KEGG   REACTION: R02724
Entry
R02724                      Reaction                               
Name
cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Definition
Cholesterol + 3 Oxygen + 6 H+ + 6 Reduced adrenal ferredoxin <=> 4-Methylpentanal + Pregnenolone + 4 H2O + 6 Oxidized adrenal ferredoxin
Equation
C00187 + 3 C00007 + 6 C00080 + 6 C00662 <=> C02373 + C01953 + 4 C00001 + 6 C00667
Comment
three-step reaction (R01454+R04854+R03933 or R02723+R04855+R03933)
Reaction class
RC00774  C00187_C01953
RC00775  C00187_C02373
Enzyme
1.14.15.6
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R02724  Cholesterol + 3 Oxygen + 6 H+ + 6 Reduced adrenal ferredoxin <=> 4-Methylpentanal + Pregnenolone + 4 H2O + 6 Oxidized adrenal ferredoxin
Other DBs
RHEA: 35742

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Ontology (1)   
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Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
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KEGG   REACTION: R01454
Entry
R01454                      Reaction                               
Name
cholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
Cholesterol + Oxygen + 2 H+ + 2 Reduced adrenal ferredoxin <=> 20alpha-Hydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C00187 + C00007 + 2 C00080 + 2 C00662 <=> C05500 + C00001 + 2 C00667
Comment
first step of R02724 (R01454+R04854+R03933)
Reaction class
RC00521  C00187_C05500
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R01454  Cholesterol + Oxygen + 2 H+ + 2 Reduced adrenal ferredoxin <=> 20alpha-Hydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

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Ontology (1)   
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Pathway (5)   
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   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (393)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (392)   
All databases (408)   

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KEGG   REACTION: R02723
Entry
R02723                      Reaction                               
Definition
Cholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 22(R)-Hydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C00187 + C00007 + 2 C00662 + 2 C00080 <=> C05502 + C00001 + 2 C00667
Comment
first step of R02724 (R02723+R04855+R03933)
Reaction class
RC00773  C00187_C05502
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R02723  Cholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 22(R)-Hydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Other DBs
RHEA: 34338

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (393)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (392)   
All databases (408)   

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KEGG   REACTION: R03933
Entry
R03933                      Reaction                               
Name
20alpha,22beta-dihydroxycholesterol,ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Definition
20alpha,22beta-Dihydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 4-Methylpentanal + Pregnenolone + 2 H2O + 2 Oxidized adrenal ferredoxin
Equation
C05501 + C00007 + 2 C00662 + 2 C00080 <=> C02373 + C01953 + 2 C00001 + 2 C00667
Comment
third step of R02724 (R01454+R04854+R03933 or R02723+R04855+R03933)
Reaction class
RC01029  C01953_C05501
RC01030  C02373_C05501
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R03933  20alpha,22beta-Dihydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 4-Methylpentanal + Pregnenolone + 2 H2O + 2 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Other DBs
RHEA: 34346

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (393)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (392)   
All databases (410)   

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KEGG   REACTION: R04676
Entry
R04676                      Reaction                               
Name
17alpha,20alpha-dihydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
17alpha,20alpha-Dihydroxycholesterol + 2 Oxygen + 4 H+ + 4 Reduced adrenal ferredoxin <=> 17alpha-Hydroxypregnenolone + 4-Methylpentanal + 3 H2O + 4 Oxidized adrenal ferredoxin
Equation
C05499 + 2 C00007 + 4 C00080 + 4 C00662 <=> C05138 + C02373 + 3 C00001 + 4 C00667
Comment
two-step reaction (similar to R04854+R03933)
Reaction class
RC01193  C05138_C05499
RC01543  C02373_C05499
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R04676  17alpha,20alpha-Dihydroxycholesterol + 2 Oxygen + 4 H+ + 4 Reduced adrenal ferredoxin <=> 17alpha-Hydroxypregnenolone + 4-Methylpentanal + 3 H2O + 4 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (393)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (392)   
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KEGG   REACTION: R04854
Entry
R04854                      Reaction                               
Name
20alpha-hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
20alpha-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C05500 + C00007 + 2 C00662 + 2 C00080 <=> C05501 + C00001 + 2 C00667
Comment
second step of R02724 (R01454+R04854+R03933)
Reaction class
RC01223  C05500_C05501
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R04854  20alpha-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
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Gene (393)   
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KEGG   REACTION: R04855
Entry
R04855                      Reaction                               
Name
22beta-hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)
Definition
22(R)-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Equation
C05502 + C00007 + 2 C00662 + 2 C00080 <=> C05501 + C00001 + 2 C00667
Comment
second step of R02724 (R02723+R04855+R03933)
Reaction class
RC00706  C05501_C05502
Enzyme
1.14.15.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6
     R04855  22(R)-Hydroxycholesterol + Oxygen + 2 Reduced adrenal ferredoxin + 2 H+ <=> 20alpha,22beta-Dihydroxycholesterol + H2O + 2 Oxidized adrenal ferredoxin
Orthology
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Other DBs
RHEA: 34342

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (393)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (392)   
All databases (408)   

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