KEGG   Pan troglodytes (chimpanzee): 457945Help
Entry
457945            CDS       T01005                                 

Gene name
MTOR, FRAP1
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ptr00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    457945 (MTOR)
   04066 HIF-1 signaling pathway
    457945 (MTOR)
   04151 PI3K-Akt signaling pathway
    457945 (MTOR)
   04152 AMPK signaling pathway
    457945 (MTOR)
   04150 mTOR signaling pathway
    457945 (MTOR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    457945 (MTOR)
   04920 Adipocytokine signaling pathway
    457945 (MTOR)
   04919 Thyroid hormone signaling pathway
    457945 (MTOR)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    457945 (MTOR)
   05206 MicroRNAs in cancer
    457945 (MTOR)
   05205 Proteoglycans in cancer
    457945 (MTOR)
   05214 Glioma
    457945 (MTOR)
   05221 Acute myeloid leukemia
    457945 (MTOR)
   05215 Prostate cancer
    457945 (MTOR)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    457945 (MTOR)
Protein kinases [BR:ptr01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [OT]
   457945 (MTOR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
1
AA seq 2567 aa AA seqDB search
MDRERGRARSWGRARTAGKAGGGAGGLKRRCRCWRRQLRPRPKPREPQGKMLGTGPAAAT
TAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHH
IFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAI
GRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPF
FDNIFVAVWDPKQAIREGAVAALRACLILXTQREPKEMQKLSGGALLPNLEQNQVPCKRL
REEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGL
MGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAF
RPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAA
LPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLY
DLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSI
TLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAH
VVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALND
QVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVS
NAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFI
IIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRR
EAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLP
LDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIR
VCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVA
LGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLF
DAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVF
QLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQG
DALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRS
CWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAE
FMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNK
LQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMR
CLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHD
GAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEV
IQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGK
SGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQ
TMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEH
DRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTA
STEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQD
TLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLT
DIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAIL
WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQ
EWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPG
TYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLF
GLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN
IEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTR
SLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRM
LTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRS
RTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIIN
RVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 7704 nt NT seq  +upstreamnt  +downstreamnt
atggaccgggagcggggacgggccaggagctggggccgggcgaggacagcggggaaggcg
ggcggtggggcagggggcctgaagcggaggtgccggtgctggcggcggcagctgaggcct
cggccgaagccgcgcgaacctcagggcaagatgcttggaaccggacctgccgccgccacc
accgctgccaccacatctagcaatgtgagcgtcctgcagcagtttgccagtggcctaaag
agccggaatgaggaaaccagggccaaagccgccaaggagctccagcactatgtcactatg
gaactccgagagatgagtcaagaggagtctactcgcttctatgaccaactgaaccatcac
atttttgaattggtttccagctcagatgccaatgagaggaaaggtggcatcttggccata
gctagcctcataggagtggaaggtgggaatgccacccgaattggcagatttgccaactat
cttcggaacctcctcccctccaatgacccagttgtcatggaaatggcatccaaggccatt
ggccgtcttgccatggcaggggacacttttaccgctgagtacgtggaatttgaggtgaag
cgagccctggaatggctgggtgctgaccgcaatgagggccggagacatgcagctgtcctg
gttctccgtgagctggccatcagcgtccctaccttcttcttccagcaagtgcaacccttc
tttgacaacatttttgtggccgtgtgggaccccaaacaggccatccgtgagggagctgta
gccgcccttcgtgcctgtctgattctcnacacccagcgtgagccgaaagagatgcagaag
ctcagtggtggtgctcttctgcctaacttagaacaaaatcaggtcccttgcaagcgtctg
agagaagaaatggaagaaatcacacagcagcagctggtacacgacaagtactgcaaagat
ctcatgggcttcggaacaaaacctcgtcacattacccccttcaccagtttccaggctgta
cagccccagcagtcaaatgccttggtggggctgctggggtacagctctcaccaaggcctc
atgggatttgggacctcccccagtccagctaagtccaccctggtggagagccggtgttgc
agagacttgatggaggagaaatttgatcaggtgtgccagtgggtgctgaaatgcaggaat
agcaagaactcgctgatccaaatgacaatccttaatttgttgccccgcttggctgcattc
cgaccttctgccttcacagatacccagtatctccaagataccatgaaccatgtcctaagc
tgtgtcaagaaggagaaggaacgtacagcggccttccaagccctggggctactttccgtg
gctgtgaggtctgagtttaaggtctatttgcctcgcgtgctggacatcatccgagcggcc
ctgcccccaaaggacttcgcccataagaggcagaaggcaatgcaggtggacgccacagtc
ttcacttgcatcagcatgctggctcgagcaatggggccaggcatccagcaggatatcaag
gagctgctggagcccatgctggcagtgggactaagccctgccctcactgcagtgctctac
gacctgagccgtcagattccacagctaaagaaggacattcaagatgggctactgaaaatg
ctgtccctggtccttatgcacaaacccctccgccacccaggcatgcccaagggcctggcc
catcagctggcctctcctggcctcacgaccctccctgaggccagcgatgtgggcagcatc
actcttgccctccgaacgcttggcagctttgaatttgaaggccactctctgacccaattt
gttcgccactgtgcggatcatttcctgaacagtgagcacaaggagatccgcatggaggct
gcccgcacctgctcccgcctgctcacaccctccatccacctcatcagtggccatgctcat
gtggttagccagactgcagtgcaagtggtggcagatgtgcttagcaaactgctcgtagtt
gggataacagatcctgaccctgacattcgctattgtgtcttggcgtccctggacgagcgc
tttgatgcacacctggcccaggcggagaacttgcaggccttgtttgtggctctgaatgac
caggtgtttgagatccgggagctggccatctgcactgtgggccgactcagtagcatgaac
cctgcctttgtcatgcctttcctgcgcaagatgctcatccagattttgacagagttggag
cacagtgggattggaagaatcaaagagcagagtgcccgcatgctggggcacctggtctcc
aatgccccccgactcatccgcccctacatggagcctattctgaaggcattaattttgaaa
ctgaaagatccagaccctgatccaaacccaggtgtgatcaataatgtcctagcaacaata
ggagaattggcacaggttagtggcctggaaatgaggaaatgggttgatgaactttttatt
atcatcatggacatgctccaggattcctctttgttggccaaaaggcaggtggctctgtgg
accctgggacagttggtggccagcactggctatgtagtagagccctacaggaagtaccct
actttgcttgaggtgctactgaattttctgaagactgagcagaaccagggtacacgcaga
gaggccatccgtgtgttagggcttttaggggctttggatccttacaagcacaaagtgaac
attggcatgatagaccagtcccgggatgcctctgctgtcagcctgtcagaatccaagtca
agtcaggattcctctgactatagcactagtgaaatgctggtcaacatgggaaacttgcct
ctggatgagttctacccagctgtgtccatggtggccctgatgcggatcttccgagaccag
tcactctctcatcatcacaccatggttgtccaggccatcaccttcatcttcaagtccctg
ggactcaaatgtgtgcagttcctgccccaggtcatgcccacgttccttaatgtcattcga
gtctgtgatggggccatccgggaatttttgttccagcagctgggaatgttggtgtccttt
gtgaagagccacatcagaccttatatggatgaaatagtcaccctcatgagagaattctgg
gtcatgaacacctcaattcagagcacgatcattcttctcattgagcaaattgtggtagct
cttgggggtgaatttaagctctacctgccccagctgatcccacacatgctgcgtgtcttc
atgcatgacaacagcccaggccgcattgtctctatcaagttactggctgcaatccagctg
tttggcgccaacctggatgactacctgcatttactgctgcctcctattgttaagttgttt
gatgcccctgaagctccactgccatctcgaaaggcagcgctagagactgtggaccgcctg
acggagtccctggatttcactgactatgcctcccggatcattcaccctattgttcgaaca
ctggaccagagcccagaactgcgctccacagccatggacacgctgtcttcacttgttttt
cagctggggaagaagtaccaaattttcattccaatggtgaataaagttctggtgcgacac
cgaatcaatcatcagcgctatgatgtgctcatctgcagaattgtcaagggatacacactt
gctgatgaagaggaggatcctttgatttaccagcatcggatgcttaggagtggccaaggg
gatgcattggctagtggaccagtggaaacaggacccatgaagaaactgcacgtcagcacc
atcaacctccaaaaggcctggggcgctgccaggagggtctccaaagatgactggctggaa
tggctgagacggctgagcctggagctgctgaaggactcatcatcgccctccctgcgctcc
tgctgggccctggcacaggcctacaacccgatggccagggatctcttcaatgctgcattt
gtgtcctgctggtctgaactgaatgaagatcaacaggatgagctcatcagaagcatcgag
ttggccctcacctcacaagacatcgctgaagtcacacagaccctcttaaacttggctgaa
ttcatggaacacagtgacaagggccccctgccactgagagatgacaatggcattgttctg
ctgggtgagagagctgccaagtgccgagcatatgccaaagcactacactacaaagaactg
gagttccagaaaggccccacccctgccattctagaatctctcatcagcattaataataag
ctacagcagccggaggcagcggccggagtgttagaatatgccatgaaacactttggagag
ctggagatccaggctacctggtatgagaaactgcacgagtgggaggatgcccttgtggcc
tatgacaagaaaatggacaccaacaaggacgacccagagctgatgctgggccgcatgcgc
tgcctcgaggccttgggggaatggggtcaactccaccagcagtgctgcgaaaagtggacc
ctggttaatgatgagacccaagccaagatggcccggatggctgctgcagctgcatggggt
ttaggtcagtgggacagcatggaagaatacacctgtatgatccctcgggacacccatgat
ggggcattttatagagctgtgctggcactgcatcaggacctcttctccttggcacaacag
tgcattgacaaggccagggacctgctggatgctgaattaactgcgatggcaggagagagt
tacagtcgggcatatggggccatggtttcttgccacatgctgtccgagctggaggaggtt
atccagtacaaacttgtccccgagcgacgagagatcatccgccagatctggtgggagaga
ctgcagggctgccagcgtatcgtagaggactggcagaaaatccttatggtgcggtccctt
gtggtcagtcctcatgaagacatgagaacctggctcaagtatgcaagcctgtgcggcaag
agtggcaggctggctcttgctcataaaactttagtgttgctcctgggagttgatccgtct
cggcaacttgaccatcctctgccaacagttcaccctcaggtgacctatgcctacatgaaa
aacatgtggaagagtgcccgcaagatcgatgccttccagcacatgcagcattttgtccag
accatgcagcaacaggcccagcatgccatcgctactgaggaccagcagcataagcaggaa
ctgcacaagctcatggcccgatgcttcctgaaacttggagagtggcagctgaatctacag
ggcatcaatgagagcacaatccccaaagtgctgcagtactacagcgccgccacagagcac
gaccgcagctggtacaaggcctggcatgcgtgggcagtgatgaacttcgaagctgtgcta
cactacaaacatcagaaccaagcccgcgatgagaagaagaaactgcgtcatgccagcggg
gccaacatcaccaacgccaccactgccgccaccacggccgccactgccaccaccactgcc
agcaccgagggcagcaacagtgagagcgaggccgagagcaccgagaacagccccacccca
tcgccgctgcagaagaaggtcactgaggatctgtccaaaaccctcctgatgtacacggtg
cctgccgtccagggcttcttccgttccatctccttgtcacgaggcaacaacctccaggat
acactcagagttctcaccttatggtttgattatggtcactggccagatgtcaatgaggcc
ttagtggagggggtgaaagccatccagattgatacctggctacaggttatacctcagctc
attgcaagaattgatacgcccagacccttggtgggacgtctcattcaccagcttctcaca
gacattggtcggtaccacccccaggccctcatctacccgctgacagtggcttctaagtct
accacgacagcccggcacaatgcagccaacaagattctgaagaacatgtgtgagcacagc
aacaccctggtccagcaggccatgatggtgagcgaggagctgatccgagtggccatcctc
tggcatgagatgtggcatgaaggcctggaagaggcatctcgtttgtactttggggaaagg
aacgtgaaaggcatgtttgaggtgctggagcccttgcatgctatgatggaacggggcccc
cagactctgaaggaaacatcctttaatcaggcctatggtcgagatttaatggaggcccaa
gagtggtgcaggaagtacatgaaatcagggaatgtcaaggacctcacccaagcctgggac
ctctattatcatgtgttccgacgaatctcaaagcagctgcctcagctcacatccttagag
ctgcaatatgtttccccaaaacttctgatgtgccgggaccttgaattggctgtgccagga
acatatgaccccaaccagccaatcattcgcattcagtccatagcaccgtctttgcaagtc
atcacatccaagcagaggccccggaaattgacacttatgggcagcaacgggcatgagttt
gttttccttctaaaaggccatgaagatctgcgccaggatgagcgtgtgatgcagctcttc
ggcctggttaacacccttctggccaatgacccaacatctcttcggaaaaacctcagcatc
cagagatatgctgtcatccctttatcgaccaactcgggcctcattggctgggttccccac
tgtgacacactgcacgctctcatccgggactacagggagaagaagaagatccttctcaac
atcgagcatcgcatcatgttgcggatggctccggactatgaccacttgactctgatgcag
aaggtggaggtgtttgagcatgccgtcaataatacagctggggacgacctggccaagctg
ctgtggctgaaaagccccagctctgaggtgtggtttgaccgaagaaccaattatacccgt
tctttagcggtcatgtcaatggttgggtatattttaggcctgggagatagacacccatcc
aacctgatgctggaccgtctgagtgggaagatcctgcacattgactttggggactgcttt
gaggttgctatgacccgagagaagtttccagagaagattccatttagactaacaagaatg
ttgaccaatgctatggaggttacaggcctggatggcaactacagaatcacatgccacaca
gtgatggaggtgctgcgagagcacaaggacagtgtcatggccgtgctggaagcctttgtc
tatgaccccttgctgaactggaggctgatggacacaaatacgaaaggcaacaagcgatcc
cgaacgaggacggattcctactctgctggccagtcagtcgaaattttggacggtgtggaa
cttggagagccagcccataagaaaacggggaccacagtgccagaatctattcattctttc
attggagacggtttggtgaaaccagaggccctaaataagaaagctatccagattattaac
agggttcgagataagctcactggtcgggacttctctcatgatgacactttggatgttcca
acgcaagttgagctgctcatcaaacaagcgacatcccatgaaaacctctgccagtgctat
attggctggtgccctttctggtaa

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