KEGG   Pan troglodytes (chimpanzee): 453330Help
Entry
453330            CDS       T01005                                 

Gene name
PLCB2
Definition
phospholipase C, beta 2
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ptr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    453330 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    453330 (PLCB2)
   04310 Wnt signaling pathway
    453330 (PLCB2)
   04020 Calcium signaling pathway
    453330 (PLCB2)
   04070 Phosphatidylinositol signaling system
    453330 (PLCB2)
   04022 cGMP - PKG signaling pathway
    453330 (PLCB2)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    453330 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    453330 (PLCB2)
   04062 Chemokine signaling pathway
    453330 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    453330 (PLCB2)
   04912 GnRH signaling pathway
    453330 (PLCB2)
   04915 Estrogen signaling pathway
    453330 (PLCB2)
   04921 Oxytocin signaling pathway
    453330 (PLCB2)
   04918 Thyroid hormone synthesis
    453330 (PLCB2)
   04919 Thyroid hormone signaling pathway
    453330 (PLCB2)
   04916 Melanogenesis
    453330 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    453330 (PLCB2)
   04270 Vascular smooth muscle contraction
    453330 (PLCB2)
  Digestive system
   04970 Salivary secretion
    453330 (PLCB2)
   04971 Gastric acid secretion
    453330 (PLCB2)
   04972 Pancreatic secretion
    453330 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    453330 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    453330 (PLCB2)
   04725 Cholinergic synapse
    453330 (PLCB2)
   04728 Dopaminergic synapse
    453330 (PLCB2)
   04726 Serotonergic synapse
    453330 (PLCB2)
   04720 Long-term potentiation
    453330 (PLCB2)
   04730 Long-term depression
    453330 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    453330 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    453330 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    453330 (PLCB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    453330 (PLCB2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    453330 (PLCB2)
   05016 Huntington's disease
    453330 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    453330 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    453330 (PLCB2)
   05143 African trypanosomiasis
    453330 (PLCB2)
Enzymes [BR:ptr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     453330 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
15
AA seq 1187 aa AA seqDB search
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKVWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEINEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGE
AEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSTNSINPVWKEEPFVFEKIGILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYH
HLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMG
GLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGV
VKLQRRHEKELRELERRGARRWEELLQRGAEQLAELGPPGVGGVGACKLGPGKGSRKKRS
LPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHAAEQISKMM
ELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNS
HIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEV
KESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
NT seq 3564 nt NT seq  +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaactacagttgcctctccagttatcctccgtgtg
gatcctaagggctactacttatactggacgtatcaaagtaaggagatggagtttctggat
atcaccagcatccgggatactcgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggacgtcttcaacatggactttcctgacaacagtttcctgctgaagacactcacg
gtggtgtccggcccggacatggtggacctcaccttccacaacttcgtctcctacaaggag
aacgtgggcaaggtctgggctgaggacgtactggccctagtcaaacatccgctgacggcc
aacgcctcccgcagcaccttcctggacaagatccttgtgaagctcaagatgcagctcaac
tctgaagggaagattccggtgaagaactttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgctctcagtgcctgccacctccccaaaggcaaaaatgatgccatcaatcct
gaggacttcccagaacctgtctacaagagtttcctcatgagcctctgtcctcggccagaa
ataaatgagatcttcacttcttaccatgctaaggccaaaccctacatgacgaaggagcac
ctgaccaaattcatcaaccagaaacagcgggactcccggcttaactccctgctgttcccg
ccagcacggcctgaccaggtgcagggcctcatcgacaagtatgagcccagtggcatcaat
gcacagaggggccagctgtcacctgaaggcatggtctggtttctctgtgggccagagaac
agcgtgctggcccaggacaagctgctgctccaccacgacatgacgcagccactcaatcat
tacttcatcaactcgtcccacaacacctacctgacagccggccagttctcaggcctctcc
tcggctgagatgtaccgccaggtgctgctctctggctgccgttgcgtggagctagactgc
tggaaggggaaaccccctgacgaggagcccattatcacccatggcttcaccatgaccaca
gacatcttcttcaaagaagcaattgaggctattgcagaaagtgcctttaagacctccccc
tatcccatcatcctgtcttttgagaaccatgtggactcaccccgccagcaggctaagatg
gctgagtactgccggacgatctttggggatatgctgctcacagagcccctggaaaagttc
ccactaaaaccaggtgtccccctgcccagccctgaggacctcaggggcaagatcctcatc
aagaacaagaagaaccagttttctggccccacctcctccagtaaggatactggtggggag
gctgagggcagcagcccacccagtgcccctgcaggtgagggcacagtgtgggctggcgag
gaagggactgagctggaggaggaggaggtggaagaggaagaggaggaggagtcaggaaac
ctggatgaagaagagattaagaagatgcagtcggatgagggcacagcgggcctggaagtg
acggcttatgaggagatgtccagcctagtcaattacatccagcccaccaagttcgtctcc
tttgagttctctgcccaaaagaaccgaagttatgtcatctcgtccttcacagagctcaag
gcatatgacctgctctccaaggcctcggtgcagtttgtggactacaacaagcgccagatg
agccgcatttaccccaagggaacccgcatggactcctccaactacatgccccagatgttc
tggaatgctggatgccagatggttgccctcaacttccagacgatggacttgcccatgcag
cagaacatggcagtgtttgagttcaacgggcagagcggctacctcctcaagcatgagttc
atgcgccggccggacaagcagttcaaccccttctcagtggaccgcatcgacgtggtggtg
gccaccaccctttccattacggtgatctctgggcagttcctgtcagaacgcagcgtgcgc
acctatgtggaagtggagctgtttggccttcctggggaccccaagaggcgctatcgaact
aagctgtcacccagtactaactccatcaatcctgtctggaaggaggagccctttgtcttt
gagaagattgggatcttgatgcctgagctggcctccctcagagtggctgtgatggaggaa
ggcaacaagtttcttggacaccgcatcatccccatcaatgccctaaattctgggtaccac
cacctgtgcctgcacagtgagagcaacatgcccctcaccatgcctgcgctcttcatattc
ctggagatgaaggactacatacctggtgcttgggcagatctcactgtggccctcgccaac
cccattaagttcttcagtgcccatgacacgaagtctgtgaagctcaaggaggccatggga
ggtctgcctgagaagcccttcccactggcgagtccagttgccagccaggtcaatggggcg
ttggccccaacgagcaatgggtcaccagcagccagggccggggccagggaagaggctatg
aaagaagctgcggagccgcggaccgccagcctggaggagctccgggagctaaagggcgtg
gtgaagctgcagcggcggcacgagaaggagctgcgagagttggagcggcgcggagcgcgg
cgctgggaggagctgctgcagcggggcgcggagcagctggcggagctcgggccaccgggc
gtggggggtgtcggggcctgcaagctcggtcccggcaagggctctcgcaagaagaggagc
ctgccccgcgaggagagcgccggagccgcgccgggcgagggccctgagggcgtggacggg
cgcgtgcgggagctgaaagacaggctggagctggagctgctgcggcagggcgaggagcag
tacgagtgcgttctgaagcgcaaggagcagcacgcggccgagcaaatctccaaaatgatg
gagctggccagagagaaacaggcggcagagctgaaggccctgaaggagacgtcggagaac
gacaccaaagagatgaagaaaaagctggagacaaagagactggagcggatccagggcatg
accaaagtcaccacagacaagatggcccaggagaggttgaagagagagattaacaactcc
cacatccaggaagtagtgcaggtgatcaagcagatgacggagaacttggagaggcaccag
gagaagctggaggagaagcaggcggcttgcctggaacagatacgggagatggaaaagcag
ttccagaaggaggcgctggcagagtacgaggccaggatgaagggtctggaggcagaggtg
aaggagtcggtgagggcctgcctcaggacctgctttccctctgaggccaaggacaagcct
gagagggcctgcgagtgccccccagagctgtgtgagcaggacccactcatagcaaaggca
gatgcccaggagagccgcctctga

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