KEGG   Panthera tigris altaica (Amur tiger): 102967156Help
Entry
102967156         CDS       T02988                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ptg00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102967156 (INSR)
   04015 Rap1 signaling pathway
    102967156 (INSR)
   04010 MAPK signaling pathway
    102967156 (INSR)
   04066 HIF-1 signaling pathway
    102967156 (INSR)
   04068 FoxO signaling pathway
    102967156 (INSR)
   04072 Phospholipase D signaling pathway
    102967156 (INSR)
   04022 cGMP - PKG signaling pathway
    102967156 (INSR)
   04151 PI3K-Akt signaling pathway
    102967156 (INSR)
   04152 AMPK signaling pathway
    102967156 (INSR)
   04150 mTOR signaling pathway
    102967156 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    102967156 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    102967156 (INSR)
   04923 Regulation of lipolysis in adipocyte
    102967156 (INSR)
   04913 Ovarian Steroidogenesis
    102967156 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102967156 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    102967156 (INSR)
   04213 Longevity regulating pathway - multiple species
    102967156 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102967156 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102967156 (INSR)
   04931 Insulin resistance
    102967156 (INSR)
Enzymes [BR:ptg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     102967156 (INSR)
Protein kinases [BR:ptg01001]
 Tyrosine protein kinases
  InsR family [OT]
   102967156 (INSR)
Enzyme-linked receptors [BR:ptg01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   102967156 (INSR)
Cytokine receptors [BR:ptg04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   102967156 (INSR)
CD molecules [BR:ptg04090]
 Proteins
  102967156 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Un
AA seq 1344 aa AA seqDB search
MDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLVMITDYLLLFRVYGLE
SLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLAT
IDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK
VCPTICKSHGCTADGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD
WRCVNFSFCRDLHNKCKNSRRQGCHQYVIHNNRCIPECPSGYTMNSSNLMCTPCLGPCPK
VCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKI
RRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHY
NPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWE
PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG
WLMRGLKPWTQYAVFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKH
NQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSFSSPGAEDSRP
SRKRRALADAGNVTAAVPTVPGFPNTSSSVPTSPEEHKPFEKVVNKESLVISGLRHFTGY
RIELQACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPN
GLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTE
ATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE
YLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKT
VNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMVHGDLKSYLRSL
RPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF
GMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQ
GLSNEQVLKFVMDGGYLDQPDNCPERVTDLMHMCWQFNPKMRPTFLEIVDLLKDDLHPSF
PEVSFFHSEENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDGVSSLGLKRNYEDH
IPYTHMNGGKKNGRILTLPRSNPS
NT seq 4035 nt NT seq  +upstreamnt  +downstreamnt
atggatatccggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaa
ggtcatttgcagatactgctcatgttcaaaacgcggcccgaggacttccgagacctcagt
ttccccaaactcgtcatgatcactgattacttgctgctcttccgggtgtatgggctggag
agcctgaaggacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaac
tacgcgctggtcatcttcgagatggtgcacctgaaggagcttggcctctacagcttgatg
aacattacccggggctccgtccgcatcgagaagaacaatgagctgtgctacctggccacc
atcgactggtcacgcatcctggattcggtggaggataattacattgtgttgaacaaagac
gacaacgaggagtgtggggacatttgtccaggcaccgcaaagggcaagaccaactgccct
gccactgtcatcaacgggcagtttgtggagcgatgttggacacacagccattgccagaaa
gtttgtccgaccatctgcaagtcgcacggctgcacggccgacggcctctgctgccacagc
gagtgtctgggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaac
ttctacctggacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagac
tggcgctgcgtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccgg
agacagggttgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcg
gggtacacgatgaattccagcaacctgatgtgtactccctgcctgggcccctgtcccaag
gtctgccacatcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctc
cgaggctgcaccgtcgtcaacggaagcctaatcatcaacattcgagggggcaacaacctg
gcagctgagctggaggccaacctcggactcattgaagaaatttctgggtacctgaagatc
cgaaggtcctatgctcttgtgtcactttcctttttccggaagttacggctgattcgggga
gagaccttggaaatcgggaactactctttctatgccttggacaaccagaacctgaggcag
ctatgggactggagcaaacacaacctcaccatcactcaggggaaactcttcttccactat
aatcccaaactctgcttgtcggaaattcacaagatggaggaggtttcaggaaccaagggg
cgccaggagcggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaat
gaactacttaaattttcttacattcggacatcttacgacaagatcttgctgaaatgggag
ccgtactggccccctgacttccgagacctcctgggcttcatgctcttctacaaagaggcc
ccttatcagaatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacg
gtggtggacattgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccaggg
tggctgatgcggggtctgaagccctggacccagtatgctgtctttgtcaagaccttggtc
accttttctgatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagacc
gatgccaccaacccttccgtccccctggatcctatctcggtttcgaattcctcctctcag
atcattctgaagtggaagcctccctcggaccccaatggcaacatcacgcactacctggtg
ttctgggagaggcaggcggaggacagtgagctgtatgagttggattattgcctcaaaggg
ttgaagctgccttcccggacctggtccccgccgttcgagtccgagggctcccagaagcac
aatcagagtgagtacgaggagtccgctggcgaatgctgctcgtgtcccaagaccgactct
cagatcctgaaggagctggaggagtcttctttcaggaagacgttcgaggattacctgcac
aatgtggttttcgtgcccagaaaatccttttcaagccctggtgctgaggacagtaggccg
tcgcggaagcgcagggccctcgccgacgctgggaacgtgaccgccgccgtgcccacggtg
cctggtttccccaacacttccagcagcgtgcccacgagcccggaagagcacaagcccttc
gagaaggtggtgaacaaagagtctctggtcatctccggcctgcgtcacttcaccggctac
cgcatcgagctgcaggcttgcaaccaagatgcccccgaggagaggtgcagcgtggccgcc
tacgtcagcgccaggaccatgcccgaagccaaggcagacgacattgttggccctgtgacc
catgaaatcttcgagaacaacgtggttcacttgatgtggcaagagcctaaagaacccaat
ggattgatcgtgctgtatgaagtgagttaccgacggtatggtgatgaggagctgcacctc
tgtgtctcccgtagacactttgctctggagcggggctgcaggctgcgagggctgccgccg
gggaattacagtgtgcgagttcgggccacctccctggcgggcaacggctcctggacagaa
gccacttatttctatgtgacagactatttagatgtcccatcgaacattgcaaaaattatc
atcgggcctctcatctttgtctttctcttcagtgttgtgattggaagtatttatctattc
ctgagaaagaggcagccggatgggccactggggccgctgtatgcttcttcaaaccctgag
tacctcagtgccagtgatgtgtttccctgctctgtgtatgtgccggacgagtgggaggtg
cctcgggagaagatcactctcctgcgcgagctggggcagggctccttcggcatggtgtac
gagggcaatgccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacg
gtcaacgagtccgccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatg
aagggcttcacttgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccg
acgctggtggtgatggagctgatggttcacggagacctgaagagctacctccgctccctg
cggccggaggctgagaataaccctggccgccctccccctactctgcaagagatgattcag
atggcggcggagatcgccgacgggatggcgtacctgaatgccaagaagtttgtgcaccgg
gatctcgcagctcgaaattgcatggtggcccacgacttcaccgtcaaaattggagacttc
ggaatgaccagagacatctatgaaacggattactaccggaaaggaggcaagggtctgctc
cccgtgcggtggatggcaccggaatccctgaaggacggggtcttcaccacttcttctgac
atgtggtcctttggtgtggtcctttgggaaatcaccagcttggcggaacaaccttaccaa
ggcctgtctaatgaacaggtgttgaaatttgtcatggacggaggatatttggaccaacct
gacaactgtccggagagagtcaccgacctgatgcacatgtgctggcagttcaatcccaag
atgcggcccaccttcctggagatcgttgacctgctcaaagacgacctgcaccccagcttt
ccggaagtctccttcttccacagcgaggagaacaaggcgcctgagagtgaggagttggaa
atggagtttgaggacatggagagtgtccccctggatcgggcctcacactcacagagggaa
gaggccgggggccgggatggagtgtcctcgctgggcctcaagcggaactacgaggaccac
atcccctacacccacatgaacgggggcaagaaaaacggacggattctgaccctgccgagg
tcgaatccttcctaa

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