PMID:
     16980456
Authors:
     Seshadri R, Joseph SW, Chopra AK, Sha J, Shaw J, Graf J,
     Haft D, Wu M, Ren Q, Rosovitz MJ, Madupu R, Tallon L,
     Kim M, Jin S, Vuong H, Stine OC, Ali A, Horneman AJ,
     Heidelberg JF.
Title:
     Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.
Journal:
     J Bacteriol. 2006 Dec;188(23):8272-82. Epub 2006 Sep 15.
Abstract:
     The complete genome of Aeromonas hydrophila ATCC 7966(T) was sequenced.
     Aeromonas, a ubiquitous waterborne bacterium, has been placed by the
     Environmental Protection Agency on the Contaminant Candidate List because of its 
     potential to cause human disease. The 4.7-Mb genome of this emerging pathogen
     shows a physiologically adroit organism with broad metabolic capabilities and
     considerable virulence potential. A large array of virulence genes, including
     some identified in clinical isolates of Aeromonas spp. or Vibrio spp., may confer
     upon this organism the ability to infect a wide range of hosts. However, two
     recognized virulence markers, a type III secretion system and a lateral
     flagellum, that are reported in other A. hydrophila strains are not identified in
     the sequenced isolate, ATCC 7966(T). Given the ubiquity and free-living lifestyle
     of this organism, there is relatively little evidence of fluidity in terms of
     mobile elements in the genome of this particular strain. Notable aspects of the
     metabolic repertoire of A. hydrophila include dissimilatory sulfate reduction and
     resistance mechanisms (such as thiopurine reductase, arsenate reductase, and
     phosphonate degradation enzymes) against toxic compounds encountered in polluted 
     waters. These enzymes may have bioremediative as well as industrial potential.
     Thus, the A. hydrophila genome sequence provides valuable insights into its
     ability to flourish in both aquatic and host environments.

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