KEGG   REACTION: R00256Help
Entry
R00256                      Reaction                               

Name
L-glutamine amidohydrolase
Definition
L-Glutamine + H2O <=> L-Glutamate + Ammonia
Equation
Comment
the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor
ec 6.3.5.4 (see R00578, R00256+R00483)
ec 6.3.5.5 (see R00575, R00256+R07641)
RPair
C00025_C00064 main [RC:RC00010]
C00001_C00025 leave
C00014_C00064 main [RC:RC02798]
Enzyme
1.4.1.13        1.4.7.1         3.5.1.2         3.5.1.38        
4.3.3.6         6.3.4.2         6.3.5.2         6.3.5.4         
6.3.5.5
Pathway
Alanine, aspartate and glutamate metabolism
Arginine and proline metabolism
D-Glutamine and D-glutamate metabolism
Metabolic pathways
Orthology
K01425  
glutaminase [EC:3.5.1.2]
K05597  
glutamin-(asparagin-)ase [EC:3.5.1.38]

KEGG   REACTION: R00483Help
Entry
R00483                      Reaction                               

Name
L-aspartate:ammonia ligase (AMP-forming)
Definition
ATP + L-Aspartate + Ammonia <=> AMP + Diphosphate + L-Asparagine
Equation
Comment
second step of multi-step reaction (ec 6.3.5.4, see R00578, R00256+R00483)
RPair
C00002_C00020 ligase
C00002_C00013 ligase
C00049_C00152 main [RC:RC00010]
C00014_C00152 leave [RC:RC02798]
Enzyme
6.3.1.1         6.3.5.4
Pathway
Alanine, aspartate and glutamate metabolism
Cyanoamino acid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of amino acids
Orthology
K01914  
aspartate--ammonia ligase [EC:6.3.1.1]

KEGG   REACTION: R00578Help
Entry
R00578                      Reaction                               

Name
L-aspartate:L-glutamine amido-ligase (AMP-forming)
Definition
ATP + L-Aspartate + L-Glutamine + H2O <=> AMP + Diphosphate + L-Asparagine + L-Glutamate
Equation
Comment
two-step reaction (see R00256+R00483)
RPair
C00002_C00020 ligase
C00002_C00013 ligase
C00025_C00064 main [RC:RC00010]
C00049_C00152 main [RC:RC00010]
C00001_C00025 leave
C00064_C00152 trans
Enzyme
Pathway
Alanine, aspartate and glutamate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01953  
asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]

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