOS2)
   05205 Proteoglycans in cancer
    100980038 (SOS2)
   05210 Colorectal cancer
    100980038 (SOS2)
   05225 Hepatocellular carcinoma
    100980038 (SOS2)
   05226 Gastric cancer
    100980038 (SOS2)
   05214 Glioma
    100980038 (SOS2)
   05221 Acute myeloid leukemia
    100980038 (SOS2)
   05220 Chronic myeloid leukemia
    100980038 (SOS2)
   05211 Renal cell carcinoma
    100980038 (SOS2)
   05215 Prostate cancer
    100980038 (SOS2)
   05213 Endometrial cancer
    100980038 (SOS2)
   05224 Breast cancer
    100980038 (SOS2)
   05223 Non-small cell lung cancer
    100980038 (SOS2)
  Substance dependence
   05034 Alcoholism
    100980038 (SOS2)
  Infectious diseases
   05160 Hepatitis C
    100980038 (SOS2)
   05165 Human papillomavirus infection
    100980038 (SOS2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100980038 (SOS2)
   01522 Endocrine resistance
    100980038 (SOS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RasGEF RasGEF_N RhoGEF PH Histone IQ_SEC7_PH PH_13
Motif
Other DBs
NCBI-GeneID: 100980038
NCBI-ProteinID: XP_008955357
Position
14
AA seq 871 aa AA seqDB search
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCEYKHAFELVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLA
IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIRRKKQAQANGISHNITFESPPPPIEWHISKPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
EAVELSQDHFKKYLVKLKSINPPCVPFLEYI
NT seq 2616 nt NT seq  +upstreamnt  +downstreamnt
atggcccagccaaggactgttcaagatgtagaggagcgagttcagaagacctttcctcac
ccaattgataaatgggccattgctgatgcacaatctgctatagaaaaacgaaaacgaaga
aatcctcttttactgcctgtggacaaaatccatccttcgttgaaggaagtattagggtac
aaagtggactaccatgtgtccctatatattgtggctgtactagagtatatctcagctgat
attttaaaattggctggtaattatgtttttaatatccggcattatgaaatatctcagcag
gacattaaagtgtcaatgtgtgcggataaggttttgatggacatgtttgatcaggatgac
ataggtttggtttctctctgtgaagatgaacctagttcttctggtgaattaaactactat
gatcttgtcagaactgaaatcgcagaagaaagacagtatctacgggaattaaatatgatc
ataaaagtgtttcgagaagcctttctttctgatagaaagctgtttaaaccttctgatatc
gaaaagatttttagtaacatttcagatatacatgaattgactgtgaaacttttaggtttg
attgaagacacagttgaaatgactgatgaaagcagtcctcatcccttagctggcagctgt
tttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaggacatt
ctttcaccagagtttcatgaacatttcaataaattaatggccagacctgcagttgctcta
cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgtctt
atgctggtgccagtgtatcactgttggcactactttgagttactaaagcaattgaaagca
tgtagtgaagaacaagaagacagagaatgtttgaaccaagctattactgctctcatgaat
ctccaaggtagcatggaccgaatttacaagcagtattcacctagacgtcgacctggagat
cctgtttgccctttttatagtcaccaattaagaagcaaacacctggctatcaaaaaaatg
aatgaaattcagaaaaatattgatggatgggaaggcaaagatattggacagtgttgtaat
gaattcattatggagggaccattgacaagaatcggtgccaaacatgaacggcatattttt
ctgtttgatggcttaatgatcagttgtaaacctaatcatggccagactcggcttccaggt
tacagtagtgcagaatacaggttaaaagaaaaatttgtcatgaggaaaatacaaatttgt
gataaagaagatacttgtgagtacaagcatgcatttgaattagtatccaaagatgagaac
agcataatatttgccgctaagtctgctgaagaaaaaaacaactggatggcagcccttatt
tctcttcattatcgtagtactctagatcgaatgttagattcagtattattgaaagaagaa
aatgagcaaccactgagattaccaagtcctgaagtatatcgttttgtagtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggcatccccattattaaa
ggaggaactgtagtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat
tttgttcgtacttttcttaccacgtatcgttcattttgtaaaccacaggaattgctgagc
ttactgattgaacggtttgaaattccagagccagaacctactgatgcagacaaattggca
atagagaaaggcgagcagccaatcagtgcagaccttaaaagatttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtatttcggcattgggttgaacatcatttttat
gactttgaaagagacttggaattgcttgaaagactagaatccttcatttcaagtgtaaga
gggaaagctatgaaaaaatgggtagagtcaatcgctaagatcatcaggaggaagaagcaa
gctcaggcaaatggaataagccataatattacctttgaaagtccacctccaccaattgaa
tggcatatcagcaaaccaggacagtttgaaacatttgatctcatgacacttcatccaata
gaaattgcacgtcagctgacacttttggagtctgatctctacaggaaagttcaaccgtct
gaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccataccacaaatctcaccctctggtttgaaaaatgcattgtggaagca
gaaaattttgaagaacgggtggcagtactaagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggcgtattggagatagtcagtgcagtaaattcagtatca
gtatacagactagaccatacctttgaggcattgcaggaaagaaaaaggaaaattttggac
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaagtcaatc
aatccaccttgtgtgccttttttggaatatatttaa

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