KEGG   Pan troglodytes (chimpanzee): 456390Help
Entry
456390            CDS       T01005                                 

Gene name
MAP2K2
Definition
mitogen-activated protein kinase kinase 2
Orthology
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Gap junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ptr00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    456390 (MAP2K2)
   04015 Rap1 signaling pathway
    456390 (MAP2K2)
   04010 MAPK signaling pathway
    456390 (MAP2K2)
   04012 ErbB signaling pathway
    456390 (MAP2K2)
   04370 VEGF signaling pathway
    456390 (MAP2K2)
   04066 HIF-1 signaling pathway
    456390 (MAP2K2)
   04068 FoxO signaling pathway
    456390 (MAP2K2)
   04022 cGMP - PKG signaling pathway
    456390 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    456390 (MAP2K2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    456390 (MAP2K2)
  Cell communication
   04540 Gap junction
    456390 (MAP2K2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    456390 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    456390 (MAP2K2)
   04660 T cell receptor signaling pathway
    456390 (MAP2K2)
   04662 B cell receptor signaling pathway
    456390 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    456390 (MAP2K2)
  Endocrine system
   04910 Insulin signaling pathway
    456390 (MAP2K2)
   04912 GnRH signaling pathway
    456390 (MAP2K2)
   04915 Estrogen signaling pathway
    456390 (MAP2K2)
   04917 Prolactin signaling pathway
    456390 (MAP2K2)
   04921 Oxytocin signaling pathway
    456390 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    456390 (MAP2K2)
   04916 Melanogenesis
    456390 (MAP2K2)
  Circulatory system
   04270 Vascular smooth muscle contraction
    456390 (MAP2K2)
  Nervous system
   04720 Long-term potentiation
    456390 (MAP2K2)
   04730 Long-term depression
    456390 (MAP2K2)
   04722 Neurotrophin signaling pathway
    456390 (MAP2K2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    456390 (MAP2K2)
   05206 MicroRNAs in cancer
    456390 (MAP2K2)
   05205 Proteoglycans in cancer
    456390 (MAP2K2)
   05214 Glioma
    456390 (MAP2K2)
   05216 Thyroid cancer
    456390 (MAP2K2)
   05221 Acute myeloid leukemia
    456390 (MAP2K2)
   05220 Chronic myeloid leukemia
    456390 (MAP2K2)
   05218 Melanoma
    456390 (MAP2K2)
   05211 Renal cell carcinoma
    456390 (MAP2K2)
   05219 Bladder cancer
    456390 (MAP2K2)
   05215 Prostate cancer
    456390 (MAP2K2)
   05213 Endometrial cancer
    456390 (MAP2K2)
   05223 Non-small cell lung cancer
    456390 (MAP2K2)
  Neurodegenerative diseases
   05020 Prion diseases
    456390 (MAP2K2)
  Infectious diseases
   05164 Influenza A
    456390 (MAP2K2)
   05161 Hepatitis B
    456390 (MAP2K2)
Enzymes [BR:ptr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     456390 (MAP2K2)
Protein kinases [BR:ptr01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   456390 (MAP2K2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
19
AA seq 303 aa AA seqDB search
MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ
VLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSG
QLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEA
IFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGV
FTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTR
TAV
NT seq 912 nt NT seq  +upstreamnt  +downstreamnt
atggccaggaagctgatccaccttgagatcaagccggccatccggaaccagatcatccgc
gagctgcaggtcctgcacgaatgcaactcgccgtacatcgtgggcttctacggggccttc
tacagtgacggggagatcagcatctgtatggaacacatggatggcggctccctggaccag
gtgctgaaagaggccaagaggattcccgaggagatcctggggaaagtcagcatcgcggtt
ctccggggcttggcgtacctccgagagaagcaccagatcatgcaccgagatgtgaagccc
tccaacatcctcgtgaactctagaggggagatcaagctgtgtgacttcggggtgagcggc
cagctcatcgactccatggccaactccttcgtgggcacgcgctcctacatggctccggag
cggttgcagggcacacattactcggtgcagtcggacatctggagcatgggcctgtccctg
gtggagctggccgtcggaaggtaccccatccccccgcccgacgccaaagagctggaggcc
atctttggccggcccgtggtcgacggggaagaaggagagcctcacagcatctcgcctcgg
ccgaggccccccgggcgccccgtcagcggtcacgggatggatagccggcccgccatggcc
atctttgaactcctggactatattgtgaacgagccgcctcctaagctgcccaacggtgtg
ttcacccccgacttccaggagtttgtcaataaatgcctcatcaagaacccagcggagcgg
gcggacctgaagatgctcacaaaccacaccttcatcaagcggtccgaggtggaagaagtg
gattttgctggctggttgtgtaaaaccctgcggctgaaccagcccggcacacccacgcgc
accgccgtgtga

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