KEGG   REACTION: R03102
Entry
R03102                      Reaction                               
Name
L-2-aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase
Definition
L-2-Aminoadipate 6-semialdehyde + NAD+ + H2O <=> L-2-Aminoadipate + NADH + H+
Equation
C04076 + C00003 + C00001 <=> C00956 + C00004 + C00080
Comment
NADP+ (see R03103)
two-step reaction (see R02317+R11231)
Reaction class
RC00001  C00003_C00004
RC00080  C00956_C04076
Enzyme
1.2.1.31
Pathway
rn00310  Lysine degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.31
     R03102  L-2-Aminoadipate 6-semialdehyde + NAD+ + H2O <=> L-2-Aminoadipate + NADH + H+
Orthology
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Other DBs
RHEA: 12311

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Ontology (1)   
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Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (900)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (899)   
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KEGG   REACTION: R03103
Entry
R03103                      Reaction                               
Name
L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase
Definition
L-2-Aminoadipate 6-semialdehyde + NADP+ + H2O <=> L-2-Aminoadipate + NADPH + H+
Equation
C04076 + C00006 + C00001 <=> C00956 + C00005 + C00080
Comment
NAD+ (see R03102)
two-step reaction (see R02317+R11232)
Reaction class
RC00001  C00005_C00006
RC00080  C00956_C04076
Enzyme
1.2.1.31
Pathway
rn00310  Lysine degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.31
     R03103  L-2-Aminoadipate 6-semialdehyde + NADP+ + H2O <=> L-2-Aminoadipate + NADPH + H+
Orthology
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Other DBs
RHEA: 12307

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (900)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (899)   
All databases (919)   

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KEGG   REACTION: R03098
Entry
R03098                      Reaction                               
Name
L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase;
ATP:L-2-aminoadipate 6-O-adenylyltransferase
Definition
L-2-Aminoadipate + ATP <=> L-2-Aminoadipate adenylate + Diphosphate
Equation
C00956 + C00002 <=> C05560 + C00013
Comment
The first step of three-step reaction (R03098+R04863+R04390)
For reverse direction, one-step reaction (see R03103)
Reaction class
RC00043  C00956_C05560
Enzyme
1.2.1.95
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.95
     R03098  L-2-Aminoadipate + ATP <=> L-2-Aminoadipate adenylate + Diphosphate
Orthology
K00143  L-2-aminoadipate reductase [EC:1.2.1.95]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (177)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (176)   
All databases (191)   

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KEGG   REACTION: R04390
Entry
R04390                      Reaction                               
Name
L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase
Definition
alpha-Aminoadipoyl-S-acyl enzyme + NADPH + H+ <=> L-2-Aminoadipate 6-semialdehyde + Holo-Lys2 + NADP+
Equation
C05535 + C00005 + C00080 <=> C04076 + C11482 + C00006
Comment
The last step of three step reaction  (R03098 + R04863 + R04390)
For reverse direction, one-step reaction (see R03103)
Reaction class
RC00001  C00005_C00006
RC00039  C05535_C11482
RC00184  C04076_C05535
Enzyme
1.2.1.95
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.95
     R04390  alpha-Aminoadipoyl-S-acyl enzyme + NADPH + H+ <=> L-2-Aminoadipate 6-semialdehyde + Holo-Lys2 + NADP+
Orthology
K00143  L-2-aminoadipate reductase [EC:1.2.1.95]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
Gene (177)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (176)   
All databases (195)   

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KEGG   REACTION: R04863
Entry
R04863                      Reaction                               
Name
L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase
Definition
L-2-Aminoadipate adenylate + Holo-Lys2 <=> alpha-Aminoadipoyl-S-acyl enzyme + AMP
Equation
C05560 + C11482 <=> C05535 + C00020
Comment
The second step of three-step reaction (R03098 + R04863 + R04390)
For reverse direction, one-step reaction (see R03103)
Reaction class
RC00039  C05535_C11482
RC00070  C00020_C05560
RC02816  C05535_C05560
Enzyme
1.2.1.95
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.95
     R04863  L-2-Aminoadipate adenylate + Holo-Lys2 <=> alpha-Aminoadipoyl-S-acyl enzyme + AMP
Orthology
K00143  L-2-aminoadipate reductase [EC:1.2.1.95]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
Gene (177)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (176)   
All databases (193)   

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