KEGG   REACTION: R00630Help
Entry
R00630                      Reaction                               

Name
Carboxylic-ester hydrolase
Definition
Ester + H2O <=> Alcohol + Carboxylate
Equation
Comment
general reaction
RPair
C00060_C02391 main [RC:RC00342]
C00069_C02391 main [RC:RC00339]
C00001_C00060 leave
Enzyme

KEGG   REACTION: R06728Help
Entry
R06728                      Reaction                               

Name
cocaine benzoylhydrolase
Definition
Cocaine + H2O <=> Ecgonine methyl ester + Benzoate
Equation
Comment
cocaine esterase
RPair
C00001_C00180 leave
C00180_C01416 main [RC:RC00523]
C01416_C12448 main [RC:RC00055]
Enzyme
3.1.1.1         3.1.1.84
Pathway
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01044  
carboxylesterase 1 [EC:3.1.1.1]

KEGG   REACTION: R08255Help
Entry
R08255                      Reaction                               

Definition
Irinotecan + H2O <=> SN-38 + 1,4'-Bipiperidine-1'-carboxylic acid
Equation
Comment
carboxylesterase
RPair
C11173_C16641 main [RC:RC00476]
C16641_C16836 main [RC:RC00475]
C00001_C16836 leave
Enzyme
Pathway
Drug metabolism - other enzymes
Orthology
K01044  
carboxylesterase 1 [EC:3.1.1.1]
K03927  
carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]

KEGG   REACTION: R08258Help
Entry
R08258                      Reaction                               

Definition
NPC + H2O <=> SN-38 + 4-Amino-1-piperidinecarboxylic acid
Equation
Comment
carboxylesterase
RPair
C11173_C16543 main [RC:RC00476]
C16543_C16837 main [RC:RC00475]
C00001_C16837 leave
Enzyme
Pathway
Drug metabolism - other enzymes
Orthology
K01044  
carboxylesterase 1 [EC:3.1.1.1]
K03927  
carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]

KEGG   REACTION: R08220Help
Entry
R08220                      Reaction                               

Name
capecitabine hydrolase
Definition
Capecitabine + H2O <=> 5'-Deoxy-5-fluorocytidine + 1-Pentanol + CO2
Equation
Comment
multi-step reaction
RPair
C00001_C00011 leave
C12650_C16635 main [RC:RC02264]
C12650_C16834 main [RC:RC00041]
C00011_C12650 leave
Enzyme
Pathway
Drug metabolism - other enzymes
Orthology
K01044  
carboxylesterase 1 [EC:3.1.1.1]
K03927  
carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]

KEGG   REACTION: R08295Help
Entry
R08295                      Reaction                               

Name
Monoethylglycinexylidide amidohydrolase
Definition
Monoethylglycinexylidide + H2O <=> 2,6-Dimethylaniline + N-Ethylglycine
Equation
Comment
carboxylesterases (ec 3.1.1.1) also have some amidohydrolase activities
RPair
C11004_C16561 main [RC:RC00416]
C11735_C16561 main [RC:RC00090]
C00001_C11735 leave
Enzyme
Pathway
Drug metabolism - cytochrome P450

KEGG   REACTION: R08300Help
Entry
R08300                      Reaction                               

Name
Lidocaine amidohydrolase
Definition
Lidocaine + H2O <=> 2,6-Dimethylaniline + N,N-Diethylglycine
Equation
Comment
carboxylesterases (ec 3.1.1.1) also have some amidohydrolase activities
RPair
C00001_C16647 leave
C07073_C11004 main [RC:RC00416]
C07073_C16647 main [RC:RC00090]
Enzyme
Pathway
Drug metabolism - cytochrome P450

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