KEGG   Pan troglodytes (chimpanzee): 741350
Entry
741350            CDS       T01005                                 
Symbol
PRKN
Name
(RefSeq) E3 ubiquitin-protein ligase parkin isoform X1
  KO
K04556  parkin [EC:2.3.2.31]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr04120  Ubiquitin mediated proteolysis
ptr04137  Mitophagy - animal
ptr04141  Protein processing in endoplasmic reticulum
ptr05012  Parkinson disease
ptr05014  Amyotrophic lateral sclerosis
ptr05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ptr00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    741350 (PRKN)
   04120 Ubiquitin mediated proteolysis
    741350 (PRKN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    741350 (PRKN)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    741350 (PRKN)
   05014 Amyotrophic lateral sclerosis
    741350 (PRKN)
   05022 Pathways of neurodegeneration - multiple diseases
    741350 (PRKN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptr04131]
    741350 (PRKN)
   04121 Ubiquitin system [BR:ptr04121]
    741350 (PRKN)
   03029 Mitochondrial biogenesis [BR:ptr03029]
    741350 (PRKN)
Enzymes [BR:ptr01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     741350 (PRKN)
Membrane trafficking [BR:ptr04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    741350 (PRKN)
  Aggrephagy
   Other aggrephagy associated proteins
    741350 (PRKN)
  Xenophagy
   Other xenophagy associated proteins
    741350 (PRKN)
Ubiquitin system [BR:ptr04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    741350 (PRKN)
Mitochondrial biogenesis [BR:ptr03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    741350 (PRKN)
SSDB
Motif
Pfam: zf-RING_14 zf-RING_12 ubiquitin IBR Rad60-SLD Rad60-SLD_2 Dsc3_N Crinkler
Other DBs
NCBI-GeneID: 741350
NCBI-ProteinID: XP_001153913
Ensembl: ENSPTRG00000018781
VGNC: 13029
UniProt: A0A6D2XY08 H2QU08
Position
6:complement(158848074..160231167)
AA seq 465 aa
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQHCD
LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA
VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCGQATLTLTQGP
SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT
CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE
LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC
GFAFCRECKEAYHEGECSALFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR
CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
NT seq 1398 nt   +upstreamnt  +downstreamnt
atgatagtgtttgtcaggttcaactccagccatggtttcccagtggaggtcgattctgac
accagcatcttccagctcaaggaggtggttgctaagcgacagggggttccggctgaccag
ttgcgtgtgattttcgcagggaaggagctgaggaatgactggactgtgcagcattgtgac
ctggatcagcagagcattgttcacattgtgcagagaccgtggagaaaaggtcaagaaatg
aatgcaactggaggcgacgaccccagaaacgcggcgggaggctgtgagcgggagccccag
agcttgactcgggtggacctcagcagctcagtcctcccaggagactctgtggggctggct
gtcattctgcacactgacagcaggaaggactcaccaccagctggaagtccagcaggtaga
tcaatctacaacagcttttatgtgtattgcaaaggcccctgtcaaagagtgcagccggga
aaactcagggtacagtgcagcacctgcgggcaggcaacgctcaccttgacccagggtcca
tcttgctgggatgatgttttaattccaaaccggatgagtggtgaatgccaatccccacac
tgccctgggactagtgcagaatttttctttaaatgtggagcacaccccacctctgacaag
gaaacatcagtagctttgcacctgatcgcaacaaatagtcggaacatcacttgcattacg
tgcacagacgtcaggagccccgtcctggttttccagtgcaactcccgccacgtgatttgc
ttagactgtttccacttatactgtgtgacaagactcaatgatcggcagtttgttcacgac
cctcaacttggctactccctgccttgtgtggctggctgtcccaactccttgattaaagag
ctccatcacttcaggattctgggagaagagcagtacaaccggtaccagcagtatggtgca
gaggagtgtgtcctgcagatggggggcgtgttatgcccccgccctggctgtggagcgggg
ctgctgccggagcctgaccagaggaaagtcacctgcgaagggggcaatggcctgggctgt
gggtttgccttctgccgggaatgtaaagaagcgtaccatgaaggggagtgcagtgcccta
tttgaagcctcaggaacaactactcaggcctacagagtcgatgaaagagccgcagagcag
gctcgttgggaagcagcctccaaagaaaccatcaagaaaaccaccaagccctgtccccgc
tgccatgtaccagtggaaaaaaatggaggctgcatgcacatgaagtgtccacagccccag
tgcaggctcgagtggtgctggaactgtggctgcgagtggaaccgcgtctgcatgggggac
cactggttcgacgtgtag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (8)   
   UniProt (2)   
   RefSeq(pep) (6)   
DNA sequence (8)   
   RefSeq(nuc) (6)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   Pfam (8)   
All databases (43)   

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