Database: PubMed
Entry: 12470645
LinkDB: 12470645
Original site: 12470645 

PMID:
     12470645
Authors:
     Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW.
Title:
     Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its
     overexpression condenses the Rab11 positive compartment in HeLa cells.
Journal:
     Biochem Biophys Res Commun. 2002 Dec 20;299(5):770-9.
Abstract:
     We have recently identified Rab11-FIP4 as the sixth member of the
     Rab11-FIP family of Rab11 interacting proteins. Here, we demonstrate that
     Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and that its
     C-terminal region allows the protein to self-interact and interact with
     pp75/Rip11, Rab11-FIP2, and Rab11-FIP3. However, Rab11-FIP4 does not
     appear to interact directly with Rab coupling protein (RCP). We
     investigated the subcellular localisation of Rab11-FIP4 in HeLa cells and
     show that it colocalises extensively with transferrin and with Rab11.
     Furthermore, when overexpressed, it causes a condensation of the Rab11
     compartment in the perinuclear region. We demonstrate that the
     carboxy-terminal region of Rab11-FIP4 (Rab11-FIP4(C-ter)) is necessary and
     sufficient for its endosomal membrane association. Expression of
     Rab11-FIP4(C-ter) causes a dispersal of the Rab11 compartment towards the
     cell periphery and does not inhibit transferrin recycling in HeLa cells.
     It is likely that Rab11-FIP4 serves as a Rab11 effector in a Rab11
     mediated function other than transferrin recycling.

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