KEGG   Pan troglodytes (chimpanzee): 458093Help
Entry
458093            CDS       T01005                                 

Gene name
PLCB4
Definition
(RefSeq) phospholipase C beta 4
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ptr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    458093 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    458093 (PLCB4)
   04310 Wnt signaling pathway
    458093 (PLCB4)
   04020 Calcium signaling pathway
    458093 (PLCB4)
   04070 Phosphatidylinositol signaling system
    458093 (PLCB4)
   04072 Phospholipase D signaling pathway
    458093 (PLCB4)
   04071 Sphingolipid signaling pathway
    458093 (PLCB4)
   04022 cGMP - PKG signaling pathway
    458093 (PLCB4)
 Cellular Processes
  Cellular community
   04540 Gap junction
    458093 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    458093 (PLCB4)
   04062 Chemokine signaling pathway
    458093 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    458093 (PLCB4)
   04922 Glucagon signaling pathway
    458093 (PLCB4)
   04912 GnRH signaling pathway
    458093 (PLCB4)
   04915 Estrogen signaling pathway
    458093 (PLCB4)
   04921 Oxytocin signaling pathway
    458093 (PLCB4)
   04918 Thyroid hormone synthesis
    458093 (PLCB4)
   04919 Thyroid hormone signaling pathway
    458093 (PLCB4)
   04916 Melanogenesis
    458093 (PLCB4)
   04924 Renin secretion
    458093 (PLCB4)
   04925 Aldosterone synthesis and secretion
    458093 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    458093 (PLCB4)
   04270 Vascular smooth muscle contraction
    458093 (PLCB4)
  Digestive system
   04970 Salivary secretion
    458093 (PLCB4)
   04971 Gastric acid secretion
    458093 (PLCB4)
   04972 Pancreatic secretion
    458093 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    458093 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    458093 (PLCB4)
   04725 Cholinergic synapse
    458093 (PLCB4)
   04728 Dopaminergic synapse
    458093 (PLCB4)
   04726 Serotonergic synapse
    458093 (PLCB4)
   04720 Long-term potentiation
    458093 (PLCB4)
   04730 Long-term depression
    458093 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    458093 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    458093 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    458093 (PLCB4)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    458093 (PLCB4)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    458093 (PLCB4)
   05016 Huntington's disease
    458093 (PLCB4)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    458093 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    458093 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    458093 (PLCB4)
   05143 African trypanosomiasis
    458093 (PLCB4)
Enzymes [BR:ptr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     458093 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
20
AA seq 1203 aa AA seqDB search
MAGEKGREKKEVLNIIMAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPSCLFKVDEF
GFFLTWKSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGT
DLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKI
PVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPVAFSYEKFYELTQKICPRTDIED
LFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKK
GLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVE
MYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPV
ILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKR
LKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADD
LGHKEAVANSVKKASDDLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYA
QPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSS
NYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSE
TPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY
NEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLP
TIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKN
DKKGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHL
KKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCL
EMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKK
LLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNS
SNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPA
TVV
NT seq 3612 nt NT seq  +upstreamnt  +downstreamnt
atggcaggggagaaaggaagggaaaaaaaggaggtcttgaatataatcatggccaaacct
tatgaatttaactggcagaaggaagttccttcctttttgcaagaaggagcagtttttgac
agatacgaagaggaatcctttgtgtttgaacccagctgcctcttcaaagtggatgagttt
ggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgctagaatgctccctc
atcaacagtattcggtcgggagccataccaaaggatcccaaaattttggctgctcttgaa
gctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtctgcagtggcaca
gatctagtgaacattagttttacctacatggtggctgaaaatccagaagtaactaagcaa
tgggtagaaggcctgagatcaatcatacacaacttcagggccaacaacgtcagtccaatg
acatgcctcaagaaacactggatgaaattggcatttatgaccaacacaaatggtaaaatt
ccagttaggagtattactagaacatttgcatcgggaaaaacagaaaaggtgatctttcaa
gcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgagcccgtggcattt
tcttatgaaaagttctatgaactgacacaaaagatttgtcctcggacagatatagaagat
cttttcaaaaaaatcaatggagacaaaactgattatttaacggtagaccaattagtgagc
tttctaaatgaacatcaacgagatcctcgattgaatgaaattttatttccattttatgat
gccaaaagggcaatgcagatcattgagatgtatgaacctgacgaagatttgaagaaaaaa
ggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaaaacgccccagtc
ttcctagatcgtttagaactttaccaagaaatggaccatcctctggctcactacttcatc
agttcttcccataacacttatctcactggcagacagttcggcgggaagtcttcggtagaa
atgtacagacaggttctcctggctggttgcagatgtgttgaacttgactgctgggatgga
aaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgtacagatatcctt
tttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatcagaatatcctgta
attctctcctttgaaaatcactgcagcaaatatcaacagtacaagatgtccaaatattgc
gaagatctatttggggatctcctgttgaaacaagcacttgaatcacatccacttgaacca
ggcagggctttgccatcccccaatgacctcaaaagaaaaatactcataaaaaacaagcgg
ctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatgatggaagctgga
gaatctgcctccccagcaaacatcttagaggacgataatgaagaggagatcgaaagtgct
gaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactttctgctgatgac
ttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcttcagatgaccttgaacat
gaaaacaacaaaaagggcctggtcactgtagaagatgagcaggcgtggatggcatcttat
aaatatgtaggtgctaccactaatatccatccatatttgtccacaatgatcaactacgcc
cagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatattcattataacatg
tcgtcttttaatgaatcagtcggtcttggctacttgaagacacatgcaattgaatttgtc
aattataacaaacggcaaatgagtcgcatttaccccaagggaggccgagtcgattccagt
aattacatgcctcagattttctggaacgctggctgccagatggtttcgctgaactatcaa
accccagatttagcgatgcaattgaatcagggaaaatttgagtataatggatcgtgcggg
taccttctcaaaccagatttcatgaggcggcctgatcgaacatttgaccccttctctgaa
actcctgttgatggtgttattgcagccacttgctcagtgcaggttatatcaggtcaattc
ttatcagataagaaaattggcacctacgtagaggtggatatgtatgggttgcccactgac
accatacgtaaggaattccgaactcgcatggttatgaataatggactcaatccagtttac
aatgaagagtcatttgtatttcggaaggtgatcctgccagacctggctgtcttgagaata
gctgtgtatgatgataacaacaagctgattggccagaggatcctcccgcttgatggcctc
caagccggatatcgacacatttcccttcgaaatgagggaaataaaccattatcactacca
acaattttctgcaatattgttcttaaaacatatgtgcctgatggatttggagatatcgtg
gatgctttatcagatccaaagaaatttctctcaattacagaaaagagagcagaccaaatg
agagctatgggcattgaaactagtgacatagccgacgtgcccagtgacacttccaaaaat
gacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcagagtagctctgag
ctcagaccaaccaccacggctgccctggcctctggtgtggaagccaagaaaggtattgaa
cttatccctcaagtaaggatagaagacttgaagcagatgaaggcttacttgaagcattta
aagaaacagcagaaggagctaaattctttaaagaagaaacatgcaaaggaacacagtacc
atgcagaagttacactgcacgcaagttgacaaaattgtggcacagtatgacaaagagaag
tcgactcatgagaaaatcctagagaaggcaatgaagaagaaggggggaagtaattgtctc
gaaatgaaaaaagaaacagaaatcaaaattcagacgctgacatcagatcacaaatctaag
gtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatcaatacccacagt
gctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgagctgctgaaaaag
ctactcatcaatgcccacgagcagcaaacccagcagctgaaactgtcccatgacagggaa
agcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagcaaagccatcagc
caagataaatctatcaagaataaagcagaacgggaaaggcgagtcagggagttaaacagc
agcaacactaaaaagtttctggaagaaagaaagagacttgccatgaagcagtccaaagaa
atggatcagttgaaaaaagtccagcttgaacatctagaattcctagagaaacagaatgag
caggcgaaggagatgcagcagatggtgaaattggaagccgagatggaccgcagaccagca
acagtagtatga

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