Seshadri R, Joseph SW, Chopra AK, Sha J, Shaw J, Graf J,
Haft D, Wu M, Ren Q, Rosovitz MJ, Madupu R, Tallon L,
Kim M, Jin S, Vuong H, Stine OC, Ali A, Horneman AJ,
Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.
J Bacteriol. 2006 Dec;188(23):8272-82. doi: 10.1128/JB.00621-06. Epub 2006 Sep
The complete genome of Aeromonas hydrophila ATCC 7966(T) was sequenced.
Aeromonas, a ubiquitous waterborne bacterium, has been placed by the
Environmental Protection Agency on the Contaminant Candidate List because of its
potential to cause human disease. The 4.7-Mb genome of this emerging pathogen
shows a physiologically adroit organism with broad metabolic capabilities and
considerable virulence potential. A large array of virulence genes, including
some identified in clinical isolates of Aeromonas spp. or Vibrio spp., may confer
upon this organism the ability to infect a wide range of hosts. However, two
recognized virulence markers, a type III secretion system and a lateral
flagellum, that are reported in other A. hydrophila strains are not identified in
the sequenced isolate, ATCC 7966(T). Given the ubiquity and free-living lifestyle
of this organism, there is relatively little evidence of fluidity in terms of
mobile elements in the genome of this particular strain. Notable aspects of the
metabolic repertoire of A. hydrophila include dissimilatory sulfate reduction and
resistance mechanisms (such as thiopurine reductase, arsenate reductase, and
phosphonate degradation enzymes) against toxic compounds encountered in polluted
waters. These enzymes may have bioremediative as well as industrial potential.
Thus, the A. hydrophila genome sequence provides valuable insights into its
ability to flourish in both aquatic and host environments.
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