KEGG   Pan troglodytes (chimpanzee): 458680Help
Entry
458680            CDS       T01005                                 

Gene name
MAPK1
Definition
mitogen-activated protein kinase 1
Orthology
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ptr00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    458680 (MAPK1)
   04015 Rap1 signaling pathway
    458680 (MAPK1)
   04010 MAPK signaling pathway
    458680 (MAPK1)
   04012 ErbB signaling pathway
    458680 (MAPK1)
   04350 TGF-beta signaling pathway
    458680 (MAPK1)
   04370 VEGF signaling pathway
    458680 (MAPK1)
   04668 TNF signaling pathway
    458680 (MAPK1)
   04066 HIF-1 signaling pathway
    458680 (MAPK1)
   04068 FoxO signaling pathway
    458680 (MAPK1)
   04022 cGMP - PKG signaling pathway
    458680 (MAPK1)
   04151 PI3K-Akt signaling pathway
    458680 (MAPK1)
   04150 mTOR signaling pathway
    458680 (MAPK1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    458680 (MAPK1)
  Cell growth and death
   04114 Oocyte meiosis
    458680 (MAPK1)
  Cell communication
   04510 Focal adhesion
    458680 (MAPK1)
   04520 Adherens junction
    458680 (MAPK1)
   04540 Gap junction
    458680 (MAPK1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    458680 (MAPK1)
   04620 Toll-like receptor signaling pathway
    458680 (MAPK1)
   04621 NOD-like receptor signaling pathway
    458680 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    458680 (MAPK1)
   04660 T cell receptor signaling pathway
    458680 (MAPK1)
   04662 B cell receptor signaling pathway
    458680 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    458680 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    458680 (MAPK1)
   04062 Chemokine signaling pathway
    458680 (MAPK1)
  Endocrine system
   04910 Insulin signaling pathway
    458680 (MAPK1)
   04912 GnRH signaling pathway
    458680 (MAPK1)
   04915 Estrogen signaling pathway
    458680 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    458680 (MAPK1)
   04917 Prolactin signaling pathway
    458680 (MAPK1)
   04921 Oxytocin signaling pathway
    458680 (MAPK1)
   04919 Thyroid hormone signaling pathway
    458680 (MAPK1)
   04916 Melanogenesis
    458680 (MAPK1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    458680 (MAPK1)
   04270 Vascular smooth muscle contraction
    458680 (MAPK1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    458680 (MAPK1)
  Nervous system
   04724 Glutamatergic synapse
    458680 (MAPK1)
   04725 Cholinergic synapse
    458680 (MAPK1)
   04726 Serotonergic synapse
    458680 (MAPK1)
   04720 Long-term potentiation
    458680 (MAPK1)
   04730 Long-term depression
    458680 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    458680 (MAPK1)
   04722 Neurotrophin signaling pathway
    458680 (MAPK1)
  Development
   04320 Dorso-ventral axis formation
    458680 (MAPK1)
   04360 Axon guidance
    458680 (MAPK1)
   04380 Osteoclast differentiation
    458680 (MAPK1)
  Environmental adaptation
   04713 Circadian entrainment
    458680 (MAPK1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    458680 (MAPK1)
   05205 Proteoglycans in cancer
    458680 (MAPK1)
   05203 Viral carcinogenesis
    458680 (MAPK1)
   05210 Colorectal cancer
    458680 (MAPK1)
   05212 Pancreatic cancer
    458680 (MAPK1)
   05214 Glioma
    458680 (MAPK1)
   05216 Thyroid cancer
    458680 (MAPK1)
   05221 Acute myeloid leukemia
    458680 (MAPK1)
   05220 Chronic myeloid leukemia
    458680 (MAPK1)
   05218 Melanoma
    458680 (MAPK1)
   05211 Renal cell carcinoma
    458680 (MAPK1)
   05219 Bladder cancer
    458680 (MAPK1)
   05215 Prostate cancer
    458680 (MAPK1)
   05213 Endometrial cancer
    458680 (MAPK1)
   05223 Non-small cell lung cancer
    458680 (MAPK1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    458680 (MAPK1)
   05020 Prion diseases
    458680 (MAPK1)
  Substance dependence
   05034 Alcoholism
    458680 (MAPK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    458680 (MAPK1)
  Infectious diseases
   05132 Salmonella infection
    458680 (MAPK1)
   05133 Pertussis
    458680 (MAPK1)
   05152 Tuberculosis
    458680 (MAPK1)
   05164 Influenza A
    458680 (MAPK1)
   05161 Hepatitis B
    458680 (MAPK1)
   05160 Hepatitis C
    458680 (MAPK1)
   05145 Toxoplasmosis
    458680 (MAPK1)
   05140 Leishmaniasis
    458680 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    458680 (MAPK1)
Enzymes [BR:ptr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     458680 (MAPK1)
Protein kinases [BR:ptr01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [Table]
   458680 (MAPK1)
Exosome [BR:ptr04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   458680 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
22
AA seq 360 aa AA seqDB search
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1083 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaacctctcgtacatcggcgagggcgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagcccctttgag
caccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgacattattcgagcaccaaccatcgagcaaatgaaagat
gtatatatagtacaggacctcatggaaacagatctttacaagctcttgaagacacaacac
ctcagcaatgaccatatctgctattttctctaccagatcctcagagggttaaaatatatc
cattcagctaacgttctgcaccgtgacctcaagccttccaacctgctgctcaacaccacc
tgtgatctcaagatctgtgactttggcctggcccgtgttgcagatccagaccatgatcac
acagggttcctgacagaatatgtggccacacgttggtacagggctccagaaattatgttg
aattccaagggctacaccaagtccattgatatttggtctgtaggctgcattctggcagaa
atgctttctaacaggcccatctttccagggaagcattatcttgaccagctgaaccacatt
ttgggtattcttggatccccatcacaagaagacctgaattgtataataaatttaaaagct
aggaactatttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgactccaaagctctggacttattggacaaaatgttgacattcaacccacacaag
aggattgaagtagaacaggctctggcccacccatatctggagcagtattacgacccgagt
gacgagcccatcgccgaagcaccattcaagttcgacatggaattggatgacttgcctaag
gaaaagctcaaagaactaatttttgaagagactgctagattccagccaggatacagatct
taa

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