GenomeNet

Database: RefSeq
Entry: NC_000962
LinkDB: NC_000962
Original site: NC_000962 
LOCUS       NC_000962            4411532 bp    DNA     linear   CON 02-AUG-2016
DEFINITION  Mycobacterium tuberculosis H37Rv, complete genome.
ACCESSION   NC_000962
VERSION     NC_000962.3
DBLINK      BioProject: PRJNA57777
            Assembly: GCF_000195955.2
KEYWORDS    RefSeq; complete genome.
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Lew,J.M., Kapopoulou,A., Jones,L.M. and Cole,S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91 (1), 1-7 (2011)
   PUBMED   20980199
REFERENCE   2
  AUTHORS   Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148 (PT 10), 2967-2973 (2002)
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,
            Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,
            Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,
            Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,
            Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,
            Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,
            Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,
            Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and
            Barrell,B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393 (6685), 537-544 (1998)
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   4  (bases 1 to 4411532)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2013) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew,J.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-2012) Lew J., Ecole Polytechnique Federale de
            Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute
            of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4,
            SWITZERLAND
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence is identical to AL123456.
            On Feb 6, 2013 this sequence version replaced NC_000962.2.
            RefSeq Category: Reference Genome
                        FGS: First Genome sequenced
                        MOD: Model Organism
                        TYS: Designated Type Strain
                        UPR: UniProt Genome
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4411532
                     /organism="Mycobacterium tuberculosis H37Rv"
                     /mol_type="genomic DNA"
                     /strain="H37Rv"
                     /db_xref="taxon:83332"
     gene            1..1524
                     /gene="dnaA"
                     /locus_tag="Rv0001"
                     /experiment="DESCRIPTION:Mutation analysis, gene
                     expression[PMID: 10375628]"
                     /db_xref="GeneID:885041"
     CDS             1..1524
                     /gene="dnaA"
                     /locus_tag="Rv0001"
                     /experiment="DESCRIPTION:Mutation analysis, gene
                     expression[PMID: 10375628]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS01008"
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="NP_214515.1"
                     /db_xref="GeneID:885041"
                     /translation="MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQ
                     RAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAP
                     PATDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPHNTDS
                     ATAGVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLL
                     HAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFI
                     EGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPE
                     LETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDK
                     ALAEIVLRDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYL
                     CRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR"
     misc_feature    1..1512
                     /gene="dnaA"
                     /locus_tag="Rv0001"
                     /note="chromosomal replication initiation protein;
                     Provisional; Region: dnaA; cl28271"
                     /db_xref="CDD:333091"
     gene            2052..3260
                     /gene="dnaN"
                     /locus_tag="Rv0002"
                     /db_xref="GeneID:887092"
     CDS             2052..3260
                     /gene="dnaN"
                     /locus_tag="Rv0002"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="NP_214516.1"
                     /db_xref="GeneID:887092"
                     /translation="MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSG
                     VLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHV
                     EGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDT
                     LPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAG
                     IGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMD
                     VAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIA
                     FNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYV
                     YLLMPVRLPG"
     misc_feature    2094..3257
                     /gene="dnaN"
                     /locus_tag="Rv0002"
                     /note="DNA polymerase III subunit beta; Validated; Region:
                     PRK07761"
                     /db_xref="CDD:236089"
     misc_feature    order(2157..2159,2301..2303,2322..2324,2676..2678)
                     /gene="dnaN"
                     /locus_tag="Rv0002"
                     /note="putative DNA binding surface [nucleotide binding];
                     other site"
                     /db_xref="CDD:238082"
     misc_feature    order(2304..2306,2313..2315,2388..2390,2394..2396,
                     2916..2918,3006..3011)
                     /gene="dnaN"
                     /locus_tag="Rv0002"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238082"
     misc_feature    order(2592..2594,2598..2609,3057..3059,3237..3248)
                     /gene="dnaN"
                     /locus_tag="Rv0002"
                     /note="beta-clamp/clamp loader binding surface; other
                     site"
                     /db_xref="CDD:238082"
     misc_feature    order(2592..2594,2598..2603,2841..2843,2943..2945,
                     2982..2987,3066..3068,3237..3248)
                     /gene="dnaN"
                     /locus_tag="Rv0002"
                     /note="beta-clamp/translesion DNA polymerase binding
                     surface; other site"
                     /db_xref="CDD:238082"
     gene            3280..4437
                     /gene="recF"
                     /locus_tag="Rv0003"
                     /db_xref="GeneID:887089"
     CDS             3280..4437
                     /gene="recF"
                     /locus_tag="Rv0003"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00617"
                     /inference="protein motif:PROSITE:PS00618"
                     /note="single-stranded DNA-binding protein"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="NP_214517.1"
                     /db_xref="GeneID:887089"
                     /translation="MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALW
                     YSTTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSV
                     RSTRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVLRQ
                     RTALLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQL
                     LAPESRSASIGYRASMDVTGPSEQSDIDRQLLAARLLAALAARRDAELERGVCLVGPH
                     RDDLILRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVM
                     RRRALATAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP"
     misc_feature    3280..4419
                     /gene="recF"
                     /locus_tag="Rv0003"
                     /note="recF protein; Region: recf; TIGR00611"
                     /db_xref="CDD:273173"
     gene            4434..4997
                     /locus_tag="Rv0004"
                     /db_xref="GeneID:887088"
     CDS             4434..4997
                     /locus_tag="Rv0004"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214518.1"
                     /db_xref="GeneID:887088"
                     /translation="MTGSVDRPDQNRGERSMKSPGLDLVRRTLDEARAAARARGQDAG
                     RGRVASVASGRVAGRRRSWSGPGPDIRDPQPLGKAARELAKKRGWSVRVAEGMVLGQW
                     SAVVGHQIAEHARPTALNDGVLSVIAESTAWATQLRIMQAQLLAKIAAAVGNDVVRSL
                     KITGPAAPSWRKGPRHIAGRGPRDTYG"
     misc_feature    4437..4994
                     /locus_tag="Rv0004"
                     /note="hypothetical protein; Provisional; Region:
                     PRK03195"
                     /db_xref="CDD:179552"
     gene            5240..7267
                     /gene="gyrB"
                     /locus_tag="Rv0005"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:8031045]"
                     /db_xref="GeneID:887081"
     CDS             5240..7267
                     /gene="gyrB"
                     /locus_tag="Rv0005"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:8031045]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00177"
                     /note="Belongs to the type II topoisomerase family."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit B"
                     /protein_id="NP_214519.2"
                     /db_xref="GeneID:887081"
                     /translation="MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHH
                     LIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQ
                     LHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQ
                     GAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEV
                     VDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIV
                     DFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKD
                     RKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQL
                     THWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDP
                     RKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITA
                     LGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQP
                     PLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWET
                     TMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV"
     misc_feature    5252..7264
                     /gene="gyrB"
                     /locus_tag="Rv0005"
                     /note="DNA gyrase subunit B; Validated; Region: gyrB;
                     PRK05644"
                     /db_xref="CDD:235542"
     gene            7302..9818
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:8031045]"
                     /db_xref="GeneID:887105"
     CDS             7302..9818
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Mass spectrometry[PMID:21920479]"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:8031045]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /inference="protein motif:PROSITE:PS00018"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="NP_214520.1"
                     /db_xref="GeneID:887105"
                     /translation="MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEV
                     RDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQP
                     WSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRV
                     QEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAA
                     VMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPY
                     QVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKH
                     TQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILR
                     GLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQR
                     IIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDE
                     DLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDL
                     ILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLV
                     LATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIR
                     FSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEY
                     PVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQT
                     KGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN"
     misc_feature    7338..9764
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="DNA gyrase subunit A; Validated; Region: PRK05560"
                     /db_xref="CDD:235502"
     misc_feature    order(7410..7493,7506..7655,7659..7715,7719..7790,
                     7797..7799)
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="CAP-like domain; other site"
                     /db_xref="CDD:238111"
     misc_feature    7686..7688
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="active site"
                     /db_xref="CDD:238111"
     misc_feature    order(8496..8504,8511..8522,8553..8558,8598..8648)
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="primary dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238111"
     misc_feature    8844..8987
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="GyrA_CTD repeat [structural motif]; Region:
                     GyrA_CTD repeat"
                     /db_xref="CDD:293790"
     misc_feature    8994..9146
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="GyrA_CTD repeat [structural motif]; Region:
                     GyrA_CTD repeat"
                     /db_xref="CDD:293790"
     misc_feature    9162..9296
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="GyrA_CTD repeat [structural motif]; Region:
                     GyrA_CTD repeat"
                     /db_xref="CDD:293790"
     misc_feature    9306..9455
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="GyrA_CTD repeat [structural motif]; Region:
                     GyrA_CTD repeat"
                     /db_xref="CDD:293790"
     misc_feature    9462..9608
                     /gene="gyrA"
                     /locus_tag="Rv0006"
                     /note="GyrA_CTD repeat [structural motif]; Region:
                     GyrA_CTD repeat"
                     /db_xref="CDD:293790"
     gene            9914..10828
                     /locus_tag="Rv0007"
                     /db_xref="GeneID:885982"
     CDS             9914..10828
                     /locus_tag="Rv0007"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al.,2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214521.1"
                     /db_xref="GeneID:885982"
                     /translation="MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPP
                     PWQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADARLNRFISGASAPVTGPAAAVRT
                     PQPDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAG
                     SSGGRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMI
                     TVAFLYLVLGGMGVWAKLNSNVGDLLNNASGSSAELVSSGTIFGGAFLIGLVNIVLMT
                     ALATIGAFVYNLITDLIGGIEVTLADRD"
     misc_feature    <9950..10393
                     /locus_tag="Rv0007"
                     /note="DNA polymerase III subunits gamma and tau domain
                     III; Region: DNA_pol3_gamma3; cl26386"
                     /db_xref="CDD:331207"
     misc_feature    10469..10819
                     /locus_tag="Rv0007"
                     /note="Transmembrane domain of unknown function (DUF3566);
                     Region: DUF3566; pfam12089"
                     /db_xref="CDD:314895"
     gene            10887..10960
                     /gene="ileT"
                     /locus_tag="Rvnt01"
                     /db_xref="GeneID:2700464"
     tRNA            10887..10960
                     /gene="ileT"
                     /locus_tag="Rvnt01"
                     /product="tRNA-Ile"
                     /note="ileT, tRNA-Ile, anticodon gat, length = 74"
                     /anticodon=(pos:10921..10923,aa:Ile,seq:gat)
                     /codon_recognized="AUC"
                     /db_xref="GeneID:2700464"
     gene            11112..11184
                     /gene="alaT"
                     /locus_tag="Rvnt02"
                     /db_xref="GeneID:2700469"
     tRNA            11112..11184
                     /gene="alaT"
                     /locus_tag="Rvnt02"
                     /product="tRNA-Ala"
                     /note="alaT, tRNA-Ala, anticodon tgc, length = 73"
                     /anticodon=(pos:11145..11147,aa:Ala,seq:tgc)
                     /codon_recognized="GCA"
                     /db_xref="GeneID:2700469"
     gene            complement(11874..12311)
                     /locus_tag="Rv0008c"
                     /db_xref="GeneID:887085"
     CDS             complement(11874..12311)
                     /locus_tag="Rv0008c"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:23002219]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall synthesis protein CwsA"
                     /protein_id="NP_214522.1"
                     /db_xref="GeneID:887085"
                     /translation="MSEQVETRLTPRERLTRGLAYSAVGPVDVTRGLLELGVGLGLQS
                     ARSTAAGLRRRYREGRLAREVAAAQETLAQELTAAQDVVANLPQALQDARTQRRSKHH
                     LWIFAGIAAAILAGGAVAFSIVRRSSRPEPSPRPPSVEVQPRS"
     misc_feature    complement(11877..12287)
                     /locus_tag="Rv0008c"
                     /note="Cell wall synthesis protein CwsA; Region: CwsA;
                     pfam10814"
                     /db_xref="CDD:313910"
     gene            12468..13016
                     /gene="ppiA"
                     /locus_tag="Rv0009"
                     /gene_synonym="cfp22"
                     /db_xref="GeneID:887087"
     CDS             12468..13016
                     /gene="ppiA"
                     /locus_tag="Rv0009"
                     /gene_synonym="cfp22"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:15479239]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="alternate gene name: cfp22; belongs to the
                     cyclophilin-type PPIase family."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-regulated peptidyl-prolyl cis-trans
                     isomerase PpiA"
                     /protein_id="NP_214523.1"
                     /db_xref="GeneID:887087"
                     /translation="MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVG
                     LAQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFH
                     PELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAIS
                     KTATDGNDRPTDPVVIESITIS"
     misc_feature    12519..13001
                     /gene="ppiA"
                     /locus_tag="Rv0009"
                     /gene_synonym="cfp22"
                     /note="cyclophilin: cyclophilin-type peptidylprolyl cis-
                     trans isomerases. This family contains eukaryotic,
                     bacterial and archeal proteins which exhibit a
                     peptidylprolyl cis- trans isomerases activity (PPIase,
                     Rotamase) and in addition bind the...; Region:
                     cyclophilin; cd00317"
                     /db_xref="CDD:238194"
     misc_feature    order(12684..12686,12690..12692,12699..12704,12708..12710,
                     12813..12818,12843..12845,12849..12851,12873..12878,
                     12888..12890)
                     /gene="ppiA"
                     /locus_tag="Rv0009"
                     /gene_synonym="cfp22"
                     /note="active site"
                     /db_xref="CDD:238194"
     gene            complement(13133..13558)
                     /locus_tag="Rv0010c"
                     /db_xref="GeneID:887082"
     CDS             complement(13133..13558)
                     /locus_tag="Rv0010c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214524.1"
                     /db_xref="GeneID:887082"
                     /translation="MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAA
                     LGLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLL
                     EIETVSGGLLILSRWDLGTDPVEVLDALTAAGYAGRGQR"
     misc_feature    complement(13151..13387)
                     /locus_tag="Rv0010c"
                     /note="Bacterial PH domain; Region: bPH_6; pfam10756"
                     /db_xref="CDD:313871"
     gene            complement(13714..13995)
                     /locus_tag="Rv0011c"
                     /db_xref="GeneID:887074"
     CDS             complement(13714..13995)
                     /locus_tag="Rv0011c"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis, protein localization[PMID:21531798]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein CrgA"
                     /protein_id="NP_214525.1"
                     /db_xref="GeneID:887074"
                     /translation="MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIG
                     LIWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH"
     misc_feature    complement(13717..13995)
                     /locus_tag="Rv0011c"
                     /note="putative septation inhibitor protein; Reviewed;
                     Region: PRK00159"
                     /db_xref="CDD:178907"
     gene            14089..14877
                     /locus_tag="Rv0012"
                     /db_xref="GeneID:887083"
     CDS             14089..14877
                     /locus_tag="Rv0012"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214526.1"
                     /db_xref="GeneID:887083"
                     /translation="MRLTHPTPCPENGETMIDRRRSAWRFSVPLVCLLAGLLLAATHG
                     VSGGTEIRRSDAPRLVDLVRRAQASVNRLATEREALTTRIDSVHGRSVDTALAAMQRR
                     SAKLAGVAAMNPVHGPGLVVTLQDAQRDANGRFPRDASPDDLVVHQQDIEAVLNALWN
                     AGAEAIQMQDQRIIAMSIARCVGNTLLLNGRTYSPPYTIAAIGDAAAMQAALAAAPLV
                     TLYKQYVVRFGLGYCEEVHPDLQIVGYADPVRMHFAQPAGPLDY"
     misc_feature    14098..14865
                     /locus_tag="Rv0012"
                     /note="Uncharacterized conserved protein YlxW, UPF0749
                     family [Function unknown]; Region: YlxW; COG3879"
                     /db_xref="CDD:226396"
     gene            14914..15612
                     /gene="trpG"
                     /locus_tag="Rv0013"
                     /gene_synonym="pabA"
                     /db_xref="GeneID:885955"
     CDS             14914..15612
                     /gene="trpG"
                     /locus_tag="Rv0013"
                     /gene_synonym="pabA"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00442"
                     /inference="protein motif:PROSITE:PS00606"
                     /note="glutamine amidotransferase; note that previously
                     known as pabA."
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate synthase component II"
                     /protein_id="YP_177615.1"
                     /db_xref="GeneID:885955"
                     /translation="MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVA
                     GQFDGVLLSPGPGTPERAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPE
                     LLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQ
                     HTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPT
                     STASAGEATGRTSA"
     misc_feature    14914..15555
                     /gene="trpG"
                     /locus_tag="Rv0013"
                     /gene_synonym="pabA"
                     /note="para-aminobenzoate synthase component II;
                     Provisional; Region: PRK07765"
                     /db_xref="CDD:181107"
     misc_feature    order(15073..15078,15082..15084,15160..15165,15172..15174,
                     15304..15315)
                     /gene="trpG"
                     /locus_tag="Rv0013"
                     /gene_synonym="pabA"
                     /note="glutamine binding [chemical binding]; other site"
                     /db_xref="CDD:153214"
     misc_feature    order(15160..15162,15427..15429,15433..15435)
                     /gene="trpG"
                     /locus_tag="Rv0013"
                     /gene_synonym="pabA"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:153214"
     gene            complement(15590..17470)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /db_xref="GeneID:887072"
     CDS             complement(15590..17470)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis, protein purification and
                     characterization[PMID:21423706]"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:10531215]"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:21829358]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00107"
                     /inference="protein motif:PROSITE:PS00108"
                     /note="Belongs to the Ser/Thr family of protein kinases.
                     Experimental studies show evidence of auto-phosphorylation
                     on serine/threonine residues. PknB has been shown to be a
                     substrate for PstP and its kinase activity is affected by
                     PstP-mediated dephosphorylation. PknB and PstP (Rv0018c)
                     may act as a functional pair in vivo to control
                     mycobacterial cell growth."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine-protein kinase PknB"
                     /protein_id="NP_214528.1"
                     /db_xref="GeneID:887072"
                     /translation="MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRA
                     DLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD
                     IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIA
                     RAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG
                     DSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRV
                     HNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVA
                     VVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDS
                     TIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFG
                     RFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVA
                     QKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDL
                     SGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRF
                     GQ"
     misc_feature    complement(16652..17443)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="Catalytic domain of bacterial Serine/Threonine
                     kinases, PknB and similar proteins; Region:
                     STKc_PknB_like; cd14014"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(17192..17194,17240..17251,17264..17266,
                     17279..17281,17366..17371,17441..17443))
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(16928..16939,16994..16996,17003..17008,
                     17036..17038,17042..17047,17051..17053,17057..17059,
                     17168..17170,17174..17176,17186..17197,17255..17257,
                     17351..17353,17357..17359,17396..17398,17402..17413,
                     17417..17422))
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="active site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(17003..17008,17036..17038,17042..17047,
                     17051..17053,17174..17176,17186..17197,17255..17257,
                     17351..17353,17357..17359,17396..17398,17402..17413,
                     17417..17422))
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(16928..16939,16994..16996,17045..17047,
                     17051..17053,17057..17059,17168..17170,17174..17176,
                     17408..17410))
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(16928..16951,16982..17008))
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(15593..16396)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="PASTA domain, binds beta-lactams [Cell
                     wall/membrane/envelope biogenesis]; Region: PASTA;
                     COG2815"
                     /db_xref="CDD:225372"
     misc_feature    complement(16211..16390)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="PASTA domain [structural motif]; Region: PASTA
                     domain"
                     /db_xref="CDD:275384"
     misc_feature    complement(16007..16189)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="PASTA domain [structural motif]; Region: PASTA
                     domain"
                     /db_xref="CDD:275384"
     misc_feature    complement(15806..15985)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="PASTA domain [structural motif]; Region: PASTA
                     domain"
                     /db_xref="CDD:275384"
     misc_feature    complement(15599..15784)
                     /gene="pknB"
                     /locus_tag="Rv0014c"
                     /note="PASTA domain [structural motif]; Region: PASTA
                     domain"
                     /db_xref="CDD:275384"
     gene            complement(17467..18762)
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /db_xref="GeneID:885953"
     CDS             complement(17467..18762)
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis, protein purification and
                     characterization[PMID:21423706]"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:11856348]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00108"
                     /note="Belongs to the Ser/Thr family of protein kinases.
                     It has been shown that sodium orthovanadate inhibits the
                     activity of the enzyme in vitro."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine-protein kinase PknA"
                     /protein_id="NP_214529.1"
                     /db_xref="GeneID:885953"
                     /translation="MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVL
                     KSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEP
                     LNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDF
                     GIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFA
                     GDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRA
                     GRRPPRPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFS
                     SGQRALLWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDA
                     SPRLNWTERGETRHSGLQSWVVPPTPHSRASLARYEIAQ"
     misc_feature    complement(17944..18729)
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /note="Catalytic domain of bacterial Serine/Threonine
                     kinases, PknB and similar proteins; Region:
                     STKc_PknB_like; cd14014"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(18475..18477,18526..18537,18550..18552,
                     18565..18567,18652..18657,18727..18729))
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(18217..18228,18277..18279,18286..18291,
                     18319..18321,18325..18330,18334..18336,18340..18342,
                     18451..18453,18457..18459,18469..18480,18541..18543,
                     18637..18639,18643..18645,18682..18684,18688..18699,
                     18703..18708))
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /note="active site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(18286..18291,18319..18321,18325..18330,
                     18334..18336,18457..18459,18469..18480,18541..18543,
                     18637..18639,18643..18645,18682..18684,18688..18699,
                     18703..18708))
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(18217..18228,18277..18279,18328..18330,
                     18334..18336,18340..18342,18451..18453,18457..18459,
                     18694..18696))
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(18217..18240,18265..18291))
                     /gene="pknA"
                     /locus_tag="Rv0015c"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270916"
     gene            complement(18759..20234)
                     /gene="pbpA"
                     /locus_tag="Rv0016c"
                     /db_xref="GeneID:887078"
     CDS             complement(18759..20234)
                     /gene="pbpA"
                     /locus_tag="Rv0016c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:16436437]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PbpA"
                     /protein_id="NP_214530.1"
                     /db_xref="GeneID:887078"
                     /translation="MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVL
                     LDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALER
                     AEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKG
                     AVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETY
                     PPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLRE
                     AFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGM
                     TSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVS
                     PQVAAKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQ
                     APKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQGEP"
     misc_feature    complement(18765..>20102)
                     /gene="pbpA"
                     /locus_tag="Rv0016c"
                     /note="Cell division protein FtsI/penicillin-binding
                     protein 2 [Cell cycle control, cell division, chromosome
                     partitioning, Cell wall/membrane/envelope biogenesis];
                     Region: FtsI; COG0768"
                     /db_xref="CDD:223839"
     gene            complement(20231..21640)
                     /gene="rodA"
                     /locus_tag="Rv0017c"
                     /gene_synonym="ftsW"
                     /db_xref="GeneID:887075"
     CDS             complement(20231..21640)
                     /gene="rodA"
                     /locus_tag="Rv0017c"
                     /gene_synonym="ftsW"
                     /note="Belongs to the FTSW/RODA/SPOVE family."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein RodA"
                     /protein_id="NP_214531.1"
                     /db_xref="GeneID:887075"
                     /translation="MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQ
                     DQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLV
                     DNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPA
                     LLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGM
                     TLPRPRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTL
                     FAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQP
                     DTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLS
                     STLAIQLFIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRT
                     RPRNKSPITAAGTEVIERV"
     misc_feature    complement(20288..21430)
                     /gene="rodA"
                     /locus_tag="Rv0017c"
                     /gene_synonym="ftsW"
                     /note="Bacterial cell division protein FtsW, lipid II
                     flippase [Cell cycle control, cell division, chromosome
                     partitioning]; Region: FtsW; COG0772"
                     /db_xref="CDD:223843"
     gene            complement(21637..23181)
                     /gene="pstP"
                     /locus_tag="Rv0018c"
                     /db_xref="GeneID:887070"
     CDS             complement(21637..23181)
                     /gene="pstP"
                     /locus_tag="Rv0018c"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis, protein purification and
                     characterization[PMID:21423706]"
                     /experiment="DESCRIPTION:Mutation analysis, gene
                     expression, protein purification and
                     characterization[PMID:12950916]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Experimental studies have shown that PstP
                     specifically dephosporylates model phospho-Ser/Thr
                     substrates and it is likely that PknB (Rv0014c) and PstP
                     may act as a functional pair in vivo to control
                     mycobacterial cell growth."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoserine/threonine phosphatase PstP"
                     /protein_id="NP_214532.1"
                     /db_xref="GeneID:887070"
                     /translation="MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHA
                     AGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLT
                     AILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRS
                     LIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRL
                     IELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQ
                     RKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAG
                     SVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPE
                     RAQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVT
                     SSPASPSPTTSAPAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGI
                     DCRAAA"
     misc_feature    complement(22498..23169)
                     /gene="pstP"
                     /locus_tag="Rv0018c"
                     /note="Serine/threonine protein phosphatase PrpC [Signal
                     transduction mechanisms]; Region: PTC1; COG0631"
                     /db_xref="CDD:223704"
     misc_feature    complement(order(22609..22611,23062..23070,23107..23112,
                     23122..23124))
                     /gene="pstP"
                     /locus_tag="Rv0018c"
                     /note="active site"
                     /db_xref="CDD:238083"
     misc_feature    complement(<21691..>21909)
                     /gene="pstP"
                     /locus_tag="Rv0018c"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; cl25496"
                     /db_xref="CDD:330317"
     repeat_region   complement(23173..23273)
                     /note="101 bp Mycobacterial Interspersed Repetitive
                     Unit,Class I. See Supply et al. (1997) Molecular
                     Microbiology 26, 991-1003"
     gene            complement(23270..23737)
                     /gene="fhaB"
                     /locus_tag="Rv0019c"
                     /db_xref="GeneID:887079"
     CDS             complement(23270..23737)
                     /gene="fhaB"
                     /locus_tag="Rv0019c"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis, protein localization[PMID:20066037]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="FtsZ-interacting protein A"
                     /codon_start=1
                     /transl_table=11
                     /product="FHA domain-containing protein FhaB"
                     /protein_id="NP_214533.1"
                     /db_xref="GeneID:887079"
                     /translation="MQGLVLQLTRAGFLMLLWVFIWSVLRILKTDIYAPTGAVMMRRG
                     LALRGTLLGARQRRHAARYLVVTEGALTGARITLSEQPVLIGRADDSTLVLTDDYAST
                     RHARLSMRGSEWYVEDLGSTNGTYLDRAKVTTAVRVPIGTPVRIGKTAIELRP"
     misc_feature    complement(23282..23737)
                     /gene="fhaB"
                     /locus_tag="Rv0019c"
                     /note="Forkhead associated (FHA) domain, binds pSer, pThr,
                     pTyr [Signal transduction mechanisms]; Region: FHA;
                     COG1716"
                     /db_xref="CDD:224630"
     misc_feature    complement(order(23366..23374,23432..23437,23441..23443,
                     23477..23479))
                     /gene="fhaB"
                     /locus_tag="Rv0019c"
                     /note="phosphopeptide binding site; other site"
                     /db_xref="CDD:238017"
     gene            complement(23861..25444)
                     /gene="fhaA"
                     /locus_tag="Rv0020c"
                     /gene_synonym="TB39.8"
                     /db_xref="GeneID:887067"
     CDS             complement(23861..25444)
                     /gene="fhaA"
                     /locus_tag="Rv0020c"
                     /gene_synonym="TB39.8"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="FHA domain-containing protein FhaA"
                     /protein_id="NP_214534.1"
                     /db_xref="GeneID:887067"
                     /translation="MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREA
                     ADGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGWQTYG
                     DVVVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNS
                     SYRGGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRP
                     RHPDQGDYPEQIGYPDQGGYPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYE
                     QRPPVSPGPAAGYGAPGYDQGYRQSGGYGPSPGGGQPGYGGYGEYGRGPARHEEGSYV
                     PSGPPGPPEQRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYTRYTESPRVPGYAPQG
                     GGYAEPAGRDYDYGQSGAPDYGQPAPGGYSGYGQGGYGSAGTSVTLQLDDGSGRTYQL
                     REGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQ
                     LADGDVIRLGHSEIIVRMH"
     misc_feature    complement(25082..25423)
                     /gene="fhaA"
                     /locus_tag="Rv0020c"
                     /gene_synonym="TB39.8"
                     /note="Protein of unknown function (DUF2662); Region:
                     DUF3662; pfam12401"
                     /db_xref="CDD:315139"
     misc_feature    complement(<24314..24913)
                     /gene="fhaA"
                     /locus_tag="Rv0020c"
                     /gene_synonym="TB39.8"
                     /note="chromosomal replication initiation protein;
                     Provisional; Region: dnaA; cl28271"
                     /db_xref="CDD:333091"
     misc_feature    complement(23870..24124)
                     /gene="fhaA"
                     /locus_tag="Rv0020c"
                     /gene_synonym="TB39.8"
                     /note="Forkhead associated domain (FHA); found in
                     eukaryotic and prokaryotic proteins. Putative nuclear
                     signalling domain. FHA domains may bind phosphothreonine,
                     phosphoserine and sometimes phosphotyrosine. In
                     eukaryotes, many FHA domain-containing proteins...;
                     Region: FHA; cd00060"
                     /db_xref="CDD:238017"
     misc_feature    complement(order(23957..23965,24023..24028,24032..24034,
                     24068..24070))
                     /gene="fhaA"
                     /locus_tag="Rv0020c"
                     /gene_synonym="TB39.8"
                     /note="phosphopeptide binding site; other site"
                     /db_xref="CDD:238017"
     gene            25644..25726
                     /gene="leuT"
                     /locus_tag="Rvnt03"
                     /db_xref="GeneID:2700444"
     tRNA            25644..25726
                     /gene="leuT"
                     /locus_tag="Rvnt03"
                     /product="tRNA-Leu"
                     /note="leuT, tRNA-Leu, anticodon cag, length = 83"
                     /anticodon=(pos:25677..25679,aa:Leu,seq:cag)
                     /codon_recognized="CUG"
                     /db_xref="GeneID:2700444"
     gene            complement(25913..26881)
                     /locus_tag="Rv0021c"
                     /db_xref="GeneID:887066"
     CDS             complement(25913..26881)
                     /locus_tag="Rv0021c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214535.1"
                     /db_xref="GeneID:887066"
                     /translation="MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIG
                     GGYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVF
                     ADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVD
                     LVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLA
                     ATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAV
                     AARDYSIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV"
     misc_feature    complement(25916..26881)
                     /locus_tag="Rv0021c"
                     /note="NAD(P)H-dependent flavin oxidoreductase YrpB,
                     nitropropane dioxygenase family [General function
                     prediction only]; Region: YrpB; COG2070"
                     /db_xref="CDD:224981"
     gene            complement(27023..27442)
                     /gene="whiB5"
                     /locus_tag="Rv0022c"
                     /gene_synonym="whmG"
                     /db_xref="GeneID:887071"
     CDS             complement(27023..27442)
                     /gene="whiB5"
                     /locus_tag="Rv0022c"
                     /gene_synonym="whmG"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis[PMID:22733573]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="alternate gene name: whmG, WhiB-like regulatory
                     protein."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator WhiB5"
                     /protein_id="NP_214536.1"
                     /db_xref="GeneID:887071"
                     /translation="MAHPCATDPELWFGYPDDDGSDGAAKARAYERSATQARIQCLRR
                     CPLLQQRRCAQHAVEHRVEYGVWAGIKLPGGQYRKREQLAAAHDVLRRIAGGEINSRQ
                     LPDNAALLARNEGLEVTPVPGVVVHLPIAQVGPQPAA"
     misc_feature    complement(27197..27409)
                     /gene="whiB5"
                     /locus_tag="Rv0022c"
                     /gene_synonym="whmG"
                     /note="Transcription factor WhiB; Region: Whib; pfam02467"
                     /db_xref="CDD:308210"
     gene            27595..28365
                     /locus_tag="Rv0023"
                     /db_xref="GeneID:887062"
     CDS             27595..28365
                     /locus_tag="Rv0023"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214537.1"
                     /db_xref="GeneID:887062"
                     /translation="MSRESAGAAIRALRESRDWSLADLAAATGVSTMGLSYLERGARK
                     PHKSTVQKVENGLGLPPGTYSRLLVAADPDAELARLIAAQPSNPTAVRRAGAVVVDRH
                     SDTDVLEGYAEAQLDAIKSVIDRLPATTSNEYETYILSVIAQCVKAEMLAASSWRVAV
                     NAGADSTGRLMEHLRALEATRGALLERMPTSLSARFDRACAQSSLPEAVVAALIGVGA
                     DEMWDIRNRGVIPAGALPRVRAFVDAIEASHDADEGQQ"
     misc_feature    27613..27777
                     /locus_tag="Rv0023"
                     /note="Helix-turn-helix XRE-family like proteins.
                     Prokaryotic DNA binding proteins belonging to the
                     xenobiotic response element family of transcriptional
                     regulators; Region: HTH_XRE; cd00093"
                     /db_xref="CDD:238045"
     misc_feature    order(27625..27627,27637..27639,27712..27714)
                     /locus_tag="Rv0023"
                     /note="non-specific DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:238045"
     misc_feature    order(27634..27636,27709..27711)
                     /locus_tag="Rv0023"
                     /note="salt bridge; other site"
                     /db_xref="CDD:238045"
     misc_feature    order(27655..27660,27691..27693,27700..27702,27712..27717)
                     /locus_tag="Rv0023"
                     /note="sequence-specific DNA binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:238045"
     gene            28362..29207
                     /locus_tag="Rv0024"
                     /db_xref="GeneID:887061"
     CDS             28362..29207
                     /locus_tag="Rv0024"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="NLP/P60 family protein"
                     /protein_id="NP_214538.1"
                     /db_xref="GeneID:887061"
                     /translation="MNYSEVELLSRAHQLFAGDSRRPGLDAGTTPYGDLLSRAADLNV
                     GAGQRRYQLAVDHSRAALLSAARTDAAAGAVITGAQRDRAWARRSTGTVLDEARSDTT
                     VTAVMPIAQREAIRRRVARLRAQRAHVLTARRRARRHLAALRALRYRVAHGPGVALAK
                     LRLPSPSGRAGIAVHAALSRLGRPYVWGATGPNQFDCSGLVQWAYAQAGVHLDRTTYQ
                     QINEGIPVPRSQVRPGDLVFPHPGHVQLAIGNNLVVEAPHAGASVRVSSLGNNVQIRR
                     PLSGR"
     misc_feature    28905..29189
                     /locus_tag="Rv0024"
                     /note="NlpC/P60 family; Region: NLPC_P60; pfam00877"
                     /db_xref="CDD:307155"
     gene            29245..29607
                     /locus_tag="Rv0025"
                     /db_xref="GeneID:887060"
     CDS             29245..29607
                     /locus_tag="Rv0025"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214539.1"
                     /db_xref="GeneID:887060"
                     /translation="MSEQAGSSVAVIQERQALLARQHDAVAEADRELADVLASAHAAM
                     RESVRRLDAIAAELDRAVPDQDQLAVDTPMGAREFQTFLVAKQREIVAVVAAAHELDR
                     AKSAVLKRLRAQYTEPAR"
     misc_feature    29257..29589
                     /locus_tag="Rv0025"
                     /note="Domain of unknown function (DUF4226); Region:
                     DUF4226; pfam10774"
                     /db_xref="CDD:287715"
     gene            29722..31068
                     /locus_tag="Rv0026"
                     /db_xref="GeneID:887057"
     CDS             29722..31068
                     /locus_tag="Rv0026"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214540.1"
                     /db_xref="GeneID:887057"
                     /translation="MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVT
                     STTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDL
                     QVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIR
                     EVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPEL
                     PTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGAT
                     PALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDR
                     EGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQG
                     IAIPLPGTAVANPVDPARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF"
     misc_feature    29995..30273
                     /locus_tag="Rv0026"
                     /note="Domain of unknown function (DUF4226); Region:
                     DUF4226; pfam10774"
                     /db_xref="CDD:287715"
     gene            31189..31506
                     /locus_tag="Rv0027"
                     /db_xref="GeneID:887054"
     CDS             31189..31506
                     /locus_tag="Rv0027"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214541.1"
                     /db_xref="GeneID:887054"
                     /translation="MTDRIHVQPAHLRQAAAHHQQTADYLRTVPSSHDAIRESLDSLG
                     PIFSELRDTGRELLELRKQCYQQQADNHADIAQNLRTSAAMWEQHERAASRSLGNIID
                     GSR"
     misc_feature    31189..31485
                     /locus_tag="Rv0027"
                     /note="Excreted virulence factor EspC, type VII ESX
                     diderm; Region: T7SS_ESX_EspC; pfam10824"
                     /db_xref="CDD:313917"
     gene            31514..31819
                     /locus_tag="Rv0028"
                     /db_xref="GeneID:885812"
     CDS             31514..31819
                     /locus_tag="Rv0028"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214542.1"
                     /db_xref="GeneID:885812"
                     /translation="MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETL
                     AEAILLTADVSCLKALLEVRNEIVAAGHTPSAQVPTTDDLNVAIEKLLAHQLRRRNR"
     misc_feature    31514..31804
                     /locus_tag="Rv0028"
                     /note="Protein of unknown function (DUF2694); Region:
                     DUF2694; pfam10904"
                     /db_xref="CDD:287827"
     gene            32057..33154
                     /locus_tag="Rv0029"
                     /db_xref="GeneID:887053"
     CDS             32057..33154
                     /locus_tag="Rv0029"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214543.1"
                     /db_xref="GeneID:887053"
                     /translation="MAIFGRWSARQRLRRATRESLTIPTFSSSLDCTTRVIGGLWPAE
                     LSSNTAETATLAEHLKADLHRIVGSANDELMVIWRAGMADSTRRAEEDRVIDRARASA
                     MRRVESAMRELRQITGRVPVEIPRMRGAGGSDLDTTRLMPAVTVVQPADQACTDWPVA
                     AAEDDEARLQRLLAFVARQEPRLNWAVGVHADGTTVLVTDVAHGWIPPGIALPEGVRL
                     LAPARRAGRAPELVGITTCCKTYTPGDSLRRAVDSTAPTSSVQPRALPAIAGLSVELG
                     IATQRHDGLPKIVHAMATAAGNGAAAEEVDLLRVHVDTALHHVLAQYPRVDPALLLNC
                     MLLAATERSVTGDPIAANYHFAWFRELDSRR"
     gene            33224..33553
                     /locus_tag="Rv0030"
                     /db_xref="GeneID:887051"
     CDS             33224..33553
                     /locus_tag="Rv0030"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214544.1"
                     /db_xref="GeneID:887051"
                     /translation="MVSGSDSRSEPSQLSDRDLVESVLRDLSEAADKWEALVTQAETV
                     TYSVDLGDVRAVANSDGRLLELTLHPGVMTGYAHGELADRVNLAITALRDEVEAENRA
                     RYGGRLQ"
     misc_feature    33230..33541
                     /locus_tag="Rv0030"
                     /note="Protein of unknown function (DUF2710); Region:
                     DUF2710; pfam10921"
                     /db_xref="CDD:287837"
     gene            34295..36610
                     /gene="bioF2"
                     /locus_tag="Rv0032"
                     /db_xref="GeneID:887050"
     CDS             34295..36610
                     /gene="bioF2"
                     /locus_tag="Rv0032"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00599"
                     /codon_start=1
                     /transl_table=11
                     /product="8-amino-7-oxononanoate synthase"
                     /protein_id="NP_214546.1"
                     /db_xref="GeneID:887050"
                     /translation="MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSV
                     CFDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPV
                     LAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVE
                     EALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQRE
                     DLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYR
                     KANLYRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHT
                     ATLARMMMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKL
                     GGVYGFYPRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
                     SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDAL
                     NHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLAT
                     IAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFI
                     AGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATG
                     LARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTS
                     YLADHRQSDLDRALHVFAGLAEDLTPQGAAL"
     misc_feature    34838..35215
                     /gene="bioF2"
                     /locus_tag="Rv0032"
                     /note="N-Acyltransferase superfamily: Various enyzmes that
                     characteristicly catalyze the transfer of an acyl group to
                     a substrate; Region: NAT_SF; cl17182"
                     /db_xref="CDD:327402"
     misc_feature    35444..36574
                     /gene="bioF2"
                     /locus_tag="Rv0032"
                     /note="7-keto-8-aminopelargonate synthetase or related
                     enzyme [Coenzyme transport and metabolism]; Region: BioF;
                     COG0156"
                     /db_xref="CDD:223234"
     gene            36607..36870
                     /gene="acpA"
                     /locus_tag="Rv0033"
                     /gene_synonym="acpP"
                     /db_xref="GeneID:887052"
     CDS             36607..36870
                     /gene="acpA"
                     /locus_tag="Rv0033"
                     /gene_synonym="acpP"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein AcpA"
                     /protein_id="NP_214547.1"
                     /db_xref="GeneID:887052"
                     /translation="MKEAINATIQRILRTDRGITANQVLVDDLGFDSLKLFQLITELE
                     DEFDIAISFRDAQNIKTVGDVYTSVAVWFPETAKPAPLGKGTA"
     misc_feature    36607..36813
                     /gene="acpA"
                     /locus_tag="Rv0033"
                     /gene_synonym="acpP"
                     /note="Acyl carrier protein [Lipid transport and
                     metabolism, Secondary metabolites biosynthesis, transport
                     and catabolism]; Region: AcpP; COG0236"
                     /db_xref="CDD:223314"
     gene            36867..37262
                     /locus_tag="Rv0034"
                     /db_xref="GeneID:887046"
     CDS             36867..37262
                     /locus_tag="Rv0034"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214548.1"
                     /db_xref="GeneID:887046"
                     /translation="MTDDADLDLVRRTFAAFARGDLAELTQCFAPDVEQFVPGKHALA
                     GVFRGVDNVVACLGDTAAAADGTMTVTLEDVLSNTDGQVIAVYRLRASRAGKVLDQRE
                     AILVTVAGGRITRLSEFYADPAATESFWA"
     misc_feature    36867..37259
                     /locus_tag="Rv0034"
                     /note="Ketosteroid isomerase-related protein [General
                     function prediction only]; Region: YesE; COG3631"
                     /db_xref="CDD:226158"
     gene            37259..38947
                     /gene="fadD34"
                     /locus_tag="Rv0035"
                     /db_xref="GeneID:887048"
     CDS             37259..38947
                     /gene="fadD34"
                     /locus_tag="Rv0035"
                     /codon_start=1
                     /transl_table=11
                     /product="fatty-acid--CoA ligase FadD34"
                     /protein_id="YP_177686.1"
                     /db_xref="GeneID:887048"
                     /translation="MTAALLSPAIAWQQISACTDRTLTITCEDSEVISYQDLIARAAA
                     CIPPLRRLDLKRGEPVLITAHTNLEFLSCFLGLMLHGAVPVPIPPREALKTTERFMTR
                     LGPLLRHHRVLICTPAEHDEIRAAASTDCQISRFTALAEAGDEQFGRATAQQLADTAT
                     ADWPLCTLDDDAYVQYTSGSTAAPRGVVITYRNLLSNMRAMAVGSQFQHGDVMGSWLP
                     LHHDMGLVGSLFAALFNSVSAVFTTPHRFLYDPLGFLRLLTSSGATHTFMPNFALEWL
                     INAYHRRGADIEGIDLHKMRRLIIASEPVHAEGMRRFAATFAGVGLAPTALGSGYGLA
                     EATVAVSMSAPNTGFRTETHAAAEVVTGGRVLPGYEVRIDAAPGARAGTIKLRGDSVA
                     AKAYVGGKKLDALDEEGFCDTHDLGFLVDDEIVILGRQDEVFIVHGENRFPYDIEFII
                     RGESEQHRTKVACFGVNERVVVVLESPLDSIIDKAEADRLRCQVVAATGLQLDELITV
                     RRGAIPTTTSGKLKRRAVAQAYRDGTLPRLATHAWTADPDSAPKTTRSSLEGAH"
     misc_feature    37295..38854
                     /gene="fadD34"
                     /locus_tag="Rv0035"
                     /note="Fatty acyl-AMP ligase (FAAL); Region: FAAL;
                     cd05931"
                     /db_xref="CDD:213297"
     misc_feature    order(37778..37780,37787..37804,37808..37813)
                     /gene="fadD34"
                     /locus_tag="Rv0035"
                     /note="acyl-activating enzyme (AAE) consensus motif; other
                     site"
                     /db_xref="CDD:213297"
     misc_feature    order(37859..37861,37919..37927,38153..38155,38162..38173,
                     38246..38260,38273..38275,38342..38344,38501..38503,
                     38534..38536,38543..38545)
                     /gene="fadD34"
                     /locus_tag="Rv0035"
                     /note="active site"
                     /db_xref="CDD:213297"
     gene            complement(39056..39829)
                     /locus_tag="Rv0036c"
                     /db_xref="GeneID:887043"
     CDS             complement(39056..39829)
                     /locus_tag="Rv0036c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214550.1"
                     /db_xref="GeneID:887043"
                     /translation="MADPGPFVADLRAESDDLDALVAHLPADRWADPTPAPGWTIAHQ
                     IGHLLWTDRVALTAVTDEAGFAELMTAAAANPAGFVDDAATELAAVSPAELLTDWRVT
                     RGRLHEELLAVPDGRKLAWFGPPMSAASMATARLMETWAHGLDVADALGVIRPATQRL
                     RSIAHLGVRTRDYAFIVNNLTPPAEPFLVELRGPSGDTWSWGPSDAAQRVTGSAEDFC
                     FLVTQRRALSTLDVNAVGEDAQRWLTIAQAFAGPPGRGR"
     misc_feature    complement(39059..39808)
                     /locus_tag="Rv0036c"
                     /note="TIGR03084 family protein; Region: TIGR03084"
                     /db_xref="CDD:274423"
     gene            complement(39877..41202)
                     /locus_tag="Rv0037c"
                     /db_xref="GeneID:887042"
     CDS             complement(39877..41202)
                     /locus_tag="Rv0037c"
                     /experiment="DESCRIPTION:Mass spectrometry[PMID:21920479]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /note="member of major facilitator superfamily (MFS)
                     possibly involved in transport of macrolide; integral
                     membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS-type transporter"
                     /protein_id="NP_214551.1"
                     /db_xref="GeneID:887042"
                     /translation="MPRVEVGLVIHSRMHARAPVDVWRSVRSLPDFWRLLQVRVASQF
                     GDGLFQAGLAGALLFNPDRAADPMAIAGAFAVLFLPYSLLGPFAGALMDRWDRRWVLV
                     GANTGRLALIAGVGTILAVGAGDVPLLVGALVANGLARFVASGLSAALPHVVPREQVV
                     TMNSVAIASGAVSAFLGANFMLLPRWLLGSGDEGASAIVFLVAIPVSIALLWSLRFGP
                     RVLGPDDTERAIHGSAVYAVVTGWLHGARTVVQLPTVAAGLSGLAAHRMVVGINSLLI
                     LLLVRHVTARAVGGLGTALLFFAATGLGAFLANVLTPTAIRRWGRYATANGALAAAAT
                     IQVAAAGLLVPVMVVCGFLLGVAGQVVKLCADSAMQMDVDDALRGHVFAVQDALFWVS
                     YILSITVAAALIPEHGHAPVFVLFGSAIYLAGLVVHTIVGRRGQPVIGR"
     misc_feature    complement(39988..41109)
                     /locus_tag="Rv0037c"
                     /note="Transmembrane secretion effector; Region: MFS_3;
                     cl27934"
                     /db_xref="CDD:332755"
     gene            41304..41912
                     /locus_tag="Rv0038"
                     /db_xref="GeneID:887045"
     CDS             41304..41912
                     /locus_tag="Rv0038"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214552.1"
                     /db_xref="GeneID:887045"
                     /translation="MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIV
                     EHNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRVGA
                     DPEGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWI
                     VLSALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN"
     misc_feature    41340..41900
                     /locus_tag="Rv0038"
                     /note="hypothetical protein; Validated; Region: PRK00228"
                     /db_xref="CDD:234694"
     gene            complement(42004..42351)
                     /locus_tag="Rv0039c"
                     /db_xref="GeneID:887038"
     CDS             complement(42004..42351)
                     /locus_tag="Rv0039c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214553.1"
                     /db_xref="GeneID:887038"
                     /translation="MFLAGVLCMCAAAASALFGSWSLCHTPTADPTALALRAMAPTQL
                     AAAVMLAAGGVVAVAAPGHTALMVVIVCIAGAVGTLAAGSWQSAQYALRRETASPTAN
                     CVGSCAVCTQACH"
     gene            complement(42433..43365)
                     /gene="mtc28"
                     /locus_tag="Rv0040c"
                     /db_xref="GeneID:887037"
     CDS             complement(42433..43365)
                     /gene="mtc28"
                     /locus_tag="Rv0040c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927); secreted antigen"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214554.2"
                     /db_xref="GeneID:887037"
                     /translation="MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAP
                     VSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAI
                     SGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNS
                     VYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTY
                     RENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAP
                     AQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR"
     misc_feature    complement(42556..43059)
                     /gene="mtc28"
                     /locus_tag="Rv0040c"
                     /note="Probable lipoprotein LpqN; Region: Lpp-LpqN;
                     pfam10738"
                     /db_xref="CDD:313855"
     gene            43562..46471
                     /gene="leuS"
                     /locus_tag="Rv0041"
                     /db_xref="GeneID:887040"
     CDS             43562..46471
                     /gene="leuS"
                     /locus_tag="Rv0041"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00178"
                     /note="leucyl-tRNA synthetase LeuS; Aminoacyl-transfer RNA
                     synthetases class-I signature. Belongs to class-I
                     aminoacyl-tRNA synthetase family."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="NP_214555.1"
                     /db_xref="GeneID:887040"
                     /translation="MTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWA
                     RLGTFNVPNPVGSLAPPDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARY
                     FRMVGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRR
                     SFSTTDVDFYRWTQWIFLQIYNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKL
                     TAGERADVIDEYRLVYRADSLVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQW
                     MMRITAYADRLLDDLDVLDWPEQVKTMQRNWIGRSTGAVALFSARAASDDGFEVDIEV
                     FTTRPDTLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRAIA
                     AKSDLERQESREKTGVFLGSYAINPANGEPVPIFIADYVLAGYGTGAIMAVPGHDQRD
                     WDFARAFGLPIVEVIAGGNISESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGR
                     GRARIEFKLRDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSPVLFD
                     PDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNS
                     ERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYSRFWHKVLYDLGHV
                     SSREPYRRLVNQGYIQAYAYTDARGSYVPAEQVIERGDRFVYPGPDGEVEVFQEFGKI
                     GKSLKNSVSPDEICDAYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVV
                     DEHTGETRVADGVELDIDTLRALHRTIVGVSEDFAALRNNTATAKLIEYTNHLTKKHR
                     DAVPRAAVEPLVQMLAPLAPHIAEELWLRLGNTTSLAHGPFPKADAAYLVDETVEYPV
                     QVNGKVRGRVVVAADTDEETLKAAVLTDEKVQAFLAGATPRKVIVVAGRLVNLVI"
     misc_feature    43637..46468
                     /gene="leuS"
                     /locus_tag="Rv0041"
                     /note="leucyl-tRNA synthetase; Validated; Region: leuS;
                     PRK00390"
                     /db_xref="CDD:234743"
     gene            complement(46581..47207)
                     /locus_tag="Rv0042c"
                     /db_xref="GeneID:887034"
     CDS             complement(46581..47207)
                     /locus_tag="Rv0042c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214556.1"
                     /db_xref="GeneID:887034"
                     /translation="MSVVRSIGKKMQRISGPNALAVKGRPTQVYGHTHVRLDCRFMAD
                     SEFTAPEVTQLAEGLHRALSKLISMLRRGDPNGAAAGDLTLAQLSILVTLLDQGPIRM
                     TDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRAVLVDITPQGRAVHGESLANR
                     RAALAALLSQLPRSDLETLRKALAPLERLASGEPASGPASNSPARKRA"
     misc_feature    complement(<46749..46964)
                     /locus_tag="Rv0042c"
                     /note="helix_turn_helix multiple antibiotic resistance
                     protein; Region: HTH_MARR; cl28354"
                     /db_xref="CDD:333174"
     gene            complement(47366..48100)
                     /locus_tag="Rv0043c"
                     /db_xref="GeneID:887032"
     CDS             complement(47366..48100)
                     /locus_tag="Rv0043c"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_214557.1"
                     /db_xref="GeneID:887032"
                     /translation="MPKKYGVKEKDQVVAHILNLLLTGKLRSGDRVDRNEIAHGLGVS
                     RVPIQEALVQLEHDGIVSTRYHRGAFIERFDVATILEHHELDGLLNGIASARAAANPT
                     PRILGQLDAVMRSLRNSKESRAFAECVWEYRRTVNDEYAGPRLHATIRASQNLIPRVF
                     WMTYQNSRDDVLPFYEEENAAIHRREPEAARAACIGRSELMAQTMLAELFRRRVLVPP
                     EGACPGPFGAPIPGFARSYQPSSPVP"
     misc_feature    complement(47426..48073)
                     /locus_tag="Rv0043c"
                     /note="DNA-binding transcriptional regulator, GntR family
                     [Transcription]; Region: GntR; COG1802"
                     /db_xref="CDD:224715"
     gene            complement(48233..49027)
                     /locus_tag="Rv0044c"
                     /db_xref="GeneID:887030"
     CDS             complement(48233..49027)
                     /locus_tag="Rv0044c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214558.1"
                     /db_xref="GeneID:887030"
                     /translation="MTSLVRPDLPVRIGVQLQPQHAPHYRAVRDAVRRCEDIGVDIAF
                     TWDHFFPLYGDPDGPHFECWTVLGAWAEQTSHIEIGALVTCNSYRNPELLADMARTVD
                     HISGGRLILGIGSGWKQKDYDEYGYRFGTAGSRLDDLAAALPRIKARLGKLNPPPTRD
                     IPVLIGGGGERKTLRLVAEYADIWHSFTAGDSYLAKSAVLSTHCSTVGRNPATIERSA
                     AVDGGGLIASAEALAGLGVTLLTVGCDGPDYDLSAAAALCRWRDGR"
     misc_feature    complement(48242..48997)
                     /locus_tag="Rv0044c"
                     /note="probable F420-dependent oxidoreductase, MSMEG_2906
                     family; Region: F420_MSMEG_2906; TIGR03856"
                     /db_xref="CDD:213873"
     gene            complement(49043..49939)
                     /locus_tag="Rv0045c"
                     /db_xref="GeneID:887029"
     CDS             complement(49043..49939)
                     /locus_tag="Rv0045c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="NP_214559.1"
                     /db_xref="GeneID:887029"
                     /translation="MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALR
                     WGGSAPRVIFLHGGGQNAHTWDTVIVGLGEPALAVDLPGHGHSAWREDGNYSPQLNSE
                     TLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDVTPSALQRHAELTA
                     EQRGTVALMHGEREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRYD
                     AIRTFGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRATHFRGVHIVEKSG
                     HSVQSDQPRALIEIVRGVLDTR"
     misc_feature    complement(49046..49825)
                     /locus_tag="Rv0045c"
                     /note="Pimeloyl-ACP methyl ester carboxylesterase
                     [Coenzyme transport and metabolism, General function
                     prediction only]; Region: MhpC; COG0596"
                     /db_xref="CDD:223669"
     gene            complement(50021..51124)
                     /gene="ino1"
                     /locus_tag="Rv0046c"
                     /gene_synonym="tbINO"
                     /db_xref="GeneID:887028"
     CDS             complement(50021..51124)
                     /gene="ino1"
                     /locus_tag="Rv0046c"
                     /gene_synonym="tbINO"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression[PMID:10448034]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Myo-inositol 1-phosphate synthase (MI-1-P synthase)
                     (MIP synthase)"
                     /codon_start=1
                     /transl_table=11
                     /product="inositol-3-phosphate synthase"
                     /protein_id="NP_214560.1"
                     /db_xref="GeneID:887028"
                     /translation="MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTS
                     TVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVI
                     VQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQC
                     AIDAGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDR
                     GVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDH
                     VGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIG
                     GPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG"
     misc_feature    complement(50030..51079)
                     /gene="ino1"
                     /locus_tag="Rv0046c"
                     /gene_synonym="tbINO"
                     /note="Myo-inositol-1-phosphate synthase; Region:
                     NAD_binding_5; cl00554"
                     /db_xref="CDD:321039"
     gene            complement(51185..51727)
                     /locus_tag="Rv0047c"
                     /db_xref="GeneID:887031"
     CDS             complement(51185..51727)
                     /locus_tag="Rv0047c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214561.1"
                     /db_xref="GeneID:887031"
                     /translation="MLELAILGLLIESPMHGYELRKRLTGLLGAFRAFSYGSLYPALR
                     RMQADGLIAENAAPAGTPVRRARRVYQLTDKGRRRFGELVADTGPHNYTDDGFGVHLA
                     FFNRTPAEARMRILEGRRRQVEERREGLREAVARASSSFDRYTRQLHQLGLESSEREV
                     KWLNELIAAERAAPNPAEQT"
     misc_feature    complement(51488..51712)
                     /locus_tag="Rv0047c"
                     /note="Transcriptional regulator PadR-like family; Region:
                     PadR; pfam03551"
                     /db_xref="CDD:308908"
     gene            complement(51828..52697)
                     /locus_tag="Rv0048c"
                     /db_xref="GeneID:887027"
     CDS             complement(51828..52697)
                     /locus_tag="Rv0048c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214562.1"
                     /db_xref="GeneID:887027"
                     /translation="MAKWLGAPLARGVSTATRAKDSDRQDACRILDDALRDGELSMEE
                     HRERVSAATKAVTLGDLQRLVADLQVESAPAQMPALKSRAKRTELGLLAAAFVASVLL
                     GVGIGWGVYGNTRSPLDFTSDPGAKPDGIAPVVLTPPRQLHSLGGLTGLLEQTRKRFG
                     DTMGYRLVIYPEYASLDRVDPADDRRVLAYTYRGGWGDATSSAKSIADVSVVDLSKFD
                     AKTAVGIMRGAPETLGLKQSDVKSMYLIVEPVKDPTTPAALSLSLYVSSDYGGGYLVF
                     AGDGTIKHVSYPS"
     misc_feature    complement(52494..52649)
                     /locus_tag="Rv0048c"
                     /note="Domain of unknown function (DUF1707); Region:
                     DUF1707; pfam08044"
                     /db_xref="CDD:311825"
     gene            52831..53244
                     /locus_tag="Rv0049"
                     /db_xref="GeneID:887024"
     CDS             52831..53244
                     /locus_tag="Rv0049"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214563.1"
                     /db_xref="GeneID:887024"
                     /translation="MDYTLRRRSLLAEVYSGRTGVSEVCDANPYLLRAAKFHGKPSRV
                     ICPICRKEQLTLVSWVFGEHLGAVSGSARTAEELILLATRFSEFAVHVVEVCRTCSWN
                     HLVKSYVLGAARPARPPRGSGGTRTARNGARTASE"
     gene            53663..55699
                     /gene="ponA1"
                     /locus_tag="Rv0050"
                     /db_xref="GeneID:887065"
     CDS             53663..55699
                     /gene="ponA1"
                     /locus_tag="Rv0050"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:11802794]"
                     /experiment="DESCRIPTION:Protein expression and
                     characterization[PMID:20686708]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="penicillin-binding protein 1A/1B;
                     penicillin-binding protein (class A), bienzymatic protein
                     with transglycosylase and transpeptidase activities"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional penicillin-insensitive
                     transglycosylase/penicillin-sensitive transpeptidase"
                     /protein_id="YP_177687.1"
                     /db_xref="GeneID:887065"
                     /translation="MVILLPMVTFTMAYLIVDVPKPGDIRTNQVSTILASDGSEIAKI
                     VPPEGNRVDVNLSQVPMHVRQAVIAAEDRNFYSNPGFSFTGFARAVKNNLFGGDLQGG
                     STITQQYVKNALVGSAQHGWSGLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRG
                     AYGISAASKAYFDKPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMV
                     ETKALSPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQTLNT
                     QGLVVTTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVRAYYGGDNANGF
                     DFAQAGLQTGSSFKVFALVAALEQGIGLGYQVDSSPLTVDGIKITNVEGEGCGTCNIA
                     EALKMSLNTSYYRLMLKLNGGPQAVADAAHQAGIASSFPGVAHTLSEDGKGGPPNNGI
                     VLGQYQTRVIDMASAYATLAASGIYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPK
                     AVADNVTAAMEPIAGYSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTA
                     VWVGTVKGDEPLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAGV
                     PPPPPPPEVPPSETVIQPTVEIAPGITIPIGPPTTITLAPPPPAPPAATPTPPP"
     misc_feature    53771..54316
                     /gene="ponA1"
                     /locus_tag="Rv0050"
                     /note="Transglycosylase; Region: Transgly; pfam00912"
                     /db_xref="CDD:279281"
     misc_feature    53810..55480
                     /gene="ponA1"
                     /locus_tag="Rv0050"
                     /note="penicillin-binding protein, 1A family; Region:
                     PBP_1a_fam; TIGR02074"
                     /db_xref="CDD:273955"
     misc_feature    54590..55465
                     /gene="ponA1"
                     /locus_tag="Rv0050"
                     /note="Penicillin binding protein transpeptidase domain;
                     Region: Transpeptidase; pfam00905"
                     /db_xref="CDD:279276"
     gene            55696..57378
                     /locus_tag="Rv0051"
                     /db_xref="GeneID:887018"
     CDS             55696..57378
                     /locus_tag="Rv0051"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214565.1"
                     /db_xref="GeneID:887018"
                     /translation="MTGALSQSSNISPLPLAADLRSADNRDCPSRTDVLGAALANVVG
                     GPVGRHALIGRTRLMTPLRVMFAIALVFLALGWSTKAACLQSTGTGPGDQRVANWDNQ
                     RAYYQLCYSDTVPLYGAELLSQGKFPYKSSWIETDSNGTPQLRYDGQIAVRYMEYPVL
                     TGIYQYLSMAIAKTYTALSKVAPLPVVAEVVMFFNVAAFGLALAWLTTVWATSGLAGR
                     RIWDAALVAASPLVIFQIFTNFDALATGLATSGLLAWARRRPVLAGVLIGLGSAAKLY
                     PLLFLYPLLLLGIRAGRLNALARTMAAAAATWLLVNLPVMLLFPRGWSEFFRLNTRRG
                     DDMDSLYNVVKSFTGWRGFDPTLGFWEPPLVLNTVVTLLFVLCCAAIAYIALTAPHRP
                     RVAQLTFLTVASFLLVNKVWSPQFSLWLVPLAVLALPHRRILLAWMTIDALVWVPRMY
                     YLYGNPSRSLPEQWFTTTVLLRDIAVMVLCGLVVWQIYRPGRDLVRTGGPGALPACGG
                     VDDPVGGVFANAADAPPGRLPSWLRPRLGDEHARERTPDAGRDRTFSGQHRA"
     misc_feature    55753..57375
                     /locus_tag="Rv0051"
                     /note="Uncharacterized membrane protein [Function
                     unknown]; Region: COG5650"
                     /db_xref="CDD:227937"
     gene            57410..57973
                     /locus_tag="Rv0052"
                     /db_xref="GeneID:887015"
     CDS             57410..57973
                     /locus_tag="Rv0052"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214566.3"
                     /db_xref="GeneID:887015"
                     /translation="MPSFDVVFVGHRRGEVRSDNAMLGLLCDAAFDELTRPDVVIFPG
                     GIGTRTLIHDQTVLDWVREAHRHTLLTTSVCTGGLVLAAAGLLNGLTATTHWRVQDLF
                     NSLGARYVPQRVVEHLPERVITAAGVSSGIDMGLRLVELLVSREAAEASQLMIEYDPQ
                     PPVDAGSLAKASPATHRLALEFYQHRL"
     misc_feature    57413..57883
                     /locus_tag="Rv0052"
                     /note="Type 1 glutamine amidotransferase (GATase1)-like
                     domain found in a subgroup of proteins similar to PfpI
                     from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139"
                     /db_xref="CDD:153233"
     misc_feature    57632..57634
                     /locus_tag="Rv0052"
                     /note="conserved cys residue [active]"
                     /db_xref="CDD:153233"
     gene            58192..58482
                     /gene="rpsF"
                     /locus_tag="Rv0053"
                     /db_xref="GeneID:887020"
     CDS             58192..58482
                     /gene="rpsF"
                     /locus_tag="Rv0053"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS01048"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="NP_214567.1"
                     /db_xref="GeneID:887020"
                     /translation="MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWG
                     KRRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH"
     misc_feature    58192..58479
                     /gene="rpsF"
                     /locus_tag="Rv0053"
                     /note="30S ribosomal protein S6; Reviewed; Region: rpsF;
                     PRK00453"
                     /db_xref="CDD:179034"
     misc_feature    order(58201..58203,58339..58341,58351..58353,58396..58398,
                     58405..58410,58429..58431,58450..58452,58459..58467)
                     /gene="rpsF"
                     /locus_tag="Rv0053"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275385"
     misc_feature    order(58204..58206,58210..58212,58327..58329,58333..58341,
                     58369..58371,58375..58377,58450..58452,58462..58464)
                     /gene="rpsF"
                     /locus_tag="Rv0053"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275385"
     gene            58586..59080
                     /gene="ssb"
                     /locus_tag="Rv0054"
                     /db_xref="GeneID:887013"
     CDS             58586..59080
                     /gene="ssb"
                     /locus_tag="Rv0054"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:10491108]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="single-strand DNA-binding protein"
                     /protein_id="NP_214568.1"
                     /db_xref="GeneID:887013"
                     /translation="MAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQT
                     GEWKDGEALFLRCNIWREAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVE
                     VDEIGPSLRYATAKVNKASRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDD
                     EPPF"
     misc_feature    58586..59077
                     /gene="ssb"
                     /locus_tag="Rv0054"
                     /note="single-stranded DNA-binding protein; Provisional;
                     Region: PRK07772"
                     /db_xref="CDD:236092"
     misc_feature    order(58604..58615,58688..58696,58742..58744,58748..58750,
                     58811..58813,58838..58840,58871..58873,58880..58882)
                     /gene="ssb"
                     /locus_tag="Rv0054"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239942"
     misc_feature    order(58619..58627,58643..58645,58673..58675,58694..58699,
                     58736..58741,58745..58747,58751..58753,58757..58759,
                     58763..58765,58802..58807,58829..58831,58835..58837,
                     58841..58846,58883..58885,58889..58891)
                     /gene="ssb"
                     /locus_tag="Rv0054"
                     /note="ssDNA binding site [nucleotide binding]; other
                     site"
                     /db_xref="CDD:239942"
     misc_feature    order(58811..58813,58817..58819,58823..58825,58904..58906)
                     /gene="ssb"
                     /locus_tag="Rv0054"
                     /note="tetramer (dimer of dimers) interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239942"
     gene            59122..59376
                     /gene="rpsR1"
                     /locus_tag="Rv0055"
                     /gene_synonym="rpsR"
                     /db_xref="GeneID:887022"
     CDS             59122..59376
                     /gene="rpsR1"
                     /locus_tag="Rv0055"
                     /gene_synonym="rpsR"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="YP_177688.1"
                     /db_xref="GeneID:887022"
                     /translation="MAKSSKRRPAPEKPVKTRKCVFCAKKDQAIDYKDTALLRTYISE
                     RGKIRARRVTGNCVQHQRDIALAVKNAREVALLPFTSSVR"
     misc_feature    59134..59367
                     /gene="rpsR1"
                     /locus_tag="Rv0055"
                     /gene_synonym="rpsR"
                     /note="30S ribosomal protein S18; Reviewed; Region: rpsR;
                     PRK00391"
                     /db_xref="CDD:178997"
     gene            59409..59867
                     /gene="rplI"
                     /locus_tag="Rv0056"
                     /db_xref="GeneID:887010"
     CDS             59409..59867
                     /gene="rplI"
                     /locus_tag="Rv0056"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00651"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="NP_214570.1"
                     /db_xref="GeneID:887010"
                     /translation="MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQ
                     KQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVA
                     AIKKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS"
     misc_feature    59409..59861
                     /gene="rplI"
                     /locus_tag="Rv0056"
                     /note="50S ribosomal protein L9; Reviewed; Region: rplI;
                     PRK00137"
                     /db_xref="CDD:234659"
     gene            59896..60417
                     /locus_tag="Rv0057"
                     /db_xref="GeneID:887008"
     CDS             59896..60417
                     /locus_tag="Rv0057"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214571.1"
                     /db_xref="GeneID:887008"
                     /translation="MPVVTAVGRRRGFAMPWVSTARSGAVMLANYSAGVCGRVSSPGL
                     NVRKMCLKANTPGAVTWLDTPKRFLSTQTASRCMAVNSSDVVTGRIDPQVLHTPLNTD
                     VDGYAHAMHSSINSGPLEYLPATFSVFPALGDVGDLGGGVGAATYALDRLSNMRSGAC
                     VGGGESPWRSLMT"
     gene            60396..63020
                     /gene="dnaB"
                     /locus_tag="Rv0058"
                     /db_xref="GeneID:887009"
     CDS             60396..63020
                     /gene="dnaB"
                     /locus_tag="Rv0058"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /inference="protein motif:PROSITE:PS00017"
                     /note="Contains an intein (position 61630..62838). This
                     protein undergoes a protein self splicing that involves a
                     post-translational excision of the intervening region
                     (intein) followed by peptide ligation. In the intein
                     section; belongs to the homing endonuclease family."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="NP_214572.1"
                     /db_xref="GeneID:887009"
                     /translation="MAVVDDLAPGMDSSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDA
                     IADVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRRIGGAPY
                     LHTLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQ
                     AEIYDVADRRLSEDFVALEDLLQPTMDEIDAIASSGGLARGVATGFTELDEVTNGLHP
                     GQMVIVAARPGVGKSTLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKL
                     SDMRSGRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKANLKLIV
                     VDYLQLMTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLNRGPEQRTDKKPML
                     ADLRESGCLTASTRILRADTGAEVAFGELMRSGERPMVWSLDERLRMVARPMINVFPS
                     GRKEVFRLRLASGREVEATGSHPFMKFEGWTPLAQLKVGDRIAAPRRVPEPIDTQRMP
                     ESELISLARMIGDGSCLKNQPIRYEPVDEANLAAVTVSAAHSDRAAIRDDYLAARVPS
                     LRPARQRLPRGRCTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAG
                     GSVRWDPTNGQGRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRLHIHG
                     AKDQVRFLRHVGVHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWAQVRNRLSAKQMM
                     DIQLHEPTMWKHSPSRSRPHRAEARIEDRAIHELARGDAYWDTVVEITSIGDQHVFDG
                     TVSGTHNFVANGISLHNSLEQDADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTK
                     TVTVAHQLHLSRFANMAR"
     misc_feature    60396..63017
                     /gene="dnaB"
                     /locus_tag="Rv0058"
                     /note="replicative DNA helicase; Validated; Region:
                     PRK07773"
                     /db_xref="CDD:236093"
     gene            63200..63892
                     /locus_tag="Rv0059"
                     /db_xref="GeneID:887006"
     CDS             63200..63892
                     /locus_tag="Rv0059"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214573.1"
                     /db_xref="GeneID:887006"
                     /translation="MITRYKPESGFVARSGGPDRKRPHDWIVWHFTHADNLPGIITAG
                     RLLADSAVTPTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSPMLYVVC
                     KGHSGYSGGAGPLVHLGVALGDIIDADLTWCASDGNAAASYTKFSRQVDTLGTFVDFD
                     LLCQRQWHNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYNTETMTRVRTLLDPVGG
                     VRKYVIKPGMYY"
     misc_feature    63284..63889
                     /locus_tag="Rv0059"
                     /note="Domain of unknown function (DUF4433); Region:
                     DUF4433; pfam14487"
                     /db_xref="CDD:316959"
     gene            63909..64967
                     /locus_tag="Rv0060"
                     /db_xref="GeneID:887004"
     CDS             63909..64967
                     /locus_tag="Rv0060"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214574.1"
                     /db_xref="GeneID:887004"
                     /translation="MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFT
                     AYEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRV
                     IRELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVE
                     GLRMTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFT
                     PGRYGPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAA
                     ADRVSAAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGR
                     IYSDDRIGVALDRILMTA"
     misc_feature    63909..64325
                     /locus_tag="Rv0060"
                     /note="Macro domain, Poa1p_like family. The macro domain
                     is a high-affinity ADP-ribose binding module found in a
                     variety of proteins as a stand-alone domain or in
                     combination with other domains like in histone macroH2A
                     and some PARPs (poly ADP-ribose...; Region:
                     Macro_Poa1p_like; cd02901"
                     /db_xref="CDD:239230"
     misc_feature    order(63930..63935,63972..63974,63993..63995,63999..64004,
                     64257..64259,64263..64271)
                     /locus_tag="Rv0060"
                     /note="ADP-ribose binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:239230"
     misc_feature    64170..64841
                     /locus_tag="Rv0060"
                     /note="O-acetyl-ADP-ribose deacetylase (regulator of RNase
                     III), contains Macro domain [Translation, ribosomal
                     structure and biogenesis]; Region: YmdB; COG2110"
                     /db_xref="CDD:225021"
     gene            complement(65012..65350)
                     /locus_tag="Rv0061c"
                     /db_xref="GeneID:14515843"
     CDS             complement(65012..65350)
                     /locus_tag="Rv0061c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_007408697.1"
                     /db_xref="GeneID:14515843"
                     /translation="MKLKFARLSTAILGCAAALVFPASVASADPPDPHQPDMTKGYCP
                     GGRWGFGDLAVCDGEKYPDGSFWHQWMQTWFTGPQFYFDCVSGGEPLPGPPPPGGCGG
                     AIPSEQPNAP"
     gene            65552..66694
                     /gene="celA1"
                     /locus_tag="Rv0062"
                     /gene_synonym="cel6; celA"
                     /db_xref="GeneID:887007"
     CDS             65552..66694
                     /gene="celA1"
                     /locus_tag="Rv0062"
                     /gene_synonym="cel6; celA"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="belongs to cellulase family B (family 6 of glycosyl
                     hydrolases)"
                     /codon_start=1
                     /transl_table=11
                     /product="cellulase CelA"
                     /protein_id="YP_177689.1"
                     /db_xref="GeneID:887007"
                     /translation="MTRRTGQRWRGTLPGRRPWTRPAPATCRRHLAFVELRHYFARVM
                     SSAIGSVARWIVPLLGVAAVASIGVIADPVRVVRAPALILVDAANPLAGKPFYVDPAS
                     AAMVAARNANPPNAELTSVANTPQSYWLDQAFPPATVGGTVARYTGAAQAAGAMPVLT
                     LYGIPHRDCGSYASGGFATGTDYRGWIDAVASGLGSSPATIIVEPDALAMADCLSPDQ
                     RQERFDLVRYAVDTLTRDPAAAVYVDAGHSRWLSAEAMAARLNDVGVGRARGFSLNVS
                     NFYTTDEEIGYGEAISGLTNGSHYVIDTSRNGAGPAPDAPLNWCNPSGRALGAPPTTA
                     TAGAHADAYLWIKRPGESDGTCGRGEPQAGRFVSQYAIDLAHNAGQ"
     misc_feature    65552..>66691
                     /gene="celA1"
                     /locus_tag="Rv0062"
                     /gene_synonym="cel6; celA"
                     /note="Cellulase/cellobiase CelA1 [Carbohydrate transport
                     and metabolism]; Region: CelA1; COG5297"
                     /db_xref="CDD:227616"
     gene            66923..68362
                     /locus_tag="Rv0063"
                     /db_xref="GeneID:886999"
     CDS             66923..68362
                     /locus_tag="Rv0063"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00862"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214577.1"
                     /db_xref="GeneID:886999"
                     /translation="MAREISRQTFLRGAAGALAAGAVFGSVRATADPAASGWEALSSA
                     LGGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAFAAANNLKVAP
                     RGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTVTPATGLYAMHQVLAAAGRG
                     IPTGTCPTVGVAGHALGGGLGANSRHAGLLCDQLTSASVVLPSGQAVTASATDHPDLF
                     WALRGGGGGNFGVTTSLTFATFPSGDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSW
                     ALADATVDPLGTHCRILATCPAGSGGSVAAAIVSAVGTQPTGTENHTFNYLDLVRYLA
                     VGNLNPSPLGYVGGSDVFTTITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVS
                     PGATAFPWRRQSALVQWYVETSGSPSEATSWLNTAHQAVRAYSVGGYVNYLEVNQPPA
                     RYFGPNLSRLSAVRQKYDPSRVMFSGLNF"
     misc_feature    67040..68359
                     /locus_tag="Rv0063"
                     /note="FAD/FMN-containing dehydrogenase [Energy production
                     and conversion]; Region: GlcD; COG0277"
                     /db_xref="CDD:223354"
     gene            68418..68579
                     /locus_tag="Rv0063a"
                     /db_xref="GeneID:19394667"
     CDS             68418..68579
                     /locus_tag="Rv0063a"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_009030026.1"
                     /db_xref="GeneID:19394667"
                     /translation="MIMELSVSVIAGLVIALLAAITPAAGERPESRRQALANAAEAGE
                     HPATSPLRR"
     gene            68620..71559
                     /locus_tag="Rv0064"
                     /db_xref="GeneID:886996"
     CDS             68620..71559
                     /locus_tag="Rv0064"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214578.1"
                     /db_xref="GeneID:886996"
                     /translation="METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWL
                     WFGEVGFRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDPVA
                     PLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIVDPEFGYDIGF
                     FVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAARVQLAVFAG
                     AVVLLKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFT
                     AIFLRDLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATRE
                     AYRIGGDWVQYRSYPGIGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFS
                     FAEILDIDRYRIDGELQDYIVGVRELSPKSLTGNQTDWINKHTVYTHGNGFVAAPANR
                     VNAAARGAENISDSNSGYPIYAVSDIASLGSGRQVIPVEQPRVYYGEVIAQADPDYAI
                     VGGAPGSAPREYDTDTSKYTYTGAGGVSIGNWFNRTVFATKVAQHKFLFSREIGSESK
                     VLIHRDPKERVQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPV
                     TSPTGIVRQGKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSED
                     QIPDELRAHFRYPEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNNANATQPP
                     FYVLVGDQQSAQPSFRLASAMVGYNREFLSAYISAHSDPANYGKLTVLELPTDTLTQG
                     PQQIQNSMISDTRVASERTLLERSNRIHYGNLLSLPIADGGVLYVEPLYTERISTSPS
                     SSTFPQLSRVLVSVREPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATARGGDAASAP
                     PPGAGGPAPPQAVPPPRTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAID
                     AAETPGG"
     misc_feature    68620..71556
                     /locus_tag="Rv0064"
                     /note="hypothetical protein; Provisional; Region:
                     PRK12438"
                     /db_xref="CDD:171499"
     misc_feature    68659..71547
                     /locus_tag="Rv0064"
                     /note="Uncharacterized membrane protein, UPF0182 family
                     [Function unknown]; Region: COG1615"
                     /db_xref="CDD:224531"
     gene            71589..71828
                     /gene="vapB1"
                     /locus_tag="Rv0064A"
                     /db_xref="GeneID:14515844"
     CDS             71589..71828
                     /gene="vapB1"
                     /locus_tag="Rv0064A"
                     /note="part of toxin-antitoxin (TA) operon with Rv0065"
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin VapB1"
                     /protein_id="YP_007408701.1"
                     /db_xref="GeneID:14515844"
                     /translation="MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRD
                     KAEAIEILEQALASTASPGISRETIEASRRELRGG"
     gene            71821..72222
                     /gene="vapC1"
                     /locus_tag="Rv0065"
                     /db_xref="GeneID:886993"
     CDS             71821..72222
                     /gene="vapC1"
                     /locus_tag="Rv0065"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:22539524]"
                     /note="toxin, part of toxin-antitoxin (TA) operon with
                     Rv0064A"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease VapC1"
                     /protein_id="NP_214579.1"
                     /db_xref="GeneID:886993"
                     /translation="MDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEV
                     GHALRRAVLSDEISEEQARAALDALPYLIDNRYPHSPRLIEYTWQLRHNVTFYDALYV
                     ALATALDVPLLTGDSRLAAAPGLPCEIKLVR"
     misc_feature    71863..72219
                     /gene="vapC1"
                     /locus_tag="Rv0065"
                     /note="Predicted nucleic acid-binding protein, contains
                     PIN domain [General function prediction only]; Region:
                     COG4113"
                     /db_xref="CDD:226598"
     misc_feature    order(71929..71937,71941..71958,71962..71970,72004..72009,
                     72013..72018,72025..72027,72070..72072,72076..72081,
                     72085..72090,72100..72114,72118..72120,72163..72174,
                     72184..72186)
                     /gene="vapC1"
                     /locus_tag="Rv0065"
                     /note="homotetrameric interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:189043"
     misc_feature    72166..72168
                     /gene="vapC1"
                     /locus_tag="Rv0065"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:189043"
     gene            complement(72274..74511)
                     /gene="icd2"
                     /locus_tag="Rv0066c"
                     /db_xref="GeneID:887016"
     CDS             complement(72274..74511)
                     /gene="icd2"
                     /locus_tag="Rv0066c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to the monomeric-type family of IDH. Note
                     that in H37Rv"
                     /codon_start=1
                     /transl_table=11
                     /product="isocitrate dehydrogenase"
                     /protein_id="NP_214580.1"
                     /db_xref="GeneID:887016"
                     /translation="MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDI
                     SVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKEL
                     QDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKH
                     PHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPL
                     DDGDVIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIF
                     YKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMV
                     DSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEII
                     NFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLT
                     ENVEAGDIWRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTY
                     LKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSA
                     KMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKT
                     GNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQ
                     LAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAAL
                     EAVQG"
     misc_feature    complement(72292..74493)
                     /gene="icd2"
                     /locus_tag="Rv0066c"
                     /note="Monomeric isocitrate dehydrogenase; Region: IDH;
                     pfam03971"
                     /db_xref="CDD:309190"
     gene            complement(74629..75198)
                     /locus_tag="Rv0067c"
                     /db_xref="GeneID:886991"
     CDS             complement(74629..75198)
                     /locus_tag="Rv0067c"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214581.1"
                     /db_xref="GeneID:886991"
                     /translation="MAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAG
                     VGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGA
                     TDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLV
                     GCQAMQSYNAELAAKVTDVALDGLRANRK"
     misc_feature    complement(75007..75141)
                     /locus_tag="Rv0067c"
                     /note="Bacterial regulatory proteins, tetR family; Region:
                     TetR_N; pfam00440"
                     /db_xref="CDD:306858"
     gene            75301..76212
                     /locus_tag="Rv0068"
                     /db_xref="GeneID:886989"
     CDS             75301..76212
                     /locus_tag="Rv0068"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214582.1"
                     /db_xref="GeneID:886989"
                     /translation="MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLA
                     VRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAG
                     VMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIH
                     FDDLQWERRYRRVAAYGQAKLANLLFTYELQRRLAPGGTTIAVASHPGVSNTEVVRNM
                     PRPLVAVAAILAPLMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASS
                     AQSHDEQLQRRLWAVSEELTGVVYPVG"
     misc_feature    75301..76206
                     /locus_tag="Rv0068"
                     /note="short chain dehydrogenase; Provisional; Region:
                     PRK06197"
                     /db_xref="CDD:235737"
     gene            complement(76237..77622)
                     /gene="sdaA"
                     /locus_tag="Rv0069c"
                     /db_xref="GeneID:886986"
     CDS             complement(76237..77622)
                     /gene="sdaA"
                     /locus_tag="Rv0069c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to the iron-sulfur dependent L-serine
                     dehydratase family."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine dehydratase"
                     /protein_id="NP_214583.1"
                     /db_xref="GeneID:886986"
                     /translation="MTISVFDLFTIGIGPSSSHTVGPMRAANQFVVALRRRGHLDDLE
                     AMRVDLFGSLAATGAGHGTMSAILLGLEGCQPETITTEHKERRLAEIAASGVTRIGGV
                     IPVPLTERDIDLHPDIVLPTHPNGMTFTAAGPHGRVLATETYFSVGGGFIVTEQTSGN
                     SGQHPCSVALPYVSAQELLDICDRLDVSISEAALRNETCCRTENEVRAALLHLRDVMV
                     ECEQRSIAREGLLPGGLRVRRRAKVWYDRLNAEDPTRKPEFAEDWVNLVALAVNEENA
                     SGGRVVTAPTNGAAGIVPAVLHYAIHYTSAGAGDPDDVTVRFLLTAGAIGSLFKERAS
                     ISGAEVGCQGEVGSAAAMAAAGLAEILGGTPRQVENAAEIAMEHSLGLTCDPIAGLVQ
                     IPCIERNAISAGKAINAARMALRGDGIHRVTLDQVIDTMRATGADMHTKYKETSAGGL
                     AINVAVNIVEC"
     misc_feature    complement(76261..77616)
                     /gene="sdaA"
                     /locus_tag="Rv0069c"
                     /note="L-serine dehydratase, iron-sulfur-dependent, single
                     chain form; Region: sda_mono; TIGR00720"
                     /db_xref="CDD:273233"
     gene            complement(77619..78896)
                     /gene="glyA2"
                     /locus_tag="Rv0070c"
                     /db_xref="GeneID:886983"
     CDS             complement(77619..78896)
                     /gene="glyA2"
                     /locus_tag="Rv0070c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:12913008]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00096"
                     /note="Belongs to the ShmT family. Cofactor: pyridoxal
                     phosphate."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="NP_214584.1"
                     /db_xref="GeneID:886983"
                     /translation="MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVM
                     QAQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATAN
                     AATMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVA
                     EAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPV
                     PHAHVVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLEHVIAAKATAFK
                     MAAQPEFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDG
                     QQAEDRLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAA
                     ALTATNDDQLGPLRAQVQRLAARYPLYPELHRT"
     misc_feature    complement(77631..78890)
                     /gene="glyA2"
                     /locus_tag="Rv0070c"
                     /note="serine hydroxymethyltransferase; Reviewed; Region:
                     glyA; PRK00011"
                     /db_xref="CDD:234571"
     misc_feature    complement(order(78051..78053,78105..78107,78480..78485,
                     78588..78590,78609..78611,78654..78656,78678..78683,
                     78735..78737,78789..78791,78804..78806,78831..78836,
                     78855..78857,78861..78863))
                     /gene="glyA2"
                     /locus_tag="Rv0070c"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:99733"
     misc_feature    complement(order(77796..77798,78189..78191,78207..78212,
                     78285..78287,78294..78296,78369..78371,78519..78521,
                     78600..78605,78702..78704,78732..78734,78792..78794))
                     /gene="glyA2"
                     /locus_tag="Rv0070c"
                     /note="glycine-pyridoxal phosphate binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:99733"
     misc_feature    complement(order(77796..77798,78207..78209,78519..78521,
                     78792..78794))
                     /gene="glyA2"
                     /locus_tag="Rv0070c"
                     /note="active site"
                     /db_xref="CDD:99733"
     misc_feature    complement(order(77844..77846,78129..78131,78516..78518,
                     78522..78524,78534..78536,78705..78707,78726..78728))
                     /gene="glyA2"
                     /locus_tag="Rv0070c"
                     /note="folate binding site [chemical binding]; other site"
                     /db_xref="CDD:99733"
     gene            79486..80193
                     /locus_tag="Rv0071"
                     /db_xref="GeneID:886988"
     CDS             79486..80193
                     /locus_tag="Rv0071"
                     /note="group II intron maturase family. Contains 5 VDP
                     repeats at N-terminus."
                     /codon_start=1
                     /transl_table=11
                     /product="maturase"
                     /protein_id="NP_214585.1"
                     /db_xref="GeneID:886988"
                     /translation="MSSITVSVDPVDPVDPVDPVDPVDAVVAAGSDGLTVARIESEIG
                     ALEFLNELRTELKSGQFRPQPVRERKIPKPGGLGKVRRLGIPTVADRVVQAALKLVLE
                     PIFETDFEPVSYGFRPARRAHDTIAEIHLFGTQEYRWVLDADIKACFDRIDHADLMDR
                     VRHRIKDKRVLRLVNWQRIRHRWNWTDVRRWLTDPTGRWHPISADGITLFNPAAVPIR
                     RYRYRGNTIPTPWTQAV"
     misc_feature    79573..>80064
                     /locus_tag="Rv0071"
                     /note="Reverse transcriptase (RNA-dependent DNA
                     polymerase); Region: RVT_1; cl26764"
                     /db_xref="CDD:331585"
     repeat_region   79507..79551
                     /locus_tag="Rv0071"
                     /note="5 x 9 bp GTGGACCCG repeats"
     repeat_region   80236..80550
                     /note="(MTV030.15), len: 315 nt. Probable REP'-1
                     pseudogene fragment"
     gene            80624..81673
                     /locus_tag="Rv0072"
                     /db_xref="GeneID:886984"
     CDS             80624..81673
                     /locus_tag="Rv0072"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21969609]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine ABC transporter permease"
                     /protein_id="NP_214586.1"
                     /db_xref="GeneID:886984"
                     /translation="MLFAALRDMQWRKRRLVITIISTGLIFGMTLVLTGLANGFRVEA
                     RHTVDSMGVDVFVVRSGAAGPFLGSIPFPDVDLARVAAEPGVMAAAPLGSVGTIMKEG
                     TSTRNVTVFGAPEHGPGMPRVSEGRSPSKPDEVAASSTMGRHLGDTVEVGARRLRVVG
                     IVPNSTALAKIPNVFLTTEGLQKLAYNGQPNITSIGIIGMPRQLPEGYQTFDRVGAVN
                     DLVRPLKVAVNSISIVAVLLWIVAVLIVGSVVYLSALERLRDFAVFKAIGTPTRSIMA
                     GLALQALVIALLAAVVGVVLAQVLAPLFPMIVAVPVGAYLALPVAAIVIGLFASVAGL
                     KRVVTVDPAQAFGGP"
     misc_feature    80624..81661
                     /locus_tag="Rv0072"
                     /note="FtsX-like permease family; Region: FtsX; cl27391"
                     /db_xref="CDD:332212"
     gene            81676..82668
                     /locus_tag="Rv0073"
                     /db_xref="GeneID:886977"
     CDS             81676..82668
                     /locus_tag="Rv0073"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00211"
                     /inference="protein motif:PROSITE:PS00889"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine ABC transporter ATP-binding protein"
                     /protein_id="NP_214587.1"
                     /db_xref="GeneID:886977"
                     /translation="MGDLSIQNLVVEYYSGGYALRPINGLNLDVAAGSLVMLLGPSGC
                     GKTTLLSCLGGILRPKSGAIKFDEVDITTLQGAELANYRRNKVGIVFQAFNLVPSLTA
                     VENVMVPLRSAGMSRRASRRRAEELLARVNLAERMNHRPGDLSGGQQQRVAVARAIAL
                     DPPLILADEPTAHLDFIQVEEVLRLIRELADGERVVVVATHDSRMLPMADRVVELTPD
                     FAETNRPPETVHLQAGEVLFEQSTMGDLIYVVSEGEFEIVHELADGGEELVKVAGPGD
                     YFGEIGVLFHLPRSATVRARSDATAVGYTVQAFRERLGVGGLRDLIEHRALAND"
     misc_feature    81685..82320
                     /locus_tag="Rv0073"
                     /note="ABC-type lipoprotein export system, ATPase
                     component [Cell wall/membrane/envelope biogenesis];
                     Region: LolD; COG1136"
                     /db_xref="CDD:224059"
     misc_feature    82354..82617
                     /locus_tag="Rv0073"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(82510..82515,82540..82548)
                     /locus_tag="Rv0073"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     gene            82748..83983
                     /locus_tag="Rv0074"
                     /db_xref="GeneID:886976"
     CDS             82748..83983
                     /locus_tag="Rv0074"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214588.1"
                     /db_xref="GeneID:886976"
                     /translation="MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRIS
                     AVDFAGSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAGDPHAVLVGRARR
                     HAAAALRSGITTIRDLGDRDYAALALREEYRQKTTVGPELVVSGPPLTRSGGHCWFLG
                     GVADSVEELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQ
                     VGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVWCGMTI
                     PRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSR
                     HGFTSTEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVW
                     RSGTQVPLQASAVGYNTPS"
     misc_feature    82844..>82978
                     /locus_tag="Rv0074"
                     /note="Superfamily of metallo-dependent hydrolases (also
                     called amidohydrolase superfamily) is a large group of
                     proteins that show conservation in their 3-dimensional
                     fold (TIM barrel) and in details of their active site. The
                     vast majority of the members have a...; Region:
                     metallo-dependent_hydrolases; cl00281"
                     /db_xref="CDD:320877"
     misc_feature    82922..83902
                     /locus_tag="Rv0074"
                     /note="Metallo-dependent hydrolases, subgroup A is part of
                     the superfamily of metallo-dependent hydrolases, a large
                     group of proteins that show conservation in their
                     3-dimensional fold (TIM barrel) and in details of their
                     active site. The vast majority of the...; Region:
                     Met_dep_hydrolase_A; cd01299"
                     /db_xref="CDD:238624"
     misc_feature    order(82967..82969,82973..82975,83423..83425,83483..83485,
                     83684..83686)
                     /locus_tag="Rv0074"
                     /note="active site"
                     /db_xref="CDD:238624"
     gene            83996..85168
                     /locus_tag="Rv0075"
                     /db_xref="GeneID:886982"
     CDS             83996..85168
                     /locus_tag="Rv0075"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="class-II pyridoxal-phosphate-dependent
                     aminotransferases (MALY/PATB subfamily)"
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase"
                     /protein_id="NP_214589.1"
                     /db_xref="GeneID:886982"
                     /translation="MQDSIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPA
                     VLDGVRACVDNEEFGYPPLGEDSLPRATADWCRQRYGWCPRPDWVRVVPDVLKGMEVV
                     VEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQQDSGRYLLDLDALQAAFVR
                     GAGSVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGSRHVAAASV
                     SEAAAEVVVTLVSASKGWNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRAN
                     IAAYHHGESWLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVDFRALALPS
                     EPAEYLLSKAKVALSPGIPFGAAVGSGFARLNFATTRAILDRAIEAIAAALRDIID"
     misc_feature    84008..85162
                     /locus_tag="Rv0075"
                     /note="Bifunctional PLP-dependent enzyme with
                     beta-cystathionase and maltose regulon repressor
                     activities [Amino acid transport and metabolism, General
                     function prediction only]; Region: MalY; COG1168"
                     /db_xref="CDD:224090"
     gene            complement(85183..85572)
                     /locus_tag="Rv0076c"
                     /db_xref="GeneID:886992"
     CDS             complement(85183..85572)
                     /locus_tag="Rv0076c"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214590.1"
                     /db_xref="GeneID:886992"
                     /translation="MPAVTTPSNHWGDERRKLSHQPPVRGQILGRRQARRLSQHFARV
                     GVEAPPKRLQEMLLGAPAADEEWTDVKFALIVTQLNHEKRVAKFHRLQRRATHSLICL
                     GLVLVALNFLICLAYIFFSLTQHAAAL"
     gene            complement(85636..86466)
                     /locus_tag="Rv0077c"
                     /db_xref="GeneID:886969"
     CDS             complement(85636..86466)
                     /locus_tag="Rv0077c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214591.1"
                     /db_xref="GeneID:886969"
                     /translation="MSTIDISAGTIHYEATGPETGRPVVFVHGYMMGGQLWRRVSERL
                     AGRGLRCIAPTWPLGAHPKPLRPGADQTIGGVAGIVADVLAALELKDVVLVGNDTGGV
                     VTQLVAVHYPERLGALVLTSCDAFEHFPPPILKPVILAAKSATLFRAAIQVMRAPAAR
                     NRAYAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLRTEVTTAVAARLPEFDKP
                     ALIAWSADDVFFALENGQRLAATIPRARFEVIEGARTFSMVDSPDRLADQLSTVAVRT
                     "
     misc_feature    complement(85660..86466)
                     /locus_tag="Rv0077c"
                     /note="Pimeloyl-ACP methyl ester carboxylesterase
                     [Coenzyme transport and metabolism, General function
                     prediction only]; Region: MhpC; COG0596"
                     /db_xref="CDD:223669"
     gene            86528..87133
                     /locus_tag="Rv0078"
                     /db_xref="GeneID:886990"
     CDS             86528..87133
                     /locus_tag="Rv0078"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214592.1"
                     /db_xref="GeneID:886990"
                     /translation="MEIKRRTQEERSAATREALITGARKLWGLRGYAEVGTPEIATEA
                     GVTRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLE
                     VSGDPEVRQLILLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPVRPLA
                     QVLIGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG"
     misc_feature    86582..86716
                     /locus_tag="Rv0078"
                     /note="Bacterial regulatory proteins, tetR family; Region:
                     TetR_N; pfam00440"
                     /db_xref="CDD:306858"
     gene            complement(87208..87801)
                     /locus_tag="Rv0078A"
                     /db_xref="GeneID:3205053"
     CDS             complement(87208..87801)
                     /locus_tag="Rv0078A"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_177616.1"
                     /db_xref="GeneID:3205053"
                     /translation="MNAVESTLRRVAKDLTGLRQRWALVGGFAVSARSEPRFTRDVDI
                     VVAVANDDAAESLVRQLLTQQYHLLASVEQDAARRLAAVRLGATADTAANVVVDLLFA
                     SCGIEPEIAEAAEEIEILPDLVAPVATTAHLIAMKLLARDDDRRPQDRSDLRALVDAA
                     SPQDIQDARKAIELITLRGFHRDRDLAAEWTRLAAKW"
     gene            complement(87798..88004)
                     /locus_tag="Rv0078B"
                     /db_xref="GeneID:14515845"
     CDS             complement(87798..88004)
                     /locus_tag="Rv0078B"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_007408717.1"
                     /db_xref="GeneID:14515845"
                     /translation="MAVSVAAQKLRLALDMYEVGEQMQRMRLGRERPNADVVEIEAAI
                     DAWRMTRPGAEEGDSAGPTSTRFT"
     gene            88204..89025
                     /locus_tag="Rv0079"
                     /db_xref="GeneID:886995"
     CDS             88204..89025
                     /locus_tag="Rv0079"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="possible vaccine candidate (See Zvi et al.,2008
                     PMID:8505592)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214593.1"
                     /db_xref="GeneID:886995"
                     /translation="MEPKRSRLVVCAPEPSHAREFPDVAVFSGGRANASQAERLARAV
                     GRVLADRGVTGGARVRLTMANCADGPTLVQINLQVGDTPLRAQAATAGIDDLRPALIR
                     LDRQIVRASAQWCPRPWPDRPRRRLTTPAEALVTRRKPVVLRRATPLQAIAAMDAMDY
                     DVHLFTDAETGEDAVVYRAGPSGLRLARQHHVFPPGWSRCRAPAGPPVPLIVNSRPTP
                     VLTEAAAVDRAREHGLPFLFFTDQATGRGQLLYSRYDGNLGLITPTGDGVADGLA"
     misc_feature    88606..88737
                     /locus_tag="Rv0079"
                     /note="Sigma 54 modulation/S30EA ribosomal protein C
                     terminus; Region: Ribosom_S30AE_C; pfam16321"
                     /db_xref="CDD:318528"
     gene            89022..89480
                     /locus_tag="Rv0080"
                     /db_xref="GeneID:886966"
     CDS             89022..89480
                     /locus_tag="Rv0080"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214594.1"
                     /db_xref="GeneID:886966"
                     /translation="MSPGSRRASPQSAREVVELDRDEAMRLLASVDHGRVVFTRAALP
                     AIRPVNHLVVDGRVIGRTRLTAKVSVAVRSSADAGVVVAYEADDLDPRRRTGWSVVVT
                     GLATEVSDPEQVARYQRLLHPWVNMAMDTVVAIEPEIVTGIRIVADSRTP"
     misc_feature    89079..89453
                     /locus_tag="Rv0080"
                     /note="Pyridoxamine 5'-phosphate oxidase; Region:
                     Pyridox_ox_2; pfam12900"
                     /db_xref="CDD:315559"
     gene            89575..89919
                     /locus_tag="Rv0081"
                     /db_xref="GeneID:887012"
     CDS             89575..89919
                     /locus_tag="Rv0081"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_214595.1"
                     /db_xref="GeneID:887012"
                     /translation="MESEPLYKLKAEFFKTLAHPARIRILELLVERDRSVGELLSSDV
                     GLESSNLSQQLGVLRRAGVVAARRDGNAMIYSIAAPDIAELLAVARKVLARVLSDRVA
                     VLEDLRAGGSAT"
     misc_feature    89614..89817
                     /locus_tag="Rv0081"
                     /note="Arsenical Resistance Operon Repressor and similar
                     prokaryotic, metal regulated homodimeric repressors. ARSR
                     subfamily of helix-turn-helix bacterial transcription
                     regulatory proteins (winged helix topology). Includes
                     several proteins that appear to...; Region: HTH_ARSR;
                     cd00090"
                     /db_xref="CDD:238042"
     misc_feature    order(89617..89622,89632..89640,89677..89685,89713..89724,
                     89728..89733,89740..89745,89749..89754,89770..89778,
                     89791..89799)
                     /locus_tag="Rv0081"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:238042"
     gene            89924..90403
                     /locus_tag="Rv0082"
                     /db_xref="GeneID:886968"
     CDS             89924..90403
                     /locus_tag="Rv0082"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214596.2"
                     /db_xref="GeneID:886968"
                     /translation="MGWVAKIFRVGRVVEPAAPLPAAIAEPPAGVRGSLQIRHVDAGS
                     CNGCEVEISGAFGPVYDAERFGARLVASPRHADALLVTGVVTHNMAGPLRKTLEATPR
                     PRVVIACGDCALNRGVFADAYGVVGAVGEVVPVDVEIAGCPPTPAAIMAALRSVTGK"
     misc_feature    90011..90400
                     /locus_tag="Rv0082"
                     /note="Ni,Fe-hydrogenase III small subunit [Energy
                     production and conversion]; Region: HycG; COG3260"
                     /db_xref="CDD:225799"
     gene            90400..92322
                     /locus_tag="Rv0083"
                     /db_xref="GeneID:886965"
     CDS             90400..92322
                     /locus_tag="Rv0083"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214597.1"
                     /db_xref="GeneID:886965"
                     /translation="MTAAPTAGGVVTSGVGVAGVGVGLLGMFGPVRVVHVGWLLPLSG
                     VHIELDRLGGFFMALTGAVAAPVGCYLIGYVRREHLGRVPMAVVPLFVAAMLLVPAAG
                     SVTTFLLAWELMAIASLILVLSEHARPQVRSAGLWYAVMTQLGFIAILVGLVVLAAAG
                     GSDRFAGLGAVCDGVRAAVFMLTLVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMSAA
                     MVNLGIYGIVRFDLQLLGPGPRWWGLALLAVGGTSALYGVLQASVAADLKRLLAYSTT
                     ENMGLITLALGAATLFADTGAYGPASIAAAAAMLHMIAHAAFKSLAFMAAGSVLAATG
                     LRDLDLLGGLARRMPATTVFFGVAALGACGLPLGAGFVSEWLLVQSLIHAAPGHDPIV
                     ALTTPLAVGVVALATGLSVAAMTKAFGIGFLARPRSTQAEAAREAPASMRAGMAIAAG
                     ACLVLAVAPLLVAPMVRRAAATLPAAQAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLA
                     AALAVAVLARWRFRRRPAPARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVLRPD
                     TDIEVTHTAESRYMAERITYRTAVADAIEQRLYTPVVGAVAAMAELLRRAHTGSVHRY
                     LAYGALGVLIVLVVAR"
     misc_feature    90517..92319
                     /locus_tag="Rv0083"
                     /note="Proton-conducting membrane transporter; Region:
                     Proton_antipo_M; cl27709"
                     /db_xref="CDD:332530"
     gene            92328..93278
                     /gene="hycD"
                     /locus_tag="Rv0084"
                     /gene_synonym="hevD"
                     /db_xref="GeneID:886959"
     CDS             92328..93278
                     /gene="hycD"
                     /locus_tag="Rv0084"
                     /gene_synonym="hevD"
                     /note="alternate gene name: hevD, formate
                     hydrogenlyase,integral membrane protein, belongs to the
                     complex I subunit 1 family."
                     /codon_start=1
                     /transl_table=11
                     /product="formate hydrogenlyase HycD"
                     /protein_id="NP_214598.1"
                     /db_xref="GeneID:886959"
                     /translation="MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRAGAGLLQPWR
                     DLLKQLGKQQITPAGTTIVFAAAPVIVAGTTLLIAAIAPLVATGSPLDPSADLFAVVG
                     LLFLGTVALTLAGIDTGTSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGAL
                     VASTIDHPGHVVSLAGVLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAG
                     PRLALVEWAAGMRLTVLLALLANLFLPWGIAGAAPTALDVLTGVVAVAAKVAILAVLL
                     ATFEVFLAKLRLFRVPELLAGSFLLALLAVTAANFFTVGA"
     misc_feature    92328..93224
                     /gene="hycD"
                     /locus_tag="Rv0084"
                     /gene_synonym="hevD"
                     /note="Formate hydrogenlyase subunit 4 [Energy production
                     and conversion]; Region: HyfC; COG0650"
                     /db_xref="CDD:223723"
     gene            93289..93951
                     /gene="hycP"
                     /locus_tag="Rv0085"
                     /db_xref="GeneID:886973"
     CDS             93289..93951
                     /gene="hycP"
                     /locus_tag="Rv0085"
                     /note="belongs to NADH-ubiquinone/plastoquinone
                     oxidoreductase chain 4L superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="hydrogenase HycP"
                     /protein_id="NP_214599.1"
                     /db_xref="GeneID:886973"
                     /translation="MSNANFSILVDFAAGGLVLASVLIVWRRDLRAIVRLLAWQGAAL
                     AAIPLLRGIRDNDRALIAVGIAVLALRALVLPWLLARAVGAEAAAQREATPLVNTASS
                     LLITAGLTLTAFAITQPVVNLEPGVTINAVPAAFAVVLIALFVMTTRLHAVSQAAGFL
                     MLDNGIAATAFLLTAGVPLIVELGASLDVLFAVIVIGVLTGRLRRIFGDADLDKLREL
                     RD"
     misc_feature    93295..93948
                     /gene="hycP"
                     /locus_tag="Rv0085"
                     /note="Hydrogenase-4 membrane subunit HyfE [Energy
                     production and conversion]; Region: HyfE; COG4237"
                     /db_xref="CDD:226688"
     gene            93951..95417
                     /gene="hycQ"
                     /locus_tag="Rv0086"
                     /db_xref="GeneID:886963"
     CDS             93951..95417
                     /gene="hycQ"
                     /locus_tag="Rv0086"
                     /note="belongs to the NADH-Ubiquinone/plastoquinone
                     (complex I) superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="hydrogenase HycQ"
                     /protein_id="NP_214600.1"
                     /db_xref="GeneID:886963"
                     /translation="MTGLLLAAILAPLAASIASLITGWRRTTATLTALSATTVLACAV
                     AMGFWMGSGAQFGLGGLLRADALTVVMLVVIGIVGTLATAASIGYIDTELAHGHIDGR
                     SARLYGVLTPAFLCAMVLAVCANNIGVIWVAIEATTVITAFLVGHRRTRTALEATWKY
                     VVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLL
                     IGYGAKAGLFPFHTWLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAY
                     LRNGLLVVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLL
                     HVLAHGIGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVGLIVLLGLPPF
                     AMFASELAIARSLANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPAITVP
                     ATAAAALMVGIVVSAALGITAGPLADLLGIAASNVGLP"
     misc_feature    94017..95408
                     /gene="hycQ"
                     /locus_tag="Rv0086"
                     /note="Proton-conducting membrane transporter; Region:
                     Proton_antipo_M; cl27709"
                     /db_xref="CDD:332530"
     gene            95414..96892
                     /gene="hycE"
                     /locus_tag="Rv0087"
                     /gene_synonym="hevE"
                     /db_xref="GeneID:886956"
     CDS             95414..96892
                     /gene="hycE"
                     /locus_tag="Rv0087"
                     /gene_synonym="hevE"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="alternate gene name: hevE, formate hydrogenlyase,
                     belongs to the complex I 49 kDa subunit family."
                     /codon_start=1
                     /transl_table=11
                     /product="formate hydrogenase HycE"
                     /protein_id="NP_214601.1"
                     /db_xref="GeneID:886956"
                     /translation="MMSASWLRHRVSERGLIATAEQLWADSFRLALVAAHDDGDSLRV
                     VYLFLAGYPDRRVELEYVVPADNPEIRSLAYLSFPAGRFEREMADLYGIRPVGHPKPR
                     RLVRHAHWPDWHPMRTDAGPAPEFTDTGAFPFLAVEGPGVYEIPVGPVHAGLIEPGHF
                     RFSVAGETIVRLKARLWFVHRGIEKLFHGRPATAAVDLAERISGDTSAAHALAHSLAI
                     EDALGIELPHEVHRLRALIVELERLYNHAADLGALANDVGYSLANAHAQRIRENLLRR
                     NAAVTGHRLLRGAIRAGGVALRALPDTDELAALAVDLAEVATLTLANSVVYDRFAGTA
                     VLHPDDASALGCLGYVARASGLRSDARVEHPTIVLPITEIGAPDGDVLARYTVRRDEF
                     AASAALAQHIVESHTGPIEYAATLHPVGAPSSGIGIVEGWRGTIVHRVEIDVDGRITR
                     AKVVDPSWFNWPALPVAMADTIVPDFPLANKSFNQSYAGNDL"
     misc_feature    95414..95806
                     /gene="hycE"
                     /locus_tag="Rv0087"
                     /gene_synonym="hevE"
                     /note="Respiratory-chain NADH dehydrogenase, 30 Kd
                     subunit; Region: Complex1_30kDa; cl19197"
                     /db_xref="CDD:327518"
     misc_feature    95816..96889
                     /gene="hycE"
                     /locus_tag="Rv0087"
                     /gene_synonym="hevE"
                     /note="Ni,Fe-hydrogenase III large subunit [Energy
                     production and conversion]; Region: HycE2; cl27707"
                     /db_xref="CDD:332528"
     gene            96927..97601
                     /locus_tag="Rv0088"
                     /db_xref="GeneID:886954"
     CDS             96927..97601
                     /locus_tag="Rv0088"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="belongs to the SRPBCC ligand-binding domain
                     superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="polyketide cyclase/dehydrase"
                     /protein_id="NP_214602.1"
                     /db_xref="GeneID:886954"
                     /translation="MSVYKHAPSRVRLRQTRSTVVKGRSGSLSWRRVRTGDLGLAVWG
                     GREEYRAVKPGTPGIQPKGDMMTVTVVDAGPGRVSRSVEVAAPAAELFAIVADPRRHR
                     ELDGSGTVRGNIKVPAKLVVGSKFSTKMKLFGLPYRITSRVTALKPNELVEWSHPLGH
                     RWRWEFESLSPTLTRVTETFDYHAAGAIKNGLKFYEMTGFAKSNAAGIEATLAKLSDQ
                     YARGRA"
     misc_feature    97155..97568
                     /locus_tag="Rv0088"
                     /note="Ligand-binding SRPBCC domain of an uncharacterized
                     subfamily of proteins; Region: SRPBCC_7; cd07825"
                     /db_xref="CDD:176867"
     misc_feature    order(97158..97160,97164..97166,97170..97172,97197..97205,
                     97209..97214,97245..97247,97278..97280,97284..97286,
                     97290..97292,97296..97298,97347..97349,97353..97355,
                     97371..97373,97377..97379,97416..97421,97425..97427,
                     97431..97433,97452..97454,97458..97460,97464..97466,
                     97470..97472,97506..97520,97524..97532,97536..97544,
                     97551..97553)
                     /locus_tag="Rv0088"
                     /note="putative hydrophobic ligand binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:176867"
     gene            97758..98351
                     /locus_tag="Rv0089"
                     /db_xref="GeneID:886949"
     CDS             97758..98351
                     /locus_tag="Rv0089"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="Belongs to the methyltransferase superfamily."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase"
                     /protein_id="NP_214603.1"
                     /db_xref="GeneID:886949"
                     /translation="MDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRI
                     PYVTAVDIDAPVLRRAQTRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIEDTR
                     TALSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHSAPIKWP
                     PPQTLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV"
     misc_feature    97833..98105
                     /locus_tag="Rv0089"
                     /note="Methyltransferase domain; Region: Methyltransf_25;
                     pfam13649"
                     /db_xref="CDD:316196"
     misc_feature    order(97842..97862,97908..97913,97977..97985,98031..98033)
                     /locus_tag="Rv0089"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:100107"
     gene            98480..99250
                     /locus_tag="Rv0090"
                     /db_xref="GeneID:886961"
     CDS             98480..99250
                     /locus_tag="Rv0090"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214604.1"
                     /db_xref="GeneID:886961"
                     /translation="MAKNQNRIRNRWELITCGLGGHVTYAPDDAALAARLRASTGLGE
                     VWRCLRCGDFALGGPQGRGAPEDAPLIMRGKALRQAIIIRALGVERLVRALVLALAAW
                     AVWEFRGARGAIQATLDRDLPVLRAAGFKVDQMTVIHALEKALAAKPSTLALITGMLA
                     AYAVLQAVEGVGLWLLKRWGEYFAVVATSIFLPLEVHDLAKGITTTRVVTFSINVAAV
                     VYLLISKRLFGVRGGRKAYDVERRGEQLLDLERAAMLT"
     misc_feature    98732..99193
                     /locus_tag="Rv0090"
                     /note="Uncharacterized membrane protein, DUF2068 family
                     [Function unknown]; Region: COG3305"
                     /db_xref="CDD:225842"
     gene            99684..100451
                     /gene="mtn"
                     /locus_tag="Rv0091"
                     /gene_synonym="pfs"
                     /db_xref="GeneID:886953"
     CDS             99684..100451
                     /gene="mtn"
                     /locus_tag="Rv0091"
                     /gene_synonym="pfs"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/S-adenosylhomocysteine
                     nucleosidase"
                     /protein_id="NP_214605.1"
                     /db_xref="GeneID:886953"
                     /translation="MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHR
                     VVLAAAGMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDF
                     GLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGR
                     QPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRAL
                     SDLAGADSGVDFNRFVGEVAASSARVLLRLLPVLTAC"
     misc_feature    99693..100400
                     /gene="mtn"
                     /locus_tag="Rv0091"
                     /gene_synonym="pfs"
                     /note="Phosphorylase superfamily; Region: PNP_UDP_1;
                     cl00303"
                     /db_xref="CDD:320888"
     gene            100583..102868
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /db_xref="GeneID:886946"
     CDS             100583..102868
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /inference="protein motif:PROSITE:PS00154"
                     /inference="protein motif:PROSITE:PS01047"
                     /note="Belongs to the cation transport ATPases family
                     (E1-E2 ATPases), subfamily IB."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter ATPase A"
                     /protein_id="NP_214606.1"
                     /db_xref="GeneID:886946"
                     /translation="MTTAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRA
                     AVNFGTRVATIDTSEAVDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRL
                     AIAAVLFVPVADLSVMFGVVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHH
                     AASMETLISVGITAATIWSLYTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVL
                     VGRYFEARAKSQAGSALRALAALSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQI
                     VAADGLAVDGSAAVDMSAMTGEAKPTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQF
                     AGMVRLVEQAQAQKADAQRLADRISSVFVPAVLVIAALTAAGWLIAGGQPDRAVSAAL
                     AVLVIACPCALGLATPTAMMVASGRGAQLGIFLKGYKSLEATRAVDTVVFDKTGTLTT
                     GRLQVSAVTAAPGWEADQVLALAATVEAASEHSVALAIAAATTRRDAVTDFRAIPGRG
                     VSGTVSGRAVRVGKPSWIGSSSCHPNMRAARRHAESLGETAVFVEVDGEPCGVIAVAD
                     AVKDSARDAVAALADRGLRTMLLTGDNPESAAAVATRVGIDEVIADILPEGKVDVIEQ
                     LRDRGHVVAMVGDGINDGPALARADLGMAIGRGTDVAIGAADIILVRDHLDVVPLALD
                     LARATMRTVKLNMVWAFGYNIAAIPVAAAGLLNPLVAGAAMAFSSFFVVSNSLRLRKF
                     GRYPLGCGTVGGPQMTAPSSA"
     misc_feature    100631..100813
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(100649..100657,100664..100666)
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    100883..102799
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(101777..101779,101783..101785,102683..102685)
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    101777..101785
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="HM-ATPase signature motif; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(101909..101917,102092..102094,102140..102148,
                     102230..102232,102350..102358,102416..102418,
                     102425..102427,102434..102436,102491..102493,
                     102500..102502)
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
     misc_feature    101909..101929
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="P-type ATPase signature motif; other site"
                     /db_xref="CDD:319783"
     misc_feature    101909..101911
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:319783"
     misc_feature    order(102686..102688,102749..102751,102761..102763)
                     /gene="ctpA"
                     /locus_tag="Rv0092"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     gene            complement(102815..103663)
                     /locus_tag="Rv0093c"
                     /db_xref="GeneID:886945"
     CDS             complement(102815..103663)
                     /locus_tag="Rv0093c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214607.1"
                     /db_xref="GeneID:886945"
                     /translation="MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATI
                     DGMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAES
                     RPVVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPT
                     GAGTHLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAV
                     STTRILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWP
                     TDGSAA"
     misc_feature    complement(102818..103528)
                     /locus_tag="Rv0093c"
                     /note="Predicted anti-sigma-YlaC factor YlaD, contains
                     Zn-finger domain [Signal transduction mechanisms]; Region:
                     YlaC; COG5660"
                     /db_xref="CDD:227947"
     gene            complement(103710..104663)
                     /locus_tag="Rv0094c"
                     /db_xref="GeneID:886943"
     CDS             complement(103710..104663)
                     /locus_tag="Rv0094c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214608.1"
                     /db_xref="GeneID:886943"
                     /translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTE
                     RARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTP
                     DAAAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGK
                     GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIM
                     LFANDRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHN
                     NTHGHTEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD"
     misc_feature    complement(103995..>104663)
                     /locus_tag="Rv0094c"
                     /note="Domain of unknown function (DUF222); Region:
                     DUF222; pfam02720"
                     /db_xref="CDD:308380"
     misc_feature    complement(103860..104021)
                     /locus_tag="Rv0094c"
                     /note="HNH nucleases; HNH endonuclease signature which is
                     found in viral, prokaryotic, and eukaryotic proteins. The
                     alignment includes members of the large group of homing
                     endonucleases, yeast intron 1 protein, MutS, as well as
                     bacterial colicins, pyocins, and...; Region: HNHc;
                     cd00085"
                     /db_xref="CDD:238038"
     misc_feature    complement(order(103869..103871,103878..103883,
                     103893..103898,103929..103931,103935..103943,
                     103947..103949))
                     /locus_tag="Rv0094c"
                     /note="active site"
                     /db_xref="CDD:238038"
     repeat_region   complement(103713..105215)
                     /note="REP-2, len: 1503 nt. REP251, member of REP13E12
                     family."
     gene            complement(104805..105215)
                     /locus_tag="Rv0095c"
                     /db_xref="GeneID:886940"
     CDS             complement(104805..105215)
                     /locus_tag="Rv0095c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214609.1"
                     /db_xref="GeneID:886940"
                     /translation="MRYLPVSTRRIWVNPLCHFSFTVISGALFVSARRYDSNMLANSR
                     EELVEVFDALDADLDRLDEVSFEVLSTPERLRSLERLECLARRLPAAQHTLINQLDTQ
                     ASEEELGGTLCCALANRLRITKPEAGRRSAEAKP"
     misc_feature    complement(<104811..104993)
                     /locus_tag="Rv0095c"
                     /note="Domain of unknown function (DUF222); Region:
                     DUF222; pfam02720"
                     /db_xref="CDD:308380"
     gene            105324..106715
                     /gene="PPE1"
                     /locus_tag="Rv0096"
                     /db_xref="GeneID:886938"
     CDS             105324..106715
                     /gene="PPE1"
                     /locus_tag="Rv0096"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE1"
                     /protein_id="YP_177690.1"
                     /db_xref="GeneID:886938"
                     /translation="MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQ
                     LLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMP
                     TPAELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATV
                     AVPSTQPAPPIRAPGGDAADTRLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSP
                     AVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLL
                     PIAAALGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISY
                     AVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRD
                     EFLDATATVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTV
                     PLLPTTWTTDAEQ"
     misc_feature    105327..105767
                     /gene="PPE1"
                     /locus_tag="Rv0096"
                     /note="PPE family; Region: PPE; pfam00823"
                     /db_xref="CDD:307116"
     gene            106734..107603
                     /locus_tag="Rv0097"
                     /db_xref="GeneID:886942"
     CDS             106734..107603
                     /locus_tag="Rv0097"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:11271494]"
                     /inference="protein motif:PROSITE:PS00077"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214611.1"
                     /db_xref="GeneID:886942"
                     /translation="MTLKVKGEGLGAQVTGVDPKNLDDITTDEIRDIVYTNKLVVLKD
                     VHPSPREFIKLGRIIGQIVPYYEPMYHHEDHPEIFVSSTEEGQGVPKTGAFWHIDYMF
                     MPEPFAFSMVLPLAVPGHDRGTYFIDLARVWQSLPAAKRDPARGTVSTHDPRRHIKIR
                     PSDVYRPIGEVWDEINRTTPPIKWPTVIRHPKTGQEILYICATGTTKIEDKDGNPVDP
                     EVLQELMAATGQLDPEYQSPFIHTQHYQVGDIILWDNRVLMHRAKHGSAAGTLTTYRL
                     TMLDGLKTPGYAA"
     misc_feature    106734..107597
                     /locus_tag="Rv0097"
                     /note="Taurine dioxygenase, alpha-ketoglutarate-dependent
                     [Secondary metabolites biosynthesis, transport and
                     catabolism]; Region: TauD; COG2175"
                     /db_xref="CDD:225086"
     gene            107600..108151
                     /gene="fcoT"
                     /locus_tag="Rv0098"
                     /db_xref="GeneID:886935"
     CDS             107600..108151
                     /gene="fcoT"
                     /locus_tag="Rv0098"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:17524985]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="type III, conserved in mycobacterial strains (See
                     Marmiesse et al., 2004 PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="fatty acyl CoA thioesterase FcoT"
                     /protein_id="NP_214612.1"
                     /db_xref="GeneID:886935"
                     /translation="MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDA
                     QYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVL
                     RGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCV
                     IEFWDENGGAASGEIELAALNIP"
     misc_feature    107681..108133
                     /gene="fcoT"
                     /locus_tag="Rv0098"
                     /note="FcoT-like thioesterase domain; Region: FcoT;
                     pfam10862"
                     /db_xref="CDD:313940"
     gene            108156..109778
                     /gene="fadD10"
                     /locus_tag="Rv0099"
                     /db_xref="GeneID:886933"
     CDS             108156..109778
                     /gene="fadD10"
                     /locus_tag="Rv0099"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00455"
                     /codon_start=1
                     /transl_table=11
                     /product="fatty-acid--CoA ligase FadD10"
                     /protein_id="NP_214613.1"
                     /db_xref="GeneID:886933"
                     /translation="MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRY
                     RELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPI
                     AAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASL
                     AGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTY
                     SPLPATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVS
                     ELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDG
                     SIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNP
                     ERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGV
                     REAACYEIPDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVI
                     VTDIPRTQSGKVMRASLAAAATADKARVVVRG"
     misc_feature    108156..109775
                     /gene="fadD10"
                     /locus_tag="Rv0099"
                     /note="acyl-CoA synthetase; Validated; Region: PRK05857"
                     /db_xref="CDD:180293"
     gene            109783..110019
                     /locus_tag="Rv0100"
                     /db_xref="GeneID:886931"
     CDS             109783..110019
                     /locus_tag="Rv0100"
                     /note="conserved in mycobacterial strains (See Marmiesse
                     et al., 2004 PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214614.1"
                     /db_xref="GeneID:886931"
                     /translation="MRDRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQ
                     LGVNRQSELPSRLAANPSIAGWLRELEAVCTEFG"
     misc_feature    109789..109992
                     /locus_tag="Rv0100"
                     /note="Phosphopantetheine attachment site; Region:
                     PP-binding; pfam00550"
                     /db_xref="CDD:306928"
     gene            110001..117539
                     /gene="nrp"
                     /locus_tag="Rv0101"
                     /db_xref="GeneID:886951"
     CDS             110001..117539
                     /gene="nrp"
                     /locus_tag="Rv0101"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00012"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00455"
                     /note="Belongs to the ATP-dependent AMP-binding enzyme
                     family."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide synthetase Nrp"
                     /protein_id="NP_214615.1"
                     /db_xref="GeneID:886951"
                     /translation="MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRLELARFLA
                     ALHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADEHLQSTWCSGILGKPL
                     VRHTVHTDPNGYVTGLDVHTHHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAK
                     LREAHRRETAKVEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATI
                     CGNAFDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVA
                     TCLVNSVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVE
                     ALTLNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWNRADLP
                     ACKTHPKVAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAW
                     FLDSARGVHQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGC
                     GYSVCDTADEISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTH
                     DALLATKTAYIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTS
                     DISVEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADGD
                     AIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIV
                     CDQTTMDGALLRLGRPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSR
                     RRAFATGDRVTVDAEGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELH
                     SGSLGVWFKSQRTREGEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDN
                     LPRLPQWSAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILPE
                     TRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQR
                     RLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPR
                     QLVIEARRADLGCDIVDATAWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEH
                     VLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGD
                     LDDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRGASLVVDWPASVQQQVR
                     RIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLVL
                     RVNLAGDPSFAELLGQVRARSLAAYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQ
                     DNPVGQLNLGDLQATPMPIDTRTARMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEA
                     QAIDVLIERLRKVLVAVAAAPERTVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSI
                     PQMLAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERC
                     APAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAGHDLPI
                     IDVVDALAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHRNVTRLFASLPARLS
                     AAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEHVSVLTQ
                     TPAAVAMLPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTICAAISAPL
                     RPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRAGLTASRF
                     VACPFGGSGARMYRTGDLVCWRADGQLEFLGRTDDQVKIRGYRIELGEVATALAELAG
                     VGQAVVIAREDRPGDKRLVGYATEIAPGAVDPAGLRAQLAQRLPGYLVPAAVVVIDAL
                     PLTVNGKLDHRALPAPEYGDTNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELG
                     GDSLAAMRVIAAINTTLNADLPVRALLHASSTRGLSQLLGRDARPTSDPRLVSVHGDN
                     PTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLD
                     VDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGDKSEPDLGL
                     DQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGTAELIRIALTTKLKPFTYVST
                     ADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSKWAGEVLLREANDLCALPVA
                     VFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLP
                     VTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGLDEYVDWLIEAGYPIRRIDDF
                     AEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTRGCSAPTDRFRAAVRAA
                     KVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL"
     misc_feature    110838..112538
                     /gene="nrp"
                     /locus_tag="Rv0101"
                     /note="Non-ribosomal peptide synthetase component F
                     [Secondary metabolites biosynthesis, transport and
                     catabolism]; Region: EntF; COG1020"
                     /db_xref="CDD:223951"
     misc_feature    111723..>116081
                     /gene="nrp"
                     /locus_tag="Rv0101"
                     /note="AMP-binding enzyme; Region: AMP-binding; cl27678"
                     /db_xref="CDD:332499"
     misc_feature    116322..117536
                     /gene="nrp"
                     /locus_tag="Rv0101"
                     /note="Thioester reductase domain of alpha aminoadipate
                     reductase Lys2 and NRPSs [Secondary metabolites
                     biosynthesis, transport and catabolism]; Region: Lys2b;
                     COG3320"
                     /db_xref="CDD:225857"
     gene            117714..119699
                     /locus_tag="Rv0102"
                     /db_xref="GeneID:886926"
     CDS             117714..119699
                     /locus_tag="Rv0102"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00343"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane protein"
                     /protein_id="NP_214616.1"
                     /db_xref="GeneID:886926"
                     /translation="MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLV
                     SGARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAA
                     AFRIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWI
                     VAAICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVF
                     AVAFATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFA
                     RLGLLAGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAP
                     RFLTHAFTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRR
                     GNSWPVGRLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGP
                     VTLALRVLPVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLF
                     DTFVRYHWGHEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFG
                     IALMTMSSTVGATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWAR
                     QDRRVASREDRHADSDYADDELEAYNAMLRELSRMRR"
     misc_feature    118779..119696
                     /locus_tag="Rv0102"
                     /note="Cytochrome c oxidase assembly factor CtaG [Energy
                     production and conversion, Posttranslational modification,
                     protein turnover, chaperones]; Region: CtaG; COG3336"
                     /db_xref="CDD:225873"
     gene            complement(119915..122173)
                     /gene="ctpB"
                     /locus_tag="Rv0103c"
                     /db_xref="GeneID:886928"
     CDS             complement(119915..122173)
                     /gene="ctpB"
                     /locus_tag="Rv0103c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00154"
                     /inference="protein motif:PROSITE:PS01047"
                     /note="Belongs to the cation transport ATPases family
                     (E1-E2 ATPases), subfamily IB."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-transporter P-type ATPase B"
                     /protein_id="NP_214617.1"
                     /db_xref="GeneID:886928"
                     /translation="MAAPVVGDADLQSVRRIRLDVLGMSCAACASRVETKLNKIPGVR
                     ASVNFATRVATIDAVGMAADELCGVVEKAGYHAAPHTETTVLDKRTKDPDGAHARRLL
                     RRLLVAAVLFVPLADLSTLFAIVPSARVPGWGYILTALAAPVVTWAAWPFHSVALRNA
                     RHRTTSMETLISVGIVAATAWSLSSVFGDQPPREGSGIWRAILNSDSIYLEVAAGVTV
                     FVLAGRYFEARAKSKAGSALRALAELGAKNVAVLLPDGAELVIPASELKKRQRFVTRP
                     GETIAADGVVVDGSAAIDMSAMTGEAKPVRAYPAASVVGGTVVMDGRLVIEATAVGAD
                     TQFAAMVRLVEQAQTQKARAQRLADHIAGVFVPVVFVIAGLAGAAWLVSGAGADRAFS
                     VTLGVLVIACPCALGLATPTAMMVASGRGAQLGIFIKGYRALETIRSIDTVVFDKTGT
                     LTVGQLAVSTVTMAGSGTSERDREEVLGLAAAVESASEHAMAAAIVAASPDPGPVNGF
                     VAVAGCGVSGEVGGHHVEVGKPSWITRTTPCHDAALVSARLDGESRGETVVFVSVDGV
                     VRAALTIADTLKDSAAAAVAALRSRGLRTILLTGDNRAAADAVAAQVGIDSAVADMLP
                     EGKVDVIQRLREEGHTVAMVGDGINDGPALVGADLGLAIGRGTDVALGAADIILVRDD
                     LNTVPQALDLARATMRTIRMNMIWAFGYNVAAIPIAAAGLLNPLIAGAAMAFSSFFVV
                     SNSLRLRNFGAQ"
     misc_feature    complement(119927..122131)
                     /gene="ctpB"
                     /locus_tag="Rv0103c"
                     /note="Cation transport ATPase [Inorganic ion transport
                     and metabolism]; Region: ZntA; COG2217"
                     /db_xref="CDD:225127"
     gene            122317..123831
                     /locus_tag="Rv0104"
                     /db_xref="GeneID:886923"
     CDS             122317..123831
                     /locus_tag="Rv0104"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214618.1"
                     /db_xref="GeneID:886923"
                     /translation="MTPVTTFPLVDAILAGRDRNLDGVILIAAQHLLQTTHAMLRSLF
                     RVGLDPRNVAVIGKCYSTHPGVVDAMRADGIYVDDCSDAYAPHESFDTQYTRHVERFF
                     AESWARLTAGRTARVVLLDDGGSLLAVAGAMLDASADVIGIEQTSAGYAKIVGCALGF
                     PVINIARSSAKLLYESPIIAARVTQTAFERTAGIDSSAAILITGAGAIGTALADVLRP
                     LHDRVDVYDTRSGCMTPIDLPNAIGGYDVIIGATGATSVPASMHELLRPGVLLMSASS
                     SDREFDAVALRRRTTPNPDCHADLRVADGSVDATLLNSGFPVNFDGSPMCGDASMALT
                     MALLAAAVLYASVAVADEMSSDHPHLGLIDQGDIVASFLNIDVPLQALSRLPLLSIDG
                     YRRLQVRSGYTLFRQGERADHFFVIESGELEALVDGKVILRLGAGDHFGEACLLGGMR
                     RIATVRACEPSVLWELDGKAFGDALHGDAAMREIAYGVARTRLMHAGASESLMV"
     misc_feature    122362..>123180
                     /locus_tag="Rv0104"
                     /note="S-adenosylhomocysteine hydrolase [Coenzyme
                     transport and metabolism]; Region: SAM1; cl28379"
                     /db_xref="CDD:333199"
     misc_feature    122896..>123141
                     /locus_tag="Rv0104"
                     /note="NAD-dependent glycerol-3-phosphate dehydrogenase
                     C-terminus; Region: NAD_Gly3P_dh_C; cl26891"
                     /db_xref="CDD:331712"
     misc_feature    123448..123762
                     /locus_tag="Rv0104"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(123637..123642,123667..123675)
                     /locus_tag="Rv0104"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(123733..123741,123751..123759)
                     /locus_tag="Rv0104"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     gene            complement(123980..124264)
                     /gene="rpmB1"
                     /locus_tag="Rv0105c"
                     /db_xref="GeneID:886920"
     CDS             complement(123980..124264)
                     /gene="rpmB1"
                     /locus_tag="Rv0105c"
                     /note="Belongs to the L28P family of ribosomal proteins."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="YP_177691.1"
                     /db_xref="GeneID:886920"
                     /translation="MSARCQITGRTVGFGKAVSHSHRRTRRRWPPNIQLKAYYLPSED
                     RRIKVRVSAQGIKVIDRDGHRGRRRAARAGSAPAHFARQAGSSLRTAAIL"
     misc_feature    complement(<124088..124264)
                     /gene="rpmB1"
                     /locus_tag="Rv0105c"
                     /note="50S ribosomal protein L28; Reviewed; Region: rpmB;
                     PRK00359"
                     /db_xref="CDD:234736"
     gene            124374..125570
                     /locus_tag="Rv0106"
                     /db_xref="GeneID:886919"
     CDS             124374..125570
                     /locus_tag="Rv0106"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214620.1"
                     /db_xref="GeneID:886919"
                     /translation="MRTPVILVAGQDHTDEVTGALLRRTGTVVVEHRFDGHVVRRMTA
                     TLSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPWLEPQPI
                     CWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLGEDELPDGRTVAQVT
                     VGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGGVDRVELALAHLDDNSRRGRTDTP
                     HTPLLAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLWLANRPD
                     QVMWLESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVL
                     VCGADPTDIVNALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHR
                     NSGESR"
     misc_feature    124380..125429
                     /locus_tag="Rv0106"
                     /note="Cobalamin synthesis protein cobW C-terminal domain;
                     Region: CobW_C; cl26870"
                     /db_xref="CDD:331691"
     gene            complement(125643..130541)
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /db_xref="GeneID:886915"
     CDS             complement(125643..130541)
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00154"
                     /note="Belongs to the cation transport ATPases family
                     (E1-E2 ATPases)."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-transporter ATPase I"
                     /protein_id="NP_214621.1"
                     /db_xref="GeneID:886915"
                     /translation="MKIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLE
                     LTGPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPFPRWHEH
                     AAMVEEPVRRIPGVAEAHVEGSLGRLVVELEPDADSDIAVDEVRDVVSAVAADIFLAG
                     SVSSPNSAPFADPGNPLAILVPLTAAAMDLVAMGATVTGWVARLPAAPQTTRALAALI
                     NHQPRMVSLMESRLGRVGTDIALAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHR
                     RVWRDREPALASPRRPQAPVVPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAA
                     IDTAKGSRAGPVEQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQA
                     FAAVLGRGLANTGQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEPGWDDD
                     RVYEVADALLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQGLEHADLVVDGQCV
                     GSVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVGSTHPPGTPLLKLVRE
                     LRADRGPVLLITAVHRDFASTDTLAALAIADVGVALDDPRGATPWTADLITGTDLAAA
                     VRILSALPVARAASESAVHLAQGGTTLAGLLLVTGEQDKTTNPASFRRWLNPVNAAAA
                     TALVSGMWSAAKVLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRI
                     LDDLSYEPVMAPLRGPARTLAQLAVATRHELADPLTPILAVGAAASAIVGSNIDALLV
                     AGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTRRRLEAARHATRTA
                     TVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLEVDESFLTGESLPVDKQVDPVAVND
                     PDRASMLFEGSTIVAGHARAIVVATGVGTAAHRAISAVADVETAAGVQARLRELTSKV
                     LPMTLAGGAAVTALALLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTA
                     RGALVRSPRTIEALGRVDTICFDKTGTLTENRLRVVCALPSSTAAERDPLPQTTDAPS
                     AEVLRAAARASTQPHNGEGHAHATDEAILAAASALAGSLSSQGDSEWVVLAEVPFESS
                     RGYAAAIGRVGTDGIPMLMLKGAPETILPRCRLADPGVDHEHAESVVRHLAEQGLRVL
                     AVAQRTWDNGTTHDDETDADAVDAVAHDLELIGYVGLADTARSSSRPLIEALLDAERN
                     VVLITGDHPITARAIARQLGLPADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQ
                     KVQIVAALQRCGRVTAMVGDGANDAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDL
                     GVLLDALVEGRSMWAGVRDAVTILVGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNL
                     LTDMFPALAVAVTSQFAEPDDAEYPTDDAAERAQREHRRAVLIGPTPSLDAPLLRQIV
                     NRGVVTAAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLTRRHSPLVIATAL
                     GSAGVLVGIIQTPVISHFSGVPRWDRSPGRASSAPRQEPPQSQRWHRSGWQAQSVSCN
                     LMNALTTRKTLTRVDRTYRRPR"
     misc_feature    complement(126195..128318)
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /note="uncharacterized subfamily of P-type ATPase
                     transporters; Region: P-type_ATPase; cd07539"
                     /db_xref="CDD:319840"
     misc_feature    complement(order(126513..126515,126522..126524,
                     126579..126581,126588..126590,126597..126599,
                     126735..126743,126930..126932,127035..127043,
                     127113..127115,127377..127385))
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319840"
     misc_feature    complement(127365..127385)
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /note="P-type ATPase signature motif; other site"
                     /db_xref="CDD:319840"
     misc_feature    complement(127383..127385)
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /note="phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:319840"
     misc_feature    complement(order(126225..126230,126237..126239,
                     126315..126320,126324..126329,126339..126341))
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /note="putative cation binding site [ion binding]; other
                     site"
                     /db_xref="CDD:319840"
     misc_feature    complement(125832..126254)
                     /gene="ctpI"
                     /locus_tag="Rv0107c"
                     /note="Cation transporting ATPase, C-terminus; Region:
                     Cation_ATPase_C; pfam00689"
                     /db_xref="CDD:307026"
     gene            complement(130895..131104)
                     /locus_tag="Rv0108c"
                     /db_xref="GeneID:886918"
     CDS             complement(130895..131104)
                     /locus_tag="Rv0108c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214622.1"
                     /db_xref="GeneID:886918"
                     /translation="MVPVETLHSGDPITDVNGGGQRYIVLESKTVGDSCVVLELESRV
                     NHQLQVIEKSFPAGYHVGRAHHRIL"
     gene            131382..132872
                     /gene="PE_PGRS1"
                     /locus_tag="Rv0109"
                     /db_xref="GeneID:886912"
     CDS             131382..132872
                     /gene="PE_PGRS1"
                     /locus_tag="Rv0109"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="Member of the M. tuberculosis PE family, PGRS
                     subfamily of gly-rich proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="PE-PGRS family protein PE_PGRS1"
                     /protein_id="YP_177692.1"
                     /db_xref="GeneID:886912"
                     /translation="MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGA
                     DEVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQ
                     TVQQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQA
                     GGNGGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPG
                     GAGGNAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADG
                     GLGGGGGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGG
                     LAGIGGNAGFVRNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGN
                     GGMGGNAVGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAA
                     SAGGNGGNARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS"
     misc_feature    131382..131648
                     /gene="PE_PGRS1"
                     /locus_tag="Rv0109"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:279302"
     gene            133020..133769
                     /locus_tag="Rv0110"
                     /db_xref="GeneID:886917"
     CDS             133020..133769
                     /locus_tag="Rv0110"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane protein"
                     /protein_id="NP_214624.1"
                     /db_xref="GeneID:886917"
                     /translation="MRVGPVGHQCAECVREGARAVRQPRTPFGGRQRSATPVVTYTLI
                     SLNALVFVMQVTVMGLERQLALWPPAVASGQTYRLVTSAFLHYGAMHLLLNMWALYVV
                     GPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNTATAGASGAVFGLFGATFMVARR
                     LHLDVRWVVALIVINLAFTFLAPAISWQGHVGGLVTGALVAATYVYAPRERRNLIQAT
                     VTITVLVAFVVLIGWRTVDLLALFGGRLNLS"
     misc_feature    133227..133646
                     /locus_tag="Rv0110"
                     /note="Rhomboid family; Region: Rhomboid; pfam01694"
                     /db_xref="CDD:307698"
     gene            133950..136007
                     /locus_tag="Rv0111"
                     /db_xref="GeneID:886909"
     CDS             133950..136007
                     /locus_tag="Rv0111"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase"
                     /protein_id="NP_214625.1"
                     /db_xref="GeneID:886909"
                     /translation="MPARSVPRPRWVAPVRRVGRLAVWDRPERRSGIPALDGLRAIAV
                     ALVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFWIRRARRL
                     LPALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFVAQNTDYFTQGAPPSP
                     LQHTWSLGVEEQYYVVWPLLLIGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMA
                     SATAAVAFTSAATRDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGR
                     RIARLLPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARI
                     LAWRPLVWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLI
                     EQPIRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAVAAVSP
                     SPPEASQPAPGPRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFRFIDHTVIGCSLVRGT
                     PYRYIGQTLEQRAECDGWPARWSAQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDP
                     TFDAYLNAELQRALSIVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAML
                     HNAISQHSNVGMIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVR
                     VAS"
     misc_feature    134037..135167
                     /locus_tag="Rv0111"
                     /note="Peptidoglycan/LPS O-acetylase OafA/YrhL, contains
                     acyltransferase and SGNH-hydrolase domains [Cell
                     wall/membrane/envelope biogenesis]; Region: OafA; COG1835"
                     /db_xref="CDD:224748"
     misc_feature    <135528..135983
                     /locus_tag="Rv0111"
                     /note="SGNH_hydrolase, or GDSL_hydrolase, is a diverse
                     family of lipases and esterases. The tertiary fold of the
                     enzyme is substantially different from that of the
                     alpha/beta hydrolase family and unique among all known
                     hydrolases; its active site closely...; Region:
                     SGNH_hydrolase; cl01053"
                     /db_xref="CDD:321319"
     gene            136289..137245
                     /gene="gca"
                     /locus_tag="Rv0112"
                     /db_xref="GeneID:886907"
     CDS             136289..137245
                     /gene="gca"
                     /locus_tag="Rv0112"
                     /inference="protein motif:PROSITE:PS00061"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="NP_214626.1"
                     /db_xref="GeneID:886907"
                     /translation="MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFN
                     GAEVDITDWCSVYDSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEAL
                     RRVRPHAKIIVAGSSAEYGFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSY
                     GMHTVVARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRDL
                     NRALMLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEK
                     IIYGDCSKLAAITGWQQEICLTQTIADMFDYWRSKSESALMV"
     misc_feature    136292..137215
                     /gene="gca"
                     /locus_tag="Rv0112"
                     /note="Short-chain dehydrogenases/reductases (SDR);
                     Region: SDR; cl25409"
                     /db_xref="CDD:330230"
     misc_feature    order(136307..136309,136313..136318,136322..136324,
                     136379..136387,136499..136507,136628..136636,
                     136712..136714,136724..136726,136793..136804)
                     /gene="gca"
                     /locus_tag="Rv0112"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:187535"
     misc_feature    order(136559..136561,136634..136636,136712..136714,
                     136724..136726)
                     /gene="gca"
                     /locus_tag="Rv0112"
                     /note="active site"
                     /db_xref="CDD:187535"
     gene            137319..137909
                     /gene="gmhA"
                     /locus_tag="Rv0113"
                     /gene_synonym="lpcA"
                     /db_xref="GeneID:886905"
     CDS             137319..137909
                     /gene="gmhA"
                     /locus_tag="Rv0113"
                     /gene_synonym="lpcA"
                     /note="sedoheptulose-7-phosphate isomerase GmhA. Belongs
                     to the sis family, LPCA subfamily. This region is a
                     possible MT-complex-specific genomic island (See Becq et
                     al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoheptose isomerase"
                     /protein_id="NP_214627.1"
                     /db_xref="GeneID:886905"
                     /translation="MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRA
                     GARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTV
                     FARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADF
                     LINVPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ"
     misc_feature    137319..137906
                     /gene="gmhA"
                     /locus_tag="Rv0113"
                     /gene_synonym="lpcA"
                     /note="SIS domain. SIS (Sugar ISomerase) domains are found
                     in many phosphosugar isomerases and phosphosugar binding
                     proteins. SIS domains are also found in proteins that
                     regulate the expression of genes involved in synthesis of
                     phosphosugars; Region: SIS; cl00389"
                     /db_xref="CDD:320949"
     misc_feature    order(137358..137360,137370..137372,137412..137414,
                     137421..137423,137481..137483,137499..137504,
                     137835..137840,137850..137852,137859..137861,
                     137871..137873,137883..137885)
                     /gene="gmhA"
                     /locus_tag="Rv0113"
                     /gene_synonym="lpcA"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:240139"
     misc_feature    order(137475..137483,137679..137687,137694..137696,
                     137823..137825,137835..137837)
                     /gene="gmhA"
                     /locus_tag="Rv0113"
                     /gene_synonym="lpcA"
                     /note="active site"
                     /db_xref="CDD:240139"
     gene            137941..138513
                     /gene="gmhB"
                     /locus_tag="Rv0114"
                     /db_xref="GeneID:886903"
     CDS             137941..138513
                     /gene="gmhB"
                     /locus_tag="Rv0114"
                     /note="D-alpha,beta-D-heptose-1,7-biphosphate phosphatase
                     GmhB. This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="D-glycero-alpha-D-manno-heptose-1,7-bisphosphate
                     7-phosphatase"
                     /protein_id="NP_214628.1"
                     /db_xref="GeneID:886903"
                     /translation="MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARA
                     LKKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHR
                     SQRCGCRKPRPGLVLDWLGRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIG
                     GASSGGVADASFDSLWEFAVAVGHARGERG"
     misc_feature    137968..138381
                     /gene="gmhB"
                     /locus_tag="Rv0114"
                     /note="histidinol-phosphate phosphatase family domain;
                     Region: Histidinol-ppas; TIGR01656"
                     /db_xref="CDD:273737"
     gene            138513..139673
                     /gene="hddA"
                     /locus_tag="Rv0115"
                     /db_xref="GeneID:886902"
     CDS             138513..139673
                     /gene="hddA"
                     /locus_tag="Rv0115"
                     /inference="protein motif:PROSITE:PS00435"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alpha-D-heptose-7-phosphate kinase HddA"
                     /protein_id="NP_214629.1"
                     /db_xref="GeneID:886902"
                     /translation="MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAF
                     AERGTGDEIAFRSPDRDRAGQASIDDLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQL
                     ATQVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQ
                     DHYAAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQ
                     QRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNP
                     AIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFT
                     KGGAVTWHIPESTAPVRRGVADAVASALGNAGILLCAGCVLATSHSTWRVPV"
     misc_feature    138513..139544
                     /gene="hddA"
                     /locus_tag="Rv0115"
                     /note="Predicted kinase related to galactokinase and
                     mevalonate kinase [General function prediction only];
                     Region: COG2605"
                     /db_xref="CDD:225325"
     gene            139956..140144
                     /locus_tag="Rv0115a"
                     /db_xref="GeneID:19394668"
     CDS             139956..140144
                     /locus_tag="Rv0115a"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_009030027.1"
                     /db_xref="GeneID:19394668"
                     /translation="MTTMIMTFVVPQRVTRATKGRARSLLRVSRRLTDTFRAPLAWTP
                     QERADRYVARMPIAVIAD"
     gene            complement(140267..141022)
                     /gene="ldtA"
                     /locus_tag="Rv0116c"
                     /db_xref="GeneID:886900"
     CDS             complement(140267..141022)
                     /gene="ldtA"
                     /locus_tag="Rv0116c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="L,D-transpeptidase LdtA"
                     /protein_id="NP_214630.1"
                     /db_xref="GeneID:886900"
                     /translation="MRRVVRYLSVVVAITLMLTAESVSIATAAVPPLQPIPGVASVSP
                     ANGAVVGVAHPVVVTFTTPVTDRRAVERSIRISTPHNTTGHFEWVASNVVRWVPHRYW
                     PPHTRVSVGVQELTEGFETGDALIGVASISAHTFTVSRNGEVLRTMPASLGKPSRPTP
                     IGSFHAMSKERTVVMDSRTIGIPLNSSDGYLLTAHYAVRVTWSGVYVHSAPWSVNSQG
                     YANVSHGCINLSPDNAAWYFDAVTVGDPIEVVG"
     misc_feature    complement(140270..140980)
                     /gene="ldtA"
                     /locus_tag="Rv0116c"
                     /note="Lipoprotein-anchoring transpeptidase ErfK/SrfK
                     [Cell wall/membrane/envelope biogenesis]; Region: ErfK;
                     COG1376"
                     /db_xref="CDD:224294"
     gene            141200..142144
                     /gene="oxyS"
                     /locus_tag="Rv0117"
                     /db_xref="GeneID:886914"
     CDS             141200..142144
                     /gene="oxyS"
                     /locus_tag="Rv0117"
                     /experiment="DESCRIPTION:Gene expression[PMID:1489419]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00044"
                     /note="LysR family, involved in the resistance to organic
                     hydroperoxides"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidative stress response regulatory protein
                     OxyS"
                     /protein_id="NP_214631.1"
                     /db_xref="GeneID:886914"
                     /translation="MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELN
                     VTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTAS
                     TTASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVP
                     LYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQVIDAAFADHAVSAIP
                     QVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALA
                     TNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR"
     misc_feature    141200..142093
                     /gene="oxyS"
                     /locus_tag="Rv0117"
                     /note="DNA-binding transcriptional regulator, LysR family
                     [Transcription]; Region: LysR; COG0583"
                     /db_xref="CDD:223656"
     gene            complement(142128..143876)
                     /gene="oxcA"
                     /locus_tag="Rv0118c"
                     /db_xref="GeneID:886898"
     CDS             complement(142128..143876)
                     /gene="oxcA"
                     /locus_tag="Rv0118c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxalyl-CoA decarboxylase OxcA"
                     /protein_id="NP_214632.1"
                     /db_xref="GeneID:886898"
                     /translation="MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLAR
                     AAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCF
                     PMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTAT
                     SGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQR
                     PLLVLSKGAAYAQADNVIREFVEHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARA
                     DVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSA
                     LLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRN
                     PDVYVVNEGANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAI
                     EGDSAFGFSGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWRHDPAPTVL
                     NAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVESGHLA
                     KLNTTSAATPAISGDG"
     misc_feature    complement(142146..143843)
                     /gene="oxcA"
                     /locus_tag="Rv0118c"
                     /note="putative oxalyl-CoA decarboxylase; Validated;
                     Region: PRK09259"
                     /db_xref="CDD:236433"
     gene            144049..145626
                     /gene="fadD7"
                     /locus_tag="Rv0119"
                     /db_xref="GeneID:886896"
     CDS             144049..145626
                     /gene="fadD7"
                     /locus_tag="Rv0119"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00455"
                     /codon_start=1
                     /transl_table=11
                     /product="fatty-acid--CoA ligase FadD7"
                     /protein_id="NP_214633.1"
                     /db_xref="GeneID:886896"
                     /translation="MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLV
                     DELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRS
                     QAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATS
                     TPEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLY
                     HGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERS
                     ATEPSGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMTEATHQVTTTQIEG
                     IDQTETPVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTIT
                     AANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEA
                     AVFGVPHQLYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTA
                     KGSLDRRAVAERFGHSV"
     misc_feature    144049..145623
                     /gene="fadD7"
                     /locus_tag="Rv0119"
                     /note="acyl-CoA synthetase; Validated; Region: PRK05852"
                     /db_xref="CDD:235625"
     gene            complement(145627..147771)
                     /gene="fusA2"
                     /locus_tag="Rv0120c"
                     /gene_synonym="fus2"
                     /db_xref="GeneID:886894"
     CDS             complement(145627..147771)
                     /gene="fusA2"
                     /locus_tag="Rv0120c"
                     /gene_synonym="fus2"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /note="Belongs to the GTP-binding elongation factor
                     family, EF-G/EF-2 subfamily."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="NP_214634.1"
                     /db_xref="GeneID:886894"
                     /translation="MADRVNASQGAAAAPTANGPGGVRNVVLVGPSGGGKTTLIEALL
                     VAAKVLSRPGSVTEGTTVCDFDEAEIRQQRSVGLAVASLAYDGIKVNLVDTPGYADFV
                     GELRAGLRAADCALFVIAANEGVDEPTKSLWQECSQVGMPRAVVITKLDHARANYREA
                     LTAAQDAFGDKVLPLYLPSGDGLIGLLSQALYEYADGKRTTRTPAESDTERIEEARGA
                     LIEGIIEESEDESLMERYLGGETIDESVLIQDLEKAVARGSFFPVIPVCSSTGVGTLE
                     LLEVATRGFPSPMEHPLPEVFTPQGVPHAELACDNDAPLLAEVVKTTSDPYVGRVSLV
                     RVFSGTIRPDTTVHVSGHFSSFFGGGTSNTHPDHDEDERIGVLSFPLGKQQRPAAAVV
                     AGDICAIGKLSRAETGDTLSDKAEPLVLKPWTMPEPLLPIAIAAHAKTDEDKLSVGLG
                     RLAAEDPTLRIEQNQETHQVVLWCMGEAHAGVVLDTLANRYGVSVDTIELRVPLRETF
                     AGNAKGHGRHIKQSGGHGQYGVCDIEVEPLPEGSGFEFLDKVVGGAVPRQFIPNVEKG
                     VRAQMDKGVHAGYPVVDIRVTLLDGKAHSVDSSDFAFQMAGALALREAAAATKVILLE
                     PIDEISVLVPDDFVGAVLGDLSSRRGRVLGTETAGHDRTVIKAEVPQVELTRYAIDLR
                     SLAHGAASFTRSFARYEPMPESAAARVKAGAG"
     misc_feature    complement(145639..147687)
                     /gene="fusA2"
                     /locus_tag="Rv0120c"
                     /gene_synonym="fus2"
                     /note="elongation factor G; Reviewed; Region: PRK12740"
                     /db_xref="CDD:237186"
     gene            complement(147908..148342)
                     /locus_tag="Rv0121c"
                     /db_xref="GeneID:886892"
     CDS             complement(147908..148342)
                     /locus_tag="Rv0121c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214635.1"
                     /db_xref="GeneID:886892"
                     /translation="MGEFDPKLRFAQSPVARLATSTPDGTPHLVPVVFALGARRPAEA
                     TGADVIYTAVDAKRKTTQRLRRLANLEHNPRASVLVDSYADDWTQLWWVRADGVAAIH
                     RDGEVMRAAYRLLRAKYAQYQSVPLNGPVIAIAVQRWASWHA"
     misc_feature    complement(147914..148339)
                     /locus_tag="Rv0121c"
                     /note="PPOX class probable F420-dependent enzyme, Rv0121
                     family; Region: Rv0121_F420; TIGR03668"
                     /db_xref="CDD:132707"
     gene            148491..148859
                     /locus_tag="Rv0122"
                     /db_xref="GeneID:886888"
     CDS             148491..148859
                     /locus_tag="Rv0122"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214636.1"
                     /db_xref="GeneID:886888"
                     /translation="MAGSVSAAAGIGWVGLNVTETNRDQCYRVERTTVDALTHPEYRV
                     HTRGVQRVRVTRNARKHRVSKHRIVAAMRHCGVPVIQEDGSLYYQGRDTSGRLTEVVA
                     VEADDGDLIITHAMPKEWKR"
     gene            148856..149224
                     /locus_tag="Rv0123"
                     /db_xref="GeneID:886887"
     CDS             148856..149224
                     /locus_tag="Rv0123"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214637.1"
                     /db_xref="GeneID:886887"
                     /translation="MTKKPRNPADYVIGDDVEVSDVDLKQEEVYVDGERLTDERVEQM
                     ASESLRLAREREANLIPGGKSLSGGSAHSPAVQVVVSKATHAKLKELARSRKMSVSKL
                     LRPVLDEFVQRETGRILPRR"
     gene            149533..150996
                     /gene="PE_PGRS2"
                     /locus_tag="Rv0124"
                     /db_xref="GeneID:886883"
     CDS             149533..150996
                     /gene="PE_PGRS2"
                     /locus_tag="Rv0124"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="Member of the Mycobacterium tuberculosis PE family,
                     PGRS subfamily of gly-rich proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="PE-PGRS family protein PE_PGRS2"
                     /protein_id="YP_177693.1"
                     /db_xref="GeneID:886883"
                     /translation="MSFVSVAPEIVVAAATDLAGIGSAISAANAAAAAPTTAVLAAGA
                     DEVSAAIAALFSGHAQAYQALSAQAAAFHQQFVQTLAGGAGAYAAAEAQVEQQLLAAI
                     NAPTQALLGRPLIGNGADGAPGTGQAGGAGGILYGNGGNGGSGAAGQAGGAGGPAGLI
                     GHGGSGGAGGSGAAGGAGGHGGWLWGNGGVGGSGGAGVGAGVAGGHGGAGGAAGLWGA
                     GGGGGNGGNGADANIVSGGDGGLGGAGGGGGWLYGDGGAGGHGGQGAIGLGGGAGGDG
                     GQGGAGRGLWGTGGAGGHGGQGGGTGGPPLPGQAGMGAAGGAGGLIGNGGAGGDGGVG
                     ASGGVAGVGGAGGNAMLIGHGGAGGAGGDSSFANGAAGGAGGAGGHLFGNGGSGGHGG
                     AVTAGNTGIGGAGGVGGDARLIGHGGAGGAGGDRAGALVGRDGGPGGNGGAGGQLYGN
                     GGDGAPGTGGTLQAAVSGLVTALFGAPGQPGDTGQPG"
     misc_feature    149533..149772
                     /gene="PE_PGRS2"
                     /locus_tag="Rv0124"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:307197"
     gene            151148..152215
                     /gene="pepA"
                     /locus_tag="Rv0125"
                     /gene_synonym="mtb32a"
                     /db_xref="GeneID:886924"
     CDS             151148..152215
                     /gene="pepA"
                     /locus_tag="Rv0125"
                     /gene_synonym="mtb32a"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00135"
                     /note="Belongs to the serine protease family."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease PepA"
                     /protein_id="NP_214639.1"
                     /db_xref="GeneID:886924"
                     /translation="MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFAD
                     FPALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATD
                     INAFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSG
                     GQGGTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQ
                     VVGMNTAASDNFQLSQGGQGFAIPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVD
                     NNGNGARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMADALNGHHPGDVISVT
                     WQTKSGGTRTGNVTLAEGPPA"
     misc_feature    151178..152212
                     /gene="pepA"
                     /locus_tag="Rv0125"
                     /gene_synonym="mtb32a"
                     /note="Periplasmic serine protease, S1-C subfamily,
                     contain C-terminal PDZ domain [Posttranslational
                     modification, protein turnover, chaperones]; Region: DegQ;
                     COG0265"
                     /db_xref="CDD:223343"
     gene            152324..154129
                     /gene="treS"
                     /locus_tag="Rv0126"
                     /db_xref="GeneID:886881"
     CDS             152324..154129
                     /gene="treS"
                     /locus_tag="Rv0126"
                     /experiment="DESCRIPTION:Protein
                     characterization[PMID:10658666]"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:18505459]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="trehalose synthase/amylase TreS"
                     /protein_id="NP_214640.1"
                     /db_xref="GeneID:886881"
                     /translation="MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWF
                     KHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYD
                     IRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPY
                     GDYYVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQE
                     AMIDVIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRV
                     LLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTP
                     PIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDND
                     RNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTAN
                     PGRLYLPPSQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGG
                     SNPSVLAYVRQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIG
                     QVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL"
     misc_feature    152450..154075
                     /gene="treS"
                     /locus_tag="Rv0126"
                     /note="Alpha amylase, catalytic domain; Region:
                     Alpha-amylase; cl25947"
                     /db_xref="CDD:330768"
     repeat_region   154073..154125
                     /gene="treS"
                     /locus_tag="Rv0126"
                     /note="53 bp Mycobacterial Interspersed Repetitive
                     Unit,Class III (see Supply et al., 1997)"
     repeat_region   154126..154178
                     /note="53 bp Mycobacterial Interspersed Repetitive
                     Unit,Class II"
     repeat_region   154179..154231
                     /note="53 bp Mycobacterial Interspersed Repetitive
                     Unit,Class II"
     gene            154232..155599
                     /gene="mak"
                     /locus_tag="Rv0127"
                     /db_xref="GeneID:886880"
     CDS             154232..155599
                     /gene="mak"
                     /locus_tag="Rv0127"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="maltokinase"
                     /protein_id="NP_214641.1"
                     /db_xref="GeneID:886880"
                     /translation="MTRSDTLATKLPWSDWLSRQRWYAGRNRELATVKPGVVVALRHN
                     LDLVLVDVTYTDGATERYQVLVGWDFEPASEYGTKAAIGVADDRTGFDALYDVAGPQF
                     LLSLIVSSAVCGTSTGEVTFTREPDVELPFAAQPRVCDAEQSNTSVIFDRRAILKVFR
                     RVSSGINPDIELNRVLTRAGNPHVARLLGAYQFGRPNRSPTDALAYALGMVTEYEANA
                     AEGWAMATASVRDLFAEGDLYAHEVGGDFAGESYRLGEAVASVHATLADSLGTAQATF
                     PVDRMLARLSSTVAVVPELREYAPTIEQQFQKLAAEAITVQRVHGDLHLGQVLRTPES
                     WLLIDFEGEPGQPLDERRAPDSPLRDVAGVLRSFEYAAYGPLVDQATDKQLAARAREW
                     VERNRAAFCDGYAVASGIDPRDSALLLGAYELDKAVYETGYETRHRPGWLPIPLRSIA
                     RLTAS"
     misc_feature    154307..155596
                     /gene="mak"
                     /locus_tag="Rv0127"
                     /note="Predicted trehalose synthase [Carbohydrate
                     transport and metabolism]; Region: Ble; COG3281"
                     /db_xref="CDD:225820"
     gene            155667..156446
                     /locus_tag="Rv0128"
                     /db_xref="GeneID:886878"
     CDS             155667..156446
                     /locus_tag="Rv0128"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214642.1"
                     /db_xref="GeneID:886878"
                     /translation="MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQ
                     RAVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAA
                     GVDIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIE
                     RHLAGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLH
                     ADRRGLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS"
     misc_feature    155667..156320
                     /locus_tag="Rv0128"
                     /note="Uncharacterized membrane protein YoaK, UPF0700
                     family [Function unknown]; Region: YoaK; COG3619"
                     /db_xref="CDD:226146"
     gene            complement(156578..157600)
                     /gene="fbpC"
                     /locus_tag="Rv0129c"
                     /gene_synonym="85C; fbpC2; mpt45"
                     /db_xref="GeneID:886885"
     CDS             complement(156578..157600)
                     /gene="fbpC"
                     /locus_tag="Rv0129c"
                     /gene_synonym="85C; fbpC2; mpt45"
                     /experiment="DESCRIPTION:Gene expression and protein
                     characterization[PMID:11940150]"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:10200974]"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:12010501]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="fibronectin-binding protein C, secreted antigen
                     85c,mycolyl transferase 85C"
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol
                     acyltransferase/mycolyltransferase Ag85C"
                     /protein_id="YP_177694.1"
                     /db_xref="GeneID:886885"
                     /translation="MTFFEQVRRLRSAATTLPRRLAIAAMGAVLVYGLVGTFGGPATA
                     GAFSRPGLPVEYLQVPSASMGRDIKVQFQGGGPHAVYLLDGLRAQDDYNGWDINTPAF
                     EEYYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFLTREMPAWLQANKGVS
                     PTGNAAVGLSMSGGSALILAAYYPQQFPYAASLSGFLNPSEGWWPTLIGLAMNDSGGY
                     NANSMWGPSSDPAWKRNDPMVQIPRLVANNTRIWVYCGNGTPSDLGGDNIPAKFLEGL
                     TLRTNQTFRDTYAADGGRNGVFNFPPNGTHSWPYWNEQLVAMKADIQHVLNGATPPAA
                     PAAPAA"
     misc_feature    complement(156617..157579)
                     /gene="fbpC"
                     /locus_tag="Rv0129c"
                     /gene_synonym="85C; fbpC2; mpt45"
                     /note="S-formylglutathione hydrolase FrmB [Defense
                     mechanisms]; Region: FrmB; COG0627"
                     /db_xref="CDD:223700"
     gene            157847..158302
                     /gene="htdZ"
                     /locus_tag="Rv0130"
                     /db_xref="GeneID:886876"
     CDS             157847..158302
                     /gene="htdZ"
                     /locus_tag="Rv0130"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:16963641]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyl-thioester dehydratase"
                     /protein_id="NP_214644.1"
                     /db_xref="GeneID:886876"
                     /translation="MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWI
                     HVDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPV
                     GSRVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA"
     misc_feature    157853..158299
                     /gene="htdZ"
                     /locus_tag="Rv0130"
                     /note="NodN (nodulation factor N) contains a single hot
                     dog fold similar to those of the peroxisomal
                     Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the
                     fatty acid synthase beta subunit. Rhizobium and related
                     species form nodules on the roots of their...; Region:
                     NodN; cd03450"
                     /db_xref="CDD:239534"
     misc_feature    order(157949..157951,157964..157966,157970..157972,
                     157979..157981,158024..158026,158033..158038)
                     /gene="htdZ"
                     /locus_tag="Rv0130"
                     /note="putative active site [active]"
                     /db_xref="CDD:239534"
     misc_feature    order(157964..157966,157970..157972,157979..157981,
                     158033..158035)
                     /gene="htdZ"
                     /locus_tag="Rv0130"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:239534"
     gene            complement(158315..159658)
                     /gene="fadE1"
                     /locus_tag="Rv0131c"
                     /db_xref="GeneID:886874"
     CDS             complement(158315..159658)
                     /gene="fadE1"
                     /locus_tag="Rv0131c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase FadE1"
                     /protein_id="NP_214645.1"
                     /db_xref="GeneID:886874"
                     /translation="MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLV
                     ALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSR
                     WAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLF
                     VTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTP
                     GIEIVRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHA
                     MRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWL
                     IDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLG
                     IADGATELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF"
     misc_feature    complement(158426..159589)
                     /gene="fadE1"
                     /locus_tag="Rv0131c"
                     /note="Acyl-CoA dehydrogenase; Region: ACAD; cl09933"
                     /db_xref="CDD:324545"
     misc_feature    complement(order(158462..158464,158468..158470,
                     158474..158482,159107..159109,159113..159115,
                     159215..159217,159221..159223,159311..159313))
                     /gene="fadE1"
                     /locus_tag="Rv0131c"
                     /note="active site"
                     /db_xref="CDD:173838"
     gene            complement(159700..160782)
                     /gene="fgd2"
                     /locus_tag="Rv0132c"
                     /db_xref="GeneID:886877"
     CDS             complement(159700..160782)
                     /gene="fgd2"
                     /locus_tag="Rv0132c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /inference="protein motif:PROSITE:PS00013"
                     /codon_start=1
                     /transl_table=11
                     /product="F420-dependent glucose-6-phosphate
                     dehydrogenase"
                     /protein_id="NP_214646.1"
                     /db_xref="GeneID:886877"
                     /translation="MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGV
                     GVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNS
                     TSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGN
                     YRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSA
                     TLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAAR
                     AADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAV
                     PFLHFPQDDPITAIDFYRTNVLPELR"
     misc_feature    complement(159703..160779)
                     /gene="fgd2"
                     /locus_tag="Rv0132c"
                     /note="TAT-translocated F420-dependent dehydrogenase, FGD2
                     family; Region: ArgArg_F420; TIGR04465"
                     /db_xref="CDD:275258"
     gene            160869..161474
                     /locus_tag="Rv0133"
                     /db_xref="GeneID:886873"
     CDS             160869..161474
                     /locus_tag="Rv0133"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="GCN5-like N-acetyltransferase"
                     /protein_id="NP_214647.1"
                     /db_xref="GeneID:886873"
                     /translation="MTPQARPARRADVRELSRTMARAFYDDPVMSWLLSNDNARTARL
                     TRLFATIVRHQHLAGGGVEVARGAAGIGGAALWDPPDRWRESRRQQLAMTPGFLRVFG
                     FRTAKARAALDVMMRVHPEEPHWYLAAIGSDPTVRGQGFGQVLMRSRLDRCDAEHCPA
                     YLESTKPENVPYYQRFGFRVTREIALPDAGPPLWAMWREPR"
     misc_feature    <161220..161402
                     /locus_tag="Rv0133"
                     /note="Acetyltransferase (GNAT) family; Region:
                     Acetyltransf_1; pfam00583"
                     /db_xref="CDD:306954"
     gene            161771..162673
                     /gene="ephF"
                     /locus_tag="Rv0134"
                     /db_xref="GeneID:886871"
     CDS             161771..162673
                     /gene="ephF"
                     /locus_tag="Rv0134"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="epoxide hydrolase EphF"
                     /protein_id="NP_214648.1"
                     /db_xref="GeneID:886871"
                     /translation="MIALPALEGVEHRHVDVAEGVRIHVADAGPADGPAVMLVHGFPQ
                     NWWEWRDLIGPLAADGNRVLCPDLRGAGWSSAPRSRYTKTEMADDLAAVLDGLGVAKV
                     KLVAHDWGGPVAFIMMLRHPEKVTGFFGVNTVAPWVKRDLGMLRNMWRFWYQIPMSLP
                     VIGPRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAGSRWYRTFQT
                     REMLRWLRGEYNDARVDVPVRWLHGTGDPVITPDLLDGYAERASDFEVELVDGVGHWI
                     VEQRPELVLDRVRAFLAAGTEQRD"
     misc_feature    161870..162613
                     /gene="ephF"
                     /locus_tag="Rv0134"
                     /note="alpha/beta hydrolase fold; Region: Abhydrolase_1;
                     pfam00561"
                     /db_xref="CDD:306935"
     gene            complement(162644..163249)
                     /locus_tag="Rv0135c"
                     /db_xref="GeneID:886869"
     CDS             complement(162644..163249)
                     /locus_tag="Rv0135c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214649.1"
                     /db_xref="GeneID:886869"
                     /translation="MTAVAAGALVVETDSFRLRLLDGLVASIGERGYRATTVSDIVRH
                     ARTSKRTFYDRFTSKEQCFLELLLADNETLGNSIRAAVDPNADWHDQIRQAVEAYVTH
                     IESRPAVTLSWIREFPSLGAAAYPVQRRGMEQLTSLLIELSASPGFRRANLPPLNVPL
                     AVILLGGLRELTALTVEDGQPIRNIVEPAVDASIALLGPRS"
     misc_feature    complement(<162911..163201)
                     /locus_tag="Rv0135c"
                     /note="transcriptional regulator BetI; Validated; Region:
                     PRK00767; cl27691"
                     /db_xref="CDD:332512"
     misc_feature    complement(163052..163192)
                     /locus_tag="Rv0135c"
                     /note="Bacterial regulatory proteins, tetR family; Region:
                     TetR_N; pfam00440"
                     /db_xref="CDD:306858"
     gene            163366..164691
                     /gene="cyp138"
                     /locus_tag="Rv0136"
                     /db_xref="GeneID:886868"
     CDS             163366..164691
                     /gene="cyp138"
                     /locus_tag="Rv0136"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00086"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome P450 Cyp138"
                     /protein_id="NP_214650.1"
                     /db_xref="GeneID:886868"
                     /translation="MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVR
                     RYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGD
                     DHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILR
                     AIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVID
                     KLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLG
                     WAFERLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGE
                     WVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAA
                     FANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR"
     misc_feature    163414..164688
                     /gene="cyp138"
                     /locus_tag="Rv0136"
                     /note="Cytochrome P450 [Secondary metabolites
                     biosynthesis, transport and catabolism, Defense
                     mechanisms]; Region: CypX; COG2124"
                     /db_xref="CDD:225035"
     gene            complement(164712..165260)
                     /gene="msrA"
                     /locus_tag="Rv0137c"
                     /db_xref="GeneID:886865"
     CDS             complement(164712..165260)
                     /gene="msrA"
                     /locus_tag="Rv0137c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide methionine sulfoxide reductase MsrA"
                     /protein_id="NP_214651.1"
                     /db_xref="GeneID:886865"
                     /translation="MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATY
                     RNHGTHAEAVEIIFDPTVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQ
                     QKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPG
                     WRLPRRTAESALRASLSPELGT"
     misc_feature    complement(164763..165257)
                     /gene="msrA"
                     /locus_tag="Rv0137c"
                     /note="methionine sulfoxide reductase A; Provisional;
                     Region: PRK14054"
                     /db_xref="CDD:237597"
     gene            165323..165826
                     /locus_tag="Rv0138"
                     /db_xref="GeneID:886863"
     CDS             165323..165826
                     /locus_tag="Rv0138"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214652.1"
                     /db_xref="GeneID:886863"
                     /translation="MSASEFSRAELAAAFEKFEKTVARAAATRDWDCWVQHYTPDVEY
                     IEHAAGIMRGRQRVRAWIQETMTTFPGSHMVAFPSLWSVIDESTGRIICELDNPMLDP
                     GDGSVISATNISIITYAGNGQWCRQEDIYNPLRFLRAAMKWCRKAQELGTLDEDAARW
                     MRRHGGP"
     misc_feature    165392..165700
                     /locus_tag="Rv0138"
                     /note="SnoaL-like domain; Region: SnoaL_2; pfam12680"
                     /db_xref="CDD:315371"
     gene            165827..166849
                     /locus_tag="Rv0139"
                     /db_xref="GeneID:886860"
     CDS             165827..166849
                     /locus_tag="Rv0139"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214653.1"
                     /db_xref="GeneID:886860"
                     /translation="MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTR
                     SIDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNV
                     LDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYA
                     HDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAVGVDDAARA
                     LILAAERGRNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLR
                     ARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVG
                     KDPAAS"
     misc_feature    165842..166801
                     /locus_tag="Rv0139"
                     /note="Short-chain dehydrogenases/reductases (SDR);
                     Region: SDR; cl25409"
                     /db_xref="CDD:330230"
     misc_feature    order(165851..165853,165857..165862,165866..165868,
                     165935..165943,166055..166063,166175..166183,
                     166259..166261,166271..166273,166340..166351)
                     /locus_tag="Rv0139"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:187535"
     misc_feature    order(166109..166111,166181..166183,166259..166261,
                     166271..166273)
                     /locus_tag="Rv0139"
                     /note="active site"
                     /db_xref="CDD:187535"
     gene            166910..167290
                     /locus_tag="Rv0140"
                     /db_xref="GeneID:886859"
     CDS             166910..167290
                     /locus_tag="Rv0140"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214654.1"
                     /db_xref="GeneID:886859"
                     /translation="MSNRIVLEPSADHPITIEPTNRRVQVRVNGEVVADTAAALCLQE
                     ASYPAVQYIPLADVVQDRLIRTETSTYCPFKGEASYYSVTTDAGDIVDDVMWTYENPY
                     PAVAAIAGHVACYPDKAEISIFPG"
     misc_feature    166910..167287
                     /locus_tag="Rv0140"
                     /note="Uncharacterized conserved protein, DUF427 family
                     [Function unknown]; Region: COG2343"
                     /db_xref="CDD:225220"
     gene            complement(167271..167681)
                     /locus_tag="Rv0141c"
                     /db_xref="GeneID:886872"
     CDS             complement(167271..167681)
                     /locus_tag="Rv0141c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214655.1"
                     /db_xref="GeneID:886872"
                     /translation="MTPFDDPQAELAWMFLQSLCEGGDLDEGFALLSNDFTYWSIVTR
                     TELDKKTFRRAVERRKQVFEVNIELIRCVNEGETVVVEGHCDGVSADRTRYDSPFVCI
                     FETRDGMIISLREYSDTQSLAEVYPVACATPGRC"
     misc_feature    complement(167274..167669)
                     /locus_tag="Rv0141c"
                     /note="Ketosteroid isomerase-related protein [General
                     function prediction only]; Region: YesE; COG3631"
                     /db_xref="CDD:226158"
     gene            167711..168637
                     /locus_tag="Rv0142"
                     /db_xref="GeneID:886858"
     CDS             167711..168637
                     /locus_tag="Rv0142"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214656.1"
                     /db_xref="GeneID:886858"
                     /translation="MRSIDVVVEAVVTFAGAAGFAHTLAPLRRGQQDPCFRVPGDGTI
                     WRTSLLPTGPVTARISRAGRDAARCVAWGSGAEEFVDMAPAMLGAADDASDFVPLHPA
                     VAAAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQAPGPAPP
                     GMRVPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLERLVSLPAARAAEALT
                     SLPGVGVWTAAETTQRVFGDADAVSVGDYHIPKMIGWTLVGRPVDDAGMLELLEPMRP
                     HRHRVVRLLEASGLAREPRRGPRLPVQNIRAL"
     misc_feature    167744..168613
                     /locus_tag="Rv0142"
                     /note="3-methyladenine DNA glycosylase/8-oxoguanine DNA
                     glycosylase [Replication, recombination and repair];
                     Region: AlkA; COG0122"
                     /db_xref="CDD:223200"
     gene            complement(168704..170182)
                     /locus_tag="Rv0143c"
                     /db_xref="GeneID:886856"
     CDS             complement(168704..170182)
                     /locus_tag="Rv0143c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214657.1"
                     /db_xref="GeneID:886856"
                     /translation="MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRFGVSIRSAGYL
                     RKWFLLGITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGFAR
                     PWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGRAVLVKMVASA
                     LTIGSGGSGGREGPTAQISAGFCSLLTRRLNLSNEDGRTAVALGIGAGIGAIFAAPLG
                     GAALGASIPYRDDFDYRNLLPGFIASGTAYAVLGAFLGFDPLFGYIDAEYRFEKAWPL
                     LWFVVIGLIAAAVGYLYARVFHASVAITRRLPGGPVLKPAIGGLLVGLLGLPIPQILS
                     SGYGWAQLAADRGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVG
                     AAIWRLGELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVPGA
                     IIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA"
     misc_feature    complement(168716..170056)
                     /locus_tag="Rv0143c"
                     /note="H+/Cl- antiporter ClcA [Inorganic ion transport and
                     metabolism]; Region: ClcA; COG0038"
                     /db_xref="CDD:223116"
     misc_feature    complement(order(169034..169048,169661..169675,
                     169766..169780))
                     /locus_tag="Rv0143c"
                     /note="Cl- selectivity filter; other site"
                     /db_xref="CDD:238233"
     misc_feature    complement(order(169040..169048,169664..169669,
                     169769..169771,169775..169777))
                     /locus_tag="Rv0143c"
                     /note="Cl- binding residues [ion binding]; other site"
                     /db_xref="CDD:238233"
     misc_feature    complement(169667..169669)
                     /locus_tag="Rv0143c"
                     /note="pore gating glutamate residue; other site"
                     /db_xref="CDD:238233"
     misc_feature    complement(order(168818..168823,168842..168844,
                     168866..168868,168890..168892,168899..168901,
                     169436..169438,169457..169459,169505..169507,
                     169532..169534))
                     /locus_tag="Rv0143c"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238233"
     gene            170284..171126
                     /locus_tag="Rv0144"
                     /db_xref="GeneID:886854"
     CDS             170284..171126
                     /locus_tag="Rv0144"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214658.1"
                     /db_xref="GeneID:886854"
                     /translation="MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGA
                     KLTSSVASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQVFS
                     ERGYDGATFQEIAVRADLTRPAINHYFANKRVLYQEVVEQTHELVIVAGIERARREPT
                     LMGRLAVVVDFAMEADAQYPASTAFLATTVLESQRHPELSRTENDAVRATREFLVWAV
                     NDAIERGELAADVDVSSLAETLLVVLCGVGFYIGFVGSYQRMATITDSFQQLLAGTLW
                     RPPT"
     misc_feature    170521..171060
                     /locus_tag="Rv0144"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            171215..172168
                     /locus_tag="Rv0145"
                     /db_xref="GeneID:886851"
     CDS             171215..172168
                     /locus_tag="Rv0145"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosylmethionine-dependent
                     methyltransferase"
                     /protein_id="NP_214659.1"
                     /db_xref="GeneID:886851"
                     /translation="MTELDDVSSLPSSRRTAGDTWAITESVGATALGVAAARAVETAA
                     TNPLIRDEFAKVLVSSAGTAWARLADADLAWLDGDQLGRRVHRVACDYQAVRTHFFDE
                     YFGAAVDAGVRQVVILAAGLDARAYRLNWPAGTVVYEIDQPSVLEYKAGILQSHGAVP
                     TARRHAVAVDLRDDWPAALIAAGFDGTQPTAWLAEGLLPYLPGDAADRLFDMVTALSA
                     PGSQVAVEAFTMNTKGNTQRWNRMRERLGLDIDVQALTYHEPDRSDAAQWLATHGWQV
                     HSVSNREEMARLGRAIPQDLVDETVRTTLLRGRLVTPAQPA"
     misc_feature    171254..172150
                     /locus_tag="Rv0145"
                     /note="O-Methyltransferase involved in polyketide
                     biosynthesis [Secondary metabolites biosynthesis,
                     transport and catabolism]; Region: YktD; COG3315"
                     /db_xref="CDD:225852"
     gene            172211..173143
                     /locus_tag="Rv0146"
                     /db_xref="GeneID:886849"
     CDS             172211..173143
                     /locus_tag="Rv0146"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosylmethionine-dependent
                     methyltransferase"
                     /protein_id="NP_214660.1"
                     /db_xref="GeneID:886849"
                     /translation="MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLL
                     VTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAG
                     IRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPA
                     DLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAET
                     APVHGEERRAEMRARFKKVADVLGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQ
                     RAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL"
     misc_feature    172292..173074
                     /locus_tag="Rv0146"
                     /note="methyltransferase, TIGR00027 family; Region:
                     mthyl_TIGR00027"
                     /db_xref="CDD:272862"
     gene            173238..174758
                     /locus_tag="Rv0147"
                     /db_xref="GeneID:886847"
     CDS             173238..174758
                     /locus_tag="Rv0147"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00070"
                     /inference="protein motif:PROSITE:PS00687"
                     /note="(NAD+) dependent; Belongs to the aldehyde
                     dehydrogenases family"
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase"
                     /protein_id="NP_214661.1"
                     /db_xref="GeneID:886847"
                     /translation="MSDRVKAVAPPDGRTMMTTESVARKTQKSETEAPREPAPVSDEK
                     QTDVAKTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLDRNPFE
                     AYLADIATTSAEAKYAAKRVRRWMRRRYLLLEVPQLPGRGWVEYEPYGTVLIIGAWNY
                     PFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTELVYRYLDTEAIAVVQGDGAVSQ
                     ELIAQGFDRVMFTGGTEIGRKVYEGAAPHLTPVTLELGGKSPVIVAADADVDVAAKRI
                     AWIKLLNAGQTCVAPDYVLADATVRDELVSKITAALTKFRSGAPQGMRIVNQRQFDRL
                     SGYLAAAKTDAAADGGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVV
                     TVKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQVSTAKLP
                     FGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPPYTERAIKVARRLF"
     misc_feature    173388..174674
                     /locus_tag="Rv0147"
                     /note="ALDH subfamily: Coniferyl aldehyde dehydrogenase,
                     ALDH families 3, 13, and 14, and other related proteins;
                     Region: ALDH_F3-13-14_CALDH-like; cd07087"
                     /db_xref="CDD:143406"
     misc_feature    order(173706..173714,173790..173792,173877..173879,
                     173931..173933,174216..174218,174222..174227,
                     174234..174236,174384..174386,174390..174392)
                     /locus_tag="Rv0147"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:143406"
     misc_feature    order(173712..173714,173997..173999,174090..174092,
                     174099..174101)
                     /locus_tag="Rv0147"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143406"
     gene            174833..175693
                     /locus_tag="Rv0148"
                     /db_xref="GeneID:886845"
     CDS             174833..175693
                     /locus_tag="Rv0148"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00061"
                     /note="belongs to the short-chain
                     dehydrogenases/reductases (SDR) family"
                     /codon_start=1
                     /transl_table=11
                     /product="short-chain type dehydrogenase/reductase"
                     /protein_id="NP_214662.1"
                     /db_xref="GeneID:886845"
                     /translation="MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDG
                     TGAGSAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGI
                     LRDGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFG
                     QTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFV
                     APVVAYLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDL
                     SGAKIAGFKL"
     misc_feature    174842..175558
                     /locus_tag="Rv0148"
                     /note="(3R)-hydroxyacyl-CoA dehydrogenase-like,
                     classical(c)-like SDRs; Region:
                     hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353"
                     /db_xref="CDD:187611"
     misc_feature    order(174869..174871,174878..174886,174938..174946,
                     174950..174952,175046..175051,175127..175138,
                     175196..175201,175277..175285,175322..175324,
                     175334..175336,175412..175420,175424..175435)
                     /locus_tag="Rv0148"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:187611"
     misc_feature    order(174917..174919,175151..175159,175163..175171,
                     175178..175183,175190..175192,175202..175207,
                     175214..175216,175223..175228,175235..175240,
                     175286..175312,175316..175318,175325..175330,
                     175337..175342,175346..175354,175358..175366,
                     175370..175375,175379..175384,175388..175390,
                     175457..175459,175466..175471,175481..175483,
                     175490..175495,175499..175507,175526..175528,
                     175538..175546,175550..175558)
                     /locus_tag="Rv0148"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:187611"
     misc_feature    order(175199..175201,175283..175285,175322..175324,
                     175334..175336)
                     /locus_tag="Rv0148"
                     /note="active site"
                     /db_xref="CDD:187611"
     gene            175700..176668
                     /locus_tag="Rv0149"
                     /db_xref="GeneID:886843"
     CDS             175700..176668
                     /locus_tag="Rv0149"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS01162"
                     /note="belongs to the zinc-containing alcohol
                     dehydrogenase family, quinone oxidoreductase subfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="quinone oxidoreductase"
                     /protein_id="NP_214663.1"
                     /db_xref="GeneID:886843"
                     /translation="MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDL
                     LLTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVA
                     NVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAK
                     AMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGP
                     TFDDALGVLAIDGKLLLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAAL
                     FAWGLNQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP"
     misc_feature    175700..176662
                     /locus_tag="Rv0149"
                     /note="Quinone oxidoreductase (QOR); Region: QOR1;
                     cd08241"
                     /db_xref="CDD:176203"
     misc_feature    order(175817..175822,176060..176062,176072..176074,
                     176135..176137,176144..176152,176210..176215,
                     176225..176227,176270..176272,176339..176341,
                     176405..176410,176414..176419,176480..176488,
                     176633..176635,176639..176641,176645..176647)
                     /locus_tag="Rv0149"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:176203"
     gene            complement(176665..176952)
                     /locus_tag="Rv0150c"
                     /db_xref="GeneID:886840"
     CDS             complement(176665..176952)
                     /locus_tag="Rv0150c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214664.1"
                     /db_xref="GeneID:886840"
                     /translation="MLTLPDDRAPTGLPDPGIEALAHTKIASTISTVVADGYAVVLST
                     ADIANSLLANAIGYPIAASVALVTPAAGANSSCWPADPSQHHRIAESRACA"
     gene            complement(177543..179309)
                     /gene="PE1"
                     /locus_tag="Rv0151c"
                     /db_xref="GeneID:886857"
     CDS             complement(177543..179309)
                     /gene="PE1"
                     /locus_tag="Rv0151c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="Member of the Mycobacterium tuberculosis PE family"
                     /codon_start=1
                     /transl_table=11
                     /product="PE family protein PE1"
                     /protein_id="YP_177695.1"
                     /db_xref="GeneID:886857"
                     /translation="MAPFGFTPKARHNRGVALRSTYRLDGWVMGPVDKEGWGLSYVFA
                     QPSVLAAAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQFQA
                     ISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEATAGLFKPTSPPVLPPMFNQN
                     TAIIMGGTGSPIPTPSYVNAITTLFIDPVVSNPVVKALVTPEELYPITGVKSLPFQTS
                     VQLGLQILDGAIWEQINAGNHVTVFGYSQSAVIASLEMQHLISLGPNAPSPSQLNFIL
                     IGNEMNPNGGILARIPGLNVTTLGLPFYGATPDNPYPTTTYTLEYDGFADFPRYPLNV
                     LSDINAVFGILTVHTTYADLTPAQIASATQLPTQGTTSNTYYIIETEHLPLLAPLRAI
                     PVIGPPLAALVEPNLEVIVNLGYGDPRFGYSTSPANVPTPFGLFPDVPASVVADALVA
                     GTQQGVNDFMVELPAALNTLPQTPMPAFPPYVPTLLPPPPPPQPATLINIADTFASVV
                     STGYSILLPTADLGLAFVTILPAYDLTLFVNQLAAGNLRAAIELPLAATIGLAALGGM
                     IEFIAIVVTLADITQQLQSFSI"
     misc_feature    complement(178956..179192)
                     /gene="PE1"
                     /locus_tag="Rv0151c"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:307197"
     misc_feature    complement(178065..178724)
                     /gene="PE1"
                     /locus_tag="Rv0151c"
                     /note="PE-PPE domain; Region: PE-PPE; pfam08237"
                     /db_xref="CDD:311933"
     gene            complement(179319..180896)
                     /gene="PE2"
                     /locus_tag="Rv0152c"
                     /db_xref="GeneID:886838"
     CDS             complement(179319..180896)
                     /gene="PE2"
                     /locus_tag="Rv0152c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="Member of the Mycobacterium tuberculosis PE family"
                     /codon_start=1
                     /transl_table=11
                     /product="PE family protein PE2"
                     /protein_id="YP_177696.1"
                     /db_xref="GeneID:886838"
                     /translation="MRCRPPSRNRSAHTARNTRPCSLKSRRFTVRFHQTLAAAANSYA
                     DAEAAIASTRQNQLAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPLPPPSMLTPPI
                     RCRSVRRALQAVFTPEELYPLTGVRSLVLNTSVEEGLTILHDAIMVELATTGNAVTVF
                     GWSQSAIIASLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDL
                     TFYGATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHTKYLDLTPAQ
                     VEGATKLPTSPGYTGVTDYYIIRTENRPLLQPLRAVPVIGDPLADLIQPNLKVIVNLG
                     YGDPNYGYSTSYADVRTPFGLWPNVPPQVIADALAAGTQEGILDFTADLQALSAQPLT
                     LPQIQLPQPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTVDIALALVTTLPLYT
                     TQLFVRQLAAGNLINAIGYPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLT
                     DSRRHRRPPTTVYRPRQ"
     misc_feature    complement(179892..180563)
                     /gene="PE2"
                     /locus_tag="Rv0152c"
                     /note="PE-PPE domain; Region: PE-PPE; pfam08237"
                     /db_xref="CDD:311933"
     gene            complement(181155..181985)
                     /gene="ptbB"
                     /locus_tag="Rv0153c"
                     /gene_synonym="MPtpB"
                     /db_xref="GeneID:886842"
     CDS             complement(181155..181985)
                     /gene="ptbB"
                     /locus_tag="Rv0153c"
                     /gene_synonym="MPtpB"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:10986245]"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:17584180]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="MPtpB, potent and selective inhibitor is an
                     isoxazole compound"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphotyrosine protein phosphatase"
                     /protein_id="NP_214667.1"
                     /db_xref="GeneID:886842"
                     /translation="MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATL
                     RRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLL
                     TNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHC
                     FAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPE
                     VVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
                     "
     misc_feature    complement(181158..181973)
                     /gene="ptbB"
                     /locus_tag="Rv0153c"
                     /gene_synonym="MPtpB"
                     /note="Tyrosine phosphatase family; Region:
                     Y_phosphatase3; pfam13350"
                     /db_xref="CDD:315917"
     gene            complement(181987..183198)
                     /gene="fadE2"
                     /locus_tag="Rv0154c"
                     /db_xref="GeneID:886836"
     CDS             complement(181987..183198)
                     /gene="fadE2"
                     /locus_tag="Rv0154c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase FadE2"
                     /protein_id="NP_214668.1"
                     /db_xref="GeneID:886836"
                     /translation="MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRAAGPADHTAPPI
                     IEELKTKAKDRGLWNLFLSAESGLTNLEYAPLAEMTGWSMEIAPEALNCAAPDTGNME
                     ILHMFGTEQQRAQWLRPLLDGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGR
                     KWWTSGAADPRCKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRH
                     GHCEIDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALMVNRV
                     RNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGNKEARHLVAMIKA
                     VAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGWHRAMRIFDGPDEVHLRSIARAELS
                     REKSTFAAAVT"
     misc_feature    complement(182023..183192)
                     /gene="fadE2"
                     /locus_tag="Rv0154c"
                     /note="Acyl-CoA dehydrogenases similar to fadE2; Region:
                     ACAD_FadE2; cd01155"
                     /db_xref="CDD:173844"
     misc_feature    complement(order(182668..182670,182674..182676,
                     182773..182778,182797..182799,182803..182805))
                     /gene="fadE2"
                     /locus_tag="Rv0154c"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173844"
     misc_feature    complement(order(182071..182076,182437..182439,
                     182446..182451,182470..182472,182704..182706))
                     /gene="fadE2"
                     /locus_tag="Rv0154c"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173844"
     misc_feature    complement(182071..182073)
                     /gene="fadE2"
                     /locus_tag="Rv0154c"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173844"
     gene            183622..184722
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /db_xref="GeneID:886832"
     CDS             183622..184722
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="catalytic part; Probable pntAa,first part of NAD(P)
                     transhydrogenase subunit alpha"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P) transhydrogenase subunit alpha PntAa"
                     /protein_id="NP_214669.1"
                     /db_xref="GeneID:886832"
                     /translation="MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVE
                     AGAGERALLPDELYTAVGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRN
                     ADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPM
                     LTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLD
                     LGISASGEGGYARELTDDERAQQQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVE
                     AMKPGSVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPATMPEHASELYSKNIT
                     ALLDLLIKDGRLAPDFDDEVIAQSCVTRGKDS"
     misc_feature    183649..184710
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /note="Rubrum transdehydrogenase NAD-binding and catalytic
                     domains; Region: Rubrum_tdh; cd05304"
                     /db_xref="CDD:240629"
     misc_feature    order(183688..183690,183853..183855,183910..183912,
                     184489..184491,184567..184569,184573..184575)
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:240629"
     misc_feature    order(183775..183777,184009..184014,184039..184044,
                     184051..184056,184063..184068,184072..184077,
                     184081..184098,184102..184104,184108..184116,
                     184123..184125,184192..184197,184459..184464,
                     184588..184593,184603..184605,184612..184617)
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240629"
     misc_feature    order(183994..183999,184009..184011,184018..184020,
                     184027..184029,184150..184161,184219..184227,
                     184309..184311,184342..184344,184393..184401,
                     184420..184422,184426..184428)
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:240629"
     misc_feature    order(184000..184005,184009..184011,184039..184041,
                     184168..184173,184192..184194,184240..184245,
                     184249..184260)
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /note="trimer interface B [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240629"
     misc_feature    order(184099..184113,184120..184122,184129..184131,
                     184198..184200,184204..184206)
                     /gene="pntAa"
                     /locus_tag="Rv0155"
                     /note="trimer interface A [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240629"
     gene            184723..185055
                     /gene="pntAb"
                     /locus_tag="Rv0156"
                     /db_xref="GeneID:886890"
     CDS             184723..185055
                     /gene="pntAb"
                     /locus_tag="Rv0156"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="integral membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P) transhydrogenase subunit alpha PntAb"
                     /protein_id="NP_214670.1"
                     /db_xref="GeneID:886890"
                     /translation="MYNELLENLAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGI
                     VVLGALVVFGEIEHPSLVLQVILFVAVVFGTLNVIGGFIVTDRMLGMFKAKKPAVPAK
                     PDRDEALR"
     misc_feature    184747..185001
                     /gene="pntAb"
                     /locus_tag="Rv0156"
                     /note="4TM region of pyridine nucleotide transhydrogenase,
                     mitoch; Region: PNTB_4TM; pfam12769"
                     /db_xref="CDD:315446"
     gene            185052..186479
                     /gene="pntB"
                     /locus_tag="Rv0157"
                     /db_xref="GeneID:886830"
     CDS             185052..186479
                     /gene="pntB"
                     /locus_tag="Rv0157"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P) transhydrogenase subunit beta PntB"
                     /protein_id="NP_214671.1"
                     /db_xref="GeneID:886830"
                     /translation="MNLHYLVEILYIISFSLFIYGLMGLTGPKTAVRGNLIAAAGMTI
                     AVAATLVMIRHTSQWPLIIAGLVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVAL
                     IALSEFIDTTGFSAFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRP
                     IGLGKAQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMVVLP
                     IGGADMPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGSILTNLMAKAMNRS
                     IPAIVAGGFGGGGVAPSGGGDDKHVKATSAADAAIQMAYANQVIVVPGYGLAVAQAQH
                     AVKDLATLLEDRGVPVKYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFART
                     DVTIVIGANDVTNPAARNETSSPIYGMPILNVDKSRSVIVLKRSMNSGFAGIDNPLFY
                     ADGTTMLFGDAKKSVTEVSEELKAL"
     misc_feature    185055..186467
                     /gene="pntB"
                     /locus_tag="Rv0157"
                     /note="NAD/NADP transhydrogenase beta subunit [Energy
                     production and conversion]; Region: PntB; COG1282"
                     /db_xref="CDD:224201"
     gene            complement(186495..186623)
                     /locus_tag="Rv0157A"
                     /db_xref="GeneID:3205086"
     CDS             complement(186495..186623)
                     /locus_tag="Rv0157A"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_007408797.1"
                     /db_xref="GeneID:3205086"
                     /translation="MMDPSPDYDVSDEIEFFFRYLTWGLRGVETGDGYPPPAYPPV"
     gene            186785..187429
                     /locus_tag="Rv0158"
                     /db_xref="GeneID:886828"
     CDS             186785..187429
                     /locus_tag="Rv0158"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214672.1"
                     /db_xref="GeneID:886828"
                     /translation="MPSDTSPNGLSRREELLAVATKLFAARGYHGTRMDDVADVIGLN
                     KATVYHYYASKSLILFDIYRQAAEGTLAAVHDDPSWTAREALYQYTVRLLTAIASNPE
                     RAAVYFQEQPYITEWFTSEQVAEVREKEQQVYEHVHGLIDRGIASGEFYECDSHVVAL
                     GYIGMTLGSYRWLRPSGRRTAKEIAAEFSTALLRGLIRDESIRNQSPLGTRKET"
     misc_feature    186818..187378
                     /locus_tag="Rv0158"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            complement(187433..188839)
                     /gene="PE3"
                     /locus_tag="Rv0159c"
                     /db_xref="GeneID:886826"
     CDS             complement(187433..188839)
                     /gene="PE3"
                     /locus_tag="Rv0159c"
                     /codon_start=1
                     /transl_table=11
                     /product="PE family protein PE3"
                     /protein_id="YP_177697.1"
                     /db_xref="GeneID:886826"
                     /translation="MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAA
                     DEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTA
                     GSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTP
                     EQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMA
                     LPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMY
                     TGQYDGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTH
                     YYMFLTQDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPI
                     NPIAVASALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTEL
                     SVLSGALGSVARLIPPIA"
     misc_feature    complement(188606..188839)
                     /gene="PE3"
                     /locus_tag="Rv0159c"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:307197"
     misc_feature    complement(187715..188383)
                     /gene="PE3"
                     /locus_tag="Rv0159c"
                     /note="PE-PPE domain; Region: PE-PPE; pfam08237"
                     /db_xref="CDD:311933"
     gene            complement(188931..190439)
                     /gene="PE4"
                     /locus_tag="Rv0160c"
                     /db_xref="GeneID:886825"
     CDS             complement(188931..190439)
                     /gene="PE4"
                     /locus_tag="Rv0160c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="PE family protein PE4"
                     /protein_id="YP_177698.1"
                     /db_xref="GeneID:886825"
                     /translation="MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAG
                     DEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHAL
                     DTINAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVT
                     DINKAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLAL
                     DNKVVAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYI
                     PFLDVPFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPE
                     LMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRV
                     LVDLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGL
                     IGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT"
     misc_feature    complement(190185..190439)
                     /gene="PE4"
                     /locus_tag="Rv0160c"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:307197"
     misc_feature    complement(189246..189926)
                     /gene="PE4"
                     /locus_tag="Rv0160c"
                     /note="PE-PPE domain; Region: PE-PPE; pfam08237"
                     /db_xref="CDD:311933"
     gene            190607..191956
                     /locus_tag="Rv0161"
                     /db_xref="GeneID:886835"
     CDS             190607..191956
                     /locus_tag="Rv0161"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214675.1"
                     /db_xref="GeneID:886835"
                     /translation="MLTSLVSAVGSHHVTTDPDVLAGRSVDHTGRYRGRASALVRPGS
                     AEEVAEVLRVCRDAGAYVTVQGGRTSLVAGTVPEHDDVLLSTERLCVVSDVDTVERRI
                     EIGAGVTLAAVQHAASTAGLVFGVDLSARDTATVGGMASTNAGGLRTVRYGNMGEQVV
                     GLDVALPDGTVLRRHSRVRRDNTGYDLPALFVGAEGTLGVITALDLRLHPTPSHRVTA
                     VCGFAELAALVDAGRMFRDVEGIAALELIDGRAAALTREHLGVRPPVEADWLLLVELA
                     ADHDQTDRLADLLGGARMCGEPAVGVDAAAQQRLWRTRESLAEVLGVYGPPLKFDVSL
                     PLSAISGFARDAVALVHRHVPDSPEALPLLFGHIGEGNLHLNVLRCPPDREPALYAKM
                     MGLIAECGGNVSSEHGVGSRKRAYLGMSRQANDVAAMRRVKAALDPTGYLNAAVLFD"
     misc_feature    190616..191950
                     /locus_tag="Rv0161"
                     /note="FAD/FMN-containing dehydrogenase [Energy production
                     and conversion]; Region: GlcD; COG0277"
                     /db_xref="CDD:223354"
     gene            complement(191984..193135)
                     /gene="adhE1"
                     /locus_tag="Rv0162c"
                     /db_xref="GeneID:886824"
     CDS             complement(191984..193135)
                     /gene="adhE1"
                     /locus_tag="Rv0162c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00059"
                     /note="Belongs to the zinc-containing alcohol
                     dehydrogenase family,class-I subfamily. Cofactor: zinc."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-type alcohol dehydrogenase subunit E"
                     /protein_id="YP_177699.1"
                     /db_xref="GeneID:886824"
                     /translation="MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDP
                     PDRGEVLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAVGQR
                     VVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVSGF
                     ATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQSVAVVGLGGVG
                     MAAVLTALTYTDVRVVAVDQLPEKLSAAKALGAHEIYTPQQATAGGVKAAVVVEAVGH
                     PAALHTAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIP
                     RFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL"
     misc_feature    complement(191999..193093)
                     /gene="adhE1"
                     /locus_tag="Rv0162c"
                     /note="Zn-dependent alcohol dehydrogenase [General
                     function prediction only]; Region: FrmA; COG1062"
                     /db_xref="CDD:223990"
     gene            193117..193572
                     /locus_tag="Rv0163"
                     /db_xref="GeneID:886821"
     CDS             193117..193572
                     /locus_tag="Rv0163"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214677.1"
                     /db_xref="GeneID:886821"
                     /translation="MAALPAPEKLLRSDFPVLWPVGTRWADNDMFGHLNNAVYYQLFD
                     TAINAWINTSTGVDPLAMPVLGIVAESGCRYFSELRFPESLMVGLAVTRLGRSSVTYR
                     LGVFKEPDDAGVITALGHWVHVYVDRTSRRPVPIPEAIRSLLSTACVSG"
     misc_feature    193150..193566
                     /locus_tag="Rv0163"
                     /note="Acyl-CoA thioesterase FadM [Lipid transport and
                     metabolism]; Region: FadM; COG0824"
                     /db_xref="CDD:223894"
     misc_feature    order(193246..193248,193318..193320,193399..193410)
                     /locus_tag="Rv0163"
                     /note="active site"
                     /db_xref="CDD:238329"
     gene            193626..194111
                     /gene="TB18.5"
                     /locus_tag="Rv0164"
                     /db_xref="GeneID:886267"
     CDS             193626..194111
                     /gene="TB18.5"
                     /locus_tag="Rv0164"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_177617.1"
                     /db_xref="GeneID:886267"
                     /translation="MTAISCSPRPRYASRMPVLSKTVEVTADAASIMAIVADIERYPE
                     WNEGVKGAWVLARYDDGRPSQVRLDTAVQGIEGTYIHAVYYPGENQIQTVMQQGELFA
                     KQEQLFSVVATGAASLLTVDMDVQVTMPVPEPMVKMLLNNVLEHLAENLKQRAEQLAA
                     S"
     misc_feature    193671..194090
                     /gene="TB18.5"
                     /locus_tag="Rv0164"
                     /note="Ligand-binding SRPBCC domain of an uncharacterized
                     subfamily of proteins; Region: SRPBCC_2; cd07819"
                     /db_xref="CDD:176861"
     misc_feature    order(193680..193682,193686..193688,193692..193694,
                     193719..193727,193731..193736,193770..193772,
                     193791..193793,193797..193799,193803..193805,
                     193809..193811,193821..193823,193827..193829,
                     193866..193868,193872..193874,193947..193952,
                     193956..193958,193962..193964,193980..193982,
                     193986..193988,193992..193994,193998..194000,
                     194016..194030,194046..194054,194061..194069,
                     194076..194078)
                     /gene="TB18.5"
                     /locus_tag="Rv0164"
                     /note="putative hydrophobic ligand binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:176861"
     gene            complement(194144..194815)
                     /gene="mce1R"
                     /locus_tag="Rv0165c"
                     /db_xref="GeneID:886818"
     CDS             complement(194144..194815)
                     /gene="mce1R"
                     /locus_tag="Rv0165c"
                     /note="belongs to the GntR family of transcriptional
                     regulators."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Mce1R"
                     /protein_id="YP_177700.2"
                     /db_xref="GeneID:886818"
                     /translation="MNAPLSAKPRSQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIR
                     LDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATIAQ
                     ELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLA
                     WFLLNAARYMGAGVRGRPAMGRGRGEQSSAADRRAAPPRHSRRNRAHRLAVHRWGTQA
                     DGGPG"
     misc_feature    complement(<194252..194806)
                     /gene="mce1R"
                     /locus_tag="Rv0165c"
                     /note="DNA-binding transcriptional regulator, GntR family
                     [Transcription]; Region: GntR; COG1802"
                     /db_xref="CDD:224715"
     misc_feature    complement(194570..194758)
                     /gene="mce1R"
                     /locus_tag="Rv0165c"
                     /note="Helix-turn-helix domains; Region: HTH; cl21459"
                     /db_xref="CDD:304362"
     misc_feature    complement(order(194576..194587,194591..194596,
                     194624..194626,194633..194638,194642..194656,
                     194678..194680,194753..194755))
                     /gene="mce1R"
                     /locus_tag="Rv0165c"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:153418"
     misc_feature    complement(<194327..194542)
                     /gene="mce1R"
                     /locus_tag="Rv0165c"
                     /note="FCD domain; Region: FCD; pfam07729"
                     /db_xref="CDD:285030"
     gene            194993..196657
                     /gene="fadD5"
                     /locus_tag="Rv0166"
                     /db_xref="GeneID:886822"
     CDS             194993..196657
                     /gene="fadD5"
                     /locus_tag="Rv0166"
                     /inference="protein motif:PROSITE:PS00455"
                     /codon_start=1
                     /transl_table=11
                     /product="fatty-acid--CoA ligase FadD5"
                     /protein_id="NP_214680.1"
                     /db_xref="GeneID:886822"
                     /translation="MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPA
                     LRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIGAI
                     AVPLNFRLTPTEIAVLVEDCVAHVMLTEAALAPVAIGVRNIQPLLSVIVVAGGSSQDS
                     VFGYEDLLNEAGDVHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYT
                     SGANINSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVT
                     GIFLVPAQWQAVCTEQQARPRDLRLRVLSWGAAPAPDALLRQMSATFPETQILAAFGQ
                     TEMSPVTCMLLGEDAIAKRGSVGRVIPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMS
                     CYWNNPEATAEAFAGGWFHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVL
                     ASHPDIAEVAVIGRADEKWGEVPIAVAAVTNDDLRIEDLGEFLTDRLARYKHPKALEI
                     VDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL"
     misc_feature    195020..196639
                     /gene="fadD5"
                     /locus_tag="Rv0166"
                     /note="long-chain-fatty-acid--CoA ligase; Validated;
                     Region: PRK07786"
                     /db_xref="CDD:169098"
     gene            196861..197658
                     /gene="yrbE1A"
                     /locus_tag="Rv0167"
                     /db_xref="GeneID:886816"
     CDS             196861..197658
                     /gene="yrbE1A"
                     /locus_tag="Rv0167"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214681.1"
                     /db_xref="GeneID:886816"
                     /translation="MTTSTTLGGYVRDQLQTPLTLVGGFFRMCVLTGKALFRWPFQWR
                     EFILQCWFIMRVGFLPTIMVSIPLTVLLIFTLNILLAQFGAADISGSGAAIGAVTQLG
                     PLTTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVLASMLVATLL
                     NGLVITVGLVGGFLFGVYLQNVSGGAYLATLTLITGLPEVVIATIKAATFGLIAGLVG
                     CYRGLTVRGGSKGLGTAVNETVVLCVIALFAVNVILTTIGVRFGTGR"
     misc_feature    196885..197649
                     /gene="yrbE1A"
                     /locus_tag="Rv0167"
                     /note="ABC-type transporter Mla maintaining outer membrane
                     lipid asymmetry, permease component MlaE [Cell
                     wall/membrane/envelope biogenesis]; Region: MlaE; COG0767"
                     /db_xref="CDD:223838"
     gene            197660..198529
                     /gene="yrbE1B"
                     /locus_tag="Rv0168"
                     /db_xref="GeneID:886812"
     CDS             197660..198529
                     /gene="yrbE1B"
                     /locus_tag="Rv0168"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214682.1"
                     /db_xref="GeneID:886812"
                     /translation="MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIG
                     QIAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGN
                     IGVEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIK
                     SISFLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPD
                     DVFWSFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAAL
                     ALYGVDPNFNLTV"
     misc_feature    197681..198508
                     /gene="yrbE1B"
                     /locus_tag="Rv0168"
                     /note="ABC-type transporter Mla maintaining outer membrane
                     lipid asymmetry, permease component MlaE [Cell
                     wall/membrane/envelope biogenesis]; Region: MlaE; COG0767"
                     /db_xref="CDD:223838"
     gene            198534..199898
                     /gene="mce1A"
                     /locus_tag="Rv0169"
                     /gene_synonym="mce1"
                     /db_xref="GeneID:886823"
     CDS             198534..199898
                     /gene="mce1A"
                     /locus_tag="Rv0169"
                     /gene_synonym="mce1"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="Mce family protein Mce1A"
                     /protein_id="YP_177701.1"
                     /db_xref="GeneID:886823"
                     /translation="MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPK
                     TQLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIHLI
                     PANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEINTLFQTLTSIA
                     EKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDLNSRMPQSRHDIQQLAALG
                     DVYADAAPDLFDFLDSSVTTARTINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQR
                     GVADLVPTATLLDTYSPELFCTIRNFYDADPLAKAASGGGNGYSLRTNSEILSGIGIS
                     LLSPLALATNGAAIGIGLVAGLIAPPLAVAANLAGALPGIVGGAPNPYTYPENLPRVN
                     ARGGPGGAPGCWQPITRDLWPAPYLVMDTGASLAPYNHMEVGSPYAVEYVWGRQVGDN
                     TINP"
     misc_feature    198549..199709
                     /gene="mce1A"
                     /locus_tag="Rv0169"
                     /gene_synonym="mce1"
                     /note="ABC-type transporter Mla maintaining outer membrane
                     lipid asymmetry, periplasmic component MlaD [Cell
                     wall/membrane/envelope biogenesis]; Region: MlaD; COG1463"
                     /db_xref="CDD:224380"
     misc_feature    199002..199883
                     /gene="mce1A"
                     /locus_tag="Rv0169"
                     /gene_synonym="mce1"
                     /note="Cholesterol uptake porter CUP1 of Mce4, putative;
                     Region: Mce4_CUP1; pfam11887"
                     /db_xref="CDD:314717"
     gene            199895..200935
                     /gene="mce1B"
                     /locus_tag="Rv0170"
                     /gene_synonym="mceD"
                     /db_xref="GeneID:886810"
     CDS             199895..200935
                     /gene="mce1B"
                     /locus_tag="Rv0170"
                     /gene_synonym="mceD"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="Mce family protein Mce1B"
                     /protein_id="NP_214684.1"
                     /db_xref="GeneID:886810"
                     /translation="MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFS
                     NVSGLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYSDL
                     IGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVFRALDPAKVNN
                     IANALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGEVVKNLNIVLDTTVKHRKEF
                     DETVNNLENLITGLRNHSDQLAGGLAHISNGAGTVADLLAENRTLVRKAVSYLDAIQQ
                     PVIDQRVELDDLLHKTPTALTALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVK
                     LFSQPTGRCTPQ"
     misc_feature    199919..200788
                     /gene="mce1B"
                     /locus_tag="Rv0170"
                     /gene_synonym="mceD"
                     /note="virulence factor Mce family protein; Region:
                     Mtu_fam_mce; TIGR00996"
                     /db_xref="CDD:273384"
     gene            200932..202479
                     /gene="mce1C"
                     /locus_tag="Rv0171"
                     /db_xref="GeneID:886808"
     CDS             200932..202479
                     /gene="mce1C"
                     /locus_tag="Rv0171"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="Mce family protein Mce1C"
                     /protein_id="NP_214685.1"
                     /db_xref="GeneID:886808"
                     /translation="MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYG
                     QFTDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNTIGTESRLAIRTDTI
                     LGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKAASGWDIETVKRSLNV
                     LSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITHLLAQANQVASILGDRSEQVDRLL
                     VNAKTLIAAFNERGRAVDALLGNISAFSAQVQNLINDNPNLNHVLEQLRILTDLLVDR
                     KEDLAETLTILGRFSASFGETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPED
                     FWRSAGLPAYRWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADGL
                     PRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAPGLPIAGRPGEVPPNVP
                     GTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGPPAPPGPGPQLPAPFINPGGTGGSG
                     VTGGSEN"
     misc_feature    200962..201810
                     /gene="mce1C"
                     /locus_tag="Rv0171"
                     /note="virulence factor Mce family protein; Region:
                     Mtu_fam_mce; TIGR00996"
                     /db_xref="CDD:273384"
     misc_feature    <202039..202341
                     /gene="mce1C"
                     /locus_tag="Rv0171"
                     /note="Epstein-Barr virus nuclear antigen 3 (EBNA-3);
                     Region: EBV-NA3; cl27975"
                     /db_xref="CDD:332796"
     gene            202476..204068
                     /gene="mce1D"
                     /locus_tag="Rv0172"
                     /db_xref="GeneID:886807"
     CDS             202476..204068
                     /gene="mce1D"
                     /locus_tag="Rv0172"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="Mce family protein Mce1D"
                     /protein_id="NP_214686.1"
                     /db_xref="GeneID:886807"
                     /translation="MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKL
                     TNNTVVAYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPANAS
                     AVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRDSVSHIIDELG
                     PTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALNALNEGRGDFFAVVRSLAL
                     FVNALHQDDQQFVALNKNLAEFTDRLTHSDADLSNAIQQFDSLLAVARPFFAKNREVL
                     THDVNNLATVTTTLLQPDPLDGLETVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFA
                     NPMEFICSSIQAGSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEI
                     AYSEPRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLTP
                     ESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPPPPPGPDVIP
                     GPVPPTPAPVGAPLPAEAGGGQ"
     misc_feature    202515..203411
                     /gene="mce1D"
                     /locus_tag="Rv0172"
                     /note="virulence factor Mce family protein; Region:
                     Mtu_fam_mce; TIGR00996"
                     /db_xref="CDD:273384"
     gene            204065..205237
                     /gene="lprK"
                     /locus_tag="Rv0173"
                     /gene_synonym="mce1E"
                     /db_xref="GeneID:886804"
     CDS             204065..205237
                     /gene="lprK"
                     /locus_tag="Rv0173"
                     /gene_synonym="mce1E"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00013"
                     /note="Mce family lipoprotein Mce1E"
                     /codon_start=1
                     /transl_table=11
                     /product="Mce family lipoprotein LprK"
                     /protein_id="NP_214687.1"
                     /db_xref="GeneID:886804"
                     /translation="MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGG
                     PGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLKKDVTL
                     PKNATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTIPLKRSSAYPTTEQTLASIAT
                     LLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNR
                     LLAYVGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDL
                     HQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYS
                     AIDNAFLTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC"
     misc_feature    204149..204994
                     /gene="lprK"
                     /locus_tag="Rv0173"
                     /gene_synonym="mce1E"
                     /note="virulence factor Mce family protein; Region:
                     Mtu_fam_mce; TIGR00996"
                     /db_xref="CDD:273384"
     gene            205231..206778
                     /gene="mce1F"
                     /locus_tag="Rv0174"
                     /db_xref="GeneID:886820"
     CDS             205231..206778
                     /gene="mce1F"
                     /locus_tag="Rv0174"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="Mce family protein Mce1F"
                     /protein_id="NP_214688.1"
                     /db_xref="GeneID:886820"
                     /translation="MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKA
                     DLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVHSVS
                     AVGEQYIDLVSTGAPGKYFSSGQTITKGTVPSEIGPALDNSNRGLAALPTEKIGLLLD
                     ETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERW
                     ARKLNNLAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLK
                     RYHAGVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSP
                     ADTSPRPLPSGTYCKIPQDAQLQVRGARNIPCVDVLGKRAATPKECRSKDPYVPLGTN
                     PWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQ
                     RPGSGTVQCNGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWK
                     EMLAPAS"
     misc_feature    205255..206112
                     /gene="mce1F"
                     /locus_tag="Rv0174"
                     /note="virulence factor Mce family protein; Region:
                     Mtu_fam_mce; TIGR00996"
                     /db_xref="CDD:273384"
     misc_feature    206098..>206679
                     /gene="mce1F"
                     /locus_tag="Rv0174"
                     /note="Atrophin-1 family; Region: Atrophin-1; cl26464"
                     /db_xref="CDD:331285"
     repeat_region   206812..206850
                     /note="39 bp direct repeat
                     1,AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG"
     gene            206814..207455
                     /locus_tag="Rv0175"
                     /db_xref="GeneID:886801"
     CDS             206814..207455
                     /locus_tag="Rv0175"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="Mce associated membrane protein"
                     /protein_id="NP_214689.3"
                     /db_xref="GeneID:886801"
                     /translation="MKAADSAESDAGADQTGPQVKAADSAESDAGELGEDACPEQALV
                     ERRPSRLRRGWLVGIAATLLALAGGLGAAGYFALRSHQESQSIAREDLAAIEAAKDCV
                     AATQAPDAGAMSASMQKIIECGTGDFGAQASLYTSMLVEAYQAASVHVQVTDMRAAVE
                     RNNNDGSVDVLVALRVKVSNTDSDAHEVGYRLRVRMALDEGRYKIAKLDQVTK"
     repeat_region   206869..206907
                     /locus_tag="Rv0175"
                     /note="39 bp direct repeat
                     2,AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG"
     gene            207452..208420
                     /locus_tag="Rv0176"
                     /db_xref="GeneID:886799"
     CDS             207452..208420
                     /locus_tag="Rv0176"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="Mce associated transmembrane protein"
                     /protein_id="NP_214690.1"
                     /db_xref="GeneID:886799"
                     /translation="MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATM
                     ALTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGS
                     AIGPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVI
                     RRLTAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPET
                     VQRDFERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFM
                     QGERGTPPNQRYIQSTVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK"
     misc_feature    207488..208069
                     /locus_tag="Rv0176"
                     /note="Uncharacterized membrane protein YckC, RDD family
                     [Function unknown]; Region: YckC; COG1714"
                     /db_xref="CDD:224628"
     gene            208417..208971
                     /locus_tag="Rv0177"
                     /db_xref="GeneID:886795"
     CDS             208417..208971
                     /locus_tag="Rv0177"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="Mce associated protein"
                     /protein_id="NP_214691.1"
                     /db_xref="GeneID:886795"
                     /translation="MSPRRKFEPGEGALLAPQSIEPSRRWGLPLALTASAVVMAAAIS
                     ACALMRISHESHQRAAHKDIVMLSDVRSFMTMFTSPDPFHANEYAERVLSHATGDFAK
                     QYHERANDILIRISGVEPTTGTVLDAGVQRWNEDGSANVLVVTQITSKSADGKRVVSN
                     ANRWLVTAKQEGNEWKISSLLPVI"
     gene            208938..209672
                     /locus_tag="Rv0178"
                     /db_xref="GeneID:886814"
     CDS             208938..209672
                     /locus_tag="Rv0178"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="Mce associated membrane protein"
                     /protein_id="NP_214692.1"
                     /db_xref="GeneID:886814"
                     /translation="MEDQQSASGDLTQKSVANGESTDTASAATEGHRGEIDAAGEPDE
                     RGAAVADSQADEDDSAATAARGGKTRARRSRGRRLAITVGVAAALFVGSAAFAGATVE
                     PYLSERAVVATKLMVARTAANAITTLWTYTPENMDTLADRAANYLSGDFAAQYRRFVD
                     QIAAANKQAKITNDTEVTGAAVESLSGRDAVAIVYTNTTTTSPVTKNIPALKYLSYRL
                     FMKRYDARWLVTRMTTITSLDLTPQV"
     gene            complement(209703..210812)
                     /gene="lprO"
                     /locus_tag="Rv0179c"
                     /db_xref="GeneID:886796"
     CDS             complement(209703..210812)
                     /gene="lprO"
                     /locus_tag="Rv0179c"
                     /inference="protein motif:PROSITE:PS00013"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein LprO"
                     /protein_id="NP_214693.1"
                     /db_xref="GeneID:886796"
                     /translation="MWIRAERVAVLTPTASLRRLTACYAALAVCAALACTTGQPAARA
                     ADGREMLAQAIATTRGSYLVYNFGGGHPMPLLNAGGHWYEMNNGGHLMIIKNASQRLS
                     PHLLVDTHTGDQARCEHNPGARTGEGLWQASEIYPPLKAWQRMGRPTIAVNANFFDVR
                     GQKGGSWRSTGCSSPLGAYVDNTRGQGRANQAVTGTVAYAGKQGLSGGNELWSSLTTM
                     ILPVGGAPYVLRPKSRQDYDLATPVIEDLLNKNARFVAVAGIGLLSPGNTGQLHDGGP
                     SAARTALAYAKQKDEMYIFQGGNYTPDNIQDLFRGLGSDTAILLDGGGSSAIVLRRDT
                     GGMWAGAGSPKGSCDTRQVLCDSHERALPSWLAFN"
     gene            complement(210892..212250)
                     /locus_tag="Rv0180c"
                     /db_xref="GeneID:886792"
     CDS             complement(210892..212250)
                     /locus_tag="Rv0180c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214694.1"
                     /db_xref="GeneID:886792"
                     /translation="MSQAQPRPAAPNPKRNVKAIRTVRFWMAPIATTLALMSALAALY
                     LGGILNPMTNLRHFPIALVNEDAGPAGQQIVDGLVSGLDKNKFDIRVVSPDEARRLLD
                     TAAVYGSALIPPTFSSQLRDFGASAVTPTRTDRPAITISTNPRAGTLAASIAGQTLTR
                     ALTVVNGKVGERLTAEVAAQTGGVALAGAAAAGLASPIDVKSTAYNPLPNGTGNGLSA
                     FYYALLLLLAGFTGSIVVSTLVDSMLGYVPAEFGPVYRFAEQVNISRFRTLLVKWAVM
                     VVLALLTSGVYLAIAHGLGMPIPLGWQVWLYGVFAIIAVGVTSSSLIAVLGSMGLLVS
                     MLIFVILGLPSAGATVPLEAVPAFFRWLAQFEPMHQVFLGVRSLLYLNGNADAGLSQA
                     LTMTSIGLIIGLLLGGFITHLYDRSSFHRIPGAVEMAIAVEHQAQYQARQSARESSSE
                     QP"
     misc_feature    complement(<210901..212220)
                     /locus_tag="Rv0180c"
                     /note="Uncharacterized membrane protein YhgE, phage
                     infection protein (PIP) family [Function unknown]; Region:
                     YhgE; COG1511"
                     /db_xref="CDD:224428"
     gene            complement(212277..213011)
                     /locus_tag="Rv0181c"
                     /db_xref="GeneID:886788"
     CDS             complement(212277..213011)
                     /locus_tag="Rv0181c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214695.1"
                     /db_xref="GeneID:886788"
                     /translation="MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLL
                     VNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGI
                     LHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAA
                     LTLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDAD
                     ARGLTANEPSEVLIWEMHAKLGDSAT"
     misc_feature    complement(212280..212996)
                     /locus_tag="Rv0181c"
                     /note="Redox-sensitive bicupin YhaK, pirin superfamily
                     [General function prediction only]; Region: YhaK; COG1741"
                     /db_xref="CDD:224655"
     gene            complement(213028..214140)
                     /gene="sigG"
                     /locus_tag="Rv0182c"
                     /db_xref="GeneID:886786"
     CDS             complement(213028..214140)
                     /gene="sigG"
                     /locus_tag="Rv0182c"
                     /experiment="EXISTENCE:Gene expression[PMID:16483748]"
                     /experiment="EXISTENCE:Gene expression[PMID:21169493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS01063"
                     /note="ECF type sigma factor"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF RNA polymerase sigma factor SigG"
                     /protein_id="NP_214696.1"
                     /db_xref="GeneID:886786"
                     /translation="MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAE
                     NSGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFA
                     GKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPD
                     VTDDPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTST
                     VAVNSLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTA
                     EAIWEMPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVH
                     LPFQLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL"
     misc_feature    complement(213031..213996)
                     /gene="sigG"
                     /locus_tag="Rv0182c"
                     /note="RNA polymerase factor sigma-70; Validated; Region:
                     PRK08241"
                     /db_xref="CDD:236196"
     gene            214088..214927
                     /locus_tag="Rv0183"
                     /db_xref="GeneID:886785"
     CDS             214088..214927
                     /locus_tag="Rv0183"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="lysophospholipase"
                     /protein_id="NP_214697.2"
                     /db_xref="GeneID:886785"
                     /translation="MTTTRTERNFAGIGDVRIVYDVWTPDTAPQAVVVLAHGLGEHAR
                     RYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLVGIATREYPGC
                     KRIVLGHSMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPG
                     LPVQELDFTAISRDPEVVQAYNTDPLVHHGRVPAGIGRALLQVGETMPRRAPALTAPL
                     LVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNEPERNQVLDDVVAWLT
                     ERL"
     misc_feature    214166..214876
                     /locus_tag="Rv0183"
                     /note="Serine aminopeptidase, S33; Region: Hydrolase_4;
                     pfam12146"
                     /db_xref="CDD:314939"
     gene            214969..215718
                     /locus_tag="Rv0184"
                     /db_xref="GeneID:886806"
     CDS             214969..215718
                     /locus_tag="Rv0184"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214698.1"
                     /db_xref="GeneID:886806"
                     /translation="MTNDKMLARIAALLRQAEGTDNPHEADAFMSTAQRLATAASIDL
                     AVARSHAGNRSPAQAPTQRTITIGAAGTRGLRTYVQLFVLIAAANDVRCDVASNSTFV
                     YAYGFAEDIDTSHALYASLVVQMVRASDAYLASGAHRPTPTITARLNFQLAFGARVGQ
                     RLADAREQTRQEATKDRDRPPGTAIALRDKDIELHEYYRRSSKARGAWRASRATAGYS
                     SAARRAGDRAGRQARLGNNPELPGARAALGR"
     misc_feature    214981..215097
                     /locus_tag="Rv0184"
                     /note="Protein of unknown function (DUF2786); Region:
                     DUF2786; pfam10979"
                     /db_xref="CDD:314021"
     gene            215715..216224
                     /locus_tag="Rv0185"
                     /db_xref="GeneID:886782"
     CDS             215715..216224
                     /locus_tag="Rv0185"
                     /inference="protein motif:PROSITE:PS00142"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214699.1"
                     /db_xref="GeneID:886782"
                     /translation="MIGADVPRDSQRARVYAAEAFVRTLFDRVTAHGSPTVEFFGTQL
                     TLPPEGRFGSVASVQRYVDDVLALPAVGQNWPTVSPVRVRARRAATAAHYENHGGTGT
                     IAVPDRHTAGWAMRELVVLHEVAHHLCQVPPPHGPEFVATVCTLTELVMGPEVGHVFR
                     VVYAQEGVR"
     misc_feature    215736..216218
                     /locus_tag="Rv0185"
                     /note="putative metallohydrolase, TIGR04338 family;
                     Region: HEXXH_Rv0185"
                     /db_xref="CDD:275137"
     gene            216269..218344
                     /gene="bglS"
                     /locus_tag="Rv0186"
                     /db_xref="GeneID:886780"
     CDS             216269..218344
                     /gene="bglS"
                     /locus_tag="Rv0186"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-glucosidase BglS"
                     /protein_id="NP_214700.1"
                     /db_xref="GeneID:886780"
                     /translation="MTDDERFSLLVGLTGASDLWPVRDERIPQGVPMCAGYVPGIPRL
                     GVPALLMSDAGLGVTNPGYRPGDTATALPAGLALAASFNPVLARSSGKAIGREARSRG
                     FNVQLAGAINLARDPRNGRNFEYLSEDPLLSATMAAESIIGIQQQGVIATTKHFSLNC
                     NETNRHWLDAVIDPDAHRESDLLAFEIVIERSQPGAVMAAYNKVNGDYAAGNDHLLND
                     VLKGAWGYRGWVMSDWGGTPSWECALAGLDQECGAQIDAVLWQSEAFTDRLRAAYADG
                     NLPKGRLSDMVRRILRSMFAVGIDRWKPAPAPDMNAHNEIAAQMARQGIVLLQNRGLL
                     PLAPESAGRIAVIGGYAHLGVPAGYGSSAVTPPGGYAGVIPIGGSGLAAGLRNLYLLP
                     SSPLSELRKRLPNAQFEFDPGINPAEAVLAARRADIAIVFAIRAEGEGFDSADLSLPW
                     GQDALIAAVASANANTVVVLETGNPVTMPWRDSVNAIMQAWYPGQAGGQAVAEIVTGQ
                     VNPSGRLPITFPVDLGQTPRSQPPELGAPWGTSTTIHYTEGADVGYRWFASTNQTPMF
                     AFGHGLSYTSFEYRDLVVTGGHTVHASFSVTNTGDRSGADVPQLYMIAAPGESRLRLL
                     GFERVELEPGQTRRVRIEADPRLLARYDGEARSWRIEPGGYTVAVGASAVALKLAAKV
                     KLAGRGFGR"
     misc_feature    216362..217420
                     /gene="bglS"
                     /locus_tag="Rv0186"
                     /note="Periplasmic beta-glucosidase and related
                     glycosidases [Carbohydrate transport and metabolism];
                     Region: BglX; COG1472"
                     /db_xref="CDD:224389"
     misc_feature    217241..217930
                     /gene="bglS"
                     /locus_tag="Rv0186"
                     /note="Glycosyl hydrolase family 3 C-terminal domain;
                     Region: Glyco_hydro_3_C; pfam01915"
                     /db_xref="CDD:307846"
     misc_feature    218084..218284
                     /gene="bglS"
                     /locus_tag="Rv0186"
                     /note="Fibronectin type III-like domain; Region: Fn3-like;
                     pfam14310"
                     /db_xref="CDD:316800"
     gene            complement(218390..218551)
                     /gene="mymT"
                     /locus_tag="Rv0186A"
                     /experiment="DESCRIPTION:Mutation analysis, protein
                     purification and characterization[PMID:18724363]"
                     /db_xref="GeneID:14515880"
     CDS             complement(218390..218551)
                     /gene="mymT"
                     /locus_tag="Rv0186A"
                     /experiment="DESCRIPTION:Mutation analysis, protein
                     purification and characterization[PMID:18724363]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallothionein"
                     /protein_id="YP_004837046.2"
                     /db_xref="GeneID:14515880"
                     /translation="MRVIRMTNYEAGTLLTCSHEGCGCRVRIEVPCHCAGAGDAYRCT
                     CGDELAPVK"
     gene            218705..219367
                     /locus_tag="Rv0187"
                     /db_xref="GeneID:886779"
     CDS             218705..219367
                     /locus_tag="Rv0187"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="NP_214701.1"
                     /db_xref="GeneID:886779"
                     /translation="MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAV
                     SAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVAR
                     VNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVAYIQWAIRLARRGA
                     VIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALAL
                     VR"
     misc_feature    218705..219364
                     /locus_tag="Rv0187"
                     /note="Predicted O-methyltransferase YrrM [General
                     function prediction only]; Region: YrrM; COG4122"
                     /db_xref="CDD:226607"
     gene            219486..219917
                     /locus_tag="Rv0188"
                     /db_xref="GeneID:886776"
     CDS             219486..219917
                     /locus_tag="Rv0188"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214702.1"
                     /db_xref="GeneID:886776"
                     /translation="MSTVHSSIDQHPDLLALRASFDRAAESTIAHFTFGLALLAGLYV
                     AASPWIVGFSATRGLPTCDLIVGIAVAYLAYGFASALDRTHGMTWTLPVLGVWVIFSP
                     WVLPGVAVTAGMMWSHIIAGAVVAVLGFYFGMRTRAAANQG"
     misc_feature    219588..219725
                     /locus_tag="Rv0188"
                     /note="SPW repeat; Region: SPW; pfam03779"
                     /db_xref="CDD:309052"
     misc_feature    219750..219893
                     /locus_tag="Rv0188"
                     /note="SPW repeat; Region: SPW; pfam03779"
                     /db_xref="CDD:309052"
     gene            complement(219996..221723)
                     /gene="ilvD"
                     /locus_tag="Rv0189c"
                     /db_xref="GeneID:886774"
     CDS             complement(219996..221723)
                     /gene="ilvD"
                     /locus_tag="Rv0189c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00886"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="NP_214703.1"
                     /db_xref="GeneID:886774"
                     /translation="MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDD
                     EDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGYPLEFGTISVSDGISMGH
                     EGMHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYA
                     GSILPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGACGGMY
                     TANTMASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEA
                     FENAIAVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVM
                     SDVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPI
                     HPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAALDALEDGTITVGDAV
                     VIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHIAPEAVD
                     GGPIALLRNGDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVS
                     SAAVGAVCG"
     misc_feature    complement(220002..221669)
                     /gene="ilvD"
                     /locus_tag="Rv0189c"
                     /note="dihydroxy-acid dehydratase; Provisional; Region:
                     PRK00911"
                     /db_xref="CDD:234861"
     gene            221871..222161
                     /locus_tag="Rv0190"
                     /db_xref="GeneID:886772"
     CDS             221871..222161
                     /locus_tag="Rv0190"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214704.1"
                     /db_xref="GeneID:886772"
                     /translation="MTAAHGYTQQKDNYAKRLRRVEGQVRGIARMIEEDKYCIDVLTQ
                     ISAVTSALRSVALNLLDEHLSHCVTRAVAEGGPGADGKLAEASAAIARLVRS"
     misc_feature    221880..222152
                     /locus_tag="Rv0190"
                     /note="DNA-binding transcriptional regulator, FrmR family
                     [Transcription]; Region: FrmR; COG1937"
                     /db_xref="CDD:224848"
     misc_feature    order(221901..221903,221910..221915,221922..221927,
                     221934..221936,221943..221948,221952..221957,
                     221964..221975,221979..221987,221991..221999,
                     222003..222008,222012..222017,222024..222029,
                     222036..222041,222045..222053,222057..222065,
                     222072..222074,222105..222110,222114..222143)
                     /locus_tag="Rv0190"
                     /note="putative homotetramer interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:197385"
     misc_feature    order(221901..221903,221910..221915,221922..221927,
                     221934..221936,221943..221948,221952..221957,
                     221964..221975,221979..221987,221991..221999,
                     222003..222008,222012..222017,222024..222029,
                     222036..222038,222045..222047,222057..222059,
                     222123..222125,222132..222143)
                     /locus_tag="Rv0190"
                     /note="putative homodimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:197385"
     misc_feature    order(221979..221981,222057..222059,222123..222125)
                     /locus_tag="Rv0190"
                     /note="putative allosteric switch controlling residues;
                     other site"
                     /db_xref="CDD:197385"
     misc_feature    order(221982..221984,222057..222059,222069..222071)
                     /locus_tag="Rv0190"
                     /note="putative metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:197385"
     misc_feature    order(222039..222041,222048..222053,222060..222065,
                     222069..222074,222105..222110,222114..222122,
                     222126..222131)
                     /locus_tag="Rv0190"
                     /note="putative homodimer-homodimer interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:197385"
     gene            222289..223530
                     /locus_tag="Rv0191"
                     /db_xref="GeneID:886770"
     CDS             222289..223530
                     /locus_tag="Rv0191"
                     /note="integral membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS-type transporter"
                     /protein_id="NP_214705.1"
                     /db_xref="GeneID:886770"
                     /translation="MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGAL
                     SAIARNLRVSVVLVGTLLSWYALVAAVTTVPLVRWTAHWPRRRALVVSLVCLTVSQLV
                     SALAPNFAVLAAGRVLCAVTHGLLWAVIAPIATRLVPPSHAGRATTSIYIGTSLALVV
                     GSPLTAAMSLMWGWRLAAVCVTGAAAAVALAARLALPEMVLRADQLEHVGRRARHHRN
                     PRLVKVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLLAAYGVAGLVSVPLVA
                     RPLDRWPKGAVIVGMTGLTAAFTLLTALAFGERHTAATALLGTGAIVLWGALATAVSP
                     MLQSAAMRSGGDDPDGASGLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVA
                     LFGMTVSQHLFENPTLSPGDG"
     misc_feature    222313..223515
                     /locus_tag="Rv0191"
                     /note="Predicted arabinose efflux permease, MFS family
                     [Carbohydrate transport and metabolism]; Region: AraJ;
                     COG2814"
                     /db_xref="CDD:225371"
     gene            223564..224664
                     /locus_tag="Rv0192"
                     /db_xref="GeneID:886768"
     CDS             223564..224664
                     /locus_tag="Rv0192"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214706.1"
                     /db_xref="GeneID:886768"
                     /translation="MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGC
                     WRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDP
                     LAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVP
                     IADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRT
                     GDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDS
                     STYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAK
                     WFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI"
     misc_feature    223942..224226
                     /locus_tag="Rv0192"
                     /note="IgD-like repeat domain of mycobacterial
                     L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431"
                     /db_xref="CDD:240446"
     misc_feature    223969..224619
                     /locus_tag="Rv0192"
                     /note="Lipoprotein-anchoring transpeptidase ErfK/SrfK
                     [Cell wall/membrane/envelope biogenesis]; Region: ErfK;
                     COG1376"
                     /db_xref="CDD:224294"
     gene            complement(224724..226571)
                     /locus_tag="Rv0193c"
                     /db_xref="GeneID:886764"
     CDS             complement(224724..226571)
                     /locus_tag="Rv0193c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214707.1"
                     /db_xref="GeneID:886764"
                     /translation="MIQISRDMSSLGQTATTQALPDNSDGIQLTKFAADDILPLEYAP
                     PIGPELVSQDQLPAAWAYKRFRDLDDKESYRRKLLQELTDALAAQGSEAAEIATAALR
                     DLIDQMAEQGAVVLADIVESDDFLELVKRYDELMAREGSRSFIHRFLDLRRSPGMLTD
                     PAVNGALVHPLMIALISYAVGGPIRMIDARGKDAEPLSVLAQDNMLHIDNTPFNDEYK
                     ILITWRRGTAQGPAGQNFTFLPGTHKLARTCFVNEDGVPWSSENASIFTTPDSIRKVF
                     DAQRQLGGQDHPTVIEVTDSERPLSGVFAAGSLVHHRFRTASGSARSCIILVFHRVAD
                     NPGRMVSDVEDSSDVSLSELLTRGVPDESYQQRFIATLCAAADEIAELLLKWKKTPQR
                     PVSLPLQTKQIDGARFEEWISAATKAPEVREIRNRELTIPYGEVLSAEEFFDLIWRLM
                     RFDKHGPLDLILYHDNREEPRKWARNLIREMSADRLYERLLGWLADIQQPRPADCLRP
                     LQIHALISEVLKTLPLDEDQDPPADWHFDLLGMSHAEAARSVKHLLEDVAEALLRCED
                     MAAYLSTSLFAFWAVDAAYSLDGRRNLVVKDCARRLLRHYTMLSLTCFQ"
     gene            226878..230462
                     /locus_tag="Rv0194"
                     /db_xref="GeneID:886790"
     CDS             226878..230462
                     /locus_tag="Rv0194"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00211"
                     /note="Belongs to the ATP-binding transport protein family
                     (ABC transporters)."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug ABC transporter ATPase/permease"
                     /protein_id="NP_214708.1"
                     /db_xref="GeneID:886790"
                     /translation="MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRV
                     IDDAIAADHRPLAPWAVVLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLR
                     WDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAVMTWLSVPLAL
                     LAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERET
                     VKLVTASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFV
                     AFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEARLSL
                     EFQRVSFGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVR
                     IGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIE
                     EFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECG
                     IQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRYRELL
                     SPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTNVHNPGPHDHPPGPDPLRRLLREFR
                     GPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIRWVVQ
                     WGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLR
                     TGLVVAVISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARH
                     RLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVA
                     LLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVA
                     AGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTV
                     VFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFA
                     GTVRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLL
                     ALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADR
                     IVVLEHGTVVEDGAHTELLAAGGHYSRLWAAHTRLCSPEITQLQCIDA"
     misc_feature    226893..228572
                     /locus_tag="Rv0194"
                     /note="ABC-type multidrug transport system, ATPase and
                     permease component [Defense mechanisms]; Region: MdlB;
                     COG1132"
                     /db_xref="CDD:224055"
     misc_feature    228786..230414
                     /locus_tag="Rv0194"
                     /note="ABC-type multidrug transport system, ATPase and
                     permease component [Defense mechanisms]; Region: MdlB;
                     COG1132"
                     /db_xref="CDD:224055"
     gene            230899..231534
                     /locus_tag="Rv0195"
                     /db_xref="GeneID:886762"
     CDS             230899..231534
                     /locus_tag="Rv0195"
                     /codon_start=1
                     /transl_table=11
                     /product="two component transcriptional regulator"
                     /protein_id="NP_214709.1"
                     /db_xref="GeneID:886762"
                     /translation="MAPVNVISVAVVASDPLTRDGALARLSSHRELDVRAWQAGCETS
                     VLLVLATTITAPLLCQIEDVQKDGPSHAPKLVVVADEFSAEQVFRMIKLGLTGLLYRS
                     QSTFDCIVETIRLSAEGRLRLPERVQRYLVGRIKSTPTAEPDTPCAAALAEREVAVLR
                     LLADGLSTHQVAVQLNYCERTIKNIVHDIVTRLKLRNRTHAVAHALRAGLI"
     misc_feature    230917..231531
                     /locus_tag="Rv0195"
                     /note="DNA-binding response regulator, NarL/FixJ family,
                     contains REC and HTH domains [Signal transduction
                     mechanisms, Transcription]; Region: CitB; COG2197"
                     /db_xref="CDD:225107"
     gene            231647..232231
                     /locus_tag="Rv0196"
                     /db_xref="GeneID:886760"
     CDS             231647..232231
                     /locus_tag="Rv0196"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_214710.1"
                     /db_xref="GeneID:886760"
                     /translation="MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYF
                     PGGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAV
                     SVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEG
                     AILLARVRRDLTPLDLVHRQLRNLLLAELPERSR"
     misc_feature    231659..232165
                     /locus_tag="Rv0196"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            232231..234519
                     /locus_tag="Rv0197"
                     /db_xref="GeneID:886758"
     CDS             232231..234519
                     /locus_tag="Rv0197"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214711.1"
                     /db_xref="GeneID:886758"
                     /translation="MTSSDWLPTACILCECNCGIVVQVDDRRLARIRGDKAHPGSAGY
                     TCNKALRLDHYQNNRARLSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKI
                     FYYGGGGQGNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGGHTRGEFEN
                     AEVSVFVGKNPWMSQSFPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPG
                     CDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELLR
                     AAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQHLHSSFAPL
                     FSQVSGRTPVTGAPIIAGLIPGNVVPEEILTEHPDRFRAMIVERGNPAHSLADSAACR
                     AAFQALELMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFP
                     PLPGTLPEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVAKL
                     TAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNALFDAILERPS
                     GVTFTVHNYEDDFALISHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGER
                     RAYTANDIFRDPSWRKRDANGALRVSVEDAQALGLADGCLARITTAAGSAEATVEVTE
                     TMLAGHAALPNGFGLDYTGDDGRTVVAGVAPNALTSTRWRDPYAGTPWHKHVPAAIRR
                     ADAESPIWYPKWAILPARGVLA"
     misc_feature    232231..234456
                     /locus_tag="Rv0197"
                     /note="Anaerobic selenocysteine-containing dehydrogenase
                     [Energy production and conversion]; Region: BisC; COG0243"
                     /db_xref="CDD:223321"
     misc_feature    232252..234039
                     /locus_tag="Rv0197"
                     /note="The MopB_1 CD includes a group of related
                     uncharacterized bacterial molybdopterin-binding
                     oxidoreductase-like domains with a putative N-terminal
                     iron-sulfur [4Fe-4S] cluster binding site and
                     molybdopterin cofactor binding site. These members belong
                     to...; Region: MopB_1; cd02762"
                     /db_xref="CDD:239163"
     misc_feature    order(232261..232263,232270..232272,232282..232284,
                     232366..232368)
                     /locus_tag="Rv0197"
                     /note="putative [Fe4-S4] binding site [ion binding]; other
                     site"
                     /db_xref="CDD:239163"
     misc_feature    order(232372..232374,232618..232620,232624..232632,
                     232729..232734,232738..232740,232747..232752,
                     232822..232830,232888..232890,233107..233118,
                     233221..233226,233362..233370,233440..233448,
                     233455..233457,233491..233496,233509..233511)
                     /locus_tag="Rv0197"
                     /note="putative molybdopterin cofactor binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:239163"
     misc_feature    234070..234453
                     /locus_tag="Rv0197"
                     /note="The MopB_CT_1 CD includes a group of related
                     uncharacterized bacterial molybdopterin-binding
                     oxidoreductase-like domains with a putative N-terminal
                     iron-sulfur [4Fe-4S] cluster binding site and
                     molybdopterin cofactor binding site. This CD is of the...;
                     Region: MopB_CT_1; cd02782"
                     /db_xref="CDD:239183"
     misc_feature    order(234091..234105,234109..234120,234307..234309,
                     234370..234372,234430..234435)
                     /locus_tag="Rv0197"
                     /note="putative molybdopterin cofactor binding site; other
                     site"
                     /db_xref="CDD:239183"
     gene            complement(234516..236507)
                     /gene="zmp1"
                     /locus_tag="Rv0198c"
                     /db_xref="GeneID:886755"
     CDS             complement(234516..236507)
                     /gene="zmp1"
                     /locus_tag="Rv0198c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00142"
                     /note="belongs to peptidase family M13 (zinc
                     metalloprotease); also known as the neprilysin subfamily."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease"
                     /protein_id="NP_214712.1"
                     /db_xref="GeneID:886755"
                     /translation="MTLAIPSGIDLSHIDADARPQDDLFGHVNGRWLAEHEIPADRAT
                     DGAFRSLFDRAETQVRDLIIQASQAGAAVGTDAQRIGDLYASFLDEEAVERAGVQPLH
                     DELATIDSAADATELAAALGTLQRAGVGGGIGVYVDTDSKDSTRYLVHFTQSGIGLPD
                     ESYYRDEQHAAVLAAYPGHIARMFGLVYGGESRDHAKTADRIVALETKLADAHWDVVK
                     RRDADLGYNLRTFAQLQTEGAGFDWVSWVTALGSAPDAMTELVVRQPDYLVTFASLWA
                     SVNVEDWKCWARWRLIRARAPWLTRALVAEDFEFYGRTLTGAQQLRDRWKRGVSLVEN
                     LMGDAVGKLYVQRHFPPDAKSRIDTLVDNLQEAYRISISELDWMTPQTRQRALAKLNK
                     FTAKVGYPIKWRDYSKLAIDRDDLYGNVQRGYAVNHDRELAKLFGPVDRDEWFMTPQT
                     VNAYYNPGMNEIVFPAAILQPPFFDPQADEAANYGGIGAVIGHEIGHGFDDQGAKYDG
                     DGNLVDWWTDDDRTEFAARTKALIEQYHAYTPRDLVDHPGPPHVQGAFTIGENIGDLG
                     GLSIALLAYQLSLNGNPAPVIDGLTGMQRVFFGWAQIWRTKSRAAEAIRRLAVDPHSP
                     PEFRCNGVVRNVDAFYQAFDVTEDDALFLDPQRRVRIWN"
     misc_feature    complement(234522..236507)
                     /gene="zmp1"
                     /locus_tag="Rv0198c"
                     /note="Predicted metalloendopeptidase [Posttranslational
                     modification, protein turnover, chaperones]; Region: PepO;
                     COG3590"
                     /db_xref="CDD:226118"
     gene            236550..237209
                     /locus_tag="Rv0199"
                     /db_xref="GeneID:886753"
     CDS             236550..237209
                     /locus_tag="Rv0199"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214713.1"
                     /db_xref="GeneID:886753"
                     /translation="MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGI
                     ASTLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDAS
                     LQRLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAAR
                     PVVTTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESI
                     R"
     gene            237206..237895
                     /locus_tag="Rv0200"
                     /db_xref="GeneID:886803"
     CDS             237206..237895
                     /locus_tag="Rv0200"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214714.1"
                     /db_xref="GeneID:886803"
                     /translation="MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVL
                     LVVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRD
                     FNRDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLA
                     RRGVTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGW
                     LVLDVTPINAR"
     gene            complement(237892..238395)
                     /locus_tag="Rv0201c"
                     /db_xref="GeneID:886756"
     CDS             complement(237892..238395)
                     /locus_tag="Rv0201c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214715.1"
                     /db_xref="GeneID:886756"
                     /translation="MTLAAEPHPAPPQQPTVAWSEPDVDRRVEFWPTVAIRSALESGD
                     IATWQRIAAALKRDPYGRTARQVEEVLEGIPATGIANAFWEVLDRARTHLDANERAEV
                     ARQVGLLLDRSGLQRQEFASRIGVTAQDLTAYLDGIVSPSASLMIRMRRLSDRFVRAK
                     SVRAADS"
     gene            complement(238392..241292)
                     /gene="mmpL11"
                     /locus_tag="Rv0202c"
                     /db_xref="GeneID:886750"
     CDS             complement(238392..241292)
                     /gene="mmpL11"
                     /locus_tag="Rv0202c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane transport protein MmpL11"
                     /protein_id="NP_214716.1"
                     /db_xref="GeneID:886750"
                     /translation="MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEV
                     AGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTE
                     APNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYV
                     IGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITM
                     GLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMA
                     TSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFA
                     RAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVL
                     GNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRH
                     RIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQV
                     DVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAA
                     AYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQ
                     TGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATV
                     VRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPP
                     SADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWG
                     QRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDR
                     LQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPG
                     RQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR"
     misc_feature    complement(238599..241292)
                     /gene="mmpL11"
                     /locus_tag="Rv0202c"
                     /note="Uncharacterized membrane protein YdfJ, MMPL/SSD
                     domain [Function unknown]; Region: YdfJ; COG2409"
                     /db_xref="CDD:225272"
     gene            241514..241924
                     /locus_tag="Rv0203"
                     /db_xref="GeneID:886748"
     CDS             241514..241924
                     /locus_tag="Rv0203"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214717.1"
                     /db_xref="GeneID:886748"
                     /translation="MKTGTATTRRRLLAVLIALALPGAAVALLAEPSATGASDPCAAS
                     EVARTVGSVAKSMGDYLDSHPETNQVMTAVLQQQVGPGSVASLKAHFEANPKVASDLH
                     ALSQPLTDLSTRCSLPISGLQAIGLMQAVQGARR"
     misc_feature    241577..241897
                     /locus_tag="Rv0203"
                     /note="hemophore, mycobacterial-type; Region:
                     hemophoreRv0203; TIGR04530"
                     /db_xref="CDD:275323"
     gene            complement(241976..243214)
                     /locus_tag="Rv0204c"
                     /db_xref="GeneID:886747"
     CDS             complement(241976..243214)
                     /locus_tag="Rv0204c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214718.2"
                     /db_xref="GeneID:886747"
                     /translation="MSHDAPARNLRQRVGALPRTRVGAPPAEGVPPRGKYWWLRWAVL
                     AIVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGASMHSFAQIQRTLLKSA
                     GVHVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGASTVVASWQLVMSGVL
                     QAVGLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVASRPELIEGIGRRVLS
                     WANSVRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLFNWIADVACLGFAAYA
                     AGDHASVGGLAVAYAAARAVGTIPLMPGGLLVVEAVLVPGLVSSGMPLPSAISAMLIY
                     RLISWLLIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLVIQPQGTPCDDPVETT
                     PQGPAPTPDLRPEGGETPPR"
     misc_feature    complement(242123..243121)
                     /locus_tag="Rv0204c"
                     /note="Uncharacterized membrane protein YbhN, UPF0104
                     family [Function unknown]; Region: AglD2; COG0392"
                     /db_xref="CDD:223469"
     gene            243384..244487
                     /locus_tag="Rv0205"
                     /db_xref="GeneID:886766"
     CDS             243384..244487
                     /locus_tag="Rv0205"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214719.1"
                     /db_xref="GeneID:886766"
                     /translation="MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNKFEVI
                     VVPVLLALMLSALLVPPVDWLDSRGLPHAVAVTLVLLSGFAVLGGILTFVVSQFIAGL
                     PHLVTEVERSIDSARRWLIEGPAHLRGEQIDNAGNAAIEALRNNQAKLTSGALSTAAT
                     ITELVTAAVLVLFTLIFFLYGGRSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARA
                     TFLVALTDAAGVGAGLAVMGVPLALPLASLVFFGAFIPLIGAVVAGFLAVVVALLAKG
                     IGYALITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGALLAV
                     PTVAFFNNAVQVLLGGNPFADVADVSSDHLTEV"
     misc_feature    243447..244427
                     /locus_tag="Rv0205"
                     /note="AI-2E family transporter; Region: AI-2E_transport;
                     pfam01594"
                     /db_xref="CDD:279875"
     gene            complement(244484..247318)
                     /gene="mmpL3"
                     /locus_tag="Rv0206c"
                     /db_xref="GeneID:886752"
     CDS             complement(244484..247318)
                     /gene="mmpL3"
                     /locus_tag="Rv0206c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane transport protein MmpL3"
                     /protein_id="NP_214720.1"
                     /db_xref="GeneID:886752"
                     /translation="MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFY
                     DDGSQSVQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQDHP
                     DQVLGWAGYLRASQATGMATADKKYTFVSIPLKGDDDDTILNNYKAIAPDLQRLDGGT
                     VKLAGLQPVAEALTGTIATDQRRMEVLALPLVAVVLFFVFGGVIAAGLPVMVGGLCIA
                     GALGIMRFLAIFGPVHYFAQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRR
                     TVITAGRTVTFSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLG
                     ILGKHVDALGVRTLFRVPFLANWKISAAYLNWLADRLQRTKTREEVEAGFWGKLVNRV
                     MKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPTNSVRQAQEEFDKLFPGYRTN
                     PLTLVIQTSNHQPVTDAQIADIRSKAMAIGGFIEPDNDPANMWQERAYAVGASKDPSV
                     RVLQNGLINPADASKKLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVIL
                     LTTTIVLMFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLTA
                     PVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRIITAAALIVA
                     VVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVMKLLGDDCWWAPRWARRL
                     QTRIGLGEIHLPDERKRPVSNGRPARPPVTAGLVAARAAGDPRPPHDPTHPLAESPRP
                     ARSSPASSPELTPALEATAAPAAPSGASTTRMQIGSSTEPPTTRLAAAGRSVQSPAST
                     PPPTPTPPSAPSAGQTRAMPLAANRSTDAAGDPAEPTAALPIIRSDGDDSEAATEQLN
                     ARGTSDKTRQRRRGGGALSAQDLLRREGRL"
     misc_feature    complement(244943..247318)
                     /gene="mmpL3"
                     /locus_tag="Rv0206c"
                     /note="Uncharacterized membrane protein YdfJ, MMPL/SSD
                     domain [Function unknown]; Region: YdfJ; COG2409"
                     /db_xref="CDD:225272"
     misc_feature    complement(<244493..>245047)
                     /gene="mmpL3"
                     /locus_tag="Rv0206c"
                     /note="DNA polymerase III subunits gamma and tau domain
                     III; Region: DNA_pol3_gamma3; cl26386"
                     /db_xref="CDD:331207"
     gene            complement(247384..248112)
                     /locus_tag="Rv0207c"
                     /db_xref="GeneID:886742"
     CDS             complement(247384..248112)
                     /locus_tag="Rv0207c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:14532352]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214721.1"
                     /db_xref="GeneID:886742"
                     /translation="MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVW
                     DAPNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNI
                     APGSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASA
                     DGQAFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGL
                     DSLPEQGAWLQPFRPLSSLLTSRV"
     misc_feature    complement(247510..247995)
                     /locus_tag="Rv0207c"
                     /note="LabA_like proteins; Region: LabA_like; cd06167"
                     /db_xref="CDD:199895"
     misc_feature    complement(order(247624..247626,247630..247632,
                     247636..247638,247702..247704,247969..247971,
                     247978..247980))
                     /locus_tag="Rv0207c"
                     /note="putative metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:199895"
     gene            complement(248115..248906)
                     /locus_tag="Rv0208c"
                     /db_xref="GeneID:886740"
     CDS             complement(248115..248906)
                     /locus_tag="Rv0208c"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanine-N(7)-)-methyltransferase"
                     /protein_id="NP_214722.1"
                     /db_xref="GeneID:886740"
                     /translation="MVHHGQMHAQPGVGLRPDTPVASGQLPSTSIRSRRSGISKAQRE
                     TWERLWPELGLLALPQSPRGTPVDTRAWFGRDAPVVLEIGSGSGTSTLAMAKAEPHVD
                     VIAVDVYRRGLAQLLCAIDKVGSDGINIRLILGNAVDVLQHLIAPDSLCGVRVFFPDP
                     WPKARHHKRRLLQPATMALIADRLVPSGVLHAATDHPGYAEHIAAAGDAEPRLVRVDP
                     DTELLPISVVRPATKYERKAQLGGGAVIELLWKKHGCSERDLKIR"
     misc_feature    complement(248142..248831)
                     /locus_tag="Rv0208c"
                     /note="tRNA G46 methylase TrmB [Translation, ribosomal
                     structure and biogenesis]; Region: TrmB; COG0220"
                     /db_xref="CDD:223298"
     gene            249038..250123
                     /locus_tag="Rv0209"
                     /db_xref="GeneID:886739"
     CDS             249038..250123
                     /locus_tag="Rv0209"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214723.1"
                     /db_xref="GeneID:886739"
                     /translation="MRGQGHQIFVDELARFATSSADQRVVAIAQRAAEPLRVAVRGRP
                     GVGCRTVARALQGAGSSSGMTVTPQARAADSDVDLVVYVTVEVVKPEDREAIAATRRP
                     VVAVLNKADLAGPLSGAGPIVMAQARCAQFSTLLGVPMESMIGLLAVAALDDLDDTLR
                     AVLRALAAHPDGFDALDRAVAGFLAAALPVPTEVRLRLLDTLDLFGIALGMAAFRPGR
                     PSRTPAQLRTLLRRVSGVDAVIDKVTAAGSEVRYRRLLDAVAELEALAAQAKEIGGPI
                     GEFLRDDDTVLARMAAAVDVALAVGLDVGPLDDPAAHLPRAVRWHRYSLDNGDMHRTC
                     GADIARGSLRLWSLAGGMPLHRYRKSS"
     gene            250120..251598
                     /locus_tag="Rv0210"
                     /db_xref="GeneID:886735"
     CDS             250120..251598
                     /locus_tag="Rv0210"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214724.1"
                     /db_xref="GeneID:886735"
                     /translation="MIRAASDDPAGVDELVAAIAPGLAGLGLPVINRREVVLVTGPWL
                     AGVSGVRAALAERLPQRRFVETAELGPGDAPVAVVFVVSAATALTESDCVLLDTAAEH
                     TDAVVAVVSKIDVHRGWRDVLTSNRDRLAARASRYARVPWVGAAAAPELGEPYLDDLV
                     AAIQKQLADPAVARRNMLRAWESRLLMVARRFDGDAQSAGRRARVDALRQQRRTVLRQ
                     GRQSKSEHTIALRAQIQHARVKLSYFARNRCSLLRVELQEHVAGLSRKDIARFAAYTR
                     GRVQEVVAEVGEGAVAHLADVAQLLGVPVQPPVLENLPAVLPTVVAPPLTSRRLEIRL
                     TTLLGAGFGLGIALTLSRLVAGLTPGLAASGMVAGVAIGLAVTAWVVNARALLHDRVV
                     VDRWTGEVTASLRSVVEQLVATRVVAVETLLSTAISERDDAENARVADQVSIIDGELR
                     EHAVAAARAAALRDREMPAVRAALEAVRAELGEPGAPTTGLF"
     gene            251782..253602
                     /gene="pckA"
                     /locus_tag="Rv0211"
                     /gene_synonym="pck1; pckG"
                     /db_xref="GeneID:886744"
     CDS             251782..253602
                     /gene="pckA"
                     /locus_tag="Rv0211"
                     /gene_synonym="pck1; pckG"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00505"
                     /note="iron-regulated, alternate gene names: pckG and
                     pck1"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxykinase"
                     /protein_id="NP_214725.1"
                     /db_xref="GeneID:886744"
                     /translation="MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEE
                     FQRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNW
                     MDPGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMT
                     RMGKAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGS
                     GYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKT
                     NLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMR
                     TIAAGNTVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCT
                     PMSQCPILAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSEQTA
                     AAEGKVGNVRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDG
                     RFLWPGFGENSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALA
                     VDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDALKERLG"
     misc_feature    251800..253599
                     /gene="pckA"
                     /locus_tag="Rv0211"
                     /gene_synonym="pck1; pckG"
                     /note="phosphoenolpyruvate carboxykinase; Provisional;
                     Region: PRK04210"
                     /db_xref="CDD:235256"
     misc_feature    order(252022..252024,252439..252441,252445..252447,
                     252463..252468,252526..252528,252592..252612,
                     252664..252669,252733..252735,252739..252741,
                     252766..252768,252946..252948,253315..253317,
                     253324..253326,253333..253335)
                     /gene="pckA"
                     /locus_tag="Rv0211"
                     /gene_synonym="pck1; pckG"
                     /note="active site"
                     /db_xref="CDD:238417"
     misc_feature    order(252022..252024,252439..252441,252445..252447,
                     252463..252468,252733..252735,252946..252948)
                     /gene="pckA"
                     /locus_tag="Rv0211"
                     /gene_synonym="pck1; pckG"
                     /note="substrate-binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238417"
     misc_feature    order(252466..252468,252526..252528,252607..252609,
                     252664..252669,252733..252735)
                     /gene="pckA"
                     /locus_tag="Rv0211"
                     /gene_synonym="pck1; pckG"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238417"
     misc_feature    order(252595..252597,252601..252603,253039..253041,
                     253282..253287,253315..253317,253324..253326,
                     253333..253335)
                     /gene="pckA"
                     /locus_tag="Rv0211"
                     /gene_synonym="pck1; pckG"
                     /note="GTP binding site [chemical binding]; other site"
                     /db_xref="CDD:238417"
     gene            complement(253669..254640)
                     /gene="nadR"
                     /locus_tag="Rv0212c"
                     /gene_synonym="nadI"
                     /db_xref="GeneID:886734"
     CDS             complement(253669..254640)
                     /gene="nadR"
                     /locus_tag="Rv0212c"
                     /gene_synonym="nadI"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator NadR"
                     /protein_id="NP_214726.1"
                     /db_xref="GeneID:886734"
                     /translation="MTHGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAEPIP
                     GAQRVAWMRELFPFDRVVHLANENPQRPWEHPDFWDIWKASLQGVLATRPDFVFGAEP
                     YNADFAQVLGARFVAVDHGRTVVPVTATDIRADPLGHWQHIPRCVRPAFVKRVSIIGP
                     ESTGKTTLAQAVAEKLRTKWVPERAKMLRELNGGSLIGLEWAEIVRGQIASEEALARD
                     ADRVLICDTDPLATTVWAEFLAGGCPQELRDLARRPYDLTLLTTPDVPWDADDGRCVP
                     GARGTFFARCEQALRAAGRSFVVITGGWEERLSVSLRAVEELVRARR"
     misc_feature    complement(253717..254640)
                     /gene="nadR"
                     /locus_tag="Rv0212c"
                     /gene_synonym="nadI"
                     /note="bifunctional DNA-binding transcriptional repressor/
                     NMN adenylyltransferase; Provisional; Region: PRK08099;
                     cl28365"
                     /db_xref="CDD:333185"
     gene            complement(254637..255950)
                     /locus_tag="Rv0213c"
                     /db_xref="GeneID:886746"
     CDS             complement(254637..255950)
                     /locus_tag="Rv0213c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase"
                     /protein_id="NP_214727.1"
                     /db_xref="GeneID:886746"
                     /translation="MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTP
                     RLVGFSCIDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD
                     GEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVL
                     ADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNF
                     LSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGL
                     RRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDE
                     LRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEAS
                     RVYADVVAKVAPDVGISFDEAEAYFLSRLDEWENVIAGRIAEATS"
     misc_feature    complement(254682..255815)
                     /locus_tag="Rv0213c"
                     /note="Radical SAM superfamily enzyme YgiQ, UPF0313 family
                     [General function prediction only]; Region: YgiQ; COG1032"
                     /db_xref="CDD:223963"
     gene            256064..257677
                     /gene="fadD4"
                     /locus_tag="Rv0214"
                     /db_xref="GeneID:886737"
     CDS             256064..257677
                     /gene="fadD4"
                     /locus_tag="Rv0214"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00455"
                     /codon_start=1
                     /transl_table=11
                     /product="fatty-acid--CoA ligase FadD4"
                     /protein_id="NP_214728.1"
                     /db_xref="GeneID:886737"
                     /translation="MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKP
                     AVILYPSGTVISFDELEARANRLAHWFRQAGLREDDVVAILMENNEHVHAVMWAARRS
                     GLYYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGG
                     GLVGWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMM
                     PALLDFWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYR
                     VTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIHAAAPCPVQIKEQMIHWWGPIIDE
                     YYASSEASGSTLITAEDWLTHPGSVGKPIQGGVHIVGADGSELPPNQPGEIYFEGGYP
                     FEYLNDPAKTAASRNKHGWVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAEN
                     LLVAHPKVLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKC
                     PRSIAFEPQLPRTDTGKLYKSGLVEKYSV"
     misc_feature    256193..257668
                     /gene="fadD4"
                     /locus_tag="Rv0214"
                     /note="long-chain-fatty-acid--CoA ligase; Validated;
                     Region: PRK08276"
                     /db_xref="CDD:236215"
     gene            complement(257719..258856)
                     /locus_tag="Rv0215c"
                     /pseudogene="unknown"
                     /db_xref="GeneID:886730"
     gene            258913..259926
                     /locus_tag="Rv0216"
                     /db_xref="GeneID:886729"
     CDS             258913..259926
                     /locus_tag="Rv0216"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Double hotdog R-specific hydratase of unknown
                     function"
                     /codon_start=1
                     /transl_table=11
                     /product="hydratase"
                     /protein_id="NP_214730.1"
                     /db_xref="GeneID:886729"
                     /translation="MASGYGGIRVGGPYFDDLSKGQVFDWAPGVTLSLGLAAAHQSIV
                     GNRLRLALDSDLCAAVTGMPGPLAHPGLVCDVAIGQSTLATQRVKANLFYRGLRFHRF
                     PAVGDTLYTRTEVVGLRANSPKPGRAPTGLAGLRMTTIDRTDRLVLDFYRCAMLPASP
                     DWKPGAVPGDDLSRIGADAPAPAADPTAHWDGAVFRKRVPGPHFDAGIAGAVLHSTAD
                     LVSGAPELARLTLNIAATHHDWRVSGRRLVYGGHTIGLALAQATRLLPNLATVLDWES
                     CDHTAPVHEGDTLYSELHIESAQAHADGGVLGLRSLVYAVSDSASEPDRQVLDWRFSA
                     LQF"
     misc_feature    258946..259392
                     /locus_tag="Rv0216"
                     /note="FkbR2 is a Streptomyces hygroscopicus protein with
                     a hot dog fold that belongs to a conserved family of
                     proteins found in prokaryotes and archaea but not in
                     eukaryotes. FkbR2 has sequence similarity to (R)-specific
                     enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2;
                     cd03451"
                     /db_xref="CDD:239535"
     misc_feature    order(259033..259035,259048..259050,259054..259056,
                     259063..259065,259111..259113,259120..259125)
                     /locus_tag="Rv0216"
                     /note="putative active site [active]"
                     /db_xref="CDD:239535"
     misc_feature    order(259048..259050,259054..259056,259063..259065,
                     259120..259122)
                     /locus_tag="Rv0216"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:239535"
     misc_feature    259486..259917
                     /locus_tag="Rv0216"
                     /note="The hotdog fold was initially identified in the E.
                     coli FabA (beta-hydroxydecanoyl-acyl carrier protein
                     (ACP)-dehydratase) structure and subsequently in 4HBT
                     (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A
                     number of other seemingly unrelated...; Region: hot_dog;
                     cl00509"
                     /db_xref="CDD:321012"
     misc_feature    order(259657..259662,259747..259758)
                     /locus_tag="Rv0216"
                     /note="active site 2 [active]"
                     /db_xref="CDD:239524"
     misc_feature    order(259675..259677,259684..259689,259696..259698,
                     259723..259731)
                     /locus_tag="Rv0216"
                     /note="active site 1 [active]"
                     /db_xref="CDD:239524"
     gene            complement(259923..260831)
                     /gene="lipW"
                     /locus_tag="Rv0217c"
                     /db_xref="GeneID:886726"
     CDS             complement(259923..260831)
                     /gene="lipW"
                     /locus_tag="Rv0217c"
                     /codon_start=1
                     /transl_table=11
                     /product="esterase LipW"
                     /protein_id="NP_214731.1"
                     /db_xref="GeneID:886726"
                     /translation="MSGNEVHPDLRRIAVVTPRQLVGPRTLPVMRALIVVAGLRMSRT
                     PPDIEVLTLESGVGVRLYRPAGSNEPAPALLWIHAGGYVMGTAQQDDRLCLRFSSRLG
                     ITVASVDYRLAPENPYPAALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALAL
                     LARDRGGITPAFQLLVYPMLDDRPSIAPANPHYRLWNGRANRFGWRAYLGDADARVAV
                     PGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVEGAFHGFDRVAP
                     NVGVSQRFFTSQCNSLRAALALSNRT"
     misc_feature    complement(260019..260612)
                     /gene="lipW"
                     /locus_tag="Rv0217c"
                     /note="alpha/beta hydrolase fold; Region: Abhydrolase_3;
                     pfam07859"
                     /db_xref="CDD:311692"
     gene            260924..262252
                     /locus_tag="Rv0218"
                     /db_xref="GeneID:886727"
     CDS             260924..262252
                     /locus_tag="Rv0218"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214732.1"
                     /db_xref="GeneID:886727"
                     /translation="MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRG
                     PWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRPSWL
                     YRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQ
                     IVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLG
                     TNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKA
                     ALLLPRGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQ
                     RTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAARSARVTSLQRGGAFGEAKLAAN
                     QIADPDALLALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR"
     misc_feature    261056..262096
                     /locus_tag="Rv0218"
                     /note="Periplasmic DMSO/TMAO reductase YedYZ,
                     molybdopterin-dependent catalytic subunit [Energy
                     production and conversion]; Region: YedY; cl25394"
                     /db_xref="CDD:330215"
     misc_feature    261851..262249
                     /locus_tag="Rv0218"
                     /note="Sulfite oxidase (SO) family, molybdopterin binding
                     domain. This molybdopterin cofactor (Moco) binding domain
                     is found in a variety of oxidoreductases, main members of
                     this family are nitrate reductase (NR) and sulfite oxidase
                     (SO). SO catalyzes the...; Region: SO_family_Moco;
                     cd00321"
                     /db_xref="CDD:238198"
     misc_feature    261950..261952
                     /locus_tag="Rv0218"
                     /note="metal coordination site [ion binding]; other site"
                     /db_xref="CDD:238198"
     gene            262254..262802
                     /locus_tag="Rv0219"
                     /db_xref="GeneID:886725"
     CDS             262254..262802
                     /locus_tag="Rv0219"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214733.1"
                     /db_xref="GeneID:886725"
                     /translation="MFDIATRFKNSYGSGPLHLLAMVSGFALLGYIVATARPSALWNQ
                     ATWWQSIAVWFVAAVVAHDLLLYPLYALADRILARLVGRRDVSAPRRRPELPVRNYIR
                     IPALAAGLTLLVFLPGIIRQGAPTYLDATGQTQEPFLGRWLLLTAVAFGISAAAYAIR
                     LVVAHVRRRRAGCSRVDAIDEE"
     gene            262812..264023
                     /gene="lipC"
                     /locus_tag="Rv0220"
                     /db_xref="GeneID:886722"
     CDS             262812..264023
                     /gene="lipC"
                     /locus_tag="Rv0220"
                     /inference="protein motif:PROSITE:PS00122"
                     /codon_start=1
                     /transl_table=11
                     /product="esterase LipC"
                     /protein_id="NP_214734.1"
                     /db_xref="GeneID:886722"
                     /translation="MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHL
                     KPLGGVTAIGVWGARHASDFLSATAKDLLTPGINEVRRRDRASTQEVSVAALRGIVSP
                     DDLAVEWPAPERTPPVCGALRHRRYVHRRRVLYGDDPAQLLDVWRRKDMPTKPAPVLI
                     FVPGGAWVHGSRAIQGYAVLSRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWAR
                     ANVDKFGGDRNFIAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGR
                     YDWEDRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPFLVIHGSRD
                     CVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTGPTAHAIALFLNQVH
                     RSRAQFAKEVI"
     misc_feature    263052..263978
                     /gene="lipC"
                     /locus_tag="Rv0220"
                     /note="Acetyl esterase/lipase [Lipid transport and
                     metabolism]; Region: Aes; COG0657"
                     /db_xref="CDD:223730"
     gene            264067..265476
                     /locus_tag="Rv0221"
                     /db_xref="GeneID:886719"
     CDS             264067..265476
                     /locus_tag="Rv0221"
                     /experiment="DESCRIPTION:Gene expression[PMID:15262939]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="triacylglycerol synthase"
                     /codon_start=1
                     /transl_table=11
                     /product="diacyglycerol O-acyltransferase"
                     /protein_id="NP_214735.1"
                     /db_xref="GeneID:886719"
                     /translation="MKRLSGWDAVLLYSETPNVHMHTLKVAVIELDSDRQEFGVDAFR
                     EVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRPWRLRAPGGRRELDEA
                     VGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIHHALADGVASANMMARGMDLLPG
                     PEVGRYVPDPAPTKRQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLSPALT
                     MPFTPPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALRTLLL
                     RYDGKAEPLLASVPVSYDFSPERISGNRFTGMLVALPADSDDPLQRVRVCHENAVSAK
                     ESHQLLGPELISRWAAYWPPAGAEALFRWLSERDGQNKVLNLNISNVPGPRERGRVGA
                     ALVTEIYSVGPLTAGSGLNITVWSYVDQLNISVLTDGSTVQDPHEVTAGMIADFIEIR
                     RAAGLSVELTVVESAMAQA"
     misc_feature    264076..265425
                     /locus_tag="Rv0221"
                     /note="acyltransferase, WS/DGAT/MGAT; Region:
                     acyl_WS_DGAT; TIGR02946"
                     /db_xref="CDD:274360"
     gene            265507..266295
                     /gene="echA1"
                     /locus_tag="Rv0222"
                     /db_xref="GeneID:886723"
     CDS             265507..266295
                     /gene="echA1"
                     /locus_tag="Rv0222"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase EchA1"
                     /protein_id="NP_214736.1"
                     /db_xref="GeneID:886723"
                     /translation="MSSESDAANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGL
                     ADAMDQLDGDAGLSVAILTGGGGSFCAGMDLKAFARGENVVVEGRGLGFTERPPTKPL
                     IAAVEGYALAGGTELALAADLIVAARDSAFGIPEVKRGLVAGGGGLLRLPERIPYAIA
                     MELALTGDNLPAERAHELGLVNVLAEPGTALDAAIALAEKITANGPLAVVATKRIITE
                     SRGWSPDTMFAEQMKILVPVFTSNDAKEGAIAFAERRRPRWTGT"
     misc_feature    265534..266292
                     /gene="echA1"
                     /locus_tag="Rv0222"
                     /note="enoyl-CoA hydratase; Provisional; Region: PRK08252"
                     /db_xref="CDD:181325"
     misc_feature    order(265603..265605,265609..265611,265705..265707,
                     265717..265731,265831..265833,265837..265845,
                     265909..265914,265921..265923)
                     /gene="echA1"
                     /locus_tag="Rv0222"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:119339"
     misc_feature    order(265723..265725,265843..265845)
                     /gene="echA1"
                     /locus_tag="Rv0222"
                     /note="oxyanion hole (OAH) forming residues; other site"
                     /db_xref="CDD:119339"
     misc_feature    order(265807..265809,265870..265881,265915..265926,
                     265942..265944,265948..265956,265960..265965,
                     265978..265983,265987..265992,265996..266001,
                     266008..266010,266041..266043,266050..266052,
                     266095..266097,266104..266109)
                     /gene="echA1"
                     /locus_tag="Rv0222"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:119339"
     gene            complement(266301..267764)
                     /locus_tag="Rv0223c"
                     /db_xref="GeneID:886718"
     CDS             complement(266301..267764)
                     /locus_tag="Rv0223c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00070"
                     /inference="protein motif:PROSITE:PS00687"
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase"
                     /protein_id="NP_214737.1"
                     /db_xref="GeneID:886718"
                     /translation="MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAA
                     AADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPP
                     TIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYGQSIVSREPVGVVGAIVAWNVPL
                     FLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQA
                     LTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMM
                     VFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEK
                     QRTRVEGYIAKGIEEGARLVCGGGRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPV
                     LAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYGINWYAFDPGS
                     PFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA"
     misc_feature    complement(266325..267734)
                     /locus_tag="Rv0223c"
                     /note="Mycobacterium tuberculosis aldehyde dehydrogenase
                     AldA-like; Region: ALDH_AldA-Rv0768; cd07139"
                     /db_xref="CDD:143457"
     misc_feature    complement(order(266409..266411,266598..266600,
                     266604..266606,266901..266903,266997..267005,
                     267048..267050,267057..267059,267066..267077,
                     267117..267119,267225..267227,267294..267308))
                     /locus_tag="Rv0223c"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:143457"
     misc_feature    complement(order(266901..266903,266910..266912,
                     267003..267005,267294..267296))
                     /locus_tag="Rv0223c"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143457"
     gene            complement(267863..268627)
                     /locus_tag="Rv0224c"
                     /db_xref="GeneID:886715"
     CDS             complement(267863..268627)
                     /locus_tag="Rv0224c"
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase"
                     /protein_id="NP_214738.1"
                     /db_xref="GeneID:886715"
                     /translation="MAVTDVFARRATLRRSLRLLADFRYEQRDPARFYRTLAADTAAM
                     IGDLWLATHSEPPVGRTLLDVGGGPGYFATAFSDAGVGYIGVEPDPDEMHAAGPAFTG
                     RPGMFVRASGMALPFADDSVDICLSSNVAEHVPRPWQLGTEMLRVTKPGGLVVLSYTV
                     WLGPFGGHEMGLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGA
                     ALAVFPRYHPRWAWWLTSVPVLREFLVSNLVLVLTP"
     misc_feature    complement(267893..268576)
                     /locus_tag="Rv0224c"
                     /note="SAM-dependent methyltransferase [Secondary
                     metabolites biosynthesis, transport and catabolism,
                     General function prediction only]; Region: SmtA; COG0500"
                     /db_xref="CDD:223574"
     misc_feature    complement(268160..268441)
                     /locus_tag="Rv0224c"
                     /note="Methyltransferase domain; Region: Methyltransf_11;
                     pfam08241"
                     /db_xref="CDD:311935"
     misc_feature    complement(order(268244..268246,268292..268300,
                     268364..268369,268415..268435))
                     /locus_tag="Rv0224c"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:100107"
     gene            268663..269817
                     /locus_tag="Rv0225"
                     /db_xref="GeneID:886713"
     CDS             268663..269817
                     /locus_tag="Rv0225"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214739.1"
                     /db_xref="GeneID:886713"
                     /translation="MSALRSVLLLCWRDIGHPQGGGSEAYLQRIGAQLAASGIAVTLR
                     TARYPGAPRHELVDGVRISRAGGRYSVYLWALLAMAAARCGLGPLRRVRPDVVVDTQN
                     GWPFVARLLYGRRSLVLVHHCHREQWPVAGRMMGRLGWYVESMLSPRLHRRNQYVTVS
                     LPSARDLIALGVDSERIAVVRNGLDEAPSPTLSGPRAPTPRVVVLSRLVPHKQIEDAL
                     AAVAELQPRIPGLHLDIVGGGWWRQRLVDHVHRLDIADAVTFHGHVDDVTKHHVLQSS
                     WVHLLPSRKEGWGLAVIEAAQHGVPTIGYRSSGGLADSIVDGVTGILVDDRAELVAWL
                     EQLLSDSVLRDQLGAKAQARSGEFSWRQSAEALRSVLEAVQASRFVSGVV"
     misc_feature    268681..269778
                     /locus_tag="Rv0225"
                     /note="This family is most closely related to the GT1
                     family of glycosyltransferases and named after YqgM in
                     Bacillus licheniformis about which little is known.
                     Glycosyltransferases catalyze the transfer of sugar
                     moieties from activated donor molecules to...; Region:
                     GT1_YqgM_like; cd03801"
                     /db_xref="CDD:99974"
     gene            complement(269834..271564)
                     /locus_tag="Rv0226c"
                     /db_xref="GeneID:886711"
     CDS             complement(269834..271564)
                     /locus_tag="Rv0226c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214740.1"
                     /db_xref="GeneID:886711"
                     /translation="MRWFRPGYALVLVLLLAAPLLRPGYLLLRDAVSTPRSYVSANAL
                     GLTSAPRATPQDFAVALASHLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAG
                     QFVAITLAIWNPYVAERLLQGHWSLLVGYGCLPWVATAMLTMRTTVGAGWFGLFGLAF
                     WVALAGLTPSGLLLAATVAVVCVAMPGAGRPRWQCGVAALGSALVGALPWLTASALGS
                     SLTSHTAANQLGVTAFAPRAEPGLGTLGSLASLGGIWNGEAVPSSRTTLFAVASAVVL
                     LAMVAIGLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVLRD
                     GQKWVALAVPGYTLSGAGTVLTLRRWLRPATAAVVCCLALVLTLPDLAWGVWGKVAPV
                     HYPSGWAAVAAAINADPRTVAVLPAGTMRRFSWSGSAPVLDPLPRWVRADVLTTGDLV
                     ISGVTVPGEDAHARAVQELLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRLA
                     AAHRDDELALYRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLHHC
                     EDTPASRAQD"
     gene            complement(271574..272839)
                     /locus_tag="Rv0227c"
                     /db_xref="GeneID:886710"
     CDS             complement(271574..272839)
                     /locus_tag="Rv0227c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214741.1"
                     /db_xref="GeneID:886710"
                     /translation="MLRFAACGAIGLGAALLIAALLLSTYTTSRIAEIPLDIDATLIS
                     DGTGTALDSASLATEHIVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKD
                     SGLLLAIVDTVTLNRKTAMAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFP
                     FHTEKKTYPYFDPIAQKAFDANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSL
                     YAGDEDGKVTTSAAMWGLPGDPNEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYF
                     ARDPLKPEVTFADYQVTSTEETVESQVNAARDERDRLALWSRVLPITFTAAGLVALVG
                     GGLFASFSLRTEGALMAASGDRDDHDYRRGGFEEPVPGAEAETEKLPTQRPDFPREPS
                     GSDPPRLGSAQPPPPPDAGHPDPGPPERR"
     misc_feature    complement(271835..272767)
                     /locus_tag="Rv0227c"
                     /note="Protein of unknown function (DUF3068); Region:
                     DUF3068; pfam11271"
                     /db_xref="CDD:314255"
     repeat_region   complement(272855..272955)
                     /note="101 bp Mycobacterial Interspersed Repetitive
                     Unit,class III"
     gene            273055..274278
                     /locus_tag="Rv0228"
                     /db_xref="GeneID:886708"
     CDS             273055..274278
                     /locus_tag="Rv0228"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase"
                     /protein_id="NP_214742.1"
                     /db_xref="GeneID:886708"
                     /translation="MGPADESGAPIRPQTPHRHTVLVTNGQVVGGTRGFLPAVEGMRA
                     CAAVGVVVTHVAFQTGHSSGVGGRLFGRFDLAVAVFFAVSGFLLWRGHAAAARDLRSH
                     PRTGPYLRSRVARIMPAYVVAVVVILSLLPDADHASLTVWLANLTLTQIYVPLTLTGG
                     LTQMWSLSVEVAFYAALPVLALLGRRIPVGARVPAIAALAALSWAWGWLPLDAGSGIN
                     PLTWPPAFFSWFAAGMLLAEWAYSPVGLPHRWARRRVAMAVTALLGYLVAASPLAGPE
                     GLVPGTAAQFAVKTAMGSLVAFALVAPLVLDRPDTSHRLLGSPAMVTLGRWSYGLFIW
                     HLAALAMVFPVIGAFPFTGRMPTVLVLTLIFGFAIAAVSYALVESPCREALRRWERRN
                     EPISVGELQADAIAP"
     misc_feature    273133..274275
                     /locus_tag="Rv0228"
                     /note="Peptidoglycan/LPS O-acetylase OafA/YrhL, contains
                     acyltransferase and SGNH-hydrolase domains [Cell
                     wall/membrane/envelope biogenesis]; Region: OafA; COG1835"
                     /db_xref="CDD:224748"
     gene            complement(274306..274986)
                     /locus_tag="Rv0229c"
                     /db_xref="GeneID:886724"
     CDS             complement(274306..274719)
                     /locus_tag="Rv0229c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214743.2"
                     /db_xref="GeneID:886724"
                     /translation="MALKYLLDTSVIKRLSRPAVRRAVEPLAEAGAVARTQITDLEVG
                     YSARNETEWQRLMVALSAFDLIESTASHHRRALGIQRLLAARSQRGRKIPDLLIAAAG
                     EEHGLVVLHYDADFDLIAAVTGQPCQWIVPAGTID"
     misc_feature    complement(274333..274704)
                     /locus_tag="Rv0229c"
                     /note="PIN domain of the Rv0301 toxin of Mycobacterium
                     tuberculosis and other uncharacterized, annotated PilT
                     protein domain proteins; Region: PIN_MtRv0301; cd09882"
                     /db_xref="CDD:189052"
     misc_feature    complement(order(274381..274383,274435..274437,
                     274594..274596,274696..274698))
                     /locus_tag="Rv0229c"
                     /note="putative active site [active]"
                     /db_xref="CDD:189052"
     gene            complement(274983..275963)
                     /gene="php"
                     /locus_tag="Rv0230c"
                     /db_xref="GeneID:886705"
     CDS             complement(274983..275963)
                     /gene="php"
                     /locus_tag="Rv0230c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphotriesterase"
                     /protein_id="NP_214744.1"
                     /db_xref="GeneID:886705"
                     /translation="MPELNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDED
                     KRVAGAIARLGELKARGVDTIVDLTVIGLGRYIPRIARVAAATELNIVVATGLYTYND
                     VPFYFHYLGPGAQLDGPEIMTDMFVRDIEHGIADTGIKAGILKCATDEPGLTPGVERV
                     LRAVAQAHKRTGAPISTHTHAGLRRGLDQQRIFAEEGVDLSRVVIGHCGDSTDVGYLE
                     ELIAAGSYLGMDRFGVDVISPFQDRVNIVARMCERGHADKMVLSHDACCYFDALPEEL
                     VPVAMPNWHYLHIHNDVIPALKQHGVTDEQLHTMLVDNPRRIFERQGGYQ"
     misc_feature    complement(275004..275933)
                     /gene="php"
                     /locus_tag="Rv0230c"
                     /note="Phosphotriesterase family; Region: PTE; pfam02126"
                     /db_xref="CDD:280318"
     misc_feature    complement(order(275172..275174,275343..275345,
                     275430..275432,275529..275531,275892..275894,
                     275898..275900))
                     /gene="php"
                     /locus_tag="Rv0230c"
                     /note="active site"
                     /db_xref="CDD:238295"
     misc_feature    complement(order(275172..275174,275430..275432,
                     275670..275672,275892..275894))
                     /gene="php"
                     /locus_tag="Rv0230c"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:238295"
     misc_feature    complement(order(275559..275561,275580..275582,
                     275601..275603,275613..275615,275751..275753,
                     275877..275879))
                     /gene="php"
                     /locus_tag="Rv0230c"
                     /note="homodimer interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238295"
     gene            276058..277764
                     /gene="fadE4"
                     /locus_tag="Rv0231"
                     /db_xref="GeneID:886703"
     CDS             276058..277764
                     /gene="fadE4"
                     /locus_tag="Rv0231"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase FadE4"
                     /protein_id="NP_214745.1"
                     /db_xref="GeneID:886703"
                     /translation="MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHDDHERI
                     WYSDFLDFVGRERIFASLLTPASYGADDCRWDTYRISEFAEIMGFYGLSYWYPFQVTA
                     LGLGPIWMSANEDAKRKAAAGLEAGEVFAFGLSEQTHGADVYQTDMILTPSDGGWTAN
                     GEKYYIGNANVARMVSTFGKIAGTPESQEYVFFVADSQHERYDLIKNVVNSQNYVANY
                     ALRDYPVTEADILHRGAEAFHAALNTVNVCKYNLGWGAIGMCTHALYESVTHAANRHL
                     YGTVVTDFSHVRRLLTDAYVRLIAMKLVASRASDYMRSASAADRRYLLYSPLTKAKVT
                     SEGERVITALWDVIAAKGVEKDTFFETVAREIGLLPRLEGTVHINIGLLGKFMPNYLF
                     APDSTLPVIPRRDDAADDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQV
                     DVFAELLASATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFG
                     VLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVLALNGAYQM
                     AP"
     misc_feature    276109..277212
                     /gene="fadE4"
                     /locus_tag="Rv0231"
                     /note="Acyl-CoA dehydrogenase related to the alkylation
                     response protein AidB [Lipid transport and metabolism];
                     Region: CaiA; COG1960"
                     /db_xref="CDD:224871"
     gene            277899..278588
                     /locus_tag="Rv0232"
                     /db_xref="GeneID:886701"
     CDS             277899..278588
                     /locus_tag="Rv0232"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS01081"
                     /note="Belongs to the TetR/AcrR family of transcriptional
                     regulators."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214746.1"
                     /db_xref="GeneID:886701"
                     /translation="MPTVTWARVDPARRAAVVEAAEAEFGAHGFSRGSLNVIARRAGV
                     AKGSLFQYFADKRDLYAFIADIASQRVRSYMEDLIRELDPNRPFFEFLTDLLDGWVAY
                     FAEHPRERALHAAATLEVDTDARISVRSVLHRHYLDVLRPLVRDAHARGDLRADSDTG
                     ALMSLLLLIFPHLALAPYMRGLDPILGLDEPTPEQPALAVRRLVAVLAAAFDAQHPAT
                     NSAQTRSEEIT"
     misc_feature    277971..278450
                     /locus_tag="Rv0232"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            278585..279529
                     /gene="nrdB"
                     /locus_tag="Rv0233"
                     /gene_synonym="rnrS"
                     /db_xref="GeneID:886699"
     CDS             278585..279529
                     /gene="nrdB"
                     /locus_tag="Rv0233"
                     /gene_synonym="rnrS"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to the ribonucleoside diphosphate reductase
                     small chain family. Cofactor: iron, manganese"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonucleoside-diphosphate reductase subunit
                     beta NrdB"
                     /protein_id="NP_214747.1"
                     /db_xref="GeneID:886699"
                     /translation="MTRTRSGSLAAGGLNWASLPLKLFAGGNAKFWHPADIDFTRDRA
                     DWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSAMRAEGRLADEMYLTQFAFEEA
                     KHTQVFRMWLDAVGISEDLHRYLDDLPAYRQIFYAELPECLNALSADPSPAAQVRASV
                     TYNHIVEGMLALTGYYAWHKICVERAILPGMQELVRRIGDDERRHMAWGTFTCRRHVA
                     ADDANWTVFETRMNELIPLALRLIEEGFALYGDQPPFDLSKDDFLQYSTDKGMRRFGT
                     ISNARGRPVAEIDVDYSPAQLEDTFADEDRRTLAAASA"
     misc_feature    278585..279496
                     /gene="nrdB"
                     /locus_tag="Rv0233"
                     /gene_synonym="rnrS"
                     /note="ribonucleotide-diphosphate reductase subunit beta;
                     Validated; Region: PRK08326"
                     /db_xref="CDD:236242"
     misc_feature    order(278750..278752,278774..278776,278786..278788,
                     278795..278797,278873..278875,278885..278887,
                     278894..278896,278987..278989,279080..279085,
                     279095..279097,279104..279106,279113..279115,
                     279188..279190,279197..279199,279305..279307,
                     279320..279322,279368..279370)
                     /gene="nrdB"
                     /locus_tag="Rv0233"
                     /gene_synonym="rnrS"
                     /note="active site"
                     /db_xref="CDD:153120"
     misc_feature    order(278786..278788,278885..278887,278894..278896,
                     279083..279085,279107..279109,279188..279190,
                     279197..279199)
                     /gene="nrdB"
                     /locus_tag="Rv0233"
                     /gene_synonym="rnrS"
                     /note="diiron metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:153120"
     gene            complement(279605..281140)
                     /gene="gabD1"
                     /locus_tag="Rv0234c"
                     /gene_synonym="gabD2"
                     /db_xref="GeneID:886732"
     CDS             complement(279605..281140)
                     /gene="gabD1"
                     /locus_tag="Rv0234c"
                     /gene_synonym="gabD2"
                     /experiment="DESCRIPTION:Gene expression[PMID:16027371]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00070"
                     /note="[NADP+] dependent"
                     /codon_start=1
                     /transl_table=11
                     /product="succinate-semialdehyde dehydrogenase"
                     /protein_id="NP_216247.2"
                     /db_xref="GeneID:886732"
                     /translation="MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRF
                     VQTHPAKDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRA
                     RWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEP
                     ADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQ
                     CALYLADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAG
                     NEIKPTVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDD
                     FVDKFVARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLD
                     RPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGSNAWT
                     RDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSAHGIREFCNIKTV
                     WIA"
     misc_feature    complement(279608..280978)
                     /gene="gabD1"
                     /locus_tag="Rv0234c"
                     /gene_synonym="gabD2"
                     /note="succinic semialdehyde dehydrogenase; Reviewed;
                     Region: gabD1; PRK09406"
                     /db_xref="CDD:181826"
     misc_feature    complement(order(279695..279697,279809..279811,
                     279887..279889,279893..279895,280184..280186,
                     280280..280288,280328..280333,280340..280342,
                     280349..280360,280499..280504,280508..280510,
                     280553..280555,280577..280591))
                     /gene="gabD1"
                     /locus_tag="Rv0234c"
                     /gene_synonym="gabD2"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:143418"
     misc_feature    complement(order(280184..280186,280193..280195,
                     280286..280288,280577..280579))
                     /gene="gabD1"
                     /locus_tag="Rv0234c"
                     /gene_synonym="gabD2"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143418"
     gene            complement(281166..282614)
                     /locus_tag="Rv0235c"
                     /db_xref="GeneID:886695"
     CDS             complement(281166..282614)
                     /locus_tag="Rv0235c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214749.1"
                     /db_xref="GeneID:886695"
                     /translation="MGWFSAPEYWLGRLALERGTAIIYLIAFVAAAQQFRPLIGEHGM
                     LPVPRYLAGQSFWRTPSIFHFRYSDRVFAGVCWLGAVLSAAVVAGAASFVPLWATMLI
                     WLTLWVLYLSIVNVGQAWYSFGWESLLLETGFLMIFLGNERTAPPILTLLLARWLLFR
                     VEFGAGLIKMRGDSCWRSLTCLYYHHETQPMPGPLSWFFHHLPKPLHRIEVAGNHFAQ
                     LVVPFGLFTPQPAASIAAAIIVVTQLWLVASGNFSWLNWLTILLACSAIDTSSAAALL
                     PMPAQPALSAPPQWFAGLVVVFTAAVLLLSYWPARNLLSSHQRMNMSFNPFHLVNTYG
                     AFGSICRTRREVVIEGTDESPITEQTVWKAYEFKGKPGDPRRLPRQWAPYHLRLDWLM
                     WFAAISPGYALPWMTPFLNRLLRNDPATLKLLRHNPFPQSPPRYVRAQLYQYRFTTVA
                     ELRRDRAWWHRTLIGRYVPPMSLRKVASPPAD"
     misc_feature    complement(281202..282239)
                     /locus_tag="Rv0235c"
                     /note="Lipase maturation factor; Region: LMF1; pfam06762"
                     /db_xref="CDD:310995"
     gene            complement(282649..286851)
                     /gene="aftD"
                     /locus_tag="Rv0236c"
                     /db_xref="GeneID:886707"
     CDS             complement(282649..286851)
                     /gene="aftD"
                     /locus_tag="Rv0236c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="arabinofuranosyltransferase AftD. A core
                     mycobacterial gene; conserved in mycobacterial strains
                     (See Marmiesse et al., 2004 PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-(1->3)-arabinofuranosyltransferase"
                     /protein_id="NP_214750.1"
                     /db_xref="GeneID:886707"
                     /translation="MAPLSRKWLPVVGAVALALTFAQSPGQVSPDTKLDLTANPLRFL
                     ARATNLWNSDLPFGQAQNQAYGYLFPHGTFFVIGHLLGVPGWVTQRLWWAVLLTVGFW
                     GLLRVAEALGVGGPSSRVVGAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILAL
                     RGTSGRSVRALAAQAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRLWWRYTAWWL
                     LAMALATLWWVMALTQLHGVSPPFLDFIESSGVTTQWSSLVEVLRGTDSWTPFVAPNA
                     TAGAPLVTGSAAILGTCLVAAAGLAGLTSPAMPARGRLVTMLLVGVVLLAVGHRGGLA
                     SPVAHPVQAFLDAAGTPLRNVHKVGPVIRLPLVLGLAQLLSRVPLPGSAPRPAWLRAF
                     AHPERDKRVAVAVVALTALMVSTSLAWTGRVAPPGTFGALPQYWQEAADWLRTHHAAT
                     PTPGRVLVVPGAPFATQVWGTSHDEPLQVLGDGPWGVRDSIPLTPPQTIRALDSVQRL
                     FAAGRPSAGLADTLARQGISYVLVRNDLDPETSRSARPILLHRSIAGSPGLAKLAEFG
                     APVGPDPLAGFVNDSGLRPRYPAIEIYRVSAPANPGAPYFAATDQLARVDGGPEVLLR
                     LDERRRLQGQPPLGPVLMTADARAAGLPVPQVAVTDTPVARETDYGRVDHHSSAIRAP
                     GDARHTYNRVPDYPVPGAEPVVGGWTGGRITVSSSSADATAMPDVAPASAPAAAVDGD
                     PATAWVSNALQAAVGQWLQVDFDRPVTNAVVTLTPSATAVGAQVRRILIETVNGSTTL
                     RFDEAGKPLTAALPYGETPWVRFTAAATDDGSAGVQFGITDLAITQYDASGFAHPVQL
                     RHTVLVPGPPPGSAIAGWDLGSELLGRPGCAPGPDGVRCAASMALAPEEPANLSRTLT
                     VPRPVSVTPMVWVRPRQGPKLADLIAAPSTTRASGDSDLVDILGSAYAAADGDPATAW
                     TAPQRVVQHKTPPTLTLTLPRPTVVTGLRLAASRSMLPAHPTVVAINLGDGPQVRQLQ
                     VGELTTLWLHPRVTDTVSVSLLDWDDVIDRNALGFDQLKPPGLAEVVVLSAGGAPIAP
                     ADAARNRARALTVDCDHGPVVAVAGRFVHTSIRTTVGALLDGEPVAALPCEREPIALP
                     AGQQELLISPGAAFVVDGAQLSTPGAGLSSATVTSAETGAWGPTHREVRVPESATSRV
                     LVVPESINSGWVARTSTGARLTPIAVNGWQQAWVVPAGNPGTITLTFAPNSLYRASLA
                     IGLALLPLLALLAFWRTGRRQLADRPTPPWRPGAWAAAGVLAAGAVIASIAGVMVMGT
                     ALGVRYALRRRERLRDRVTVGLAAGGLILAGAALSRHPWRSVDGYAGNWASVQLLALI
                     SVSVVAASVVATSESRGQDRMQ"
     misc_feature    complement(284830..286806)
                     /gene="aftD"
                     /locus_tag="Rv0236c"
                     /note="Domain of unknown function (DUF3367); Region:
                     DUF3367; pfam11847"
                     /db_xref="CDD:314677"
     gene            complement(286898..287071)
                     /locus_tag="Rv0236A"
                     /db_xref="GeneID:3205106"
     CDS             complement(286898..287071)
                     /locus_tag="Rv0236A"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_177619.1"
                     /db_xref="GeneID:3205106"
                     /translation="MNRIVAPAAASVVVGLLLGAAAIFGVTLMVQQDKKPPLPGGDPS
                     SSVLNRVEYGNRS"
     misc_feature    complement(286904..287035)
                     /locus_tag="Rv0236A"
                     /note="Protein of unknown function (DUF2613); Region:
                     DUF2613; pfam11021"
                     /db_xref="CDD:314063"
     gene            287186..288352
                     /gene="lpqI"
                     /locus_tag="Rv0237"
                     /db_xref="GeneID:886693"
     CDS             287186..288352
                     /gene="lpqI"
                     /locus_tag="Rv0237"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00013"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein LpqI"
                     /protein_id="YP_177702.1"
                     /db_xref="GeneID:886693"
                     /translation="MAFPRTLAILAAAAALVVACSHGGTPTGSSTTSGASPATPVAVP
                     VPRSCAEPAGIPALLSPRDKLAQLLVVGVRDAADAQAVVTNYHVGGILIGSDTDLTIF
                     DGALAEIVAGGGPLPLAVSVDEEGGRVSRLRSLIGGTGPSARELAQTRTVQQVRDLAR
                     DRGRQMRKLGITIDFAPVVDVTDAPDDTVIGDRSFGSDPATVTAYAGAYAQGLRDAGV
                     LPVLKHFPGHGRGSGDSHNGGVTTPPLDDLVGDDLVPYRTLVTQAPVGVMVGHLQVPG
                     LTGSEPASLSKAAVNLLRTGTGYGAPPFDGPVFSDDLSGMAAISDRFGVSEAVLRTLQ
                     AGADIALWVTTKEVPAVLDRLEQALRAGELPMSAVDRSVVRVATMKGPNPGCGR"
     misc_feature    287369..288322
                     /gene="lpqI"
                     /locus_tag="Rv0237"
                     /note="Glycosyl hydrolase family 3 N terminal domain;
                     Region: Glyco_hydro_3; cl27622"
                     /db_xref="CDD:332443"
     gene            288428..289042
                     /locus_tag="Rv0238"
                     /db_xref="GeneID:886691"
     CDS             288428..289042
                     /locus_tag="Rv0238"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214752.1"
                     /db_xref="GeneID:886691"
                     /translation="MAGGTKRLPRAVREQQMLDAAVQMFSVNGYHETSMDAIAAEAQI
                     SKPMLYLYYGSKEDLFGACLNREMSRFIDALRSSINFDQSPKDLLRNTIVSFLRYIDA
                     NRASWIVMYTQATSSQAFAHTVREGREQIVQLVAELVRAGTRGPLTDAEIEMMAVALV
                     GAGEAVATRLGIGDTDVDEAAEMMINLFWLGLKGAPVDRLETGH"
     misc_feature    288428..289012
                     /locus_tag="Rv0238"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            289104..289337
                     /gene="vapB24"
                     /locus_tag="Rv0239"
                     /db_xref="GeneID:886689"
     CDS             289104..289337
                     /gene="vapB24"
                     /locus_tag="Rv0239"
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin VapB24"
                     /protein_id="NP_214753.1"
                     /db_xref="GeneID:886689"
                     /translation="MIRTQVQLPDELYRDAKRVAHEHEMTLAEVVRRGLEHMVRIYPR
                     RDAASDTWQPPTPRRLGPFRASEETWRELANEA"
     gene            289345..289782
                     /gene="vapC24"
                     /locus_tag="Rv0240"
                     /db_xref="GeneID:886688"
     CDS             289345..289782
                     /gene="vapC24"
                     /locus_tag="Rv0240"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="toxin, Contains PIN domain"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease VapC24"
                     /protein_id="NP_214754.1"
                     /db_xref="GeneID:886688"
                     /translation="MLSIDTNILLYAQNRDCPEHDAAAAFLVECAGRADVAVCELVLM
                     ELYQLLRNPTVVTRPLEGPEAAEVCQTFRRNRRWALLENAPVMNEVWVLAATPRIARR
                     RLFDARLALTLRHHGVDEFATRNINGFTDFGFSRVWDPITSDG"
     misc_feature    289345..289773
                     /gene="vapC24"
                     /locus_tag="Rv0240"
                     /note="toxin-antitoxin system PIN domain toxin; Region:
                     Mtu_PIN_fam; TIGR00028"
                     /db_xref="CDD:272863"
     gene            complement(289812..290654)
                     /gene="htdX"
                     /locus_tag="Rv0241c"
                     /db_xref="GeneID:886686"
     CDS             complement(289812..290654)
                     /gene="htdX"
                     /locus_tag="Rv0241c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-thioester dehydratase HtdX"
                     /protein_id="NP_214755.1"
                     /db_xref="GeneID:886686"
                     /translation="MTQPSGLKNLLRAAAGALPVVPRTDQLPNRTVTVEELPIDPANV
                     AAYAAVTGLRYGNQVPLTYPFALTFPSVMSLVTGFDFPFAAMGAIHTENHITQYRPIA
                     VTDAVGVRVRAENLREHRRGLLVDLVTNVSVGNDVAWHQVTTFLHQQRTSLSGEPKPP
                     PQKKPKLPPPAAVLRITPAKIRRYAAVGGDHNPIHTNPIAAKLFGFPTVIAHGMFTAA
                     AVLANIEARFPDAVRYSVRFAKPVLLPATAGLYVAEGDGGWDLTLRNMAKGYPHLTAT
                     VRGL"
     misc_feature    complement(289941..>290462)
                     /gene="htdX"
                     /locus_tag="Rv0241c"
                     /note="enoyl-CoA hydratase; Region: PLN02864"
                     /db_xref="CDD:178455"
     misc_feature    complement(289827..290129)
                     /gene="htdX"
                     /locus_tag="Rv0241c"
                     /note="MaoC like domain; Region: MaoC_dehydratas;
                     pfam01575"
                     /db_xref="CDD:307626"
     misc_feature    complement(order(289932..289943,290016..290021))
                     /gene="htdX"
                     /locus_tag="Rv0241c"
                     /note="active site 2 [active]"
                     /db_xref="CDD:239524"
     gene            complement(290665..292029)
                     /gene="fabG4"
                     /locus_tag="Rv0242c"
                     /db_xref="GeneID:886697"
     CDS             complement(290665..292029)
                     /gene="fabG4"
                     /locus_tag="Rv0242c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00061"
                     /note="Belongs to the short-chain
                     dehydrogenases/reductases (SDR) family."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="NP_214756.1"
                     /db_xref="GeneID:886697"
                     /translation="MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPL
                     TGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGL
                     HEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTAL
                     VYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIV
                     TGAARGIGATIAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDK
                     ISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNG
                     SIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGF
                     IETQMTAAIPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQA
                     MIGA"
     misc_feature    complement(290668..292011)
                     /gene="fabG4"
                     /locus_tag="Rv0242c"
                     /note="3-ketoacyl-(acyl-carrier-protein) reductase;
                     Provisional; Region: fabG; PRK08261"
                     /db_xref="CDD:236207"
     gene            292171..293493
                     /gene="fadA2"
                     /locus_tag="Rv0243"
                     /db_xref="GeneID:886682"
     CDS             292171..293493
                     /gene="fadA2"
                     /locus_tag="Rv0243"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00099"
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA acetyltransferase FadA"
                     /protein_id="NP_214757.1"
                     /db_xref="GeneID:886682"
                     /translation="MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAA
                     LSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTG
                     LQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLV
                     GTLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDR
                     GFFDDLVSPFLGLYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASV
                     ALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQD
                     FDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPF
                     AATGGRILAQTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA"
     misc_feature    292189..293490
                     /gene="fadA2"
                     /locus_tag="Rv0243"
                     /note="acetyl-CoA acetyltransferase; Provisional; Region:
                     PRK09268"
                     /db_xref="CDD:236440"
     gene            293604..293705
                     /gene="F6"
                     /locus_tag="RVnc0008"
                     /gene_synonym="mcr14; mpr13"
                     /db_xref="GeneID:14515886"
     ncRNA           293604..293705
                     /ncRNA_class="other"
                     /gene="F6"
                     /locus_tag="RVnc0008"
                     /gene_synonym="mcr14; mpr13"
                     /product="Putative small regulatory RNA"
                     /note="F6, putative small regulatory RNA (See Arnvig and
                     Young, 2009; DiChiara et al., 2010). Alternate 3'-ends at
                     positions 293641 and 293661."
                     /db_xref="GeneID:14515886"
     gene            complement(293798..295633)
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /db_xref="GeneID:886698"
     CDS             complement(293798..295633)
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase FadE5"
                     /protein_id="NP_214758.1"
                     /db_xref="GeneID:886698"
                     /translation="MSHYRSNVRDQVFNLFEVLGVDKALGHGEFSDVDVDTARDMLAE
                     VSRLAEGPVAESFVEGDRNPPVFDPKTHSVMLPESFKKSVNAMLEAGWDKVGIDEALG
                     GMPMPKAVVWALHEHILGANPAVWMYAGGAGFAQILYHLGTEEQKKWAVLAAERGWGS
                     TMVLTEPDAGSDVGAARTKAVQQADGSWHIDGVKRFITSGDSGDLFENIFHLVLARPE
                     GAGPGTKGLSLYFVPKFLFDVETGEPGERNGVFVTNVEHKMGLKVSATCELAFGQHGV
                     PAKGWLVGEVHNGIAQMFEVIEQARMMVGTKAIATLSTGYLNALQYAKSRVQGADLTQ
                     MTDKTAPRVTITHHPDVRRSLMTQKAYAEGLRALYLYTATFQDAAVAEVVHGVDAKLA
                     VKVNDLMLPVVKGVGSEQAYAKLTESLQTLGGSGFLQDYPIEQYIRDAKIDSLYEGTT
                     AIQAQDFFFRKIVRDKGVALAHVSGQIQEFVDSGAGNGRLKTERALLAKALTDVQGMA
                     AALTGYLMAAQQDVTSLYKVGLGSVRFLMSVGDLIIGWLLQRQAAVAVAALDAGATGD
                     ERSFYEGKVAVASFFAKNFLPLLTSTREVIETLDNDIMELDEAAF"
     misc_feature    complement(295532..295624)
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /note="Acyl-CoA dehydrogenase N terminal; Region:
                     AcylCoA_DH_N; pfam12418"
                     /db_xref="CDD:315151"
     misc_feature    complement(294245..295513)
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /note="Putative acyl-CoA dehydrogenases similar to fadE5;
                     Region: ACAD_fadE5; cd01153"
                     /db_xref="CDD:173842"
     misc_feature    complement(order(294281..294283,294287..294289,
                     294308..294310,295040..295042,295046..295048,
                     295121..295126,295139..295144,295148..295150))
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173842"
     misc_feature    complement(order(294290..294295,294959..294961,
                     295121..295123))
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173842"
     misc_feature    complement(294290..294295)
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:173842"
     misc_feature    complement(293816..294211)
                     /gene="fadE5"
                     /locus_tag="Rv0244c"
                     /note="Acetyl-CoA dehydrogenase C-terminal like; Region:
                     Acyl-CoA_dh_C; pfam12806"
                     /db_xref="CDD:315475"
     gene            296005..296493
                     /locus_tag="Rv0245"
                     /db_xref="GeneID:886680"
     CDS             296005..296493
                     /locus_tag="Rv0245"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214759.1"
                     /db_xref="GeneID:886680"
                     /translation="MNSTNNLTPSSLREAFGHFPTGVVAIAAEVDGVRQGLAASTFVP
                     VSLEPPLVSFCVQNTSTTWPKLTGVPMLGISVLGEAHDAAVRTLAAKTGDRFAGLETV
                     SNDAGAVFIKGTSVWLESAIEQLVPAGDHTIVVLRVNQVKVDPNVAPIVFHRSVLRRL
                     GV"
     misc_feature    296035..296490
                     /locus_tag="Rv0245"
                     /note="NADH-FMN oxidoreductase RutF, flavin reductase
                     (DIM6/NTAB) family [Energy production and conversion];
                     Region: RutF; COG1853"
                     /db_xref="CDD:224766"
     gene            296809..298119
                     /locus_tag="Rv0246"
                     /db_xref="GeneID:886678"
     CDS             296809..298119
                     /locus_tag="Rv0246"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane protein"
                     /protein_id="NP_214760.1"
                     /db_xref="GeneID:886678"
                     /translation="MAKTSHRVSSADGMSKRILRLIIAQSGFYSAALQLGNVSIVLPF
                     VVAELDAELWIAALIFPAFTAGGAIGNVVAPPAVAAVPRRHRLFIIVSCLAVLAGVNA
                     LCATIGKGSVAGILLVVNVTLIGVVSAISFVAFADLVAAMPSGTARARILLTEVGVGA
                     ALTAVVAATLSFVPDQHPLSRNIHLLWTAAVAMAISAAICRALPHRIVPRVHAAPGLH
                     KLVYVGWTAIRTNGWYRRYLLVQVLFGSVVLGSSFHSIRVAAVPGDQPDEVVAVVLFV
                     CVGLLGGIALWNRVRERFGLVGLFVGSALVSIAAAVLSIAFDLAGAWPNVVAIGLVIA
                     LVSIANQSVFTAGQLWIARDAEPGLRTSLISFGQLVINAGLVGMGLALGLIAQDHDAV
                     WPVMIVLLLNLTAAYSATRFAPAKSVDVRGLPQVSRTSRPKTGG"
     gene            complement(298116..298862)
                     /locus_tag="Rv0247c"
                     /db_xref="GeneID:886677"
     CDS             complement(298116..298862)
                     /locus_tag="Rv0247c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00197"
                     /note="Note that succinate dehydrogenase forms generally
                     part of an enzyme complex containing four subunits: a
                     flavoprotein (Rv0248c), an iron-sulfur (Rv0247c), and two
                     hydrophobic anchor proteins (Rv0249c)."
                     /codon_start=1
                     /transl_table=11
                     /product="succinate dehydrogenase iron-sulfur subunit"
                     /protein_id="NP_214761.1"
                     /db_xref="GeneID:886677"
                     /translation="MTYSASMRVWRGDESCGELREFTVEVNEGEVVLDVILRLQQTQT
                     PDLAVRWNCKAGKCGSCSAEINGKPRLMCMTRMSTFDEDEIVTVTPMRTFPVIRDLVT
                     DVSFNYQKAREIPSFAPPKELQPSEYRMAQVDVARSQEFRKCIECFLCQNVCHVVRDH
                     EENKDAFAGPRFLMRIAELEMHPLDTRDRRSQAQEEHGLGYCNITKCCTEVCPENIKI
                     TDNALIPMKERVADRKYDPVVWLGSKLFRR"
     misc_feature    complement(298119..298862)
                     /locus_tag="Rv0247c"
                     /note="fumarate reductase iron-sulfur subunit;
                     Provisional; Region: PRK12386"
                     /db_xref="CDD:237086"
     gene            complement(298863..300803)
                     /locus_tag="Rv0248c"
                     /db_xref="GeneID:886675"
     CDS             complement(298863..300803)
                     /locus_tag="Rv0248c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00141"
                     /note="Note that succinate dehydrogenase forms generally
                     part of an enzyme complex containing four subunits: a
                     flavoprotein (Rv0248c), an iron-sulfur (Rv0247c), and two
                     hydrophobic anchor proteins (Rv0249c)."
                     /codon_start=1
                     /transl_table=11
                     /product="succinate dehydrogenase flavoprotein subunit"
                     /protein_id="NP_214762.1"
                     /db_xref="GeneID:886675"
                     /translation="MVEVERHSYDVVVIGAGGAGLRAVIEARERGLKVAVVCKSLFGK
                     AHTVMAEGGCAAAMGNANPKDNWKTHFGDTMRGGKFLNNWRMAELHAKEAPDRVWELE
                     TYGALFDRTDDGRISQRNFGGHTYPRLAHVGDRTGLELIRTLQQKVVSLQQEDHAELG
                     DYEARIKVFAECTITELLKDQGAIAGAFGYWRESGRFIVFEAPAVVLATGGIGKSFKV
                     TSNSWEYTGDGHALALRAGATLINMEFVQFHPTGMVWPPSVKGILVTEGVRGDGGVLK
                     NSENSRFMFDYIPPVFKGQYAETEEEADQWLKDNDSARRTPDLLPRDEVARAINSEVK
                     AGRGTPHGGVYLDIASRLTPAEIKRRLPSMYHQFKELAEVDITTQAMEVGPTCHYVMG
                     GVEVDADTGAATVPGLFAAGECAGGMHGSNRLGGNSLSDLLVFGRRAGLGAADYVRAL
                     SSRPAVSAEAIDAAAQQALSPFEGPKDGSAPENPYALHMDLQYVMNDLVGIIRNADEI
                     SRALTLLAELWSRYHNVLVEGHRQYNPGWNLSIDLRNMLLVSECVARAALQRTESRGG
                     HTRDDHPGMDPNWRRILLVCRATETMGTGGSGSGDSNCHINVTQQLQTPMRPDLLELF
                     EISELEKYYTDEELAEHPGRRG"
     misc_feature    complement(298884..300803)
                     /locus_tag="Rv0248c"
                     /note="succinate dehydrogenase flavoprotein subunit;
                     Reviewed; Region: sdhA; PRK07803"
                     /db_xref="CDD:236101"
     gene            complement(300834..301655)
                     /locus_tag="Rv0249c"
                     /db_xref="GeneID:886671"
     CDS             complement(300834..301655)
                     /locus_tag="Rv0249c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Note that succinate dehydrogenase forms generally
                     part of an enzyme complex containing four subunits: a
                     flavoprotein (Rv0248c), an iron-sulfur (Rv0247c), and two
                     hydrophobic anchor proteins (Rv0249c)."
                     /codon_start=1
                     /transl_table=11
                     /product="succinate dehydrogenase membrane anchor subunit"
                     /protein_id="NP_214763.1"
                     /db_xref="GeneID:886671"
                     /translation="MSAPTANRPAIGVFTPTRAQIPERTLRTDLWWLPPLLTNLGLLA
                     FICYATTRAFWGSQYWVEKYHYLTPFYSPCVSASCQPGASHLGVWFGHFPGWIPLGAM
                     VLPFLLGFRLTCYYYRKAYYRSVWQSPTSCAVPEPRAHYTGETRLPLIVQNTHRYFFY
                     IAVVVSLINTYDAIAAFHSPSGFGFGLGNVILTINVVLLWAYTISCHSCRHATGGRLK
                     HFSKHPVRYWIWTQVSKLNTRHMQFAWITLGTLALTDFYIMLVASGSITDLRFIG"
     gene            complement(301735..302028)
                     /locus_tag="Rv0250c"
                     /db_xref="GeneID:886669"
     CDS             complement(301735..302028)
                     /locus_tag="Rv0250c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214764.1"
                     /db_xref="GeneID:886669"
                     /translation="MSTTAELAELHDLVGGLRRCVTALKARFGDNPATRRIVIDADRI
                     LTDIELLDTDVSELDLERAAVPQPSEKIAIPDTEYDREFWRDVDDEGVGGHRY"
     gene            complement(302173..302652)
                     /gene="hsp"
                     /locus_tag="Rv0251c"
                     /gene_synonym="acr2; hrpA; hsp20"
                     /db_xref="GeneID:886667"
     CDS             complement(302173..302652)
                     /gene="hsp"
                     /locus_tag="Rv0251c"
                     /gene_synonym="acr2; hrpA; hsp20"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Hsp (alternate gene name: hsp20, hrpA, acr2),
                     heat-stress-induced ribosome-binding protein A. Belongs to
                     the small heat shock protein (HSP20) family."
                     /codon_start=1
                     /transl_table=11
                     /product="heat shock protein"
                     /protein_id="NP_214765.1"
                     /db_xref="GeneID:886667"
                     /translation="MNNLALWSRPVWDVEPWDRWLRDFFGPAATTDWYRPVAGDFTPA
                     AEIVKDGDDAVVRLELPGIDVDKDVNVELDPGQPVSRLVIRGEHRDEHTQDAGDKDGR
                     TLREIRYGSFRRSFRLPAHVTSEAIAASYDAGVLTVRVAGAYKAPAETQAQRIAITK"
     misc_feature    complement(302182..302601)
                     /gene="hsp"
                     /locus_tag="Rv0251c"
                     /gene_synonym="acr2; hrpA; hsp20"
                     /note="Molecular chaperone IbpA, HSP20 family
                     [Posttranslational modification, protein turnover,
                     chaperones]; Region: IbpA; COG0071"
                     /db_xref="CDD:223149"
     gene            302866..305427
                     /gene="nirB"
                     /locus_tag="Rv0252"
                     /gene_synonym="nasB"
                     /db_xref="GeneID:886665"
     CDS             302866..305427
                     /gene="nirB"
                     /locus_tag="Rv0252"
                     /gene_synonym="nasB"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00365"
                     /note="nirB (alternate gene name: nasB), nitrite reductase
                     [NAD(P)H] large subunit, flavoprotein containing siroheme
                     and a 2FE-2S iron-sulfur center. Cofactors: FAD; Iron;
                     Siroheme."
                     /codon_start=1
                     /transl_table=11
                     /product="nitrite reductase large subunit NirB"
                     /protein_id="NP_214766.1"
                     /db_xref="GeneID:886665"
                     /translation="MPTAGSSRAPAAAREIVVVGHGMVGHRLVEAVRARDADGSLRIT
                     VLAEEGDAAYDRVGLTSYTESWDRALLALPGNDYAGDQRVRLLLNTRVTQIDRATKSV
                     VTAAGQRHRYDTLVLATGSYAFVPPVPGHDLPACHVYRTFDDLDAIRAGAQRTLDGGH
                     TDGGVVIGGGLLGLEAANALRQFGLQTHVVEMMPRLMAQQIDEAGGALLARMIADLGI
                     AVHVGTGTESIESVKHSDGSVWARVRLSDGEVIDAGVVIFAAGIRPRDELARAAGLAI
                     GDRGGVLTDLSCRTSDPDIYAVGEVAAIDGRCYGLVGPGYTSAEVVADRLLDGSAEFP
                     EADLSTKLKLLGVDVASFGDAMGATENCLEVVINDAVKRTYAKLVLSDDATTLLGGVL
                     VGDASSYGVLRPMVGAELPGDPLALIAPAGSGAGAGALGVGALPDSAQICSCNNVTKG
                     ELKCAIADGCGDVPALKSCTAAGTSCGSCVPLLKQLLEAEGVEQSKALCEHFSQSRAE
                     LFEIITATEVRTFSGLLDRFGRGKGCDICKPVVASILASTGSDHILDGEQASLQDSND
                     HFLANIQKNGSYSVVPRVPGGDIKPEHLILIGQIAQDFGLYTKITGGQRIDLFGARVD
                     QLPLIWQRLVDGGMESGHAYGKAVRTVKSCVGSDWCRYGQQDSVQLAIDLELRYRGLR
                     APHKIKLGVSGCARECAEARGKDVGVIATEKGWNLYVAGNGGMTPKHAQLLASDLDKE
                     TLIRYIDRFLIYYIRTADRLQRTAPWVESLGLDHVREVVCEDSLGLAEEFEAAMQRHV
                     ANYKCEWKGVLEDPDKLSRFVSFVNAPDAVDSTVTFTERAGRKVPVSIGIPRVRS"
     misc_feature    302911..305301
                     /gene="nirB"
                     /locus_tag="Rv0252"
                     /gene_synonym="nasB"
                     /note="NAD(P)H-nitrite reductase, large subunit [Energy
                     production and conversion]; Region: NirB; cl26176"
                     /db_xref="CDD:330997"
     gene            305453..305809
                     /gene="nirD"
                     /locus_tag="Rv0253"
                     /db_xref="GeneID:886664"
     CDS             305453..305809
                     /gene="nirD"
                     /locus_tag="Rv0253"
                     /note="nirD,nitrite reductase [NAD(P)H] small subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="nitrite reductase small subunit NirD"
                     /protein_id="NP_214767.1"
                     /db_xref="GeneID:886664"
                     /translation="MTLLNDIQVWTTACAYDHLIPGRGVGVLLDDGSQVALFRLDDGS
                     VHAVGNVDPFSGAAVMSRGIVGDRGGRAMVQSPILKQAFALDDGSCLDDPRVSVPVYP
                     ARVTPEGRIQVARVAV"
     misc_feature    305480..305794
                     /gene="nirD"
                     /locus_tag="Rv0253"
                     /note="Rieske-like [2Fe-2S] domain; Region: Rieske_2;
                     pfam13806"
                     /db_xref="CDD:316336"
     gene            complement(305825..306349)
                     /gene="cobU"
                     /locus_tag="Rv0254c"
                     /db_xref="GeneID:886661"
     CDS             complement(305825..306349)
                     /gene="cobU"
                     /locus_tag="Rv0254c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /note="cobU,cobalamin biosynthesis protein including a
                     cobinamide kinase and cobinamide phosphate
                     guanylyltransferase."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional cobinamide kinase/cobinamide
                     phosphate guanylyltransferase"
                     /protein_id="NP_214768.1"
                     /db_xref="GeneID:886661"
                     /translation="MRILVTGGVRSGKSTHAEALLGDAADVVYVAPGRPAAGSDPDWD
                     ARVALHRARRPPTWLTVETADVATALSEARSPVLVDCLGTWLTAIMDGEALWSAATAD
                     VYAVLEARLDGLCAALTGLPTAIVVTNEVGLGVVPSHSSGVLFRDLLGTINRRVAAVC
                     DEVHLVIAGRVLKL"
     misc_feature    complement(305828..306349)
                     /gene="cobU"
                     /locus_tag="Rv0254c"
                     /note="Adenosyl cobinamide kinase/adenosyl cobinamide
                     phosphate guanylyltransferase [Coenzyme transport and
                     metabolism]; Region: CobU; COG2087"
                     /db_xref="CDD:224998"
     gene            complement(306374..307858)
                     /gene="cobQ1"
                     /locus_tag="Rv0255c"
                     /gene_synonym="cobQ"
                     /db_xref="GeneID:886673"
     CDS             complement(306374..307858)
                     /gene="cobQ1"
                     /locus_tag="Rv0255c"
                     /gene_synonym="cobQ"
                     /note="Belongs to the COBB/COBQ family, COBQ subfamily."
                     /codon_start=1
                     /transl_table=11
                     /product="cobyric acid synthase"
                     /protein_id="YP_177703.1"
                     /db_xref="GeneID:886673"
                     /translation="MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNN
                     SMVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWGEV
                     ASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGDYVNMGLARHAG
                     LPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNKFRGDSDLLAPGLRDLERV
                     TGRRVYGTLPWHPDLWLDSEDALDLQGRRAAGTGARRVAVVRLPRISNFTDVDALGLE
                     PDLDVVFASDPRALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGIC
                     GGFQMLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGVPASG
                     YEIHHGRITRGDTAEEFLGGARDGPVFGTMWHGSLEGDALREAFLRETLGLAPSGSCF
                     LAARERRLDLLGDLVERHLDVDALLNLARHGCPPTLPFLAPGAP"
     misc_feature    complement(306425..307858)
                     /gene="cobQ1"
                     /locus_tag="Rv0255c"
                     /gene_synonym="cobQ"
                     /note="cobyric acid synthase; Provisional; Region:
                     PRK00784"
                     /db_xref="CDD:234838"
     gene            complement(307877..309547)
                     /gene="PPE2"
                     /locus_tag="Rv0256c"
                     /db_xref="GeneID:886684"
     CDS             complement(307877..309547)
                     /gene="PPE2"
                     /locus_tag="Rv0256c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE2"
                     /protein_id="YP_177704.1"
                     /db_xref="GeneID:886684"
                     /translation="MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIAYAET
                     ADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMATRQETAATAYGT
                     ALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNESDYARMWIQAATTMASYQAV
                     STAAVAAAPQTTPAPQIVKANAPTAASDEPNQVQEWLQWLQKIGYTDFYNNVIQPFIN
                     WLTNLPFLQAMFSGFDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFI
                     GADLAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPLLA
                     APLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIPTPTPTPAPAP
                     APTAVTAPTPPPGPPPPPVTAPPPVTGAGIQSFGYLVGDLNSAAQARKAVGTGVRKKT
                     PEPDSAEAPAAAAAPEEQVQPQRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQGAGT
                     LGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE"
     misc_feature    complement(309074..309526)
                     /gene="PPE2"
                     /locus_tag="Rv0256c"
                     /note="PPE family; Region: PPE; pfam00823"
                     /db_xref="CDD:307116"
     gene            309699..310073
                     /locus_tag="Rv0257"
                     /db_xref="GeneID:3205110"
     CDS             309699..310073
                     /locus_tag="Rv0257"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_177620.1"
                     /db_xref="GeneID:3205110"
                     /translation="MTRVSWLPDRCLPRLPACGRGLRGSLPGDSGGTAPDSHRLPASS
                     SPDGKNIGMQSVDLHVERHLPSRGRSHRTVATVTCVTALGDIRSAQLSATGAWPAVLF
                     PSWSWLCGIGGGVDLQKPSCRA"
     gene            complement(310294..310749)
                     /locus_tag="Rv0258c"
                     /db_xref="GeneID:886654"
     CDS             complement(310294..310749)
                     /locus_tag="Rv0258c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214772.1"
                     /db_xref="GeneID:886654"
                     /translation="MARSQEPSRGLLDPVAKMLRLPFGTPDFIEKIVTGSVNQVGRRT
                     LYVLITTWDAAGGGPFAASAIATTGLAKTAEIVQSMFIGPVFNPLLKMLGADKIAIRA
                     SLCAAQLVGLGIMRYGVRSEPLHSMSVEMLVDAIGPTMQRYLVGDIGRG"
     gene            complement(310774..311517)
                     /locus_tag="Rv0259c"
                     /db_xref="GeneID:886657"
     CDS             complement(310774..311517)
                     /locus_tag="Rv0259c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214773.1"
                     /db_xref="GeneID:886657"
                     /translation="MNLILTAHGTRRPSGVAMIADIAAQVSALVDRTVQVAFVDVLGP
                     SPSEVLSALSCRPAIVVPAFLSRGYHVRTDLPAHVAASAHPHVTVTPALGPCREIAQI
                     VTQQLVESGWRPGDSVILAAAGASDRRARADLHTTRTLVSELTGSWVDMGFAGTGGPD
                     VRTAVQRARDRAEANRGARRVAVASFLLAEGLFQERLRASGADVVTRPLGTHPGLAQL
                     VANRFRSAVARQQRLHRWHGTPTPVTLDL"
     misc_feature    complement(310822..311517)
                     /locus_tag="Rv0259c"
                     /note="Sirohydrochlorin ferrochelatase [Coenzyme transport
                     and metabolism]; Region: SirB; COG2138"
                     /db_xref="CDD:225049"
     misc_feature    complement(order(310942..310944,311149..311151))
                     /locus_tag="Rv0259c"
                     /note="putative active site [active]"
                     /db_xref="CDD:239507"
     gene            complement(311514..312659)
                     /locus_tag="Rv0260c"
                     /db_xref="GeneID:886651"
     CDS             complement(311514..312659)
                     /locus_tag="Rv0260c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214774.1"
                     /db_xref="GeneID:886651"
                     /translation="MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKM
                     IALPDDDELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARII
                     SRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFP
                     EFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLE
                     RSRELDIEDQLLAALRTDVHAMCVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEEL
                     PLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRV
                     LPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKRGYRLAVDSRHDDV"
     misc_feature    complement(311517..312659)
                     /locus_tag="Rv0260c"
                     /note="bifunctional uroporphyrinogen-III
                     synthetase/response regulator domain protein; Validated;
                     Region: PRK07239"
                     /db_xref="CDD:235981"
     gene            complement(312759..314168)
                     /gene="narK3"
                     /locus_tag="Rv0261c"
                     /db_xref="GeneID:886663"
     CDS             complement(312759..314168)
                     /gene="narK3"
                     /locus_tag="Rv0261c"
                     /note="Belongs to the nark/NASA family of transporters."
                     /codon_start=1
                     /transl_table=11
                     /product="nitrate/nitrite transporter"
                     /protein_id="NP_214775.1"
                     /db_xref="GeneID:886663"
                     /translation="MGRSHQISDWDPEDSVAWEAGNKFIARRNLIWSVAAEHVGFSVW
                     SLWSVMVLFMPTSVYGFSAGDKFLLGATATLVGACLRFPYTFATAKFGGRNWTIFSAL
                     VLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAASMTNINAFFPQRLKGAALA
                     LNAGGGNLGVPMVQLVGLLVIATAGDREPYWVCAIYLVLLAVAGLGAALYMDNLTEYR
                     IELNTMRAVVSEPHTWVISLLYIGTFGSFIGFSFAFGQVLQINFIASGQSTAQASLHA
                     AQIAFLGPLLGSLSRIYGGKLADRIGGGRVTLAAFCAMLLATGILISASTFGDHLAGP
                     MPTATMVGYVIGFTALFILSGIGNGSVYKMIPSIFEARSHSLQISEAERRQWSRSMSG
                     ALIGLAGAVGALGGVGVNLALRESYLTSGTATSAFWAFGVFYLVASVLTWAIYVRRGL
                     KSAGELVPATTAPAGLAYV"
     misc_feature    complement(312789..314126)
                     /gene="narK3"
                     /locus_tag="Rv0261c"
                     /note="Nitrate/nitrite transporter NarK [Inorganic ion
                     transport and metabolism]; Region: NarK; COG2223"
                     /db_xref="CDD:225133"
     gene            complement(314309..314854)
                     /gene="aac"
                     /locus_tag="Rv0262c"
                     /db_xref="GeneID:886648"
     CDS             complement(314309..314854)
                     /gene="aac"
                     /locus_tag="Rv0262c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression[PMID:9159528]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:14532352]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 2'-N-acetyltransferase"
                     /protein_id="NP_214776.1"
                     /db_xref="GeneID:886648"
                     /translation="MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHT
                     LGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDA
                     VEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLP
                     IDISLDTSAELMCDWRAGDVW"
     misc_feature    complement(314462..314809)
                     /gene="aac"
                     /locus_tag="Rv0262c"
                     /note="N-Acyltransferase superfamily: Various enyzmes that
                     characteristicly catalyze the transfer of an acyl group to
                     a substrate; Region: NAT_SF; cl17182"
                     /db_xref="CDD:327402"
     misc_feature    complement(order(314564..314569,314597..314605))
                     /gene="aac"
                     /locus_tag="Rv0262c"
                     /note="Coenzyme A binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:173926"
     gene            complement(314864..315766)
                     /locus_tag="Rv0263c"
                     /db_xref="GeneID:886659"
     CDS             complement(314864..315766)
                     /locus_tag="Rv0263c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214777.1"
                     /db_xref="GeneID:886659"
                     /translation="MTTLEILRSGPLALVEDLGRAGLAHLGVGRSGAADRRSHTLANR
                     LVANPDDWATVEVTFGGFSARVRGGDVDIAVTGADTDPTVNGIMVGTNSIHHVRDGQV
                     ISLGTPRAGLRTYLAVRGGVCVEPVLGSRSYDVMSAIGPSPLRAGDVLPVGEHTDDYP
                     ELDQAPVAAIEEHLVELRVVPGPRDDWLVDPDALVHTIWMASNRSDRVGMRLQGRPLQ
                     HRWPDRQLPGEGVTRGAIQVPPNGLPVILGPDHPITGSYPVVGVITDEDIDKVAQIRP
                     GQYVRLHWARPRSRLPGQGVTQAW"
     misc_feature    complement(314867..315760)
                     /locus_tag="Rv0263c"
                     /note="Carboxyltransferase domain, subdomain A and B;
                     Region: CT_A_B; cl00865"
                     /db_xref="CDD:321217"
     gene            complement(315783..316415)
                     /locus_tag="Rv0264c"
                     /db_xref="GeneID:886646"
     CDS             complement(315783..316415)
                     /locus_tag="Rv0264c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214778.1"
                     /db_xref="GeneID:886646"
                     /translation="MDAALACTVLDYGDHALMLQCDSTADAMAWTDALRAAALPGVVD
                     IVAASRTVLVKLDAPRYQGVTRQRLRRLRVTPEAVAAADHRCDLVIDVVYDGPDLAEV
                     ARCTGLTTAAVINAHTATGWRAGFSGSAPGFAYLIDGDPSLRVPRRPERRTSMPPGSV
                     ALADGFSAIYPSQAPSDWQIIGHTDAVLWDVDRPQPALLTPGMWVQFRAA"
     misc_feature    complement(315786..316403)
                     /locus_tag="Rv0264c"
                     /note="Allophanate hydrolase subunit 1 [Amino acid
                     transport and metabolism]; Region: DUR1A; COG2049"
                     /db_xref="CDD:224960"
     gene            complement(316511..317503)
                     /locus_tag="Rv0265c"
                     /gene_synonym="fecB2"
                     /db_xref="GeneID:886650"
     CDS             complement(316511..317503)
                     /locus_tag="Rv0265c"
                     /gene_synonym="fecB2"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00013"
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter substrate-binding
                     lipoprotein"
                     /protein_id="YP_177705.1"
                     /db_xref="GeneID:886650"
                     /translation="MRQGCSRRGFLQVAEAAAATGLFAGCSSPKPPPGTPGGAAVTIT
                     HLFGQTVIKEPPKRVVSAGYTEQDDLLAVDVVPIAVTDWFGDQPFAVWPWAAPKLGGA
                     RPAVLNLDNGIQIDRIAALKPDLIVAINAGVDADTYQQLSAIAPTVAQSGGDAFFEPW
                     KDQARSIGQAVFAADRMRSLIEAVDQKFAAVAQRHPRWRGKKALLLQGRLWQGNVVAT
                     LAGWRTDFLNDMGLVIADSIKPFAVDQRGVIPRDHIKAVLDAADVLIWMTESPEDEKA
                     LLADPEIAASQATAQRRHIFTSKEQAGAIAFSSVLSYPVVAEQLPPQISQILGA"
     misc_feature    complement(316514..317458)
                     /locus_tag="Rv0265c"
                     /gene_synonym="fecB2"
                     /note="ABC-type Fe3+-hydroxamate transport system,
                     periplasmic component [Inorganic ion transport and
                     metabolism]; Region: FepB; COG0614"
                     /db_xref="CDD:223687"
     gene            complement(317525..321154)
                     /gene="oplA"
                     /locus_tag="Rv0266c"
                     /db_xref="GeneID:886642"
     CDS             complement(317525..321154)
                     /gene="oplA"
                     /locus_tag="Rv0266c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-oxoprolinase OplA"
                     /protein_id="NP_214780.1"
                     /db_xref="GeneID:886642"
                     /translation="MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDA
                     AVAGIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALRIAYQN
                     RPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGEKMRQAHADGIRAVAV
                     VCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRR
                     YINQVADQMRGVRLMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHV
                     IGFDMGGTSTDVSHYAGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYR
                     VGPDSAGADPGPACYRGGGPLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRG
                     FTDLAADIAARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHDVTRYALTTFGG
                     AGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTAMREQSVEIPLGPAAPQRLA
                     SVAESLERAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIPVQLAEIETMATAFESS
                     HRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETVRIYSNGLWRD
                     APLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAA
                     TRAGFEAGFEADPVLLEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALFDPDG
                     NLVANAPHIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGGTHLPDITVITPV
                     FNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAE
                     TRRLLTEAPFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDN
                     AEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQLDTNFNAP
                     TSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQA
                     ITGALFAALGVQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMTNS
                     RLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMTVSTLSGHRRV
                     RPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTS
                     ARRRR"
     misc_feature    complement(317549..321136)
                     /gene="oplA"
                     /locus_tag="Rv0266c"
                     /note="Hydantoinase B/oxoprolinase; Region:
                     Hydantoinase_B; cl19816"
                     /db_xref="CDD:327631"
     gene            321331..322722
                     /gene="narU"
                     /locus_tag="Rv0267"
                     /db_xref="GeneID:886644"
     CDS             321331..322722
                     /gene="narU"
                     /locus_tag="Rv0267"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="Belongs to the nark/NASA family of transporters."
                     /codon_start=1
                     /transl_table=11
                     /product="nitrite extrusion protein NarU"
                     /protein_id="NP_214781.1"
                     /db_xref="GeneID:886644"
                     /translation="MALTTAPAIDYALPRQQDEGDHWIDDWRPEDPVFWETIGRPIAR
                     RNLIFSIFAEHVGFSVWMLWSIVVVQMTAAAPGHPAASGWALSASQALCLVAVPSGVG
                     AFLRLPYTFAIPIFGGRNWTTVSAALLVIPCLLLAWAVSHPSLPFAVLVVIAATAGFG
                     GGNFASSMANISFFYPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGSGVALSRAG
                     LFFVPLAVAAAVCAFLFMNNLTEAKADVKPVWQSLRHADTWIMSLLYIGTFGSFIGYS
                     AAFPTLLKTVFGRGDIALGWAFLGAGIGSLVRPLGGKLADRIGGARITAASFVMLAAG
                     AAAALWSVQSVNLPVFFVSFMFLFVATGIGNGSSYRMISRIFQVKGEVAGGDPETMVN
                     MRRQAAGALGIISSIGAFGGFVVPLAYAWSKVHFGNIEPALHFYVAFFLALLVVTWYC
                     YLRRTTPMGQVGV"
     misc_feature    321424..322701
                     /gene="narU"
                     /locus_tag="Rv0267"
                     /note="Nitrate/nitrite transporter NarK [Inorganic ion
                     transport and metabolism]; Region: NarK; COG2223"
                     /db_xref="CDD:225133"
     gene            complement(322764..323273)
                     /locus_tag="Rv0268c"
                     /db_xref="GeneID:886647"
     CDS             complement(322764..323273)
                     /locus_tag="Rv0268c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214782.1"
                     /db_xref="GeneID:886647"
                     /translation="MGTRSKSRTRQLKQSNGCTATTSGASDRRRRARRRTAPAWLRED
                     EWLRHHLPHPPRQLSRCLHRRRRSACHHRYSRRTPKGGLPMTSSLVPISEARAHLSRL
                     VRESADDDVVLMNHGRPAAILISAERYESLMEELEDLRDRLSVHEREHVTMPLDKLGA
                     ELGVDIGRV"
     misc_feature    complement(322767..323027)
                     /locus_tag="Rv0268c"
                     /note="Antitoxin component YafN of the YafNO
                     toxin-antitoxin module, PHD/YefM family [Defense
                     mechanisms]; Region: StbD; COG2161"
                     /db_xref="CDD:225072"
     gene            complement(323338..324531)
                     /locus_tag="Rv0269c"
                     /db_xref="GeneID:886640"
     CDS             complement(323338..324531)
                     /locus_tag="Rv0269c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214783.1"
                     /db_xref="GeneID:886640"
                     /translation="MSRMAAPVSLDVHGRQVIVTHPGRVVFPAHNDRKGYTKFDLVRY
                     YLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPANRPDWVDVAELHYASGRSAA
                     EAVIHDAAGLAWVINLGCVDLNPHPVLAGDLDHPDELRVDLDPMPGVAWQRVVEVALV
                     VREVLEDYGLTAWPKTSGSRGFHVYARIAPCWSFPQVRLAAQTVAREVERRLPDAATS
                     RWWKEEREGVFVDFNQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMAT
                     VPSRLADIGDPWAGMDDAVGRLDRLLMLAEELGPPQKAQSAKPLIEIARAKTRAEAMA
                     ALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRIRINLQHVPADQRPPQEELIADY
                     SPWPR"
     misc_feature    complement(323548..324507)
                     /locus_tag="Rv0269c"
                     /note="Eukaryotic-type DNA primase [Replication,
                     recombination and repair]; Region: LigD; COG3285"
                     /db_xref="CDD:225823"
     misc_feature    complement(order(323782..323790,323812..323814,
                     323830..323832,323839..323841,323983..323985,
                     323989..323997,324001..324003,324100..324102,
                     324106..324108,324160..324162,324298..324300,
                     324304..324306))
                     /locus_tag="Rv0269c"
                     /note="nucleotide binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:240135"
     gene            324567..326249
                     /gene="fadD2"
                     /locus_tag="Rv0270"
                     /db_xref="GeneID:886637"
     CDS             324567..326249
                     /gene="fadD2"
                     /locus_tag="Rv0270"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00455"
                     /codon_start=1
                     /transl_table=11
                     /product="fatty-acid--CoA ligase FadD2"
                     /protein_id="NP_214784.1"
                     /db_xref="GeneID:886637"
                     /translation="MPNLTDLPGQAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGL
                     EPPLNYAALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAAHAVANG
                     LLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFSGPQIKEVSDREGAK
                     VIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSGSSDETLAELIAHSSTAPAPKAS
                     RRASIIILTSGTTGTPKGANRNTPPTLAPIGGILSHVPFKAGEVTLLPSPMFHALGYM
                     HAALAMFLGSTLVLRRRFKPALVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDL
                     SSLKIVFVSGSQLGAELATRALGDLGPVIYNMYGSTEVAFATIAGPKDLQFNPSTVGP
                     VVKGVTVKILDENGNEVPQGAVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSGDVGYFD
                     ERGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEAAAIGVDDKEFGARLRAFV
                     VKKPGADLDEDTIKQYVRDHLARYKVPREVIFLDELPRNPTGKVLKRELRKL"
     misc_feature    324606..326246
                     /gene="fadD2"
                     /locus_tag="Rv0270"
                     /note="acyl-CoA synthetase; Validated; Region: PRK07788"
                     /db_xref="CDD:236097"
     gene            complement(326266..328461)
                     /gene="fadE6"
                     /locus_tag="Rv0271c"
                     /db_xref="GeneID:886641"
     CDS             complement(326266..328461)
                     /gene="fadE6"
                     /locus_tag="Rv0271c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase FadE6"
                     /protein_id="NP_214785.1"
                     /db_xref="GeneID:886641"
                     /translation="MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENPPPYW
                     QAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSAIASALIAAHDP
                     QAKVLAELATGAAIAAYALDSGLTATRHGDVLVIRGEVRAVPAAAQASVLVLPVAIES
                     RDEWVVLRNDQLEIEAVKSLDPLRPIAHVRANAVDVSDDALLSNLTMTTAHALMSTLL
                     SAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMIADTERATAAVWDAAR
                     ALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCIQVHGGIGFTWEHDTNVYYRRALM
                     LAACFGRGSEYPQRVVDTATTAGMRPVDIDLDPSTEKLRAQIRAEVAALKAMPREPRT
                     VAIAEGGWVLPYLPKPWGRAASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGT
                     DNQKQRLLPPTFRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQ
                     YSQWGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLDDVFVP
                     DELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVRDYRFEGQFDQVAR
                     HRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAISKLLSMRTGQGYAEFAVSSFGT
                     DAVIGDTERLPGKWGEYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP"
     misc_feature    complement(327442..328461)
                     /gene="fadE6"
                     /locus_tag="Rv0271c"
                     /note="Acyl-CoA dehydrogenase related to the alkylation
                     response protein AidB [Lipid transport and metabolism];
                     Region: CaiA; COG1960"
                     /db_xref="CDD:224871"
     misc_feature    complement(326284..327363)
                     /gene="fadE6"
                     /locus_tag="Rv0271c"
                     /note="Putative acyl-CoA dehydrogenases similar to fadE6,
                     fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152"
                     /db_xref="CDD:173841"
     misc_feature    complement(order(326947..326949,326953..326955,
                     327025..327030,327043..327048,327052..327054))
                     /gene="fadE6"
                     /locus_tag="Rv0271c"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173841"
     misc_feature    complement(order(326296..326298,326329..326334,
                     326881..326883,327025..327027))
                     /gene="fadE6"
                     /locus_tag="Rv0271c"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173841"
     misc_feature    complement(326698..326700)
                     /gene="fadE6"
                     /locus_tag="Rv0271c"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173841"
     gene            complement(328575..329708)
                     /locus_tag="Rv0272c"
                     /db_xref="GeneID:886635"
     CDS             complement(328575..329708)
                     /locus_tag="Rv0272c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214786.1"
                     /db_xref="GeneID:886635"
                     /translation="MTGRAATPGVIREFVGLPSRTAGRAAAGGHPCQGLYHHSVGRKP
                     KVALIAAHYQIDFSEHYLAEYMAIRGIGFLGWNTRFRGFESSFLLDHALVDIGVGVRW
                     LREVQGVETVVLLGNSGGGSLMAAYQSQAVDPNVTPLDGMRPAAGVTELPAADAYVAA
                     AAHPGRPDVLTAWMDAAVIDENDPVATDPELDLFDERNGPPYSPEFISRYRSAQVKRN
                     HTITDWAESELKRVRAAGFSDRPFSVMRTWADPRMVDPSIEPTKRRPNQCYAGTPVKA
                     NRSAHGIAAACTLRGWLGMWSLRVAQTRAAPHLARITCPALVLNAEADTGIFPSDAQQ
                     IYDGLASSDKTQVSIDTDHYFTTPGARSEQADTIAKWIAKRWR"
     misc_feature    complement(328659..>328853)
                     /locus_tag="Rv0272c"
                     /note="alpha/beta hydrolase fold; Region: Abhydrolase_1;
                     cl26327"
                     /db_xref="CDD:331148"
     gene            complement(329705..330325)
                     /locus_tag="Rv0273c"
                     /db_xref="GeneID:886633"
     CDS             complement(329705..330325)
                     /locus_tag="Rv0273c"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214787.1"
                     /db_xref="GeneID:886633"
                     /translation="MPDFPTQRGRRTQAAIDAAARTVVVRNGILATTVADITAEAGRS
                     AASFYNYYDSKEAMVRQWALRFRDDANQRALSVIRHGLSDRERAYEAAAAHWYTYRNR
                     LAEAISVSQLAMVSDDFAQYWSEICQIPISFITETVKRAQAHGYCVGDDPQLMAEAIV
                     AMFNQFCYLQLSGKRSRRGQPDDQACIQTLANIYYRAIYSKEDSSN"
     misc_feature    complement(329837..330313)
                     /locus_tag="Rv0273c"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            330422..331003
                     /locus_tag="Rv0274"
                     /db_xref="GeneID:886631"
     CDS             330422..331003
                     /locus_tag="Rv0274"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00082"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214788.1"
                     /db_xref="GeneID:886631"
                     /translation="MIKPHNTNTEFELGGINHVALVCSDMARTVDFYSNILGMPLIKA
                     LDLPGGQGQHFFFDAGNGDCVAFFWFADAPDRVPGLSSPVAIPGIGDITSAVSTMNHL
                     AFHVPAERFDAYRQRLKDKGVRVGPVLNHDDSETQVSAVVHPGVYVRSFYFQDPDGIT
                     LEFACWTKEFTTSDAQAVPKTAADRRPPVAADR"
     misc_feature    330464..330910
                     /locus_tag="Rv0274"
                     /note="Glyoxalase/Bleomycin resistance protein/Dioxygenase
                     superfamily; Region: Glyoxalase; pfam00903"
                     /db_xref="CDD:307174"
     gene            complement(330933..331658)
                     /locus_tag="Rv0275c"
                     /db_xref="GeneID:886629"
     CDS             complement(330933..331658)
                     /locus_tag="Rv0275c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="YP_177706.1"
                     /db_xref="GeneID:886629"
                     /translation="MTRSDRPYRGVEAAERLATRRRQSLSAGLDLLGSDQHDIAELTI
                     RTICRRAGLSVRYFYESFTDKDEFVGRVFDWVVAELVATTQAAVTAVPAREQTRAGMA
                     NIVRTITADARVGRLLFSTQLANAVITRKRAESSALFAMLSGQHAVDTLHAPANDHVK
                     AVAHFAVGGVGQTISAWLAGDVRLDPDQLVDQLAALLDELTDPNLSRPRVAATAAKSG
                     ANDPQPPEVAGQPPSSARPARRS"
     misc_feature    complement(331056..331616)
                     /locus_tag="Rv0275c"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            331748..332668
                     /locus_tag="Rv0276"
                     /db_xref="GeneID:886627"
     CDS             331748..332668
                     /locus_tag="Rv0276"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214790.1"
                     /db_xref="GeneID:886627"
                     /translation="MAISLVAHQPIPHVERPMADPPRLQLARRRRSAAGPGGNEDSLM
                     GVALLAGPANVIMELAMPGVGYGVLESRVESGRLDRHPIKRARTTFTYVAVAVAGSDD
                     QKAAFRRAVNKVHAQVYSTPESPVSYHAFDPELQLWVAACLYKGGVDVYRTFVGEMDD
                     EEADHHYRAGMAMGTTLQVPPQMWPPDRAAFDRYWRQSLDRVHIDDVVRDYLYPIVAL
                     RIRGIALPGPLRRLSEGIALLITTGFLPQRFRDEMRLPWDATKQRRFDALMAVLRTVN
                     RLMPRFVREFPFNLMLWDLDRRMRRGRPLV"
     misc_feature    331748..332665
                     /locus_tag="Rv0276"
                     /note="Uncharacterized conserved protein, DUF2236 family
                     [Function unknown]; Region: COG3662"
                     /db_xref="CDD:226188"
     gene            complement(332708..333136)
                     /gene="vapC25"
                     /locus_tag="Rv0277c"
                     /db_xref="GeneID:886625"
     CDS             complement(332708..333136)
                     /gene="vapC25"
                     /locus_tag="Rv0277c"
                     /note="toxin, contains PIN domain"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease VapC25"
                     /protein_id="NP_214791.1"
                     /db_xref="GeneID:886625"
                     /translation="MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVW
                     ASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHLPTSPGPRHLVLLRKLCDEADAS
                     GDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI"
     misc_feature    complement(332714..333136)
                     /gene="vapC25"
                     /locus_tag="Rv0277c"
                     /note="toxin-antitoxin system PIN domain toxin; Region:
                     Mtu_PIN_fam; TIGR00028"
                     /db_xref="CDD:272863"
     misc_feature    complement(order(332759..332761,332813..332815,
                     333122..333124))
                     /gene="vapC25"
                     /locus_tag="Rv0277c"
                     /note="putative active site [active]"
                     /db_xref="CDD:189022"
     gene            complement(333160..333417)
                     /gene="vapB25"
                     /locus_tag="Rv0277A"
                     /pseudogene="unknown"
                     /db_xref="GeneID:14515902"
     misc_feature    complement(333160..333417)
                     /gene="vapB25"
                     /locus_tag="Rv0277A"
                     /note="part of toxin-antitoxin (TA) operon with Rv0277c"
                     /pseudogene="unknown"
     gene            complement(333437..336310)
                     /locus_tag="Rv0278c"
                     /db_xref="GeneID:886623"
     CDS             complement(333437..336310)
                     /locus_tag="Rv0278c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00583"
                     /codon_start=1
                     /transl_table=11
                     /product="PE-PGRS family protein PE_PGRS3"
                     /protein_id="YP_177707.1"
                     /db_xref="GeneID:886623"
                     /translation="MSFVIAAPEVIAAAATDLASLGSSISAANAAAAANTTALMAAGA
                     DEVSTAIAALFGAHGQAYQALSAQAQAFHAQFVQALTSGGGAYAAAEAAAVSPLLDPI
                     NEFFLANTGRPLIGNGANGAPGTGANGGDGGWLIGNGGAGGSGAAGVNGGAGGNGGAG
                     GNGGAGGLIGNGGAGGAGGVASSGIGGSGGAGGNAMLFGAGGAGGAGGGVVALTGGAG
                     GAGGAGGNAGLLFGAAGVGGAGGFTNGSALGGAGGAGGAGGLFATGGVGGSGGAGSSG
                     GAGGAGGAGGLFGAGGTGGHGGFADSSFGGVGGAGGAGGLFGAGGEGGSGGHSLVAGG
                     DGGAGGNAGMLALGAAGGAGGIGGDGGTLTAGGIGGAGGAGGNAGLLFGSGGSGGAGG
                     FGFADGGQGGPGGNAGTVFGSGGAGGNGGVGQGFAGGIGGAGGTPGLIGNGGNGGNGG
                     ASAVTGGNGGIGGTGVLIGNGGNGGSGGIGAGKAGVGGVSGLLLGLDGFNAPASTSPL
                     HTLQQNVLNVVNEPFQTLTGRPLIGNGANGTPGTGADGGAGGWLFGNGANGTPGTGAA
                     GGAGGWLFGNGGNGGHGATNTAATATGGAGGAGGILFGTGGNGGTGGIATGAGGIGGA
                     GGAGGVSLLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPA
                     GVGGAGGNGGLFANGGAGGAGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGG
                     LFGAGGTGGAAGSGGSGITTGGGGHGGNAGLLSLGASGGAGGSGGASSLAGGAGGTGG
                     NGALLFGFRGAGGAGGHGGAALTSIQQGGAGGAGGNGGLLFGSAGAGGAGGSGANALG
                     AGTGGTGGDGGHAGVFGNGGDGGCRRVWRRYRRQRWCRRQRRADRQRRQRRQRRQSRG
                     HARCRRHRRAAARRERTQRLAIAGRPATTRGVEGISCSPQMMP"
     misc_feature    complement(336065..336310)
                     /locus_tag="Rv0278c"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:279302"
     gene            complement(336560..339073)
                     /gene="PE_PGRS4"
                     /locus_tag="Rv0279c"
                     /db_xref="GeneID:886621"
     CDS             complement(336560..339073)
                     /gene="PE_PGRS4"
                     /locus_tag="Rv0279c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="PE-PGRS family protein PE_PGRS4"
                     /protein_id="YP_177708.1"
                     /db_xref="GeneID:886621"
                     /translation="MSFVIAAPEVIAAAATDLASLESSIAAANAAAAANTTALLAAGA
                     DEVSTAVAALFGAHGQAYQALSAQAQAFHAQFVQALTSGGGAYAAAEAAATSPLLAPI
                     NEFFLANTGRPLIGNGTNGAPGTGANGGDGGWLIGNGGAGGSGAAGVNGGAGGNGGAG
                     GLIGNGGAGGAGGRASTGTGGAGGAGGAAGMLFGAAGVGGPGGFAAAFGATGGAGGAG
                     GNGGLFADGGVGGAGGATDAGTGGAGGSGGNGGLFGAGGTGGPGGFGIFGGGAGGDGG
                     SGGLFGAGGTGGSGGTSIINVGGNGGAGGDAGMLSLGAAGGAGGSGGSNPDGGGGAGG
                     IGGDGGTLFGSGGAGGVCGLGFDAGGAGGAGGKAGLLIGAGGAGGAGGGSFAGAGGTG
                     GAGGAPGLVGNAGNGGNGGASANGAGAAGGAGGSGVLIGNGGNGGSGGTGAPAGTAGA
                     GGLGGQLLGRDGFNAPASTPLHTLQQQILNAINEPTQALTGRPLIGNGANGTPGTGAD
                     GGAGGWLFGNGGNGGHGATGADGGDGGSGGAGGILSGIGGTGGSGGIGTTGQGGTGGT
                     GGAALLIGSGGTGGSGGFGLDTGGAGGRGGDAGLFLGAAGTGGQAALSQNFIGAGGTA
                     GAGGTGGLFANGGAGGAGGFGANGGTGGNGLLFGAGGTGGAGTLGADGGAGGHGGLFG
                     AGGTGGAGGSSGGTFGGNGGSGGNAGLLALGASGGAGGSGGSALNVGGTGGVGGNGGS
                     GGSLFGFGGAGGTGGSSGIGSSGGTGGDGGTAGVFGNGGDGGAGGFGADTGGNSSSVP
                     NAVLIGNGGNGGNGGKAGGTPGAGGTSGLIIGENGLNGL"
     misc_feature    complement(338828..339073)
                     /gene="PE_PGRS4"
                     /locus_tag="Rv0279c"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:279302"
     gene            339364..340974
                     /gene="PPE3"
                     /locus_tag="Rv0280"
                     /db_xref="GeneID:886619"
     CDS             339364..340974
                     /gene="PPE3"
                     /locus_tag="Rv0280"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE3"
                     /protein_id="YP_177709.1"
                     /db_xref="GeneID:886619"
                     /translation="MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAEYAAVAD
                     ELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAAARHETVAAAYTTAV
                     AAMPTLVELAANHTLHGVLVATNFFGINTIPIALNEADYARMWTQAASTMATYQAVAE
                     AAVASAPQTTPAPPILAAEAADDDHDHDHDHGGEPTPLDYLVAEILRIISGGRLIWDP
                     AEGTMNGIPFEDYTDAAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFD
                     YPTHIVQIVEALSQSPQLLAVALGSVISNLGAVTGFAGLSGLAGMQPAAIPALAPVAA
                     APSTLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPAPPPAPGAAGFGYPYAI
                     APPGIGFGSGMSASASAQRKAPQPDSAAAAAAAAAVRDQARARRRRRVTRRGYGDEFM
                     DMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLGFAGTARREAVADAAGMTTLAGDDFG
                     DGPTTPMVPGSWDPDRDAPGSAEPGDRG"
     misc_feature    339373..340935
                     /gene="PPE3"
                     /locus_tag="Rv0280"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     gene            340998..341906
                     /locus_tag="Rv0281"
                     /db_xref="GeneID:886618"
     CDS             340998..341906
                     /locus_tag="Rv0281"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosylmethionine-dependent
                     methyltransferase"
                     /protein_id="NP_214795.1"
                     /db_xref="GeneID:886618"
                     /translation="MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAF
                     CRAVGGSWADVLDGKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAAAAGARQVVI
                     LAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHGAQPRALRREIAVDLRDDW
                     PQALRDSGFDAAAPSAWIAEGLLIYLPATAQERLFTGIDALAGRRSHVAVEDGAPMGP
                     DEYAAKVEEERAAIAEGAEEHPFFQLVYNERCAPAAEWFGERGWTAVATLLNDYLEAV
                     GRPVPGPESEAGPMFARNTLVSAARV"
     misc_feature    340998..341900
                     /locus_tag="Rv0281"
                     /note="O-Methyltransferase involved in polyketide
                     biosynthesis [Secondary metabolites biosynthesis,
                     transport and catabolism]; Region: YktD; COG3315"
                     /db_xref="CDD:225852"
     gene            342130..344025
                     /gene="eccA3"
                     /locus_tag="Rv0282"
                     /db_xref="GeneID:886613"
     CDS             342130..344025
                     /gene="eccA3"
                     /locus_tag="Rv0282"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="ESX-3 secretion system protein EccA"
                     /protein_id="NP_214796.1"
                     /db_xref="GeneID:886613"
                     /translation="MAGVGEGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATC
                     CRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRT
                     ATTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKA
                     NHVVSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKIT
                     LGTALARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYA
                     AHPENEQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALL
                     HEAELQLAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKT
                     TIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEA
                     YALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTR
                     NIDFPSYTSHELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSL
                     DIAGNGRFVRNIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRG
                     LGLSVRA"
     misc_feature    342331..343998
                     /gene="eccA3"
                     /locus_tag="Rv0282"
                     /note="type VII secretion AAA-ATPase EccA; Region:
                     T7SS_EccA; TIGR03922"
                     /db_xref="CDD:188437"
     gene            344022..345638
                     /gene="eccB3"
                     /locus_tag="Rv0283"
                     /db_xref="GeneID:886645"
     CDS             344022..345638
                     /gene="eccB3"
                     /locus_tag="Rv0283"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="ESX-3 secretion system protein EccB3"
                     /protein_id="NP_214797.1"
                     /db_xref="GeneID:886645"
                     /translation="MTNQQHDHDFDHDRRSFASRTPVNNNPDKVVYRRGFVTRHQVTG
                     WRFVMRRIAAGIALHDTRMLVDPLRTQSRAVLMGVLIVITGLIGSFVFSLIRPNGQAG
                     SNAVLADRSTAALYVRVGEQLHPVLNLTSARLIVGRPVSPTTVKSTELDQFPRGNLIG
                     IPGAPERMVQNTSTDANWTVCDGLNAPSRGGADGVGVTVIAGPLEDTGARAAALGPGQ
                     AVLVDSGAGTWLLWDGKRSPIDLADHAVTSGLGLGADVPAPRIIASGLFNAIPEAPPL
                     TAPIIPDAGNPASFGVPAPIGAVVSSYALKDSGKTISDTVQYYAVLPDGLQQISPVLA
                     AILRNNNSYGLQQPPRLGADEVAKLPVSRVLDTRRYPSEPVSLVDVTRDPVTCAYWSK
                     PVGAATSSLTLLAGSALPVPDAVHTVELVGAGNGGVATRVALAAGTGYFTQTVGGGPD
                     APGAGSLFWVSDTGVRYGIDNEPQGVAGGGKAVEALGLNPPPVPIPWSVLSLFVPGPT
                     LSRADALLAHDTLVPDSRPARPVSAEGGYR"
     misc_feature    344130..345551
                     /gene="eccB3"
                     /locus_tag="Rv0283"
                     /note="type VII secretion protein EccB, Actinobacterial;
                     Region: T7SS_EccB; TIGR03919"
                     /db_xref="CDD:274854"
     gene            345635..349627
                     /gene="eccC3"
                     /locus_tag="Rv0284"
                     /db_xref="GeneID:886611"
     CDS             345635..349627
                     /gene="eccC3"
                     /locus_tag="Rv0284"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="ESX-3 secretion system protein EccC3"
                     /protein_id="NP_214798.1"
                     /db_xref="GeneID:886611"
                     /translation="MSRLIFEARRRLAPPSSHQGTIIIEAPPELPRVIPPSLLRRALP
                     YLIGILIVGMIVALVATGMRVISPQTLFFPFVLLLAATALYRGNDKKMRTEEVDAERA
                     DYLRYLSVVRDNIRAQAAEQRASALWSHPDPTALASVPGSRRQWERDPHDPDFLVLRA
                     GRHTVPLATTLRVNDTADEIDLEPVSHSALRSLLDTQRSIGDVPTGIDLTKVSPITVL
                     GERAQVRAVLRAWIAQAVTWHDPTVLGVALAARDLEGRDWNWLKWLPHVDIPGRLDAL
                     GPARNLSTDPDELIALLGPVLADRPAFTGQPTDALRHLLIVVDDPDYDLGASPLAVGR
                     AGVTVVHCSASAPHREQYSDPEKPILRVAHGAIERWQTGGWQPYIDAADQFSADEAAH
                     LARRLSRWDSNPTHAGLRSAATRGASFTTLLGIEDASRLDVPALWAPRRRDEELRVPI
                     GVTGTGEPLMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSAERLIVI
                     YADFKGEAGADSFRDFPQVVAVISNMAEKKSLADRFADTLRGEVARREMLLREAGRKV
                     QGSAFNSVLEYENAIAAGHSLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSF
                     RIHILFASQTLDVGKIKDIDKNTAYRIGLKVASPSVSRQIIGVEDAYHIESGKEHKGV
                     GFLVPAPGATPIRFRSTYVDGIYEPPQTAKAVVVQSVPEPKLFTAAAVEPDPGTVIAD
                     TDEQEPADPPRKLIATIGEQLARYGPRAPQLWLPPLDETIPLSAALARAGVGPRQWRW
                     PLGEIDRPFEMRRDPLVFDARSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPHEVS
                     FYCLDYGGGQLRALQDLAHVGSVASALEPERIRRTFGELEQLLLSRQQREVFRDRGAN
                     GSTPDDGFGEVFLVIDNLYGFGRDNTDQFNTRNPLLARVTELVNVGLAYGIHVIITTP
                     SWLEVPLAMRDGLGLRLELRLHDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHF
                     LFAAPELDAQTNPVAAINARYPGMAAPPVRLLPTNLAPHAVGELYRGPDQLVIGQREE
                     DLAPVILDLAANPLLMVFGDARSGKTTLLRHIIRTVREHSTADRVAFTVLDRRLHLVD
                     EPLFPDNEYTANIDRIIPAMLGLANLIEARRPPAGMSAAELSRWTFAGHTHYLIIDDV
                     DQVPDSPAMTGPYIGQRPWTPLIGLLAQAGDLGLRVIVTGRATGSAHLLMTSPLLRRF
                     NDLQATTLMLAGNPADSGKIRGERFARLPAGRAILLTDSDSPTYVQLINPLVDAAAVS
                     GETQQKGSQS"
     misc_feature    345740..347749
                     /gene="eccC3"
                     /locus_tag="Rv0284"
                     /note="type VII secretion protein EccCa; Region:
                     T7SS_EccC_a; TIGR03924"
                     /db_xref="CDD:274858"
     misc_feature    347888..349561
                     /gene="eccC3"
                     /locus_tag="Rv0284"
                     /note="DNA segregation ATPase FtsK/SpoIIIE and related
                     proteins [Cell cycle control, cell division, chromosome
                     partitioning]; Region: FtsK; cl28087"
                     /db_xref="CDD:332908"
     gene            349624..349932
                     /gene="PE5"
                     /locus_tag="Rv0285"
                     /db_xref="GeneID:886608"
     CDS             349624..349932
                     /gene="PE5"
                     /locus_tag="Rv0285"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="PE family protein PE5"
                     /protein_id="YP_177710.1"
                     /db_xref="GeneID:886608"
                     /translation="MTLRVVPEGLAAASAAVEALTARLAAAHASAAPVITAVVPPAAD
                     PVSLQTAAGFSAQGVEHAVVTAEGVEELGRAGVGVGESGASYLAGDAAAAATYGVVGG
                     "
     misc_feature    349630..349887
                     /gene="PE5"
                     /locus_tag="Rv0285"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:307197"
     gene            349935..351476
                     /gene="PPE4"
                     /locus_tag="Rv0286"
                     /db_xref="GeneID:886607"
     CDS             349935..351476
                     /gene="PPE4"
                     /locus_tag="Rv0286"
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE4"
                     /protein_id="YP_177711.1"
                     /db_xref="GeneID:886607"
                     /translation="MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYAST
                     AAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTT
                     ALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAA
                     SGAALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQL
                     IWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSP
                     FLLPAGLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAG
                     AATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVP
                     AAAAAAATRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLG
                     FAGTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGL
                     PHDSK"
     misc_feature    349956..350408
                     /gene="PPE4"
                     /locus_tag="Rv0286"
                     /note="PPE family; Region: PPE; pfam00823"
                     /db_xref="CDD:307116"
     gene            351525..351818
                     /gene="esxG"
                     /locus_tag="Rv0287"
                     /gene_synonym="TB9.8"
                     /db_xref="GeneID:886604"
     CDS             351525..351818
                     /gene="esxG"
                     /locus_tag="Rv0287"
                     /gene_synonym="TB9.8"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /codon_start=1
                     /transl_table=11
                     /product="ESAT-6 like protein EsxG"
                     /protein_id="NP_214801.1"
                     /db_xref="GeneID:886604"
                     /translation="MSLLDAHIPQLVASQSAFAAKAGLMRHTIGQAEQAAMSAQAFHQ
                     GESSAAFQAAHARFVAAAAKVNTLLDVAQANLGEAAGTYVAADAAAASTYTGF"
     gene            351848..352138
                     /gene="esxH"
                     /locus_tag="Rv0288"
                     /gene_synonym="cfp7; TB10.4"
                     /db_xref="GeneID:886603"
     CDS             351848..352138
                     /gene="esxH"
                     /locus_tag="Rv0288"
                     /gene_synonym="cfp7; TB10.4"
                     /experiment="DESCRIPTION:Gene expression[PMID:10603390]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927). Predicted possible vaccine candidate (See
                     Zvi et al.,2008)."
                     /codon_start=1
                     /transl_table=11
                     /product="ESAT-6-like protein EsxH"
                     /protein_id="NP_214802.1"
                     /db_xref="GeneID:886603"
                     /translation="MSQIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQ
                     GDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAMMARDTAEAAKWGG"
     misc_feature    351848..352135
                     /gene="esxH"
                     /locus_tag="Rv0288"
                     /gene_synonym="cfp7; TB10.4"
                     /note="Uncharacterized conserved protein YukE [Function
                     unknown]; Region: YukE; COG4842"
                     /db_xref="CDD:227179"
     gene            352149..353036
                     /gene="espG3"
                     /locus_tag="Rv0289"
                     /db_xref="GeneID:886602"
     CDS             352149..353036
                     /gene="espG3"
                     /locus_tag="Rv0289"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="ESX-3 secretion-associated protein EspG3"
                     /protein_id="NP_214803.1"
                     /db_xref="GeneID:886602"
                     /translation="MDATPNAVELTVDNAWFIAETIGAGTFPWVLAITMPYSDAAQRG
                     AFVDRQRDELTRMGLLSPQGVINPAVADWIKVVCFPDRWLDLRYVGPASADGACELLR
                     GIVALRTGTGKTSNKTGNGVVALRNAQLVTFTAMDIDDPRALVPILGVGLAHRPPARF
                     DEFSLPTRVGARADERLRSGVPLGEVVDYLGIPASARPVVESVFSGPRSYVEIVAGCN
                     RDGRHTTTEVGLSIVDTSAGRVLVSPSRAFDGEWVSTFSPGTPFAIAVAIQTLTACLP
                     DGQWFPGQRVSRDFSTQSS"
     misc_feature    352179..352955
                     /gene="espG3"
                     /locus_tag="Rv0289"
                     /note="EspG family; Region: ESX-1_EspG; pfam14011"
                     /db_xref="CDD:316524"
     gene            353083..354501
                     /gene="eccD3"
                     /locus_tag="Rv0290"
                     /db_xref="GeneID:886599"
     CDS             353083..354501
                     /gene="eccD3"
                     /locus_tag="Rv0290"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="ESX-3 secretion system protein EccD"
                     /protein_id="NP_214804.1"
                     /db_xref="GeneID:886599"
                     /translation="MSGTVMQIVRVAILADSRLTEMALPAELPLREILPAVQRLVVPS
                     AQNGDGGQADSGAAVQLSLAPVGGQPFSLDASLDTVGVVDGDLLVLQPVPAGPAAPGI
                     VEDIADAAMIFSTSRLKPWGIAHIQRGALAAVIAVALLATGLTVTYRVATGVLAGLLA
                     VAGIAVASALAGLLITIRSPRSGIALSIAALVPIGAALALAVPGKFGPAQVLLGAAGV
                     AAWSLIALMIPSAERERVVAFFTAAAVVGASVALAAGAQLLWQLPLLSIGCGLIVAAL
                     LVTIQAAQLSALWARFPLPVIPAPGDPTPSAPPLRLLEDLPRRVRVSDAHQSGFIAAA
                     VLLSVLGSVAIAVRPEALSVVGWYLVAATAAAATLRARVWDSAACKAWLLAQPYLVAG
                     VLLVFYTATGRYVAAFGAVLVLAVLMLAWVVVALNPGIASPESYSLPLRRLLGLVAAG
                     LDVSLIPVMAYLVGLFAWVLNR"
     misc_feature    353113..354495
                     /gene="eccD3"
                     /locus_tag="Rv0290"
                     /note="type VII secretion integral membrane protein EccD;
                     Region: T7SS_EccD; TIGR03920"
                     /db_xref="CDD:274855"
     gene            354498..355883
                     /gene="mycP3"
                     /locus_tag="Rv0291"
                     /db_xref="GeneID:886615"
     CDS             354498..355883
                     /gene="mycP3"
                     /locus_tag="Rv0291"
                     /experiment="DESCRIPTION:Gene expression[PMID:10974545]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00137"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane-anchored mycosin MycP"
                     /protein_id="NP_214805.1"
                     /db_xref="GeneID:886615"
                     /translation="MIRAAFACLAATVVVAGWWTPPAWAIGPPVVDAAAQPPSGDPGP
                     VAPMEQRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQLVAIIDTGVQPGP
                     RLPNVDAGGDFVESTDGLTDCDGHGTLVAGIVAGQPGNDGFSGVAPAARLLSIRAMST
                     KFSPRTSGGDPQLAQATLDVAVLAGAIVHAADLGAKVINVSTITCLPADRMVDQAALG
                     AAIRYAAVDKDAVIVAAAGNTGASGSVSASCDSNPLTDLSRPDDPRNWAGVTSVSIPS
                     WWQPYVLSVASLTSAGQPSKFSMPGPWVGIAAPGENIASVSNSGDGALANGLPDAHQK
                     LVALSGTSYAAGYVSGVAALVRSRYPGLNATEVVRRLTATAHRGARESSNIVGAGNLD
                     AVAALTWQLPAEPGGGAAPAKPVADPPVPAPKDTTPRNVAFAGAAALSVLVGLTAATV
                     AIARRRREPTE"
     misc_feature    354720..355868
                     /gene="mycP3"
                     /locus_tag="Rv0291"
                     /note="type VII secretion-associated serine protease
                     mycosin; Region: T7SS_mycosin; TIGR03921"
                     /db_xref="CDD:274856"
     gene            355880..356875
                     /gene="eccE3"
                     /locus_tag="Rv0292"
                     /db_xref="GeneID:886601"
     CDS             355880..356875
                     /gene="eccE3"
                     /locus_tag="Rv0292"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="ESX-3 secretion system protein EccE"
                     /protein_id="NP_214806.1"
                     /db_xref="GeneID:886601"
                     /translation="MNPIPSWPGRGRVTLVLLAVVPVALAYPWQSTRDYVLLGVAAAV
                     VIGLFGFWRGLYFTTIARRGLAILRRRRRIAEPATCTRTTVLVWVGPPASDTNVLPLT
                     LIARYLDRYGIRADTIRITSRVTASGDCRTWVGLTVVADDNLAALQARSARIPLQETA
                     QVAARRLADHLREIGWEAGTAAPDEIPALVAADSRETWRGMRHTDSDYVAAYRVSANA
                     ELPDTLPAIRSRPAQETWIALEIAYAAGSSTRYTVAAACALRTDWRPGGTAPVAGLLP
                     QHGNHVPALTALDPRSTRRLDGHTDAPADLLTRLHWPTPTAGAHRAPLTNAVSRT"
     misc_feature    355910..356764
                     /gene="eccE3"
                     /locus_tag="Rv0292"
                     /note="type VII secretion protein EccE; Region: T7SS_EccE;
                     TIGR03923"
                     /db_xref="CDD:274857"
     gene            complement(356862..358064)
                     /locus_tag="Rv0293c"
                     /db_xref="GeneID:886594"
     CDS             complement(356862..358064)
                     /locus_tag="Rv0293c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214807.1"
                     /db_xref="GeneID:886594"
                     /translation="MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVE
                     SSAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSF
                     PAPTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQ
                     HWRHRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFS
                     PFSGFGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLAS
                     VESRLEAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYR
                     PLLPKDRRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTV
                     FLQGLMFD"
     misc_feature    complement(<357042..357557)
                     /locus_tag="Rv0293c"
                     /note="alpha/beta hydrolase fold; Region: Abhydrolase_1;
                     cl26327"
                     /db_xref="CDD:331148"
     gene            358171..358956
                     /gene="tam"
                     /locus_tag="Rv0294"
                     /db_xref="GeneID:886593"
     CDS             358171..358956
                     /gene="tam"
                     /locus_tag="Rv0294"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="trans-aconitate methyltransferase"
                     /protein_id="NP_214808.1"
                     /db_xref="GeneID:886593"
                     /translation="MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLT
                     RYLARRWPGAVIEALDSSPEMVAAAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWV
                     PEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGA
                     VVQSPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDESWQ
                     QFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG"
     misc_feature    358171..358935
                     /gene="tam"
                     /locus_tag="Rv0294"
                     /note="trans-aconitate 2-methyltransferase; Provisional;
                     Region: PRK14103"
                     /db_xref="CDD:184509"
     misc_feature    order(358276..358296,358348..358353,358405..358413,
                     358456..358458)
                     /gene="tam"
                     /locus_tag="Rv0294"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:100107"
     gene            complement(358945..359748)
                     /locus_tag="Rv0295c"
                     /db_xref="GeneID:886596"
     CDS             complement(358945..359748)
                     /locus_tag="Rv0295c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214809.1"
                     /db_xref="GeneID:886596"
                     /translation="MSRAVRPYLVLATQRSGSTLLVESLRATGCAGEPQEFFQYLPST
                     GMAPQPREWFAGVDDDTILQLLDPLDPGTPDTATPVAWREHVRTSGRTPNGVWGGKLM
                     WNQTALLQQRAAQLPDRSGDGLRAAIRDVIGNEPVFVHVHRPDVVSQAVSFWRAVQTQ
                     VWRGHPDPKRDSQAVYHAGAIAHIIRNLRDQENGWRAWFAEEGIDPIDIAYPVLWRNL
                     TAIVASVLDAIGQDPKLAPAPMLERQANQRSDEWVDRYRAEAPRLGLPT"
     misc_feature    complement(358948..359748)
                     /locus_tag="Rv0295c"
                     /note="LPS sulfotransferase NodH [Cell
                     wall/membrane/envelope biogenesis]; Region: LpsS; COG4424"
                     /db_xref="CDD:226848"
     gene            complement(359758..361155)
                     /locus_tag="Rv0296c"
                     /gene_synonym="atsG"
                     /db_xref="GeneID:886600"
     CDS             complement(359758..361155)
                     /locus_tag="Rv0296c"
                     /gene_synonym="atsG"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00523"
                     /codon_start=1
                     /transl_table=11
                     /product="sulfatase"
                     /protein_id="YP_177712.1"
                     /db_xref="GeneID:886600"
                     /translation="MTSERATGQRENLLIVHWHDLGRYLGVYHHPDVYSPRLDRLAAE
                     GILFTRAHATAPLCTPSRGSLFTGRYPQSNGLVGLAHHGWEYRTGVQTLPQLLSESGW
                     YSALFGMQHETSYPKRLGFDEFDVSNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGF
                     FETHRPYPHERYRPADSAAVELPDYLPDTPEVRQDVAEFYGSIATADEAVGRLLDTLA
                     DTGLDASTWVVFVTDHGPAFPRAKSTLYDAGTGIALIIRPPTRRAMAPRVYDELFSGV
                     DLVPTLLDLLRLEVPADVEGVSHAPALLAPDTENAAVRDHVYTAKTYHDSFDPIRAIR
                     TKEYSYIENYAPRPLLDLPWDIQESPAGMAVAPLVKAPRPQRELYDLRADPTETNNLL
                     AGDDSTQGVAAIAADLAVRLHDWRQRTADVIPSDFAGSRIAERYTETYLRIHRKTPTG
                     RSAIAADRGIDEHCS"
     misc_feature    complement(359905..361122)
                     /locus_tag="Rv0296c"
                     /gene_synonym="atsG"
                     /note="N-sulfoglucosamine sulfohydrolase (SGSH;
                     sulfamidase); Region: SGSH; cd16027"
                     /db_xref="CDD:293751"
     misc_feature    complement(order(360454..360459,360664..360666,
                     360823..360825,360829..360831,360982..360984,
                     361096..361101))
                     /locus_tag="Rv0296c"
                     /gene_synonym="atsG"
                     /note="putative active site [active]"
                     /db_xref="CDD:293751"
     misc_feature    complement(order(360454..360456,360664..360666,
                     360823..360825,360829..360831,360982..360984,
                     361096..361101))
                     /locus_tag="Rv0296c"
                     /gene_synonym="atsG"
                     /note="putative substrate binding site [chemical binding];
                     other site"
                     /db_xref="CDD:293751"
     misc_feature    complement(order(360454..360459,360982..360984,
                     361096..361101))
                     /locus_tag="Rv0296c"
                     /gene_synonym="atsG"
                     /note="Ca binding site [ion binding]; other site"
                     /db_xref="CDD:293751"
     misc_feature    complement(order(360121..360126,360187..360189))
                     /locus_tag="Rv0296c"
                     /gene_synonym="atsG"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293751"
     gene            361334..363109
                     /gene="PE_PGRS5"
                     /locus_tag="Rv0297"
                     /db_xref="GeneID:885981"
     CDS             361334..363109
                     /gene="PE_PGRS5"
                     /locus_tag="Rv0297"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="PE-PGRS family protein PE_PGRS5"
                     /protein_id="YP_177713.1"
                     /db_xref="GeneID:885981"
                     /translation="MSFVIAQPEMIAAAAGELASIRSAINAANAAAAAQTTGVMSAAA
                     DEVSTAVAALFSSHAQAYQAASAQAAAFHAQVVRTLTVDAGAYASAEAANAGPNMLAA
                     VNAPAQALLGRPLIGNGANGAPGTGQAGGDGGLLFGNGGNGGSGAPGQAGGAGGAAGF
                     FGNGGNGGDGGAGANGGAGGTAGWFFGFGGNGGAGGIGVAGINGGLGGAGGDGGNAGF
                     FGNGGNGGMGGAGAAGVNAVNPGLATPVTPAANGGNGLNLVGVPGTAGGGADGANGSA
                     IGQAGGAGGDGGNASTSGGIGIAQTGGAGGAGGAGGDGAPGGNGGNGGSVEHTGATGS
                     SASGGNGATGGNGGVGAPGGAGGNGGHVSGGSVNTAGAGGKGGNGGTGGAGGPGGHGG
                     SVLSGPVGDSGNGGAGGDGGAGVSATDIAGTGGRGGNGGHGGLWIGNGGDGGAGGVGG
                     VGGAGAAGAIGGHGGDGGSVNTPIGGSEAGDGGKGGLGGDGGGRGIFGQFGAGGAGGA
                     GGVGGAGGAGGTGGGGGNGGAIFNAGTPGAAGTGGDGGVGGTGAAGGKGGAGGSGGVN
                     GATGADGAKGLDGATGGKGNNGNPG"
     misc_feature    361334..>361507
                     /gene="PE_PGRS5"
                     /locus_tag="Rv0297"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:307197"
     gene            363252..363479
                     /locus_tag="Rv0298"
                     /db_xref="GeneID:886590"
     CDS             363252..363479
                     /locus_tag="Rv0298"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="NP_214812.1"
                     /db_xref="GeneID:886590"
                     /translation="MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRV
                     ALRDYTAKTVPALDIDAYAQRVYQANRAAGS"
     gene            363476..363778
                     /locus_tag="Rv0299"
                     /db_xref="GeneID:886598"
     CDS             363476..363778
                     /locus_tag="Rv0299"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="toxin"
                     /protein_id="NP_214813.1"
                     /db_xref="GeneID:886598"
                     /translation="MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGR
                     VPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPLGNAGVAALREAASVVTALLC"
     gene            363826..364047
                     /gene="vapB2"
                     /locus_tag="Rv0300"
                     /db_xref="GeneID:886588"
     CDS             363826..364047
                     /gene="vapB2"
                     /locus_tag="Rv0300"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:23011806]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="part of toxin-antitoxin (TA) operon with Rv0301.
                     This region is a possible MT-complex-specific genomic
                     island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin VapB2"
                     /protein_id="NP_214814.1"
                     /db_xref="GeneID:886588"
                     /translation="MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTAR
                     VTVTAADLRRLRGAVAGLGDPELMRQAWR"
     misc_feature    363850..>363927
                     /gene="vapB2"
                     /locus_tag="Rv0300"
                     /note="hypothetical protein; Region: PHA01748"
                     /db_xref="CDD:222832"
     gene            364044..364469
                     /gene="vapC2"
                     /locus_tag="Rv0301"
                     /db_xref="GeneID:886586"
     CDS             364044..364469
                     /gene="vapC2"
                     /locus_tag="Rv0301"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:23011806]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="toxin, part of toxin-antitoxin (TA) operon with
                     Rv0300, contains PIN domain. This region is a possible
                     MT-complex-specific genomic island (See Becq et al., 2007
                     PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease VapC2"
                     /protein_id="NP_214815.1"
                     /db_xref="GeneID:886586"
                     /translation="MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEV
                     GFSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLI
                     AATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA"
     misc_feature    364062..364442
                     /gene="vapC2"
                     /locus_tag="Rv0301"
                     /note="PIN domain of the Rv0301 toxin of Mycobacterium
                     tuberculosis and other uncharacterized, annotated PilT
                     protein domain proteins; Region: PIN_MtRv0301; cd09882"
                     /db_xref="CDD:189052"
     misc_feature    order(364068..364070,364170..364172,364338..364340,
                     364392..364394)
                     /gene="vapC2"
                     /locus_tag="Rv0301"
                     /note="putative active site [active]"
                     /db_xref="CDD:189052"
     gene            364605..365237
                     /locus_tag="Rv0302"
                     /db_xref="GeneID:886584"
     CDS             364605..365237
                     /locus_tag="Rv0302"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214816.1"
                     /db_xref="GeneID:886584"
                     /translation="MGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDIRDAC
                     GLAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQ
                     SQHPDFLRLFYLLSMERSQDPAVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLV
                     VAELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET"
     misc_feature    364614..365216
                     /locus_tag="Rv0302"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            365234..366142
                     /locus_tag="Rv0303"
                     /db_xref="GeneID:886581"
     CDS             365234..366142
                     /locus_tag="Rv0303"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="dehydrogenase/reductase"
                     /protein_id="NP_214817.1"
                     /db_xref="GeneID:886581"
                     /translation="MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRA
                     AMEELGEPNRCSVLEVDLASVRSVRSFVETVRTTPLPPIRALVCNAGLQVVSGIAFTD
                     DGVEMTFGVNHLGHFALVTGILDWLARPARIVVVSSGTHDPSKHTGMPDPRYTCAADL
                     AHPPTDQNTPAEGRRRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLA
                     RDYPPILRLAYRLLSPMLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIR
                     SSAESYDRAKALDLWETSERLLAQVT"
     misc_feature    365240..366133
                     /locus_tag="Rv0303"
                     /note="light-dependent protochlorophyllide reductase
                     (LPOR)-like, classical (c)-like SDRs; Region:
                     LPOR_like_SDR_c_like; cd09810"
                     /db_xref="CDD:187670"
     misc_feature    order(365261..365263,365267..365278,365339..365347,
                     365411..365419,365498..365506,365564..365566,
                     365657..365665,365762..365764,365774..365776,
                     365858..365869,365873..365878)
                     /locus_tag="Rv0303"
                     /note="putative NAD(P) binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187670"
     misc_feature    order(365567..365569,365663..365665,365762..365764,
                     365774..365776)
                     /locus_tag="Rv0303"
                     /note="active site"
                     /db_xref="CDD:187670"
     gene            complement(366150..372764)
                     /gene="PPE5"
                     /locus_tag="Rv0304c"
                     /db_xref="GeneID:886592"
     CDS             complement(366150..372764)
                     /gene="PPE5"
                     /locus_tag="Rv0304c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE5"
                     /protein_id="YP_177714.1"
                     /db_xref="GeneID:886592"
                     /translation="MNLVSTTSGMSGFLNVGALGSGVANVGNTISGIYNVGTSDLSTP
                     AVNSGLANIGTNIAGLLRDGAGTAAINLGLANHGNLNVGFASLGGFNFGGATIGHNNV
                     GIGNTGIFDVGLANLGSYNIGFGNLGDDNLGFGNFGSYNIGFGNVGNDNLGFANAGGG
                     NIGFANTGSNNVGFGNTGSNNVGIGLTGNGQIGFGSFNSGSGNIGLFNSGSNNIGFFN
                     SGSGNFGIANSGSFNTGIGNTGNTNTGLFNSGDVNTGAFNPGSFNTGSFNTGSFNTGG
                     FNPGNTNTGYLNIGNYNTGIANTGDVDTGAFITGNYSNGLFLSGDYQGLVGLNLVIDM
                     PLPISLGVNIPIDIPITASAGNITLMGVTIPPTGDIVLSSIAGQRAHFGPITIPNITV
                     VGPTTTVAIGGPNTAITITGGGAIRIPLISIPAAPGFGNSTTNPSSGFFNTGAGGASG
                     FGNFGGANSGFWNLASATSGASGLLNVGALGSGLANVGTTVSGFYNTSTSDLATPAFN
                     SGLANISTSIAGLLRDSTGTMVLNLGLANHGTLNVGIANLGDYNIGFANLGSANFGSA
                     NIGGNNIGGANTGIFDIGLANLGSYNIGFGNFGDDNLGFGNLGSYNVGFGNLGNDNLG
                     FANTGSNNIGFANTGSNNIGIGLTGDGQIGFGSLNSGSGNIGLFNSGSGNIGFFNSGN
                     GNVGIGNTGTANFGLGNTGSTNTGFFNSGDVNTGIGNTGSFNTGSFNPGDSNTGDFNP
                     GSYNTGLGNTGDVDTGAFISGSYSNGFLWSGNYQGLIGLHAALAIPEIALTFGVDIPI
                     HIPINIDAGVVTLQGFSIVAAENNIDFTPIIIPTINITLPTAAITVGGPTTSIGITAS
                     AGIGSITIPIIDIPATSGFGNSTTSPSSGFFNSGAGSASGFLNVVAGASGISGYLNVG
                     ALGSGVTNVGHTVSGFYNASALDLVTPAFASGLMRDGMGTMTLNLGLANLGSNNAGFG
                     NTGIFDVGVANLGNYNIGFGNFGDDNLGFANLGSYNIGVANTGSNNIGFANTGSNNIG
                     IGLTGTGQIGIGALNSGSGNIGLFNSGDGNIGFFNSGTGNFGIGNTGTGNFGIGNSGS
                     TSTGLFNSGDGNTGGFNPGNFNTGNFNTGSFNTGGFNAGNTNTGHFNTGNYNTGIANT
                     GDVSTGAFISGNYSNGILWRGDYQGLIGYSYALTIPEIPAHLDVNIPIDIPITGSFTD
                     LVVDNFTIPIIGFESFAFSFHIHTEPDIGPIIVPSFVLSVPTFAIAVGGPTTAINISA
                     TAGLGPITIPIIDIPAAPGIGNSTTSPSSGFFNTGAGTASGFGNVGGNTSGLWNLASA
                     ASGVSGLLNVGALGSGVANVGNTISGIYNTSPLDLGTPAFGSGLANIAGLLQGGAGTT
                     ILDLAGLGNLNVGLANLGGSNFGIGNTGIFNVGFANVGNHNIGLANLGNYSVGFANSG
                     NYHIGIANTGSANIGFANTGSGNIGIGLTGTGQIGFGSFNSGSHNIGLFNSGDGNVGF
                     FNSGTGNVGIGNTGTANFGIANSGSFNTGLGNTGSTNTGLFNPGNVNTGVGNTGSINT
                     GSINTGSFNTGSTNTGSFNLGDHNTGSFNSGDYNTGYFNAGDYNTGVANTGNVNTGAF
                     ISGNYSNGFFWRGDYQGLIGLSTTITIPEIPYRYDLSVPIDIPITGTVVATTPNSFTI
                     PGFQIRVLLGPAAVLVNEMIGPITIDVNQVIAIDSPIQQTISMVGTGGFGPIPIGISI
                     GGTPGFGNSTTGPSSGFFHTGAGHVSGFGNFGAGNMSGSGNFGAGNSGFFNAGGLGNS
                     GLLNFGALQSGLANLGNTISGVYNTSTLDLATPAFGSGIANIGANLAGLFLDNTGNLT
                     LNFGVANQGGLNAGIGNLGSVNIGFVNTGDSNLGIGNLGDLNFGGVNIGGNNIGIANT
                     GIFDIGLANLGSYNIGLANLGDDNLGFGNAGSYNIGFANFGSDNLGFANTGSYNIGFA
                     NTGNNNIGVGLTGNGQIGIGSLNSGSNNIGLFNSGSGNIGFFNSGTGNVGIFNTGTGN
                     FGLANSGGFNTGIGNAGSTNTGVFNPGDLNTGSFNPGSFNTGGFNPGSGNTGYLNTGD
                     YNTGVANTGDVDTGAFITGSYSNGFLVSGDYQGLIGLPLLGIPVTPGYFNLTGGPSSG
                     FFNSGAGSVSGFVNSGAGLSGYLNTGALGSGVANVGNTISGWLNASALDLATPGFLSG
                     IGNFGTNLAGFFRG"
     misc_feature    complement(371802..>372686)
                     /gene="PPE5"
                     /locus_tag="Rv0304c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(370509..>371444)
                     /gene="PPE5"
                     /locus_tag="Rv0304c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(369261..370661)
                     /gene="PPE5"
                     /locus_tag="Rv0304c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(367893..>368852)
                     /gene="PPE5"
                     /locus_tag="Rv0304c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(366453..>367280)
                     /gene="PPE5"
                     /locus_tag="Rv0304c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     gene            complement(372820..375711)
                     /gene="PPE6"
                     /locus_tag="Rv0305c"
                     /db_xref="GeneID:885978"
     CDS             complement(372820..375711)
                     /gene="PPE6"
                     /locus_tag="Rv0305c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE6"
                     /protein_id="YP_177715.1"
                     /db_xref="GeneID:885978"
                     /translation="MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADELAVAASW
                     FGSVTSGLADAAWRGPAAVAMARAVAPYLGWLISATAQAEQAAAQARVAVATFEAARA
                     ATVHPAIVAANRAVLVSLVSSNLLGFNAPAIAATEAAYERMWAQDVAAMVGYHAGASA
                     AVSALMPFTQQLKKLAGLSERLTSAAAAAAGPPSAAGFNLGLANVGANNVGNGNVGVF
                     NVGFGNLGSYNLGFANLGSDNLGLANLGGHNIGFANTGSNNVGFGNTGSNNVGIGLTG
                     NGQIGFGSFNSGSHNIGLFNSGSGNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGW
                     FNTGDVNTGGFNPGSYNTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNT
                     GAFIAGNYSNGVLWRGDYQGLIGADIALEIPAIPINAQLFSMPIHQVMVMPGSVMTIP
                     GMRLPFTSIVPFVVYYGPVELPQSTLTLPTVTITVGGPTTTIDGNLTGMVGGVSIPLI
                     KIPAAPGFGNSTTSPSSGFFNAGAGTASGFGNFGGGASGFWNLASATSGLSGFGNVGA
                     LGSGVANVGNTISGLYNTSTSNLATPAFNSGLLHHSVGTMTLNFGLANVGGNNVGGAN
                     AGIFNVGLANLGDYNIGFGNLGGDNLGFAHAGSYNIGFANTGSNNLGFANTGDNNIGF
                     ANIGSNNIGIGLTGSGQIGFGSLNSGSHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTG
                     NWGIGNSGAGNFGIGNAGSTNTGLFNSGDLNTGSLNPGSYNTGSVNTGSVNTGGFNAG
                     NYNTGYFNTGDLQHRHGEHRQYQHRRFHLRQPQQRPSVAGRQPGSDRPRHRRRHSRNP
                     DCERRREYPDSHTDHRQLHGHRIQRARSSTEHSRHCYFFRTRRYRPLHRPSDTDNRSH
                     TCGHGGWTHYRDQYRRHCGRRRHQHPDYPYSSDSRLRQLDRRTVVGLLQ"
     misc_feature    complement(374485..375711)
                     /gene="PPE6"
                     /locus_tag="Rv0305c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(373285..>374130)
                     /gene="PPE6"
                     /locus_tag="Rv0305c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(<372847..373230)
                     /gene="PPE6"
                     /locus_tag="Rv0305c"
                     /note="Arginine/Serine-Rich protein 1; Region: RSRP;
                     pfam17069"
                     /db_xref="CDD:293674"
     gene            375914..376585
                     /locus_tag="Rv0306"
                     /db_xref="GeneID:886577"
     CDS             375914..376585
                     /locus_tag="Rv0306"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214820.1"
                     /db_xref="GeneID:886577"
                     /translation="MFSAPERRAVYRVIAERRDMRRFVPGGVVSEDVLARLLHAAHAA
                     PSVGLMQPWRFIRITDETLKRRIHALVDDERLLTAEALGAREEEFLALKVEGILDCAE
                     LLVVALCDRRGSYIFGRRTLPQMDLASVSCAIQNLWLAARSEGLGMGWVSLFDPQRLA
                     ALLAMPADAEPVAILCLGPVPEFPDRPALELDGWAYARPLAEFVSENRWSYPSALATD
                     HHHGE"
     misc_feature    375944..376525
                     /locus_tag="Rv0306"
                     /note="Proteins of this family catalyze the reduction of
                     flavin or nitrocompounds using NAD(P)H as electron donor
                     in a obligatory two-electron transfer, utilizing FMN or
                     FAD as cofactor. They are often found to be homodimers.
                     Enzymes of this family are...; Region:
                     Nitro_FMN_reductase; cl00514"
                     /db_xref="CDD:321015"
     misc_feature    order(375962..375964,375968..375970,375974..375976,
                     376055..376057,376367..376372)
                     /locus_tag="Rv0306"
                     /note="FMN binding site [chemical binding]; other site"
                     /db_xref="CDD:239015"
     misc_feature    order(376301..376303,376307..376312,376319..376324,
                     376331..376333)
                     /locus_tag="Rv0306"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239015"
     gene            complement(376573..377055)
                     /locus_tag="Rv0307c"
                     /db_xref="GeneID:886580"
     CDS             complement(376573..377055)
                     /locus_tag="Rv0307c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214821.1"
                     /db_xref="GeneID:886580"
                     /translation="MAVIVRKWFGLGRLPADLRCQVEAEGLIYLAEYVAVTRRFTGVI
                     PGLRASHSIASYVGALAFTEQRVLGTLSMVPKLAGRVVDARWDGPQAGAATAEISPTG
                     LQLDLDVADVDPKFSGQLALHFKATIGEDVLSRLPRRSLAFDVPAEYVNLAVGVTYSP
                     "
     gene            377113..377829
                     /locus_tag="Rv0308"
                     /db_xref="GeneID:886583"
     CDS             377113..377829
                     /locus_tag="Rv0308"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane protein"
                     /protein_id="NP_214822.1"
                     /db_xref="GeneID:886583"
                     /translation="MTRPQALLAVSLAFVATAVYAVMWVGHSQDWGWLHSFDWSLLNA
                     AHDIGIKNPAWVRFWDGVSLILGPVVLRPLGLLAAMVALAKRKIRIALLLLACLPLNA
                     IMTIAAKSVAHRPRPATALVSAHSTSFPSGHALEATASVLALLTVLLPMLHSRFTRHI
                     AITVGALCVLTVGVARVALNVHHPTDVVAGWALGYLYFLVCLCVFRPPSIFGAQRASH
                     ALSPPVEVSRQPEPEVDTAR"
     misc_feature    377203..377730
                     /locus_tag="Rv0308"
                     /note="PAP2_like_2 proteins. PAP2 is a super-family of
                     phosphatases and haloperoxidases. This subgroup, which is
                     specific to bacteria, lacks functional characterization
                     and may act as a membrane-associated lipid phosphatase;
                     Region: PAP2_like_2; cd03392"
                     /db_xref="CDD:239486"
     misc_feature    order(377437..377439,377458..377460,377503..377511,
                     377638..377640,377656..377658,377668..377670)
                     /locus_tag="Rv0308"
                     /note="active site"
                     /db_xref="CDD:239486"
     gene            377931..378587
                     /locus_tag="Rv0309"
                     /db_xref="GeneID:886574"
     CDS             377931..378587
                     /locus_tag="Rv0309"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214823.1"
                     /db_xref="GeneID:886574"
                     /translation="MSRLLALLCAAVCTGCVAVVLAPVSLAVVNPWFANSVGNATQVV
                     SVVGTGGSTAKMDVYQRTAAGWQPLKTGITTHIGSAGMAPEAKSGYPATPMGVYSLDS
                     AFGTAPNPGGGLPYTQVGPNHWWSGDDNSPTFNSMQVCQKSQCPFSTADSENLQIPQY
                     KHSVVMGVNKAKVPGKGSAFFFHTTDGGPTAGCVAIDDATLVQIIRWLRPGAVIAIAK
                     "
     misc_feature    377931..378584
                     /locus_tag="Rv0309"
                     /note="L,D-peptidoglycan transpeptidase YkuD,
                     ErfK/YbiS/YcfS/YnhG family [Cell wall/membrane/envelope
                     biogenesis]; Region: COG3786"
                     /db_xref="CDD:226309"
     gene            complement(378657..379148)
                     /locus_tag="Rv0310c"
                     /db_xref="GeneID:886570"
     CDS             complement(378657..379148)
                     /locus_tag="Rv0310c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214824.1"
                     /db_xref="GeneID:886570"
                     /translation="MCCNGVVTPGDPADIAAIKQLKYRYLRALDTKHWDDFTDTLAED
                     VTGDYGSSVGTELHFTNRADLVDYLRQALGPGVITEHRVTHPEITVTGDTATGIWYLQ
                     DRVIVAEFNFMLIGAAFYHDQYRRTTDGWRISATGYDRTYEATMSLAGLNFNIRPGRA
                     LAD"
     misc_feature    complement(378747..379112)
                     /locus_tag="Rv0310c"
                     /note="SnoaL-like domain; Region: SnoaL_4; pfam13577"
                     /db_xref="CDD:316133"
     gene            379172..380401
                     /locus_tag="Rv0311"
                     /db_xref="GeneID:886579"
     CDS             379172..380401
                     /locus_tag="Rv0311"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00881"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214825.1"
                     /db_xref="GeneID:886579"
                     /translation="MSQSRYAGLSRSELAVLLPELLLIGQLIDRSGMAWCIQAFGRQE
                     MLQIAIEEWAGASPIYTKRMQKALNFEGDDVPTIFKGLQLDIGAPPQFMDFRFTLHDR
                     WHGEFHLDHCGALLDVEPMGDDYVVGMCHTIEDPTFDATAIATNPRAQVRPIHRPPRK
                     PADRHPHCAWTVIIDESYPEAEGIPALDAVRETKAATWELDNVDASDDGLVDYSGPLV
                     SDLDFGAFSHSALVRMADEVCLQMHLLNLSFAIAVRKRAKADAQLAISVNTRQLIGVA
                     GLGAERIHRAMALPGGIEGALGVLELHPLLNPAGYVLAETSPDRLVVHNSPAHADGAW
                     ISLCTPASVQPLQAIATAVDPHLKVRISGTDTDWTAELIEADAPASELPEVLVAKVSR
                     GSVFQFEPRRSLPLTVK"
     gene            380556..382418
                     /locus_tag="Rv0312"
                     /db_xref="GeneID:886566"
     CDS             380556..382418
                     /locus_tag="Rv0312"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214826.1"
                     /db_xref="GeneID:886566"
                     /translation="MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPS
                     QNPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSE
                     IAIAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSV
                     VGLLDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGY
                     GDDVDPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDL
                     IQDPLTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQ
                     PGCAAAMGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDR
                     ELAWSQTDFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSA
                     VVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAP
                     LPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVT
                     TTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG"
     misc_feature    380565..>381566
                     /locus_tag="Rv0312"
                     /note="Molecular chaperone DnaK (HSP70) [Posttranslational
                     modification, protein turnover, chaperones]; Region: DnaK;
                     COG0443"
                     /db_xref="CDD:223520"
     gene            382490..382876
                     /locus_tag="Rv0313"
                     /db_xref="GeneID:886572"
     CDS             382490..382876
                     /locus_tag="Rv0313"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214827.1"
                     /db_xref="GeneID:886572"
                     /translation="MGDYGPFGFDPDEFDRVIREGSEGLRDAFERIGRFLSSSGAGTG
                     WSAIFEDLSRRSRPAPETAGEAGDGVWAIYTVDADGGARVEQVYATELDALRANKDNT
                     DPKRKVRFLPYGIAVSVLDDPVDEAQ"
     misc_feature    <382526..>382870
                     /locus_tag="Rv0313"
                     /note="Hsp90 protein; Region: HSP90; cl27733"
                     /db_xref="CDD:332554"
     gene            complement(382879..383541)
                     /locus_tag="Rv0314c"
                     /db_xref="GeneID:886564"
     CDS             complement(382879..383541)
                     /locus_tag="Rv0314c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214828.1"
                     /db_xref="GeneID:886564"
                     /translation="MIVVWEHLCMNPEDDPEARIRELERPLADVARASELGGSQSGGY
                     TYPPGPPPPPYSYGGPFGGPSPRSSSGNRAWWILAAVVVVGVLVLVGGIAAFSAQRLS
                     QGNFVVLSPTPSVSRAVPTPTAQPATTLPPAGASLSVSGVNVNRTIACNDSIVSVSGM
                     SNTVVITGHCTSLTVSGMRNSVTVDSVDTIEAAGFNNEVTYHSGSPKISNAGGSNSVQ
                     QG"
     misc_feature    complement(382906..383073)
                     /locus_tag="Rv0314c"
                     /note="Protein of unknown function (DUF3060); Region:
                     DUF3060; pfam11259"
                     /db_xref="CDD:314245"
     gene            383602..384486
                     /locus_tag="Rv0315"
                     /db_xref="GeneID:886563"
     CDS             383602..384486
                     /locus_tag="Rv0315"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS01034"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-1,3-glucanase"
                     /protein_id="NP_214829.1"
                     /db_xref="GeneID:886563"
                     /translation="MLMPEMDRRRMMMMAGFGALAAALPAPTAWADPSRPAAPAGPTP
                     APAAPAAATGGLLFHDEFDGPAGSVPDPSKWQVSNHRTPIKNPVGFDRPQFFGQYRDS
                     RQNVFLDGNSNLVLRATREGNRYFGGLVHGLWRGGIGTTWEARIKFNCLAPGMWPAWW
                     LSNDDPGRSGEIDLIEWYGNGTWPSGTTVHANPDGTAFETCPIGVDGGWHNWRVTWNP
                     SGMYFWLDYADGIEPYFSVPATGIEDLNEPIREWPFNDPGYKVFPVLNLAVGGSGGGD
                     PATGSYPQEMLVDWVRVF"
     misc_feature    383767..384483
                     /locus_tag="Rv0315"
                     /note="Beta-glucanase, GH16 family [Carbohydrate transport
                     and metabolism]; Region: BglS; COG2273"
                     /db_xref="CDD:225182"
     gene            384535..385149
                     /locus_tag="Rv0316"
                     /db_xref="GeneID:886560"
     CDS             384535..385149
                     /locus_tag="Rv0316"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="muconolactone isomerase"
                     /protein_id="NP_214830.1"
                     /db_xref="GeneID:886560"
                     /translation="MEFLVTMTTRVPDSMPADAVERVRAREAARSRELAAQGKLLRLW
                     RPPLRPGEWRTLGLFAADDNGELEQLLASMPPRSWRTDDVTPLGAHPNDPVGQGITIA
                     PGKGPEFLIATTIMVPPGTPAQVVDDTVAREARRAPELAGRGHLVRLWALPDGPDGQR
                     TLGLWRARDPGELMAILESLPLAGWMTIETTPLSPHPDDPIRMP"
     misc_feature    384535..384849
                     /locus_tag="Rv0316"
                     /note="Muconolactone delta-isomerase; Region: MIase;
                     cl01992"
                     /db_xref="CDD:321762"
     misc_feature    384856..385122
                     /locus_tag="Rv0316"
                     /note="Muconolactone delta-isomerase; Region: MIase;
                     pfam02426"
                     /db_xref="CDD:308176"
     gene            complement(385173..385943)
                     /gene="glpQ2"
                     /locus_tag="Rv0317c"
                     /db_xref="GeneID:886559"
     CDS             complement(385173..385943)
                     /gene="glpQ2"
                     /locus_tag="Rv0317c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphoryl diester phosphodiesterase
                     GlpQ"
                     /protein_id="NP_214831.1"
                     /db_xref="GeneID:886559"
                     /translation="MEFLRHGGRIAMAHRGFTSFRLPMNSMGAFQEAAKLGFRYIETD
                     VRATRDGVAVILHDRRLAPGVGLSGAVDRLDWRDVRKAQLGAGQSIPTLEDLLTALPD
                     MRVNIDIKAASAIEPTVNVIERCNAHNRVLIGSFSERRRRRALRLLTKRVASSAGTGA
                     LLAWLTARPLGSRAYAWRMMRDIDCVQLPSRLGGVPVITPARVRGFHAAGRQVHAWTV
                     DEPDVMHTLLDMDVDGIITDRADLLRDVLIARGEWDGA"
     misc_feature    complement(385203..385913)
                     /gene="glpQ2"
                     /locus_tag="Rv0317c"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     Streptomyces coelicolor cytoplasmic phosphodiesterases
                     UgpQ2 and similar proteins; Region:
                     GDPD_cytoplasmic_ScUgpQ2_like; cd08561"
                     /db_xref="CDD:176504"
     misc_feature    complement(order(385296..385298,385542..385544,
                     385620..385622,385773..385775,385812..385814,
                     385818..385820,385902..385904))
                     /gene="glpQ2"
                     /locus_tag="Rv0317c"
                     /note="putative active site [active]"
                     /db_xref="CDD:176504"
     misc_feature    complement(order(385773..385775,385902..385904))
                     /gene="glpQ2"
                     /locus_tag="Rv0317c"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176504"
     misc_feature    complement(order(385620..385622,385812..385814,
                     385818..385820))
                     /gene="glpQ2"
                     /locus_tag="Rv0317c"
                     /note="putative metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:176504"
     gene            complement(386204..386274)
                     /gene="glyU"
                     /locus_tag="Rvnt04"
                     /db_xref="GeneID:2700441"
     tRNA            complement(386204..386274)
                     /gene="glyU"
                     /locus_tag="Rvnt04"
                     /product="tRNA-Gly"
                     /note="glyU, tRNA-Gly, anticodon ccc, length = 71"
                     /anticodon=(pos:complement(386240..386242),aa:Gly,seq:ccc)
                     /codon_recognized="GGG"
                     /db_xref="GeneID:2700441"
     gene            complement(386305..387099)
                     /locus_tag="Rv0318c"
                     /db_xref="GeneID:886576"
     CDS             complement(386305..387099)
                     /locus_tag="Rv0318c"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane protein"
                     /protein_id="YP_177716.1"
                     /db_xref="GeneID:886576"
                     /translation="MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILG
                     GVVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLV
                     ALRRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALT
                     VEVLFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVL
                     AFAAGALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME"
     misc_feature    complement(386311..387084)
                     /locus_tag="Rv0318c"
                     /note="Zinc transporter ZupT [Inorganic ion transport and
                     metabolism]; Region: ZupT; COG0428"
                     /db_xref="CDD:223505"
     gene            387148..387816
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /db_xref="GeneID:886555"
     CDS             387148..387816
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to peptidase family C15 (thiol protease)."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrrolidone-carboxylate peptidase"
                     /protein_id="NP_214833.1"
                     /db_xref="GeneID:886555"
                     /translation="MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPN
                     TFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVL
                     VGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQK
                     GLPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPS
                     RLQI"
     misc_feature    387148..387813
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /note="pyrrolidone-carboxylate peptidase; Provisional;
                     Region: PRK13195"
                     /db_xref="CDD:171894"
     misc_feature    order(387172..387174,387181..387183,387277..387279,
                     387577..387585)
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /note="putative substrate binding pocket [chemical
                     binding]; other site"
                     /db_xref="CDD:238279"
     misc_feature    order(387367..387375,387532..387534,387541..387555,
                     387670..387675,387679..387681,387706..387711,
                     387715..387717)
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /note="AC domain interface; other site"
                     /db_xref="CDD:238279"
     misc_feature    order(387385..387387,387583..387585,387655..387657)
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238279"
     misc_feature    order(387388..387393,387403..387405,387409..387411,
                     387415..387417,387454..387459,387484..387495,
                     387511..387513,387562..387567,387574..387576)
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /note="AB domain interface; other site"
                     /db_xref="CDD:238279"
     misc_feature    387715..387717
                     /gene="pcp"
                     /locus_tag="Rv0319"
                     /note="interchain disulfide; other site"
                     /db_xref="CDD:238279"
     gene            387888..388550
                     /locus_tag="Rv0320"
                     /db_xref="GeneID:886553"
     CDS             387888..388550
                     /locus_tag="Rv0320"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214834.1"
                     /db_xref="GeneID:886553"
                     /translation="MGRHELARDRRKSSAVLAAVLAPAAVFFATGGDVSTLAARADAN
                     PVLGDDAPCCVQIVPVAPLAFSSQISGGEIGTGLAASQFASASRWRIVSRYLPVGVAP
                     EQGLQVKTVLTARSISAAFPEIREIGGVRPDALRWHPNGLALDVMVPNPGTAEGIALG
                     NEIVAFVLKNATRFGMQDVIWRGAYYTPNGARTTGAGHYDHIHITTVGGGYPTGEELY
                     IR"
     gene            388582..389154
                     /gene="dcd"
                     /locus_tag="Rv0321"
                     /gene_synonym="dus; paxA"
                     /db_xref="GeneID:886552"
     CDS             388582..389154
                     /gene="dcd"
                     /locus_tag="Rv0321"
                     /gene_synonym="dus; paxA"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="deoxycytidine triphosphate deaminase"
                     /protein_id="NP_214835.1"
                     /db_xref="GeneID:886552"
                     /translation="MLLSDRDLRAEISSGRLGIDPFDDTLVQPSSIDVRLDCLFRVFN
                     NTRYTHIDPAKQQDELTSLVQPVDGEPFVLHPGEFVLGSTLELFTLPDNLAGRLEGKS
                     SLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCMLRLTSPSEH
                     PYGSSRAGSKYQGQRGPTPSRSYQNFIRST"
     misc_feature    388582..389127
                     /gene="dcd"
                     /locus_tag="Rv0321"
                     /gene_synonym="dus; paxA"
                     /note="deoxycytidine triphosphate deaminase; Reviewed;
                     Region: dcd; PRK00416"
                     /db_xref="CDD:234753"
     misc_feature    order(388798..388800,388813..388818,388822..388824,
                     388870..388872,388876..388893,388906..388914,
                     388930..388932,388939..388941,388960..388962,
                     388966..388968,388972..388974,388978..388980,
                     388990..389004,389011..389013,389023..389025)
                     /gene="dcd"
                     /locus_tag="Rv0321"
                     /gene_synonym="dus; paxA"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143638"
     misc_feature    order(388882..388890,388930..388938,388945..388947,
                     388957..388962)
                     /gene="dcd"
                     /locus_tag="Rv0321"
                     /gene_synonym="dus; paxA"
                     /note="active site"
                     /db_xref="CDD:143638"
     gene            389260..390591
                     /gene="udgA"
                     /locus_tag="Rv0322"
                     /gene_synonym="rkpK"
                     /db_xref="GeneID:886550"
     CDS             389260..390591
                     /gene="udgA"
                     /locus_tag="Rv0322"
                     /gene_synonym="rkpK"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /inference="protein motif:PROSITE:PS00017"
                     /note="Belongs to the UDP-glucose/GDP-mannose
                     dehydrogenases family."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase UdgA"
                     /protein_id="NP_214836.1"
                     /db_xref="GeneID:886550"
                     /translation="MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDI
                     PFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHA
                     VIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAV
                     HDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLA
                     TKISFINAISEVCEAAGADVSQLADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMA
                     RAGELGADQALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDD
                     VRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLT
                     EWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH"
     misc_feature    389260..390531
                     /gene="udgA"
                     /locus_tag="Rv0322"
                     /gene_synonym="rkpK"
                     /note="UDP-glucose 6-dehydrogenase [Cell
                     wall/membrane/envelope biogenesis]; Region: Ugd; COG1004"
                     /db_xref="CDD:223936"
     gene            complement(390580..391251)
                     /locus_tag="Rv0323c"
                     /db_xref="GeneID:886557"
     CDS             complement(390580..391251)
                     /locus_tag="Rv0323c"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214837.1"
                     /db_xref="GeneID:886557"
                     /translation="MNSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGL
                     CFTHGEASTLGRTDRNLGEVRREELAAAAQVLGVDHVQLLAYPDNGLAQIPLNELTQR
                     VVDALAGADLLLVFDDNGVTGHPDHRRATEAALAAASTPSIPVLAWALPQPIADRLNA
                     EFSASFGGRGHGHLDIMIEVDRSRQLAAIGCHFTQSADNPVLWRRLELLGDREYLRWL
                     RRSVP"
     misc_feature    complement(390592..391251)
                     /locus_tag="Rv0323c"
                     /note="N-acetylglucosaminyl deacetylase, LmbE family
                     [Carbohydrate transport and metabolism]; Region: LmbE;
                     COG2120"
                     /db_xref="CDD:225031"
     gene            391352..392032
                     /locus_tag="Rv0324"
                     /db_xref="GeneID:886548"
     CDS             391352..392032
                     /locus_tag="Rv0324"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214838.1"
                     /db_xref="GeneID:886548"
                     /translation="MAGQSDRKAALLDQVARVGKALANGRRLQILDLLAQGERAVEAI
                     ATATGMNLTTASANLQALKSGGLVEARREGTRQYYRIAGEDVARLFALVQVVADEHLA
                     DVAVAAADVLGSPEDAITRAELLRRREAGEVTLVDVRPHEEYQAGHIPGAINIPIAEL
                     ADRLAELTGDRDIVAYCRGAYCVMAPDAVRIARDAGREVKRLDDGMLEWRLAGLPVDE
                     GAPVGHGD"
     misc_feature    order(391406..391411,391415..391417,391424..391426,
                     391433..391438,391445..391450,391457..391459,
                     391547..391549,391613..391618,391622..391630,
                     391634..391642)
                     /locus_tag="Rv0324"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238042"
     misc_feature    order(391409..391414,391424..391432,391469..391477,
                     391502..391513,391517..391522,391529..391534,
                     391538..391543,391559..391567,391580..391588)
                     /locus_tag="Rv0324"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:238042"
     misc_feature    391436..391633
                     /locus_tag="Rv0324"
                     /note="helix_turn_helix, Arsenical Resistance Operon
                     Repressor; Region: HTH_ARSR; smart00418"
                     /db_xref="CDD:197713"
     misc_feature    order(391469..391471,391478..391480,391613..391615)
                     /locus_tag="Rv0324"
                     /note="putative Zn2+ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238042"
     misc_feature    391718..391981
                     /locus_tag="Rv0324"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cd00158"
                     /db_xref="CDD:238089"
     misc_feature    391880..391882
                     /locus_tag="Rv0324"
                     /note="active site residue [active]"
                     /db_xref="CDD:238089"
     gene            392039..392263
                     /locus_tag="Rv0325"
                     /db_xref="GeneID:886546"
     CDS             392039..392263
                     /locus_tag="Rv0325"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214839.1"
                     /db_xref="GeneID:886546"
                     /translation="MGPKGSLRLVKRQPELLVAQHEHWQDTYRAHPVLYGTRPSEPGV
                     YAAEVFNADGVQRVLELAAGHGRDTLYFAG"
     gene            392273..392728
                     /locus_tag="Rv0326"
                     /db_xref="GeneID:886544"
     CDS             392273..392728
                     /locus_tag="Rv0326"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214840.1"
                     /db_xref="GeneID:886544"
                     /translation="MVATDFSDVAVAQLRRSAQARGVSARVQPIVHDLRQPLPVKTGS
                     IDGAFAHMALCMALSTSEIHAVVAEVGRVLRPGGKFIYTVRHTGDAHYGAGQAHGDDI
                     FECAGFAVHFFRRELVARLATGWVLEEVHDFEEGELPRRLWRVTVTKPA"
     misc_feature    <392276..392506
                     /locus_tag="Rv0326"
                     /note="Methyltransferase domain; Region: Methyltransf_25;
                     pfam13649"
                     /db_xref="CDD:316196"
     gene            complement(392696..394045)
                     /gene="cyp135A1"
                     /locus_tag="Rv0327c"
                     /db_xref="GeneID:886538"
     CDS             complement(392696..394045)
                     /gene="cyp135A1"
                     /locus_tag="Rv0327c"
                     /inference="protein motif:PROSITE:PS00086"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome P450 Cyp135A1"
                     /protein_id="NP_214841.1"
                     /db_xref="GeneID:886538"
                     /translation="MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFS
                     LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHAR
                     MRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFG
                     VTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIA
                     SRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLW
                     ELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPA
                     GTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTE
                     GAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP"
     misc_feature    complement(392732..394018)
                     /gene="cyp135A1"
                     /locus_tag="Rv0327c"
                     /note="Cytochrome P450 [Secondary metabolites
                     biosynthesis, transport and catabolism, Defense
                     mechanisms]; Region: CypX; COG2124"
                     /db_xref="CDD:225035"
     gene            394111..394713
                     /locus_tag="Rv0328"
                     /db_xref="GeneID:886542"
     CDS             394111..394713
                     /locus_tag="Rv0328"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214842.1"
                     /db_xref="GeneID:886542"
                     /translation="MQQQRTNRDKLLDGALACLRERGYGNTSSRDIARAAGVNIASIN
                     YHFGSKDALLDDALGRCFSTWNQRVQEAFDHSRAAGPAGQILAVLEATVDSFEQIRPA
                     VYACVESYAPALRSEALRERLAAGYADVRQHSVDLAGAALAGTDIAPPENLSTIVSVL
                     MAVIDGLMIQWIADPSATPRSTEVIRALASIGAVVTSQLR"
     misc_feature    394117..394677
                     /locus_tag="Rv0328"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            complement(394694..395320)
                     /locus_tag="Rv0329c"
                     /db_xref="GeneID:886536"
     CDS             complement(394694..395320)
                     /locus_tag="Rv0329c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214843.1"
                     /db_xref="GeneID:886536"
                     /translation="MRLTHPARRYLSSQAARPTGAFGRLLGRIWRAETADVNRIAVEL
                     LAPGPGERVCEIGFGPGRTLGLLAAAGAQVSGVEVSTTMIAIAAHHNAKAIAAGLISL
                     YHGDGVTLPVADHSLDKVLGVHNFYFWPDPRASLCDIARALRPGGRLVLTSISDDQPL
                     AARFDPAIYRVPPTLDTAAWLGAAGFIDVGIKRSADHPATVWFTATAT"
     misc_feature    complement(394868..395158)
                     /locus_tag="Rv0329c"
                     /note="Methyltransferase domain; Region: Methyltransf_11;
                     pfam08241"
                     /db_xref="CDD:311935"
     misc_feature    complement(order(394952..394954,395000..395008,
                     395084..395089,395135..395155))
                     /locus_tag="Rv0329c"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:100107"
     gene            complement(395347..396087)
                     /locus_tag="Rv0330c"
                     /db_xref="GeneID:886540"
     CDS             complement(395347..396087)
                     /locus_tag="Rv0330c"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214844.1"
                     /db_xref="GeneID:886540"
                     /translation="MARSIPADRFSAIVAASARVFIAHGYQRTQVQDVADALALAKGT
                     LYGYAQGKAALFAAAVRYGDAQEALPLASELPVAAPVAGEIAAVVSARLAGEVTDMRL
                     THALRATLPPGATTGDARAELAGIVTDLYSRLARHRIALKLVDRCAPELPDLAEVWFG
                     TGRNAQVDAVQAYLVHRERAGLLILPGPAPMVARTIVELCALWAVHLHFDPSPEPWSI
                     VQPGVIDDDAIAATLAEFVVRATTASSD"
     misc_feature    complement(395911..396051)
                     /locus_tag="Rv0330c"
                     /note="Bacterial regulatory proteins, tetR family; Region:
                     TetR_N; pfam00440"
                     /db_xref="CDD:306858"
     gene            396201..397367
                     /locus_tag="Rv0331"
                     /db_xref="GeneID:886534"
     CDS             396201..397367
                     /locus_tag="Rv0331"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="dehydrogenase/reductase"
                     /protein_id="NP_214845.1"
                     /db_xref="GeneID:886534"
                     /translation="MSKTVLILGAGVGGLTTADTLRQLLPPEDRIILVDRSFDGTLGL
                     SLLWVLRGWRRPDDVRVRPTAASLPGVEMVTATVAHIDIAAQVVHTDNSVIGYDALVI
                     ALGAALNTDAVPGLSDALDADVAGQFYTLDGAAELRAKVEALEHGRIAVAIAGVPFKC
                     PAAPFEAAFLIAAQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSMLKDHGVGF
                     HPRKALARVDEAARTMHFGDGTSEPFDLLAVVPPHVPSAAARSAGLSESGWIPVDPRT
                     LSTSADNVWAIGDATVLTLPNGKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTG
                     TGACYVETGDHQAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT"
     misc_feature    396213..397247
                     /locus_tag="Rv0331"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; Region: FadH2; COG0446"
                     /db_xref="CDD:223523"
     gene            397442..398227
                     /locus_tag="Rv0332"
                     /db_xref="GeneID:886532"
     CDS             397442..398227
                     /locus_tag="Rv0332"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214846.1"
                     /db_xref="GeneID:886532"
                     /translation="MRKPASSLAKVDYSSAYLEQTHAFGELIRNVDQSTPVPTCPGWS
                     LGQLFRHVGRGDRWAAQIVRDRLDHFLDPRSVEGGKPPPDPDDAISWLYGGARLLVDA
                     VEQTGVETPVWTFLGPRPAGWWVRRRLHEVAVHRADVAITVGGEFTLEPNVAADGISE
                     FLERIAVQAGSGGTPLPLEDDDTLHLHATDPGLLEAGEWTVRRDERGVTWSHRHGKGA
                     VALRGGATELLLAMVRRLSVADTGIELLGDAGVWQKWLDRTPL"
     misc_feature    397487..398146
                     /locus_tag="Rv0332"
                     /note="uncharacterized Actinobacterial protein TIGR03083;
                     Region: TIGR03083"
                     /db_xref="CDD:274422"
     gene            398254..398628
                     /locus_tag="Rv0333"
                     /db_xref="GeneID:886528"
     CDS             398254..398628
                     /locus_tag="Rv0333"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214847.1"
                     /db_xref="GeneID:886528"
                     /translation="MTTSEIATVLAWHDALNAADIETLVALSTDDIDIGDAHGAVQGH
                     DALRGWASSLTTTAELGRMYVHHGVVVVEQKITSGEDPGIARTGAAAFRVVQDHVASV
                     FRHEDLASALAATELTEDDLVD"
     misc_feature    398284..398574
                     /locus_tag="Rv0333"
                     /note="SnoaL-like domain; Region: SnoaL_2; pfam12680"
                     /db_xref="CDD:315371"
     gene            398658..399524
                     /gene="rmlA"
                     /locus_tag="Rv0334"
                     /gene_synonym="rfbA"
                     /db_xref="GeneID:886568"
     CDS             398658..399524
                     /gene="rmlA"
                     /locus_tag="Rv0334"
                     /gene_synonym="rfbA"
                     /experiment="DESCRIPTION:Gene expression[PMID:9084178]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="alpha-D-glucose-1-phosphate thymidylyltransferase
                     RmlA"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="NP_214848.1"
                     /db_xref="GeneID:886568"
                     /translation="MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMA
                     GIRDIQLITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSV
                     ALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKP
                     VTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGT
                     AWLDTGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSG
                     YGNYLLELLERN"
     misc_feature    398661..399515
                     /gene="rmlA"
                     /locus_tag="Rv0334"
                     /gene_synonym="rfbA"
                     /note="glucose-1-phosphate thymidylyltransferase, short
                     form; Region: rmlA; TIGR01207"
                     /db_xref="CDD:130274"
     gene            complement(399535..400050)
                     /gene="PE6"
                     /locus_tag="Rv0335c"
                     /db_xref="GeneID:886527"
     CDS             complement(399535..400050)
                     /gene="PE6"
                     /locus_tag="Rv0335c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="PE family protein PE6"
                     /protein_id="YP_177717.1"
                     /db_xref="GeneID:886527"
                     /translation="MRSMGFLHRACRAPSSLPAPLMARPGRSVLARPAATPPGPLCAT
                     TRPRPPQGNQPPASRISNFPPKRHKTRVLAAAEDEVSAAVAALISAHGRRHHSLNNQA
                     AAFHGQFAQNLNVGAGSCASAETTADAPTQALLGPADRQRRQRRAVRQWLVRWAAHPG
                     RATRGFHNHRQ"
     misc_feature    complement(399685..>399843)
                     /gene="PE6"
                     /locus_tag="Rv0335c"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:307197"
     gene            400192..401703
                     /locus_tag="Rv0336"
                     /db_xref="GeneID:886524"
     CDS             400192..401703
                     /locus_tag="Rv0336"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214850.1"
                     /db_xref="GeneID:886524"
                     /translation="MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAA
                     AQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRE
                     RLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLA
                     GQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSAL
                     AGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEA
                     ATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADF
                     VRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQ
                     QLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPK
                     RRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDPNDDPPPF"
     misc_feature    400291..401208
                     /locus_tag="Rv0336"
                     /note="Domain of unknown function (DUF222); Region:
                     DUF222; pfam02720"
                     /db_xref="CDD:308380"
     misc_feature    401203..401346
                     /locus_tag="Rv0336"
                     /note="HNH nucleases; HNH endonuclease signature which is
                     found in viral, prokaryotic, and eukaryotic proteins. The
                     alignment includes members of the large group of homing
                     endonucleases, yeast intron 1 protein, MutS, as well as
                     bacterial colicins, pyocins, and...; Region: HNHc;
                     cd00085"
                     /db_xref="CDD:238038"
     misc_feature    order(401254..401256,401260..401268,401272..401274,
                     401305..401310,401320..401325,401332..401334,
                     401344..401346)
                     /locus_tag="Rv0336"
                     /note="active site"
                     /db_xref="CDD:238038"
     gene            complement(401873..403162)
                     /gene="aspC"
                     /locus_tag="Rv0337c"
                     /db_xref="GeneID:886522"
     CDS             complement(401873..403162)
                     /gene="aspC"
                     /locus_tag="Rv0337c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /note="Belongs to class-I of pyridoxal-phosphate-dependent
                     aminotransferases. Cofactor: pyridoxal phosphate."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate aminotransferase"
                     /protein_id="NP_214851.1"
                     /db_xref="GeneID:886522"
                     /translation="MDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGP
                     VHQHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSAR
                     RAVVTRYELVPGFPRFDVDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTAS
                     TSLAGGTPVHYLCDETQGWQPDIADLESKITERTKALVVINPNNPTGAVYSCEILTQM
                     VDLARKHQLLLLADEIYDKILYDDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGW
                     LAITGPKEHASSFIEGIGLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQ
                     RDIAWTKLNEIPGVSCVKPAGALYAFPRLDPEVYDIDDDEQLVLDLLLSEKILVTQGT
                     GFNWPAPDHLRLVTLPWSRDLAAAIERLGNFLVSYRQ"
     misc_feature    complement(401876..403090)
                     /gene="aspC"
                     /locus_tag="Rv0337c"
                     /note="aminotransferase AlaT; Validated; Region: PRK09265"
                     /db_xref="CDD:181738"
     gene            complement(403193..405841)
                     /locus_tag="Rv0338c"
                     /db_xref="GeneID:886520"
     CDS             complement(403193..405841)
                     /locus_tag="Rv0338c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00070"
                     /inference="protein motif:PROSITE:PS00198"
                     /codon_start=1
                     /transl_table=11
                     /product="iron-sulfur-binding reductase"
                     /protein_id="NP_214852.1"
                     /db_xref="GeneID:886520"
                     /translation="MTTQTLIRLILGMSMTAVVGVFALRRVWWLYKLVMSGQPASGRT
                     DNLGTRIWTQISEVLGQRRLLKWSIPGLAHFFTMWGFFILLTVYIEAYGLLFEERFHI
                     PVIGRWDALGFLQDFFATAVFLGITTFAIIRILRNPREIGRSSRFYGSHNGGAWLVLL
                     MIFNVIWTYVLVRGSAVNNGTLPYGNGAFLSQLFGAILRPLGQPANEIIETTALLLHI
                     GVMLAFLILVLHSKHLHIFLAPINVTFKRLPDGLGPLLPLEADGKPIDFENPSEDAVF
                     GRGKIEDFTWKGMLDFATCTECGRCQSQCPAWNTGKPLSPKLVIMDLRDHWMAKAPYI
                     LGQKDASAGGEAGHQEHHHVPESGFGRVPGHGPEQATRPLVGTEEQGGVIDPDVLWSC
                     VTCGACVEQCPVDIEHVDHIVDMRRYQVMMESEFPSELSVLFKNLETKGNPWGQNASD
                     RTNWIDEVDFDVPVYGQDVDSFDGYEYLFWVGCAGAYDDKAKKTTKAVAELLAVARVK
                     YLVLGAGETCNGDSARRSGNEFLFQQLAQQAVETLDGLFEGVETVDRKIVVTCPHCFN
                     TIGKEYRQLGANYTVLHHTQLLNRLVRDKRLVPVTPVSQDITYHDPCYLGRHNKAYEA
                     PRELIGAAGASLTEMPRHADRSFCCGAGGARMWMEEHIGKRINHERVDEALATDATAI
                     ATACPFCRVMVTDGVNDRQEEAGRSGVEVLDVAQVLLGSLDHDKAQLPAKGTAAKQAQ
                     ERAPKAAPKAAAPVTPVEAPAEAPQAPAPAAPAAPVKGLGMAAGAKRPGAKKAAPTPA
                     APAAPAAPVKGLGIAAGAKRPGAKKTPPPAPGLAEPAAQPQPEAKPQPEPAAPPKPQT
                     DGDPAAPAAPVKGLGIARGARPPGKR"
     misc_feature    complement(403679..404989)
                     /locus_tag="Rv0338c"
                     /note="Fe-S oxidoreductase [Energy production and
                     conversion]; Region: GlpC; COG0247"
                     /db_xref="CDD:223325"
     misc_feature    complement(403226..>403399)
                     /locus_tag="Rv0338c"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; cl25865"
                     /db_xref="CDD:330686"
     gene            complement(405950..408448)
                     /locus_tag="Rv0339c"
                     /db_xref="GeneID:886516"
     CDS             complement(405950..408448)
                     /locus_tag="Rv0339c"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214853.1"
                     /db_xref="GeneID:886516"
                     /translation="MQHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVK
                     VLITGGIGTGKTTVLAAARDTLRRSGLTVLACPPPDGEPPETALVIDDAQLLTDTELL
                     RLTERVADSRLTVVAAAEAREHHRALRALTMALERDRPRISLGPLPVAEHLRDCTAGL
                     PFLIHAVSARAQAPAQAAKVALIERLRRLDEPTLDTLLMMSLTHELGVSDVAAALGIS
                     VTDARGLVDRAHASGLIESSHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDISP
                     VSAELALRLAEHGLRDERLADILTRYAADTRDASVRCARLYRAAVHAGAKGLTVRLAD
                     ALARTGDCTAAATLADDLLSSPDATERAAAVRVAASVAVHDGNTGHAAELFGWLGPHP
                     DTMVSSAATIVFAANGDLATARATLRLKDAGPPTMAARCARNLAEGLLLTMDQPYPVA
                     MAKLGQAIATEQSLSQVIPDSPAALVTLAAIHAGDPVRARSVIGRAVRAGADPLFQRR
                     HLLLSGWIKMQEGQLPSASADVAAASAGTHLHRRDALWAAALQTAISRRTGDIGALQQ
                     HWYAAMEALAEYSLDLFALLPLGELWVAAARMRQVDQLQHTLDQALTLLDSLGNPALW
                     SNSLHWAGVHAGILANSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDA
                     DEVTAAARSLSHVGLTSDATRLAGQAALQTSDARVSGAMLQLARDLKLGNDFGEPPSG
                     AGDTEPASGTPPAPRQPPAGSPLSDREREVAELLLLGMPYRDIGARLFISAKTVEHHV
                     ARIRQRLGAGSRSEMLSMLRAMLAPESLTADERR"
     misc_feature    complement(405998..406165)
                     /locus_tag="Rv0339c"
                     /note="helix_turn_helix, Lux Regulon; Region: HTH_LUXR;
                     smart00421"
                     /db_xref="CDD:197715"
     misc_feature    complement(order(406019..406021,406052..406066,
                     406070..406075,406079..406084,406106..406114,
                     406151..406159))
                     /locus_tag="Rv0339c"
                     /note="DNA binding residues [nucleotide binding]"
                     /db_xref="CDD:99777"
     misc_feature    complement(order(405995..405997,406004..406006,
                     406013..406021,406112..406114,406118..406120,
                     406124..406126))
                     /locus_tag="Rv0339c"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:99777"
     gene            408634..409173
                     /locus_tag="Rv0340"
                     /db_xref="GeneID:886514"
     CDS             408634..409173
                     /locus_tag="Rv0340"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214854.1"
                     /db_xref="GeneID:886514"
                     /translation="MANSLLDFVISLVRDPEAAARYAANPERSIAEAHLTDVTRADVN
                     SLIPVVSDSLSMSEPIGAAGGAHAGDRGNVWASGAATAALDAFAPHADAGVVQQHGAV
                     GSVLNQPTPPGPGVTPTDPRPFRAGPHETSALLTSAEIPDTTSEDGGLPTDHPAVWNH
                     PVVDPHTVEPDHHGYDIHG"
     gene            409362..410801
                     /gene="iniB"
                     /locus_tag="Rv0341"
                     /db_xref="GeneID:886518"
     CDS             409362..410801
                     /gene="iniB"
                     /locus_tag="Rv0341"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="isoniazid inducible protein IniB"
                     /protein_id="NP_214855.1"
                     /db_xref="GeneID:886518"
                     /translation="MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISS
                     VAANVVPGLNLGAGDPMSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAG
                     LASGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGT
                     GLGAQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGA
                     GVGAGVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGA
                     ALNGAAMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAA
                     AGVVGGVGGATAAGVGGAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGG
                     TGGYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVTQPQHTPVEPPVHDKPPSHSVF
                     DVGHEPPVTHTPPAPIELPSYGLFGLPGF"
     misc_feature    <410562..>410777
                     /gene="iniB"
                     /locus_tag="Rv0341"
                     /note="Atrophin-1 family; Region: Atrophin-1; cl26464"
                     /db_xref="CDD:331285"
     gene            410838..412760
                     /gene="iniA"
                     /locus_tag="Rv0342"
                     /db_xref="GeneID:886510"
     CDS             410838..412760
                     /gene="iniA"
                     /locus_tag="Rv0342"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis[PMID:15752203]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="Note that the iniA gene is also induced by the
                     antibiotic ethambutol, an agent that inhibits cell wall
                     biosynthesis by a mechanism that is distinct from
                     isoniazid."
                     /codon_start=1
                     /transl_table=11
                     /product="isoniazid inductible protein IniA"
                     /protein_id="NP_214856.1"
                     /db_xref="GeneID:886510"
                     /translation="MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTI
                     AIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDE
                     ATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEV
                     GAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFV
                     RQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLN
                     DKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDP
                     NLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAE
                     RQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVL
                     SAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGL
                     FNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMI
                     QRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNL
                     AGLEPTLTPRASLGRA"
     misc_feature    410838..412670
                     /gene="iniA"
                     /locus_tag="Rv0342"
                     /note="Replication fork clamp-binding protein CrfC
                     (dynamin-like GTPase family) [Replication, recombination
                     and repair]; Region: CrfC; COG0699"
                     /db_xref="CDD:223771"
     gene            412757..414238
                     /gene="iniC"
                     /locus_tag="Rv0343"
                     /db_xref="GeneID:886508"
     CDS             412757..414238
                     /gene="iniC"
                     /locus_tag="Rv0343"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="iIsoniazid inductible protein IniC"
                     /protein_id="NP_214857.1"
                     /db_xref="GeneID:886508"
                     /translation="MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEP
                     LRIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRA
                     NVPITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLR
                     LLVPADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAG
                     RIDAMLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAER
                     TELNRALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAA
                     ELLERSGLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLL
                     ADTHAFEELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRA
                     ALAAAQHWRRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR"
     misc_feature    412766..414235
                     /gene="iniC"
                     /locus_tag="Rv0343"
                     /note="Replication fork clamp-binding protein CrfC
                     (dynamin-like GTPase family) [Replication, recombination
                     and repair]; Region: CrfC; COG0699"
                     /db_xref="CDD:223771"
     gene            complement(414381..414941)
                     /gene="lpqJ"
                     /locus_tag="Rv0344c"
                     /db_xref="GeneID:886512"
     CDS             complement(414381..414941)
                     /gene="lpqJ"
                     /locus_tag="Rv0344c"
                     /inference="protein motif:PROSITE:PS00013"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein LpqJ"
                     /protein_id="NP_214858.1"
                     /db_xref="GeneID:886512"
                     /translation="MRLSLIARGMAALLAATALVAGCNTTIDGRPVASPGSGPTEPTF
                     PTPRPTTAPPGTTAPTLPTTPVSPTAPAGAIPLPPDSNGYVFIETKSGMTRCQINRDS
                     VGCEAPFTNSPLRDGEHANGIHITAGGSVQWVLGNLGAIPTVSIDYRTYEAQGWTIDA
                     TTDGTRFTNNRTGHGMFVSIEKVDTF"
     gene            415050..415460
                     /locus_tag="Rv0345"
                     /db_xref="GeneID:886505"
     CDS             415050..415460
                     /locus_tag="Rv0345"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214859.1"
                     /db_xref="GeneID:886505"
                     /translation="MLPSTVVGVLLAAGAGRWYGKPKVLVDGWLDTAVGALRDGGCND
                     VILVLGAVEVSAPAGVTAITAPDWQQGLSASVRAGLAQADREHADYAVLHVIDTPDVN
                     AKVVARVLGRALVSRSGLAGRGRIPAHSARRRGC"
     misc_feature    415050..>415388
                     /locus_tag="Rv0345"
                     /note="CTP:molybdopterin cytidylyltransferase MocA
                     [Coenzyme transport and metabolism]; Region: MocA;
                     COG2068"
                     /db_xref="CDD:224979"
     misc_feature    order(415080..415082,415086..415088,415188..415190,
                     415332..415334,415338..415340)
                     /locus_tag="Rv0345"
                     /note="active site"
                     /db_xref="CDD:132997"
     gene            complement(415502..416965)
                     /gene="ansP2"
                     /locus_tag="Rv0346c"
                     /gene_synonym="aroP2"
                     /db_xref="GeneID:886530"
     CDS             complement(415502..416965)
                     /gene="ansP2"
                     /locus_tag="Rv0346c"
                     /gene_synonym="aroP2"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-asparagine permease"
                     /protein_id="YP_177718.1"
                     /db_xref="GeneID:886530"
                     /translation="MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGA
                     GGRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVA
                     GWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGE
                     LEFWASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVT
                     SGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAY
                     KEHVSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRF
                     TAPMSKTGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQ
                     LRLHRMANAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGV
                     PALIGGWYLVRNRVTAVAHHAIDHTKSVAVVHSADPI"
     misc_feature    complement(415547..416941)
                     /gene="ansP2"
                     /locus_tag="Rv0346c"
                     /gene_synonym="aroP2"
                     /note="L-asparagine transporter and related permeases
                     [Amino acid transport and metabolism]; Region: AnsP;
                     COG1113"
                     /db_xref="CDD:224038"
     gene            417304..418290
                     /locus_tag="Rv0347"
                     /db_xref="GeneID:886501"
     CDS             417304..418290
                     /locus_tag="Rv0347"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214861.1"
                     /db_xref="GeneID:886501"
                     /translation="MPGARELTLRVERGALFRRRWAASAASSARAAIRRDPRRCALGT
                     RPRWVSFLVIVLVIMNVVTAHPKYPNDPLALVLIELRHPRTEPPVPSAISILKEELAR
                     WTPILEQEEVRQVNLETGEHTAHSQKKLVARDRRTAITFRPDAMTLEVTDYPGWEEFR
                     SIVHAMVTARQDVAPVDGCIRIGLRYINEIRASLAEPSGWAYWVAESLLGPGTQLADL
                     KLTTTAQRHVIQCEGPEPGDSLTLRYAGARGAVIQSTPFLQRLKEPPAEGDFFLIDID
                     SAWSDPCKGIPALDAHLVDEVAERLHTPIGPLFESLITSELRTKVLQQPGQE"
     misc_feature    417502..418263
                     /locus_tag="Rv0347"
                     /note="TIGR04255 family protein; Region: sporadTIGR04255"
                     /db_xref="CDD:275082"
     gene            418293..418946
                     /locus_tag="Rv0348"
                     /db_xref="GeneID:886500"
     CDS             418293..418946
                     /locus_tag="Rv0348"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214862.1"
                     /db_xref="GeneID:886500"
                     /translation="MTISFSSSNLRDDATSGNGDYRLDKLPETTPSTSVFDRADVTYR
                     QFTELHGQARDTRREAHVVELESKTGERARCAPMHALEQLADYGFAWRDIARVVGVSV
                     PAITKWRKGAGVTGENRLKIARLLALIDMLSDRFIGEPASWLEMPIQAGVGITRMDLL
                     ERGRYDLVLALASTHTGDGTVEYVLNETDKDWRETVVDNAFESYTAEDGVISIRPKR"
     gene            418949..419608
                     /locus_tag="Rv0349"
                     /db_xref="GeneID:886506"
     CDS             418949..419608
                     /locus_tag="Rv0349"
                     /note="This region is a possible MT-complex-specific
                     genomic island (See Becq et al., 2007 PMID:17545187)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214863.1"
                     /db_xref="GeneID:886506"
                     /translation="MPELETPDDPESIYLARLEDVGEHRPTFTGDIYRLGDGRMVMIL
                     QHPCALRHGVDLHPRLLVAPVRPDSLRSNWARAPFGTMPLPKLIDGQDHSADFINLEL
                     IDSPTLPTCERIAVLSQSGVNLVMQRWVYHSTRLAVPTHTYSDSTVGPFDEADLIEEW
                     VTDRVDDGADPQAAEHECASWLDERISGRTRRALLSDRQHASSIRREARSHRKSVKLA
                     D"
     gene            419835..421712
                     /gene="dnaK"
                     /locus_tag="Rv0350"
                     /gene_synonym="hsp70"
                     /db_xref="GeneID:885946"
     CDS             419835..421712
                     /gene="dnaK"
                     /locus_tag="Rv0350"
                     /gene_synonym="hsp70"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="heat shock protein 70 (heat shock 70 kDa protein)
                     (HSP70)"
                     /codon_start=1
                     /transl_table=11
                     /product="chaperone protein DnaK"
                     /protein_id="NP_214864.1"
                     /db_xref="GeneID:885946"
                     /translation="MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFAR
                     NGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRD
                     AEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKG
                     EKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKG
                     TSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRA
                     EFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKE
                     PNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTI
                     PTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTF
                     DIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEAD
                     VRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSA
                     MEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREA
                     K"
     misc_feature    419835..421634
                     /gene="dnaK"
                     /locus_tag="Rv0350"
                     /gene_synonym="hsp70"
                     /note="molecular chaperone DnaK; Provisional; Region:
                     dnaK; PRK00290"
                     /db_xref="CDD:234715"
     gene            421709..422416
                     /gene="grpE"
                     /locus_tag="Rv0351"
                     /db_xref="GeneID:886497"
     CDS             421709..422416
                     /gene="grpE"
                     /locus_tag="Rv0351"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS01071"
                     /note="HSP-70 cofactor"
                     /codon_start=1
                     /transl_table=11
                     /product="stress response protein GrpE"
                     /protein_id="NP_214865.1"
                     /db_xref="GeneID:886497"
                     /translation="MTDGNQKPDGNSGEQVTVTDKRRIDPETGEVRHVPPGDMPGGTA
                     AADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDL
                     ERARKHGDLESGPLKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGS
                     KPVIGTVMRQGYQLGEQVLRHALVGVVDTVVVDAAELESVDDGTAVADTAENDQADQG
                     NSADTSGEQAESEPSGS"
     misc_feature    421727..422395
                     /gene="grpE"
                     /locus_tag="Rv0351"
                     /note="heat shock protein GrpE; Provisional; Region:
                     PRK14142"
                     /db_xref="CDD:237623"
     misc_feature    421874..422026
                     /gene="grpE"
                     /locus_tag="Rv0351"
                     /note="2-helical coiled coil [structural motif]; Region:
                     2-helical coiled coil"
                     /db_xref="CDD:271355"
     misc_feature    order(421880..421882,421889..421894,421901..421906,
                     421910..421915,421922..421930,421934..421936,
                     421943..421948,421955..421960,421967..421972,
                     421976..421981,421988..421996,422000..422014,
                     422018..422023,422051..422056,422060..422068,
                     422075..422077,422093..422098)
                     /gene="grpE"
                     /locus_tag="Rv0351"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:271355"
     misc_feature    order(421928..421930,421952..421954,422018..422020,
                     422027..422029,422132..422134,422138..422143,
                     422147..422161,422210..422212,422237..422239,
                     422249..422251,422255..422257)
                     /gene="grpE"
                     /locus_tag="Rv0351"
                     /note="Hsp70 (ATPase domain) interactions [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271355"
     misc_feature    422051..422098
                     /gene="grpE"
                     /locus_tag="Rv0351"
                     /note="2-helical coiled coil [structural motif]; Region:
                     2-helical coiled coil"
                     /db_xref="CDD:271355"
     gene            422452..423639
                     /gene="dnaJ1"
                     /locus_tag="Rv0352"
                     /gene_synonym="dnaJ"
                     /db_xref="GeneID:886495"
     CDS             422452..423639
                     /gene="dnaJ1"
                     /locus_tag="Rv0352"
                     /gene_synonym="dnaJ"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00636"
                     /inference="protein motif:PROSITE:PS00637"
                     /note="Cofactor: binds two zinc ions per monomer."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperone protein DnaJ"
                     /protein_id="YP_177719.1"
                     /db_xref="GeneID:886495"
                     /translation="MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPG
                     NPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVG
                     GDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVE
                     AAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTD
                     CRGSGSIIEHPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGD
                     LYVTVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGTVGVRVPKGTADGR
                     ILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWA
                     GNR"
     misc_feature    422452..423630
                     /gene="dnaJ1"
                     /locus_tag="Rv0352"
                     /gene_synonym="dnaJ"
                     /note="chaperone protein DnaJ; Provisional; Region:
                     PRK14279"
                     /db_xref="CDD:237655"
     gene            423639..424019
                     /gene="hspR"
                     /locus_tag="Rv0353"
                     /db_xref="GeneID:885929"
     CDS             423639..424019
                     /gene="hspR"
                     /locus_tag="Rv0353"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to the MerR family of transcriptional
                     regulators."
                     /codon_start=1
                     /transl_table=11
                     /product="heat shock protein transcriptional repressor
                     HspR"
                     /protein_id="NP_214867.1"
                     /db_xref="GeneID:885929"
                     /translation="MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTS
                     GGGRRYSLHDVELLRQVQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVL
                     RANQRREVAVVPKSTALVVWKPRR"
     misc_feature    423672..423965
                     /gene="hspR"
                     /locus_tag="Rv0353"
                     /note="Helix-Turn-Helix DNA binding domain of HspR-like
                     transcription regulators; Region: HTH_HspR-like; cd01279"
                     /db_xref="CDD:133387"
     misc_feature    order(423678..423686,423726..423728,423774..423782)
                     /gene="hspR"
                     /locus_tag="Rv0353"
                     /note="DNA binding residues [nucleotide binding]"
                     /db_xref="CDD:133387"
     misc_feature    order(423816..423818,423825..423827,423840..423845,
                     423870..423872,423900..423902,423912..423914,
                     423930..423932,423942..423944,423951..423956)
                     /gene="hspR"
                     /locus_tag="Rv0353"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:133387"
     gene            complement(424269..424694)
                     /gene="PPE7"
                     /locus_tag="Rv0354c"
                     /db_xref="GeneID:886498"
     CDS             complement(424269..424694)
                     /gene="PPE7"
                     /locus_tag="Rv0354c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE7"
                     /protein_id="YP_177720.1"
                     /db_xref="GeneID:886498"
                     /translation="MSVCVIYIPFKGCVKHVSVTIPITTEHLGPYEIDASTINPDQPI
                     DTAFTQTLDFAGSGTVGAFPFGFGWQQSPGFFNSTTTPSSGFFNSGAGGASGFLNDAA
                     AAVSGLGNVFTETSGFFNAGGVGIRASKTSATCCRAGRT"
     gene            complement(424777..434679)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /db_xref="GeneID:886491"
     CDS             complement(424777..434679)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE8"
                     /protein_id="YP_177721.2"
                     /db_xref="GeneID:886491"
                     /translation="MSFAVLPPEINSARLYVGAGLAPMLDAAAAWDGLADELGSAAAS
                     FSAVTAGLAGSSWLGAASTAMTGAAAPYLGWLSAAAAQAQQAATQTRLAAAAFEAALA
                     ATVHPAIISANRALFVSLVVSNLLGQNAPAIAATEAAYEQMWAQDVAAMFGYHAGASA
                     AVSALTPFGQALPTVAGGGALVSAAAAQVTTRVFRNLGLANVGEGNVGNGNVGNFNLG
                     SANIGNGNIGSGNIGSSNIGFGNVGPGLTAALNNIGFGNTGSNNIGFGNTGSNNIGFG
                     NTGDGNRGIGLTGSGLLGFGGLNSGTGNIGLFNSGTGNVGIGNSGTGNWGIGNSGNSY
                     NTGFGNSGDANTGFFNSGIANTGVGNAGNYNTGSYNPGNSNTGGFNMGQYNTGYLNSG
                     NYNTGLANSGNVNTGAFITGNFNNGFLWRGDHQGLIFGSPGFFNSTSAPSSGFFNSGA
                     GSASGFLNSGANNSGFFNSSSGAIGNSGLANAGVLVSGVINSGNTVSGLFNMSLVAIT
                     TPALISGFFNTGSNMSGFFGGPPVFNLGLANRGVVNILGNANIGNYNILGSGNVGDFN
                     ILGSGNLGSQNILGSGNVGSFNIGSGNIGVFNVGSGSLGNYNIGSGNLGIYNIGFGNV
                     GDYNVGFGNAGDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNIASGWNSGTG
                     NSGLFNSGTNNVGIFNAGTGNVGIANSGTGNWGIGNPGTDNTGILNAGSYNTGILNAG
                     DFNTGFYNTGSYNTGGFNVGNTNTGNFNVGDTNTGSYNPGDTNTGFFNPGNVNTGAFD
                     TGDFNNGFLVAGDNQGQIAIDLSVTTPFIPINEQMVIDVHNVMTFGGNMITVTEASTV
                     FPQTFYLSGLFFFGPVNLSASTLTVPTITLTIGGPTVTVPISIVGALESRTITFLKID
                     PAPGIGNSTTNPSSGFFNSGTGGTSGFQNVGGGSSGVWNSGLSSAIGNSGFQNLGSLQ
                     SGWANLGNSVSGFFNTSTVNLSTPANVSGLNNIGTNLSGVFRGPTGTIFNAGLANLGQ
                     LNIGSANLGDFNLGSGNVGSFNVFSGNQGSYNIGPANLGNYNIGFANLGNYNIGFGNA
                     GDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGTANIGLFNSGTN
                     NVGIGNSGTGNWGIGNSGSGNTGIGNTGSTNTGFFNTGIVNTGVANAGSYNTGWYNTG
                     DTNTGIANLGDFNTGFYNTGNFSTGFANQGDIATGAFITGDMGNGAFWRGDQQGLFSA
                     GYRVHVPEIPAHVTVEVPVNIPITASFTNTVYSGITLEQINFGFTIDIAGIPLLAGAI
                     SKAVLPPITGTGPAITVNIGDPGGSTAIRIPATASVGPFDVTFVNIAATTGFFNATTD
                     PSSGFFNGGPGTVSGIANIGANISGFQNVANSATSGFNNYGSLQSGLANLGDTVSGVF
                     NTGIGAPANVSGMFNIGSNLAGFFHDQATGMSMFNLGLGNIGQFNVGFSNVGDSNAGL
                     ANIGSFNLGSGNLGSFNVFGGNQGSYNIGPANLGNYNIGLGNLGSYNFGFGNAGDFNL
                     GFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGSGNSGLFNSGTNNIGLF
                     NSGTGNIGIGNSGTGNWGIANTGDTNTGIFNTGDVNTGLLNAGNVNTGIFNTGHYNTG
                     SFNAGSFNTAGFNPGSYNTGYLNTGSYNTGLANSGDVNTGGFITGNYSNGFWWRGDYQ
                     GLAGISQTITVPDTAVPVKLHVPIFLDIPVTGTLGTFTVHGFRFPEITGDIFLIGIPF
                     NAATLDAFSFPNISIVLPNIGINLGSGPDPLIDIAGTGGLLPIKIPLIDIPAAPGFGN
                     STTTPSSGFFNAGTGTVSGVGNVGSNSSGFFNLTSGSSGISGVQNFGELISGGFNFGN
                     TVSGLVNASTLGLSMPANLSGGGNVGATVAGFVNNTQILNLGFGNVGSGNVGHGNIGD
                     SNVGLGNLGNANVGHGNIGSFNVFSGNRGSYNIGPANLGNYNIGLGNLGSYNFGFGNA
                     GDFNLGFANSGSNNIGFANTGNNNIGIGLSGHNQQGFGSWNSGTANTGLFNSGTNNIG
                     LFNSGTGNIGIGNSGIGNTGIGNPGVGNTGLGNSGTGNWGLWNPGTGNMGVANVGTYN
                     TGGYNVGSTNTGIANVGIANTGSYNTGSTNTGSFNDGDFNTGFYNTGDYNTGFYNTGD
                     VNTGAFIGGNFSNGAFWQSDHQGQWGAHYAITVPQIPLLNFSLNIPVNIPIHLDFGTL
                     AVNGFQIPAITLRALGVTHFSVGPIIVPRIAGTLPVIDINIGDPGGSSSIPITITSGA
                     GPVVIPLLDIPPAPGFGNSTTGPSSGFFNSGTGSSSGFGNVGANNSGFWNTAFAGIGN
                     SGLQNFGSLQSGWANLGNTVSGFYNTSAADFATPANLSGLSNVGADLTGVLRGPNGST
                     FNAGLANLGQFNVGSANLGSANLGSANLGSANLGNSNVGFGNIGNANIGGANIGDFNV
                     GIANTGPGLTAAVNNIGIGNTGNYNIGVGNTGNYNIGFGNTGNNNIGIGLSGDNQIGF
                     GPLNAGIANMGLFNLGDNNFGMANAGNFNQGIANTGNNNIGLFNTGNNNVGIGLTGDG
                     LSGFSSLNSGAGNTGFFNSGTANTGLFNSGTGNTGLFNSGTGNVGIGNMGTGGFGVGL
                     SGDSQVGIGGTNSGSFNIGLFNSGTGNVGIGNSGTGNVGIGNTGTGNTGIGNSGNYNT
                     GLLNAGLVNTGIANPGNHNTGLFNIGTFNTGIANPGHYNTGSYNTGSYNTGMANAGDY
                     GTGAFITGSMNNGLLWRADRQGLLAANYTITIERPAAFLNVDIPVNIPITGDITNVSI
                     PAITFPRIDASGSVDIGILSGTVLAPVGPITLHGGDASAPLDTPIEIDFGPSPAINLN
                     IGKPDGSTVINIVGGAGAGPISIPIIDLRPAPGFFNATTGPSSGFLNWGAGSASGLLN
                     FGNNSGLYNFATSSMGNSGFQNYGSLQSGWANLGNSISGIYNTGLGAPANVSGLLNIG
                     TNLAGWLQNGPTETTFSVGLANLGFWNLGSANIGNYNLGSANIGVYNLGSANIGDFNL
                     GSANIGDFNLGSANIGSSNIGFGNVGPGLTAAIGNIGFGNTGNGNIGIGNTGTGNIGF
                     GNTGNGNIGIGLTGDTMTGFGGWNSGTGNIGLFNSGTGNIGFGNSGTGNWGIGNSGDY
                     NTGIGNTGSTNSGFFNTGLVNTGIGNSGDYNTGLFNAGNTNTGSFNPGDYNTGGFNPG
                     NYNTGYFNPGNSNTGIANSGDVNTGAFNSGNYSNGFFWRGDYQGLGGFAYQSAVSEIP
                     WSYDRFQH"
     misc_feature    complement(434194..434667)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE family; Region: PPE; pfam00823"
                     /db_xref="CDD:307116"
     misc_feature    complement(<433462..>433713)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="Sec23/Sec24 beta-sandwich domain; Region: Sec23_BS;
                     cl26809"
                     /db_xref="CDD:331630"
     misc_feature    complement(432247..>433344)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(430915..>431847)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(<429943..>430731)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="hypothetical protein; Provisional; Region:
                     PHA02515"
                     /db_xref="CDD:107197"
     misc_feature    complement(429508..>430269)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(428050..>429126)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(427111..>427734)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE family; Region: PPE; cl27636"
                     /db_xref="CDD:332457"
     misc_feature    complement(426313..>427341)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     misc_feature    complement(424855..>425892)
                     /gene="PPE8"
                     /locus_tag="Rv0355c"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     gene            complement(434830..435474)
                     /locus_tag="Rv0356c"
                     /db_xref="GeneID:886490"
     CDS             complement(434830..435474)
                     /locus_tag="Rv0356c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214870.1"
                     /db_xref="GeneID:886490"
                     /translation="MTDASVHPDELDPEYHHHGGFPEYGPASPGAGFGQFVATMRRLQ
                     DLAVAADPGDAVWDEAAERAAALVELLSPFEADEGKAPAGRTPGLPGMGSLLLPPWTV
                     TRYGTDGVEMRGSFSRFHVGGNSAVHGGVLPLLFDHMFGMISHAAGRPISRTAFLHVD
                     YRRITPIDVPLIVRGRVTNTEGRKAFVCAELFDSDETLLAEGNGLMVRLLPGQP"
     misc_feature    complement(434851..435186)
                     /locus_tag="Rv0356c"
                     /note="PaaI_thioesterase is a tetrameric acyl-CoA
                     thioesterase with a hot dog fold and one of several
                     proteins responsible for phenylacetic acid (PA)
                     degradation in bacteria. Although orthologs of PaaI exist
                     in archaea and eukaryotes, their function has not...;
                     Region: PaaI_thioesterase; cd03443"
                     /db_xref="CDD:239527"
     misc_feature    complement(order(434983..434994,435013..435015,
                     435094..435096))
                     /locus_tag="Rv0356c"
                     /note="CoenzymeA binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:239527"
     misc_feature    complement(order(434992..434994,434998..435012,
                     435076..435078,435085..435087,435091..435093))
                     /locus_tag="Rv0356c"
                     /note="subunit interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:239527"
     misc_feature    complement(order(435013..435015,435049..435054,
                     435061..435066,435088..435090))
                     /locus_tag="Rv0356c"
                     /note="PHB binding site; other site"
                     /db_xref="CDD:239527"
     gene            complement(435471..436769)
                     /gene="purA"
                     /locus_tag="Rv0357c"
                     /db_xref="GeneID:886484"
     CDS             complement(435471..436769)
                     /gene="purA"
                     /locus_tag="Rv0357c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="imp--aspartate ligase (ADSS) (ampsase)"
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthetase"
                     /protein_id="NP_214871.1"
                     /db_xref="GeneID:886484"
                     /translation="MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVV
                     LPTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISAD
                     AHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHK
                     VEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETV
                     LLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSG
                     PFPTELFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDV
                     LSSLESVPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPA
                     KARDYVLRLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP"
     misc_feature    complement(435480..436769)
                     /gene="purA"
                     /locus_tag="Rv0357c"
                     /note="adenylosuccinate synthetase; Provisional; Region:
                     PRK01117"
                     /db_xref="CDD:234904"
     gene            436860..437507
                     /locus_tag="Rv0358"
                     /db_xref="GeneID:886493"
     CDS             436860..437507
                     /locus_tag="Rv0358"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214872.1"
                     /db_xref="GeneID:886493"
                     /translation="MYTAENAPGVAVLLSGDADVPGPLTGLPTHQDNLDTVIGRYSRL
                     IVVGADADLGAVLTRLLRTDRLDVEVGYVPRRRSPATRAYRLPAGRRAARRARCGVAR
                     RVPLIRDETGSVIVGRAQWLPAEEQALIHGEAVVDDTVLFDGDVAGVCIEPTLTLPGL
                     RAAVDGAGKWRRWIGGRAAQLGTTGAAVLRDGVAAPRPVRRSTFYRNVEGWLLVR"
     gene            437518..438297
                     /locus_tag="Rv0359"
                     /db_xref="GeneID:886482"
     CDS             437518..438297
                     /locus_tag="Rv0359"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00142"
                     /note="integral membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease"
                     /protein_id="NP_214873.1"
                     /db_xref="GeneID:886482"
                     /translation="MSETGQRESVRPSPIFLGLLGLTAVGGALAWLAGETVQPLAYAG
                     VFVMVIAGWLVSLCLHEFGHAFTAWRFGDHDVAVRGYLTLDPRRYSHPMLSLGLPMLF
                     IALGGIGLPGAAVYVHTWFMTTARRTLVSLAGPTVNLALAMLLLAATRLLFDPIHAVL
                     WAGVAFLAFLQLTALVLNLLPIPGLDGYAALEPHLRPETQRALAPAKQFALVFLLVLF
                     LAPTLNGWFFGVVYWLFDLSGVSHRLAAAGSVLARFWSIWF"
     misc_feature    437653..438141
                     /locus_tag="Rv0359"
                     /note="Uncharacterized homologs of Site-2 protease (S2P),
                     zinc metalloproteases (MEROPS family M50) which cleave
                     transmembrane domains of substrate proteins, regulating
                     intramembrane proteolysis (RIP) of diverse signal
                     transduction mechanisms. Members of the...; Region:
                     S2P-M50_like_1; cd06158"
                     /db_xref="CDD:100079"
     misc_feature    order(437695..437700,437707..437709,438049..438051,
                     438073..438075)
                     /locus_tag="Rv0359"
                     /note="active site"
                     /db_xref="CDD:100079"
     misc_feature    438049..438060
                     /locus_tag="Rv0359"
                     /note="putative substrate binding region [chemical
                     binding]; other site"
                     /db_xref="CDD:100079"
     gene            complement(438302..438739)
                     /locus_tag="Rv0360c"
                     /db_xref="GeneID:886480"
     CDS             complement(438302..438739)
                     /locus_tag="Rv0360c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214874.1"
                     /db_xref="GeneID:886480"
                     /translation="MTKRTITPMTSMGDLLGPEPILLPGDSDAEAELLANESPSIVAA
                     AHPSASVAWAVLAEGALADDKTVTAYAYARTGYHRGLDQLRRHGWKGFGPVPYSHQPN
                     RGFLRCVAALARAAAAIGETDEYGRCLDLLDDCDPAARPALGL"
     misc_feature    complement(438314..438694)
                     /locus_tag="Rv0360c"
                     /note="Protein of unknown function (DUF3151); Region:
                     DUF3151; pfam11349"
                     /db_xref="CDD:314320"
     gene            438822..439649
                     /locus_tag="Rv0361"
                     /db_xref="GeneID:886478"
     CDS             438822..439649
                     /locus_tag="Rv0361"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214875.1"
                     /db_xref="GeneID:886478"
                     /translation="MSNAPEPDRSAGESGSEPAGERSADPGEERTESYPLVPHDAETE
                     TVVITTSDNDAAVTQPEAQRERRFTAPGFDAKETQVIVTAHEAATEVFQTNQAPTTPP
                     RMPTGMPPKTAVPQSIPPRTEATSVRQRTWGWALAVVVIVLALAAIAILGTVLLTRGK
                     HSKMSQEDQVRQAIQSLDIAIQTGDLTALRSLTCGSTRDGYVDYDERDWAETYRRVSA
                     AKQYPVIASIDQVVVNGAHAEANVTTFMAFDPQVRSTRSLDLQFRDDQWKICQSSSN"
     misc_feature    439101..>439298
                     /locus_tag="Rv0361"
                     /note="Glycosyltransferase family A (GT-A) includes
                     diverse families of glycosyl transferases with a common
                     GT-A type structural fold; Region: Glyco_tranf_GTA_type;
                     cl11394"
                     /db_xref="CDD:325014"
     gene            439871..441253
                     /gene="mgtE"
                     /locus_tag="Rv0362"
                     /db_xref="GeneID:886476"
     CDS             439871..441253
                     /gene="mgtE"
                     /locus_tag="Rv0362"
                     /codon_start=1
                     /transl_table=11
                     /product="Mg2+ transport transmembrane protein MgtE"
                     /protein_id="NP_214876.1"
                     /db_xref="GeneID:886476"
                     /translation="MSIRPAENSTLDIRHVIGIGTPKAVDLWLDVVTELPDRARELGS
                     LSKAELGKLGPLLDGTNAVELFESIDDKLAAEALHAMDPSLAATFLEALDSDHAANIL
                     REFKEPKREALLTLLPLERAMVLRGLLSWPEDCAAAHMVPETLTVRPNMTVSQAVASV
                     RERASGLRSDARTTAYVYVTDADSHLLGVIAFRALVLANPEQRVRELMGDDLIVVSPL
                     TDKELAAQTIMGHNLMAVPVVDADNRLLGIIAEDEAIDIAEEEATEDAERQGGSAPLE
                     VPYLRASPWLLWRKRVVWLLVLFAAEAYTGSVLRAFSDEMEAVIALAFFIPLLIGTGG
                     NTGTQIATTLVRAMATGQVRFRDVPAVLAKELSTGVLVGLTMAAAAVVRAWTLGVGPQ
                     VTLTVALTVAAIVVWSSLVAAVLPPLLKKLRIDPAIVSGPMIATIVDGTGLLIYFLVA
                     HLTLTELHGL"
     misc_feature    439883..441244
                     /gene="mgtE"
                     /locus_tag="Rv0362"
                     /note="Mg/Co/Ni transporter MgtE (contains CBS domain)
                     [Inorganic ion transport and metabolism]; Region: MgtE;
                     COG2239"
                     /db_xref="CDD:225148"
     gene            complement(441265..442299)
                     /gene="fba"
                     /locus_tag="Rv0363c"
                     /gene_synonym="fda"
                     /db_xref="GeneID:886474"
     CDS             complement(441265..442299)
                     /gene="fba"
                     /locus_tag="Rv0363c"
                     /gene_synonym="fda"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to class II fructose-bisphosphate aldolase
                     family. Cofactor: zinc."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-bisphosphate aldolase"
                     /protein_id="NP_214877.1"
                     /db_xref="GeneID:886474"
                     /translation="MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADA
                     GSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKL
                     DSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEI
                     EIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPG
                     NVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVD
                     TDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACND
                     LHCAGKSLTH"
     misc_feature    complement(441274..442299)
                     /gene="fba"
                     /locus_tag="Rv0363c"
                     /gene_synonym="fda"
                     /note="fructose-bisphosphate aldolase; Provisional;
                     Region: PRK09197"
                     /db_xref="CDD:236406"
     gene            442395..443078
                     /locus_tag="Rv0364"
                     /db_xref="GeneID:886473"
     CDS             442395..443078
                     /locus_tag="Rv0364"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214878.1"
                     /db_xref="GeneID:886473"
                     /translation="MSTAVTAMPDILDPMYWLGANGVFGSAVLPGILIIVFIETGLLF
                     PLLPGESLLFTGGLLSASPAPPVTIGVLAPCVALVAVLGDQTAYFIGRRIGPALFKKE
                     DSRFFKKHYVTESHAFFEKYGKWTIILARFVPIARTFVPVIAGVSYMRYPVFLGFDIV
                     GGVAWGAGVTLAGYFLGSVPFVHMNFQLIILAIVFVSLLPALVSAARVYRARRNAPQS
                     DPDPLVLPE"
     misc_feature    442464..443039
                     /locus_tag="Rv0364"
                     /note="SNARE associated Golgi protein; Region:
                     SNARE_assoc; cl00429"
                     /db_xref="CDD:320969"
     gene            complement(443067..444197)
                     /locus_tag="Rv0365c"
                     /db_xref="GeneID:886487"
     CDS             complement(443067..444197)
                     /locus_tag="Rv0365c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214879.1"
                     /db_xref="GeneID:886487"
                     /translation="MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLF
                     GSWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLA
                     LALERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFL
                     ARYPDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLE
                     TELAVRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALV
                     ATTLPGDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGE
                     QARSVRGAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG"
     misc_feature    complement(443070..444185)
                     /locus_tag="Rv0365c"
                     /note="Predicted alpha-1,6-mannanase, GH76 family
                     [Carbohydrate transport and metabolism]; Region: COG4833"
                     /db_xref="CDD:227170"
     gene            complement(444222..444815)
                     /locus_tag="Rv0366c"
                     /db_xref="GeneID:886471"
     CDS             complement(444222..444815)
                     /locus_tag="Rv0366c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00850"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214880.1"
                     /db_xref="GeneID:886471"
                     /translation="MKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWP
                     DDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSHPSKLELIRTARTAGYTVVLHVL
                     VIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
                     PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA"
     misc_feature    complement(444255..444815)
                     /locus_tag="Rv0366c"
                     /note="Predicted ABC-type ATPase [General function
                     prediction only]; Region: COG4185"
                     /db_xref="CDD:226648"
     gene            complement(444844..445233)
                     /locus_tag="Rv0367c"
                     /db_xref="GeneID:886468"
     CDS             complement(444844..445233)
                     /locus_tag="Rv0367c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214881.1"
                     /db_xref="GeneID:886468"
                     /translation="MPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAV
                     SNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEISAAIEERLSRTNYGDVLAAQGI
                     TTVALNDAGDIVEHRPDGTSVVLAATP"
     misc_feature    complement(444913..445218)
                     /locus_tag="Rv0367c"
                     /note="ParD-like antitoxin of type II bacterial
                     toxin-antitoxin system; Region: ParD_like; pfam11903"
                     /db_xref="CDD:314732"
     gene            complement(445314..446525)
                     /locus_tag="Rv0368c"
                     /db_xref="GeneID:886469"
     CDS             complement(445314..446525)
                     /locus_tag="Rv0368c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /inference="protein motif:PROSITE:PS00213"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214882.1"
                     /db_xref="GeneID:886469"
                     /translation="MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQ
                     LVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRT
                     PVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPF
                     DQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLL
                     ARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLT
                     SVLSHRSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDS
                     DPPDVLVHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGL
                     HQLLLALAGAR"
     misc_feature    complement(445317..446525)
                     /locus_tag="Rv0368c"
                     /note="Uncharacterized conserved protein, contains von
                     Willebrand factor type A (vWA) domain [Function unknown];
                     Region: CoxE; COG3552"
                     /db_xref="CDD:226082"
     gene            complement(446531..447046)
                     /locus_tag="Rv0369c"
                     /db_xref="GeneID:886485"
     CDS             complement(446531..447046)
                     /locus_tag="Rv0369c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane oxidoreductase"
                     /protein_id="NP_214883.1"
                     /db_xref="GeneID:886485"
                     /translation="MPGAQLIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHR
                     AVFDAKGKEARGTGNAAATVAAQLHEVGERTRVTVDTDLKIVGKLAQFGSGMLQQVSE
                     KLLGQFVDSLEAELAAQSSESPQGTPPATEAAPIDLLQLADGGQLKKYGSALLAALTV
                     LLLIWVLRRRR"
     misc_feature    complement(446693..447046)
                     /locus_tag="Rv0369c"
                     /note="Ligand-binding SRPBCC domain of an uncharacterized
                     subfamily of proteins; Region: SRPBCC_5; cd07823"
                     /db_xref="CDD:176865"
     gene            complement(447147..448043)
                     /locus_tag="Rv0370c"
                     /db_xref="GeneID:886465"
     CDS             complement(447147..448043)
                     /locus_tag="Rv0370c"
                     /inference="protein motif:PROSITE:PS00017"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="NP_214884.1"
                     /db_xref="GeneID:886465"
                     /translation="MTFASPDDVIRRFDEQNYLLDTGTASAIYLAVTLGRPLLLEGEP
                     GVGKTTAAKTLAVVLDTTLIRLQCYEGLTANEALYDWNYQRQLLSIRLAEARGKGISD
                     ISEADLYTEAYLVDRPILRCVRHRGPTPPVLLIDEIDRADDEFEALLLEFLGESAVTV
                     PELGTFLAECPPIAVLTSNRSRDLHDALRRRCLYHWIDYPGPDRAAAIVRRTVPGATA
                     PLIENATQFVCTARDLDLDKPPGVAETIDWVAALVALGVADLTAADSSPALASLGALA
                     KTPDDRTQIRDAYQAFTECSHA"
     misc_feature    complement(447150..448043)
                     /locus_tag="Rv0370c"
                     /note="MoxR-like ATPase [General function prediction
                     only]; Region: MoxR; COG0714"
                     /db_xref="CDD:223786"
     gene            complement(448040..448633)
                     /locus_tag="Rv0371c"
                     /db_xref="GeneID:886463"
     CDS             complement(448040..448633)
                     /locus_tag="Rv0371c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214885.1"
                     /db_xref="GeneID:886463"
                     /translation="MTATQITGVVLAAGRSNRLGTPKQLLPYRDTTVLGATLDVARQA
                     GFDQLILTLGGAASAVRAAMALDGTDVVVVEDVERGCAASLRVALARVHPRATGIVLM
                     LGDQPQVAPATLRRIIDVGPATEIMVCRYADGVGHPFWFSRTVFGELARLHGDKGVWK
                     LVHSGRHPVRELAVDGCVPLDVDTWDDYRRLLESVPS"
     misc_feature    complement(448043..448633)
                     /locus_tag="Rv0371c"
                     /note="CTP:molybdopterin cytidylyltransferase MocA
                     [Coenzyme transport and metabolism]; Region: MocA;
                     COG2068"
                     /db_xref="CDD:224979"
     misc_feature    complement(order(448319..448321,448595..448597,
                     448601..448603))
                     /locus_tag="Rv0371c"
                     /note="Ligand binding site; other site"
                     /db_xref="CDD:133025"
     misc_feature    complement(order(448085..448087,448091..448093,
                     448319..448321))
                     /locus_tag="Rv0371c"
                     /note="metal-binding site"
                     /db_xref="CDD:133025"
     gene            complement(448630..449385)
                     /locus_tag="Rv0372c"
                     /db_xref="GeneID:886460"
     CDS             complement(448630..449385)
                     /locus_tag="Rv0372c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214886.1"
                     /db_xref="GeneID:886460"
                     /translation="MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGT
                     IEGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGS
                     LEIFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASH
                     GGPEAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTP
                     AEIAVSIAAELIATLRGGGPRGRKALADENGGA"
     misc_feature    complement(448636..449385)
                     /locus_tag="Rv0372c"
                     /note="Xanthine and CO dehydrogenase maturation factor,
                     XdhC/CoxF family [Posttranslational modification, protein
                     turnover, chaperones]; Region: XdhC; COG1975"
                     /db_xref="CDD:224886"
     gene            complement(449404..451803)
                     /locus_tag="Rv0373c"
                     /db_xref="GeneID:886472"
     CDS             complement(449404..451803)
                     /locus_tag="Rv0373c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbon monoxyde dehydrogenase large subunit"
                     /protein_id="NP_214887.1"
                     /db_xref="GeneID:886472"
                     /translation="MTTIESRPPSPEDLADNAQQPCGHGRMMRKEDPRFIRGRGTYVD
                     DVALPGMLHLAILRSPYAHARIVRIDVTAAQAHPKVKAVVTGADLAAKGLAWMPTLAN
                     DVQAVLATDKTRFQGQEVAFVVAEDRYSARDACELVDVDYEPRDPVVDARTALDPSAP
                     VIRTDLEGKSDNHIFDWETGDAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVAD
                     LDPVTGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKVPIYPGYVC
                     AIVASLLLDKPVKWMEDRSENLTSTGFARDYIMVGEIAANRDGKILAIRSNVLADHGA
                     FNAQAAPAKYPAGFFGVFTGSYDIEAAYCHMTAVYTNKAPGGVAYACSFRITEAVYFV
                     ERLVDCLAFELKMDPAELRLRNLLRPNQFPYQSKTGWVYDSGDYETTMRKAMNMIGYE
                     ALRAEQKQRRARGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVL
                     RLSVQTQGQGHETTFAQIVAEELGIAPDDIEVVHGDTDQTPFGLGTYGSRSTPVSGGA
                     AALVARKVRDKAKIIASGMLEVSVADLQWEKGKFHVKGDPSAAVTIADIAMRAHGAGD
                     LPEGIEGGLDAEVCYNPSNLTYPYGAYFCVVDIDPGTAVVKVRRFLAVDDCGTRINPM
                     IIEGQVHGGIVDGIGMALMEMIAFDEDGNCLGGSLMDYLIPTALEVPHLETGHTVTPS
                     PHHPIGAKGIGESATVGSPPAVVNAVVDALAPFGVRHADMPLTPSRVWEAMQGRATPP
                     I"
     misc_feature    complement(449434..451713)
                     /locus_tag="Rv0373c"
                     /note="Molybdopterin-binding domain of aldehyde
                     dehydrogenase; Region: Ald_Xan_dh_C2; cl27380"
                     /db_xref="CDD:332201"
     gene            complement(451800..452279)
                     /locus_tag="Rv0374c"
                     /db_xref="GeneID:886462"
     CDS             complement(451800..452279)
                     /locus_tag="Rv0374c"
                     /codon_start=1
                     /transl_table=11
                     /product="carbon monoxyde dehydrogenase small subunit"
                     /protein_id="NP_214888.1"
                     /db_xref="GeneID:886462"
                     /translation="MQVNMTVNGEPVTAEVEPRMLLVHFLRDQLRLTGTHWGCDTSNC
                     GTCVVEVDGVPVKSCTMLAVMASGHSIRTVEGLAGPDGQLDPVQEGFMRCHGLQCGFC
                     TPGMLITARALLDRNPDPDEQTIREAISGQICRCTGYTTIVRSIQWAAAHQTVKAQS"
     misc_feature    complement(451821..452279)
                     /locus_tag="Rv0374c"
                     /note="Aerobic-type carbon monoxide dehydrogenase, small
                     subunit, CoxS/CutS family [Energy production and
                     conversion]; Region: CoxS; COG2080"
                     /db_xref="CDD:224991"
     gene            complement(452294..453154)
                     /locus_tag="Rv0375c"
                     /db_xref="GeneID:886456"
     CDS             complement(452294..453154)
                     /locus_tag="Rv0375c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbon monoxyde dehydrogenase medium subunit"
                     /protein_id="NP_214889.1"
                     /db_xref="GeneID:886456"
                     /translation="MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEYLVDINDL
                     APELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIFRDAERVIADPVVRNRG
                     TLGGSLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAIDDFLVGPYETALAHNEVLI
                     EVRIPLRHNTSSAYAKVERRVGDWAITAAGAAVTLDGQTILAARVGLTAVNPDPVALA
                     ELSAGLVGQPATEEVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGR
                     VLGAPAAPEA"
     misc_feature    complement(452327..453151)
                     /locus_tag="Rv0375c"
                     /note="CO or xanthine dehydrogenase, FAD-binding subunit
                     [Energy production and conversion]; Region: CoxM; COG1319"
                     /db_xref="CDD:224238"
     gene            complement(453230..454372)
                     /locus_tag="Rv0376c"
                     /db_xref="GeneID:886454"
     CDS             complement(453230..454372)
                     /locus_tag="Rv0376c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214890.1"
                     /db_xref="GeneID:886454"
                     /translation="MAIWAAGDTAGVATVVRTLRSAPRPPGAAMVVAPDGSVSGSVSG
                     GCVEGAVYELAAEVAQTGIPRLEHYGVSDDTAFAVGLTCGGIIDVFVEPVSRATFPEL
                     GELADDIGAQRPVAIATVIAHPDERRVGRRLVIRPDTKSPVTGSLGSARADAAVIDDA
                     RGLLAVGRSEILEYGPDGQRRGEGMEVFVSSHAPRPRMLVFGAIDFAAALARQGSFLG
                     YRVTVCDARAVFATPARFPTADDVVVAWPHRYLAAQAEAGGIDERTVICVLTHDPKFD
                     VPVLEVALRLGVGYVGAMGSRKTHDDRMDRLRAAGLTDAELSRLSSPIGLDLGARTPE
                     ETAVSIAADIIARRWGGGGRPLADIAGRIHHDAQVAGEFKDYLTRH"
     misc_feature    complement(453266..454360)
                     /locus_tag="Rv0376c"
                     /note="Xanthine and CO dehydrogenase maturation factor,
                     XdhC/CoxF family [Posttranslational modification, protein
                     turnover, chaperones]; Region: XdhC; COG1975"
                     /db_xref="CDD:224886"
     misc_feature    complement(453341..453781)
                     /locus_tag="Rv0376c"
                     /note="XdhC Rossmann domain; Region: XdhC_C; pfam13478"
                     /db_xref="CDD:316039"
     gene            454421..455386
                     /locus_tag="Rv0377"
                     /db_xref="GeneID:886452"
     CDS             454421..455386
                     /locus_tag="Rv0377"
                     /inference="protein motif:PROSITE:PS00044"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_214891.1"
                     /db_xref="GeneID:886452"
                     /translation="MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMHVAALRKELD
                     DPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTAIEVTEAAHGRRLLRIAASSAFAE
                     HAAPGLIELFSSRADDLSVELSVHPTSRFRELICSRAVDIAIGPASESSIGSDGSIFL
                     RPFLKYQIITVVAPNSPLAAGIPMPALLRHQQWMLGPSAGSVDGEIATMLRGLAIPES
                     QQRIFQSDAAALEEVMRVGGATLAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLA
                     PSARQPAVSELVGFISTPRCIQAMIPGSGVGVTRFRPKVHVTLWS"
     misc_feature    454421..455293
                     /locus_tag="Rv0377"
                     /note="DNA-binding transcriptional regulator, LysR family
                     [Transcription]; Region: LysR; COG0583"
                     /db_xref="CDD:223656"
     gene            455637..455858
                     /locus_tag="Rv0378"
                     /db_xref="GeneID:886450"
     CDS             455637..455858
                     /locus_tag="Rv0378"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214892.1"
                     /db_xref="GeneID:886450"
                     /translation="MSGRWEAGNADGNGGSAGLIGSGGAGGDGGSGGATGAGGEGGDA
                     GASGSINGNAGDPGNSGERGAVGKPGAPG"
     gene            455977..456192
                     /gene="secE2"
                     /locus_tag="Rv0379"
                     /db_xref="GeneID:886449"
     CDS             455977..456192
                     /gene="secE2"
                     /locus_tag="Rv0379"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Could be a part of the prokaryotic protein
                     translocation apparatus which comprise SECA|Rv3240c,
                     SECD|Rv2587c,SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 and
                     SECY|Rv0732."
                     /codon_start=1
                     /transl_table=11
                     /product="protein translocase subunit SecE"
                     /protein_id="YP_177722.1"
                     /db_xref="GeneID:886449"
                     /translation="MSVYKVIDIIGTSPTSWEQAAAEAVQRARDSVDDIRVARVIEQD
                     MAVDSAGKITYRIKLEVSFKMRPAQPR"
     misc_feature    455977..456183
                     /gene="secE2"
                     /locus_tag="Rv0379"
                     /note="Flavin-binding protein dodecin [General function
                     prediction only]; Region: COG3360"
                     /db_xref="CDD:225896"
     gene            complement(456268..456819)
                     /locus_tag="Rv0380c"
                     /db_xref="GeneID:886446"
     CDS             complement(456268..456819)
                     /locus_tag="Rv0380c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="NP_214894.1"
                     /db_xref="GeneID:886446"
                     /translation="MLLRDGDARNVVDAYRYWTREAIIADIDTRRHPLHVAIENFGHD
                     ANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTTGLLEFAAGAGL
                     TVVAVDNVPGAARLEQTALPRECLLLFGQEGPGITDDARAGAAVTVSIAQFGSTRSIN
                     AGVAAGIAMHAWIRQHADLGRAW"
     misc_feature    complement(456283..>456801)
                     /locus_tag="Rv0380c"
                     /note="tRNA G18 (ribose-2'-O)-methylase SpoU [Translation,
                     ribosomal structure and biogenesis]; Region: SpoU;
                     COG0566"
                     /db_xref="CDD:223640"
     gene            complement(456915..457823)
                     /locus_tag="Rv0381c"
                     /db_xref="GeneID:886444"
     CDS             complement(456915..457823)
                     /locus_tag="Rv0381c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214895.1"
                     /db_xref="GeneID:886444"
                     /translation="MRILVAWATCGAVVLSGLTGCSGSSHSGRTYGAQSARTGESLAV
                     LGWNMSVSNLRWSGDYVLIDVDASPTDPHAPHAKPEDIRFGLYGALAHPMESAALGSC
                     GDAMAHVRDVVSPLSAPAGRLTGTVCLGPLKERSAVRGVYTYSPRDRIPGTAAAYPAA
                     FPVGMLPTNQNDAGLVVKTTSVSAWRADGMQLGKPQLGDPVAFTGNGYMLLGLEVDAV
                     PDRYRDDSAARGGPMMLLAAPTLPGRGLSPACATYGSSVLILPDALLDAVHISASLCT
                     QGEINEALLYATVATVGTHAALWTSR"
     gene            complement(457841..458380)
                     /gene="pyrE"
                     /locus_tag="Rv0382c"
                     /gene_synonym="umpA"
                     /db_xref="GeneID:886443"
     CDS             complement(457841..458380)
                     /gene="pyrE"
                     /locus_tag="Rv0382c"
                     /gene_synonym="umpA"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00589"
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="YP_177723.1"
                     /db_xref="GeneID:886443"
                     /translation="MAGPDRAELAELVRRLSVVHGRVTLSSGREADYYVDLRRATLHH
                     RASALIGRLMRELTADWDYSVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKAHGM
                     QRLIEGSEVTGQRVLVVEDTSTTGNSALTAVHAVQDVGGEVVGVATVVDRATGAAEAI
                     EAEGLRYRSVLGLADLGLD"
     misc_feature    complement(457853..458365)
                     /gene="pyrE"
                     /locus_tag="Rv0382c"
                     /gene_synonym="umpA"
                     /note="orotate phosphoribosyltransferase; Validated;
                     Region: pyrE; PRK00455"
                     /db_xref="CDD:234771"
     misc_feature    complement(order(457925..457927,457997..458011,
                     458015..458023,458165..458167,458171..458173))
                     /gene="pyrE"
                     /locus_tag="Rv0382c"
                     /gene_synonym="umpA"
                     /note="active site"
                     /db_xref="CDD:206754"
     gene            complement(458461..459315)
                     /locus_tag="Rv0383c"
                     /db_xref="GeneID:886458"
     CDS             complement(458461..459315)
                     /locus_tag="Rv0383c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214897.1"
                     /db_xref="GeneID:886458"
                     /translation="MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFD
                     YERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGT
                     NVVVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAE
                     IMWNEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAA
                     PGRPVAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNG
                     QQATNYQH"
     misc_feature    complement(458464..>458748)
                     /locus_tag="Rv0383c"
                     /note="Proline-rich; Region: Pro-rich; pfam15240"
                     /db_xref="CDD:291893"
     gene            complement(459456..462002)
                     /gene="clpB"
                     /locus_tag="Rv0384c"
                     /gene_synonym="htpM"
                     /db_xref="GeneID:886440"
     CDS             complement(459456..462002)
                     /gene="clpB"
                     /locus_tag="Rv0384c"
                     /gene_synonym="htpM"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00870"
                     /inference="protein motif:PROSITE:PS00871"
                     /note="heat shock protein F84.1; endopeptidase ATP binding
                     protein ClpB"
                     /codon_start=1
                     /transl_table=11
                     /product="chaperone protein ClpB"
                     /protein_id="NP_214898.1"
                     /db_xref="GeneID:886440"
                     /translation="MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDG
                     IAAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQPQLSRESLAAITTAQQLATELD
                     DEYVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQA
                     LQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEG
                     LAQRIVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITF
                     IDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEYRKHIEKDAALERRF
                     QQVYVGEPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAI
                     DLVDEAASRLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELA
                     DQKEKLAELTTRWQNEKNAIEIVRDLKEQLEALRGESERAERDGDLAKAAELRYGRIP
                     EVEKKLDAALPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMED
                     ELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFL
                     FDDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIE
                     KAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTSNLGSGGSAEQVLAAVRATFK
                     PEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGF
                     DPVYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG"
     misc_feature    complement(459480..461930)
                     /gene="clpB"
                     /locus_tag="Rv0384c"
                     /gene_synonym="htpM"
                     /note="C-terminal, D2-small domain, of ClpB protein;
                     Region: ClpB_D2-small; cl26527"
                     /db_xref="CDD:331348"
     gene            462135..463307
                     /locus_tag="Rv0385"
                     /db_xref="GeneID:886441"
     CDS             462135..463307
                     /locus_tag="Rv0385"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="monooxygenase"
                     /protein_id="NP_214899.1"
                     /db_xref="GeneID:886441"
                     /translation="MGLEDRDALRVLQNAFKLDDPELVRRFYAHWFALDASVRDLFPP
                     DMGAQRAAFGQALHWVYGELVAQRAEEPVAFLAQLGRDHRKYGVLPTQYDTLRRALYT
                     TLRDYLGHPSRGAWTDAVDEAAGQSLNLIIGVMSGAADADDAPAWWDGTVVEHIRVSR
                     DLAVARLQLDRPLHYYPGQYVNVHVPQCPRRWRYLSPAIPADPNGRIEFHVRVVPGGL
                     VSNAIVGETRPGDRWRLSGPHGAFRVDRDGGDVLMVAGSTGLAPLRALIIDLSRFAVN
                     PRVHLFFGARYACELYDLPTLWQIAAHNPWLSVSPVSEYNGDPAWAADYPDVSAPRGL
                     HVRQTGRLPDVVSRYGGWGDRQILICGGPAMVRATKAALIAKGAPPERIQHDPLSR"
     misc_feature    462168..462539
                     /locus_tag="Rv0385"
                     /note="myoglobin_like; M family globin domain; Region:
                     Mb_like; cd01040"
                     /db_xref="CDD:271266"
     misc_feature    order(462255..462260,462279..462281,462288..462293,
                     462300..462302,462369..462371,462378..462383,
                     462396..462398,462408..462413,462420..462422)
                     /locus_tag="Rv0385"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:271266"
     misc_feature    462588..463295
                     /locus_tag="Rv0385"
                     /note="The oxygenase reductase FAD/NADH binding domain
                     acts as part of the multi-component bacterial oxygenases
                     which oxidize hydrocarbons using oxygen as the oxidant.
                     Electron transfer is from NADH via FAD (in the oxygenase
                     reductase) and an [2FE-2S]...; Region:
                     O2ase_reductase_like; cd06187"
                     /db_xref="CDD:99784"
     misc_feature    order(462672..462674,462711..462722,462762..462770,
                     462774..462776,462786..462794,462906..462908,
                     462915..462917,463290..463292)
                     /locus_tag="Rv0385"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99784"
     misc_feature    order(462711..462713,462717..462722)
                     /locus_tag="Rv0385"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99784"
     misc_feature    order(462783..462785,462792..462794,462801..462803,
                     462822..462824,462846..462848,462852..462854)
                     /locus_tag="Rv0385"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99784"
     misc_feature    order(462891..462893,462903..462914,462918..462920)
                     /locus_tag="Rv0385"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99784"
     misc_feature    order(462906..462911,462984..462992,463215..463220)
                     /locus_tag="Rv0385"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99784"
     gene            463411..466668
                     /locus_tag="Rv0386"
                     /db_xref="GeneID:886030"
     CDS             463411..466668
                     /locus_tag="Rv0386"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00622"
                     /note="Belongs to the LuxR/UhpA family of transcriptional
                     regulators."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214900.1"
                     /db_xref="GeneID:886030"
                     /translation="MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSG
                     VIAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALR
                     DEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSR
                     PERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVT
                     LTGAGGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRS
                     TTDTVLRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEV
                     SYRVPSLSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAAR
                     LRSMTLDEIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAV
                     FVGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYA
                     LEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNR
                     ENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADK
                     ALLDIFVDAAAGMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAE
                     AIDLARAVDDRWRLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCR
                     WCLGYAQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARA
                     AADAALEAAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQ
                     RAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAH
                     KALACAAESGAHLDLPDVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYR
                     SDYVQSVTALRDAMGEKDFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPT
                     EIDVVRLVGEGLANKDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT"
     misc_feature    463435..463941
                     /locus_tag="Rv0386"
                     /note="Adenylate cyclase, class 3 [Signal transduction
                     mechanisms]; Region: AcyC; COG2114"
                     /db_xref="CDD:225025"
     misc_feature    464014..465240
                     /locus_tag="Rv0386"
                     /note="Predicted ATPase [General function prediction
                     only]; Region: COG3903"
                     /db_xref="CDD:226418"
     misc_feature    466480..466653
                     /locus_tag="Rv0386"
                     /note="helix_turn_helix, Lux Regulon; Region: HTH_LUXR;
                     smart00421"
                     /db_xref="CDD:197715"
     misc_feature    order(466492..466500,466537..466545,466567..466572,
                     466576..466581,466585..466599,466630..466632)
                     /locus_tag="Rv0386"
                     /note="DNA binding residues [nucleotide binding]"
                     /db_xref="CDD:99777"
     misc_feature    order(466525..466527,466531..466533,466537..466539,
                     466630..466638,466645..466647,466654..466659)
                     /locus_tag="Rv0386"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:99777"
     gene            complement(466672..468001)
                     /locus_tag="Rv0387c"
                     /pseudogene="unknown"
                     /db_xref="GeneID:886436"
     gene            468335..469594
                     /gene="purT"
                     /locus_tag="Rv0389"
                     /db_xref="GeneID:886032"
     CDS             468335..469594
                     /gene="purT"
                     /locus_tag="Rv0389"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="gar transformylase 2 (5'-phosphoribosylglycinamide
                     transformylase 2) (formate-dependent gar transformylase).
                     Belongs to the PurK / PurT family. Cofactor: magnesium."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase
                     PurT"
                     /protein_id="NP_214903.1"
                     /db_xref="GeneID:886032"
                     /translation="MIDGWTEEQHEPTVRHERPAAPQDVRRVMLLGSAEPSRELAIAL
                     QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVD
                     ALDAVEQADGECTELVPNARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLGELQAV
                     AVHAGFPLLVSPVAGVAGQGSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESV
                     VEIEFLVTMIVVCSQGPNGPLIEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIA
                     ARIVKALGGRGVFGVELMINGDEVYFADVTVCPAGSAWVTVRSQRLSVFELQARAILG
                     LAVDTLMISPGAARVINPDHTAGRAAVGAAPPADALTGALGVPESDVVIFGRGLGVAL
                     ATAPEVAIARERAREVASRLNVPDSRE"
     misc_feature    468371..469582
                     /gene="purT"
                     /locus_tag="Rv0389"
                     /note="Formate-dependent phosphoribosylglycinamide
                     formyltransferase (GAR transformylase) [Nucleotide
                     transport and metabolism]; Region: PurT; COG0027"
                     /db_xref="CDD:223106"
     gene            469591..470013
                     /locus_tag="Rv0390"
                     /db_xref="GeneID:886433"
     CDS             469591..470013
                     /locus_tag="Rv0390"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214904.1"
                     /db_xref="GeneID:886433"
                     /translation="MSYAGDITPLQAWEMLSDNPRAVLVDVRCEAEWRFVGVPDLSSL
                     GREVVYVEWATSDGTHNDNFLAELRDRIPADADQHERPVIFLCRSGNRSIGAAEVATE
                     AGITPAYNVLDGFEGHLDAEGHRGATGWRAVGLPWRQG"
     misc_feature    469609..469986
                     /locus_tag="Rv0390"
                     /note="Member of the Rhodanese Homology Domain
                     superfamily, subgroup 1. This CD includes the putative
                     rhodanese-related sulfurtransferases of several
                     uncharacterized proteins; Region: RHOD_1; cd01522"
                     /db_xref="CDD:238780"
     misc_feature    469849..469851
                     /locus_tag="Rv0390"
                     /note="active site residue [active]"
                     /db_xref="CDD:238780"
     gene            470010..471230
                     /gene="metZ"
                     /locus_tag="Rv0391"
                     /db_xref="GeneID:886431"
     CDS             470010..471230
                     /gene="metZ"
                     /locus_tag="Rv0391"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="OSH sulfhydrylase. Belongs to the trans-sulfuration
                     enzymes family."
                     /codon_start=1
                     /transl_table=11
                     /product="O-succinylhomoserine sulfhydrylase"
                     /protein_id="NP_214905.1"
                     /db_xref="GeneID:886431"
                     /translation="MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTS
                     GYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVF
                     TSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQ
                     AVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGT
                     KHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHS
                     NASAQRIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQ
                     RAFEVLDKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLE
                     DTDDLIADIDRALS"
     misc_feature    470019..471227
                     /gene="metZ"
                     /locus_tag="Rv0391"
                     /note="O-succinylhomoserine sulfhydrylase; Provisional;
                     Region: PRK07810"
                     /db_xref="CDD:236103"
     misc_feature    order(470133..470144,470148..470153,470208..470210,
                     470214..470216,470292..470297,470301..470306,
                     470373..470375,470388..470390,470397..470399,
                     470661..470663,470685..470687,470691..470693,
                     470742..470744,470772..470774,470778..470783,
                     471030..471032)
                     /gene="metZ"
                     /locus_tag="Rv0391"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:99738"
     misc_feature    order(470295..470303,470373..470375,470502..470504,
                     470589..470591,470655..470657,470661..470666,
                     470691..470693)
                     /gene="metZ"
                     /locus_tag="Rv0391"
                     /note="substrate-cofactor binding pocket; other site"
                     /db_xref="CDD:99738"
     misc_feature    order(470295..470303,470373..470375,470589..470591,
                     470598..470600,470655..470657,470661..470666)
                     /gene="metZ"
                     /locus_tag="Rv0391"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:99738"
     misc_feature    470664..470666
                     /gene="metZ"
                     /locus_tag="Rv0391"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99738"
     gene            complement(471227..472639)
                     /gene="ndhA"
                     /locus_tag="Rv0392c"
                     /db_xref="GeneID:886430"
     CDS             complement(471227..472639)
                     /gene="ndhA"
                     /locus_tag="Rv0392c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADH dehydrogenase NdhA"
                     /protein_id="NP_214906.1"
                     /db_xref="GeneID:886430"
                     /translation="MTLSSGEPSAVGGRHRVVIIGSGFGGLNAAKALKRADVDITLIS
                     KTTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGEVNAIDLKAQTVTSK
                     LMDMTTVTPYDSLIVAAGAQQSYFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEV
                     STDHAERERRLTFVVVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAP
                     AVLPPMGPKLGLKAQRRLEKMDVEVQLNAMVTAVDYKGITIKEKDGGERRIECACKVW
                     AAGVAASPLGKMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVGDLMFVPGVPGVA
                     QGAIQGARYATTVIKHMVKGNDDPANRKPFHYFNKGSMATISRHSAVAQVGKLEFAGY
                     FAWLAWLVLHLVYLVGYRNRIAALFAWGISFMGRARGQMAITSQMIYARLVMTLMEQQ
                     AQGALAAAEQAEHAEQEAAG"
     misc_feature    complement(471350..472600)
                     /gene="ndhA"
                     /locus_tag="Rv0392c"
                     /note="NADH dehydrogenase, FAD-containing subunit [Energy
                     production and conversion]; Region: Ndh; COG1252"
                     /db_xref="CDD:224172"
     gene            472781..474106
                     /locus_tag="Rv0393"
                     /db_xref="GeneID:886428"
     CDS             472781..474106
                     /locus_tag="Rv0393"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214907.1"
                     /db_xref="GeneID:886428"
                     /translation="MAVGRCAIPRFDQAASGSAINGGQVHLSDGSTSPARQLPAPWPG
                     DAGAAAEGRAGVCCRGNRLPHVSDVGVSHRFDHRPAGVGAGGCRAGAAGAGLAVDDPG
                     QLAAAIDRIVAVADPDAVRQVRERARDREVSIWNSADGMGEVYAQLYATDAQALDARL
                     NALVATVCAGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVSAVVIHVVA
                     EQASVKGHGQAPAALLGGDGLIPAELVAELAKTAGLQPIPVPAGTEPGYRPSVKLAAF
                     VRARDLTCRAPGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCGWRAQ
                     QLPDGTVIWTLPGNQTYVTTPGSALLFPALCTPTGDPPAPEPARADRRGQRTAMMPRR
                     ASTRTQNRAHCIAAERHRNHQARRIAQAAVIATETHGPPPDPDDDPPPF"
     misc_feature    <473078..473623
                     /locus_tag="Rv0393"
                     /note="Domain of unknown function (DUF222); Region:
                     DUF222; pfam02720"
                     /db_xref="CDD:308380"
     misc_feature    473594..473761
                     /locus_tag="Rv0393"
                     /note="HNH nucleases; HNH endonuclease signature which is
                     found in viral, prokaryotic, and eukaryotic proteins. The
                     alignment includes members of the large group of homing
                     endonucleases, yeast intron 1 protein, MutS, as well as
                     bacterial colicins, pyocins, and...; Region: HNHc;
                     cd00085"
                     /db_xref="CDD:238038"
     misc_feature    order(473669..473671,473675..473683,473687..473689,
                     473720..473725,473735..473740,473747..473749,
                     473759..473761)
                     /locus_tag="Rv0393"
                     /note="active site"
                     /db_xref="CDD:238038"
     gene            complement(474122..474841)
                     /locus_tag="Rv0394c"
                     /db_xref="GeneID:886435"
     CDS             complement(474122..474841)
                     /locus_tag="Rv0394c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214908.1"
                     /db_xref="GeneID:886435"
                     /translation="MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETT
                     TREICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDD
                     QKVEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVL
                     AALIQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLI
                     LPSGGSAPTGDHPTPHPSTSR"
     gene            474940..475344
                     /locus_tag="Rv0395"
                     /db_xref="GeneID:886425"
     CDS             474940..475344
                     /locus_tag="Rv0395"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214909.1"
                     /db_xref="GeneID:886425"
                     /translation="MDWMPLGDYETFRHWSGKPRAWGPQESGWRAWFGGKIVDGLCEV
                     LDEHLAVRRRGVPAAIGCVPWLSSEAVAETLLALSVFCVVIDKGTSFPSRLRNPDKGF
                     PNVALLRLRDMAPSEHGSRCSSARGRLCLSMS"
     gene            475350..475742
                     /locus_tag="Rv0396"
                     /db_xref="GeneID:886423"
     CDS             475350..475742
                     /locus_tag="Rv0396"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214910.1"
                     /db_xref="GeneID:886423"
                     /translation="MRALGWLREDRKPLLNAKLLVLGHLALNVYDPDNGYGEEVLDFE
                     PRTVWWGSANWTVRAGSHLEVGFACDDPTLVEEATAFVADVIAFSEPIDTTCAGPEPN
                     LVQVEFDDAAMAEAMEEMAEPDDDGEDW"
     gene            475816..476184
                     /locus_tag="Rv0397"
                     /db_xref="GeneID:886421"
     CDS             475816..476184
                     /locus_tag="Rv0397"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214911.1"
                     /db_xref="GeneID:886421"
                     /translation="MLATFWGWRAQQLPDGTVIWTLPGDQTYVTTPGSALLFPALCTP
                     TGDPPRPDPARADRRGQRTAMMPRRASTRAQNRAHYIAAERHRNHQARRIAHVVTQTA
                     TTAPETNGPPPDPDDDPPPF"
     gene            476394..476642
                     /locus_tag="Rv0397A"
                     /db_xref="GeneID:14515846"
     CDS             476394..476642
                     /locus_tag="Rv0397A"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_004837048.2"
                     /db_xref="GeneID:14515846"
                     /translation="MHALRLVGLAILTAIAPIAVLIGSSPAHADTDIGQPCSPEGAKL
                     WGNPGPIYCERTADGQLQWVSIPAWALCVAFCDRPGGP"
     gene            complement(476679..477320)
                     /locus_tag="Rv0398c"
                     /db_xref="GeneID:886419"
     CDS             complement(476679..477320)
                     /locus_tag="Rv0398c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214912.1"
                     /db_xref="GeneID:886419"
                     /translation="MGVIARVVGVAACGLSLAVLAAAPTAGAEPTGALPPMTSSGSGP
                     VIGDGDAALRQRISQQLFSFGDPTVQEVDGSDAAQFITAAAAVADRDVASVFLPLQRV
                     LGCQQNTAGSGAGFGARAYRRTDGQWGGAMLVVAKSTVSDVDALKACVKSGWRKATAG
                     TPTSMCNNGWTYPPFADTRRGEEGYFVLLAGTASDFCSAPNANYRTTASSWPG"
     gene            complement(477327..478556)
                     /gene="lpqK"
                     /locus_tag="Rv0399c"
                     /db_xref="GeneID:886416"
     CDS             complement(477327..478556)
                     /gene="lpqK"
                     /locus_tag="Rv0399c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein LpqK"
                     /protein_id="NP_214913.1"
                     /db_xref="GeneID:886416"
                     /translation="MPVLRRLGCSVLALGLLAGCAPPRTGPASSPTNNGAKADAVIRI
                     VRDFMTQAHLKAVLVRVTVAGKEVVTRAVGDSMTGVPATTAMHFRNGAVAISYVATLL
                     LKLVDEKKLRLDDKLSRWLPDFPHADRVTLGQLAQMTSGYPDYVLGNEAFDAELYANP
                     FRQWTTQELLDQISSRPLLYDPGTNWNYAHTNYLLLGLALEKAAGQDMPTLLQRKVLS
                     PLGLTATANSDTPAIPEPALHAFTSERRAALKIPAGVPFYEESTFWNPSWTITHGAIQ
                     TTTIYDMEATAVGIGSGRLLSADSYKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLG
                     IVISGHWLLQNPMFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQGNYRNQADILFRK
                     IGAEVAPNDAPPMPPGR"
     misc_feature    complement(477387..478436)
                     /gene="lpqK"
                     /locus_tag="Rv0399c"
                     /note="Beta-lactamase; Region: Beta-lactamase; pfam00144"
                     /db_xref="CDD:306621"
     gene            complement(478566..479753)
                     /gene="fadE7"
                     /locus_tag="Rv0400c"
                     /db_xref="GeneID:886427"
     CDS             complement(478566..479753)
                     /gene="fadE7"
                     /locus_tag="Rv0400c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase FadE7"
                     /protein_id="NP_214914.1"
                     /db_xref="GeneID:886427"
                     /translation="MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHV
                     AAWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRS
                     LVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARR
                     DGPDWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRA
                     SITSELVLDNVRLPADAMLPGATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYA
                     RQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNN
                     TREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLA
                     AFR"
     misc_feature    complement(478572..479729)
                     /gene="fadE7"
                     /locus_tag="Rv0400c"
                     /note="Glutaryl-CoA dehydrogenase; Region: GCD; cd01151"
                     /db_xref="CDD:173840"
     misc_feature    complement(order(478620..478622,478626..478628,
                     478647..478649,479229..479231,479235..479237,
                     479307..479312,479325..479330,479334..479336))
                     /gene="fadE7"
                     /locus_tag="Rv0400c"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173840"
     misc_feature    complement(order(478632..478637,478992..478994,
                     479001..479006,479025..479027,479307..479309))
                     /gene="fadE7"
                     /locus_tag="Rv0400c"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:173840"
     misc_feature    complement(478632..478634)
                     /gene="fadE7"
                     /locus_tag="Rv0400c"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173840"
     gene            479789..480160
                     /locus_tag="Rv0401"
                     /db_xref="GeneID:886438"
     CDS             479789..480160
                     /locus_tag="Rv0401"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214915.1"
                     /db_xref="GeneID:886438"
                     /translation="MRPRRALAGLAADVVAVLVFCAVGRRSHAEGLSVTGLAATAWPF
                     LTGTGIGWVLARGWRRPTALAPTGVIVWLCTIVVGMVLRKVSSAGVAASFVVVASAVT
                     AVLLLGWRAAVALMAPHRADG"
     misc_feature    479816..480127
                     /locus_tag="Rv0401"
                     /note="Protein of unknown function (DUF3054); Region:
                     DUF3054; pfam11255"
                     /db_xref="CDD:314242"
     gene            complement(480355..483231)
                     /gene="mmpL1"
                     /locus_tag="Rv0402c"
                     /db_xref="GeneID:886413"
     CDS             complement(480355..483231)
                     /gene="mmpL1"
                     /locus_tag="Rv0402c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane transport protein MmpL1"
                     /protein_id="NP_214916.1"
                     /db_xref="GeneID:886413"
                     /translation="MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQS
                     VARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLV
                     TKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQR
                     IVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAA
                     LIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQE
                     ARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVT
                     VMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIG
                     LLALPKYQTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDM
                     LILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVA
                     DLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFW
                     RPLRSFTYWERHCFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLA
                     QLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPE
                     AFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQ
                     AASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVAL
                     SLGSAFGLSVLIWQHILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKT
                     GMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMT
                     PALATLLGRWFWWPRRVDRLARQPQVLGPRRTTALSAERAALLQ"
     misc_feature    complement(480433..483210)
                     /gene="mmpL1"
                     /locus_tag="Rv0402c"
                     /note="Uncharacterized membrane protein YdfJ, MMPL/SSD
                     domain [Function unknown]; Region: YdfJ; COG2409"
                     /db_xref="CDD:225272"
     gene            complement(483228..483656)
                     /gene="mmpS1"
                     /locus_tag="Rv0403c"
                     /db_xref="GeneID:886411"
     CDS             complement(483228..483656)
                     /gene="mmpS1"
                     /locus_tag="Rv0403c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein MmpS1"
                     /protein_id="NP_214917.1"
                     /db_xref="GeneID:886411"
                     /translation="MFGVAKRFWIPMVIVIVVAVAAVTVSRLHSVFGSHQHAPDTGNL
                     DPIIAFYPKHVLYEVFGPPGTVASINYLDADAQPHEVVNAAVPWSFTIVTTLTAVVAN
                     VVARGDGASLGCRITVNEVIREERIVNAYHAHTSCLVKSA"
     misc_feature    complement(483234..483644)
                     /gene="mmpS1"
                     /locus_tag="Rv0403c"
                     /note="Mycobacterium membrane protein; Region:
                     Mycobact_memb; pfam05423"
                     /db_xref="CDD:283157"
     gene            483977..485734
                     /gene="fadD30"
                     /locus_tag="Rv0404"
                     /db_xref="GeneID:886409"
     CDS             483977..485734
                     /gene="fadD30"
                     /locus_tag="Rv0404"
                     /experiment="EXISTENCE:Gene expression[PMID:15042094]"
                     /note="fadD30, fatty-acid-AMP synthetase"
                     /codon_start=1
                     /transl_table=11
                     /product="long-chain-fatty-acid--AMP ligase FadD30"
                     /protein_id="NP_214918.1"
                     /db_xref="GeneID:886409"
                     /translation="MSVISTLRDRATTTPSDEAFVFMDYDTKTGDQIDRMTWSQLYSR
                     VTAVSAYLISYGRHADRRRTAAISAPQGLDYVAGFLGALCAGWTPVPLPEPLGSLRDK
                     RTGLAVLDCAADVVLTTSQAETRVRATIATHGASVTTPVIALDTLDEPSGDNCDLDSQ
                     LSDWSSYLQYTSGSTANPRGVVLSMRNVTENVDQIIRNYFRHEGGAPRLPSSVVSWLP
                     LYHDMGLMVGLFIPLFVGCPVILTSPEAFIRKPARWMQLLAKHQAPFSAAPNFAFDLA
                     VAKTSEEDMAGLDLGHVNTIINGAEQVQPNTITKFLRRFRPYNLMPAAVKPSYGMAEA
                     VVYLATTKAGSPPTSTEFDADSLARGHAELSTFETERATRLIRYHSDDKEPLLRIVDP
                     DSNIELGPGRIGEIWIHGKNVSTGYHNADDALNRDKFQASIREASAGTPRSPWLRTGD
                     LGFIVGDEFYIVGRMKDLIIQDGVNHYPDDIETTVKEFTGGRVAAFSVSDDGVEHLVI
                     AAEVRTEHGPDKVTIMDFSTIKRLVVSALSKLHGLHVTDFLLVPPGALPKTTSGKISR
                     AACAKQYGANKLQRVATFP"
     misc_feature    483977..485731
                     /gene="fadD30"
                     /locus_tag="Rv0404"
                     /note="acyl-CoA synthetase; Validated; Region: PRK05850"
                     /db_xref="CDD:235624"
     gene            485731..489939
                     /gene="pks6"
                     /locus_tag="Rv0405"
                     /db_xref="GeneID:886407"
     CDS             485731..489939
                     /gene="pks6"
                     /locus_tag="Rv0405"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00012"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00606"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane bound polyketide synthase"
                     /protein_id="NP_214919.1"
                     /db_xref="GeneID:886407"
                     /translation="MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSI
                     DVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGR
                     GSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFL
                     KDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVS
                     STDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVH
                     LACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEG
                     CGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARV
                     DPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGI
                     AGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSS
                     FGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGR
                     YVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGV
                     GKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGH
                     DQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDA
                     AMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAV
                     SAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQ
                     LVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQ
                     IVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW
                     LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAV
                     LGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYL
                     ITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPV
                     RNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDS
                     SDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLG
                     VALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI
                     FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMM
                     STSSEAIATEIHDWISGLVRGPHR"
     misc_feature    485734..485979
                     /gene="pks6"
                     /locus_tag="Rv0405"
                     /note="Acyl carrier protein [Lipid transport and
                     metabolism, Secondary metabolites biosynthesis, transport
                     and catabolism]; Region: AcpP; COG0236"
                     /db_xref="CDD:223314"
     misc_feature    486040..489018
                     /gene="pks6"
                     /locus_tag="Rv0405"
                     /note="Acyl transferase domain in polyketide synthase
                     (PKS) enzymes [Secondary metabolites biosynthesis,
                     transport and catabolism]; Region: PksD; COG3321"
                     /db_xref="CDD:225858"
     misc_feature    489229..489909
                     /gene="pks6"
                     /locus_tag="Rv0405"
                     /note="Thioesterase; Region: PKS_TE; smart00824"
                     /db_xref="CDD:214835"
     gene            complement(489887..490705)
                     /locus_tag="Rv0406c"
                     /db_xref="GeneID:886403"
     CDS             complement(489887..490705)
                     /locus_tag="Rv0406c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta lactamase-like protein"
                     /protein_id="NP_214920.1"
                     /db_xref="GeneID:886403"
                     /translation="MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLV
                     TDDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHS
                     TPVYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQP
                     LTAEAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAV
                     FSHSQQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR"
     misc_feature    complement(489968..490591)
                     /locus_tag="Rv0406c"
                     /note="uncharacterized subgroup which includes Bacillus
                     subtilis yflN; MBL-fold metallo hydrolase domain; Region:
                     yflN-like_MBL-fold; cd07721"
                     /db_xref="CDD:293807"
     misc_feature    complement(order(489971..489973,490112..490114,
                     490160..490165,490436..490441,490445..490447,
                     490451..490453))
                     /locus_tag="Rv0406c"
                     /note="putative active site [active]"
                     /db_xref="CDD:293807"
     misc_feature    complement(order(489971..489973,490112..490114,
                     490163..490165,490439..490441,490445..490447,
                     490451..490453))
                     /locus_tag="Rv0406c"
                     /note="putative metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:293807"
     misc_feature    complement(order(490112..490114,490163..490165,
                     490445..490447,490451..490453))
                     /locus_tag="Rv0406c"
                     /note="putative metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:293807"
     misc_feature    complement(order(489971..489973,490112..490114,
                     490439..490441))
                     /locus_tag="Rv0406c"
                     /note="putative metal binding site [ion binding]; other
                     site"
                     /db_xref="CDD:293807"
     gene            490783..491793
                     /gene="fgd1"
                     /locus_tag="Rv0407"
                     /gene_synonym="fgd"
                     /db_xref="GeneID:886418"
     CDS             490783..491793
                     /gene="fgd1"
                     /locus_tag="Rv0407"
                     /gene_synonym="fgd"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:17376702]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="F420-dependent glucose-6-phosphate
                     dehydrogenase"
                     /protein_id="NP_214921.1"
                     /db_xref="GeneID:886418"
                     /translation="MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPW
                     RHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVF
                     LGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGA
                     SIYDVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAA
                     DRSVDGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALP
                     IEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRR
                     LG"
     misc_feature    490789..491781
                     /gene="fgd1"
                     /locus_tag="Rv0407"
                     /gene_synonym="fgd"
                     /note="glucose-6-phosphate dehydrogenase (coenzyme-F420);
                     Region: F420_G6P_DH; TIGR03554"
                     /db_xref="CDD:213827"
     gene            491786..493858
                     /gene="pta"
                     /locus_tag="Rv0408"
                     /db_xref="GeneID:886401"
     CDS             491786..493858
                     /gene="pta"
                     /locus_tag="Rv0408"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to the phosphate acetyltransferase and
                     butyryltransferase family."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /protein_id="NP_214922.1"
                     /db_xref="GeneID:886401"
                     /translation="MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITR
                     LSAERDYILELLLAHTSAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAV
                     VVVGSDYTDVTSPTELSVNGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQ
                     RAHTAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVS
                     GDVALREREVMGVLAAGMTADHVLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSL
                     SCIVLNGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAASARGLVTATSQRKID
                     TALELMDRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRIL
                     KSAGRLLQRGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQL
                     RKAKGITVEHAREIMNDATYFGTMLVHNCHADGMVSGAAHTTAHTVRPALEIIKTVPG
                     ISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPRVAMLSY
                     STGDSGKGADVDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRA
                     TVLIFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITA
                     IQAQGVHE"
     misc_feature    491795..493843
                     /gene="pta"
                     /locus_tag="Rv0408"
                     /note="phosphate acetyltransferase; Reviewed; Region:
                     PRK05632"
                     /db_xref="CDD:235537"
     gene            493851..495008
                     /gene="ackA"
                     /locus_tag="Rv0409"
                     /db_xref="GeneID:886399"
     CDS             493851..495008
                     /gene="ackA"
                     /locus_tag="Rv0409"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00758"
                     /inference="protein motif:PROSITE:PS01075"
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="NP_214923.1"
                     /db_xref="GeneID:886399"
                     /translation="MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVA
                     DHAQALHRAFKMLAEDGIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSA
                     LAPLHNPPAVLGIKVARRLLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRR
                     YGFHGTSHQYVSERAAAFLGRPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLE
                     GLVMGTRSGDLDPGVISYLWRTARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIET
                     GDRSAQLAYEVFIHRLRKYLGAYLAVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLG
                     IALDQDRNLGPGHGARRISSDDSPIAVLVVPTNEELAIARDCLRVLGGRRA"
     misc_feature    493863..494999
                     /gene="ackA"
                     /locus_tag="Rv0409"
                     /note="acetate kinase A/propionate kinase 2; Reviewed;
                     Region: PRK00180"
                     /db_xref="CDD:234680"
     gene            complement(495062..497314)
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /db_xref="GeneID:886397"
     CDS             complement(495062..497314)
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /experiment="DESCRIPTION:Gene expression and protein
                     characterization[PMID:11496007]"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis[PMID:15186418]"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis[PMID:19528288]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00108"
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine-protein kinase PknG"
                     /protein_id="NP_214924.1"
                     /db_xref="GeneID:886397"
                     /translation="MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDED
                     NFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPES
                     KRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHG
                     GLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVE
                     HTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYND
                     LKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRT
                     LAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQL
                     TGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIV
                     TALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLME
                     VRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTF
                     PGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVR
                     TLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIR
                     ALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDM
                     ANKVRPTSTF"
     misc_feature    complement(496865..497281)
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="Protein kinase G rubredoxin domain; Region:
                     PknG_rubred; pfam16919"
                     /db_xref="CDD:319005"
     misc_feature    complement(496133..496867)
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="Catalytic domain of bacterial Serine/Threonine
                     kinases, PknB and similar proteins; Region:
                     STKc_PknB_like; cd14014"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(496616..496618,496667..496678,
                     496691..496693,496706..496708,496787..496792,
                     496865..496867))
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(496382..496393,496427..496429,
                     496436..496441,496466..496468,496472..496477,
                     496481..496483,496487..496489,496592..496594,
                     496598..496600,496610..496621,496682..496684,
                     496772..496774,496778..496780,496820..496822,
                     496826..496837,496841..496846))
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="active site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(496436..496441,496466..496468,
                     496472..496477,496481..496483,496598..496600,
                     496610..496621,496682..496684,496772..496774,
                     496778..496780,496820..496822,496826..496837,
                     496841..496846))
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(496382..496393,496427..496429,
                     496475..496477,496481..496483,496487..496489,
                     496592..496594,496598..496600,496832..496834))
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(order(496382..496405,496424..496441))
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270916"
     misc_feature    complement(495071..496090)
                     /gene="pknG"
                     /locus_tag="Rv0410c"
                     /note="Protein kinase G tetratricopeptide repeat; Region:
                     PknG_TPR; pfam16918"
                     /db_xref="CDD:319004"
     gene            complement(497314..498300)
                     /gene="glnH"
                     /locus_tag="Rv0411c"
                     /db_xref="GeneID:886393"
     CDS             complement(497314..498300)
                     /gene="glnH"
                     /locus_tag="Rv0411c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00013"
                     /inference="protein motif:PROSITE:PS01039"
                     /note="Belongs to the bacterial extracellular
                     solute-binding protein family 3"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-binding lipoprotein GlnH"
                     /protein_id="NP_214925.1"
                     /db_xref="GeneID:886393"
                     /translation="MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPT
                     PVGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDIGS
                     NLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVV
                     KTMSITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDLSGKRVCVARGTTSLRRIR
                     EIAPPPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPY
                     GVGINLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD"
     misc_feature    complement(497365..498048)
                     /gene="glnH"
                     /locus_tag="Rv0411c"
                     /note="Substrate binding domain of ABC glutamate
                     transporter; the type 2 periplasmic binding protein fold;
                     Region: PBP2_GluB; cd13690"
                     /db_xref="CDD:270408"
     misc_feature    complement(order(497473..497475,497551..497556,
                     497665..497670,497794..497796,497815..497817,
                     497860..497862,497995..497997,498004..498006))
                     /gene="glnH"
                     /locus_tag="Rv0411c"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270408"
     misc_feature    complement(order(497599..497601,497608..497610,
                     497962..497964,497977..497979))
                     /gene="glnH"
                     /locus_tag="Rv0411c"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:270408"
     gene            complement(498300..499619)
                     /locus_tag="Rv0412c"
                     /db_xref="GeneID:886415"
     CDS             complement(498300..499619)
                     /locus_tag="Rv0412c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214926.1"
                     /db_xref="GeneID:886415"
                     /translation="MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLA
                     ALGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAE
                     PGGVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRA
                     GNPVGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVV
                     FGAFAHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLK
                     TITNLAITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPD
                     LQGADQLLVRWRQANDRINSDISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMG
                     QSRTQLRHDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR"
     gene            499713..500366
                     /gene="mutT3"
                     /locus_tag="Rv0413"
                     /db_xref="GeneID:886405"
     CDS             499713..500366
                     /gene="mutT3"
                     /locus_tag="Rv0413"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="mutator protein MutT,
                     7,8-dihydro-8-oxoguanine-triphosphatase (8-oxo-dGTPase)
                     (dGTP pyrophosphohydrolase"
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="NP_214927.1"
                     /db_xref="GeneID:886405"
                     /translation="MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRP
                     DGTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQTAVRESSEEAGLSAERLEVRAT
                     VVTAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAAS
                     WQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL"
     misc_feature    499809..500165
                     /gene="mutT3"
                     /locus_tag="Rv0413"
                     /note="Nudix hydrolase is a superfamily of enzymes found
                     in all three kingdoms of life, and it catalyzes the
                     hydrolysis of NUcleoside DIphosphates linked to other
                     moieties, X. Enzymes belonging to this superfamily require
                     a divalent cation, such as Mg2+ or Mn2+...; Region:
                     Nudix_Hydrolase; cl00447"
                     /db_xref="CDD:320976"
     misc_feature    order(499920..499928,499956..499982)
                     /gene="mutT3"
                     /locus_tag="Rv0413"
                     /note="nudix motif; other site"
                     /db_xref="CDD:239217"
     gene            complement(500350..501018)
                     /gene="thiE"
                     /locus_tag="Rv0414c"
                     /db_xref="GeneID:886391"
     CDS             complement(500350..501018)
                     /gene="thiE"
                     /locus_tag="Rv0414c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="thiamine-phosphate pyrophosphorylase, TMP
                     pyrophosphorylase (TMP-PPASE) (thiamine-phosphate
                     synthase)"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine-phosphate synthase"
                     /protein_id="NP_214928.1"
                     /db_xref="GeneID:886391"
                     /translation="MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDK
                     GSPGELRFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQRDL
                     PVNVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKPGRAAPGLGLV
                     RVAAELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSAL
                     TAAN"
     misc_feature    complement(500353..501009)
                     /gene="thiE"
                     /locus_tag="Rv0414c"
                     /note="thiamine-phosphate pyrophosphorylase; Reviewed;
                     Region: thiE; PRK00043"
                     /db_xref="CDD:234590"
     gene            501148..502170
                     /gene="thiO"
                     /locus_tag="Rv0415"
                     /db_xref="GeneID:886390"
     CDS             501148..502170
                     /gene="thiO"
                     /locus_tag="Rv0415"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21030493]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine biosynthesis oxidoreductase ThiO"
                     /protein_id="NP_214929.1"
                     /db_xref="GeneID:886390"
                     /translation="MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSDERGAS
                     WVAGGMLAPHSEGWPGEERLLRLGLQSLRLWREGSFLDGLGPQLVTAHESLVVAVDRA
                     DVADLRTVADWLSAQGHPVIWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDALC
                     RDCERLGVRWSSQVSSLSDVDAHTVVIANGIDAPALWPGLPIRPVKGEVLRLRWRPGC
                     MPLPQRVIRARVRGRQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLP
                     ALGEYELAECEAGLRPMTPDNLPLVQRLDSRTLVAAGHGRSGFLLAPWTAEQIVSELV
                     SVGAAS"
     misc_feature    501217..502158
                     /gene="thiO"
                     /locus_tag="Rv0415"
                     /note="glycine oxidase ThiO; Region: thiamin_ThiO;
                     TIGR02352"
                     /db_xref="CDD:274092"
     gene            502167..502373
                     /gene="thiS"
                     /locus_tag="Rv0416"
                     /db_xref="GeneID:886395"
     CDS             502167..502373
                     /gene="thiS"
                     /locus_tag="Rv0416"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfur carrier protein ThiS"
                     /protein_id="NP_214930.1"
                     /db_xref="GeneID:886395"
                     /translation="MIVVVNEQQVEVDEQTTIAALLDSLGFGDRGIAVALNFSVLPRS
                     DWATKICELRKPVRLEVVTAVQGG"
     misc_feature    502203..502370
                     /gene="thiS"
                     /locus_tag="Rv0416"
                     /note="The TGS domain, named after the ThrRS, GTPase, and
                     SpoT/RelA proteins where it occurs, is structurally
                     similar to ubiquitin. TGS is a small domain of about 50
                     amino acid residues with a predominantly beta-sheet
                     structure. There is no direct information...; Region: TGS;
                     cl25424"
                     /db_xref="CDD:330245"
     gene            502366..503124
                     /gene="thiG"
                     /locus_tag="Rv0417"
                     /db_xref="GeneID:886396"
     CDS             502366..503124
                     /gene="thiG"
                     /locus_tag="Rv0417"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="thiamin biosynthesis protein ThiG"
                     /codon_start=1
                     /transl_table=11
                     /product="thiazole synthase"
                     /protein_id="NP_214931.1"
                     /db_xref="GeneID:886396"
                     /translation="MAESKLVIGDRSFASRLIMGTGGATNLAVLEQALIASGTELTTV
                     AIRRVDADGGTGLLDLLNRLGITPLPNTAGSRSAAEAVLTAQLAREALNTNWVKLEVI
                     ADERTLWPDAVELVRAAEQLVDDGFVVLPYTTDDPVLARRLEDTGCAAVMPLGSPIGT
                     GLGIANPHNIEMIVAGARVPVVLDAGIGTASDAALAMELGCDAVLLASAVTRAADPPA
                     MAAAMAAAVTAGYLARCAGRIPKRFWAQASSPAR"
     misc_feature    502378..503115
                     /gene="thiG"
                     /locus_tag="Rv0417"
                     /note="thiazole synthase; Reviewed; Region: thiG;
                     PRK00208"
                     /db_xref="CDD:234687"
     gene            503496..504998
                     /gene="lpqL"
                     /locus_tag="Rv0418"
                     /db_xref="GeneID:886381"
     CDS             503496..504998
                     /gene="lpqL"
                     /locus_tag="Rv0418"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00013"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein aminopeptidase LpqL"
                     /protein_id="NP_214932.1"
                     /db_xref="GeneID:886381"
                     /translation="MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEF
                     AVALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQT
                     PEFSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDY
                     DRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIP
                     VVSVTKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVP
                     EGPGINDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDA
                     LKGIALYLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAG
                     KTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQK
                     TDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP"
     misc_feature    503646..504941
                     /gene="lpqL"
                     /locus_tag="Rv0418"
                     /note="M28 Zn-peptidase Streptomyces griseus
                     Aminopeptidase and similar proteins; Region:
                     M28_SGAP_like; cd03876"
                     /db_xref="CDD:193498"
     misc_feature    503865..504224
                     /gene="lpqL"
                     /locus_tag="Rv0418"
                     /note="PA_SaNapH_like: Protease-associated domain
                     containing proteins like Streptomyces anulatus
                     N-acetylpuromycin N-acetylhydrolase (SaNapH).This group
                     contains various PA domain-containing proteins similar
                     SaNapH. Proteins in this group belong to the...; Region:
                     PA_SaNapH_like; cd04816"
                     /db_xref="CDD:240120"
     misc_feature    504102..504110
                     /gene="lpqL"
                     /locus_tag="Rv0418"
                     /note="PA/protease or protease-like domain interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:240120"
     misc_feature    order(504306..504308,504342..504347,504441..504446,
                     504528..504533,504693..504695,504702..504707,
                     504753..504755,504834..504839)
                     /gene="lpqL"
                     /locus_tag="Rv0418"
                     /note="active site"
                     /db_xref="CDD:193498"
     misc_feature    order(504306..504308,504342..504344,504444..504446,
                     504528..504530,504837..504839)
                     /gene="lpqL"
                     /locus_tag="Rv0418"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:193498"
     gene            505086..506582
                     /gene="lpqM"
                     /locus_tag="Rv0419"
                     /db_xref="GeneID:886388"
     CDS             505086..506582
                     /gene="lpqM"
                     /locus_tag="Rv0419"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00013"
                     /inference="protein motif:PROSITE:PS00142"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein peptidase LpqM"
                     /protein_id="NP_214933.1"
                     /db_xref="GeneID:886388"
                     /translation="MHGRGRYRPLVRCVRPRRVAASVRTPIACLAAVVVIAGCTTVVD
                     GRALSILNDPFRVGGLPATNGPSGARPDAPAASGTVINTNNGAIDKLSLLSVNDIEDY
                     WMAVYSESLKGTFRPVGKLVSYDSNDPSSPIVCHIDTYQLVNAFFSSRCNLIAWDRGV
                     FMAVAQEYFGDMSVNGVLAHEFGHALQVMANLVTRKDPTIVREQQADCFAGVYLWWVA
                     EGKSTRFTLSTADGLDHVLAGIITTRDPVMEADAENDDEHGSALDRVSAFQLGFINGT
                     PACAAIDEDEVERRRGDLPTALRVDASGNPETGEVGINEETLSTLMELMGKIFSPKNP
                     PTLSYQPAGCPDAKPSPPAAYCPATNTIVVDLPALARMGKVASAAEHSLPQGDDTSLS
                     IVMSRYALAVQHERGLPMQSPWTALRTACLTGVAHRKMAVPIDLPSGQQLVLTAGDLD
                     EAVSGLLTNRMVASDADGVSVPAGFTRIAAFRAGVGGDMDACYARYPG"
     misc_feature    505086..505949
                     /gene="lpqM"
                     /locus_tag="Rv0419"
                     /note="Predicted metalloprotease [General function
                     prediction only]; Region: YpfJ; COG2321"
                     /db_xref="CDD:225203"
     gene            complement(506561..506971)
                     /locus_tag="Rv0420c"
                     /db_xref="GeneID:886383"
     CDS             complement(506561..506971)
                     /locus_tag="Rv0420c"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214934.1"
                     /db_xref="GeneID:886383"
                     /translation="MRLHDASAAAPESRMHIARHGEAVNRRQMFIGITGLLLAVIGLM
                     ALWFPVYLDQYDAYGIKVTCGSGWRSNLTQALYADGNDNTQALVTRCDTALLVRRAWA
                     IPSVALGWLLVTGFLVMWVHNDQHQGQSYPGYRA"
     gene            complement(507132..507761)
                     /locus_tag="Rv0421c"
                     /db_xref="GeneID:886377"
     CDS             complement(507132..507761)
                     /locus_tag="Rv0421c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214935.1"
                     /db_xref="GeneID:886377"
                     /translation="MNLDQIAGVAHQPAGPPHGVVVLTHGAGGSRESTLLQQVCAEWT
                     RRGWLAVRYNLPYRRRRPTGPPSGSGSGDRAGIVEAIQLCRGLAEGPLIAGGHSYGGR
                     QTSMVVAAGQAPVDVLTLFSYPVHPPGKPERVRTEHLPGIAVPTVFTHGTADPFGTLA
                     QVRSAAAMVSAPTEVVEITGARHDLGSKTLDVARLAVDAALRLSAGQIA"
     misc_feature    complement(507135..507740)
                     /locus_tag="Rv0421c"
                     /note="Predicted hydrolase of the alpha/beta-hydrolase
                     fold [General function prediction only]; Region: COG3571"
                     /db_xref="CDD:226101"
     gene            complement(507758..508555)
                     /gene="thiD"
                     /locus_tag="Rv0422c"
                     /db_xref="GeneID:886375"
     CDS             complement(507758..508555)
                     /gene="thiD"
                     /locus_tag="Rv0422c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="phosphomethylpyrimidine kinase ThiD, HMP-phosphate
                     kinase (HMP-P kinase)"
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylpyrimidine/phosphomethylpyrimidine
                     kinase"
                     /protein_id="NP_214936.1"
                     /db_xref="GeneID:886375"
                     /translation="MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQ
                     NTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVP
                     LVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRA
                     AAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLAT
                     AIAAALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS"
     misc_feature    complement(507761..508555)
                     /gene="thiD"
                     /locus_tag="Rv0422c"
                     /note="bifunctional hydroxy-methylpyrimidine kinase/
                     hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region:
                     PRK06427"
                     /db_xref="CDD:180561"
     misc_feature    complement(order(508355..508360,508370..508372,
                     508379..508381,508388..508393,508397..508399,
                     508403..508408,508421..508435,508442..508444,
                     508448..508465,508472..508474,508481..508486,
                     508493..508495))
                     /gene="thiD"
                     /locus_tag="Rv0422c"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238574"
     misc_feature    complement(order(507914..507916,508316..508318,
                     508424..508426,508487..508489))
                     /gene="thiD"
                     /locus_tag="Rv0422c"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238574"
     misc_feature    complement(order(507917..507919,507923..507925,
                     508028..508030,508127..508129,508238..508240))
                     /gene="thiD"
                     /locus_tag="Rv0422c"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:238574"
     gene            complement(508582..510225)
                     /gene="thiC"
                     /locus_tag="Rv0423c"
                     /db_xref="GeneID:886379"
     CDS             complement(508582..510225)
                     /gene="thiC"
                     /locus_tag="Rv0423c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="thiamine biosynthesis protein ThiC"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomethylpyrimidine synthase"
                     /protein_id="NP_214937.1"
                     /db_xref="GeneID:886379"
                     /translation="MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLST
                     GDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAAR
                     EDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEV
                     DKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELT
                     WEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRE
                     SFLYTNFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHG
                     AQVMIEGPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAII
                     AQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTA
                     RFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDVREYA
                     AEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ"
     misc_feature    complement(508591..510207)
                     /gene="thiC"
                     /locus_tag="Rv0423c"
                     /note="thiamine biosynthesis protein ThiC; Provisional;
                     Region: PRK09284"
                     /db_xref="CDD:236451"
     gene            complement(510377..510652)
                     /locus_tag="Rv0424c"
                     /db_xref="GeneID:886374"
     CDS             complement(510377..510652)
                     /locus_tag="Rv0424c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214938.1"
                     /db_xref="GeneID:886374"
                     /translation="MAEKNTRRATSQREAVAKIREAETIVMNLPICGQVKIPRPEHLA
                     YYGGLAALAALELIDWPVALVIATGHILANNHHNRVLEELGEAMEEA"
     gene            complement(510702..515321)
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /db_xref="GeneID:886373"
     CDS             complement(510702..515321)
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal cation transporting ATPase H"
                     /protein_id="NP_214939.1"
                     /db_xref="GeneID:886373"
                     /translation="MPVRAVATGFRATATLTGASITAATAVSATLAKTGVGTGMKVAI
                     IPLRAGAKALSGELSRETLGRNCWRGERRAWIEVRGLRSGGDDELGRVVLNAIQAHPG
                     VGSASLNYPLSRVVVAIDDPDTSLRELCRIVDDAEKAERHRHPDQAADQLAQSPGSLP
                     GDGVLLAVRAVTVAATAAGLGLALGGRALRWPRFPLVIEAAVAAVDHQPLLRRLLEDR
                     IGTEATATVLELAMAAAHTVTLSPAALSVDLTIQALKAAECRAGARAWRRHEPQLALH
                     ADEPADQPQSLWPRPARSTQPVQRSVARFALIQALSAVLVGAGTRDADMAATATLVAT
                     PKASRTTPEAFAAALGQGLADQHAVLPLRPESLRRLDRVDAIVIDPRVLCTDDLRVAR
                     IRGCGADELSTAWNRAQLVLTESGLRPGWHRVPGVSASGSDSAVEALFRPMHDRLASA
                     VVAEAHRTGADLVSVDVDALGELRPVFDDIRPLDDGASGSLDEALARAVAELRQAGRT
                     VAVLSSVGKQALSAADVALGVLPPPGAGAPPWYADVLLPDLGAAWRVLHAIPAARAAR
                     QRGNEISGGASALGALLMLPGVRGLGPGPVTTGAAAGLLSGYLLARKVVDAQAPRPAP
                     AHEWHAMSVEQVRKALPSPDEQAPAKAPPSPYPARALAGGLHTAKRGAQITQAPLNAL
                     WQLTKAMRAELSDPLTPMLALGAMASAVLGSPVDAVMVGSVLTGNSILAASQRLRAES
                     RLNRLLAQQIPPARKVLAGADDQPRYIEVRAEELRPGDIIEVRTHEVVPADARVIEEV
                     DVEVDESALTGESLSVTKQVEPTPGVDLIERRCMLYAGTTVVSGTAVAVVTAVGPDTQ
                     ERRAAELVSGDLSSVGLQHQLSRLTNQAWPVSMTGGALVTGLGLLRRRGLRQAVASGI
                     AVTVAAVPEGMPLVATLAQQASARRLSHFGALVRIPRSVEALGRVDMVCFDKTGTLSE
                     NRLRVAQVRPVAGHSREEVLRCAAHAAPASNGPQVHATDVAIVQAAAAAAASGTDGAE
                     PGAAEPAAHLPFRSGRSFSASVSGTELTVKGAPEVVLAACEGIGSSMDDAVAELAANG
                     LRVIAVAHRQLTAQQAQSVVDDPDEIARLCRDELSLVGFLGLSDTPRAQAAALLADLH
                     EHDLDIRLITGDHPITAAAIAEELGMQVSPEQVISGAEWDALSRKDQERAVAERVIFA
                     RMTPENKVQIVQTLEHSGRVCAMVGDGSNDAAAIRAATVGIGVVAHGSDPARVAADLV
                     LVDGRIESLLPAILEGRQLWQRVQAAVSVLLGGNAGEVAFAIIGSAITGTSPLNTRQL
                     LLVNMLTDALPAAALAVSKPSDPVTPATRGPDQRELWRAVGIRGATTAAAATVAWVMA
                     GFTGLPRRASTVALVALVAAQLGQTLVDSHAWLVVLTALGSLAALATLISIPVVSQLL
                     GCTPLDPLGWAQATAAATAATVAVAVLNRVLTGRDKSGQPNPQPPETDALSRDASPGA
                     PPGPRRRRRATARRKAPVKAPSATRQTTKPKGPPAHRSSSTYPRR"
     misc_feature    complement(511308..513395)
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /note="uncharacterized subfamily of P-type ATPase
                     transporters; Region: P-type_ATPase; cd07539"
                     /db_xref="CDD:319840"
     misc_feature    complement(order(511623..511625,511632..511634,
                     511689..511691,511698..511700,511707..511709,
                     511848..511856,512046..512048,512136..512144,
                     512196..512198,512421..512429))
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319840"
     misc_feature    complement(512409..512429)
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /note="P-type ATPase signature motif; other site"
                     /db_xref="CDD:319840"
     misc_feature    complement(512427..512429)
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /note="phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:319840"
     misc_feature    complement(order(511338..511343,511350..511352,
                     511425..511430,511434..511439,511449..511451))
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /note="putative cation binding site [ion binding]; other
                     site"
                     /db_xref="CDD:319840"
     misc_feature    complement(510981..511388)
                     /gene="ctpH"
                     /locus_tag="Rv0425c"
                     /note="Cation transporting ATPase, C-terminus; Region:
                     Cation_ATPase_C; pfam00689"
                     /db_xref="CDD:307026"
     gene            complement(515373..515816)
                     /locus_tag="Rv0426c"
                     /db_xref="GeneID:886387"
     CDS             complement(515373..515816)
                     /locus_tag="Rv0426c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214940.1"
                     /db_xref="GeneID:886387"
                     /translation="MSVVGGTVRTVGRTVSGAATATTAAAGAVGGAAVSGIVGGVTGA
                     AKGIQKGLSSGSKSTAAAALAIGAIGVAGLVDWPILLAVGGGALLLRKLNRTPEVAAP
                     PVKAKLAPVPDKPAAAKEAPAKASKTTARKTSGRRAGTAELRSTN"
     gene            complement(516017..516892)
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /db_xref="GeneID:886370"
     CDS             complement(516017..516892)
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="exonuclease III (EXO III) (AP endonuclease VI)
                     Belongs to the AP/EXOA family of DNA repair enzymes."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III protein XthA"
                     /protein_id="NP_214941.1"
                     /db_xref="GeneID:886370"
                     /translation="MPDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDW
                     LGRADVDVLAMQETKCPDGQFPALPLFELGYDVAHVGFDQWNGVAIASRVGLDDVRVG
                     FDGQPSWSGKPEVAATTEARALGATCGGIRVWSLYVPNGRALDDPHYTYKLDWLAALR
                     DTAEGWLRDDPAAPIALMGDWNIAPTDDDVWSTEFFAGCTHVSEPERKAFNAIVDAQF
                     TDVVRPFTPGPGVYTYWDYTQLRFPKKQGMRIDFILGSPALAARVMDAQIVREERKGK
                     APSDHAPVLVDLHAG"
     misc_feature    complement(516029..516823)
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="Escherichia coli exonuclease III (ExoIII) and
                     Neisseria meningitides NExo-like subfamily of the ExoIII
                     family purinic/apyrimidinic (AP) endonucleases; Region:
                     ExoIII-like_AP-endo; cd09086"
                     /db_xref="CDD:197320"
     misc_feature    complement(order(516050..516052,516347..516349,
                     516353..516355,516473..516475,516482..516484,
                     516722..516724,516803..516805))
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="putative phosphate binding site [ion binding];
                     other site"
                     /db_xref="CDD:197320"
     misc_feature    complement(order(516050..516055,516140..516142,
                     516347..516349,516353..516355,516482..516484,
                     516722..516724,516803..516805))
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197320"
     misc_feature    complement(order(516050..516052,516059..516064,
                     516140..516145,516149..516151,516179..516184,
                     516191..516193,516347..516349,516353..516355,
                     516449..516451,516467..516469,516473..516475,
                     516482..516484,516641..516646,516722..516724,
                     516782..516790,516794..516799))
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="active site"
                     /db_xref="CDD:197320"
     misc_feature    complement(order(516050..516055,516722..516724,
                     516797..516799))
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="metal binding site A [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:197320"
     misc_feature    complement(order(516059..516064,516179..516184,
                     516449..516451,516467..516469,516473..516475,
                     516482..516484,516641..516646,516782..516790,
                     516794..516799))
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:197320"
     misc_feature    complement(order(516050..516052,516143..516145,
                     516149..516151,516191..516193,516347..516349,
                     516353..516355,516473..516475,516482..516484))
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="putative AP binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:197320"
     misc_feature    complement(order(516050..516052,516347..516349,
                     516353..516355,516482..516484))
                     /gene="xthA"
                     /locus_tag="Rv0427c"
                     /gene_synonym="xth"
                     /note="putative metal binding site B [ion binding]; other
                     site"
                     /db_xref="CDD:197320"
     gene            complement(516895..517803)
                     /locus_tag="Rv0428c"
                     /db_xref="GeneID:886368"
     CDS             complement(516895..517803)
                     /locus_tag="Rv0428c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="GCN5-like N-acetyltransferase"
                     /protein_id="NP_214942.1"
                     /db_xref="GeneID:886368"
                     /translation="MVSWPGLGTRVTVRYRRPAGSMPPLTDAVGRLLAVDPTVRVQTK
                     TGTIVEFSPVDVVALRVLTDAPVRTAAIRALEHAAAAAWPGVERTWLDGWLLRAGHGA
                     VLAANSAVPLDISAHTNTITEISAWYASRDLQPWLAVPDRLLPLPADLAGERREQVLV
                     RDVSTGEPDRSVTLLDHPDDTWLRLYHQRLPLDMATPVIDGELAFGSYLGVAVARAAV
                     TDAPDGTRWVGLSAMRAADEQSATGSAGRQLWEALLGWGAGRGATRGYVRVHDTATSV
                     LAESLGFRLHHHCRYLPAQSVGWDTF"
     gene            complement(517803..518396)
                     /gene="def"
                     /locus_tag="Rv0429c"
                     /db_xref="GeneID:886366"
     CDS             complement(517803..518396)
                     /gene="def"
                     /locus_tag="Rv0429c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Cofactor: binds 1 zinc ion."
                     /codon_start=1
                     /transl_table=11
                     /product="polypeptide deformylase"
                     /protein_id="NP_214943.1"
                     /db_xref="GeneID:886366"
                     /translation="MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTM
                     DAANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTD
                     DEGCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLD
                     RLIGRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH"
     misc_feature    complement(517863..518396)
                     /gene="def"
                     /locus_tag="Rv0429c"
                     /note="peptide deformylase; Reviewed; Region: def;
                     PRK00150"
                     /db_xref="CDD:234668"
     misc_feature    complement(order(517941..517943,517950..517955,
                     518076..518084,518229..518231,518244..518252))
                     /gene="def"
                     /locus_tag="Rv0429c"
                     /note="active site"
                     /db_xref="CDD:238271"
     misc_feature    complement(order(517950..517952,518076..518078,
                     518229..518231,518244..518246))
                     /gene="def"
                     /locus_tag="Rv0429c"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:238271"
     misc_feature    complement(order(517941..517943,517953..517955,
                     518079..518081))
                     /gene="def"
                     /locus_tag="Rv0429c"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238271"
     gene            518733..519041
                     /locus_tag="Rv0430"
                     /db_xref="GeneID:886364"
     CDS             518733..519041
                     /locus_tag="Rv0430"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214944.1"
                     /db_xref="GeneID:886364"
                     /translation="MDSAMARAIRSGDDAEVADGLTRREHDILAFERQWWKFAGVKEE
                     AIKELFSMSATRYYQVLNALVDRPEALAADPMLVKRLRRLRASRQKARAARRLGFEVT
                     "
     misc_feature    518790..519011
                     /locus_tag="Rv0430"
                     /note="Protein of unknown function (DUF3263); Region:
                     DUF3263; pfam11662"
                     /db_xref="CDD:314518"
     gene            519073..519567
                     /locus_tag="Rv0431"
                     /db_xref="GeneID:886362"
     CDS             519073..519567
                     /locus_tag="Rv0431"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="tuberculin-like peptide"
                     /protein_id="NP_214945.1"
                     /db_xref="GeneID:886362"
                     /translation="MLVTVGSMNERVPDSSGLPLRAMVMVLLFLGVVFLLLVWQALGS
                     SPNSEDDSSAISTMTTTTAAPTSTSVKPAAPRAEVRVYNISGTEGAAARTADRLKAAG
                     FTVTDVGNLSLPDVAATTVYYTEVEGERATADAVGRTLGAAVELRLPELSDQPPGVIV
                     VVTG"
     misc_feature    519307..519564
                     /locus_tag="Rv0431"
                     /note="LytR cell envelope-related transcriptional
                     attenuator; Region: LytR_C; pfam13399"
                     /db_xref="CDD:315962"
     gene            519600..520322
                     /gene="sodC"
                     /locus_tag="Rv0432"
                     /db_xref="GeneID:886358"
     CDS             519600..520322
                     /gene="sodC"
                     /locus_tag="Rv0432"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:15155722]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00013"
                     /note="Cu-Zn"
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="NP_214946.1"
                     /db_xref="GeneID:886358"
                     /translation="MPKPADHRNHAAVSTSVLSALFLGAGAALLSACSSPQHASTVPG
                     TTPSIWTGSPAPSGLSGHDEESPGAQSLTSTLTAPDGTKVATAKFEFANGYATVTIAT
                     TGVGKLTPGFHGLHIHQVGKCEPNSVAPTGGAPGNFLSAGGHYHVPGHTGTPASGDLA
                     SLQVRGDGSAMLVTTTDAFTMDDLLSGAKTAIIIHAGADNFANIPPERYVQVNGTPGP
                     DETTLTTGDAGKRVACGVIGSG"
     misc_feature    519654..520313
                     /gene="sodC"
                     /locus_tag="Rv0432"
                     /note="Cu/Zn superoxide dismutase [Inorganic ion transport
                     and metabolism]; Region: SodC; COG2032"
                     /db_xref="CDD:224943"
     misc_feature    order(519816..519818,519822..519824,519855..519857,
                     519861..519863,519957..519965,520200..520205)
                     /gene="sodC"
                     /locus_tag="Rv0432"
                     /note="E-class dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238186"
     misc_feature    order(519888..519890,520086..520088)
                     /gene="sodC"
                     /locus_tag="Rv0432"
                     /note="P-class dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238186"
     misc_feature    order(519945..519947,519951..519953,520029..520031,
                     520062..520064,520071..520073,520221..520223)
                     /gene="sodC"
                     /locus_tag="Rv0432"
                     /note="active site"
                     /db_xref="CDD:238186"
     misc_feature    order(519945..519947,519951..519953,520029..520031,
                     520221..520223)
                     /gene="sodC"
                     /locus_tag="Rv0432"
                     /note="Cu2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238186"
     gene            520324..521454
                     /locus_tag="Rv0433"
                     /db_xref="GeneID:886356"
     CDS             520324..521454
                     /locus_tag="Rv0433"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylate-amine ligase"
                     /protein_id="NP_214947.1"
                     /db_xref="GeneID:886356"
                     /translation="MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVI
                     AEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGT
                     HPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNY
                     YPHLLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTG
                     IIDHMDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGET
                     LPTMPPWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCAD
                     ELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI"
     misc_feature    520348..521448
                     /locus_tag="Rv0433"
                     /note="carboxylate-amine ligase; Provisional; Region:
                     PRK13517"
                     /db_xref="CDD:237408"
     gene            521514..522167
                     /locus_tag="Rv0434"
                     /db_xref="GeneID:886360"
     CDS             521514..522167
                     /locus_tag="Rv0434"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214948.1"
                     /db_xref="GeneID:886360"
                     /translation="MADFAPVELAMFPLESAPLPDEDLPLHIFEPRYAALVRDCMDTA
                     DPRFGVVLISRGREVGGGDTRCDVGTLARITECADAGSGRYMLRCRVGERIRVCDWLP
                     DDPYPRAKVRFWPDQPGHPVTAAQLLEVEDRVVALFERIAAARGVRLPAREVVLGYPV
                     VDPADTGQRLYALACRVPMGPADRYAVLATPSAADRLVRLGDALDSVAAMVEFELST"
     misc_feature    521514..522164
                     /locus_tag="Rv0434"
                     /note="Uncharacterized protein, LON-like domain,
                     ASCH/PUA-like superfamily [Function unknown]; Region: LON;
                     COG2802"
                     /db_xref="CDD:225362"
     gene            complement(522347..524533)
                     /locus_tag="Rv0435c"
                     /db_xref="GeneID:886352"
     CDS             complement(522347..524533)
                     /locus_tag="Rv0435c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00674"
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase"
                     /protein_id="NP_214949.1"
                     /db_xref="GeneID:886352"
                     /translation="MTHPDPARQLTLTARLNTSAVDSRRGVVRLHPNAIAALGIREWD
                     AVSLTGSRTTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGARSVT
                     LSGSTLATQSVPPVTLRQALLGKVMTVGDAVSLLPRDLGPGTSTSAASRALAAAVGIS
                     WTSELLTVTGVDPDGPVSVQPNSLVTWGAGVPAAMGTSTAGQVSISSPEIQIEELKGA
                     QPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCDGRRLVTL
                     DGPEIGALAAGDRVKAVASAVQAVRHEGGVLLITDADALLPAAAEPVASLILSELRTA
                     VATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTGDL
                     NLDEIASRTPGFVVADLAALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSR
                     SASDEVTVGDVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPG
                     CGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDEL
                     DALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRL
                     ERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALT
                     AMRRSIDAANVTAADLATARETVRASLDPLQVASLRKFGTKGDLRS"
     misc_feature    complement(522470..524470)
                     /locus_tag="Rv0435c"
                     /note="TIP49 C-terminus; Region: TIP49; cl27568"
                     /db_xref="CDD:332389"
     gene            complement(524530..525390)
                     /gene="pssA"
                     /locus_tag="Rv0436c"
                     /db_xref="GeneID:886385"
     CDS             complement(524530..525390)
                     /gene="pssA"
                     /locus_tag="Rv0436c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /inference="protein motif:PROSITE:PS00379"
                     /note="PS synthase (phosphatidylserine synthase). Belongs
                     to the CDP-alcohol phosphatidyltransferase class-I
                     family."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--serine
                     O-phosphatidyltransferase"
                     /protein_id="NP_214950.1"
                     /db_xref="GeneID:886385"
                     /translation="MIGKPRGRRGVNLQILPSAMTVLSICAGLTAIKFALEHQPKAAM
                     ALIAAAAILDGLDGRVARILDAQSRMGAEIDSLADAVNFGVTPALVLYVSMLSKWPVG
                     WVVVLLYAVCVVLRLARYNALQDDGTQPAYAHEFFVGMPAPAGAVSMIGLLALKMQFG
                     EGWWTSGWFLSFWVTGTSILLVSGIPMKKMHAVSVPPNYAAALLAVLAICAAAAVLAP
                     YLLIWVIIIAYMCHIPFAVRSQRWLAQHPEVWDDKPKQRRAVRRASRRAHPYRPSMAR
                     LGLRKPGRRL"
     misc_feature    complement(524677..525375)
                     /gene="pssA"
                     /locus_tag="Rv0436c"
                     /note="Phosphatidylserine synthase [Lipid transport and
                     metabolism]; Region: PssA; COG1183"
                     /db_xref="CDD:224104"
     gene            complement(525387..526082)
                     /gene="psd"
                     /locus_tag="Rv0437c"
                     /db_xref="GeneID:886350"
     CDS             complement(525387..526082)
                     /gene="psd"
                     /locus_tag="Rv0437c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidylserine decarboxylase"
                     /protein_id="NP_214951.1"
                     /db_xref="GeneID:886350"
                     /translation="MARRPRPDGPQHLLALVRSAVPPVHPAGRPFIAAGLAIAAVGHR
                     YRWLRGTGLLAAAACAGFFRHPQRVPPTRPAAIVAPADGVICAIDSAAPPAELSMGDT
                     PLPRVSIFLSILDAHVQRAPVSGEVIAVQHRPGRFGSADLPEASDDNERTSVRIRMPN
                     GAEVVAVQIAGLVARRIVCDAHVGDKLAIGDTYGLIRFGSRLDTYLPAGAEPIVNVGQ
                     RAVAGETVLAECR"
     misc_feature    complement(525396..526016)
                     /gene="psd"
                     /locus_tag="Rv0437c"
                     /note="phosphatidylserine decarboxylase; Provisional;
                     Region: PRK05305"
                     /db_xref="CDD:235400"
     gene            complement(526143..527360)
                     /gene="moeA2"
                     /locus_tag="Rv0438c"
                     /gene_synonym="moeA3"
                     /db_xref="GeneID:886348"
     CDS             complement(526143..527360)
                     /gene="moeA2"
                     /locus_tag="Rv0438c"
                     /gene_synonym="moeA3"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /experiment="EXISTENCE:Protein
                     crystalography[PMID:15547284]"
                     /note="molybdopterin biosynthesis protein MoeA"
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin molybdenumtransferase"
                     /protein_id="YP_177725.1"
                     /db_xref="GeneID:886348"
                     /translation="MRSVQEHQRVVAEMMRACRPITVPLTQAQGLVLGGDVVAPLSLP
                     VFDNSAMDGYAVRAEDTSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGAPV
                     PTGATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLG
                     LAAALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAV
                     VATATAGDDVAQFGAILDRYAVDADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVE
                     FVKVAMQPGMPQGVGRVAGTPIVTLPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHR
                     SAVLTASLTSPRGKRQFRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVE
                     VAAGTQLQVWDLT"
     misc_feature    complement(526149..527351)
                     /gene="moeA2"
                     /locus_tag="Rv0438c"
                     /gene_synonym="moeA3"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; Region: MoeA;
                     cd00887"
                     /db_xref="CDD:238452"
     misc_feature    complement(order(526161..526163,526245..526247,
                     526359..526361,526746..526748,526755..526757,
                     526761..526763,526863..526865,526869..526874,
                     526881..526883,526887..526898,526941..526943,
                     527283..527285))
                     /gene="moeA2"
                     /locus_tag="Rv0438c"
                     /gene_synonym="moeA3"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238452"
     misc_feature    complement(order(526611..526613,526683..526685,
                     526803..526805,526809..526814))
                     /gene="moeA2"
                     /locus_tag="Rv0438c"
                     /gene_synonym="moeA3"
                     /note="putative functional site; other site"
                     /db_xref="CDD:238452"
     misc_feature    complement(order(526431..526433,526440..526442,
                     526452..526457,526605..526613))
                     /gene="moeA2"
                     /locus_tag="Rv0438c"
                     /gene_synonym="moeA3"
                     /note="putative MPT binding site; other site"
                     /db_xref="CDD:238452"
     gene            complement(527379..528314)
                     /locus_tag="Rv0439c"
                     /db_xref="GeneID:886342"
     CDS             complement(527379..528314)
                     /locus_tag="Rv0439c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="dehydrogenase/reductase"
                     /protein_id="NP_214953.1"
                     /db_xref="GeneID:886342"
                     /translation="MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADR
                     GAHVVLAVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPRID
                     VLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGSRVVTVSSQGH
                     RIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRRLGEAGKSTIAVAAHPGGS
                     NTELTRNLPRLIRPVATVLGPLLFQSPEMGALPTLRAATDPTTQGGQYYGPDGFGEQR
                     GHPKVVQSSAQSHDKDLQRRLWTVSEELTGVSFGV"
     misc_feature    complement(527382..528299)
                     /locus_tag="Rv0439c"
                     /note="short chain dehydrogenase; Provisional; Region:
                     PRK06197"
                     /db_xref="CDD:235737"
     gene            528608..530230
                     /gene="groEL2"
                     /locus_tag="Rv0440"
                     /gene_synonym="groEL-2; groL2; hsp60; hsp65"
                     /db_xref="GeneID:886354"
     CDS             528608..530230
                     /gene="groEL2"
                     /locus_tag="Rv0440"
                     /gene_synonym="groEL-2; groL2; hsp60; hsp65"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00296"
                     /note="60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL
                     protein 2) (65 kDa antigen) (heat shock protein 65) (cell
                     wall protein A) (antigen A). Purified 65 kDa antigen can
                     elicit a strong delayed-type hypersensitivity reaction in
                     experimental animals infected with M. tuberculosis. This
                     protein is one of the major immunoreactive proteins of the
                     mycobacteria. This antigen contains epitopes that are
                     common to various species of mycobacteria."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone GroEL"
                     /protein_id="NP_214954.1"
                     /db_xref="GeneID:886354"
                     /translation="MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWG
                     APTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREG
                     LRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLI
                     AEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYI
                     LLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKA
                     PGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGA
                     GDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKH
                     RIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQ
                     IAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIA
                     GLFLTTEAVVADKPEKEKASVPGGGDMGGMDF"
     misc_feature    528608..530197
                     /gene="groEL2"
                     /locus_tag="Rv0440"
                     /gene_synonym="groEL-2; groL2; hsp60; hsp65"
                     /note="chaperonin GroEL; Reviewed; Region: groEL;
                     PRK00013"
                     /db_xref="CDD:234573"
     misc_feature    order(528614..528616,528626..528628,528677..528679,
                     528710..528721,528725..528727,528740..528745,
                     528749..528751,528779..528781,528785..528787,
                     528809..528811,528821..528823,528830..528832,
                     529190..529192,529286..529288,529370..529372,
                     529751..529753,529757..529759,529973..529975,
                     530135..530137,530144..530164)
                     /gene="groEL2"
                     /locus_tag="Rv0440"
                     /gene_synonym="groEL-2; groL2; hsp60; hsp65"
                     /note="ring oligomerisation interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239460"
     misc_feature    order(528695..528703,528863..528865,528875..528877,
                     529052..529054,529793..529795,529844..529846,
                     529958..529960,530075..530077,530081..530083)
                     /gene="groEL2"
                     /locus_tag="Rv0440"
                     /gene_synonym="groEL-2; groL2; hsp60; hsp65"
                     /note="ATP/Mg binding site [chemical binding]; other site"
                     /db_xref="CDD:239460"
     misc_feature    order(528929..528931,529898..529900,529952..529954,
                     529979..529981,529985..529990,529997..529999)
                     /gene="groEL2"
                     /locus_tag="Rv0440"
                     /gene_synonym="groEL-2; groL2; hsp60; hsp65"
                     /note="stacking interactions; other site"
                     /db_xref="CDD:239460"
     misc_feature    order(529025..529027,529157..529159,529178..529180,
                     529724..529726,529826..529831)
                     /gene="groEL2"
                     /locus_tag="Rv0440"
                     /gene_synonym="groEL-2; groL2; hsp60; hsp65"
                     /note="hinge regions; other site"
                     /db_xref="CDD:239460"
     gene            complement(530296..530724)
                     /locus_tag="Rv0441c"
                     /db_xref="GeneID:886344"
     CDS             complement(530296..530724)
                     /locus_tag="Rv0441c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214955.1"
                     /db_xref="GeneID:886344"
                     /translation="MGAKKVDLKRLAAALPDYPFAYLITVDDGHRVHTVAVEPVLREL
                     PDGPDGPRAVVDVGLIGGRTRQNLAHRSEVTLLWPPSDPSGYSLIVDGRAQASDAGPD
                     DDTARCGVVPIRALLHRDAAPDSPTAAKGCLHDCVVFSVP"
     gene            complement(530751..532214)
                     /gene="PPE10"
                     /locus_tag="Rv0442c"
                     /db_xref="GeneID:886340"
     CDS             complement(530751..532214)
                     /gene="PPE10"
                     /locus_tag="Rv0442c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE10"
                     /protein_id="YP_177726.2"
                     /db_xref="GeneID:886340"
                     /translation="MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEELLAS
                     IASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEA
                     ALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFD
                     ASAAVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTG
                     NIGSGNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGN
                     SGTGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAAL
                     GSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPV
                     AAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAV
                     REPSTPGSGIPKSNFYPSPDRESAYASPRIGQPVGSE"
     misc_feature    complement(531720..532193)
                     /gene="PPE10"
                     /locus_tag="Rv0442c"
                     /note="PPE family; Region: PPE; pfam00823"
                     /db_xref="CDD:307116"
     misc_feature    complement(531447..531563)
                     /gene="PPE10"
                     /locus_tag="Rv0442c"
                     /note="Pentapeptide repeats (8 copies); Region:
                     Pentapeptide_2; pfam01469"
                     /db_xref="CDD:279771"
     misc_feature    complement(531291..531401)
                     /gene="PPE10"
                     /locus_tag="Rv0442c"
                     /note="Pentapeptide repeats (8 copies); Region:
                     Pentapeptide_2; pfam01469"
                     /db_xref="CDD:279771"
     gene            532396..532911
                     /locus_tag="Rv0443"
                     /db_xref="GeneID:886336"
     CDS             532396..532911
                     /locus_tag="Rv0443"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214957.1"
                     /db_xref="GeneID:886336"
                     /translation="MASTDAAAQELLRDAFTRLIEHVDELTDGLTDQLACYRPTPSAN
                     SIAWLLWHSARVQDIQVAHVAGVEEVWTRDGWVDRFGLDLPRHDTGYGHRPEDVAKVR
                     APADLLSGYYHAVHKLTLEYIAGMTADELSRVVDTSWNPPVTVSARLVSIVDDCAQHL
                     GQAAYLRGIAR"
     misc_feature    532426..532896
                     /locus_tag="Rv0443"
                     /note="Protein of unknown function (DUF664); Region:
                     DUF664; pfam04978"
                     /db_xref="CDD:309901"
     gene            complement(533091..533789)
                     /gene="rskA"
                     /locus_tag="Rv0444c"
                     /db_xref="GeneID:886346"
     CDS             complement(533091..533789)
                     /gene="rskA"
                     /locus_tag="Rv0444c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis[PMID:17064366]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="anti-sigma-K factor RskA"
                     /protein_id="NP_214958.1"
                     /db_xref="GeneID:886346"
                     /translation="MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAF
                     NDEVRAVRETMAVVSAATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVG
                     LGAFGLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNV
                     APPSRGTVYQMWLLGGAKGPRSAGTMGTAAVTPSTTATLTDLGASTALAFTVEPGTGS
                     PQPTGTILAELPLG"
     misc_feature    complement(533109..533594)
                     /gene="rskA"
                     /locus_tag="Rv0444c"
                     /note="Anti-sigma-K factor rskA; Region: RskA; pfam10099"
                     /db_xref="CDD:313345"
     gene            complement(533833..534396)
                     /gene="sigK"
                     /locus_tag="Rv0445c"
                     /db_xref="GeneID:886334"
     CDS             complement(533833..534396)
                     /gene="sigK"
                     /locus_tag="Rv0445c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF RNA polymerase sigma factor SigK"
                     /protein_id="NP_214959.1"
                     /db_xref="GeneID:886334"
                     /translation="MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVYGLVMRV
                     LRDTGYSEETTQEIYLEVWRNASEFDSAKGSALAWLLTMAHRRAVDRVRCEQAGNQRE
                     VRYGAANVDPASDVVADLAIAGDERRRVTECLKALTDTQRQCIELAYYGGLTYVEVSR
                     RLAANLSTIKSRMRDALRSLRNCLDVS"
     misc_feature    complement(533836..534396)
                     /gene="sigK"
                     /locus_tag="Rv0445c"
                     /note="RNA polymerase sigma factor SigK; Reviewed; Region:
                     PRK09646"
                     /db_xref="CDD:182015"
     gene            complement(534445..535215)
                     /locus_tag="Rv0446c"
                     /db_xref="GeneID:886332"
     CDS             complement(534445..535215)
                     /locus_tag="Rv0446c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214960.1"
                     /db_xref="GeneID:886332"
                     /translation="MVTSVSALAVAVVHSVAFAIGRRIGRYNVVDVVWGLGFVAVAVA
                     AATLGHGDPVRRWLLLALVSTWGLRLSWHMYRKTAGQGEDPRYADLLRGATPVQALRK
                     VFGLQGLLTLFVSFPLQLSAVTGPTPKPLLAVGGVGLAVWLVGITFEAVGDWQLWVFK
                     SDPANRGVIMDRGLWAWTRHPNYFGDACVWWGLWLITINDWAPLATVGSPLLMTYLLV
                     DVSGARLTERYLKGRPGFAEYQRRTAYFVPRPPRSARR"
     misc_feature    complement(534448..535215)
                     /locus_tag="Rv0446c"
                     /note="Steroid 5-alpha reductase family enzyme [General
                     function prediction only]; Region: COG3752"
                     /db_xref="CDD:226275"
     gene            complement(535224..536507)
                     /gene="ufaA1"
                     /locus_tag="Rv0447c"
                     /db_xref="GeneID:886330"
     CDS             complement(535224..536507)
                     /gene="ufaA1"
                     /locus_tag="Rv0447c"
                     /codon_start=1
                     /transl_table=11
                     /product="cyclopropane-fatty-acyl-phospholipid synthase
                     UfaA"
                     /protein_id="NP_214961.1"
                     /db_xref="GeneID:886330"
                     /translation="MTVETSQTPSAAIDSDRWPAVAKVPRGPLAAASAAIANRLLRRT
                     ATHLPLRLVYSDGTATGAADPRAPSLFIHRPDALARRIGRHGLIGFGESYMAGEWSSK
                     ELTRVLTVLAGSVDELVPRSLHWLRPITPTFRPSWPDHSRDQARRNIAVHYDLSNDLF
                     AAFLDETMTYSCAMFTDLLAQPTPAWTELAAAQRRKIDRLLDVAGVQQGSHVLEIGTG
                     WGELCIRAAARGAHIRSVTLSVEQQRLARQRVAAAGFGHRVEIDLCDYRDVDGQYDSV
                     VSVEMIEAVGYRSWPRYFAALEQLVRPGGPVAIQAITMPHHRMLATRHTQTWIQKYIF
                     PGGLLPSTQAIIDITGQHTGLRIVDAASLRPHYAETLRLWRERFMQRRDGLAHLGFDE
                     VFARMWELYLAYSEAGFRSGYLDVYQWTLIREGPP"
     misc_feature    complement(535251..536087)
                     /gene="ufaA1"
                     /locus_tag="Rv0447c"
                     /note="Mycolic acid cyclopropane synthetase; Region: CMAS;
                     pfam02353"
                     /db_xref="CDD:280508"
     gene            complement(536504..537169)
                     /locus_tag="Rv0448c"
                     /db_xref="GeneID:886328"
     CDS             complement(536504..537169)
                     /locus_tag="Rv0448c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214962.1"
                     /db_xref="GeneID:886328"
                     /translation="MHHSFAYRSYSWYVDVDNLPQLPWWLRPFARFHADDHFADPFSC
                     PPHSSLRDRLDAFFAARGLAVPDGRITALLQARVLGYVFNPLSIFWCHDRDGQLRHVI
                     AEVHNTYGGRHAYLLPPADLPVVTAKNFYVSPFHQLAGYYLIRAPRPDRELDVTVTLH
                     RDRRQVCPEFTATLRGQRRPATTRQIAMMQIISPLAPMVVAARIRIQGIRLWLRRVPV
                     VPR"
     misc_feature    complement(536510..537169)
                     /locus_tag="Rv0448c"
                     /note="Protein of unknown function (DUF1365); Region:
                     DUF1365; cl17838"
                     /db_xref="CDD:327439"
     gene            complement(537229..538548)
                     /locus_tag="Rv0449c"
                     /db_xref="GeneID:886326"
     CDS             complement(537229..538548)
                     /locus_tag="Rv0449c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214963.1"
                     /db_xref="GeneID:886326"
                     /translation="MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHA
                     HTHYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADD
                     IGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLE
                     AFLSRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTW
                     RTVTGGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHP
                     DQALLLLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQV
                     VVSYDISRLMRLDGGRRYLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTL
                     GDNRVVFAGAYHGWGFHEDGAASGLRAARRLGADWPAAIPQEAMVAC"
     misc_feature    complement(537232..538548)
                     /locus_tag="Rv0449c"
                     /note="Predicted NAD/FAD-binding protein [General function
                     prediction only]; Region: COG2907"
                     /db_xref="CDD:225459"
     gene            complement(538588..541491)
                     /gene="mmpL4"
                     /locus_tag="Rv0450c"
                     /db_xref="GeneID:886323"
     CDS             complement(538588..541491)
                     /gene="mmpL4"
                     /locus_tag="Rv0450c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00211"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane transport protein MmpL4"
                     /protein_id="NP_214964.1"
                     /db_xref="GeneID:886323"
                     /translation="MSTKFANDSNTNARPEKPFIARMIHAFAVPIILGWLAVCVVVTV
                     FVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGNQPLGDAAH
                     KYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANE
                     SVEAVRSIVESTPAPPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLV
                     YRSIITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIF
                     IIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPYFQTLGIP
                     CAVGMLVAVAVALTLGPAVLHVGSRFGLFDPKRLLKVRGWRRVGTVVVRWPLPVLVAT
                     CAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYAAADRHFSQARMKPEILMIESDHD
                     MRNPADFLVLDKLAKGIFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIK
                     YQRDRANDMLKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHV
                     ADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDR
                     LMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDD
                     SFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAIRTAAEES
                     LKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISSLCLIFIIMLIITRAFIAAAV
                     IVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQE
                     IGAGLKTGIIRSMGGTGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTL
                     IVRSFMTPSIAALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG"
     misc_feature    complement(538687..541413)
                     /gene="mmpL4"
                     /locus_tag="Rv0450c"
                     /note="Transport protein; Region: actII; TIGR00833"
                     /db_xref="CDD:129913"
     gene            complement(541488..541910)
                     /gene="mmpS4"
                     /locus_tag="Rv0451c"
                     /db_xref="GeneID:886321"
     CDS             complement(541488..541910)
                     /gene="mmpS4"
                     /locus_tag="Rv0451c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein MmpS4"
                     /protein_id="NP_214965.1"
                     /db_xref="GeneID:886321"
                     /translation="MLMRTWIPLVILVVVIVGGFTVHRIRGFFGSENRPSYSDTNLEN
                     SKPFNPKHLTYEIFGPPGTVADISYFDVNSEPQRVDGAVLPWSLHITTNDAAVMGNIV
                     AQGNSDSIGCRITVDGKVRAERVSNEVNAYTYCLVKSA"
     misc_feature    complement(541494..541907)
                     /gene="mmpS4"
                     /locus_tag="Rv0451c"
                     /note="Mycobacterium membrane protein; Region:
                     Mycobact_memb; pfam05423"
                     /db_xref="CDD:283157"
     gene            542142..542852
                     /locus_tag="Rv0452"
                     /db_xref="GeneID:886319"
     CDS             542142..542852
                     /locus_tag="Rv0452"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214966.1"
                     /db_xref="GeneID:886319"
                     /translation="MRYPLAVAQLGFQRARTEENKRQRAAALVEAARSLALETGVASV
                     TLTAVAGRAGIHYSAVRRYFTSHKEVLLHLAAEGWARWSGTVCEQLGEPGPMSAPRVA
                     EALANGLAADPLFCDLLANLHLHLEQEVDVDRVIEVKRTSIAAVIALVDAIESALPAL
                     GRSGAFDILLAAYSLAATLWQIANPPERLTDAYAEEPELLPPEWNLDFAAALTRLLTA
                     TLLGLLAGSPCECRSPTR"
     misc_feature    542181..542729
                     /locus_tag="Rv0452"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            543174..544730
                     /gene="PPE11"
                     /locus_tag="Rv0453"
                     /db_xref="GeneID:886317"
     CDS             543174..544730
                     /gene="PPE11"
                     /locus_tag="Rv0453"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /codon_start=1
                     /transl_table=11
                     /product="PPE family protein PPE11"
                     /protein_id="YP_177727.1"
                     /db_xref="GeneID:886317"
                     /translation="MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGREYAA
                     VAEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAAAARLEAVTAAYA
                     AALVAMPTLAELAANHATHGAMVATNFFGINTIPIAVNEADYVRMWLQAATTMATYQA
                     VADSAVRSIPDSVPPPRILKSNAQSQHSSSNNSGGADPVDDFIAEILKIITGGRVIWD
                     PEAGTVNGLPYDAYTNPGTLMWWIARSLELLQDFQEFAKLLFTNPVKAFQFLVDLILF
                     DWPTHMLQLATWLAENPQLLVAALTPAISGLGAVSGLAGLTGLVPQPPVVPAPAPDAV
                     VPTVLPLAGTATPTTAPASAPAAGAAPGPPAGTATATSASVPTSAGGFPPYLVGSGPG
                     IDFDAGTPAGSRRAQPAADNVTAVAAAQVSARHQARRRRRAAAKERGNADEFVDMDSG
                     PAIPPSGERDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRMPMLPGA
                     WDLGTWDRGD"
     misc_feature    543186..544712
                     /gene="PPE11"
                     /locus_tag="Rv0453"
                     /note="PPE-repeat protein [Function unknown]; Region:
                     COG5651"
                     /db_xref="CDD:227938"
     gene            complement(545375..545821)
                     /locus_tag="Rv0455c"
                     /db_xref="GeneID:886314"
     CDS             complement(545375..545821)
                     /locus_tag="Rv0455c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214969.1"
                     /db_xref="GeneID:886314"
                     /translation="MSRLSSILRAGAAFLVLGIAAATFPQSAAADSTEDFPIPRRMIA
                     TTCDAEQYLAAVRDTSPVYYQRYMIDFNNHANLQQATINKAHWFFSLSPAERRDYSEH
                     FYNGDPLTFAWVNHMKIFFNNKGVVAKGTEVCNGYPAGDMSVWNWA"
     misc_feature    complement(545381..545725)
                     /locus_tag="Rv0455c"
                     /note="Domain of unknown function (DUF5078); Region:
                     DUF5078; pfam16877"
                     /db_xref="CDD:318969"
     gene            complement(545889..546803)
                     /gene="echA2"
                     /locus_tag="Rv0456c"
                     /db_xref="GeneID:886312"
     CDS             complement(545889..546803)
                     /gene="echA2"
                     /locus_tag="Rv0456c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase EchA2"
                     /protein_id="NP_214970.1"
                     /db_xref="GeneID:886312"
                     /translation="MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIG
                     LAERDQDIKVIVLRGAGRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTARETG
                     PTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWGAYLT
                     GMWLYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELARIPL
                     SQLQAQKLIVNQAYENMGLASTQLLGGILDGLMRNTPDALEFIRTAQTQGVRAAVERR
                     DGPFGDYSQAPPELRPDPTHVITPDGSM"
     misc_feature    complement(545904..546797)
                     /gene="echA2"
                     /locus_tag="Rv0456c"
                     /note="enoyl-CoA hydratase; Provisional; Region: PRK12478"
                     /db_xref="CDD:183548"
     misc_feature    complement(order(546342..546344,546351..546356,
                     546420..546428,546432..546434,546594..546608,
                     546618..546620,546714..546716,546720..546722))
                     /gene="echA2"
                     /locus_tag="Rv0456c"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:119339"
     misc_feature    complement(order(546420..546422,546600..546602))
                     /gene="echA2"
                     /locus_tag="Rv0456c"
                     /note="oxyanion hole (OAH) forming residues; other site"
                     /db_xref="CDD:119339"
     misc_feature    complement(order(546165..546170,546177..546179,
                     546222..546224,546231..546233,546264..546266,
                     546273..546278,546282..546287,546291..546296,
                     546300..546302,546306..546314,546318..546320,
                     546336..546338,546342..546350,546384..546395,
                     546456..546458,546480..546482))
                     /gene="echA2"
                     /locus_tag="Rv0456c"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:119339"
     gene            complement(547076..547357)
                     /gene="mazF1"
                     /locus_tag="Rv0456A"
                     /gene_synonym="mt2"
                     /db_xref="GeneID:3205039"
     CDS             complement(547076..547357)
                     /gene="mazF1"
                     /locus_tag="Rv0456A"
                     /gene_synonym="mt2"
                     /note="part of toxin-antitoxin (TA) operon with Rv0456B"
                     /codon_start=1
                     /transl_table=11
                     /product="toxin MazF1"
                     /protein_id="YP_177621.1"
                     /db_xref="GeneID:3205039"
                     /translation="MLRGEIWQVDLDPARGSAANMRRPAVIVSNDRANAAAIRLDRGV
                     VPVVPVTSNTEKVPIPGVVAGSERWPGRRFEGAGPAGWIRRCATSPLPS"
     misc_feature    complement(<547175..547351)
                     /gene="mazF1"
                     /locus_tag="Rv0456A"
                     /gene_synonym="mt2"
                     /note="PemK-like, MazF-like toxin of type II
                     toxin-antitoxin system; Region: PemK_toxin; pfam02452"
                     /db_xref="CDD:308199"
     gene            complement(547344..547517)
                     /gene="mazE1"
                     /locus_tag="Rv0456B"
                     /db_xref="GeneID:14515889"
     CDS             complement(547344..547517)
                     /gene="mazE1"
                     /locus_tag="Rv0456B"
                     /note="part of toxin-antitoxin (TA) operon with Rv0456A"
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin MazE1"
                     /protein_id="YP_007409102.1"
                     /db_xref="GeneID:14515889"
                     /translation="MTTYYYVLLSVTTWVGLRHEAKRELVYRGRRSIGRMPREWACRR
                     SRRFAANGVDAAR"
     repeat_region   complement(547488..547517)
                     /gene="mazE1"
                     /locus_tag="Rv0456B"
                     /note="3 copies of a 10 bp near-perfect direct
                     repeat,ATTACTACCTATTACTACGTATTACTATCT"
     gene            complement(547586..549607)
                     /locus_tag="Rv0457c"
                     /db_xref="GeneID:886310"
     CDS             complement(547586..549607)
                     /locus_tag="Rv0457c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase"
                     /protein_id="NP_214971.1"
                     /db_xref="GeneID:886310"
                     /translation="MTFEPAPDGADPYLWLEDVTGAEALDWVRARNKPTTAAFCDAEF
                     ERMRVEALEVLDTDARIPYVNRRGNYLYNFWRDAANPRGLWRRTTLDSYRTDSPGWDV
                     LIDVDELGRADDQKWVWGGAGVIEPDYTRALIGLSPGGSDASIVREFDMLTREFVEDG
                     FQLPPAKSQITWEDPDTVLLGTDFGGDSLTTSGYPRVIKRWRRGKPLADAETIFEGAG
                     TDVRVNASADRTPGFERTLLGRALDFWNEEVYELRGSELIRIEAPTDASVSIHRDWLL
                     IELRTDWTVATTRYTAGSLLAAEYDEFLAGSAELQVVFEPDEHTALYQYAWTRDRLLI
                     VTLADVASRVEIATPGSWRREPLSGIPAATNTVIVSADSHGDEFFLDSSGFDTPSRLM
                     RGTDDGRLAEIKSAPAFFDAENMAVTQYFATSDDGTSIPYFVVRRTDADNPGPTLLNG
                     YGGFETSRTPTYDGVLGRLWLARGGTYALANIRGGGEYGPGWHTQAMREGRDKVAQDF
                     AAVATDLVTRGITTAEQLGARGGSNGGLLMGIMLTGYPEKFGALVCDVPLLDMKRYHL
                     LLAGASWMAEYGDPDNPDDWKFISEYSPYQNISANRKYPPVLMTTSTRDDRVHPGHAR
                     KMTAALQAAGHPVWYYENIEGGHAGAADNAQIAFKSALSFAFLWRMLAG"
     misc_feature    complement(547592..549586)
                     /locus_tag="Rv0457c"
                     /note="Prolyl oligopeptidase PreP, S9A serine peptidase
                     family [Amino acid transport and metabolism]; Region:
                     PreP; COG1505"
                     /db_xref="CDD:224422"
     gene            549675..551198
                     /locus_tag="Rv0458"
                     /db_xref="GeneID:886306"
     CDS             549675..551198
                     /locus_tag="Rv0458"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase"
                     /protein_id="NP_214972.1"
                     /db_xref="GeneID:886306"
                     /translation="MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
                     GQPFCEVPRSDAADIDKALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALAVA
                     EVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVG
                     QIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVN
                     GFGAEAGKPLASSDRIAKVAFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV
                     LAAHDDFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDP
                     LDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFT
                     GTNNMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTAYRAGRDI
                     QAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKNLLVSYSDKALGFF"
     misc_feature    549732..551171
                     /locus_tag="Rv0458"
                     /note="Ralstonia eutrophus NAD+-dependent acetaldehyde
                     dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116"
                     /db_xref="CDD:143434"
     misc_feature    order(550158..550172,550194..550196,550239..550241,
                     550245..550250,550389..550400,550407..550409,
                     550416..550421,550461..550469,550578..550580,
                     550881..550883,550887..550889,550965..550967,
                     551079..551081)
                     /locus_tag="Rv0458"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:143434"
     misc_feature    order(550170..550172,550461..550463,550569..550571,
                     550578..550580)
                     /locus_tag="Rv0458"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143434"
     gene            551198..551689
                     /locus_tag="Rv0459"
                     /db_xref="GeneID:886372"
     CDS             551198..551689
                     /locus_tag="Rv0459"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214973.1"
                     /db_xref="GeneID:886372"
                     /translation="MNAPAGVLITAEAAALLAGLQDRHGPVMFHQSGGCCDGSAPMCY
                     PRADFLVGDRDILLGVLDVGEDGVPVWISGPQYQAWKHTQLIIDVVPGRGGGFSLEAP
                     EGVRFLSRGRVFSDAEKAMREAAPVITGAAYECGERPLVRGLVVDLDDPDATPGVCRA
                     SRR"
     misc_feature    551198..551557
                     /locus_tag="Rv0459"
                     /note="Protein of unknown function (DUF779); Region:
                     DUF779; cl01432"
                     /db_xref="CDD:321502"
     gene            551749..551988
                     /locus_tag="Rv0460"
                     /db_xref="GeneID:886304"
     CDS             551749..551988
                     /locus_tag="Rv0460"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214974.1"
                     /db_xref="GeneID:886304"
                     /translation="MLVGNAIGLLAGVACSVLVHARIRPDIVIAMVVGIPSAIGLLVI
                     LFSGRRWVTMLGAFILALAPGWFGVLVAIQVASSG"
     misc_feature    551749..551982
                     /locus_tag="Rv0460"
                     /note="Putative holin; Region: Holin_9; pfam16936"
                     /db_xref="CDD:293541"
     gene            552026..552550
                     /locus_tag="Rv0461"
                     /db_xref="GeneID:886302"
     CDS             552026..552550
                     /locus_tag="Rv0461"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214975.1"
                     /db_xref="GeneID:886302"
                     /translation="MPDFDTGAHSQRFLSLAGQQDRAGKSWPGSTPKPQEDPVGVAPS
                     ASVEVLGSEPAATLAHSVTVPGRYTYLKWWKFVLVVLGVWIGAGEVGLSLFYWWYHTL
                     DKTAAVFVVLVYVVACTVGGLILALVPGRPLITALSLGVMSGPFASVAAAAPLYGYYY
                     CERMSHCLVGVIPY"
     gene            552614..554008
                     /gene="lpdC"
                     /locus_tag="Rv0462"
                     /gene_synonym="CIP50; TB49.2"
                     /db_xref="GeneID:886300"
     CDS             552614..554008
                     /gene="lpdC"
                     /locus_tag="Rv0462"
                     /gene_synonym="CIP50; TB49.2"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis[PMID:21238944]"
                     /experiment="DESCRIPTION:Gene expression, protein
                     characterization[PMID:11560483]"
                     /experiment="DESCRIPTION:Mutation analysis, protein
                     characterization[PMID:16093239]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Belongs to the pyridine nucleotide-disulfide
                     oxidoreductases class-I"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide dehydrogenase"
                     /protein_id="NP_214976.1"
                     /db_xref="GeneID:886300"
                     /translation="MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNV
                     GCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMK
                     KNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVT
                     YEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEI
                     EKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGY
                     GLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGA
                     ETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPS
                     GFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEAL
                     QECFHGLVGHMINF"
     misc_feature    552614..554005
                     /gene="lpdC"
                     /locus_tag="Rv0462"
                     /gene_synonym="CIP50; TB49.2"
                     /note="dihydrolipoamide dehydrogenase; Reviewed; Region:
                     PRK07818"
                     /db_xref="CDD:236106"
     gene            554016..554309
                     /locus_tag="Rv0463"
                     /db_xref="GeneID:886299"
     CDS             554016..554309
                     /locus_tag="Rv0463"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214977.1"
                     /db_xref="GeneID:886299"
                     /translation="MTRRASTDTPQIIMGAIGGVVTGYILWLAAISVGDGLTTVSQWS
                     RVVLLLSVLVAVCGAAGGLRLRSRGKLAWSAFAFSLPIPPVVLTVAVLADIYL"
     gene            complement(554313..554885)
                     /locus_tag="Rv0464c"
                     /db_xref="GeneID:886296"
     CDS             complement(554313..554885)
                     /locus_tag="Rv0464c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214978.1"
                     /db_xref="GeneID:886296"
                     /translation="MTGQNGQVARISPGKFRQLGPVNWLVAKLAARAVGAPQMHLFTT
                     LGYRQYLFWTFAIYTGRLLHGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLD
                     ANTQATIFAWPDVPDGDGPRKVLSARQQALLQATDELIKDRTITAGTWERLATHLDPR
                     LLIEFCLLATQYDAIAATITALAIPPDNPQ"
     misc_feature    complement(554370..554855)
                     /locus_tag="Rv0464c"
                     /note="Alkylhydroperoxidase family enzyme, contains CxxC
                     motif [Inorganic ion transport and metabolism]; Region:
                     YciW; COG2128"
                     /db_xref="CDD:225039"
     gene            complement(554882..556306)
                     /locus_tag="Rv0465c"
                     /db_xref="GeneID:886320"
     CDS             complement(554882..556306)
                     /locus_tag="Rv0465c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_214979.1"
                     /db_xref="GeneID:886320"
                     /translation="MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRP
                     LTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHP
                     GLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHAL
                     DTAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEIS
                     SHLSPGQQVFKMAAELAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLP
                     YRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMS
                     KRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAAR
                     YGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAF
                     PALGRALDLDEHRSTVSPYLVKQL"
     misc_feature    complement(556115..556288)
                     /locus_tag="Rv0465c"
                     /note="Helix-turn-helix XRE-family like proteins.
                     Prokaryotic DNA binding proteins belonging to the
                     xenobiotic response element family of transcriptional
                     regulators; Region: HTH_XRE; cd00093"
                     /db_xref="CDD:238045"
     misc_feature    complement(order(556187..556189,556262..556264,
                     556274..556276))
                     /locus_tag="Rv0465c"
                     /note="non-specific DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:238045"
     misc_feature    complement(order(556190..556192,556265..556267))
                     /locus_tag="Rv0465c"
                     /note="salt bridge; other site"
                     /db_xref="CDD:238045"
     misc_feature    complement(order(556184..556189,556199..556201,
                     556208..556210,556241..556246))
                     /locus_tag="Rv0465c"
                     /note="sequence-specific DNA binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:238045"
     misc_feature    complement(554891..555892)
                     /locus_tag="Rv0465c"
                     /note="Predicted transcriptional regulator [General
                     function prediction only]; Region: COG3800"
                     /db_xref="CDD:226322"
     gene            556458..557252
                     /locus_tag="Rv0466"
                     /db_xref="GeneID:886294"
     CDS             556458..557252
                     /locus_tag="Rv0466"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214980.1"
                     /db_xref="GeneID:886294"
                     /translation="MSLDKKLMPVPDGHPDVFDREWPLRVGDIDRAGRLRLDAACRHI
                     QDIGQDQLREMGFEETHPLWIVRRTMVDLIRPIEFGDMLRCRRWCSGTSNRWCEMRVR
                     VDGRKGGLIESEAFWIHVNRETEMPARIADDFLAGLHRTTSVDRLRWKGYLKPGSRDD
                     ASEIHEFPVRVTDIDLFDHMNNAVYWSVIEDYLASHAELLRGPLRVTIEHEAPVALGD
                     KLEIISHVHPAGSTEIFGPGLVDRAVTTLTYVVGDEPKAVASLFNL"
     misc_feature    556458..557246
                     /locus_tag="Rv0466"
                     /note="Acyl-ACP thioesterase [Lipid transport and
                     metabolism]; Region: FatA; COG3884"
                     /db_xref="CDD:226401"
     gene            557527..558813
                     /gene="icl1"
                     /locus_tag="Rv0467"
                     /gene_synonym="aceA; icl"
                     /db_xref="GeneID:886291"
     CDS             557527..558813
                     /gene="icl1"
                     /locus_tag="Rv0467"
                     /gene_synonym="aceA; icl"
                     /experiment="DESCRIPTION:Gene expression, protein
                     purification and characterization[PMID:10932251]"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:15895072]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="Icl (isocitrase) (isocitratase)"
                     /codon_start=1
                     /transl_table=11
                     /product="isocitrate lyase"
                     /protein_id="YP_177728.1"
                     /db_xref="GeneID:886291"
                     /translation="MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVE
                     EHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLS
                     GHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGG
                     ALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADV
                     ADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYA
                     PFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQK
                     ELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATK
                     HQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH"
     misc_feature    557530..558810
                     /gene="icl1"
                     /locus_tag="Rv0467"
                     /gene_synonym="aceA; icl"
                     /note="isocitrate lyase; Provisional; Region: PRK15063"
                     /db_xref="CDD:237893"
     misc_feature    order(557725..557736,557740..557754,557758..557763,
                     557770..557772,557776..557784,557803..557808,
                     557812..557820,557842..557847,557854..557865,
                     557869..557874,557881..557886,557890..557895,
                     557902..557907,557992..557997,558001..558003,
                     558019..558024,558031..558036,558043..558045,
                     558055..558057,558145..558147,558154..558159,
                     558163..558174,558193..558198,558364..558366,
                     558589..558603,558607..558615)
                     /gene="icl1"
                     /locus_tag="Rv0467"
                     /gene_synonym="aceA; icl"
                     /note="oligomerization interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:119341"
     misc_feature    order(557791..557793,557797..557805,557848..557850,
                     557983..557985,557989..557991,558070..558072,
                     558208..558210,558379..558381,558463..558465,
                     558469..558471,558565..558567)
                     /gene="icl1"
                     /locus_tag="Rv0467"
                     /gene_synonym="aceA; icl"
                     /note="active site"
                     /db_xref="CDD:119341"
     misc_feature    order(557983..557985,557989..557991,558064..558066,
                     558070..558072)
                     /gene="icl1"
                     /locus_tag="Rv0467"
                     /gene_synonym="aceA; icl"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:119341"
     gene            558895..559755
                     /gene="fadB2"
                     /locus_tag="Rv0468"
                     /db_xref="GeneID:886288"
     CDS             558895..559755
                     /gene="fadB2"
                     /locus_tag="Rv0468"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:20378648]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="beta-hydroxybutyryl-CoA dehydrogenase (BHBD)"
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyryl-CoA dehydrogenase"
                     /protein_id="NP_214982.1"
                     /db_xref="GeneID:886288"
                     /translation="MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAG
                     RNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEI
                     FAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTL
                     VTDEAAAARTEEFASTVLGKQVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDV
                     DKAVVAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLG
                     KKSGRGFYTY"
     misc_feature    558895..559752
                     /gene="fadB2"
                     /locus_tag="Rv0468"
                     /note="3-hydroxybutyryl-CoA dehydrogenase; Validated;
                     Region: PRK07819"
                     /db_xref="CDD:181133"
     gene            559888..560748
                     /gene="umaA"
                     /locus_tag="Rv0469"
                     /gene_synonym="umaA1"
                     /db_xref="GeneID:886286"
     CDS             559888..560748
                     /gene="umaA"
                     /locus_tag="Rv0469"
                     /gene_synonym="umaA1"
                     /experiment="DESCRIPTION:Gene expression[PMID:7604045]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="mycolic acid synthase UmaA"
                     /protein_id="YP_177729.1"
                     /db_xref="GeneID:886286"
                     /translation="MTELRPFYEESQSIYDVSDEFFSLFLDPTMAYTCAYFEREDMTL
                     EEAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGLQRAIENYDVNVIGITLSRNQFEYS
                     KAKLAKIPTERSVQVRLQGWDEFTDKVDRIVSIGAFEAFKMERYAAFFERSYDILPDD
                     GRMLLHTILTYTQKQMHEMGVKVTMSDVRFMKFIGEEIFPGGQLPAQEDIFKFAQAAD
                     FSVEKVQLLQQHYARTLNIWAANLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGI
                     SNVGQFTLTK"
     misc_feature    559897..560733
                     /gene="umaA"
                     /locus_tag="Rv0469"
                     /gene_synonym="umaA1"
                     /note="Mycolic acid cyclopropane synthetase; Region: CMAS;
                     pfam02353"
                     /db_xref="CDD:280508"
     gene            complement(560848..561711)
                     /gene="pcaA"
                     /locus_tag="Rv0470c"
                     /gene_synonym="umaA2"
                     /db_xref="GeneID:886284"
     CDS             complement(560848..561711)
                     /gene="pcaA"
                     /locus_tag="Rv0470c"
                     /gene_synonym="umaA2"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis, protein purification and
                     characterization[PMID:22621931]"
                     /experiment="DESCRIPTION:Gene expression, mutation
                     analysis[PMID:10882107]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="mycolic acid synthase PcaA"
                     /codon_start=1
                     /transl_table=11
                     /product="cyclopropane mycolic acid synthase"
                     /protein_id="YP_177730.1"
                     /db_xref="GeneID:886284"
                     /translation="MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
                     LQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAGH
                     VQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGHQRYHHFFEVTHRTLPA
                     DGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKFILAEIFPGGWLPSIPTVHEYAEKV
                     GFRVTAVQSLQLHYARTLDMWATALEANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQG
                     YTDVDQFTLEK"
     misc_feature    complement(560863..561702)
                     /gene="pcaA"
                     /locus_tag="Rv0470c"
                     /gene_synonym="umaA2"
                     /note="Mycolic acid cyclopropane synthetase; Region: CMAS;
                     pfam02353"
                     /db_xref="CDD:280508"
     gene            complement(561854..562294)
                     /locus_tag="Rv0470A"
                     /db_xref="GeneID:3205059"
     CDS             complement(561854..562294)
                     /locus_tag="Rv0470A"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_177622.1"
                     /db_xref="GeneID:3205059"
                     /translation="MGAGGWEVVLASLPYGLLCTTVLMGKHIDKIGYDEPLGIRTLPV
                     LLGETCARTVTLAMMVGFYLLIAVNVMLAAMPWPRCWSPGRCPGWRKCGPISCDGGPS
                     SRHRRFRCGRCGMPRWPGCTCVRPVRCWLWAWRSVPGGAPGDFR"
     misc_feature    complement(562061..>562279)
                     /locus_tag="Rv0470A"
                     /note="UbiA family of prenyltransferases (PTases); Region:
                     PT_UbiA; cl00337"
                     /db_xref="CDD:320916"
     gene            complement(562225..562713)
                     /locus_tag="Rv0471c"
                     /db_xref="GeneID:886280"
     CDS             complement(562225..562713)
                     /locus_tag="Rv0471c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214985.1"
                     /db_xref="GeneID:886280"
                     /translation="MPDAGAGSRLRSWAYALRTTNPPADGPTDTVTRWLVVTRAAVLP
                     MTLVSGLVAGLLAIGEPGLDWRWLVLWWESHAPHIANNLMNDLYDTDVGTDSATYARA
                     RYAQHPAATGANRAAYTTPRRTTSCGSPERALEPTTPRWARAVGRSCWRRSPTGCCAP
                     RC"
     misc_feature    complement(<562417..562602)
                     /locus_tag="Rv0471c"
                     /note="UbiA family of prenyltransferases (PTases); Region:
                     PT_UbiA; cl00337"
                     /db_xref="CDD:320916"
     gene            complement(562723..563427)
                     /locus_tag="Rv0472c"
                     /db_xref="GeneID:886308"
     CDS             complement(562723..563427)
                     /locus_tag="Rv0472c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_214986.1"
                     /db_xref="GeneID:886308"
                     /translation="MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRF
                     LSMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELT
                     REIIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMD
                     TGGVEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKF
                     REQPHPSPIVPAWGQV"
     misc_feature    complement(562828..563361)
                     /locus_tag="Rv0472c"
                     /note="DNA-binding transcriptional regulator, AcrR family
                     [Transcription]; Region: AcrR; COG1309"
                     /db_xref="CDD:224228"
     gene            563564..564934
                     /locus_tag="Rv0473"
                     /db_xref="GeneID:886279"
     CDS             563564..564934
                     /locus_tag="Rv0473"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214987.2"
                     /db_xref="GeneID:886279"
                     /translation="MVAHRAEVSGSPPPRLNLSTQPTVARRVRASFAESFAAADPEAD
                     AARRMALRRMKVVAVGFLVGATGVFLACRWAQADGADHAWLGYLGAAAEAGMVGALAD
                     WFAVTALFKHPLGIPIPHTAIIKRKKDQLGEGLGTFVRENFLSPPVVETKLRDAQIPS
                     RLGKWLSEATHAQRVAAETATVLRVLVELLRDEDIQQVIDRMIVRRIAEPQWGPPAGR
                     VLATLLAENRQEAFIQLLADRAFQWSLNAGVVIQRVVERDSPSWSPRFIDHLVGDRIH
                     RELMEFTDKVRRNPDHELRRSATRFLFDFADDLQHDPATVARADAIKEELMARDEIAT
                     AAAAAWKTLKRLVLEGVDDPSSALRTRITDAVIRIGESLRDDADLRDKVDSWTVRAAQ
                     HLVSEYGVEITAIITETIERWDAEEASRRIELHVGRDLQFIRINGTVVGAMAGLAIYA
                     IAQLLF"
     misc_feature    563702..564931
                     /locus_tag="Rv0473"
                     /note="Uncharacterized membrane-anchored protein YjiN,
                     DUF445 family [Function unknown]; Region: YjiN; COG2733"
                     /db_xref="CDD:225347"
     gene            565021..565443
                     /locus_tag="Rv0474"
                     /db_xref="GeneID:886276"
     CDS             565021..565443
                     /locus_tag="Rv0474"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_214988.1"
                     /db_xref="GeneID:886276"
                     /translation="MSSEEKLAAKVSTKASDVASDIGSFIRSQRETAHVSMRQLAERS
                     GVSNPYLSQVERGLRKPSADVLSQIAKALRVSAEVLYVRAGILEPSETSQVRDAIITD
                     TAITERQKQILLDIYASFTHQNEATREECPSDPTPTDD"
     misc_feature    565087..565260
                     /locus_tag="Rv0474"
                     /note="Helix-turn-helix XRE-family like proteins.
                     Prokaryotic DNA binding proteins belonging to the
                     xenobiotic response element family of transcriptional
                     regulators; Region: HTH_XRE; cd00093"
                     /db_xref="CDD:238045"
     misc_feature    order(565099..565101,565111..565113,565186..565188)
                     /locus_tag="Rv0474"
                     /note="non-specific DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:238045"
     misc_feature    order(565108..565110,565183..565185)
                     /locus_tag="Rv0474"
                     /note="salt bridge; other site"
                     /db_xref="CDD:238045"
     misc_feature    order(565129..565134,565165..565167,565174..565176,
                     565186..565191)
                     /locus_tag="Rv0474"
                     /note="sequence-specific DNA binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:238045"
     gene            565797..566396
                     /gene="hbhA"
                     /locus_tag="Rv0475"
                     /db_xref="GeneID:886272"
     CDS             565797..566396
                     /gene="hbhA"
                     /locus_tag="Rv0475"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Gene expression, protein
                     characterization[PMID:9770536]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="iron-regulated adhesin A core mycobacterial gene;
                     conserved in mycobacterial strains (See Marmiesse et al.,
                     2004 PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="heparin binding hemagglutinin HbhA"
                     /protein_id="NP_214989.1"
                     /db_xref="GeneID:886272"
                     /translation="MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRT
                     DTRSRVEESRARLTKLQEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERG
                     EAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELP
                     KKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK"
     gene            566508..566771
                     /locus_tag="Rv0476"
                     /db_xref="GeneID:886282"
     CDS             566508..566771
                     /locus_tag="Rv0476"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00606"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_214990.1"
                     /db_xref="GeneID:886282"
                     /translation="MLVLLVAVLVTAVYAFVHAALQRPDAYTAADKLTKPVWLVILGA
                     AVALASILYPVLGVLGMAMSACASGVYLVDVRPKLLEIQGKSR"
     misc_feature    <566547..566759
                     /locus_tag="Rv0476"
                     /note="Protein of unknown function (DUF2516); Region:
                     DUF2516; pfam10724"
                     /db_xref="CDD:313846"
     gene            566776..567222
                     /locus_tag="Rv0477"
                     /db_xref="GeneID:886273"
     CDS             566776..567222
                     /locus_tag="Rv0477"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:17443846]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214991.1"
                     /db_xref="GeneID:886273"
                     /translation="MKALVAVSAVAVVALLGVSSAQADPEADPGAGEANYGGPPSSPR
                     LVDHTEWAQWGSLPSLRVYPSQVGRTASRRLGMAAADAAWAEVLALSPEADTAGMRAQ
                     FICHWQYAEIRQPGKPSWNLEPWRPVVDDSEMLASGCNPGSPEESF"
     misc_feature    566911..567201
                     /locus_tag="Rv0477"
                     /note="Protein of unknown function (DUF2599); Region:
                     DUF2599; pfam10783"
                     /db_xref="CDD:313892"
     gene            567222..567896
                     /gene="deoC"
                     /locus_tag="Rv0478"
                     /db_xref="GeneID:888425"
     CDS             567222..567896
                     /gene="deoC"
                     /locus_tag="Rv0478"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="phosphodeoxyriboaldolase (deoxyriboaldolase)
                     Belongs to the DEOC/FBAB family of aldolases, DEOC
                     subfamily."
                     /codon_start=1
                     /transl_table=11
                     /product="2-deoxyribose-5-phosphate aldolase"
                     /protein_id="NP_214992.1"
                     /db_xref="GeneID:888425"
                     /translation="MLGQPTRAQLAALVDHTLLKPETTRADVAALVAEAAELGVYAVC
                     VSPSMVPVAVQAGGVRVAAVTGFPSGKHVSSVKAHEAAAALASGASEIDMVIDIGAAL
                     CGDIDAVRSDIEAVRAAAAGAVLKVIVESAVLLGQSNAHTLVDACRAAEDAGADFVKT
                     STGCHPAGGATVRAVELMAETVGPRLGVKASGGIRTAADAVAMLNAGATRLGLSGTRA
                     VLDGLS"
     misc_feature    567234..567890
                     /gene="deoC"
                     /locus_tag="Rv0478"
                     /note="deoxyribose-phosphate aldolase; Provisional;
                     Region: PRK00507"
                     /db_xref="CDD:234784"
     gene            complement(567921..568967)
                     /locus_tag="Rv0479c"
                     /db_xref="GeneID:885535"
     CDS             complement(567921..568967)
                     /locus_tag="Rv0479c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_214993.1"
                     /db_xref="GeneID:885535"
                     /translation="MTNPQGPPNDPSPWARPGDQGPLARPPASSEASTGRLRPGEPAG
                     HIQEPVSPPTQPEQQPQTEHLAASHAHTRRSGRQAAHQAWDPTGLLAAQEEEPAAVKT
                     KRRARRDPLTVFLVLIIVFSLVLAGLIGGELYARHVANSKVAQAVACVVKDQATASFG
                     VAPLLLWQVATRHFTNISVETAGNQIRDAKGMQIKLTIQNVRLKNTPNSRGTIGALDA
                     TITWSSEGIKESVQNAIPILGAFVTSSVVTHPADGTVELKGLLNNITAKPIVAGKGLE
                     LQIINFNTLGFSLPKETVQSTLNEFTSSLTKNYPLGIHADSVQVTSTGVVSRFSTRDA
                     AIPTGIQNPCFSHI"
     misc_feature    complement(567990..568565)
                     /locus_tag="Rv0479c"
                     /note="Protein of unknown function (DUF2993); Region:
                     DUF2993; pfam11209"
                     /db_xref="CDD:314205"
     gene            complement(568964..569806)
                     /locus_tag="Rv0480c"
                     /db_xref="GeneID:887163"
     CDS             complement(568964..569806)
                     /locus_tag="Rv0480c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="NP_214994.2"
                     /db_xref="GeneID:887163"
                     /translation="MRIALAQIRSGTDPAANLQLVGKYAGEAATAGAQLVVFPEATMC
                     RLGVPLRQVAEPVDGPWANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPN
                     QPDAHYHKIHLYDAFGFTESRTVAPGREPVVVVVDGVRVGLTVCYDIRFPALYTELAR
                     RGAQLIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGDARTGVGASSAA
                     PTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAAARDRIAVLRNQTDFVQIDKA
                     QSRG"
     misc_feature    complement(569006..569800)
                     /locus_tag="Rv0480c"
                     /note="Uncharacterized subgroup of the nitrilase
                     superfamily (putative class 13 nitrilases); Region:
                     nitrilase_3; cd07581"
                     /db_xref="CDD:143605"
     misc_feature    complement(order(569294..569296,569357..569362,
                     569366..569371,569444..569446,569465..569467,
                     569477..569479,569687..569689))
                     /locus_tag="Rv0480c"
                     /note="putative active site [active]"
                     /db_xref="CDD:143605"
     misc_feature    complement(order(569369..569371,569477..569479,
                     569687..569689))
                     /locus_tag="Rv0480c"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143605"
     misc_feature    complement(order(569006..569017,569135..569140,
                     569231..569236,569240..569248,569252..569257,
                     569336..569341,569348..569362,569366..569368,
                     569420..569428,569447..569449,569465..569476))
                     /locus_tag="Rv0480c"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143605"
     gene            complement(569988..570512)
                     /locus_tag="Rv0481c"
                     /db_xref="GeneID:887161"
     CDS             complement(569988..570512)
                     /locus_tag="Rv0481c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:14532352]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_214995.1"
                     /db_xref="GeneID:887161"
                     /translation="MPRSFDMSADYEGSVEEVHRAFYEADYWKARLAETPVDVATLES
                     IRVGGDSGDDGTIEVVTLQMVRSHNLPGLVTQLHRGDLSVRREETWGPVKEGIATASI
                     AGSIVDAPVNLWGTAVLSPIPESGGSRMTLQVTIQVRIPFIGGKLERLIGTQLSQLVT
                     IEQRFTTLWITNNV"
     misc_feature    complement(570003..570473)
                     /locus_tag="Rv0481c"
                     /note="Protein of unknown function (DUF2505); Region:
                     DUF2505; pfam10698"
                     /db_xref="CDD:313829"
     gene            570539..571648
                     /gene="murB"
                     /locus_tag="Rv0482"
                     /db_xref="GeneID:887169"
     CDS             570539..571648
                     /gene="murB"
                     /locus_tag="Rv0482"
                     /note="UDP-N-acetylmuramate dehydrogenase Cofactor: FAD."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylenolpyruvoylglucosamine reductase"
                     /protein_id="NP_214996.1"
                     /db_xref="GeneID:887169"
                     /translation="MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQ
                     VVAALRHLDSAAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGNLVRAEA
                     GAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLDRCT
                     GEVRWVSARDLRFGYRTSVLKHADGLAVPTVVLEVEFALDPSGRSAPLRYGELIAALN
                     ATSGERADPQAVREAVLALRARKGMVLDPTDHDTWSVGSFFTNPVVTQDVYERLAGDA
                     ATRKDGPVPHYPAPDGVKLAAGWLVERAGFGKGYPDAGAAPCRLSTKHALALTNRGGA
                     TAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML"
     misc_feature    570539..571645
                     /gene="murB"
                     /locus_tag="Rv0482"
                     /note="UDP-N-acetylenolpyruvoylglucosamine reductase;
                     Provisional; Region: murB; PRK13903"
                     /db_xref="CDD:237552"
     gene            571710..573065
                     /gene="lprQ"
                     /locus_tag="Rv0483"
                     /db_xref="GeneID:887167"
     CDS             571710..573065
                     /gene="lprQ"
                     /locus_tag="Rv0483"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein LprQ"
                     /protein_id="NP_214997.1"
                     /db_xref="GeneID:887167"
                     /translation="MVIRVLFRPVSLIPVNNSSTPQSQGPISRRLALTALGFGVLAPN
                     VLVACAGKVTKLAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSA
                     GKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKAVPVAGKFTTVAPVKTINA
                     GFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDEAQGARV
                     HWRPREYYPAGTTVDVDAKLYGLPFGDGAYGAQDMSLHFQIGRRQVVKAEVSSHRIQV
                     VTDAGVIMDFPCSYGEADLARNVTRNGIHVVTEKYSDFYMSNPAAGYSHIHERWAVRI
                     SNNGEFIHANPMSAGAQGNSNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSY
                     ADGDIWDWAVDWDTWVSMSALPPPAAKPAATQIPVTAPVTPSDAPTPSGTPTTTNGPG
                     G"
     misc_feature    571881..572171
                     /gene="lprQ"
                     /locus_tag="Rv0483"
                     /note="IgD-like repeat domain of mycobacterial
                     L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431"
                     /db_xref="CDD:240446"
     misc_feature    572073..572870
                     /gene="lprQ"
                     /locus_tag="Rv0483"
                     /note="Lipoprotein-anchoring transpeptidase ErfK/SrfK
                     [Cell wall/membrane/envelope biogenesis]; Region: ErfK;
                     COG1376"
                     /db_xref="CDD:224294"
     misc_feature    572184..572489
                     /gene="lprQ"
                     /locus_tag="Rv0483"
                     /note="IgD-like repeat domain of mycobacterial
                     L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432"
                     /db_xref="CDD:240447"
     gene            complement(573046..573801)
                     /locus_tag="Rv0484c"
                     /db_xref="GeneID:887158"
     CDS             complement(573046..573801)
                     /locus_tag="Rv0484c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="short-chain type oxidoreductase"
                     /protein_id="NP_214998.1"
                     /db_xref="GeneID:887158"
                     /translation="MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADR
                     ITALANQIGGTAIVADVTDDAAVEALARALSRVDVLVNNAGGAKGLQFVADADLEHWR
                     WMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALH
                     RTLRGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIG
                     FVATRPSHVNLDQIVIRPRDQASASRRATHPVR"
     misc_feature    complement(573079..573801)
                     /locus_tag="Rv0484c"
                     /note="NADP-dependent 3-hydroxy acid dehydrogenase YdfG
                     [Energy production and conversion]; Region: YdfG; COG4221"
                     /db_xref="CDD:226674"
     gene            573984..575300
                     /locus_tag="Rv0485"
                     /db_xref="GeneID:887170"
     CDS             573984..575300
                     /locus_tag="Rv0485"
                     /note="NAGC/XYLR repressor family"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="NP_214999.1"
                     /db_xref="GeneID:887170"
                     /translation="MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAAASVFR
                     AVRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAVSGAIGRPRVPVEV
                     NHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNAAGAALTSLADSADRYLQR
                     WRRRRALWVGVTLGGAVDSATGHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMA
                     GAELMLGMRRFAPSSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLG
                     GTGQLESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQQAKELL
                     AERARVLGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAFTAGSVLAPRDIRVT
                     VFGNRVQEAGAGIVSLSGLYADPLGALRRSGALDARLQDTAPEALA"
     misc_feature    574287..575243
                     /locus_tag="Rv0485"
                     /note="Sugar kinase of the NBD/HSP70 family, may contain
                     an N-terminal HTH domain [Transcription, Carbohydrate
                     transport and metabolism]; Region: NagC; COG1940"
                     /db_xref="CDD:224851"
     misc_feature    575033..575069
                     /locus_tag="Rv0485"
                     /note="mcr19, fragment of putative small regulatory RNA
                     (See DiChiara et al., 2010), cloned from M. bovis
                     BCG~Pasteur; ends not mapped, 66-82 nt band detected by
                     Northern blot in M. bovis BCG Pasteur."
     gene            575348..576790
                     /gene="mshA"
                     /locus_tag="Rv0486"
                     /db_xref="GeneID:887160"
     CDS             575348..576790
                     /gene="mshA"
                     /locus_tag="Rv0486"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:12754249]"
                     /inference="protein motif:PROSITE:PS00039"
                     /note="glycosyltransferase MshA"
                     /codon_start=1
                     /transl_table=11
                     /product="D-inositol 3-phosphate glycosyltransferase"
                     /protein_id="NP_215000.1"
                     /db_xref="GeneID:887160"
                     /translation="MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDP
                     RRVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVR
                     VAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQ
                     VGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTD
                     DEARQVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQP
                     LKAPDIVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHT
                     DLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSG
                     HEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNA
                     ERQRRGGEVISDLVAVGKPRHWTPRRGVGA"
     misc_feature    575486..576688
                     /gene="mshA"
                     /locus_tag="Rv0486"
                     /note="D-inositol-3-phosphate glycosyltransferase; Region:
                     mycothiol_MshA; TIGR03449"
                     /db_xref="CDD:132490"
     gene            576787..577338
                     /locus_tag="Rv0487"
                     /db_xref="GeneID:887162"
     CDS             576787..577338
                     /locus_tag="Rv0487"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215001.1"
                     /db_xref="GeneID:887162"
                     /translation="MTSSLPTVQRVIQNALEVSQLKYSQHPRPGGAPPALIVELPGER
                     KLKINTILSVGEHSVRVEAFVCRKPDENREDVYRFLLRRNRRLYGVAYTLDNVGDIYL
                     VGQMALSAVDADEVDRVLGQVLEVVDSDFNALLELGFRSSIQREWQWRLSRGESLQNL
                     QAFAHLRPTTMQSAQRDEKELGG"
     misc_feature    576817..577194
                     /locus_tag="Rv0487"
                     /note="Putative bacterial sensory transduction regulator;
                     Region: YbjN; pfam10722"
                     /db_xref="CDD:313845"
     gene            577664..578269
                     /locus_tag="Rv0488"
                     /db_xref="GeneID:887171"
     CDS             577664..578269
                     /locus_tag="Rv0488"
                     /note="integral membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid transporter"
                     /protein_id="NP_215002.1"
                     /db_xref="GeneID:887171"
                     /translation="MMTLKVAIGPQNAFVLRQGIRREYVLVIVALCGIADGALIAAGV
                     GGFAALIHAHPNMTLVARFGGAAFLIGYALLAARNAWRPSGLVPSESGPAALIGVVQM
                     CLVVTFLNPHVYLDTVVLIGALANEESDLRWFFGAGAWAASVVWFAVLGFSAGRLQPF
                     FATPAAWRILDALVAVTMIGVAVVVLVTSPSVPTANVALII"
     misc_feature    577673..578197
                     /locus_tag="Rv0488"
                     /note="L-lysine exporter; Region: 2a75; TIGR00948"
                     /db_xref="CDD:130023"
     gene            578426..579175
                     /gene="gpm1"
                     /locus_tag="Rv0489"
                     /gene_synonym="gpm"
                     /db_xref="GeneID:887183"
     CDS             578426..579175
                     /gene="gpm1"
                     /locus_tag="Rv0489"
                     /gene_synonym="gpm"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00175"
                     /note="phosphoglyceromutase (PGAM) (BPG-dependent PGAM)"
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-bisphosphoglycerate-dependent
                     phosphoglycerate mutase"
                     /protein_id="YP_177731.1"
                     /db_xref="GeneID:887183"
                     /translation="MANTGSLVLLRHGESDWNALNLFTGWVDVGLTDKGQAEAVRSGE
                     LIAEHDLLPDVLYTSLLRRAITTAHLALDSADRLWIPVRRSWRLNERHYGALQGLDKA
                     ETKARYGEEQFMAWRRSYDTPPPPIERGSQFSQDADPRYADIGGGPLTECLADVVARF
                     LPYFTDVIVGDLRVGKTVLIVAHGNSLRALVKHLDQMSDDEIVGLNIPTGIPLRYDLD
                     SAMRPLVRGGTYLDPEAAAAGAAAVAGQGRG"
     misc_feature    578426..579127
                     /gene="gpm1"
                     /locus_tag="Rv0489"
                     /gene_synonym="gpm"
                     /note="phosphoglyceromutase; Provisional; Region: gpmA;
                     PRK14120"
                     /db_xref="CDD:184519"
     misc_feature    order(578456..578461,578612..578614,578972..578977)
                     /gene="gpm1"
                     /locus_tag="Rv0489"
                     /gene_synonym="gpm"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     gene            579349..580581
                     /gene="senX3"
                     /locus_tag="Rv0490"
                     /db_xref="GeneID:887185"
     CDS             579349..580581
                     /gene="senX3"
                     /locus_tag="Rv0490"
                     /experiment="DESCRIPTION:Gene expression[PMID:11101667]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="two component sensor histidine kinase SenX3"
                     /protein_id="NP_215004.1"
                     /db_xref="GeneID:887185"
                     /translation="MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWS
                     GITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQAL
                     GGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRD
                     FVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELS
                     RLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTA
                     LANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKA
                     RSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQA
                     REPELRSNRSQREEELSR"
     misc_feature    <579754..580467
                     /gene="senX3"
                     /locus_tag="Rv0490"
                     /note="Signal transduction histidine kinase [Signal
                     transduction mechanisms]; Region: BaeS; cl27674"
                     /db_xref="CDD:332495"
     repeat_region   580578..580654
                     /note="77 bp Mycobacterial Interspersed Repetitive
                     Unit,Class I (see Supply et al., 1997)"
     repeat_region   580655..580731
                     /note="77 bp Mycobacterial Interspersed Repetitive
                     Unit,Class I (see Supply et al., 1997)"
     repeat_region   580732..580808
                     /note="77 bp Mycobacterial Interspersed Repetitive
                     Unit,Class I (see Supply et al., 1997)"
     gene            580809..581492
                     /gene="regX3"
                     /locus_tag="Rv0491"
                     /db_xref="GeneID:887195"
     CDS             580809..581492
                     /gene="regX3"
                     /locus_tag="Rv0491"
                     /experiment="DESCRIPTION:Gene expression[PMID:11101667]"
                     /note="response regulator protein (sensory transduction
                     protein)"
                     /codon_start=1
                     /transl_table=11
                     /product="two component sensory transduction protein RegX"
                     /protein_id="NP_215005.1"
                     /db_xref="GeneID:887195"
                     /translation="MTSVLIVEDEESLADPLAFLLRKEGFEATVVTDGPAALAEFDRA
                     GADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKP
                     YSARELIARIRAVLRRGGDDDSEMSDGVLESGPVRMDVERHVVSVNGDTITLPLKEFD
                     LLEYLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTV
                     RGLGYKLEG"
     misc_feature    580818..581486
                     /gene="regX3"
                     /locus_tag="Rv0491"
                     /note="DNA-binding response regulator, OmpR family,
                     contains REC and winged-helix (wHTH) domain [Signal
                     transduction mechanisms, Transcription]; Region: OmpR;
                     COG0745"
                     /db_xref="CDD:223816"
     gene            complement(581489..583378)
                     /locus_tag="Rv0492c"
                     /db_xref="GeneID:887199"
     CDS             complement(581489..583378)
                     /locus_tag="Rv0492c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00198"
                     /inference="protein motif:PROSITE:PS00624"
                     /codon_start=1
                     /transl_table=11
                     /product="GMC-type oxidoreductase"
                     /protein_id="NP_215006.2"
                     /db_xref="GeneID:887199"
                     /translation="MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRL
                     PATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGLKA
                     IVLLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAM
                     VARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMG
                     RAVGGTTVVNSGTCFRPSLAVQRRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLE
                     IMGRNGRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACA
                     AGARIISWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSG
                     LGGHPRLGHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESDGVLIEATSTPPG
                     MGSMVFPGYGAELLRWLDRAPQIATFGAMVADRGVGTVRSVRGETVVRYDIAPGEIAK
                     LRVALQAIGRLLFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAAFHPTGT
                     AAAGADEQLCPVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAK
                     VVGVR"
     misc_feature    complement(581519..582961)
                     /locus_tag="Rv0492c"
                     /note="Choline dehydrogenase or related flavoprotein
                     [Lipid transport and metabolism, General function
                     prediction only]; Region: BetA; COG2303"
                     /db_xref="CDD:225186"
     misc_feature    complement(582155..582796)
                     /locus_tag="Rv0492c"
                     /note="GMC oxidoreductase; Region: GMC_oxred_N; pfam00732"
                     /db_xref="CDD:307054"
     gene            complement(583375..583704)
                     /locus_tag="Rv0492A"
                     /db_xref="GeneID:3205069"
     CDS             complement(583375..583704)
                     /locus_tag="Rv0492A"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_177623.1"
                     /db_xref="GeneID:3205069"
                     /translation="MSFLLDPPLLFVCGVLIERRLPVDRRDAAEAAALGVFFGASFGL
                     YHNVPGLGMLWRPFRAQNGRDFMWNSGVFSVDVARAEWPLHAMAAAIFATYPFFIKLG
                     RRLGRRI"
     gene            complement(583701..584690)
                     /locus_tag="Rv0493c"
                     /db_xref="GeneID:887200"
     CDS             complement(583701..584690)
                     /locus_tag="Rv0493c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215007.1"
                     /db_xref="GeneID:887200"
                     /translation="MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPL
                     TRTGLWVHCETVAPTTGGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGV
                     RMAPAELTGRTRSLAWELSWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLA
                     VGETTHRVDSWRGSVAHIYGHGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPL
                     AFVRFRIDGKDWPASPLPSLRMRTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGY
                     TDPDGAKAVCTNTEQADIHIELGGRHWSVLGTGHAEVGLRGTAAPAIKEGTPA"
     gene            584695..585423
                     /locus_tag="Rv0494"
                     /db_xref="GeneID:887166"
     CDS             584695..585423
                     /locus_tag="Rv0494"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00043"
                     /codon_start=1
                     /transl_table=11
                     /product="HTH-type transcriptional regulator"
                     /protein_id="NP_215008.2"
                     /db_xref="GeneID:887166"
                     /translation="MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPP
                     ERDLAERLGVNRTSLRQGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKLG
                     PDFLVELLEIRAALGPLIGRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYF
                     RVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAA
                     AAATVEAYLNASALRMVKSYRDRA"
     misc_feature    584722..585420
                     /locus_tag="Rv0494"
                     /note="DNA-binding transcriptional regulator, FadR family
                     [Transcription]; Region: FadR; COG2186"
                     /db_xref="CDD:225097"
     gene            complement(585424..586314)
                     /locus_tag="Rv0495c"
                     /db_xref="GeneID:887198"
     CDS             complement(585424..586314)
                     /locus_tag="Rv0495c"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215009.1"
                     /db_xref="GeneID:887198"
                     /translation="MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPG
                     QEVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCS
                     HGAFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGA
                     CIFLNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILK
                     TTLTEYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAM
                     CKRRSQLGLIAVHPATRAAQ"
     gene            586394..587380
                     /locus_tag="Rv0496"
                     /db_xref="GeneID:887234"
     CDS             586394..587380
                     /locus_tag="Rv0496"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215010.3"
                     /db_xref="GeneID:887234"
                     /translation="MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTI
                     DEFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFL
                     AVRRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGR
                     RRVAMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRT
                     LTANGLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICP
                     WALREGLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP"
     misc_feature    586397..587266
                     /locus_tag="Rv0496"
                     /note="Ppx/GppA phosphatase family; Region: Ppx-GppA;
                     pfam02541"
                     /db_xref="CDD:280671"
     gene            587377..588309
                     /locus_tag="Rv0497"
                     /db_xref="GeneID:887240"
     CDS             587377..588309
                     /locus_tag="Rv0497"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_215011.1"
                     /db_xref="GeneID:887240"
                     /translation="MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDA
                     ITVAELTGEIPIIRDDHHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEP
                     TRTVYWSQPEPRWPKSPPQDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDP
                     VEHYPDLWVDVLDTEVGEAEAETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVAR
                     RALDVVPTLWRGALVVLQSILAVAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVS
                     VRAVRKTEDIASTLIAVAVGALITLGPLALLQSG"
     misc_feature    587596..>587961
                     /locus_tag="Rv0497"
                     /note="chromosomal replication initiation protein;
                     Provisional; Region: dnaA; cl28271"
                     /db_xref="CDD:333091"
     misc_feature    <588055..588306
                     /locus_tag="Rv0497"
                     /note="ABC-2 family transporter protein; Region:
                     ABC2_membrane_3; cl26323"
                     /db_xref="CDD:331144"
     gene            588325..589167
                     /locus_tag="Rv0498"
                     /db_xref="GeneID:887238"
     CDS             588325..589167
                     /locus_tag="Rv0498"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215012.1"
                     /db_xref="GeneID:887238"
                     /translation="MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVS
                     QDIDAVRKLSRRYRVPVLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVH
                     PPFRWQRRYAEGFSDQVAALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGP
                     GPAISAFAPSYDPLDGNHAHYTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLP
                     ADEHLVPGRGTQPTAEVCQMLAGSGFVGHVVLEVSTSSARSANERESMLAESLQFART
                     HLLR"
     misc_feature    588331..589164
                     /locus_tag="Rv0498"
                     /note="Sugar phosphate isomerase/epimerase [Carbohydrate
                     transport and metabolism]; Region: YcjR; COG1082"
                     /db_xref="CDD:224007"
     gene            589183..590058
                     /locus_tag="Rv0499"
                     /db_xref="GeneID:887243"
     CDS             589183..590058
                     /locus_tag="Rv0499"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215013.1"
                     /db_xref="GeneID:887243"
                     /translation="MNALFTTAMALRPLDSDPGNPACRVFEGELNEHWTIGPKVHGGA
                     MVALCANAARTAYGAAGQQPMRQPVAVSASFLWAPDPGTMRLVTSIRKRGRRISVADV
                     ELTQGGRTAVHAVVTLGEPEHFLPGVDGSGGASGTAPLLSANPVVELMAPEPPEGVVP
                     IGPGHQLAGLVHLGEGCDVRPVLSTLRSATDGRPPVIQLWARPRGVAPDALFALLCGD
                     LSAPVTFAVDRTGWAPTVALTAYLRALPADGWLRVLCTCVEIGQDWFDEDHIVVDRLG
                     RIVVQTRQLAMVPAQ"
     misc_feature    589270..590046
                     /locus_tag="Rv0499"
                     /note="Thioesterase-like superfamily; Region: 4HBT_3;
                     pfam13622"
                     /db_xref="CDD:316172"
     gene            590083..590970
                     /gene="proC"
                     /locus_tag="Rv0500"
                     /db_xref="GeneID:887256"
     CDS             590083..590970
                     /gene="proC"
                     /locus_tag="Rv0500"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="NP_215014.1"
                     /db_xref="GeneID:887256"
                     /translation="MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRA
                     NYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVT
                     VVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
                     VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGS
                     AAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAV
                     DAAVQAAKSRSEQLRITPE"
     misc_feature    590134..590952
                     /gene="proC"
                     /locus_tag="Rv0500"
                     /note="pyrroline-5-carboxylate reductase; Reviewed;
                     Region: PRK11880"
                     /db_xref="CDD:237008"
     gene            591111..591347
                     /locus_tag="Rv0500A"
                     /db_xref="GeneID:3205035"
     CDS             591111..591347
                     /locus_tag="Rv0500A"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="YP_177624.1"
                     /db_xref="GeneID:3205035"
                     /translation="MTSTNGPSARDTGFVEGQQAKTQLLTVAEVAALMRVSKMTVYRL
                     VHNGELPAVRVGRSFRVHAKAVHDMLETSYFDAG"
     misc_feature    591180..591326
                     /locus_tag="Rv0500A"
                     /note="DNA binding domain, excisionase family; Region:
                     excise; TIGR01764"
                     /db_xref="CDD:200128"
     gene            591654..592784
                     /gene="galE2"
                     /locus_tag="Rv0501"
                     /gene_synonym="galE1"
                     /db_xref="GeneID:887228"
     CDS             591654..592784
                     /gene="galE2"
                     /locus_tag="Rv0501"
                     /gene_synonym="galE1"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="galactowaldenase (UDP-galactose 4-epimerase)
                     (uridine diphosphate galactose 4-epimerase) (uridine
                     diphospho-galactose 4-epimerase) Cofactor: NAD"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="NP_215050.2"
                     /db_xref="GeneID:887228"
                     /translation="MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLA
                     QNPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAAS
                     YAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDS
                     SSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPL
                     VPTIFGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVP
                     VPGFGVWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDD
                     YFRGRGLTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR"
     misc_feature    591729..592670
                     /gene="galE2"
                     /locus_tag="Rv0501"
                     /gene_synonym="galE1"
                     /note="UDP-glucose 4 epimerase (G4E), subgroup 3, extended
                     (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240"
                     /db_xref="CDD:187551"
     misc_feature    order(591741..591743,591747..591758,591825..591833,
                     591945..591953,591999..592001,592071..592079,
                     592161..592163,592173..592175,592245..592256)
                     /gene="galE2"
                     /locus_tag="Rv0501"
                     /gene_synonym="galE1"
                     /note="putative NAD(P) binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187551"
     misc_feature    order(592002..592004,592077..592079,592161..592163,
                     592173..592175)
                     /gene="galE2"
                     /locus_tag="Rv0501"
                     /gene_synonym="galE1"
                     /note="active site"
                     /db_xref="CDD:187551"
     misc_feature    order(592077..592079,592161..592163,592251..592253,
                     592305..592307,592332..592334)
                     /gene="galE2"
                     /locus_tag="Rv0501"
                     /gene_synonym="galE1"
                     /note="putative substrate binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187551"
     gene            592791..593867
                     /locus_tag="Rv0502"
                     /db_xref="GeneID:887260"
     CDS             592791..593867
                     /locus_tag="Rv0502"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215016.1"
                     /db_xref="GeneID:887260"
                     /translation="MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDP
                     NDRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSV
                     DEFGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLM
                     LSVAVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAV
                     FPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLL
                     ARLFGLPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELT
                     DQVRETIQQTLYRLLAGRRNIFFG"
     misc_feature    593160..593819
                     /locus_tag="Rv0502"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    order(593238..593240,593250..593252,593259..593261,
                     593310..593321,593454..593462)
                     /locus_tag="Rv0502"
                     /note="putative acyl-acceptor binding pocket; other site"
                     /db_xref="CDD:153249"
     gene            complement(593871..594779)
                     /gene="cmaA2"
                     /locus_tag="Rv0503c"
                     /gene_synonym="cma2"
                     /db_xref="GeneID:887264"
     CDS             complement(593871..594779)
                     /gene="cmaA2"
                     /locus_tag="Rv0503c"
                     /gene_synonym="cma2"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="DESCRIPTION:Mutation analysis[PMID:11092877]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="cyclopropane fatty acid synthase (CFA synthase)
                     (cyclopropane mycolic acid synthase 2) (mycolic acid
                     trans-cyclopropane synthetase)"
                     /codon_start=1
                     /transl_table=11
                     /product="cyclopropane mycolic acid synthase"
                     /protein_id="NP_215017.1"
                     /db_xref="GeneID:887264"
                     /translation="MTSQGDTTSGTQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCA
                     YFERPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVNVIGLT
                     LSENQYAHDKAMFDEVDSPRRKEVRIQGWEEFDEPVDRIVSLGAFEHFADGAGDAGFE
                     RYDTFFKKFYNLTPDDGRMLLHTITIPDKEEAQELGLTSPMSLLRFIKFILTEIFPGG
                     RLPRISQVDYYSSNAGWKVERYHRIGANYVPTLNAWADALQAHKDEAIALKGQETYDI
                     YMHYLRGCSDLFRDKYTDVCQFTLVK"
     misc_feature    complement(593886..594746)
                     /gene="cmaA2"
                     /locus_tag="Rv0503c"
                     /gene_synonym="cma2"
                     /note="Mycolic acid cyclopropane synthetase; Region: CMAS;
                     pfam02353"
                     /db_xref="CDD:280508"
     gene            complement(594802..595302)
                     /locus_tag="Rv0504c"
                     /db_xref="GeneID:887268"
     CDS             complement(594802..595302)
                     /locus_tag="Rv0504c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215018.1"
                     /db_xref="GeneID:887268"
                     /translation="MTVPEEAQTLIGKHYRAPDHFLVGREKIREFAVAVKDDHPTHYS
                     EPDAAAAGYPALVAPLTFLAIAGRRVQLEIFTKFNIPINIARVFHRDQKFRFHRPILA
                     NDKLYFDTYLDSVIESHGTVLAEIRSEVTDAEGKPVVTSVVTMLGEAAHHEADADATV
                     AAIASI"
     misc_feature    complement(594862..595281)
                     /locus_tag="Rv0504c"
                     /note="The hotdog fold was initially identified in the E.
                     coli FabA (beta-hydroxydecanoyl-acyl carrier protein
                     (ACP)-dehydratase) structure and subsequently in 4HBT
                     (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A
                     number of other seemingly unrelated...; Region: hot_dog;
                     cl00509"
                     /db_xref="CDD:321012"
     misc_feature    complement(order(595120..595125,595132..595134,
                     595177..595179,595186..595188,595192..595194,
                     595207..595209))
                     /locus_tag="Rv0504c"
                     /note="active site"
                     /db_xref="CDD:239525"
     misc_feature    complement(order(595123..595125,595177..595179,
                     595186..595188,595192..595194))
                     /locus_tag="Rv0504c"
                     /note="catalytic site [active]"
                     /db_xref="CDD:239525"
     gene            complement(595464..596585)
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /db_xref="GeneID:887270"
     CDS             complement(595464..596585)
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="PSP (O-phosphoserine phosphohydrolase) (pspase)"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoserine phosphatase SerB"
                     /protein_id="YP_177732.1"
                     /db_xref="GeneID:887270"
                     /translation="MGLTCWPRTAAGRVHDESRCGLANFDTALGLQINPRQPRAPPRI
                     CRIGLITAAASATGQAPRLGVMMVSSHLGSPDQAGHVDLASPADPPPPDASASHSPVD
                     MPAPVAAAGSDRQPPIDLTAAAFFDVDNTLVQGSSAVHFGRGLAARHYFTYRDVLGFL
                     YAQAKFQLLGKENSNDVAAGRRKALAFIEGRSVAELVALGEEIYDEIIADKIWDGTRE
                     LTQMHLDAGQQVWLITATPYELAATIARRLGLTGALGTVAESVDGIFTGRLVGEILHG
                     TGKAHAVRSLAIREGLNLKRCTAYSDSYNDVPMLSLVGTAVAINPDARLRSLARERGW
                     EIRDFRIARKAARIGVPSALALGAAGGALAALASRRQSR"
     misc_feature    complement(595611..596219)
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /note="Haloacid Dehalogenase-like Hydrolases; Region:
                     HAD_like; cl21460"
                     /db_xref="CDD:328728"
     misc_feature    complement(order(595668..595673,595680..595685,
                     595749..595751,595881..595886,596193..596207))
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /note="active site"
                     /db_xref="CDD:319796"
     misc_feature    complement(596193..596207)
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /note="HAD signature motif I; other site"
                     /db_xref="CDD:319796"
     misc_feature    complement(595884..595886)
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /note="HAD signature motif II; other site"
                     /db_xref="CDD:319796"
     misc_feature    complement(595749..595751)
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /note="HAD signature motif III; other site"
                     /db_xref="CDD:319796"
     misc_feature    complement(order(595668..595670,595680..595685))
                     /gene="serB1"
                     /locus_tag="Rv0505c"
                     /gene_synonym="serB"
                     /note="HAD signature motif IV; other site"
                     /db_xref="CDD:319796"
     gene            596759..597202
                     /gene="mmpS2"
                     /locus_tag="Rv0506"
                     /db_xref="GeneID:887279"
     CDS             596759..597202
                     /gene="mmpS2"
                     /locus_tag="Rv0506"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein MmpS2"
                     /protein_id="NP_215020.1"
                     /db_xref="GeneID:887279"
                     /translation="MRMISVSGAVKRMWLLLAIVVVAVVGGLGIYRLHSIFGVHEQPT
                     VMVKPDFDVPLFNPKRVTYEVFGPAKTAKIAYLDPDARVHRLDSVSLPWSVTVETTLP
                     AVSVNLMAQSNADVISCRIIVNGAVKDERSETSPRALTSCQVSSG"
     misc_feature    596786..597196
                     /gene="mmpS2"
                     /locus_tag="Rv0506"
                     /note="Mycobacterium membrane protein; Region:
                     Mycobact_memb; pfam05423"
                     /db_xref="CDD:283157"
     gene            597199..600105
                     /gene="mmpL2"
                     /locus_tag="Rv0507"
                     /db_xref="GeneID:887248"
     CDS             597199..600105
                     /gene="mmpL2"
                     /locus_tag="Rv0507"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane transport protein MmpL2"
                     /protein_id="NP_215021.1"
                     /db_xref="GeneID:887248"
                     /translation="MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFTAFVNLAVPQL
                     EVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSD
                     LMRKLSADTRHVAHIQDFWGDPLTAAGSQSADDRAAYVVVYLVGNNETEAYDSVHAVR
                     HMVDTTPPPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVIT
                     AVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGRYH
                     ESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFETLGAPIAIGML
                     VAVLAALTLGPAVLTVGSFFKLFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASI
                     GLLALPSYRTTYDLRKFMPASMPSNVGDAAAGRRFSRARLNPEVLLIETDHDMRNPVD
                     MLVLDKVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRI
                     DDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDF
                     FRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQMR
                     AQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQIDDSFYLPQ
                     SAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGISRVEPIKREAREAIKGTPL
                     QGAAIYLGGTAATFKDIREGARYDLLIAGVAAISLILIIMMIITRSVVAAVVIVGTVV
                     LSMGASFGLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYNLLLISRLKEEIGAGLN
                     TGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFM
                     TPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQHPSATGAHE"
     misc_feature    597241..600051
                     /gene="mmpL2"
                     /locus_tag="Rv0507"
                     /note="Uncharacterized membrane protein YdfJ, MMPL/SSD
                     domain [Function unknown]; Region: YdfJ; COG2409"
                     /db_xref="CDD:225272"
     gene            600098..600391
                     /locus_tag="Rv0508"
                     /db_xref="GeneID:887301"
     CDS             600098..600391
                     /locus_tag="Rv0508"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215022.1"
                     /db_xref="GeneID:887301"
                     /translation="MSRPQVELLTRAGCAICVRVAEQLAELSSELGFDMMTIDVDVAA
                     STGNPGLRAEFGDRLPVVLLDGREHSYWEVDEHRLRADIARSTFGSPPDKRLP"
     misc_feature    600113..600349
                     /locus_tag="Rv0508"
                     /note="Glutaredoxin-like domain (DUF836); Region: DUF836;
                     pfam05768"
                     /db_xref="CDD:283436"
     gene            600441..601847
                     /gene="hemA"
                     /locus_tag="Rv0509"
                     /db_xref="GeneID:887292"
     CDS             600441..601847
                     /gene="hemA"
                     /locus_tag="Rv0509"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00747"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamyl-tRNA reductase"
                     /protein_id="NP_215023.1"
                     /db_xref="GeneID:887292"
                     /translation="MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEA
                     MVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHLFA
                     VASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHELAQRALSVGKRVHSETAIDA
                     AGASVVSVALGMAERKLGSLAGTTAVVIGAGAMGALSAVHLTRAGVGHIQVLNRSLSR
                     AQRLARRIRESGVPAEALALDRLANVLADADVVVSCTGAVRPVVSLADVHHALAAARR
                     DEATRPLVICDLGMPRDVDPAVARLPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAA
                     EVASYLVGQRMAEVTPTVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRV
                     VDKLLHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVATAGELPVVPSGFDAE
                     SRRGGGDMQSSPKRSPSN"
     misc_feature    600447..601721
                     /gene="hemA"
                     /locus_tag="Rv0509"
                     /note="glutamyl-tRNA reductase; Region: hemA; TIGR01035"
                     /db_xref="CDD:273407"
     gene            601857..602786
                     /gene="hemC"
                     /locus_tag="Rv0510"
                     /db_xref="GeneID:887306"
     CDS             601857..602786
                     /gene="hemC"
                     /locus_tag="Rv0510"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:15525680]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="PBG (hydroxymethylbilane synthase) (HMBS)
                     (pre-uroporphyrinogen synthase) Cofactor: covalently binds
                     a dipyrromethane cofactor to which the porphobilinogen
                     subunits are added."
                     /codon_start=1
                     /transl_table=11
                     /product="porphobilinogen deaminase"
                     /protein_id="NP_215024.1"
                     /db_xref="GeneID:887306"
                     /translation="MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMA
                     PIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVA
                     RDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIV
                     VARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRA
                     AVTAERALLADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRAS
                     GIGSCGRARELGLSVAAELFELGARELMWGVRH"
     misc_feature    601857..602747
                     /gene="hemC"
                     /locus_tag="Rv0510"
                     /note="porphobilinogen deaminase; Reviewed; Region: hemC;
                     PRK00072"
                     /db_xref="CDD:234612"
     gene            602819..604516
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /db_xref="GeneID:887280"
     CDS             602819..604516
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="alternate gene name: cysG, uroporphyrinogen III
                     methylase (urogen III methylase) (SUMT) (urogen III
                     methylase) (UROM)"
                     /codon_start=1
                     /transl_table=11
                     /product="uroporphyrin-III C-methyltransferase"
                     /protein_id="YP_177733.1"
                     /db_xref="GeneID:887280"
                     /translation="MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPD
                     VPEPVVALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPAL
                     GDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASS
                     AVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQ
                     LAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIG
                     KTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRS
                     PAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTAD
                     RVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRER
                     GWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTII
                     ACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR"
     misc_feature    602837..603685
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /note="Uroporphyrinogen-III methylase (siroheme synthase)
                     [Coenzyme transport and metabolism]; Region: CysG;
                     COG0007"
                     /db_xref="CDD:223086"
     misc_feature    order(602873..602875,603197..603205,603212..603220,
                     603287..603292,603350..603352,603416..603421,
                     603500..603502,603506..603511,603590..603595)
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /note="active site"
                     /db_xref="CDD:212499"
     misc_feature    order(602873..602875,602891..602902,602906..602911,
                     603209..603214,603230..603232,603239..603244,
                     603269..603289,603293..603301,603305..603310,
                     603338..603346,603521..603523)
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212499"
     misc_feature    order(603197..603205,603212..603217,603287..603292,
                     603419..603421,603500..603502,603506..603511,
                     603590..603595)
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /note="SAM binding site [chemical binding]; other site"
                     /db_xref="CDD:212499"
     misc_feature    603701..604453
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /note="Uroporphyrinogen-III synthase [Coenzyme transport
                     and metabolism]; Region: HemD; COG1587"
                     /db_xref="CDD:224503"
     misc_feature    order(603722..603724,603887..603895,603983..603985,
                     604124..604126,604196..604198,604202..604204,
                     604277..604291)
                     /gene="hemD"
                     /locus_tag="Rv0511"
                     /gene_synonym="cysG"
                     /note="active site"
                     /db_xref="CDD:119440"
     gene            604602..605591
                     /gene="hemB"
                     /locus_tag="Rv0512"
                     /db_xref="GeneID:887312"
     CDS             604602..605591
                     /gene="hemB"
                     /locus_tag="Rv0512"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00169"
                     /note="porphobilinogen synthase (ALAD) (ALADH) Belongs to
                     the ALADH family. Cofactor: zinc."
                     /codon_start=1
                     /transl_table=11
                     /product="delta-aminolevulinic acid dehydratase"
                     /protein_id="NP_215026.1"
                     /db_xref="GeneID:887312"
                     /translation="MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGI
                     DEPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDG
                     ILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVA
                     QAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSS
                     LSGDRRTYQQEPGNAAEALREIELDLDEGADIVMVKPAMGYLDVVAAAADVSPVPVAA
                     YQVSGEYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYWAVDAAGWLT"
     misc_feature    604611..605585
                     /gene="hemB"
                     /locus_tag="Rv0512"
                     /note="delta-aminolevulinic acid dehydratase; Validated;
                     Region: PRK09283"
                     /db_xref="CDD:236450"
     misc_feature    order(604635..604637,604644..604649,604680..604682,
                     604752..604754,604761..604763,605040..605045,
                     605124..605129,605214..605222,605277..605279,
                     605286..605288,605304..605306,605313..605318,
                     605370..605384,605454..605456,605508..605510,
                     605520..605522,605529..605531)
                     /gene="hemB"
                     /locus_tag="Rv0512"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238226"
     misc_feature    order(604971..604973,604977..604979,604983..604985,
                     605007..605009,605115..605117,605205..605207,
                     605223..605225,605232..605237,605250..605252,
                     605268..605270,605280..605282,605361..605363,
                     605430..605432,605439..605441,605556..605558)
                     /gene="hemB"
                     /locus_tag="Rv0512"
                     /note="active site"
                     /db_xref="CDD:238226"
     misc_feature    order(605205..605207,605361..605363)
                     /gene="hemB"
                     /locus_tag="Rv0512"
                     /note="Schiff base residues; other site"
                     /db_xref="CDD:238226"
     gene            605604..606152
                     /locus_tag="Rv0513"
                     /db_xref="GeneID:887307"
     CDS             605604..606152
                     /locus_tag="Rv0513"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_215027.1"
                     /db_xref="GeneID:887307"
                     /translation="MTPTGDTKPKLLFYEPGASWYWVLTGPLAAVSVLLLEISSGAGV
                     GLITPAIFLVMVSAFVALQVKAARIHTSVELTHDALRQGTETIRLAEIVKIYPEADGR
                     ETSGEEPAKWQSARTLGELVGVPRGRVGIGLKLTGGRTAQAWARRHQQLRAALTPLVQ
                     ERLGPVDSDVADVNGDDAGPAR"
     gene            606149..606448
                     /locus_tag="Rv0514"
                     /db_xref="GeneID:887319"
     CDS             606149..606448
                     /locus_tag="Rv0514"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_215028.1"
                     /db_xref="GeneID:887319"
                     /translation="MIARYRAGAELFLACAALAGSAASWSRTRSTVAVAPVIDGQPVT
                     LSVVYHPQPLVLTLLLATIAGVLSVVGTARLRRARAGLNAHPDGLNQRPPGGWCH"
     gene            606551..608062
                     /locus_tag="Rv0515"
                     /db_xref="GeneID:887322"
     CDS             606551..608062
                     /locus_tag="Rv0515"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215029.1"
                     /db_xref="GeneID:887322"
                     /translation="MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAA
                     AQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRE
                     RLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLA
                     GQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSAL
                     AGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEA
                     ATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADF
                     VRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQ
                     QLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPK
                     RRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDHNDDPPPF"
     misc_feature    606650..607567
                     /locus_tag="Rv0515"
                     /note="Domain of unknown function (DUF222); Region:
                     DUF222; pfam02720"
                     /db_xref="CDD:308380"
     misc_feature    607562..607705
                     /locus_tag="Rv0515"
                     /note="HNH nucleases; HNH endonuclease signature which is
                     found in viral, prokaryotic, and eukaryotic proteins. The
                     alignment includes members of the large group of homing
                     endonucleases, yeast intron 1 protein, MutS, as well as
                     bacterial colicins, pyocins, and...; Region: HNHc;
                     cd00085"
                     /db_xref="CDD:238038"
     misc_feature    order(607613..607615,607619..607627,607631..607633,
                     607664..607669,607679..607684,607691..607693,
                     607703..607705)
                     /locus_tag="Rv0515"
                     /note="active site"
                     /db_xref="CDD:238038"
     gene            complement(608059..608535)
                     /locus_tag="Rv0516c"
                     /db_xref="GeneID:887324"
     CDS             complement(608059..608535)
                     /locus_tag="Rv0516c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="anti-anti-sigma factor"
                     /protein_id="NP_215030.1"
                     /db_xref="GeneID:887324"
                     /translation="MTTTIPTSKSACSVTTRPGNAAVDYGGAQIRAYLHHLATVVTIR
                     GEIDAANVEQISEHVRRFSLGTNPMVLDLSELSHFSGAGISLLCILDEDCRAAGVQWA
                     LVASPAVVEQLGGRCDQGEHESMFPMARSVHKALHDLADAIDRRRQLVLPLISRSA"
     misc_feature    complement(608131..608451)
                     /locus_tag="Rv0516c"
                     /note="STAS domain; Region: STAS; pfam01740"
                     /db_xref="CDD:307726"
     misc_feature    complement(order(608200..608202,608266..608271,
                     608278..608286,608290..608298,608302..608304,
                     608368..608370,608386..608394,608398..608400))
                     /locus_tag="Rv0516c"
                     /note="anti sigma factor interaction site; other site"
                     /db_xref="CDD:132914"
     misc_feature    complement(608293..608295)
                     /locus_tag="Rv0516c"
                     /note="regulatory phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:132914"
     gene            608746..610056
                     /locus_tag="Rv0517"
                     /db_xref="GeneID:887323"
     CDS             608746..610056
                     /locus_tag="Rv0517"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase"
                     /protein_id="NP_215031.1"
                     /db_xref="GeneID:887323"
                     /translation="MAGGMDQPPGQPRRRTRQQSSDGKNGVRAAEITGEIRALTGLRI
                     VAAVWVVLFHFRPMLGDASPGFRDALAPVLDCGAQGVDLFFILSGFVLTWNYLDRMGR
                     SWSVRANLHFLWLRLARVWPVYLVTLHLAAVWVIFTLHVGHVPSPEAGQLTAISYVRQ
                     ILLVQLWFQPYFDGSSWDGPAWSISAEWLAYLLFGLLILVIFRMKHATRARGLMWLAF
                     AASLPPVVLLLASGQFYTPWSWLPRIVTQFAAGALACAAVRRLRPTDRARRIAGYLSV
                     LVGVAIVGILYLLHAHPLAGVEDSGGVVDVLFVPLVISLAIGVGSLPALLSTRLMVFG
                     GQISFCLYMVHELVHTAWGWAVQQYELALQDQPWKWNVVGLLAIALGAAILLYHFVEE
                     PGRRWMRRMVDVKAASARSEPGEPVGSTRYQIDDALEGVSARAV"
     misc_feature    608851..609984
                     /locus_tag="Rv0517"
                     /note="Peptidoglycan/LPS O-acetylase OafA/YrhL, contains
                     acyltransferase and SGNH-hydrolase domains [Cell
                     wall/membrane/envelope biogenesis]; Region: OafA; COG1835"
                     /db_xref="CDD:224748"
     gene            610188..610883
                     /locus_tag="Rv0518"
                     /db_xref="GeneID:887321"
     CDS             610188..610883
                     /locus_tag="Rv0518"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215032.1"
                     /db_xref="GeneID:887321"
                     /translation="MSRPGTYVIGLTLLVGLVVGNPGCPRSYRPLTLDYRLNPVAVIG
                     DSYTTGTDEGGLGSKSWTARTWQMLAARGVRIAADVAAEGRAGYGVPGDHGNVFEDLT
                     ARAVQPDDALVVFFGSRNDQGMDPEDPEMLAEKVRDTFDLARHRAPSASLLVIAPPWP
                     TADVPGPMLRIRDVLGAQARAAGAVFVDPIADHWFVDRPELIGADGVHPNDAGHEYLA
                     DKIAPLISMELVG"
     misc_feature    610305..610859
                     /locus_tag="Rv0518"
                     /note="SGNH_hydrolase, or GDSL_hydrolase, is a diverse
                     family of lipases and esterases. The tertiary fold of the
                     enzyme is substantially different from that of the
                     alpha/beta hydrolase family and unique among all known
                     hydrolases; its active site closely...; Region:
                     SGNH_hydrolase; cd00229"
                     /db_xref="CDD:238141"
     misc_feature    order(610323..610325,610446..610448,610545..610547,
                     610800..610802,610809..610811)
                     /locus_tag="Rv0518"
                     /note="active site"
                     /db_xref="CDD:238141"
     misc_feature    order(610323..610325,610800..610802,610809..610811)
                     /locus_tag="Rv0518"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238141"
     misc_feature    order(610323..610325,610446..610448,610545..610547)
                     /locus_tag="Rv0518"
                     /note="oxyanion hole [active]"
                     /db_xref="CDD:238141"
     gene            complement(611172..612074)
                     /locus_tag="Rv0519c"
                     /db_xref="GeneID:887334"
     CDS             complement(611172..612074)
                     /locus_tag="Rv0519c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00120"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_215033.1"
                     /db_xref="GeneID:887334"
                     /translation="MLRRGCAGNTDRRGIMTPMADLTRRALLRWGAGAGAGAAGVWAF
                     GALVDPLEPQAAPAPFEPPTAGSSLPTRISGSFISAARGGIKTNWVISMPPGQSGQLR
                     PVIALHGKDGNAGMMLDLGVEQGLARLVKEGKPAFAVVGVDGGNTYWHRRSSGGDSGA
                     MVLDELLPMLTSMGMDTSRVGFLGWSMGGYGALLLGARLGPARTAGICAISPALFTSF
                     TGSTPGAFDSYDDYVQHSVLGLPALNSIPLRVDCGTSDRFYFATRQFVNQLHQPPAGS
                     FSPGGHDASYWREQLPGELAWMAS"
     misc_feature    complement(611181..612023)
                     /locus_tag="Rv0519c"
                     /note="Enterochelin esterase or related enzyme [Inorganic
                     ion transport and metabolism]; Region: Fes; cl28565"
                     /db_xref="CDD:333385"
     gene            613038..614342
                     /gene="gabP"
                     /locus_tag="Rv0522"
                     /db_xref="GeneID:886261"
     CDS             613038..614342
                     /gene="gabP"
                     /locus_tag="Rv0522"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /inference="protein motif:PROSITE:PS00218"
                     /note="4-amino butyrate transport carrier
                     (GAMA-aminobutyrate permease) Belongs to the amino acid
                     permease family (APC family)."
                     /codon_start=1
                     /transl_table=11
                     /product="GABA permease GabP"
                     /protein_id="YP_177734.1"
                     /db_xref="GeneID:886261"
                     /translation="MIAIGGVIGAGLFVGSGVVIRATGPAAFLTYALCGALIVLVMRM
                     LGEMAAANPSTGAFADYAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWID
                     APLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLVLGTAFAFGLLPGH
                     GMDFSNLSAHGGFFPDGVGAVFAAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMST
                     VVARIVIFFVGSVFLLTVILPWNSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLS
                     CLNSGLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSVVGFLCVIMAWVSPA
                     TVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQNLGVRMWLFPGLSIVTVTGIVAV
                     LARMAFDYAARSQLWLSLLSWAVVVGCYLVTTLVRRPLNRPW"
     misc_feature    613038..614324
                     /gene="gabP"
                     /locus_tag="Rv0522"
                     /note="L-asparagine transporter and related permeases
                     [Amino acid transport and metabolism]; Region: AnsP;
                     COG1113"
                     /db_xref="CDD:224038"
     gene            complement(614326..614721)
                     /locus_tag="Rv0523c"
                     /db_xref="GeneID:887341"
     CDS             complement(614326..614721)
                     /locus_tag="Rv0523c"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215037.1"
                     /db_xref="GeneID:887341"
                     /translation="MQLPQWLARFNRYVTNPIQRLWAGWLPAFAILEHVGRRSGKPYR
                     TPLNVFSADVDGRAGVAILLTYGPNRDWLKNITAAGGGRMRRYGKTFGVANPRRLTKA
                     EAAPYVSSRWRPVFARLPFDEAVLLTKAD"
     misc_feature    complement(614338..614664)
                     /locus_tag="Rv0523c"
                     /note="Pyridoxine 5'-phosphate (PNP) oxidase-like and
                     flavin reductase-like proteins; Region: PNPOx/FlaRed_like;
                     cl00381"
                     /db_xref="CDD:320943"
     gene            614835..616223
                     /gene="hemL"
                     /locus_tag="Rv0524"
                     /db_xref="GeneID:887349"
     CDS             614835..616223
                     /gene="hemL"
                     /locus_tag="Rv0524"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00600"
                     /note="GSA (glutamate-1-semialdehyde aminotransferase)
                     (GSA-at). Belongs to class-III of
                     pyridoxal-phosphate-dependent aminotransferases. Cofactor:
                     pyridoxal phosphate."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate-1-semialdehyde 2,1-aminomutase"
                     /protein_id="NP_215038.1"
                     /db_xref="GeneID:887349"
                     /translation="MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVG
                     GTPRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFGAP
                     TPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHV
                     DALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDA
                     VQQTFARFGEQIAAVITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFR
                     VSRSGWYGIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNP
                     VAVAAGLATLRAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAGNMLSVFFGE
                     TPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSAALDDAAFGRIANALP
                     AAARAAAQERPA"
     misc_feature    614883..616169
                     /gene="hemL"
                     /locus_tag="Rv0524"
                     /note="glutamate-1-semialdehyde aminotransferase;
                     Provisional; Region: PRK00062"
                     /db_xref="CDD:234607"
     gene            616223..616831
                     /locus_tag="Rv0525"
                     /db_xref="GeneID:887358"
     CDS             616223..616831
                     /locus_tag="Rv0525"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215039.1"
                     /db_xref="GeneID:887358"
                     /translation="MPEETQVHVVRHGEVHNPTGILYGRLPGFHLSATGAAQAAAVAD
                     ALADRDIVAVIASPLQRAQETAAPIAARHDLAVETDPDLIESANFFEGRRVGPGDGAW
                     RDPRVWWQLRNPFTPSWGEPYVDIAARMTTAVDKARVRGAGHEVVCVSHQLPVWTLRL
                     YLTGKRLWHDPRRRDCALASVTSLIYDGDRLVDVVYSQPAAL"
     misc_feature    616241..616798
                     /locus_tag="Rv0525"
                     /note="Histidine phosphatase superfamily (branch 1);
                     Region: His_Phos_1; pfam00300"
                     /db_xref="CDD:306748"
     misc_feature    order(616253..616258,616403..616405,616673..616678)
                     /locus_tag="Rv0525"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132716"
     repeat_region   616828..616878
                     /note="51 bp Mycobacterial Interspersed Repetitive
                     Unit,Class II"
     gene            616846..617496
                     /locus_tag="Rv0526"
                     /db_xref="GeneID:887339"
     CDS             616846..617496
                     /locus_tag="Rv0526"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00194"
                     /note="thiol-disulfide interchange protein"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="NP_215040.1"
                     /db_xref="GeneID:887339"
                     /translation="MQSRATRRSGALTMRRLVIAAAVSALLLTGCSGRDAVAQGGTFE
                     FVSPGGKTDIFYDPPASRGRPGPLSGPELADPARSVSLDDFPGQVVVVNVWGQWCGPC
                     RAEVSQLQRVYDATRGAGVSFLGIDVRDNNRQAPQDFINDRHVTYPSIYDPAMRTLIA
                     FGGKYPTSVIPSTLVLDRQHRVAAVFLRELLAADLQPVVERVAEEEPSGRAPVGAQ"
     misc_feature    617044..617406
                     /locus_tag="Rv0526"
                     /note="TlpA-like family; composed of TlpA, ResA, DsbE and
                     similar proteins. TlpA, ResA and DsbE are bacterial
                     protein disulfide reductases with important roles in
                     cytochrome maturation. They are membrane-anchored proteins
                     with a soluble TRX domain containing a...; Region:
                     TlpA_like_family; cd02966"
                     /db_xref="CDD:239264"
     misc_feature    order(617140..617142,617149..617151)
                     /locus_tag="Rv0526"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239264"
     gene            617493..618272
                     /gene="ccdA"
                     /locus_tag="Rv0527"
                     /gene_synonym="ccsA"
                     /db_xref="GeneID:887362"
     CDS             617493..618272
                     /gene="ccdA"
                     /locus_tag="Rv0527"
                     /gene_synonym="ccsA"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome C-type biogenesis protein CcdA"
                     /protein_id="YP_177735.1"
                     /db_xref="GeneID:887362"
                     /translation="MTGFTEIAAVGPLLVAVGVCLLAGLVSFASPCVVPLVPGYLSYL
                     AAVVGVDEQLPAGVVKPPVAARWRVAGSAALFVAGFTTVFVLGTVAVLGMTTTLITNQ
                     LLLQRVGGVLIVVMGLVFVGFIGALQRQARFTPRQLTSVAGAPVLGAVFALGWTPCLG
                     PTLTGVITVASATEGASVARGIVLVIAYCLGLGIPFVLLAFGSAWAVAGLGWLRRHTR
                     AIQIFGGALLIAVGAALVTGVWNDVVSWLRDAFVSDVRLPI"
     misc_feature    617532..618200
                     /gene="ccdA"
                     /locus_tag="Rv0527"
                     /gene_synonym="ccsA"
                     /note="Cytochrome c biogenesis protein CcdA [Energy
                     production and conversion, Posttranslational modification,
                     protein turnover, chaperones]; Region: CcdA; COG0785"
                     /db_xref="CDD:223856"
     gene            618305..619894
                     /locus_tag="Rv0528"
                     /db_xref="GeneID:887372"
     CDS             618305..619894
                     /locus_tag="Rv0528"
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_215042.1"
                     /db_xref="GeneID:887372"
                     /translation="MWRSLTSMGTALVLLFLLALAAIPGALLPQRGLNAAKVDDYLAA
                     HPLIGPWLDELQAFDVFSSFWFTAIYVLLFVSLVGCLAPRTIEHARSLRATPVAAPRN
                     LARLPKHAHARLAGEPAALAATITGRLRGWRSITRQQGDSVEVSAEKGYLREFGNLVF
                     HFALLGLLVAVAVGKLFGYEGNVIVIADGGPGFCSASPAAFDSFRAGNTVDGTSLHPI
                     CVRVNNFQAHYLPSGQATSFAADIDYQADPATADLIANSWRPYRLQVNHPLRVGGDRV
                     YLQGHGYAPTFTVTFPDGQTRTSTVQWRPDNPQTLLSAGVVRIDPPAGSYPNPDERRK
                     HQIAIQGLLAPTEQLDGTLLSSRFPALNAPAVAIDIYRGDTGLDSGRPQSLFTLDHRL
                     IEQGRLVKEKRVNLRAGQQVRIDQGPAAGTVVRFDGAVPFVNLQVSHDPGQSWVLVFA
                     ITMMAGLLVSLLVRRRRVWARITPTTAGTVNVELGGLTRTDNSGWGAEFERLTGRLLA
                     GFEARSPDMAEAAAGTGRDVD"
     misc_feature    618371..619891
                     /locus_tag="Rv0528"
                     /note="Cytochrome c biogenesis protein ResB [Energy
                     production and conversion, Posttranslational modification,
                     protein turnover, chaperones]; Region: ResB; COG1333"
                     /db_xref="CDD:224252"
     gene            619891..620865
                     /gene="ccsA"
                     /locus_tag="Rv0529"
                     /gene_synonym="ccsB"
                     /db_xref="GeneID:887380"
     CDS             619891..620865
                     /gene="ccsA"
                     /locus_tag="Rv0529"
                     /gene_synonym="ccsB"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome C-type biogenesis protein CcsA"
                     /protein_id="NP_215041.2"
                     /db_xref="GeneID:887380"
                     /translation="MNTLHVNVGLARYSDWAFTSAVVALVVALLLLAFEFAQVRGRGL
                     APLAVPAGSVATDSATPGIVADQRHRPFDERVGRGGLAVAYLGIGLLLACVVLRGLAT
                     QRVPWGNMYEFINLTCLSGLIAGAVVLRRARYRPLWVFLLVPVLILLTVSGRWLYANA
                     APVMPALQSYWLPIHVSVVSLGSGVFLVAGVASILFLVRTSRLGEPTGEGALAGMVRR
                     LPDAQTLDGIAYRTTIFAFPVFGFGVIFGAIWAEEAWGRYWGWDPKETVSFVAWVVYA
                     AYLHARSTAGWRDRKAAWINVAGFVAMVFNLFFVNLVTVGLHSYAGVG"
     misc_feature    620137..620853
                     /gene="ccsA"
                     /locus_tag="Rv0529"
                     /gene_synonym="ccsB"
                     /note="cytochrome c-type biogenesis protein CcsB; Region:
                     cytochr_II_ccsB; TIGR03144"
                     /db_xref="CDD:274447"
     gene            620907..622124
                     /locus_tag="Rv0530"
                     /db_xref="GeneID:887385"
     CDS             620907..622124
                     /locus_tag="Rv0530"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215044.1"
                     /db_xref="GeneID:887385"
                     /translation="MLVTEHPRTGVGAPDSGNGGTDHPTVQLPPVPSVGAPPAAAGGE
                     TPTRSVAGFRTQRLDPTAYGAYYSGPDEGPASPAERPPYRLEPVPHTPYPELATTTLL
                     RPVKPPPSEGWRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKG
                     GVGKTTITATLGATFADLRGDRVVAVDANPDRGTLSQKVPLETPATVRHLLRDADGIE
                     RYSDVRGYTSKGPSGLEVLASDSDPASSDAFSADDYTRTLDILERFYGLVLTDCGTGL
                     LHSAMSAVLPRSDVLVVVSSGSIDGARSAAATLDWLQAHGHDDQVRNSIAVVNAVRPR
                     AGKVDVGKVVEHFSRRCRAVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAG
                     FPGDPRRCKPSFT"
     misc_feature    621351..622103
                     /locus_tag="Rv0530"
                     /note="MinD-like ATPase involved in chromosome
                     partitioning or flagellar assembly [Cell cycle control,
                     cell division, chromosome partitioning, Cell motility];
                     Region: FlhG; COG0455"
                     /db_xref="CDD:223531"
     gene            complement(622121..622282)
                     /locus_tag="Rv0530A"
                     /db_xref="GeneID:14515848"
     CDS             complement(622121..622282)
                     /locus_tag="Rv0530A"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_007409181.1"
                     /db_xref="GeneID:14515848"
                     /translation="MLYLLLVLILATLIYLGWRAARAQMNRPKTRVIGPDDDPEFLRR
                     LGHGDNNRS"
     gene            622329..622646
                     /locus_tag="Rv0531"
                     /db_xref="GeneID:887376"
     CDS             622329..622646
                     /locus_tag="Rv0531"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_215045.1"
                     /db_xref="GeneID:887376"
                     /translation="MSEAPNDKTTRGVVDILVYATARLLLVVAVSAAIFGVARLIGLT
                     EFPVVVATLFGLIIAMPLGIWVFSPLRRRATAALAVAGERRRAERERLRARLRGESLP
                     EEQ"
     misc_feature    622377..622568
                     /locus_tag="Rv0531"
                     /note="Protein of unknown function (DUF4229); Region:
                     DUF4229; pfam14012"
                     /db_xref="CDD:316525"
     gene            622793..624577
                     /gene="PE_PGRS6"
                     /locus_tag="Rv0532"
                     /db_xref="GeneID:887391"
     CDS             622793..624577
                     /gene="PE_PGRS6"
                     /locus_tag="Rv0532"
                     /note="Member of the Mycobacterium tuberculosis PE family,
                     PGRS subfamily of gly-rich proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="PE-PGRS family protein PE_PGRS6"
                     /protein_id="YP_177736.1"
                     /db_xref="GeneID:887391"
                     /translation="MSNLLVTPELVAAAAADLAGIGSAIGAANAAAGAPTMALLAAGA
                     DEVSAAVAAVFSSYAQQYQALSAAAAAFHDQFVRALAAGAGAYAGAEAANVEQQLLNA
                     INAPTLALLGRPLIGNGADGAAGTGQAGGAGGLLYGNGGNGGSGAAGQAGGAGGAAGL
                     IGHGGTGGAVTGVSTTGGPGGHGGDAGLYGFGGAGGAGGFGQSGAAGGAGGAGGWLYG
                     DGGDGGAGDNGGNESGTGVSAVGGVGGAGGAGGLLFGNGGDGGVGGDGGDGSSTQDSG
                     GDGGAGGAGGAGGWLLGNGGAGGAGGAASIKVATGGLGGDGGDAGLFGFGGDGGWGGR
                     GVDARFGAAGGAAGAGGAGGWLYGDGGAGGVGGVGGAVFSLSSGDGGAGGAGGGGGWL
                     FGNGGDGGAGGGGGGRFGSGSGAGGDGAVGGAGGAGAWFGNGGAGGVGGGGGRGTTAI
                     GGDGGAGGAGGAGGWLYGDGGAGGAGGGGGRGGTGNDGGDGGDGGRGGDAQLLGNGGD
                     GGAGGAGGPAGLALPPGPARPAGAAVPAVRCSAAPARPARTADPWLAPIFARSTLRHS
                     HHLGGIAQTGAVADQQGQIAGLGRAGRQ"
     misc_feature    622793..623026
                     /gene="PE_PGRS6"
                     /locus_tag="Rv0532"
                     /note="PE family; Region: PE; pfam00934"
                     /db_xref="CDD:279302"
     gene            complement(624473..625480)
                     /gene="fabH"
                     /locus_tag="Rv0533c"
                     /gene_synonym="mtFabH"
                     /db_xref="GeneID:887381"
     CDS             complement(624473..625480)
                     /gene="fabH"
                     /locus_tag="Rv0533c"
                     /gene_synonym="mtFabH"
                     /experiment="DESCRIPTION:Gene expression, protein
                     characterization[PMID:10840036]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="beta-ketoacyl-ACP synthase III (KAS III)"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP synthase III"
                     /protein_id="NP_215047.1"
                     /db_xref="GeneID:887381"
                     /translation="MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIY
                     TRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAP
                     MVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYD
                     RGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPF
                     VRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRP
                     DAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPK
                     G"
     misc_feature    complement(624485..625450)
                     /gene="fabH"
                     /locus_tag="Rv0533c"
                     /gene_synonym="mtFabH"
                     /note="3-oxoacyl-[acyl-carrier-protein] synthase III
                     [Lipid transport and metabolism]; Region: FabH; cl28397"
                     /db_xref="CDD:333217"
     gene            complement(625562..626440)
                     /gene="menA"
                     /locus_tag="Rv0534c"
                     /db_xref="GeneID:887408"
     CDS             complement(625562..626440)
                     /gene="menA"
                     /locus_tag="Rv0534c"
                     /note="DHNA-octaprenyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="1,4-dihydroxy-2-naphthoate
                     octaprenyltransferase"
                     /protein_id="NP_215048.1"
                     /db_xref="GeneID:887408"
                     /translation="MASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLA
                     LAVAVALVIGVNYANDYSDGIRGTDDDRVGPVRLVGSRLATPRSVLTAAMTSLALGAL
                     AGLVLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQY
                     TQALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQ
                     GLLAVAGVLTFVLMLATPWCVVGLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAML
                     VWALAVAGALAFGQLS"
     misc_feature    complement(625586..626407)
                     /gene="menA"
                     /locus_tag="Rv0534c"
                     /note="1,4-dihydroxy-2-naphthoate octaprenyltransferase;
                     Region: menA; TIGR00751"
                     /db_xref="CDD:129834"
     misc_feature    complement(order(625853..625855,625865..625867,
                     625874..625879,626252..626254,626261..626266))
                     /gene="menA"
                     /locus_tag="Rv0534c"
                     /note="putative active site [active]"
                     /db_xref="CDD:260125"
     gene            626457..627251
                     /locus_tag="Rv0535"
                     /db_xref="GeneID:887430"
     CDS             626457..627251
                     /locus_tag="Rv0535"
                     /experiment="DESCRIPTION:Protein purification and
                     characterization[PMID:22225784]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="MTA phosphorylase. Belongs to the PNP/MTAP family 2
                     of phosphorylases"
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine phosphorylase"
                     /protein_id="NP_215049.1"
                     /db_xref="GeneID:887430"
                     /translation="MHNNGRMLGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGT
                     IGVHDVAFLPRHGAHHQYSAHAVPYRANMWALRALGVRRVFGPCAVGSLDPELEPGAV
                     VVPDQLVDRTSGRADTYFDFGGVHAAFADPYCPTLRAAVTGLPGVVDGGTMVVIQGPR
                     FSTRAESQWFAAAGCNLVNMTGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAA
                     DVFAAFGENIELLKRLVRAAIDRVADERTCTHCQHHAGVPLPFELP"
     misc_feature    626457..627248
                     /locus_tag="Rv0535"
                     /note="5'-methylthioadenosine phosphorylase; Validated;
                     Region: PRK07823"
                     /db_xref="CDD:236107"
     gene            627248..628288
                     /gene="galE3"
                     /locus_tag="Rv0536"
                     /gene_synonym="galE2"
                     /db_xref="GeneID:887457"
     CDS             627248..628288
                     /gene="galE3"
                     /locus_tag="Rv0536"
                     /gene_synonym="galE2"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="galactowaldenase (UDP-galactose 4-epimerase)
                     (uridine diphosphate galactose 4-epimerase) (uridine
                     diphospho-galactose 4-epimerase)"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="YP_177737.1"
                     /db_xref="GeneID:887457"
                     /translation="MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHGPNPVL
                     PPGCQRVDVRDASALAPLLAGVDLVCHQAAMVGAGVNAADAPAYGGHNDFATTVLLAQ
                     MFAAGVRRLVLASSMVVYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVI
                     WQLVDEDAPLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMPRDTPYS
                     GVAAIFRSAVEKGKPPKVFEDGGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVC
                     SGRPISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLGFRAAVDPG
                     EGLREFAFAPLR"
     misc_feature    627251..628267
                     /gene="galE3"
                     /locus_tag="Rv0536"
                     /gene_synonym="galE2"
                     /note="Short-chain dehydrogenases/reductases (SDR);
                     Region: SDR; cl25409"
                     /db_xref="CDD:330230"
     misc_feature    order(627266..627268,627272..627277,627281..627283,
                     627338..627346,627461..627469,627587..627595,
                     627773..627775,627785..627787,627854..627865)
                     /gene="galE3"
                     /locus_tag="Rv0536"
                     /gene_synonym="galE2"
                     /note="NAD(P) binding site [chemical binding]; other site"
                     /db_xref="CDD:187535"
     misc_feature    order(627521..627523,627593..627595,627773..627775,
                     627785..627787)
                     /gene="galE3"
                     /locus_tag="Rv0536"
                     /gene_synonym="galE2"
                     /note="active site"
                     /db_xref="CDD:187535"
     gene            complement(628298..629731)
                     /locus_tag="Rv0537c"
                     /db_xref="GeneID:887465"
     CDS             complement(628298..629731)
                     /locus_tag="Rv0537c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane protein"
                     /protein_id="NP_215051.1"
                     /db_xref="GeneID:887465"
                     /translation="MGLSSDDTRRREVVRDLAAGALLIGALFFPWNLYFGFRIPDSSK
                     TVFGLLLAVTSLSLASLAVTFAGRRSQLRLGLNVPYLLLVLAFVVFDAIQTIRLGGTV
                     HVPGGVGPGGWLGITGALLSAQPALTGATTDEGSHSRWLRATQFLGYASMLGAALSTG
                     FNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYGVVALAAVLVASRWLLRPTAAEAL
                     STVALGGSTLIAGSIVWSLPIGREIDAFHGIAQNTSTAGVGYEGYLVWAAAAAMCAPL
                     TLFRSPNAPPIDKTVWRAASRNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSM
                     ALAAFDLATAVLAIWLRFNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRFQAS
                     SGGSAHPVYGNDLAQQITSTFDVVLCGLALSILAAAIVIGRLRQLPQPPHTPALSRPA
                     GSPRIFRSAGSTHPVRPKIYRPPDHSS"
     gene            630040..631686
                     /locus_tag="Rv0538"
                     /db_xref="GeneID:887473"
     CDS             630040..631686
                     /locus_tag="Rv0538"
                     /experiment="COORDINATES:Mass spectrometry[PMID:21969609]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein"
                     /protein_id="NP_215052.1"
                     /db_xref="GeneID:887473"
                     /translation="MDVALGVAVTDRVARLALVDSAAPGTVIDQFVLDVAEHPVEVLT
                     ETVVGTDRSLAGENHRLVATRLCWPDQAKADELQHALQDSGVHDVAVISEAQAATALV
                     GAAHAGSAVLLVGDETATLSVVGDPDAPPTMVAVAPVAGADATSTVDTLMARLGDQAL
                     APGDVFLVGRSAEHTTVLADQLRAASTMRVQTPDDPTFALARGAAMAAGAATMAHPAL
                     VADATTSLPRAEAGQSGSEGEQLAYSQASDYELLPVDEYEEHDEYGAAADRSAPLSRR
                     SLLIGNAVVAFAVIGFASLAVAVAVTIRPTAASKPVEGHQNAQPGKFMPLLPTQQQAP
                     VPPPPPDDPTAGFQGGTIPAVQNVVPRPGTSPGVGGTPASPAPEAPAVPGVVPAPVPI
                     PVPIIIPPFPGWQPGMPTIPTAPPTTPVTTSATTPPTTPPTTPVTTPPTTPPTTPVTT
                     PPTTPPTTPVTTPPTTVAPTTVAPTTVAPTTVAPTTVAPATATPTTVAPQPTQQPTQQ
                     PTQQMPTQQQTVAPQTVAPAPQPPSGGRNGSGGGDLFGGF"
     gene            631743..632375
                     /locus_tag="Rv0539"
                     /db_xref="GeneID:887476"
     CDS             631743..632375
                     /locus_tag="Rv0539"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /inference="protein motif:PROSITE:PS00017"
                     /note="dolichol-phosphate sugar synthetase
                     (dolichol-phosphate sugar transferase) (sugar
                     phosphoryldolichol synthase)"
                     /codon_start=1
                     /transl_table=11
                     /product="dolichyl-phosphate sugar synthase"
                     /protein_id="NP_215053.1"
                     /db_xref="GeneID:887476"
                     /translation="MLPCLNEEESLPAVLAAIPAGYRALVVDNNSTDDTATVAARHGA
                     QVVVEPRPGYGSAVHAGVLAATTPIVAVIDADGSMDAGDLPKLVAELDKGADLVTGRR
                     RPVAGLHWPWVARVGTVVMSWRLRTRHRLPVHDIAPMRVARREALLDLGVVDRRSGYP
                     LELLVRAAAAGWRVVELDVSYGPRTGGKSKVSGSLRGSIIAILDFWKVIS"
     misc_feature    631746..632243
                     /locus_tag="Rv0539"
                     /note="DPM_DPG-synthase_like is a member of the
                     Glycosyltransferase 2 superfamily; Region:
                     DPM_DPG-synthase_like; cd04179"
                     /db_xref="CDD:133022"
     misc_feature    order(631749..631751,631755..631757,631968..631970)
                     /locus_tag="Rv0539"
                     /note="Ligand binding site; other site"
                     /db_xref="CDD:133022"
     misc_feature    order(631827..631829,631965..631970)
                     /locus_tag="Rv0539"
                     /note="Putative Catalytic site; other site"
                     /db_xref="CDD:133022"
     misc_feature    631962..631970
                     /locus_tag="Rv0539"
                     /note="DXD motif; other site"
                     /db_xref="CDD:133022"
     gene            632372..633034
                     /locus_tag="Rv0540"
                     /db_xref="GeneID:887489"
     CDS             632372..633034
                     /locus_tag="Rv0540"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:14532352]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215054.1"
                     /db_xref="GeneID:887489"
                     /translation="MSCLPVSVLVVAKAPEPGRVKTRLAAAIGDKVAADIAAAALLDT
                     LDAVAAAPVTARAVALTGDLDSAADSAEIRRRLKSFTVFRQRGDAFADRLANAHVDAA
                     DGYPVLQIGMDTPQVTAELLADCARLLLQIPAVLGLAFDGGWWVLGIRTPTAAECLRA
                     VPMSQPDTGELTLKALRDNGIDVTLVQRLGDFDIVDDIALVRDCCAPGSRFAQATRAA
                     GL"
     misc_feature    632375..633007
                     /locus_tag="Rv0540"
                     /note="Uncharacterized conserved protein,
                     glycosyltransferase A (GT-A) superfamily, DUF2064 family
                     [Function unknown]; Region: COG3222"
                     /db_xref="CDD:225763"
     gene            complement(633055..634404)
                     /locus_tag="Rv0541c"
                     /db_xref="GeneID:887416"
     CDS             complement(633055..634404)
                     /locus_tag="Rv0541c"
                     /inference="protein motif:PROSITE:PS00041"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane protein"
                     /protein_id="NP_215055.1"
                     /db_xref="GeneID:887416"
                     /translation="MRIGRREGLAVAIGFVLVGAAFVLPRLNLGIKPRSDIGLERFAT
                     RAGAAPIFGYWDAHVGWGTAPAVLTAVAVVAWGPVVAHRLPWRVLTLSTWATAAAWAF
                     SLAMIDGWQRGFAGRLTTRDEYLWQVPGIADIPATLRTFTSRILDFQPNSWVTHVSGH
                     PPGALLTFVWLDRIGLRGGGWAGLVCLLVGSSAAAAVLIAVRVLASEQMARRTAPFVA
                     VAPTAIWIAVSADGYFAGVAAWGIALLAVAVHGATRFPALVAAGAGLLLGWGVFLNYG
                     LVLIVLPGMAVLAAADWRPVLRALGPAVLAALVVAVSFAVAGFSWFDGYTLVQQRYWQ
                     GIAKDRPFGYWSWANLACVVCAIGLGSVAGLSRVFDRAAISRRSGCHLLLLAVLAAIA
                     LADLSMLSKAETERIWLPFTIWLTAAPALLPPRSHRLWLAVNAAGALLLNSIIFTNW"
     gene            complement(634416..635504)
                     /gene="menE"
                     /locus_tag="Rv0542c"
                     /db_xref="GeneID:887507"
     CDS             complement(634416..635504)
                     /gene="menE"
                     /locus_tag="Rv0542c"
                     /inference="protein motif:PROSITE:PS00455"
                     /note="OSB-CoA synthetase (O-succinylbenzoate-CoA
                     synthase)"
                     /codon_start=1
                     /transl_table=11
                     /product="2-succinylbenzoic acid--CoA ligase"
                     /protein_id="NP_215056.1"
                     /db_xref="GeneID:887507"
                     /translation="MLGGSDPALVAVPTQHESLLGALRVGEQIDDDVALVVTTSGTTG
                     PPKGAMLTAAALTASASAAHDRLGGPGSWLLAVPPYHIAGLAVLVRSVIAGSVPVELN
                     VSAGFDVTELPNAIKRLGSGRRYTSLVAAQLAKALTDPAATAALAELDAVLIGGGPAP
                     RPILDAAAAAGITVVRTYGMSETSGGCVYDGVPLDGVRLRVLAGGRIAIGGATLAKGY
                     RNPVSPDPFAEPGWFHTDDLGALESGDSGVLTVLGRADEAISTGGFTVLPQPVEAALG
                     THPAVRDCAVFGLADDRLGQRVVAAIVVGDGCPPPTLEALRAHVARTLDVTAAPRELH
                     VVNVLPRRGIGKVDRAALVRRFAGEADQ"
     misc_feature    complement(634428..635504)
                     /gene="menE"
                     /locus_tag="Rv0542c"
                     /note="O-succinylbenzoic acid--CoA ligase; Provisional;
                     Region: PRK07824"
                     /db_xref="CDD:236108"
     gene            complement(635573..635875)
                     /locus_tag="Rv0543c"
                     /db_xref="GeneID:887494"
     CDS             complement(635573..635875)
                     /locus_tag="Rv0543c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_215057.1"
                     /db_xref="GeneID:887494"
                     /translation="MNRFLTSIVAWLRAGYPEGIPPTDSFAVLALLCRRLSHDEVKAV
                     ANELMRLGDFDQIDIGVVITHFTDELPSPEDVERVRARLAAQGWPLDDVRDREEHA"
     misc_feature    complement(635600..635866)
                     /locus_tag="Rv0543c"
                     /note="Protein of unknown function (DUF3349); Region:
                     DUF3349; pfam11829"
                     /db_xref="CDD:314661"
     gene            complement(635935..636213)
                     /locus_tag="Rv0544c"
                     /db_xref="GeneID:887511"
     CDS             complement(635935..636213)
                     /locus_tag="Rv0544c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:20429878]"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21920479]"
                     /note="A core mycobacterial gene; conserved in
                     mycobacterial strains (See Marmiesse et al., 2004
                     PMID:14766927)."
                     /codon_start=1
                     /transl_table=11
                     /product="transmembrane protein"
                     /protein_id="NP_215058.1"
                     /db_xref="GeneID:887511"
                     /translation="MSAWFNYTATLKILIFSLLAGALLPGLFAVGVRLQAAGDGADAT
                     ARRRPLLVAVSWAIFALVLAVVIIGVLYIARDFIAHHTGWAFLGATPK"
     gene            complement(636210..637463)
                     /gene="pitA"
                     /locus_tag="Rv0545c"
                     /db_xref="GeneID:887517"
     CDS             complement(636210..637463)
                     /gene="pitA"
                     /locus_tag="Rv0545c"
                     /experiment="EXISTENCE:Mass spectrometry[PMID:21085642]"
                     /note="integral membrane protein PitA"
                     /codon_start=1
                     /transl_table=11
                     /product="low-affinity inorganic phosphate transporter"
                     /protein_id="NP_215059.1"
                     /db_xref="GeneID:887517"
                     /translation="MNLQLFLLLIVVVTALAFDFTNGFHDTGNAMATSIASGALAPRV
                     AVALPAVLNLIGAFLSTAVAATIAKGLIDANLVTLELVFAGLVGGIVWNLLTWLLGIP
                     SSSSHALIGGIVGATIAAVGLRGVIWSGVVSKVIVPAVVAALLATLVGAVGTWLVYRT
                     TRGVAEKRTERGFRRGQIGSASLVSLAHGTNDAQKTMGVIFLALMSYGAVSTTASVPP
                     LWVIVSCAVAMAAGTYLGGWRIIRTLGKGLVEIKPPQGMAAESSSAAVILLSAHFGYA
                     LSTTQVATGSVLGSGVGKPGAEVRWGVAGRMVVAWLVTLPLAGLVGAFTYGLVHFIGG
                     YPGAILGFALLWLTATAIWLRSRRAPIDHTNVNADWEGNLTAGLEAGAQPLADQRPPV
                     PAPPAPTPPPNHRAPQFGVTTRNAP"
     misc_feature    complement(636465..637454)