KEGG   REACTION: R00939Help
Entry
R00939                      Reaction                               

Name
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Definition
Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+
Equation
Comment
NADH (see R00936)
RPair
C00005_C00006 cofac [RC:RC00001]
C00101_C00415 main [RC:RC00109]
Enzyme
Pathway
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Module
M00126  
Tetrahydrofolate biosynthesis, GTP => THF
Orthology
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K13938  
dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.- 1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

KEGG   REACTION: R00936Help
Entry
R00936                      Reaction                               

Name
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Definition
Tetrahydrofolate + NAD+ <=> Dihydrofolate + NADH + H+
Equation
Comment
NADPH (see R00939)
RPair
C00003_C00004 cofac [RC:RC00001]
C00101_C00415 main [RC:RC00109]
Enzyme
Pathway
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Module
M00126  
Tetrahydrofolate biosynthesis, GTP => THF
Orthology
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K13938  
dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.- 1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

KEGG   REACTION: R00937Help
Entry
R00937                      Reaction                               

Name
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Definition
Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
Equation
C00101 + 2 C00003 <=> C00504 + 2 C00004 + 2 C00080
Comment
two-step reaction (see R00936+R02235)
NADP+ (see R00940)
RPair
C00003_C00004 cofac [RC:RC00001]
C00101_C00504 main [RC:RC00110]
Enzyme
Pathway
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Orthology
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

KEGG   REACTION: R00940Help
Entry
R00940                      Reaction                               

Name
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Definition
Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
Equation
C00101 + 2 C00006 <=> C00504 + 2 C00005 + 2 C00080
Comment
two-step reaction (see R00939+R02236)
NAD+ (see R00937)
RPair
C00005_C00006 cofac [RC:RC00001]
C00101_C00504 main [RC:RC00110]
Enzyme
Pathway
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Orthology
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

KEGG   REACTION: R02235Help
Entry
R02235                      Reaction                               

Name
dihydrofolate:NAD+ oxidoreductase
Definition
Dihydrofolate + NAD+ <=> Folate + NADH + H+
Equation
RPair
C00003_C00004 cofac [RC:RC00001]
C00415_C00504 main [RC:RC00158]
Enzyme
Pathway
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Orthology
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

KEGG   REACTION: R02236Help
Entry
R02236                      Reaction                               

Name
dihydrofolate:NADP+ oxidoreductase
Definition
Dihydrofolate + NADP+ <=> Folate + NADPH + H+
Equation
RPair
C00005_C00006 cofac [RC:RC00001]
C00415_C00504 main [RC:RC00158]
Enzyme
Pathway
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Orthology
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

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