KEGG   Pan troglodytes (chimpanzee): 460858Help
Entry
460858            CDS       T01005                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ptr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    460858 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    460858 (PIK3CA)
   04015 Rap1 signaling pathway
    460858 (PIK3CA)
   04012 ErbB signaling pathway
    460858 (PIK3CA)
   04370 VEGF signaling pathway
    460858 (PIK3CA)
   04630 Jak-STAT signaling pathway
    460858 (PIK3CA)
   04668 TNF signaling pathway
    460858 (PIK3CA)
   04066 HIF-1 signaling pathway
    460858 (PIK3CA)
   04068 FoxO signaling pathway
    460858 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    460858 (PIK3CA)
   04024 cAMP signaling pathway
    460858 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    460858 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    460858 (PIK3CA)
   04152 AMPK signaling pathway
    460858 (PIK3CA)
   04150 mTOR signaling pathway
    460858 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    460858 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    460858 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    460858 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    460858 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    460858 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    460858 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    460858 (PIK3CA)
   04660 T cell receptor signaling pathway
    460858 (PIK3CA)
   04662 B cell receptor signaling pathway
    460858 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    460858 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    460858 (PIK3CA)
   04670 Leukocyte transendothelial migration
    460858 (PIK3CA)
   04062 Chemokine signaling pathway
    460858 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    460858 (PIK3CA)
   04915 Estrogen signaling pathway
    460858 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    460858 (PIK3CA)
   04917 Prolactin signaling pathway
    460858 (PIK3CA)
   04921 Oxytocin signaling pathway
    460858 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    460858 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    460858 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    460858 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    460858 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    460858 (PIK3CA)
   04722 Neurotrophin signaling pathway
    460858 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    460858 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    460858 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    460858 (PIK3CA)
   05230 Central carbon metabolism in cancer
    460858 (PIK3CA)
   05231 Choline metabolism in cancer
    460858 (PIK3CA)
   05205 Proteoglycans in cancer
    460858 (PIK3CA)
   05203 Viral carcinogenesis
    460858 (PIK3CA)
   05210 Colorectal cancer
    460858 (PIK3CA)
   05212 Pancreatic cancer
    460858 (PIK3CA)
   05214 Glioma
    460858 (PIK3CA)
   05221 Acute myeloid leukemia
    460858 (PIK3CA)
   05220 Chronic myeloid leukemia
    460858 (PIK3CA)
   05218 Melanoma
    460858 (PIK3CA)
   05211 Renal cell carcinoma
    460858 (PIK3CA)
   05215 Prostate cancer
    460858 (PIK3CA)
   05213 Endometrial cancer
    460858 (PIK3CA)
   05222 Small cell lung cancer
    460858 (PIK3CA)
   05223 Non-small cell lung cancer
    460858 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    460858 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    460858 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    460858 (PIK3CA)
   05166 HTLV-I infection
    460858 (PIK3CA)
   05162 Measles
    460858 (PIK3CA)
   05164 Influenza A
    460858 (PIK3CA)
   05161 Hepatitis B
    460858 (PIK3CA)
   05160 Hepatitis C
    460858 (PIK3CA)
   05169 Epstein-Barr virus infection
    460858 (PIK3CA)
   05146 Amoebiasis
    460858 (PIK3CA)
   05145 Toxoplasmosis
    460858 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    460858 (PIK3CA)
Enzymes [BR:ptr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     460858 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
3
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaagaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatactgtgtagctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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