KEGG REACTION: R02810

REACTION: R02810

Entry

R02810 Reaction

Name

iodide:hydrogen-peroxide oxidoreductase

Definition

2 Iodide + Hydrogen peroxide + 2 H+ <=> Iodine + 2 H2O

Equation

2 C00708 + C00027 + 2 C00080 <=> C01382 + 2 C00001

Comment

thyroid peroxidase, TPO
multi-step reaction on thyroglobulin [KO:K10809] (see R02810+R08520+R08521+R08522+R08523)

RPair

RP00130	C00001_C00027 cofac
RP02521	C00708_C01382 main

Enzyme

1.11.1.8

All links

Ontology (1)   
   KEGG BRITE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
   KEGG RPAIR (2)   
   KEGG RCLASS (1)   
Gene (1)   
   KEGG ORTHOLOGY (1)   
All databases (15)   

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REACTION: R03208

Entry

R03208 Reaction

Definition

2 3,5-Diiodo-L-tyrosine + Hydrogen peroxide <=> Thyroxine + Dehydroalanine + 2 H2O

Equation

2 C01060 + C00027 <=> C01829 + C02218 + 2 C00001

Comment

thyroid peroxidase, TPO
reaction on thyroglobulin [KO:K10809] (see R08523)

RPair

RP00130	C00001_C00027 cofac
RP02842	C01060_C01829 main
RP02843	C01060_C02218 main
RP14649	C01060_C01829 trans

Enzyme

1.11.1.8

Pathway

rn00350	Tyrosine metabolism
rn01100	Metabolic pathways

Orthology

K00431

thyroid peroxidase [EC:1.11.1.8]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RPAIR (4)   
   KEGG RCLASS (2)   
Gene (33)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (31)   
All databases (51)   

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REACTION: R03539

Entry

R03539 Reaction

Definition

Hydroiodic acid + 3-Iodo-L-tyrosine <=> Iodine + L-Tyrosine

Equation

C05590 + C02515 <=> C01382 + C00082

Comment

thyroid peroxidase, TPO
reaction on thyroglobulin [KO:K10809] (see R08520)

RPair

RP03153	C00082_C02515 main
RP07586	C01382_C02515 leave
RP10512	C01382_C05590 leave

Enzyme

1.11.1.8

Pathway

rn00350	Tyrosine metabolism
rn01100	Metabolic pathways

Orthology

K00431

thyroid peroxidase [EC:1.11.1.8]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (32)   
   KEGG PATHWAY (4)   
   KEGG MODULE (28)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RPAIR (3)   
   KEGG RCLASS (1)   
Gene (33)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (31)   
All databases (76)   

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REACTION: R03953

Entry

R03953 Reaction

Definition

3-Iodo-L-tyrosine + 3,5-Diiodo-L-tyrosine + Hydrogen peroxide <=> Triiodothyronine + Dehydroalanine + 2 H2O

Equation

C02515 + C01060 + C00027 <=> C02465 + C02218 + 2 C00001

Comment

thyroid peroxidase, TPO
reaction on thyroglobulin [KO:K10809] (see R08522)

RPair

RP00130	C00001_C00027 cofac
RP03572	C01060_C02465 main
RP03573	C02218_C02515 main
RP07808	C02465_C02515 trans

Enzyme

1.11.1.8

Pathway

rn00350	Tyrosine metabolism
rn01100	Metabolic pathways

Orthology

K00431

thyroid peroxidase [EC:1.11.1.8]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (32)   
   KEGG PATHWAY (4)   
   KEGG MODULE (28)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RPAIR (4)   
   KEGG RCLASS (2)   
Gene (33)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (31)   
All databases (80)   

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REACTION: R03973

Entry

R03973 Reaction

Definition

Hydroiodic acid + 3,5-Diiodo-L-tyrosine <=> 3-Iodo-L-tyrosine + Iodine

Equation

C05590 + C01060 <=> C02515 + C01382

Comment

thyroid peroxidase, TPO
reaction on thyroglobulin [KO:K10809] (see R08521)

RPair

RP03590	C01060_C02515 main
RP07819	C01060_C01382 leave
RP10512	C01382_C05590 leave

Enzyme

1.11.1.8

Pathway

rn00350	Tyrosine metabolism
rn01100	Metabolic pathways

Orthology

K00431

thyroid peroxidase [EC:1.11.1.8]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (32)   
   KEGG PATHWAY (4)   
   KEGG MODULE (28)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RPAIR (3)   
   KEGG RCLASS (1)   
Gene (33)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (31)   
All databases (76)   

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REACTION: R08520

Entry

R08520 Reaction

Definition

Thyroglobulin L-tyrosine + Iodine <=> Thyroglobulin 3-iodotyrosine + Hydroiodic acid

Equation

C16733 + C01382 <=> C16732 + C05590

Comment

thyroid peroxidase, TPO
following after R02810
subsequently R08521 or R08522

RPair

RP10512	C01382_C05590 leave
RP12716	C16732_C16733 main
RP12717	C01382_C16732 leave

Enzyme

1.11.1.8

All links

Ontology (1)   
   KEGG BRITE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (9)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
   KEGG RPAIR (3)   
   KEGG RCLASS (1)   
All databases (14)   

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REACTION: R08521

Entry

R08521 Reaction

Definition

Thyroglobulin 3-iodotyrosine + Iodine <=> Thyroglobulin 3,5-diiodotyrosine + Hydroiodic acid

Equation

C16732 + C01382 <=> C16731 + C05590

Comment

thyroid peroxidase, TPO
following after R02810 and R08520
subsequently R08522 or R08523

RPair

RP10512	C01382_C05590 leave
RP12718	C16731_C16732 main
RP12719	C01382_C16731 leave

Enzyme

1.11.1.8

All links

Ontology (1)   
   KEGG BRITE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (10)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
   KEGG RPAIR (3)   
   KEGG RCLASS (1)   
All databases (15)   

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REACTION: R08522

Entry

R08522 Reaction

Definition

Thyroglobulin 3,5-diiodotyrosine + Thyroglobulin 3-iodotyrosine + Hydrogen peroxide <=> Thyroglobulin triiodothyronine + Thyroglobulin dehydroalanine + 2 H2O

Equation

C16731 + C16732 + C00027 <=> C16730 + C16734 + 2 C00001

Comment

thyroid peroxidase, TPO
following after R08520 and R08521

RPair

RP00130	C00001_C00027 cofac
RP12720	C16730_C16731 main
RP12721	C16732_C16734 main
RP12722	C16730_C16732 trans

Enzyme

1.11.1.8

All links

Ontology (1)   
   KEGG BRITE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (11)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
   KEGG RPAIR (4)   
   KEGG RCLASS (2)   
All databases (18)   

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REACTION: R08523

Entry

R08523 Reaction

Definition

2 Thyroglobulin 3,5-diiodotyrosine + Hydrogen peroxide <=> Thyroglobulin L-thyroxine + Thyroglobulin dehydroalanine + 2 H2O

Equation

2 C16731 + C00027 <=> C16729 + C16734 + 2 C00001

Comment

thyroid peroxidase, TPO
following after R08521

RPair

RP00130	C00001_C00027 cofac
RP12723	C16729_C16731 main
RP12724	C16731_C16734 main
RP12725	C16729_C16731 trans

Enzyme

1.11.1.8

All links

Ontology (1)   
   KEGG BRITE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (10)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RPAIR (4)   
   KEGG RCLASS (2)   
All databases (16)   

Download RDF

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