KEGG   Pan troglodytes (chimpanzee): 450188Help
Entry
450188            CDS       T01005                                 

Gene name
MAP2K1, MEK
Definition
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)
Orthology
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Dorso-ventral axis formation
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Class
Environmental Information Processing; Signal transduction; Ras signaling pathway [PATH:ptr04014]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:ptr04015]
Environmental Information Processing; Signal transduction; MAPK signaling pathway [PATH:ptr04010]
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:ptr04012]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:ptr04370]
Environmental Information Processing; Signal transduction; TNF signaling pathway [PATH:ptr04668]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:ptr04066]
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:ptr04068]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:ptr04151]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:ptr04810]
Cellular Processes; Cell growth and death; Oocyte meiosis [PATH:ptr04114]
Cellular Processes; Cell communication; Focal adhesion [PATH:ptr04510]
Cellular Processes; Cell communication; Gap junction [PATH:ptr04540]
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:ptr04620]
Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:ptr04650]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:ptr04660]
Organismal Systems; Immune system; B cell receptor signaling pathway [PATH:ptr04662]
Organismal Systems; Immune system; Fc epsilon RI signaling pathway [PATH:ptr04664]
Organismal Systems; Immune system; Fc gamma R-mediated phagocytosis [PATH:ptr04666]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:ptr04062]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:ptr04910]
Organismal Systems; Endocrine system; GnRH signaling pathway [PATH:ptr04912]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:ptr04915]
Organismal Systems; Endocrine system; Progesterone-mediated oocyte maturation [PATH:ptr04914]
Organismal Systems; Endocrine system; Prolactin signaling pathway [PATH:ptr04917]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:ptr04921]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:ptr04919]
Organismal Systems; Endocrine system; Melanogenesis [PATH:ptr04916]
Organismal Systems; Circulatory system; Vascular smooth muscle contraction [PATH:ptr04270]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:ptr04725]
Organismal Systems; Nervous system; Serotonergic synapse [PATH:ptr04726]
Organismal Systems; Nervous system; Long-term potentiation [PATH:ptr04720]
Organismal Systems; Nervous system; Long-term depression [PATH:ptr04730]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:ptr04722]
Organismal Systems; Development; Dorso-ventral axis formation [PATH:ptr04320]
Organismal Systems; Development; Osteoclast differentiation [PATH:ptr04380]
Human Diseases; Cancers; Pathways in cancer [PATH:ptr05200]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:ptr05206]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:ptr05205]
Human Diseases; Cancers; Colorectal cancer [PATH:ptr05210]
Human Diseases; Cancers; Pancreatic cancer [PATH:ptr05212]
Human Diseases; Cancers; Glioma [PATH:ptr05214]
Human Diseases; Cancers; Thyroid cancer [PATH:ptr05216]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:ptr05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:ptr05220]
Human Diseases; Cancers; Melanoma [PATH:ptr05218]
Human Diseases; Cancers; Renal cell carcinoma [PATH:ptr05211]
Human Diseases; Cancers; Bladder cancer [PATH:ptr05219]
Human Diseases; Cancers; Prostate cancer [PATH:ptr05215]
Human Diseases; Cancers; Endometrial cancer [PATH:ptr05213]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:ptr05223]
Human Diseases; Neurodegenerative diseases; Prion diseases [PATH:ptr05020]
Human Diseases; Substance dependence; Alcoholism [PATH:ptr05034]
Human Diseases; Infectious diseases; Influenza A [PATH:ptr05164]
Human Diseases; Infectious diseases; Hepatitis B [PATH:ptr05161]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
15
AA seq 393 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVQPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERFQGTHY
SVQSDIWSMGLSPVEMAVGRYPIPSPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtccagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagattccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctccggtagagatggcagttgggagg
tatcccatcccttctccggatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacccaggccaaggaccccagggaggcctcttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcctaattaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcgggttggctctgctccaccatcggg
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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