Database: PubMedEntry: 11337471
Original site: 11337471
Bolotin A, Wincker P, Mauger S, Jaillon O, Malarme K, Weissenbach J,
Ehrlich SD, Sorokin A.
The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp.
Genome Res. 2001 May;11(5):731-53.
Lactococcus lactis is a nonpathogenic AT-rich gram-positive bacterium closely
related to the genus Streptococcus and is the most commonly used cheese starter.
It is also the best-characterized lactic acid bacterium. We sequenced the genome
of the laboratory strain IL1403, using a novel two-step strategy that comprises
diagnostic sequencing of the entire genome and a shotgun polishing step. The
genome contains 2,365,589 base pairs and encodes 2310 proteins, including 293
protein-coding genes belonging to six prophages and 43 insertion sequence (IS)
elements. Nonrandom distribution of IS elements indicates that the chromosome of
the sequenced strain may be a product of recent recombination between two closely
related genomes. A complete set of late competence genes is present, indicating
the ability of L. lactis to undergo DNA transformation. Genomic sequence revealed
new possibilities for fermentation pathways and for aerobic respiration. It also
indicated a horizontal transfer of genetic information from Lactococcus to
gram-negative enteric bacteria of Salmonella-Escherichia group.
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