KEGG   REACTION: R00922
Entry
R00922                      Reaction                               
Name
2-methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)
Definition
2-Methyl-3-oxopropanoate + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+
Equation
C00349 + C00010 + C00003 <=> C00100 + C00011 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00100
Enzyme
1.2.1.27
Pathway
rn00280  Valine, leucine and isoleucine degradation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.27
     R00922  2-Methyl-3-oxopropanoate + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.2.1.27
   R00922  2-Methyl-3-oxopropanoate
Orthology
K00140  malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]
Other DBs
RHEA: 20807

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (7326)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (7325)   
All databases (7340)   

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KEGG   REACTION: R00935
Entry
R00935                      Reaction                               
Name
(S)-methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating)
Definition
(S)-Methylmalonate semialdehyde + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+
Equation
C06002 + C00010 + C00003 <=> C00100 + C00011 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00100
RC02817  C00100_C06002
Enzyme
1.2.1.27
Pathway
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.27
     R00935  (S)-Methylmalonate semialdehyde + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.2.1.27
   R00922  2-Methyl-3-oxopropanoate
    R00935  (S)-Methylmalonate semialdehyde
Orthology
K00140  malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]
Other DBs
RHEA: 31050

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
   SABIO-RK (1)   
Gene (7326)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (7325)   
All databases (7344)   

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KEGG   REACTION: R00705
Entry
R00705                      Reaction                               
Name
3-oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating)
Definition
3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Equation
C00222 + C00010 + C00003 <=> C00024 + C00011 + C00004 + C00080
Comment
NADP+ (ec 1.2.1.18, see R00706)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00024
RC02723  C00024_C00222
Enzyme
1.2.1.18        1.2.1.27
Pathway
rn00410  beta-Alanine metabolism
rn00562  Inositol phosphate metabolism
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
rn01200  Carbon metabolism
Module
M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.18
     R00705  3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
    1.2.1.27
     R00705  3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
Orthology
K00140  malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]
Other DBs
RHEA: 22995

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (11)   
   KEGG PATHWAY (10)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG RCLASS (3)   
   SABIO-RK (1)   
Gene (7326)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (7325)   
All databases (7351)   

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