KEGG   Pan paniscus (bonobo): 100990828Help
Entry
100990828         CDS       T02283                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
pps  Pan paniscus (bonobo)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100990828 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100990828 (PIK3CA)
   04015 Rap1 signaling pathway
    100990828 (PIK3CA)
   04012 ErbB signaling pathway
    100990828 (PIK3CA)
   04370 VEGF signaling pathway
    100990828 (PIK3CA)
   04630 Jak-STAT signaling pathway
    100990828 (PIK3CA)
   04668 TNF signaling pathway
    100990828 (PIK3CA)
   04066 HIF-1 signaling pathway
    100990828 (PIK3CA)
   04068 FoxO signaling pathway
    100990828 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100990828 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    100990828 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100990828 (PIK3CA)
   04152 AMPK signaling pathway
    100990828 (PIK3CA)
   04150 mTOR signaling pathway
    100990828 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100990828 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    100990828 (PIK3CA)
  Cell communication
   04510 Focal adhesion
    100990828 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100990828 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100990828 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100990828 (PIK3CA)
   04660 T cell receptor signaling pathway
    100990828 (PIK3CA)
   04662 B cell receptor signaling pathway
    100990828 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100990828 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100990828 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100990828 (PIK3CA)
   04062 Chemokine signaling pathway
    100990828 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    100990828 (PIK3CA)
   04915 Estrogen signaling pathway
    100990828 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100990828 (PIK3CA)
   04917 Prolactin signaling pathway
    100990828 (PIK3CA)
   04921 Oxytocin signaling pathway
    100990828 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100990828 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100990828 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100990828 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100990828 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    100990828 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100990828 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100990828 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    100990828 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100990828 (PIK3CA)
   05205 Proteoglycans in cancer
    100990828 (PIK3CA)
   05203 Viral carcinogenesis
    100990828 (PIK3CA)
   05210 Colorectal cancer
    100990828 (PIK3CA)
   05212 Pancreatic cancer
    100990828 (PIK3CA)
   05214 Glioma
    100990828 (PIK3CA)
   05221 Acute myeloid leukemia
    100990828 (PIK3CA)
   05220 Chronic myeloid leukemia
    100990828 (PIK3CA)
   05218 Melanoma
    100990828 (PIK3CA)
   05211 Renal cell carcinoma
    100990828 (PIK3CA)
   05215 Prostate cancer
    100990828 (PIK3CA)
   05213 Endometrial cancer
    100990828 (PIK3CA)
   05222 Small cell lung cancer
    100990828 (PIK3CA)
   05223 Non-small cell lung cancer
    100990828 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100990828 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100990828 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100990828 (PIK3CA)
   05166 HTLV-I infection
    100990828 (PIK3CA)
   05162 Measles
    100990828 (PIK3CA)
   05164 Influenza A
    100990828 (PIK3CA)
   05161 Hepatitis B
    100990828 (PIK3CA)
   05160 Hepatitis C
    100990828 (PIK3CA)
   05169 Epstein-Barr virus infection
    100990828 (PIK3CA)
   05146 Amoebiasis
    100990828 (PIK3CA)
   05145 Toxoplasmosis
    100990828 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    100990828 (PIK3CA)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100990828 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1061 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKNSSKAISTRDPL
SEITEQEKDFLWSHRWLIHNYLSPLNMIYCLSHTQMYCLVKDWPPIKPEQAMELLDCNYP
DPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFF
FWHLKSEMHNKTVSQRFGLLLESYCRACGVYLKHLNRQVEAMEKLINLTDILKQEKKDET
QKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPD
IMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGL
IEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRPCAGYCVA
TFISGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKG
AQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLA
LDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3186 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaagaacagctcaaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagccacagatggctcattcacaac
tatctttcccctttaaatatgatttattgtctttctcatacacagatgtattgcttggta
aaagattggcctccaatcaaacctgaacaggctatggaacttctggactgtaattaccca
gatcctatggttcgaggttttgctgttcggtgcttggaaaaatatttaacagatgacaaa
ctttctcagtatttaattcagctagtacaggtcctaaaatatgaacaatatttggataac
ttgcttgtgagatttttactgaagaaagcattgactaatcaaaggattgggcactttttc
ttttggcatttaaaatctgagatgcacaataaaacagttagccagaggtttggcctgctt
ttggagtcctattgtcgtgcatgtggggtgtatttgaagcacctgaataggcaagtcgag
gcaatggaaaagctcattaacttaactgacattctcaaacaggagaagaaggatgaaaca
caaaaggtacagatgaagtttttagttgagcaaatgaggcgaccagatttcatggatgct
ctacagggctttctgtctcctctaaaccctgctcatcaactaggaaacctcaggcttgaa
gagtgtcgaattatgtcctctgcaaaaaggccactgtggttgaattgggagaacccagac
atcatgtcagagttactgtttcagaacaatgagatcatctttaaaaatggggatgattta
cggcaagatatgctaacacttcaaattattcgtattatggaaaatatctggcaaaatcaa
ggtcttgatcttcgaatgttaccttatggttgtctgtcaatcggtgactgtgtgggactt
attgaggtggtgcgaaattctcacactattatgcaaattcagtgcaaaggcggcttgaaa
ggtgcactgcagttcaacagccacacactacatcagtggctcaaagacaagaacaaagga
gaaatatatgatgcagccattgacctgtttacacgtccatgtgctggatactgtgtagct
accttcatttcgggaattggagatcgtcacaatagtaacatcatggtgaaagacgatgga
caactgtttcatatagattttggacactttttggatcacaagaagaaaaaatttggttat
aaacgagaacgtgtgccatttgttttgacacaggatttcttaatagtgattagtaaagga
gcccaagaatgcacaaagacaagagaatttgagaggtttcaggagatgtgttacaaggct
tatctagctattcgacagcatgccaatctcttcataaatcttttctcaatgatgcttggc
tctggaatgccagaactacaatcttttgatgacattgcatacattcgaaagaccctagcc
ttagataaaactgagcaagaggctttggagtatttcatgaaacaaatgaatgatgcacat
catggtggctggacaacaaaaatggattggatcttccacacaattaaacagcatgcattg
aactga

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