KEGG   REACTION: R00424Help
Entry
R00424                      Reaction                               

Name
GTP 7,8-8,9-dihydrolase
Definition
GTP + H2O <=> 7,8-Dihydroneopterin 3'-triphosphate + Formate
Equation
Comment
four-step reaction (see R00428+R05046+R05048+R04639)
RPair
C00044_C00058 main
C00044_C04895 main
C00001_C00058 leave
Enzyme

KEGG   REACTION: R00428Help
Entry
R00428                      Reaction                               

Name
GTP 8,9-hydrolase
Definition
GTP + H2O <=> Formamidopyrimidine nucleoside triphosphate
Equation
Comment
the first step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
subsequently R05046
RPair
C00044_C05922 main
Enzyme
Pathway
Folate biosynthesis
Metabolic pathways
Orthology
K01495  
GTP cyclohydrolase I [EC:3.5.4.16]
K09007  
GTP cyclohydrolase I [EC:3.5.4.16]

KEGG   REACTION: R04639Help
Entry
R04639                      Reaction                               

Name
2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate hydrolase
Definition
7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Equation
Comment
the last step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
possibly spontaneous
following after R05048
RPair
C04895_C06148 main
C00001_C06148 leave
Enzyme
Pathway
Folate biosynthesis
Metabolic pathways
Orthology
K01495  
GTP cyclohydrolase I [EC:3.5.4.16]
K09007  
GTP cyclohydrolase I [EC:3.5.4.16]

KEGG   REACTION: R05046Help
Entry
R05046                      Reaction                               

Name
formamidopyrimidine nucleoside triphosphate amidohydrolase
Definition
Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate
Equation
Comment
the second step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
following after R00428
subsequently R05048
RPair
C05922_C05923 main
C00058_C05922 main
C00001_C00058 leave
Enzyme
Pathway
Folate biosynthesis
Metabolic pathways
Orthology
K01495  
GTP cyclohydrolase I [EC:3.5.4.16]
K09007  
GTP cyclohydrolase I [EC:3.5.4.16]

KEGG   REACTION: R05048Help
Entry
R05048                      Reaction                               

Name
2,5-diaminopyrimidine nucleoside triphosphate mutase
Definition
2,5-Diaminopyrimidine nucleoside triphosphate <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Equation
Comment
the third step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
maybe spontaneous (Amadori rearrangement)
following after R05046
subsequently R04639
RPair
C05923_C06148 main
Enzyme
Pathway
Folate biosynthesis
Metabolic pathways
Orthology
K01495  
GTP cyclohydrolase I [EC:3.5.4.16]
K09007  
GTP cyclohydrolase I [EC:3.5.4.16]

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