KEGG   Pan troglodytes (chimpanzee): 469875Help
Entry
469875            CDS       T01005                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:ptr00562]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:ptr04015]
Environmental Information Processing; Signal transduction; Wnt signaling pathway [PATH:ptr04310]
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:ptr04020]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:ptr04070]
Cellular Processes; Cell communication; Gap junction [PATH:ptr04540]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:ptr04062]
Organismal Systems; Endocrine system; Insulin secretion [PATH:ptr04911]
Organismal Systems; Endocrine system; GnRH signaling pathway [PATH:ptr04912]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:ptr04915]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:ptr04921]
Organismal Systems; Endocrine system; Thyroid hormone synthesis [PATH:ptr04918]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:ptr04919]
Organismal Systems; Endocrine system; Melanogenesis [PATH:ptr04916]
Organismal Systems; Circulatory system; Adrenergic signaling in cardiomyocytes [PATH:ptr04261]
Organismal Systems; Circulatory system; Vascular smooth muscle contraction [PATH:ptr04270]
Organismal Systems; Digestive system; Salivary secretion [PATH:ptr04970]
Organismal Systems; Digestive system; Gastric acid secretion [PATH:ptr04971]
Organismal Systems; Digestive system; Pancreatic secretion [PATH:ptr04972]
Organismal Systems; Excretory system; Endocrine and other factor-regulated calcium reabsorption [PATH:ptr04961]
Organismal Systems; Nervous system; Glutamatergic synapse [PATH:ptr04724]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:ptr04725]
Organismal Systems; Nervous system; Dopaminergic synapse [PATH:ptr04728]
Organismal Systems; Nervous system; Serotonergic synapse [PATH:ptr04726]
Organismal Systems; Nervous system; Long-term potentiation [PATH:ptr04720]
Organismal Systems; Nervous system; Long-term depression [PATH:ptr04730]
Organismal Systems; Nervous system; Retrograde endocannabinoid signaling [PATH:ptr04723]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:ptr04750]
Organismal Systems; Environmental adaptation; Circadian entrainment [PATH:ptr04713]
Human Diseases; Neurodegenerative diseases; Alzheimer's disease [PATH:ptr05010]
Human Diseases; Neurodegenerative diseases; Huntington's disease [PATH:ptr05016]
Human Diseases; Infectious diseases; Amoebiasis [PATH:ptr05146]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:ptr05142]
Human Diseases; Infectious diseases; African trypanosomiasis [PATH:ptr05143]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
20
AA seq 1211 aa AA seqDB search
MGSLQGIATKILIRILSDALIRKETDLKKSTIVTPIILRTDPQGFFFYWTDQNKETELLD
LSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEE
VAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRV
ETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQM
MDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENG
VVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCW
KGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMA
EYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQ
ASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVN
YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD
SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF
TEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNP
VWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLT
LPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPG
ETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEV
EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAA
LEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYY
SEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKS
KDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVE
LEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGG
DIPGKEFDTPL
NT seq 3636 nt NT seq  +upstreamnt  +downstreamnt
atgggatccttgcagggaatcgccaccaagattttgattagaattttgtcagatgctctg
ataagaaaagaaactgacctgaaaaagtcaactattgttactccaattattttgaggact
gaccctcagggatttttcttttactggacagatcagaacaaggagacagagctactggat
ctcagccttgtcaaagatgccagatgtgggagacacgccaaagctcccaaggaccccaaa
ttacgtgaacttttggatgtggggaacatcgggcgcctggagcagcgcatgatcacagtg
gtgtatgggcctgacctcgtgaacatctcccatttgaatctcgtggctttccaagaagaa
gtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctgctggcccaaaac
atgtccagggatgcatttctggaaaaagcctatactaaacttaagctgcaagtcactcca
gaagggcgtattcctctcaaaaacatatatcgcttgttttcagcagaccggaagcgagtt
gaaactgctttagaggcttgtagtcttccatcttcaaggaatgattcaatacctcaagaa
gatttcactccagaagtgtacagagttttcctcaacaacctttgccctcgaccggaaatt
gataacatcttttcagaatttggtgccaaaagcaaaccatatcttaccgttgatcagatg
atggattttatcaaccttaagcagcgagatcctcggcttaatgaaatactttatccacct
ctaaaacaagagcaagtccaagtattgattgagaagtatgaacccaacaacagcctcgcc
agaaaaggacaaatatcagtggatgggttcatgcgctatctgagtggagaagaaaacgga
gtcgtttcacctgagaaactggatttgaatgaagacatgtctcagcccctttctcactat
ttcattaattcctcgcacaacacctacctcacagctggccaactggctggaaactcctct
gttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggagctggactgctgg
aagggacggactgcagaagaggaacctgtcattacccatggcttcaccatgacaactgaa
atatctttcaaggaagtgatagaagcaattgcggagtgtgcatttaagacttcacctttt
ccaattctcctttcgtttgagaaccatgtggattccccaaagcagcaagccaagatggcg
gagtactgccgactgatctttggggatgcccttctcatggagcccctggaaaaatatcca
ctggaatctggagttcctcttccaagccctatggatttaatgtataaaattttggtgaaa
aataagaagaaatcacacaagtcatcagaaggaagcggcaaaaagaagctctcagaacaa
gcctccaacacctacagtgactcctccagcatgttcgagccctcatccccaggagccgga
gaagctgatacggaaagtgacgatgacgacgatgatgatgactgtaaaaaatcttcaatg
gatgaggggactgctggaagtgaggctatggccacagaagaaatgtctaatctggtgaac
tatattcagccagtcaagtttgagtcatttgaaatttcaaaaaaaagaaataaaagtttt
gaaatgtcttccttcgtggaaaccaaaggacttgaacaactcaccaagtctccagtggaa
tttgtagaatataacaaaatgcagcttagcaggatatatccaaaaggaacacgtgtggat
tcatccaactatatgcctcagctcttctggaatgcaggttgtcagatggtggcacttaat
ttccagacaatggacctggctatgcaaataaatatggggatgtatgaatacaacgggaag
agtggctacagattgaagccagagttcatgaggaggcctgacaagcattttgatccattt
actgaaggcatcgtagatgggatagtggcaaacactttgtctgttaagattatttcaggt
cagtttctttctgataagaaagttgggacttacgtggaagtggatatgttcggtttgcct
gtggatacaaggaggaaggcatttaagaccaaaacatcccaaggaaatgctgtgaatcct
gtctgggaggaagaacctattgtgttcaaaaaggtggttcttcctactctggcctgtttg
agaatagcagtttatgaagaaggaggtaaattcattggccaccgtatcttgccagtgcaa
gccattcggccaggctatcactatatctgtctaaggaatgaaaggaaccagcctctgacg
ctgcctgctgtctttgtctacatagaagtgaaagactatgtgccagacacatatgcagat
gtcatcgaagctttatcaaacccaatccgatatgtgaacctgatggaacagagagctaag
caattggctgctttgacactggaagatgaagaagaagtaaagaaagaggctgatcctgga
gaaacaccatcagaggctccaagtgaagcgagaacgactccagcagaaaatggggtgaat
cacactacaaccctgacacccaagccaccctcccaggctctccacagccagccagctcca
ggttctgtaaaggcacctgccaaaacagaggatcttattcagagtgtcttaacagaagtg
gaagcacagaccatcgaagaactaaagcaacagaaatcgtttgtgaaacttcaaaagaaa
cactacaaagaaatgaaagacctggttaagagacaccacaagaaaaccactgaccttatc
aaagaacacactaccaagtataatgaaattcagaatgactacttgagaaggagagcagct
ttggaaaagtccgccaaaaaggacagtaagaaaaaatcggaacccagcagccctgatcat
ggttcatcaacgattgagcaagacctcgctgccctggatgctgaaatgacccaaaagtta
atagacttgaaggacaaacaacagcagcagctgcttaatcttcggcaagaacagtattat
agtgaaaaataccagaagcgagaacatattaaactgcttattcaaaagttgacggatgtc
gcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatctgtgagaaagaaaag
aaagaattaaagaagaaaatggataaaaagaggcaggagaagataacagaagctaaatcc
aaagacaaaagtcagatggaagaggagaagacagagatgatccggtcatatatccaggaa
gtggtgcagtatatcaagaggctagaagaagcgcaaagtaaacggcaagaaaaactcgta
gagaaacacaaggaaatacgtcagcagatcctggatgaaaagcccaagctgcaggtggag
ctggagcaagaataccaagacaaattcaaaagactgcccctcgagattttggaattcgtg
caggaagccatgaaaggaaagatcagtgaagacagcaatcacggttctgcccctctctcc
ctgtcctcagaccctggaaaagtgaaccacaagactccctccagtgaggagctgggagga
gacatcccaggaaaagaatttgatactcctctgtga

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