LOCUS NC_008769 4374522 bp DNA circular BCT 29-DEC-2012
DEFINITION Mycobacterium bovis BCG str. Pasteur 1173P2 chromosome, complete
genome.
ACCESSION NC_008769
VERSION NC_008769.1 GI:121635883
DBLINK Project: 58781
BioProject: PRJNA58781
KEYWORDS complete genome.
SOURCE Mycobacterium bovis BCG str. Pasteur 1173P2
ORGANISM Mycobacterium bovis BCG str. Pasteur 1173P2
Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
tuberculosis complex.
REFERENCE 1 (bases 1 to 4374522)
AUTHORS Brosch,R., Gordon,S.V., Garnier,T., Eiglmeier,K., Frigui,W.,
Valenti,P., Dos Santos,S., Duthoy,S., Lacroix,C., Garcia-Pelayo,C.,
Inwald,J.K., Golby,P., Garcia,J.N., Hewinson,R.G., Behr,M.A.,
Quail,M.A., Churcher,C., Barrell,B.G., Parkhill,J. and Cole,S.T.
TITLE Genome plasticity of BCG and impact on vaccine efficacy
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 104 (13), 5596-5601 (2007)
PUBMED 17372194
REFERENCE 2 (bases 1 to 4374522)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (10-JAN-2007) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 4374522)
AUTHORS Garnier,T.
TITLE Direct Submission
JOURNAL Submitted (23-OCT-2006) Garnier T., Unite Genetique Moleculaire
Bacterienne, Institut Pasteur, 28,rue du Dr ROUX, PARIS, 75015,
FRANCE. Garnier T., submitted on behalf of the Mycobacterium bovis
sequencing teams, TB Research Group, Veterinary Laboratories Agency
Weybridge, Woodham Lane, New Haw,Addlestone, Surrey KT15 3NB, UK.
Sanger Centre, Wellcome Trust Genome Campus, Hinxton,Cambridge CB10
1SA, UK. PT4 Annotation, Genopole, Institut Pasteur, 28 Rue du
Docteur Roux, 75724 Paris Cedex 15, France. Unite de Genetique
Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux,
75724 Paris Cedex 15, France
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AM408590.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..4374522
/organism="Mycobacterium bovis BCG str. Pasteur 1173P2"
/mol_type="genomic DNA"
/strain="BCG Pasteur 1173P2"
/db_xref="taxon:410289"
gene 1..1524
/gene="dnaA"
/locus_tag="BCG_0001"
/db_xref="GeneID:4697358"
CDS 1..1524
/gene="dnaA"
/locus_tag="BCG_0001"
/note="binds to the dnaA-box as an ATP-bound complex at
the origin of replication during the initiation of
chromosomal replication; can also affect transcription of
multiple genes including itself."
/codon_start=1
/transl_table=11
/product="chromosomal replication initiation protein"
/protein_id="YP_976107.1"
/db_xref="GI:121635884"
/db_xref="GeneID:4697358"
/translation="MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQ
RAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAP
PATDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPRNTDS
ATAGVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLL
HAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFI
EGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPE
LETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDK
ALAEIVLRDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYL
CRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR"
misc_feature 100..1509
/gene="dnaA"
/locus_tag="BCG_0001"
/note="chromosomal replication initiation protein;
Reviewed; Region: dnaA; PRK00149"
/db_xref="CDD:178902"
misc_feature 601..978
/gene="dnaA"
/locus_tag="BCG_0001"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature 622..645
/gene="dnaA"
/locus_tag="BCG_0001"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature order(625..648,811..813,910..912)
/gene="dnaA"
/locus_tag="BCG_0001"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature 799..816
/gene="dnaA"
/locus_tag="BCG_0001"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature 949..951
/gene="dnaA"
/locus_tag="BCG_0001"
/note="arginine finger; other site"
/db_xref="CDD:99707"
misc_feature 1243..1503
/gene="dnaA"
/locus_tag="BCG_0001"
/note="C-terminal domain of bacterial DnaA proteins. The
DNA-binding C-terminal domain of DnaA contains a
helix-turn-helix motif that specifically interacts with
the DnaA box, a 9-mer motif that occurs repetitively in
the replication origin oriC. Multiple...; Region:
Bac_DnaA_C; cd06571"
/db_xref="CDD:119330"
misc_feature order(1306..1308,1330..1335,1354..1356,1372..1380,
1402..1416,1423..1425,1432..1437)
/gene="dnaA"
/locus_tag="BCG_0001"
/note="DnaA box-binding interface [nucleotide binding];
other site"
/db_xref="CDD:119330"
gene 2052..3260
/gene="dnaN_1"
/locus_tag="BCG_0002"
/db_xref="GeneID:4697407"
CDS 2052..3260
/gene="dnaN_1"
/locus_tag="BCG_0002"
/EC_number="2.7.7.7"
/note="binds the polymerase to DNA and acts as a sliding
clamp"
/codon_start=1
/transl_table=11
/product="DNA polymerase III subunit beta"
/protein_id="YP_976108.1"
/db_xref="GI:121635885"
/db_xref="GeneID:4697407"
/translation="MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSG
VLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVGVHV
EGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDT
LPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAG
IGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMD
VAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIA
FNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYV
YLLMPVRLPG"
misc_feature 2094..3257
/gene="dnaN_1"
/locus_tag="BCG_0002"
/note="DNA polymerase III subunit beta; Validated; Region:
PRK07761"
/db_xref="CDD:181105"
misc_feature 2094..3248
/gene="dnaN_1"
/locus_tag="BCG_0002"
/note="Beta clamp domain. The beta subunit (processivity
factor) of DNA polymerase III holoenzyme, refered to as
the beta clamp, forms a ring shaped dimer that encircles
dsDNA (sliding clamp) in bacteria. The beta-clamp is
structurally similar to the trimeric...; Region:
beta_clamp; cd00140"
/db_xref="CDD:29053"
misc_feature order(2157..2159,2301..2303,2322..2324,2676..2678)
/gene="dnaN_1"
/locus_tag="BCG_0002"
/note="putative DNA binding surface [nucleotide binding];
other site"
/db_xref="CDD:29053"
misc_feature order(2304..2306,2313..2315,2388..2390,2394..2396,
2916..2918,3006..3011)
/gene="dnaN_1"
/locus_tag="BCG_0002"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:29053"
misc_feature order(2592..2594,2598..2609,3057..3059,3237..3248)
/gene="dnaN_1"
/locus_tag="BCG_0002"
/note="beta-clamp/clamp loader binding surface; other
site"
/db_xref="CDD:29053"
misc_feature order(2592..2594,2598..2603,2841..2843,2943..2945,
2982..2987,3066..3068,3237..3248)
/gene="dnaN_1"
/locus_tag="BCG_0002"
/note="beta-clamp/translesion DNA polymerase binding
surface; other site"
/db_xref="CDD:29053"
gene 3280..4437
/gene="recF"
/locus_tag="BCG_0003"
/db_xref="GeneID:4695679"
CDS 3280..4437
/gene="recF"
/locus_tag="BCG_0003"
/note="Required for DNA replication; binds preferentially
to single-stranded, linear DNA"
/codon_start=1
/transl_table=11
/product="recombination protein F"
/protein_id="YP_976109.1"
/db_xref="GI:121635886"
/db_xref="GeneID:4695679"
/translation="MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALW
YSTTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSV
RSTRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVVRQ
RTALLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQL
LAPESRSASIGYRASMDVTGPSEQSDTDRQLLAARLLAALAARRDAELERGVCLVGPH
RDDLILRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVM
RRRALATAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP"
misc_feature 3280..4419
/gene="recF"
/locus_tag="BCG_0003"
/note="recF protein; Region: recf; TIGR00611"
/db_xref="CDD:233051"
misc_feature 3286..>3777
/gene="recF"
/locus_tag="BCG_0003"
/note="ATP-binding cassette domain of RecF; Region:
ABC_RecF; cd03242"
/db_xref="CDD:213209"
misc_feature 3367..3390
/gene="recF"
/locus_tag="BCG_0003"
/note="Walker A/P-loop; other site"
/db_xref="CDD:213209"
misc_feature order(3376..3381,3385..3393,3583..3585)
/gene="recF"
/locus_tag="BCG_0003"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:213209"
misc_feature 3574..3585
/gene="recF"
/locus_tag="BCG_0003"
/note="Q-loop/lid; other site"
/db_xref="CDD:213209"
misc_feature <4093..4422
/gene="recF"
/locus_tag="BCG_0003"
/note="ATP-binding cassette transporter nucleotide-binding
domain; Region: ABC_ATPase; cl17201"
/db_xref="CDD:247755"
misc_feature 4156..4185
/gene="recF"
/locus_tag="BCG_0003"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:213179"
misc_feature 4240..4257
/gene="recF"
/locus_tag="BCG_0003"
/note="Walker B; other site"
/db_xref="CDD:213179"
misc_feature 4264..4275
/gene="recF"
/locus_tag="BCG_0003"
/note="D-loop; other site"
/db_xref="CDD:213179"
misc_feature 4330..4350
/gene="recF"
/locus_tag="BCG_0003"
/note="H-loop/switch region; other site"
/db_xref="CDD:213179"
gene 4434..4997
/locus_tag="BCG_0004"
/db_xref="GeneID:4696082"
CDS 4434..4997
/locus_tag="BCG_0004"
/note="Differs from Mb0004 by 1aa, S16L"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976110.1"
/db_xref="GI:121635887"
/db_xref="GeneID:4696082"
/translation="MTGSVDRPDQNRGERSMKSPGLDLVRRTLDEARAAARARGQDAG
RGRVASVASGRVAGRRRSWSGPGPDIRDPQPLGKAARELAKKRGWSVRVAEGMVLGQW
SAVVGHQIAEHARPTALNDGVLSVIAESTAWATQLRIMQAQLLAKIAAAVGNDVVRSL
KITGPAAPSWRKGPRHIAGRGPRDTYG"
misc_feature 4437..4994
/locus_tag="BCG_0004"
/note="hypothetical protein; Provisional; Region:
PRK03195"
/db_xref="CDD:179552"
gene 5123..7267
/gene="gyrB"
/locus_tag="BCG_0005"
/db_xref="GeneID:4695574"
CDS 5123..7267
/gene="gyrB"
/locus_tag="BCG_0005"
/EC_number="5.99.1.3"
/note="negatively supercoils closed circular
double-stranded DNA"
/codon_start=1
/transl_table=11
/product="DNA gyrase subunit B"
/protein_id="YP_976111.1"
/db_xref="GI:121635888"
/db_xref="GeneID:4695574"
/translation="MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQK
KKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYAT
TVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLH
GVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAV
FETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERA
AESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNA
GYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREG
LAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDSKVVVNKAV
SSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKS
GRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKI
VLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDR
ERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAA
ADELFSILMGEDVDARRSFITRNAKDVRFLDV"
misc_feature 5252..7264
/gene="gyrB"
/locus_tag="BCG_0005"
/note="DNA gyrase subunit B; Validated; Region: gyrB;
PRK05644"
/db_xref="CDD:180181"
misc_feature 5363..>5509
/gene="gyrB"
/locus_tag="BCG_0005"
/note="Histidine kinase-like ATPases; This family includes
several ATP-binding proteins for example: histidine
kinase, DNA gyrase B, topoisomerases, heat shock protein
HSP90, phytochrome-like ATPases and DNA mismatch repair
proteins; Region: HATPase_c; cd00075"
/db_xref="CDD:28956"
misc_feature 5393..5395
/gene="gyrB"
/locus_tag="BCG_0005"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28956"
misc_feature order(5480..5482,5486..5488)
/gene="gyrB"
/locus_tag="BCG_0005"
/note="G-X-G motif; other site"
/db_xref="CDD:28956"
misc_feature 6002..6517
/gene="gyrB"
/locus_tag="BCG_0005"
/note="TopoIIA_Trans_DNA_gyrase: Transducer domain, having
a ribosomal S5 domain 2-like fold, of the type found in
proteins of the type IIA family of DNA topoisomerases
similar to the B subunits of E. coli DNA gyrase and E.
coli Topoisomerase IV which are; Region:
TopoII_Trans_DNA_gyrase; cd00822"
/db_xref="CDD:48467"
misc_feature 6155..6157
/gene="gyrB"
/locus_tag="BCG_0005"
/note="anchoring element; other site"
/db_xref="CDD:48467"
misc_feature order(6329..6331,6338..6343,6347..6349,6482..6487,
6497..6499,6509..6511)
/gene="gyrB"
/locus_tag="BCG_0005"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:48467"
misc_feature order(6347..6349,6353..6355)
/gene="gyrB"
/locus_tag="BCG_0005"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:48467"
misc_feature 6596..6937
/gene="gyrB"
/locus_tag="BCG_0005"
/note="TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM)
nucleotidyl transferase/hydrolase domain of the type found
in proteins of the type IIA family of DNA topoisomerases
similar to the Escherichia coli GyrB subunit. TopoIIA
enzymes cut both strands of the...; Region:
TOPRIM_TopoIIA_GyrB; cd03366"
/db_xref="CDD:173786"
misc_feature order(6614..6619,6626..6628,6833..6835,6839..6841,
6845..6847)
/gene="gyrB"
/locus_tag="BCG_0005"
/note="active site"
/db_xref="CDD:173786"
misc_feature order(6614..6616,6833..6835)
/gene="gyrB"
/locus_tag="BCG_0005"
/note="putative metal-binding site [ion binding]; other
site"
/db_xref="CDD:173786"
misc_feature 7025..7228
/gene="gyrB"
/locus_tag="BCG_0005"
/note="DNA gyrase B subunit, carboxyl terminus; Region:
DNA_gyraseB_C; pfam00986"
/db_xref="CDD:201537"
gene 7302..9818
/gene="gyrA_1"
/locus_tag="BCG_0006"
/db_xref="GeneID:4695442"
CDS 7302..9818
/gene="gyrA_1"
/locus_tag="BCG_0006"
/EC_number="5.99.1.3"
/note="negatively supercoils closed circular
double-stranded DNA"
/codon_start=1
/transl_table=11
/product="DNA gyrase subunit A"
/protein_id="YP_976112.1"
/db_xref="GI:121635889"
/db_xref="GeneID:4695442"
/translation="MTDTTLPPDDSLDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEV
RDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQP
WSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRV
QEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAA
VMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPY
QVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKH
TQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILR
GLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQR
IIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDE
DLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDL
ILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLV
LATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSADDDLLLVSANGQSIR
FSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEY
PVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQT
KGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN"
misc_feature 7341..9764
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA gyrase subunit A; Validated; Region: PRK05560"
/db_xref="CDD:235502"
misc_feature 7410..8759
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA Topoisomerase, subtype IIA; domain A';
bacterial DNA topoisomerase IV (C subunit, ParC),
bacterial DNA gyrases (A subunit, GyrA),mammalian DNA
toposiomerases II. DNA topoisomerases are essential
enzymes that regulate the conformational changes...;
Region: TOP4c; cd00187"
/db_xref="CDD:238111"
misc_feature order(7410..7493,7506..7655,7659..7715,7719..7790,
7797..7799)
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="CAP-like domain; other site"
/db_xref="CDD:238111"
misc_feature 7686..7688
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="active site"
/db_xref="CDD:238111"
misc_feature order(8496..8504,8511..8522,8553..8558,8598..8648)
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="primary dimer interface [polypeptide binding];
other site"
/db_xref="CDD:238111"
misc_feature 8844..8987
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 8994..9146
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 9165..9299
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 9306..9455
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 9465..9608
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 9618..9752
/gene="gyrA_1"
/locus_tag="BCG_0006"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
gene 9914..10828
/locus_tag="BCG_0007"
/db_xref="GeneID:4695440"
CDS 9914..10828
/locus_tag="BCG_0007"
/note="Differs from Rv0007 by 1aa, I272V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976113.1"
/db_xref="GI:121635890"
/db_xref="GeneID:4695440"
/translation="MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPP
PWQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADARLNRFISGASAPVTGPAAAVRT
PQPDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAG
SSGGRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMI
TVAFLYLVLGGMGVWAKLNSNVGDLLNNASGSSAELVSSGTIFGGAFLIGLVNIVLMT
ALATIGAFVYNLITDLIGGIEVTLADRD"
misc_feature 10466..10822
/locus_tag="BCG_0007"
/note="Transmembrane domain of unknown function (DUF3566);
Region: DUF3566; pfam12089"
/db_xref="CDD:152524"
gene 10887..10960
/gene="tRNA-Ile"
/locus_tag="BCG_ileT_1"
/db_xref="GeneID:4696536"
tRNA 10887..10960
/gene="tRNA-Ile"
/locus_tag="BCG_ileT_1"
/product="tRNA-Ile"
/note="ileT_1, len: 74 nt. First of two copies equivalent
to ileT, len: 74 nt, from Mycobacterium tuberculosis
strain H37Rv, (100.0% identity in 74 nt overlap).
tRNA-Ile, anticodon gat"
/anticodon=(pos:10921..10923,aa:Ile,seq:gat)
/codon_recognized="AUC"
/db_xref="GeneID:4696536"
gene 11112..11184
/gene="tRNA-Ala"
/locus_tag="BCG_alaT_1"
/db_xref="GeneID:4696332"
tRNA 11112..11184
/gene="tRNA-Ala"
/locus_tag="BCG_alaT_1"
/product="tRNA-Ala"
/note="alaT_1, len: 73 nt. First of two copies equivalent
to alaT, len: 73 nt, from Mycobacterium tuberculosis
strain H37Rv, (100.0% identity in 73 nt overlap).
tRNA-Ala, anticodon tgc"
/anticodon=(pos:11145..11147,aa:Ala,seq:tgc)
/codon_recognized="GCA"
/db_xref="GeneID:4696332"
gene complement(11874..12311)
/locus_tag="BCG_0008c"
/db_xref="GeneID:4697331"
CDS complement(11874..12311)
/locus_tag="BCG_0008c"
/note="Differs from Rv0008c by 1aa, P145S"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976114.1"
/db_xref="GI:121635891"
/db_xref="GeneID:4697331"
/translation="MSEQVETRLTPRERLTRGLAYSAVGPVDVTRGLLELGVGLGLQS
ARSTAAGLRRRYREGRLAREVAAAQETLAQELTAAQDVVANLPQALQDARTQRRSKHH
LWIFAGIAAAILAGGAVAFSIVRRSSRPEPSPRPPSVEVQPRP"
misc_feature complement(<12000..12260)
/locus_tag="BCG_0008c"
/note="Protein of unknown function (DUF2562); Region:
DUF2562; pfam10814"
/db_xref="CDD:151264"
gene 12468..13016
/gene="ppiA_1"
/locus_tag="BCG_0009"
/db_xref="GeneID:4697477"
CDS 12468..13016
/gene="ppiA_1"
/locus_tag="BCG_0009"
/EC_number="5.2.1.8"
/standard_name="cfp22"
/codon_start=1
/transl_table=11
/product="iron-regulated peptidyl-prolyl cis-trans
isomerase A ppiA"
/protein_id="YP_976115.1"
/db_xref="GI:121635892"
/db_xref="GeneID:4697477"
/translation="MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVG
LAQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFH
PELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAIS
KTATDGNDRPTDPVVIESITIS"
misc_feature 12519..13001
/gene="ppiA_1"
/locus_tag="BCG_0009"
/note="cyclophilin: cyclophilin-type peptidylprolyl cis-
trans isomerases. This family contains eukaryotic,
bacterial and archeal proteins which exhibit a
peptidylprolyl cis- trans isomerases activity (PPIase,
Rotamase) and in addition bind the...; Region:
cyclophilin; cd00317"
/db_xref="CDD:238194"
misc_feature order(12684..12686,12690..12692,12699..12704,12708..12710,
12813..12818,12843..12845,12849..12851,12873..12878,
12888..12890)
/gene="ppiA_1"
/locus_tag="BCG_0009"
/note="active site"
/db_xref="CDD:238194"
gene complement(13222..13557)
/locus_tag="BCG_0010c"
/db_xref="GeneID:4698099"
CDS complement(13222..13557)
/locus_tag="BCG_0010c"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a single base deletion (g-*) leads to
a shorter product compared to its homolog in Mycobacterium
tuberculosis strain H37Rv (111 aa versus 141 aa)"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976116.1"
/db_xref="GI:121635893"
/db_xref="GeneID:4698099"
/translation="MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAA
LGLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLL
EIETVSGGC"
misc_feature complement(<13264..13386)
/locus_tag="BCG_0010c"
/note="Protein of unknown function (DUF2581); Region:
DUF2581; pfam10756"
/db_xref="CDD:204551"
gene complement(13713..13994)
/locus_tag="BCG_0011c"
/db_xref="GeneID:4695508"
CDS complement(13713..13994)
/locus_tag="BCG_0011c"
/note="integral membrane protein involved in inhibition of
the Z-ring formation"
/codon_start=1
/transl_table=11
/product="septation inhibitor protein"
/protein_id="YP_976117.1"
/db_xref="GI:121635894"
/db_xref="GeneID:4695508"
/translation="MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIG
LIWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH"
misc_feature complement(13716..13994)
/locus_tag="BCG_0011c"
/note="putative septation inhibitor protein; Reviewed;
Region: PRK00159"
/db_xref="CDD:178907"
gene 14088..14876
/locus_tag="BCG_0012"
/db_xref="GeneID:4699131"
CDS 14088..14876
/locus_tag="BCG_0012"
/note="Differs from Rv0012 by 2aa, E105K, R233C"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976118.1"
/db_xref="GI:121635895"
/db_xref="GeneID:4699131"
/translation="MRLTHPTPCPENGETMIDRRRSAWRFSVPLVCLLAGLLLAATHG
VSGGTEIRRSDAPRLVDLVRRAQASVNRLATEREALTTRIDSVHGRSVDTALAAMQRR
SAELAGVAAMNPVHGPGLVVTLQDAQRDANGRFPRDASPDDLVVHQQDIEAVLNALWN
AGAEAIQMQDQRIIAMSIARCVGNTLLLNGRTYSPPYTIAAIGDAAAMQAALAAAPLV
TLYKQYVVRFGLGYREEVHPDLQIVGYADPVRMHFAQPAGPLDY"
misc_feature 14097..14864
/locus_tag="BCG_0012"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG3879"
/db_xref="CDD:33668"
misc_feature 14385..14858
/locus_tag="BCG_0012"
/note="Bacterial protein of unknown function (DUF881);
Region: DUF881; pfam05949"
/db_xref="CDD:191409"
gene 14913..15611
/gene="trpG_1"
/locus_tag="BCG_0013"
/db_xref="GeneID:4698875"
CDS 14913..15611
/gene="trpG_1"
/locus_tag="BCG_0013"
/note="aminodeoxychorismate synthase subunit PabA; with
PabB catalyzes the formation of 4-amino-4-deoxychorismate
from chorismate and glutamine in para-aminobenzoate
synthesis; PabA provides the glutamine amidotransferase
activity"
/codon_start=1
/transl_table=11
/product="para-aminobenzoate synthase component II"
/protein_id="YP_976119.1"
/db_xref="GI:121635896"
/db_xref="GeneID:4698875"
/translation="MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVA
GQFDGVLLSPGPGTPERAGASVSMVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPE
LLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQ
HTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPT
STASAGEATGRTSA"
misc_feature 14919..15479
/gene="trpG_1"
/locus_tag="BCG_0013"
/note="Type 1 glutamine amidotransferase (GATase1) domain
found in Anthranilate synthase; Region:
GATase1_Anthranilate_Synthase; cd01743"
/db_xref="CDD:153214"
misc_feature 14922..15479
/gene="trpG_1"
/locus_tag="BCG_0013"
/note="Glutamine amidotransferase class-I; Region: GATase;
pfam00117"
/db_xref="CDD:215729"
misc_feature order(15072..15077,15081..15083,15159..15164,15171..15173,
15303..15314)
/gene="trpG_1"
/locus_tag="BCG_0013"
/note="glutamine binding [chemical binding]; other site"
/db_xref="CDD:153214"
misc_feature order(15159..15161,15426..15428,15432..15434)
/gene="trpG_1"
/locus_tag="BCG_0013"
/note="catalytic triad [active]"
/db_xref="CDD:153214"
gene complement(15589..16734)
/gene="pknB"
/locus_tag="BCG_0014c"
/pseudo
/db_xref="GeneID:4695828"
gene 16731..18287
/locus_tag="BCG_0015"
/pseudo
/db_xref="GeneID:4698696"
repeat_region 16733..46399
/note="DU1, len: 29667 bases. Duplicated Region DU1. In
Mycobacterium bovis BCG Pasteur, the region corresponding
to Mycobacterium tuberculosis H37Rv
positions:4398597-16733 (comprising the origin of
replication) has been duplicated as tandem repeat at
position: 4361588..16732 and 16733..46399. No difference
has been found beetwen the two copies"
gene 18322..18912
/gene="sigMa_2"
/locus_tag="BCG_0016"
/db_xref="GeneID:4696441"
CDS 18322..18912
/gene="sigMa_2"
/locus_tag="BCG_0016"
/note="Member of the extracytoplasmic function sigma
factors which are active under specific conditions; binds
with the catalytic core of RNA polymerase to produce the
holoenzyme and directs bacterial core RNA polymerase to
specific promoter elements to initiate transcription: in
Mycobacterium bovis this protein has been shown to be
active at high temperatures and during stationary phase"
/codon_start=1
/transl_table=11
/product="RNA polymerase sigma factor SigM"
/protein_id="YP_976120.1"
/db_xref="GI:121635897"
/db_xref="GeneID:4696441"
/translation="MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHH
RQLHRLARLTSRTSEDADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACLDRLR
RAKAHPTAPLEDVYPVADRTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTA
RMLGVAEGTVKSRCARARARLARLLGYLNTGVNIRR"
misc_feature 18334..18906
/gene="sigMa_2"
/locus_tag="BCG_0016"
/note="RNA polymerase sigma factor SigM; Reviewed; Region:
PRK09643"
/db_xref="CDD:236604"
misc_feature <18487..18639
/gene="sigMa_2"
/locus_tag="BCG_0016"
/note="Sigma-70 region 2; Region: Sigma70_r2; pfam04542"
/db_xref="CDD:218138"
misc_feature 18706..18840
/gene="sigMa_2"
/locus_tag="BCG_0016"
/note="Sigma70, region (SR) 4 refers to the most
C-terminal of four conserved domains found in Escherichia
coli (Ec) sigma70, the main housekeeping sigma, and
related sigma-factors (SFs). A SF is a dissociable subunit
of RNA polymerase, it directs bacterial or...; Region:
Sigma70_r4; cd06171"
/db_xref="CDD:100119"
misc_feature order(18736..18738,18766..18768,18784..18789,18817..18819,
18823..18828,18832..18840)
/gene="sigMa_2"
/locus_tag="BCG_0016"
/note="DNA binding residues [nucleotide binding]"
/db_xref="CDD:100119"
gene 18801..18989
/gene="sigMb_2"
/locus_tag="BCG_0017"
/pseudo
/db_xref="GeneID:4696446"
gene 19005..19769
/locus_tag="BCG_0018"
/db_xref="GeneID:4697289"
CDS 19005..19769
/locus_tag="BCG_0018"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976121.1"
/db_xref="GI:121635898"
/db_xref="GeneID:4697289"
/translation="MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRV
RSDPQAQQILRALNRVRRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAH
AARPHVHPVRMIAGAAGLCAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPL
SRPQVLDLLHHTPDYGPPGGPLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVL
LVIPADTPDKLAVFAVAPHCSAADTGLLASTVVPRA"
gene 19863..20870
/gene="trxB2_2"
/locus_tag="BCG_0019"
/db_xref="GeneID:4695650"
CDS 19863..20870
/gene="trxB2_2"
/locus_tag="BCG_0019"
/EC_number="1.8.1.9"
/note="Differs from Rv3913 by 1aa, G57D"
/codon_start=1
/transl_table=11
/product="thioredoxin reductase trxB2 (TRXR)"
/protein_id="YP_976122.1"
/db_xref="GI:121635899"
/db_xref="GeneID:4695650"
/translation="MTAPPVHDRAHHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFE
GTSFGGALMTTTGVENYPGFRNGITGPELMDEMREQALRFGADLRMEDVESVSLHGPL
KSVVTADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAV
IGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVD
GDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQGRTT
STSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAATGEADSTDALIGAQ
R"
misc_feature 19908..20807
/gene="trxB2_2"
/locus_tag="BCG_0019"
/note="thioredoxin-disulfide reductase; Region:
TRX_reduct; TIGR01292"
/db_xref="CDD:233345"
misc_feature <20091..20426
/gene="trxB2_2"
/locus_tag="BCG_0019"
/note="NAD(P)-binding Rossmann-like domain; Region:
NAD_binding_8; cl17500"
/db_xref="CDD:248054"
misc_feature 20334..>20498
/gene="trxB2_2"
/locus_tag="BCG_0019"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox; pfam00070"
/db_xref="CDD:215691"
gene 20867..21217
/gene="trxC_2"
/locus_tag="BCG_0020"
/db_xref="GeneID:4696834"
CDS 20867..21217
/gene="trxC_2"
/locus_tag="BCG_0020"
/EC_number="1.-.-.-"
/standard_name="trx; trxA"
/codon_start=1
/transl_table=11
/product="thioredoxin trxC (TRX) (MPT46)"
/protein_id="YP_976123.1"
/db_xref="GI:121635900"
/db_xref="GeneID:4696834"
/translation="MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVA
PVLEEIATERATDLTVAKLDVDTNPETARNFQVVSIPTLILFKDGQPVKRIVGAKGKA
ALLRELSDVVPNLN"
misc_feature 20924..21190
/gene="trxC_2"
/locus_tag="BCG_0020"
/note="TRX family; composed of two groups: Group I, which
includes proteins that exclusively encode a TRX domain;
and Group II, which are composed of fusion proteins of TRX
and additional domains. Group I TRX is a small ancient
protein that alter the redox...; Region: TRX_family;
cd02947"
/db_xref="CDD:239245"
misc_feature 20939..21133
/gene="trxC_2"
/locus_tag="BCG_0020"
/note="Thioredoxin-like; Region: Thioredoxin_8; pfam13905"
/db_xref="CDD:222448"
misc_feature order(20975..20977,20984..20986)
/gene="trxC_2"
/locus_tag="BCG_0020"
/note="catalytic residues [active]"
/db_xref="CDD:239245"
gene 21327..22547
/locus_tag="BCG_0021"
/db_xref="GeneID:4697088"
CDS 21327..22547
/locus_tag="BCG_0021"
/EC_number="3.-.-.-"
/codon_start=1
/transl_table=11
/product="hydrolase"
/protein_id="YP_976124.1"
/db_xref="GI:121635901"
/db_xref="GeneID:4697088"
/translation="MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTG
RNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAP
LYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSL
YFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEA
DLLWDLASRLEGRMAAIGMETHLSRPTNRSPSDAERAATANAVGADLMISLRCETQTS
LAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRVHGRTWDLLRLTRMP
TVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLA
HELSVERAGRLGGS"
misc_feature 21327..21806
/locus_tag="BCG_0021"
/note="Putative peptidoglycan-binding domain-containing
protein [Cell envelope biogenesis, outer membrane];
Region: COG3409"
/db_xref="CDD:225943"
misc_feature 21375..21575
/locus_tag="BCG_0021"
/note="Putative peptidoglycan binding domain; Region:
PG_binding_1; pfam01471"
/db_xref="CDD:216518"
misc_feature 21639..21806
/locus_tag="BCG_0021"
/note="Putative peptidoglycan binding domain; Region:
PG_binding_1; pfam01471"
/db_xref="CDD:216518"
misc_feature 21792..22454
/locus_tag="BCG_0021"
/note="N-acetylmuramoyl-L-alanine amidase [Cell envelope
biogenesis, outer membrane]; Region: AmiC; COG0860"
/db_xref="CDD:223929"
misc_feature 21900..22436
/locus_tag="BCG_0021"
/note="N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA
(also known as peptidoglycan aminohydrolase, NAMLA
amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC
3.5.1.28) is an autolysin that hydrolyzes the amide bond
between N-acetylmuramoyl and L-amino...; Region:
MurNAc-LAA; cd02696"
/db_xref="CDD:119407"
misc_feature order(21921..21923,21975..21977,22134..22136,22341..22343)
/locus_tag="BCG_0021"
/note="active site"
/db_xref="CDD:119407"
misc_feature order(21921..21923,21975..21977,22134..22136)
/locus_tag="BCG_0021"
/note="metal binding site [ion binding]; metal-binding
site"
/db_xref="CDD:119407"
gene complement(22568..23302)
/locus_tag="BCG_0022c"
/db_xref="GeneID:4695702"
CDS complement(22568..23302)
/locus_tag="BCG_0022c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976125.1"
/db_xref="GI:121635902"
/db_xref="GeneID:4695702"
/translation="MSARITALRLEAFEQLPKHARRCVFWEVDPAILGKDDHLADPEF
EKEAWLSMVMLEWGSCGQVATAVPDERSHAEPPCLGYVLYAPPSAVPRAQRFPTAPVS
ADAVLLTSMGIERGQADDDLPHSLIARVIEELVRRGVRALEAFGRTPAATDLQNPGAV
TPDVRPVLEALGDCCVEHCIIDANFLMDVGFVVVAPHPYFPRLRLELDKGLGWKAEVE
AALERLLENARLQEPIAAGSTAGNTS"
gene complement(23592..24626)
/gene="parB_2"
/locus_tag="BCG_0023c"
/db_xref="GeneID:4695600"
CDS complement(23592..24626)
/gene="parB_2"
/locus_tag="BCG_0023c"
/codon_start=1
/transl_table=11
/product="chromosome partitioning protein parB"
/protein_id="YP_976126.1"
/db_xref="GI:121635903"
/db_xref="GeneID:4695600"
/translation="MTQPSRRKGGLGRGLAALIPTGPADGESGPPTLGPRMGSATADV
VIGGPVPDTSVMGAIYREIPPSAIEANPRQPRQVFDEEALAELVHSIREFGLLQPIVV
RSLAGSQTGVRYQIVMGERRWRAAQEAGLATIPAIVRETGDDNLLRDALLENIHRVQL
NPLEEAAAYQQLLDEFGVTHDELAARIGRSRPLITNMIRLLKLPIPVQRRVAAGVLSA
GHARALLSLEAGPEAQEELASRIVAEGLSVRATEETVTLANHEANRQAHHSDATTPAP
PRRKPIQMPGLQDVAERLSTTFDTRVTVSLGKRKGKIVVEFGSVDDLARIVGLMTTDG
RDKGLHRDAL"
misc_feature complement(23904..24461)
/gene="parB_2"
/locus_tag="BCG_0023c"
/note="ParB/RepB/Spo0J family partition protein; Region:
parB_part; TIGR00180"
/db_xref="CDD:232860"
misc_feature complement(24162..24446)
/gene="parB_2"
/locus_tag="BCG_0023c"
/note="ParB-like nuclease domain; Region: ParB;
smart00470"
/db_xref="CDD:214678"
gene complement(24623..25666)
/gene="parA_2"
/locus_tag="BCG_0024c"
/db_xref="GeneID:4697551"
CDS complement(24623..25666)
/gene="parA_2"
/locus_tag="BCG_0024c"
/codon_start=1
/transl_table=11
/product="chromosome partitioning protein parA"
/protein_id="YP_976127.1"
/db_xref="GI:121635904"
/db_xref="GeneID:4697551"
/translation="MSAPWGPVAAGPSALVRSGQASTIEPFQREMTPPTPTPEAAHNP
TMNVSRETSTEFDTPIGAAAERAMRVLHTTHEPLQRPGRRRVLTIANQKGGVGKTTTA
VNIAAALAVQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEMLIGEVSLHTALRRS
PHSERLFCIPATIDLAGAEIELVSMVARENRLRTALAALDNFDFDYVFVDCPPSLGLL
TINALVAAPEVMIPIQCEYYALEGVSQLMRNIEMVKAHLNPQLEVTTVILTMYDGRTK
LADQVADEVRQYFGSKVLRTVIPRSVKVSEAPGYSMTIIDYDPGSRGAMSYLDASREL
AERDRPPSAKGRP"
misc_feature complement(24656..25414)
/gene="parA_2"
/locus_tag="BCG_0024c"
/note="ATPases involved in chromosome partitioning [Cell
division and chromosome partitioning]; Region: Soj;
COG1192"
/db_xref="CDD:224113"
misc_feature complement(<25295..25411)
/gene="parA_2"
/locus_tag="BCG_0024c"
/note="ParA and ParB of Caulobacter crescentus belong to a
conserved family of bacterial proteins implicated in
chromosome segregation. ParB binds to DNA sequences
adjacent to the origin of replication and localizes to
opposite cell poles shortly following the...; Region:
ParA; cd02042"
/db_xref="CDD:238997"
misc_feature complement(25370..25390)
/gene="parA_2"
/locus_tag="BCG_0024c"
/note="P-loop; other site"
/db_xref="CDD:238997"
misc_feature complement(25370..25372)
/gene="parA_2"
/locus_tag="BCG_0024c"
/note="Magnesium ion binding site [ion binding]; other
site"
/db_xref="CDD:238997"
misc_feature complement(24860..>25057)
/gene="parA_2"
/locus_tag="BCG_0024c"
/note="ParA and ParB of Caulobacter crescentus belong to a
conserved family of bacterial proteins implicated in
chromosome segregation. ParB binds to DNA sequences
adjacent to the origin of replication and localizes to
opposite cell poles shortly following the...; Region:
ParA; cd02042"
/db_xref="CDD:238997"
misc_feature complement(25037..25039)
/gene="parA_2"
/locus_tag="BCG_0024c"
/note="Magnesium ion binding site [ion binding]; other
site"
/db_xref="CDD:238997"
gene complement(25663..26337)
/gene="gidB"
/locus_tag="BCG_0025c"
/db_xref="GeneID:4697549"
CDS complement(25663..26337)
/gene="gidB"
/locus_tag="BCG_0025c"
/note="glucose-inhibited division protein B; SAM-dependent
methyltransferase; methylates the N7 position of guanosine
in position 527 of 16S rRNA"
/codon_start=1
/transl_table=11
/product="16S rRNA methyltransferase GidB"
/protein_id="YP_976128.1"
/db_xref="GI:121635905"
/db_xref="GeneID:4697549"
/translation="MSPIEPAASAIFGPRLGLARRYAEALAGPGVERGLVGPREVGRL
WDRHLLNCAVIGELLERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLR
EMVTDLGVAVEIVRGRAEESWVQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRML
AIKGERAHDEVREHRRVMIASGAVDVRVVTCGANYLRPPATVVFARRGKQIARGSARM
ASGGTA"
misc_feature complement(25756..26295)
/gene="gidB"
/locus_tag="BCG_0025c"
/note="rRNA small subunit methyltransferase G; Region:
GidB; pfam02527"
/db_xref="CDD:217086"
misc_feature complement(25717..26277)
/gene="gidB"
/locus_tag="BCG_0025c"
/note="16S rRNA methyltransferase GidB; Reviewed; Region:
gidB; PRK00107"
/db_xref="CDD:234637"
gene complement(26469..27032)
/locus_tag="BCG_0026c"
/db_xref="GeneID:4697395"
CDS complement(26469..27032)
/locus_tag="BCG_0026c"
/note="Differs from Rv3920c by 1aa, W110R"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976129.1"
/db_xref="GI:121635906"
/db_xref="GeneID:4697395"
/translation="MADADTTDFDVDAEAPGGGVREDTATDADEADDQEERLVAEGEI
AGDYLEELLDVLDFDGDIDLDVEGNRAVVSIDGSDDLNKLVGRGGEVLDALQELTRLA
VHQKTGVWSRLMLDIARWRRRRREELAALADEVARRVAETGDREELVPMTPFERKIVH
DAVAAVPGVHSESEGVEPERRVVVLRD"
misc_feature complement(26472..>26909)
/locus_tag="BCG_0026c"
/note="Predicted RNA-binding protein [General function
prediction only]; Region: Jag; COG1847"
/db_xref="CDD:224760"
misc_feature complement(<26709..26894)
/locus_tag="BCG_0026c"
/note="jag_K homology RNA-binding domain. The KH domain is
found in proteins homologous to the Bacillus subtilis
protein Jag, which is associated with SpoIIIJ and is
necessary for the third stage of sporulation. The KH
motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH;
cd02414"
/db_xref="CDD:239097"
misc_feature complement(26766..26777)
/locus_tag="BCG_0026c"
/note="G-X-X-G motif; other site"
/db_xref="CDD:239097"
misc_feature complement(26475..>26609)
/locus_tag="BCG_0026c"
/note="R3H domain found in proteins homologous to Bacillus
subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is
necessary for the third stage of sporulation. The name of
the R3H domain comes from the characteristic spacing of
the most conserved arginine...; Region: R3H_jag; cd02644"
/db_xref="CDD:100073"
misc_feature complement(order(26553..26555,26565..26567))
/locus_tag="BCG_0026c"
/note="RxxxH motif; other site"
/db_xref="CDD:100073"
gene complement(27104..28204)
/locus_tag="BCG_0027c"
/db_xref="GeneID:4696493"
CDS complement(27104..28204)
/locus_tag="BCG_0027c"
/note="functions to insert inner membrane proteins into
the IM in Escherichia coli; interacts with transmembrane
segments; functions in both Sec-dependent and -independent
membrane insertion; similar to Oxa1p in mitochondria"
/codon_start=1
/transl_table=11
/product="preprotein translocase subunit YidC"
/protein_id="YP_976130.1"
/db_xref="GI:121635907"
/db_xref="GeneID:4696493"
/translation="MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSV
MFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHG
FNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVG
HFLDANLFGAPIGAYMTQRSGLDVFVDFSRPALIAVGVPVMILAGIATYFNSRASIAR
QSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGM
IEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDAST
ERPADTSNPARRNSGPSARTPRPGVRPKKRKR"
misc_feature complement(27374..28168)
/locus_tag="BCG_0027c"
/note="putative inner membrane protein translocase
component YidC; Provisional; Region: PRK03449"
/db_xref="CDD:179580"
gene complement(28188..28550)
/locus_tag="BCG_0028c"
/db_xref="GeneID:4697744"
CDS complement(28188..28550)
/locus_tag="BCG_0028c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976131.1"
/db_xref="GI:121635908"
/db_xref="GeneID:4697744"
/translation="MSLSRQSCGRVVRVTGRASARGLIFVIQVYRHMLSPLRPASCRF
VPTCSQYAVDALTEYGLLRGSWLTMIRLAKCGPWHRGGWDPIPEGLTTGRSCQTDVDG
ANDDWNPASKRGERESFV"
misc_feature complement(28290..28517)
/locus_tag="BCG_0028c"
/note="hypothetical protein; Validated; Region: PRK00041"
/db_xref="CDD:178815"
gene complement(28547..28924)
/gene="rnpA"
/locus_tag="BCG_0029c"
/db_xref="GeneID:4697864"
CDS complement(28547..28924)
/gene="rnpA"
/locus_tag="BCG_0029c"
/EC_number="3.1.26.5"
/note="protein component of RNaseP which catalyzes the
removal of the 5'-leader sequence from pre-tRNA to produce
the mature 5'terminus; this enzyme also cleaves other RNA
substrates"
/codon_start=1
/transl_table=11
/product="ribonuclease P"
/protein_id="YP_976132.1"
/db_xref="GI:121635909"
/db_xref="GeneID:4697864"
/translation="MIATPGLFAVLRARNRMRRSADFETTVKHGMRTVRSDMVVYWWR
GSGGGPRVGLIIAKSVGSAVERHRVARRLRHVAGSIVKELHPSDHVVIRALPSSRHVS
SARLEQQLRCGLRRAVELAGSDR"
misc_feature complement(28550..28894)
/gene="rnpA"
/locus_tag="BCG_0029c"
/note="ribonuclease P; Reviewed; Region: rnpA; PRK00588"
/db_xref="CDD:179073"
gene complement(28921..29064)
/gene="rpmH"
/locus_tag="BCG_0030c"
/db_xref="GeneID:4696318"
CDS complement(28921..29064)
/gene="rpmH"
/locus_tag="BCG_0030c"
/note="in Escherichia coli transcription of this gene is
enhanced by polyamines"
/codon_start=1
/transl_table=11
/product="50S ribosomal protein L34"
/protein_id="YP_976133.1"
/db_xref="GI:121635910"
/db_xref="GeneID:4696318"
/translation="MTKGKRTFQPNNRRRARVHGFRLRMRTRAGRSIVSSRRRKGRRT
LSA"
misc_feature complement(28924..29052)
/gene="rpmH"
/locus_tag="BCG_0030c"
/note="50S ribosomal protein L34; Reviewed; Region: rpmH;
PRK00399"
/db_xref="CDD:179004"
gene 29668..31191
/gene="dnaA"
/locus_tag="BCG_0031"
/db_xref="GeneID:4695799"
CDS 29668..31191
/gene="dnaA"
/locus_tag="BCG_0031"
/note="binds to the dnaA-box as an ATP-bound complex at
the origin of replication during the initiation of
chromosomal replication; can also affect transcription of
multiple genes including itself."
/codon_start=1
/transl_table=11
/product="chromosomal replication initiation protein"
/protein_id="YP_976134.1"
/db_xref="GI:121635911"
/db_xref="GeneID:4695799"
/translation="MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQ
RAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAP
PATDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPRNTDS
ATAGVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLL
HAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFI
EGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPE
LETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDK
ALAEIVLRDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYL
CRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR"
misc_feature 29767..31176
/gene="dnaA"
/locus_tag="BCG_0031"
/note="chromosomal replication initiation protein;
Reviewed; Region: dnaA; PRK00149"
/db_xref="CDD:178902"
misc_feature 30268..30645
/gene="dnaA"
/locus_tag="BCG_0031"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature 30289..30312
/gene="dnaA"
/locus_tag="BCG_0031"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature order(30292..30315,30478..30480,30577..30579)
/gene="dnaA"
/locus_tag="BCG_0031"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature 30466..30483
/gene="dnaA"
/locus_tag="BCG_0031"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature 30616..30618
/gene="dnaA"
/locus_tag="BCG_0031"
/note="arginine finger; other site"
/db_xref="CDD:99707"
misc_feature 30910..31170
/gene="dnaA"
/locus_tag="BCG_0031"
/note="C-terminal domain of bacterial DnaA proteins. The
DNA-binding C-terminal domain of DnaA contains a
helix-turn-helix motif that specifically interacts with
the DnaA box, a 9-mer motif that occurs repetitively in
the replication origin oriC. Multiple...; Region:
Bac_DnaA_C; cd06571"
/db_xref="CDD:119330"
misc_feature order(30973..30975,30997..31002,31021..31023,31039..31047,
31069..31083,31090..31092,31099..31104)
/gene="dnaA"
/locus_tag="BCG_0031"
/note="DnaA box-binding interface [nucleotide binding];
other site"
/db_xref="CDD:119330"
gene 31719..32927
/gene="dnaN_2"
/locus_tag="BCG_0032"
/db_xref="GeneID:4696807"
CDS 31719..32927
/gene="dnaN_2"
/locus_tag="BCG_0032"
/EC_number="2.7.7.7"
/note="binds the polymerase to DNA and acts as a sliding
clamp"
/codon_start=1
/transl_table=11
/product="DNA polymerase III subunit beta"
/protein_id="YP_976135.1"
/db_xref="GI:121635912"
/db_xref="GeneID:4696807"
/translation="MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSG
VLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVGVHV
EGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDT
LPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAG
IGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMD
VAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIA
FNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYV
YLLMPVRLPG"
misc_feature 31761..32924
/gene="dnaN_2"
/locus_tag="BCG_0032"
/note="DNA polymerase III subunit beta; Validated; Region:
PRK07761"
/db_xref="CDD:181105"
misc_feature 31761..32915
/gene="dnaN_2"
/locus_tag="BCG_0032"
/note="Beta clamp domain. The beta subunit (processivity
factor) of DNA polymerase III holoenzyme, refered to as
the beta clamp, forms a ring shaped dimer that encircles
dsDNA (sliding clamp) in bacteria. The beta-clamp is
structurally similar to the trimeric...; Region:
beta_clamp; cd00140"
/db_xref="CDD:29053"
misc_feature order(31824..31826,31968..31970,31989..31991,32343..32345)
/gene="dnaN_2"
/locus_tag="BCG_0032"
/note="putative DNA binding surface [nucleotide binding];
other site"
/db_xref="CDD:29053"
misc_feature order(31971..31973,31980..31982,32055..32057,32061..32063,
32583..32585,32673..32678)
/gene="dnaN_2"
/locus_tag="BCG_0032"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:29053"
misc_feature order(32259..32261,32265..32276,32724..32726,32904..32915)
/gene="dnaN_2"
/locus_tag="BCG_0032"
/note="beta-clamp/clamp loader binding surface; other
site"
/db_xref="CDD:29053"
misc_feature order(32259..32261,32265..32270,32508..32510,32610..32612,
32649..32654,32733..32735,32904..32915)
/gene="dnaN_2"
/locus_tag="BCG_0032"
/note="beta-clamp/translesion DNA polymerase binding
surface; other site"
/db_xref="CDD:29053"
gene 32947..34104
/gene="recF"
/locus_tag="BCG_0033"
/db_xref="GeneID:4697933"
CDS 32947..34104
/gene="recF"
/locus_tag="BCG_0033"
/note="Required for DNA replication; binds preferentially
to single-stranded, linear DNA"
/codon_start=1
/transl_table=11
/product="recombination protein F"
/protein_id="YP_976136.1"
/db_xref="GI:121635913"
/db_xref="GeneID:4697933"
/translation="MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALW
YSTTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSV
RSTRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVVRQ
RTALLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQL
LAPESRSASIGYRASMDVTGPSEQSDTDRQLLAARLLAALAARRDAELERGVCLVGPH
RDDLILRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVM
RRRALATAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP"
misc_feature 32947..34086
/gene="recF"
/locus_tag="BCG_0033"
/note="recF protein; Region: recf; TIGR00611"
/db_xref="CDD:233051"
misc_feature 32953..>33444
/gene="recF"
/locus_tag="BCG_0033"
/note="ATP-binding cassette domain of RecF; Region:
ABC_RecF; cd03242"
/db_xref="CDD:213209"
misc_feature 33034..33057
/gene="recF"
/locus_tag="BCG_0033"
/note="Walker A/P-loop; other site"
/db_xref="CDD:213209"
misc_feature order(33043..33048,33052..33060,33250..33252)
/gene="recF"
/locus_tag="BCG_0033"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:213209"
misc_feature 33241..33252
/gene="recF"
/locus_tag="BCG_0033"
/note="Q-loop/lid; other site"
/db_xref="CDD:213209"
misc_feature <33760..34089
/gene="recF"
/locus_tag="BCG_0033"
/note="ATP-binding cassette transporter nucleotide-binding
domain; Region: ABC_ATPase; cl17201"
/db_xref="CDD:247755"
misc_feature 33823..33852
/gene="recF"
/locus_tag="BCG_0033"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:213179"
misc_feature 33907..33924
/gene="recF"
/locus_tag="BCG_0033"
/note="Walker B; other site"
/db_xref="CDD:213179"
misc_feature 33931..33942
/gene="recF"
/locus_tag="BCG_0033"
/note="D-loop; other site"
/db_xref="CDD:213179"
misc_feature 33997..34017
/gene="recF"
/locus_tag="BCG_0033"
/note="H-loop/switch region; other site"
/db_xref="CDD:213179"
gene 34101..34664
/locus_tag="BCG_0034"
/db_xref="GeneID:4696083"
CDS 34101..34664
/locus_tag="BCG_0034"
/note="Differs from Mb0004 by 1aa, S16L"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976137.1"
/db_xref="GI:121635914"
/db_xref="GeneID:4696083"
/translation="MTGSVDRPDQNRGERSMKSPGLDLVRRTLDEARAAARARGQDAG
RGRVASVASGRVAGRRRSWSGPGPDIRDPQPLGKAARELAKKRGWSVRVAEGMVLGQW
SAVVGHQIAEHARPTALNDGVLSVIAESTAWATQLRIMQAQLLAKIAAAVGNDVVRSL
KITGPAAPSWRKGPRHIAGRGPRDTYG"
misc_feature 34104..34661
/locus_tag="BCG_0034"
/note="hypothetical protein; Provisional; Region:
PRK03195"
/db_xref="CDD:179552"
gene 34790..36934
/gene="gyrB"
/locus_tag="BCG_0035"
/db_xref="GeneID:4696763"
CDS 34790..36934
/gene="gyrB"
/locus_tag="BCG_0035"
/EC_number="5.99.1.3"
/note="negatively supercoils closed circular
double-stranded DNA"
/codon_start=1
/transl_table=11
/product="DNA gyrase subunit B"
/protein_id="YP_976138.1"
/db_xref="GI:121635915"
/db_xref="GeneID:4696763"
/translation="MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQK
KKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYAT
TVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLH
GVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAV
FETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERA
AESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNA
GYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREG
LAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDSKVVVNKAV
SSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKS
GRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKI
VLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDR
ERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAA
ADELFSILMGEDVDARRSFITRNAKDVRFLDV"
misc_feature 34919..36931
/gene="gyrB"
/locus_tag="BCG_0035"
/note="DNA gyrase subunit B; Validated; Region: gyrB;
PRK05644"
/db_xref="CDD:180181"
misc_feature 35030..>35176
/gene="gyrB"
/locus_tag="BCG_0035"
/note="Histidine kinase-like ATPases; This family includes
several ATP-binding proteins for example: histidine
kinase, DNA gyrase B, topoisomerases, heat shock protein
HSP90, phytochrome-like ATPases and DNA mismatch repair
proteins; Region: HATPase_c; cd00075"
/db_xref="CDD:28956"
misc_feature 35060..35062
/gene="gyrB"
/locus_tag="BCG_0035"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28956"
misc_feature order(35147..35149,35153..35155)
/gene="gyrB"
/locus_tag="BCG_0035"
/note="G-X-G motif; other site"
/db_xref="CDD:28956"
misc_feature 35669..36184
/gene="gyrB"
/locus_tag="BCG_0035"
/note="TopoIIA_Trans_DNA_gyrase: Transducer domain, having
a ribosomal S5 domain 2-like fold, of the type found in
proteins of the type IIA family of DNA topoisomerases
similar to the B subunits of E. coli DNA gyrase and E.
coli Topoisomerase IV which are; Region:
TopoII_Trans_DNA_gyrase; cd00822"
/db_xref="CDD:48467"
misc_feature 35822..35824
/gene="gyrB"
/locus_tag="BCG_0035"
/note="anchoring element; other site"
/db_xref="CDD:48467"
misc_feature order(35996..35998,36005..36010,36014..36016,36149..36154,
36164..36166,36176..36178)
/gene="gyrB"
/locus_tag="BCG_0035"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:48467"
misc_feature order(36014..36016,36020..36022)
/gene="gyrB"
/locus_tag="BCG_0035"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:48467"
misc_feature 36263..36604
/gene="gyrB"
/locus_tag="BCG_0035"
/note="TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM)
nucleotidyl transferase/hydrolase domain of the type found
in proteins of the type IIA family of DNA topoisomerases
similar to the Escherichia coli GyrB subunit. TopoIIA
enzymes cut both strands of the...; Region:
TOPRIM_TopoIIA_GyrB; cd03366"
/db_xref="CDD:173786"
misc_feature order(36281..36286,36293..36295,36500..36502,36506..36508,
36512..36514)
/gene="gyrB"
/locus_tag="BCG_0035"
/note="active site"
/db_xref="CDD:173786"
misc_feature order(36281..36283,36500..36502)
/gene="gyrB"
/locus_tag="BCG_0035"
/note="putative metal-binding site [ion binding]; other
site"
/db_xref="CDD:173786"
misc_feature 36692..36895
/gene="gyrB"
/locus_tag="BCG_0035"
/note="DNA gyrase B subunit, carboxyl terminus; Region:
DNA_gyraseB_C; pfam00986"
/db_xref="CDD:201537"
gene 36969..39485
/gene="gyrA_2"
/locus_tag="BCG_0036"
/db_xref="GeneID:4695443"
CDS 36969..39485
/gene="gyrA_2"
/locus_tag="BCG_0036"
/EC_number="5.99.1.3"
/note="negatively supercoils closed circular
double-stranded DNA"
/codon_start=1
/transl_table=11
/product="DNA gyrase subunit A"
/protein_id="YP_976139.1"
/db_xref="GI:121635916"
/db_xref="GeneID:4695443"
/translation="MTDTTLPPDDSLDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEV
RDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQP
WSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRV
QEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAA
VMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPY
QVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKH
TQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILR
GLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQR
IIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDE
DLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDL
ILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLV
LATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSADDDLLLVSANGQSIR
FSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEY
PVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQT
KGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN"
misc_feature 37008..39431
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA gyrase subunit A; Validated; Region: PRK05560"
/db_xref="CDD:235502"
misc_feature 37077..38426
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA Topoisomerase, subtype IIA; domain A';
bacterial DNA topoisomerase IV (C subunit, ParC),
bacterial DNA gyrases (A subunit, GyrA),mammalian DNA
toposiomerases II. DNA topoisomerases are essential
enzymes that regulate the conformational changes...;
Region: TOP4c; cd00187"
/db_xref="CDD:238111"
misc_feature order(37077..37160,37173..37322,37326..37382,37386..37457,
37464..37466)
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="CAP-like domain; other site"
/db_xref="CDD:238111"
misc_feature 37353..37355
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="active site"
/db_xref="CDD:238111"
misc_feature order(38163..38171,38178..38189,38220..38225,38265..38315)
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="primary dimer interface [polypeptide binding];
other site"
/db_xref="CDD:238111"
misc_feature 38511..38654
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 38661..38813
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 38832..38966
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 38973..39122
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 39132..39275
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
misc_feature 39285..39419
/gene="gyrA_2"
/locus_tag="BCG_0036"
/note="DNA gyrase C-terminal domain, beta-propeller;
Region: DNA_gyraseA_C; pfam03989"
/db_xref="CDD:217832"
gene 39581..40495
/locus_tag="BCG_0037"
/db_xref="GeneID:4695441"
CDS 39581..40495
/locus_tag="BCG_0037"
/note="Differs from Rv0007 by 1aa, I272V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976140.1"
/db_xref="GI:121635917"
/db_xref="GeneID:4695441"
/translation="MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPP
PWQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADARLNRFISGASAPVTGPAAAVRT
PQPDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAG
SSGGRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMI
TVAFLYLVLGGMGVWAKLNSNVGDLLNNASGSSAELVSSGTIFGGAFLIGLVNIVLMT
ALATIGAFVYNLITDLIGGIEVTLADRD"
misc_feature 40133..40489
/locus_tag="BCG_0037"
/note="Transmembrane domain of unknown function (DUF3566);
Region: DUF3566; pfam12089"
/db_xref="CDD:152524"
gene 40554..40627
/gene="tRNA-Ile"
/locus_tag="BCG_ileT_2"
/db_xref="GeneID:4697762"
tRNA 40554..40627
/gene="tRNA-Ile"
/locus_tag="BCG_ileT_2"
/product="tRNA-Ile"
/note="ileT_2, len: 74 nt. Second of two copies equivalent
to ileT, len: 74 nt, from Mycobacterium tuberculosis
strain H37Rv, (100.0% identity in 74 nt overlap).
tRNA-Ile, anticodon gat"
/anticodon=(pos:40588..40590,aa:Ile,seq:gat)
/codon_recognized="AUC"
/db_xref="GeneID:4697762"
gene 40779..40851
/gene="tRNA-Ala"
/locus_tag="BCG_alaT_2"
/db_xref="GeneID:4696333"
tRNA 40779..40851
/gene="tRNA-Ala"
/locus_tag="BCG_alaT_2"
/product="tRNA-Ala"
/note="alaT_2, len: 73 nt. Second of two copies equivalent
to alaT, len: 73 nt, from Mycobacterium tuberculosis
strain H37Rv, (100.0% identity in 73 nt overlap).
tRNA-Ala, anticodon tgc"
/anticodon=(pos:40812..40814,aa:Ala,seq:tgc)
/codon_recognized="GCA"
/db_xref="GeneID:4696333"
gene complement(41541..41978)
/locus_tag="BCG_0038c"
/db_xref="GeneID:4697079"
CDS complement(41541..41978)
/locus_tag="BCG_0038c"
/note="Differs from Rv0008c by 1aa, P145S"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976141.1"
/db_xref="GI:121635918"
/db_xref="GeneID:4697079"
/translation="MSEQVETRLTPRERLTRGLAYSAVGPVDVTRGLLELGVGLGLQS
ARSTAAGLRRRYREGRLAREVAAAQETLAQELTAAQDVVANLPQALQDARTQRRSKHH
LWIFAGIAAAILAGGAVAFSIVRRSSRPEPSPRPPSVEVQPRP"
misc_feature complement(<41667..41927)
/locus_tag="BCG_0038c"
/note="Protein of unknown function (DUF2562); Region:
DUF2562; pfam10814"
/db_xref="CDD:151264"
gene 42135..42683
/gene="ppiA_2"
/locus_tag="BCG_0039"
/db_xref="GeneID:4698839"
CDS 42135..42683
/gene="ppiA_2"
/locus_tag="BCG_0039"
/EC_number="5.2.1.8"
/standard_name="cfp22"
/codon_start=1
/transl_table=11
/product="iron-regulated peptidyl-prolyl cis-trans
isomerase a ppiA"
/protein_id="YP_976142.1"
/db_xref="GI:121635919"
/db_xref="GeneID:4698839"
/translation="MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVG
LAQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFH
PELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAIS
KTATDGNDRPTDPVVIESITIS"
misc_feature 42186..42668
/gene="ppiA_2"
/locus_tag="BCG_0039"
/note="cyclophilin: cyclophilin-type peptidylprolyl cis-
trans isomerases. This family contains eukaryotic,
bacterial and archeal proteins which exhibit a
peptidylprolyl cis- trans isomerases activity (PPIase,
Rotamase) and in addition bind the...; Region:
cyclophilin; cd00317"
/db_xref="CDD:238194"
misc_feature order(42351..42353,42357..42359,42366..42371,42375..42377,
42480..42485,42510..42512,42516..42518,42540..42545,
42555..42557)
/gene="ppiA_2"
/locus_tag="BCG_0039"
/note="active site"
/db_xref="CDD:238194"
gene complement(42889..43224)
/locus_tag="BCG_0040c"
/db_xref="GeneID:4698100"
CDS complement(42889..43224)
/locus_tag="BCG_0040c"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a single base deletion (g-*) leads to
a shorter product compared to its homolog in Mycobacterium
tuberculosis strain H37Rv (111 aa versus 141 aa)"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976143.1"
/db_xref="GI:121635920"
/db_xref="GeneID:4698100"
/translation="MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAA
LGLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLL
EIETVSGGC"
misc_feature complement(<42931..43053)
/locus_tag="BCG_0040c"
/note="Protein of unknown function (DUF2581); Region:
DUF2581; pfam10756"
/db_xref="CDD:204551"
gene complement(43380..43661)
/locus_tag="BCG_0041c"
/db_xref="GeneID:4695661"
CDS complement(43380..43661)
/locus_tag="BCG_0041c"
/note="integral membrane protein involved in inhibition of
the Z-ring formation"
/codon_start=1
/transl_table=11
/product="septation inhibitor protein"
/protein_id="YP_976144.1"
/db_xref="GI:121635921"
/db_xref="GeneID:4695661"
/translation="MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIG
LIWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH"
misc_feature complement(43383..43661)
/locus_tag="BCG_0041c"
/note="putative septation inhibitor protein; Reviewed;
Region: PRK00159"
/db_xref="CDD:178907"
gene 43755..44543
/locus_tag="BCG_0042"
/db_xref="GeneID:4698560"
CDS 43755..44543
/locus_tag="BCG_0042"
/note="Differs from Rv0012 by 2aa, E105K, R233C"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976145.1"
/db_xref="GI:121635922"
/db_xref="GeneID:4698560"
/translation="MRLTHPTPCPENGETMIDRRRSAWRFSVPLVCLLAGLLLAATHG
VSGGTEIRRSDAPRLVDLVRRAQASVNRLATEREALTTRIDSVHGRSVDTALAAMQRR
SAELAGVAAMNPVHGPGLVVTLQDAQRDANGRFPRDASPDDLVVHQQDIEAVLNALWN
AGAEAIQMQDQRIIAMSIARCVGNTLLLNGRTYSPPYTIAAIGDAAAMQAALAAAPLV
TLYKQYVVRFGLGYREEVHPDLQIVGYADPVRMHFAQPAGPLDY"
misc_feature 43764..44531
/locus_tag="BCG_0042"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG3879"
/db_xref="CDD:33668"
misc_feature 44052..44525
/locus_tag="BCG_0042"
/note="Bacterial protein of unknown function (DUF881);
Region: DUF881; pfam05949"
/db_xref="CDD:191409"
gene 44580..45278
/gene="trpG_2"
/locus_tag="BCG_0043"
/db_xref="GeneID:4695708"
CDS 44580..45278
/gene="trpG_2"
/locus_tag="BCG_0043"
/note="aminodeoxychorismate synthase subunit PabA; with
PabB catalyzes the formation of 4-amino-4-deoxychorismate
from chorismate and glutamine in para-aminobenzoate
synthesis; PabA provides the glutamine amidotransferase
activity"
/codon_start=1
/transl_table=11
/product="para-aminobenzoate synthase component II"
/protein_id="YP_976146.1"
/db_xref="GI:121635923"
/db_xref="GeneID:4695708"
/translation="MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVA
GQFDGVLLSPGPGTPERAGASVSMVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPE
LLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQ
HTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPT
STASAGEATGRTSA"
misc_feature 44586..45146
/gene="trpG_2"
/locus_tag="BCG_0043"
/note="Type 1 glutamine amidotransferase (GATase1) domain
found in Anthranilate synthase; Region:
GATase1_Anthranilate_Synthase; cd01743"
/db_xref="CDD:153214"
misc_feature 44589..45146
/gene="trpG_2"
/locus_tag="BCG_0043"
/note="Glutamine amidotransferase class-I; Region: GATase;
pfam00117"
/db_xref="CDD:215729"
misc_feature order(44739..44744,44748..44750,44826..44831,44838..44840,
44970..44981)
/gene="trpG_2"
/locus_tag="BCG_0043"
/note="glutamine binding [chemical binding]; other site"
/db_xref="CDD:153214"
misc_feature order(44826..44828,45093..45095,45099..45101)
/gene="trpG_2"
/locus_tag="BCG_0043"
/note="catalytic triad [active]"
/db_xref="CDD:153214"
gene complement(45256..47136)
/gene="pknB"
/locus_tag="BCG_0044c"
/db_xref="GeneID:4695829"
CDS complement(45256..47136)
/gene="pknB"
/locus_tag="BCG_0044c"
/EC_number="2.7.1.-"
/codon_start=1
/transl_table=11
/product="Ser/Thr protein kinase"
/protein_id="YP_976147.1"
/db_xref="GI:121635924"
/db_xref="GeneID:4695829"
/translation="MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRA
DLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD
IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIA
RAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG
DSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRV
HNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVA
VVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDS
TIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFG
RFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVA
QKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDL
SGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRF
GQ"
misc_feature complement(46321..47106)
/gene="pknB"
/locus_tag="BCG_0044c"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:214567"
misc_feature complement(46513..47088)
/gene="pknB"
/locus_tag="BCG_0044c"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature complement(order(46594..46605,46660..46662,46669..46671,
46702..46704,46708..46713,46717..46719,46723..46725,
46834..46836,46840..46842,46852..46863,46921..46923,
47017..47019,47023..47025,47062..47064,47074..47088))
/gene="pknB"
/locus_tag="BCG_0044c"
/note="active site"
/db_xref="CDD:173623"
misc_feature complement(order(46669..46671,46702..46704,46708..46713,
46717..46719,46723..46725,46840..46842,46852..46863,
46921..46923,47017..47019,47023..47025,47062..47064,
47074..47088))
/gene="pknB"
/locus_tag="BCG_0044c"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature complement(order(46594..46605,46660..46662,46711..46713,
46717..46719,46723..46725,46834..46836,46840..46842,
47074..47076))
/gene="pknB"
/locus_tag="BCG_0044c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature complement(order(46594..46605,46654..46674))
/gene="pknB"
/locus_tag="BCG_0044c"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature complement(45259..46062)
/gene="pknB"
/locus_tag="BCG_0044c"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG2815"
/db_xref="CDD:225372"
misc_feature complement(45874..46056)
/gene="pknB"
/locus_tag="BCG_0044c"
/note="PASTA domain of bacterial serine/threonine kinase
pknB-like proteins. PknB is a member of a group of related
transmembrane sensor kinases present in many gram positive
bacteria, which has been shown to regulate cell shape in
Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577"
/db_xref="CDD:119328"
misc_feature complement(45673..45855)
/gene="pknB"
/locus_tag="BCG_0044c"
/note="PASTA domain of bacterial serine/threonine kinase
pknB-like proteins. PknB is a member of a group of related
transmembrane sensor kinases present in many gram positive
bacteria, which has been shown to regulate cell shape in
Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577"
/db_xref="CDD:119328"
misc_feature complement(45469..45648)
/gene="pknB"
/locus_tag="BCG_0044c"
/note="PASTA domain of bacterial serine/threonine kinase
pknB-like proteins. PknB is a member of a group of related
transmembrane sensor kinases present in many gram positive
bacteria, which has been shown to regulate cell shape in
Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577"
/db_xref="CDD:119328"
misc_feature complement(45271..45453)
/gene="pknB"
/locus_tag="BCG_0044c"
/note="PASTA domain of bacterial serine/threonine kinase
pknB-like proteins. PknB is a member of a group of related
transmembrane sensor kinases present in many gram positive
bacteria, which has been shown to regulate cell shape in
Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577"
/db_xref="CDD:119328"
gene complement(47133..48428)
/gene="pknA"
/locus_tag="BCG_0045c"
/db_xref="GeneID:4696549"
CDS complement(47133..48428)
/gene="pknA"
/locus_tag="BCG_0045c"
/EC_number="2.7.1.-"
/codon_start=1
/transl_table=11
/product="Ser/Thr protein kinase"
/protein_id="YP_976148.1"
/db_xref="GI:121635925"
/db_xref="GeneID:4696549"
/translation="MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVL
KSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEP
LNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDF
GIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFA
GDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRA
GRRPPRPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFS
SGQRALLWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDA
SPRLNWTERGETRHSGLQSWVVPPTPHSRASLARYEIAQ"
misc_feature complement(47646..48392)
/gene="pknA"
/locus_tag="BCG_0045c"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:214567"
misc_feature complement(47802..48374)
/gene="pknA"
/locus_tag="BCG_0045c"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature complement(order(47883..47894,47943..47945,47952..47954,
47985..47987,47991..47996,48000..48002,48006..48008,
48117..48119,48123..48125,48135..48146,48207..48209,
48303..48305,48309..48311,48348..48350,48360..48374))
/gene="pknA"
/locus_tag="BCG_0045c"
/note="active site"
/db_xref="CDD:173623"
misc_feature complement(order(47952..47954,47985..47987,47991..47996,
48000..48002,48006..48008,48123..48125,48135..48146,
48207..48209,48303..48305,48309..48311,48348..48350,
48360..48374))
/gene="pknA"
/locus_tag="BCG_0045c"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature complement(order(47883..47894,47943..47945,47994..47996,
48000..48002,48006..48008,48117..48119,48123..48125,
48360..48362))
/gene="pknA"
/locus_tag="BCG_0045c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature complement(order(47883..47894,47937..47957))
/gene="pknA"
/locus_tag="BCG_0045c"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
gene complement(48425..49900)
/gene="pbpA"
/locus_tag="BCG_0046c"
/db_xref="GeneID:4699308"
CDS complement(48425..49900)
/gene="pbpA"
/locus_tag="BCG_0046c"
/codon_start=1
/transl_table=11
/product="penicillin-binding protein pbpA"
/protein_id="YP_976149.1"
/db_xref="GI:121635926"
/db_xref="GeneID:4699308"
/translation="MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVL
LDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALER
AEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKG
AVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETY
PPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLRE
AFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGM
TSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVS
PQVAAKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQ
APKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQGEP"
misc_feature complement(48431..>49804)
/gene="pbpA"
/locus_tag="BCG_0046c"
/note="Cell division protein FtsI/penicillin-binding
protein 2 [Cell envelope biogenesis, outer membrane];
Region: FtsI; COG0768"
/db_xref="CDD:31111"
misc_feature complement(48449..49423)
/gene="pbpA"
/locus_tag="BCG_0046c"
/note="Penicillin binding protein transpeptidase domain;
Region: Transpeptidase; pfam00905"
/db_xref="CDD:144486"
gene complement(49897..51306)
/gene="rodA"
/locus_tag="BCG_0047c"
/db_xref="GeneID:4698833"
CDS complement(49897..51306)
/gene="rodA"
/locus_tag="BCG_0047c"
/codon_start=1
/transl_table=11
/product="cell division protein rodA"
/protein_id="YP_976150.1"
/db_xref="GI:121635927"
/db_xref="GeneID:4698833"
/translation="MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQ
DQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLV
DNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPA
LLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGM
TLPRPRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTL
FAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQP
DTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLS
STLAIQLFIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRT
RPRNKSPITAAGTEVIERV"
misc_feature complement(50029..51024)
/gene="rodA"
/locus_tag="BCG_0047c"
/note="Bacterial cell division membrane protein [Cell
division and chromosome partitioning]; Region: FtsW;
COG0772"
/db_xref="CDD:223843"
gene complement(51303..52847)
/gene="pstP"
/locus_tag="BCG_0048c"
/db_xref="GeneID:4697710"
CDS complement(51303..52847)
/gene="pstP"
/locus_tag="BCG_0048c"
/EC_number="3.1.3.16"
/note="Differs from Rv0018c by 3aa, L3R, A455S, S463P"
/codon_start=1
/transl_table=11
/product="Serine/threonine phosphatase PPP"
/protein_id="YP_976151.1"
/db_xref="GI:121635928"
/db_xref="GeneID:4697710"
/translation="MALVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHA
AGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLT
AILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRS
LIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRL
IELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQ
RKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAG
SVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPE
RAQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVT
SSPAAPSPTTSASAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGI
DCRAAA"
misc_feature complement(52164..52823)
/gene="pstP"
/locus_tag="BCG_0048c"
/note="Serine/threonine phosphatases, family 2C, catalytic
domain; The protein architecture and deduced catalytic
mechanism of PP2C phosphatases are similar to the PP1,
PP2A, PP2B family of protein Ser/Thr phosphatases, with
which PP2C shares no sequence...; Region: PP2Cc; cd00143"
/db_xref="CDD:238083"
misc_feature complement(order(52275..52277,52728..52736,52773..52778,
52788..52790))
/gene="pstP"
/locus_tag="BCG_0048c"
/note="active site"
/db_xref="CDD:238083"
gene complement(52936..53403)
/locus_tag="BCG_0049c"
/db_xref="GeneID:4695696"
CDS complement(52936..53403)
/locus_tag="BCG_0049c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976152.1"
/db_xref="GI:121635929"
/db_xref="GeneID:4695696"
/translation="MQGLVLQLTRAGFLMLLWVFIWSVLRILKTDIYAPTGAVMMRRG
LALRGTLLGARQRRHAARYLVVTEGALTGARITLSEQPVLIGRADDSTLVLTDDYAST
RHARLSMRGSEWYVEDLGSTNGTYLDRAKVTTAVRVPIGTPVRIGKTAIELRP"
misc_feature complement(52948..53403)
/locus_tag="BCG_0049c"
/note="FOG: FHA domain [Signal transduction mechanisms];
Region: COG1716"
/db_xref="CDD:224630"
misc_feature complement(52942..53217)
/locus_tag="BCG_0049c"
/note="Forkhead associated domain (FHA); found in
eukaryotic and prokaryotic proteins. Putative nuclear
signalling domain. FHA domains may bind phosphothreonine,
phosphoserine and sometimes phosphotyrosine. In
eukaryotes, many FHA domain-containing proteins...;
Region: FHA; cd00060"
/db_xref="CDD:238017"
misc_feature complement(order(53032..53040,53098..53103,53107..53109,
53143..53145))
/locus_tag="BCG_0049c"
/note="phosphopeptide binding site; other site"
/db_xref="CDD:238017"
gene complement(53527..55092)
/gene="TB39.8"
/locus_tag="BCG_0050c"
/db_xref="GeneID:4697326"
CDS complement(53527..55092)
/gene="TB39.8"
/locus_tag="BCG_0050c"
/note="Differs from Mb0020c by 2aa, G47R, Y250H, and from
Rv0020c by 3aa, G222D, C298Y, Q378R, and deletion of 6aa
(EQRGYP) at position 246"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976153.1"
/db_xref="GI:121635930"
/db_xref="GeneID:4697326"
/translation="MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREA
ADGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGWQTYG
DVVVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNS
SYRGGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRP
RHPGQGDYPEQIGYPDQGGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYEQRPPVS
PGPAAGYGAPGYDQGYRQSGGCGPSPGGGQPGYGGYGEYGRGPARHEEGSYVPSGPPG
PPEQRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYTRYTESPQVPGYAPQGGGYAEP
AGRDYDYGQSGAPDYGQPAPGGYSGYGQGGYGSAGTSVTLQLDDGSGRTYQLREGSNI
IGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDV
IRLGHSEIIVRMH"
misc_feature complement(54724..55071)
/gene="TB39.8"
/locus_tag="BCG_0050c"
/note="Protein of unknown function (DUF2662); Region:
DUF3662; pfam12401"
/db_xref="CDD:204906"
misc_feature complement(53536..53790)
/gene="TB39.8"
/locus_tag="BCG_0050c"
/note="Forkhead associated domain (FHA); found in
eukaryotic and prokaryotic proteins. Putative nuclear
signalling domain. FHA domains may bind phosphothreonine,
phosphoserine and sometimes phosphotyrosine. In
eukaryotes, many FHA domain-containing proteins...;
Region: FHA; cd00060"
/db_xref="CDD:28942"
misc_feature complement(53533..>53766)
/gene="TB39.8"
/locus_tag="BCG_0050c"
/note="FOG: FHA domain [Signal transduction mechanisms];
Region: COG1716"
/db_xref="CDD:31902"
misc_feature complement(order(53623..53631,53689..53694,53698..53700,
53734..53736))
/gene="TB39.8"
/locus_tag="BCG_0050c"
/note="phosphopeptide binding site; other site"
/db_xref="CDD:28942"
gene 55292..55374
/gene="tRNA-Leu"
/locus_tag="BCG_t01"
/db_xref="GeneID:4696424"
tRNA 55292..55374
/gene="tRNA-Leu"
/locus_tag="BCG_t01"
/product="tRNA-Leu"
/note="leuT, len: 83 nt. Equivalent to leuT, len: 83 nt,
from Mycobacterium tuberculosis strain H37Rv, (100.0%
identity in 83 nt overlap). tRNA-Leu, anticodon cag"
/anticodon=(pos:55325..55327,aa:Leu,seq:cag)
/codon_recognized="CUG"
/db_xref="GeneID:4696424"
gene complement(55561..56529)
/locus_tag="BCG_0051c"
/db_xref="GeneID:4696748"
CDS complement(55561..56529)
/locus_tag="BCG_0051c"
/note="Differs from Rv0021c by 1aa, P277A"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976154.1"
/db_xref="GI:121635931"
/db_xref="GeneID:4696748"
/translation="MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIG
GGYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVF
ADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVD
LVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLA
ATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAV
PARDYSIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV"
misc_feature complement(55597..56520)
/locus_tag="BCG_0051c"
/note="Nitronate monooxygenase; Region: NMO; pfam03060"
/db_xref="CDD:217344"
misc_feature complement(55837..56493)
/locus_tag="BCG_0051c"
/note="2-Nitropropane dioxygenase (NPD), one of the
nitroalkane oxidizing enzyme families, catalyzes oxidative
denitrification of nitroalkanes to their corresponding
carbonyl compounds and nitrites. NDP is a member of the
NAD(P)H-dependent flavin oxidoreductase...; Region:
NPD_like; cd04730"
/db_xref="CDD:240081"
misc_feature complement(order(55936..55947,56002..56010,56104..56109,
56119..56121,56182..56184,56245..56247,56320..56322,
56464..56469))
/locus_tag="BCG_0051c"
/note="FMN binding site [chemical binding]; other site"
/db_xref="CDD:240081"
misc_feature complement(56098..56103)
/locus_tag="BCG_0051c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:240081"
misc_feature complement(56098..56100)
/locus_tag="BCG_0051c"
/note="putative catalytic residue [active]"
/db_xref="CDD:240081"
gene complement(56671..57090)
/gene="whiB5"
/locus_tag="BCG_0052c"
/db_xref="GeneID:4698046"
CDS complement(56671..57090)
/gene="whiB5"
/locus_tag="BCG_0052c"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein whiB-like
whiB5"
/protein_id="YP_976155.1"
/db_xref="GI:121635932"
/db_xref="GeneID:4698046"
/translation="MAHPCATDPELWFGYPDDDGSDGAAKARAYERSATQARIQCLRR
CPLLQQRRCAQHAVEHRVEYGVWAGIKLPGGQYRKREQLAAAHDVLRRIAGGEINSRQ
LPDNAALLARNEGLEVTPVPGVVVHLPIAQVGPQPAA"
misc_feature complement(56842..57057)
/gene="whiB5"
/locus_tag="BCG_0052c"
/note="Transcription factor WhiB; Region: Whib; pfam02467"
/db_xref="CDD:111373"
gene 57243..58013
/locus_tag="BCG_0053"
/db_xref="GeneID:4697344"
CDS 57243..58013
/locus_tag="BCG_0053"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976156.1"
/db_xref="GI:121635933"
/db_xref="GeneID:4697344"
/translation="MSRESAGAAIRALRESRDWSLADLAAATGVSTMGLSYLERGARK
PHKSTVQKVENGLGLPPGTYSRLLVAADPDAELARLIAAQPSNPTAVRRAGAVVVDRH
SDTDVLEGYAEAQLDAIKSVIDRLPATTSNEYETYILSVIAQCVKAEMLAASSWRVAV
NAGADSTGRLMEHLRALEATRGALLERMPTSLSARFDRACAQSSLPEAVVAALIGVGA
DEMWDIRNRGVIPAGALPRVRAFVDAIEASHDADEGQQ"
misc_feature 57261..>57482
/locus_tag="BCG_0053"
/note="Predicted transcriptional regulators
[Transcription]; Region: HipB; COG1396"
/db_xref="CDD:224314"
misc_feature 57261..57425
/locus_tag="BCG_0053"
/note="Helix-turn-helix XRE-family like proteins.
Prokaryotic DNA binding proteins belonging to the
xenobiotic response element family of transcriptional
regulators; Region: HTH_XRE; cd00093"
/db_xref="CDD:238045"
misc_feature order(57273..57275,57285..57287,57360..57362)
/locus_tag="BCG_0053"
/note="non-specific DNA binding site [nucleotide binding];
other site"
/db_xref="CDD:238045"
misc_feature order(57282..57284,57357..57359)
/locus_tag="BCG_0053"
/note="salt bridge; other site"
/db_xref="CDD:238045"
misc_feature order(57303..57308,57339..57341,57348..57350,57360..57365)
/locus_tag="BCG_0053"
/note="sequence-specific DNA binding site [nucleotide
binding]; other site"
/db_xref="CDD:238045"
gene 58010..58843
/locus_tag="BCG_0054"
/db_xref="GeneID:4697145"
CDS 58010..58843
/locus_tag="BCG_0054"
/note="In Mycobacterium tuberculosis strain H37Rv, and
other mycobacteria, Rv0024 exists as a single gene. In
Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis,
a frameshift due to a single base deletion (c-*) splits
Rv0024 into 2 parts"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976157.1"
/db_xref="GI:121635934"
/db_xref="GeneID:4697145"
/translation="MNYSEVELLSRAHQLFAGDSRRPGLDAGTTPYGDLLSRAADLNV
GAGQRRYQLAVDHSRAALLSAARTDAAAGAVITGAQRDRAWARRSTGTVLDEARSDTT
VTAVMPIAQREAIRRRVARLRAQRAHVLTARRRARRHLAALRALRYRVAHGPGVALAK
LRLPSPSGRAGIAVHAALSRLGRPYVWGATGPTSSTVPVWSSGPTPRRVFTWIAPPIN
RSTRGSRCRAHRSGRAIWSSRTPGTCSWRSATIWSSRRPMRARRFGSARWATTCRFGD
R"
gene 58585..58854
/locus_tag="BCG_0055"
/pseudo
/db_xref="GeneID:4698692"
gene 58892..59254
/locus_tag="BCG_0056"
/db_xref="GeneID:4696316"
CDS 58892..59254
/locus_tag="BCG_0056"
/note="Differs from Rv0025 by 1aa, L73P"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976158.1"
/db_xref="GI:121635935"
/db_xref="GeneID:4696316"
/translation="MSEQAGSSVAVIQERQALLARQHDAVAEADRELADVLASAHAAM
RESVRRLDAIAAELDRAVPDQDQLAVDTLMGAREFQTFLVAKQREIVAVVAAAHELDR
AKSAVLKRLRAQYTEPAR"
misc_feature 58898..59236
/locus_tag="BCG_0056"
/note="Domain of unknown function (DUF4226); Region:
DUF4226; pfam10774"
/db_xref="CDD:119294"
gene 59369..60802
/locus_tag="BCG_0057"
/db_xref="GeneID:4695476"
CDS 59369..60802
/locus_tag="BCG_0057"
/note="In Mycobacterium bovis and Mycobacterium bovis BCG
Pasteur, a 4 bp insertion (*-atcg) leads to a longer
protein with a different COOH part compared to its homolog
in Mycobacterium tuberculosis strain H37Rv (477 aa versus
448 aa). Differs from Rv0026 by 1aa, P93Q"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976159.1"
/db_xref="GI:121635936"
/db_xref="GeneID:4695476"
/translation="MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVT
STTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHPNSATAQLDL
QVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIR
EVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPEL
PTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGAT
PALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDR
EGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQG
IAIPLPGTAVANPVDPARISAGDVGVFTDRHALALGPSKALLDGQIQHISAVRGRNFL
GWIHPAATATAPARTEAPTPTRPAAAR"
misc_feature 59588..59920
/locus_tag="BCG_0057"
/note="Domain of unknown function (DUF4226); Region:
DUF4226; pfam10774"
/db_xref="CDD:119294"
gene 60840..61157
/locus_tag="BCG_0058"
/db_xref="GeneID:4698607"
CDS 60840..61157
/locus_tag="BCG_0058"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976160.1"
/db_xref="GI:121635937"
/db_xref="GeneID:4698607"
/translation="MTDRIHVQPAHLRQAAAHHQQTADYLRTVPSSHDAIRESLDSLG
PIFSELRDTGRELLELRKQCYQQQADNHADIAQNLRTSAAMWEQHERAASRSLGNIID
GSR"
misc_feature 60840..61136
/locus_tag="BCG_0058"
/note="Protein of unknown function (DUF2580); Region:
DUF2580; pfam10824"
/db_xref="CDD:220883"
gene 61165..61470
/locus_tag="BCG_0059"
/db_xref="GeneID:4695862"
CDS 61165..61470
/locus_tag="BCG_0059"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976161.1"
/db_xref="GI:121635938"
/db_xref="GeneID:4695862"
/translation="MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETL
AEAILLTADVSCLKALLEVRNEIVAAGHTPSAQVPTTDDLNVAIEKLLAHQLRRRNR"
misc_feature 61165..61467
/locus_tag="BCG_0059"
/note="Protein of unknown function (DUF2694); Region:
DUF2694; pfam10904"
/db_xref="CDD:151351"
gene 61708..62805
/locus_tag="BCG_0060"
/db_xref="GeneID:4696897"
CDS 61708..62805
/locus_tag="BCG_0060"
/note="Differs from Rv0029 by 1aa, N190H"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976162.1"
/db_xref="GI:121635939"
/db_xref="GeneID:4696897"
/translation="MAIFGRWSARQRLRRATRESLTIPTFSSSLDCTTRVIGGLWPAE
LSSNTAETATLAEHLKADLHRIVGSANDELMVIWRAGMADSTRRAEEDRVIDRARASA
MRRVESAMRELRQITGRVPVEIPRMRGAGGSDLDTTRLMPAVTVVQPADQACTDWPVA
AAEDDEARLQRLLAFVARQEPRLNWAVGVNADGTTVLVTDVAHGWIPPGIALPEGVRL
LAPARRAGRAPELVGITTCCKTYTPGDSLRRAVDSTAPTSSVQPRALPAIAGLSVELG
IATQRHDGLPKIVHAMATAAGNGAAAEEVDLLRVHVDTALHHVLAQYPRVDPALLLNC
MLLAATERSVTGDPIAANYHFAWFRELDSRR"
gene 62875..63204
/locus_tag="BCG_0061"
/db_xref="GeneID:4695377"
CDS 62875..63204
/locus_tag="BCG_0061"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976163.1"
/db_xref="GI:121635940"
/db_xref="GeneID:4695377"
/translation="MVSGSDSRSEPSQLSDRDLVESVLRDLSEAADKWEALVTQAETV
TYSVDLGDVRAVANSDGRLLELTLHPGVMTGYAHGELADRVNLAITALRDEVEAENRA
RYGGRLQ"
misc_feature 62875..63201
/locus_tag="BCG_0061"
/note="Protein of unknown function (DUF2710); Region:
DUF2710; pfam10921"
/db_xref="CDD:151368"
gene 63233..63445
/locus_tag="BCG_0062"
/db_xref="GeneID:4696701"
CDS 63233..63445
/locus_tag="BCG_0062"
/codon_start=1
/transl_table=11
/product="remnant of a transposase"
/protein_id="YP_976164.1"
/db_xref="GI:121635941"
/db_xref="GeneID:4696701"
/translation="MLARHFGAGRKAHSRAVATLKADIQAWHPAGIQTPKPRCESDVF
ARIGHTSHPSTRKSRVGPGASEAPLA"
gene 63946..66261
/gene="bioF2"
/locus_tag="BCG_0063"
/db_xref="GeneID:4696691"
CDS 63946..66261
/gene="bioF2"
/locus_tag="BCG_0063"
/EC_number="2.3.1.47"
/codon_start=1
/transl_table=11
/product="8-amino-7-oxononanoate synthase bioF2"
/protein_id="YP_976165.1"
/db_xref="GI:121635942"
/db_xref="GeneID:4696691"
/translation="MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSV
CFDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPV
LAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVE
EALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQRE
DLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYR
KANLYRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHT
ATLARMMMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKL
GGVYGFYPRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDAL
NHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLAT
IAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFI
AGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATG
LARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTS
YLADHRQSDLDRALHVFAGLAEDLTPQGAAL"
misc_feature 64489..64866
/gene="bioF2"
/locus_tag="BCG_0063"
/note="Acetyltransferase (GNAT) domain; Region:
Acetyltransf_6; pfam13480"
/db_xref="CDD:205658"
misc_feature 65095..66225
/gene="bioF2"
/locus_tag="BCG_0063"
/note="7-keto-8-aminopelargonate synthetase and related
enzymes [Coenzyme metabolism]; Region: BioF; COG0156"
/db_xref="CDD:30505"
misc_feature 65215..66228
/gene="bioF2"
/locus_tag="BCG_0063"
/note="8-amino-7-oxononanoate synthase; Reviewed; Region:
PRK05958"
/db_xref="CDD:180327"
misc_feature order(65398..65403,65410..65412,65599..65601,65686..65688,
65695..65697,65779..65781,65788..65790)
/gene="bioF2"
/locus_tag="BCG_0063"
/note="pyridoxal 5'-phosphate binding pocket [chemical
binding]; other site"
/db_xref="CDD:99742"
misc_feature 65788..65790
/gene="bioF2"
/locus_tag="BCG_0063"
/note="catalytic residue [active]"
/db_xref="CDD:99742"
gene 66258..66521
/gene="acpA"
/locus_tag="BCG_0064"
/db_xref="GeneID:4695544"
CDS 66258..66521
/gene="acpA"
/locus_tag="BCG_0064"
/standard_name="acpP"
/codon_start=1
/transl_table=11
/product="acyl carrier protein"
/protein_id="YP_976166.1"
/db_xref="GI:121635943"
/db_xref="GeneID:4695544"
/translation="MKEAINATIQRILRTDRGITANQVLVDDLGFDSLKLFQLITELE
DEFDIAISFRDAQNIKTVGDVYTSVAVWFPETAKPAPLGKGTA"
misc_feature 66258..66464
/gene="acpA"
/locus_tag="BCG_0064"
/note="Acyl carrier protein [Lipid metabolism / Secondary
metabolites biosynthesis, transport, and catabolism];
Region: AcpP; COG0236"
/db_xref="CDD:223314"
gene 66518..66913
/locus_tag="BCG_0065"
/db_xref="GeneID:4695773"
CDS 66518..66913
/locus_tag="BCG_0065"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976167.1"
/db_xref="GI:121635944"
/db_xref="GeneID:4695773"
/translation="MTDDADLDLVRRTFAAFARGDLAELTQCFAPDVEQFVPGKHALA
GVFRGVDNVVACLGDTAAAADGTMTVTLEDVLSNTDGQVIAVYRLRASRAGKVLDQRE
AILVTVAGGRITRLSEFYADPAATESFWA"
misc_feature 66518..66910
/locus_tag="BCG_0065"
/note="Ketosteroid isomerase-related protein [General
function prediction only]; Region: COG3631"
/db_xref="CDD:226158"
gene 66910..68598
/gene="fadD34"
/locus_tag="BCG_0066"
/db_xref="GeneID:4697408"
CDS 66910..68598
/gene="fadD34"
/locus_tag="BCG_0066"
/EC_number="6.2.1.-"
/codon_start=1
/transl_table=11
/product="fatty-acid-CoA ligase"
/protein_id="YP_976168.1"
/db_xref="GI:121635945"
/db_xref="GeneID:4697408"
/translation="MTAALLSPAIAWQQISACTDRTLTITCEDSEVISYQDLIARAAA
CIPPLRRLDLKRGEPVLITAHTNLEFLSCFLGLMLHGAVPVPIPPREALKTTERFMTR
LGPLLRHHRVLICTPAEHDEIRAAASTDCQISRFTALAEAGDEQFGRATAQQLADTAT
ADWPLCTLDDDAYVQYTSGSTAAPRGVVITYRNLLSNMRAMAVGSQFQHGDVMGSWLP
LHHDMGLVGSLFAALFNSVSAVFTTPHRFLYDPLGFLRLLTSSGATHTFMPNFALEWL
INAYHRRGADIEGIDLHKMRRLIIASEPVHAEGMRRFAATFAGVGLAPTALGSGYGLA
EATVAVSMSAPNTGFRTETHAAAEVVTGGRVLPGYEVRIDAAPGARAGTIKLRGDSVA
AKAYVGGKKLDALDEEGFCDTHDLGFLVDDEIVILGRQDEVFIVHGENRFPYDIEFII
RGESEQHRTKVACFGVNERVVVVLESPLDSIIDKAEADRLRCQVVAATGLQLDELITV
RRGAIPTTTSGKLKRRAVAQAYRDGTLPRLATHAWTADPDSAPKTTRSSLEGAH"
misc_feature 66910..68526
/gene="fadD34"
/locus_tag="BCG_0066"
/note="Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases
II [Lipid metabolism / Secondary metabolites biosynthesis,
transport, and catabolism]; Region: CaiC; COG0318"
/db_xref="CDD:223395"
misc_feature 66946..68505
/gene="fadD34"
/locus_tag="BCG_0066"
/note="Fatty acyl-AMP ligase (FAAL); Region: FAAL;
cd05931"
/db_xref="CDD:213297"
misc_feature order(67429..67431,67438..67455,67459..67464)
/gene="fadD34"
/locus_tag="BCG_0066"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213297"
misc_feature order(67510..67512,67570..67578,67804..67806,67813..67824,
67897..67911,67924..67926,67993..67995,68152..68154,
68185..68187,68194..68196)
/gene="fadD34"
/locus_tag="BCG_0066"
/note="active site"
/db_xref="CDD:213297"
gene complement(68799..69479)
/locus_tag="BCG_0067c"
/db_xref="GeneID:4699133"
CDS complement(68799..69479)
/locus_tag="BCG_0067c"
/note="Differs from Mb0037c and Rv0036c by 1aa, L186P, and
at C-terminal end due to frameshift resulting from 1 bp
deletion at position equivalent to Mycobacterium
tuberculosis H37Rv2, 39228-39228, after codon 202"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976169.1"
/db_xref="GI:121635946"
/db_xref="GeneID:4699133"
/translation="MADPGPFVADLRAESDDLDALVAHLPADRWADPTPAPGWTIAHQ
IGHLLWTDRVALTAVTDEAGFAELMTAAAANPAGFVDDAATELAAVSPAELLTDWRVT
RGRLHEELLAVPDGRKLAWFGPPMSAASMATARLMETWAHGLDVADALGVIRPATQRL
RSIAHLGVRTRDYAFIVNNLTPPAELFLVELRGPSGDTWSWGHPMRPSGSPGPPRTSA
SWSPSGAR"
misc_feature complement(69039..69449)
/locus_tag="BCG_0067c"
/note="Mycothiol maleylpyruvate isomerase N-terminal
domain; Region: MDMPI_N; pfam11716"
/db_xref="CDD:204720"
gene complement(69527..70852)
/locus_tag="BCG_0068c"
/db_xref="GeneID:4697953"
CDS complement(69527..70852)
/locus_tag="BCG_0068c"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976170.1"
/db_xref="GI:121635947"
/db_xref="GeneID:4697953"
/translation="MPRVEVGLVIHSRMHARAPVDVWRSVRSLPDFWRLLQVRVASQF
GDGLFQAGLAGALLFNPDRAADPMAIAGAFAVLFLPYSLLGPFAGALMDRWDRRWVLV
GANTGRLALIAGVGTILAVGAGDVPLLVGALVANGLARFVASGLSAALPHVVPREQVV
TMNSVAIASGAVSAFLGANFMLLPRWLLGSGDEGASAIVFLVAIPVSIALLWSLRFGP
RVLGPDDTERAIHGSAVYAVVTGWLHGARTVVQLPTVAAGLSGLAAHRMVVGINSLLI
LLLVRHVTARAVGGLGTALLFFAATGLGAFLANVLTPTAIRRWGRYATANGALAAAAT
IQVAAAGLLVPVMVVCGFLLGVAGQVVKLCADSAMQMDVDDALRGHVFAVQDALFWVS
YILSITVAAALIPEHGHAPVFVLFGSAIYLAGLVVHTIVGRRGQPVIGR"
misc_feature complement(<70208..70669)
/locus_tag="BCG_0068c"
/note="H+ Antiporter protein; Region: 2A0121; TIGR00900"
/db_xref="CDD:162098"
gene 70954..71562
/locus_tag="BCG_0069"
/db_xref="GeneID:4696034"
CDS 70954..71562
/locus_tag="BCG_0069"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976171.1"
/db_xref="GI:121635948"
/db_xref="GeneID:4696034"
/translation="MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIV
EHNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRVGA
DPEGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWI
VLSALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN"
misc_feature 70990..71550
/locus_tag="BCG_0069"
/note="hypothetical protein; Validated; Region: PRK00228"
/db_xref="CDD:234694"
gene complement(71654..72001)
/locus_tag="BCG_0070c"
/db_xref="GeneID:4699368"
CDS complement(71654..72001)
/locus_tag="BCG_0070c"
/note="Differs from Rv0039c by 1aa, F24C"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976172.1"
/db_xref="GI:121635949"
/db_xref="GeneID:4699368"
/translation="MFLAGVLCMCAAAASALFGSWSLFHTPTADPTALALRAMAPTQL
AAAVMLAAGGVVAVAAPGHTALMVVIVCIAGAVGTLAAGSWQSAQYALRRETASPTAN
CVGSCAVCTQACH"
gene complement(72083..73015)
/gene="mtc28"
/locus_tag="BCG_0071c"
/db_xref="GeneID:4697254"
CDS complement(72083..73015)
/gene="mtc28"
/locus_tag="BCG_0071c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976173.1"
/db_xref="GI:121635950"
/db_xref="GeneID:4697254"
/translation="MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAP
VSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAI
SGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNS
VYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTY
RENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAP
AQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR"
misc_feature complement(72209..72709)
/gene="mtc28"
/locus_tag="BCG_0071c"
/note="Probable lipoprotein LpqN; Region: Lpp-LpqN;
pfam10738"
/db_xref="CDD:192662"
gene 73212..76121
/gene="leuS"
/locus_tag="BCG_0072"
/db_xref="GeneID:4697737"
CDS 73212..76121
/gene="leuS"
/locus_tag="BCG_0072"
/EC_number="6.1.1.4"
/note="leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA
synthetase; charges leucine by linking carboxyl group to
alpha-phosphate of ATP and then transfers
aminoacyl-adenylate to its tRNA; due to the large number
of codons that tRNA(Leu) recognizes, the leucyl-tRNA
synthetase does not recognize the anticodon loop of the
tRNA, but instead recognition is dependent on a conserved
discriminator base A37 and a long arm; an editing domain
hydrolyzes misformed products; in Methanothermobacter
thermautotrophicus this enzyme associates with prolyl-tRNA
synthetase"
/codon_start=1
/transl_table=11
/product="leucyl-tRNA synthetase"
/protein_id="YP_976174.1"
/db_xref="GI:121635951"
/db_xref="GeneID:4697737"
/translation="MTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWA
RLGTFNVPNPVGSLAPPDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARY
FRMVGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRR
SFSTTDVDFYRWTQWIFLQIYNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKL
TAGERADVIDEYRLVYRADSLVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQW
MMRITAYADRLLDDLDVLDWPEQVKTMQRNWIGRSTGAVALFSARAASDDGFEVDIEV
FTTRPDTLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRAIA
AKSDLERQESREKTGVFLGSYAINPANGEPVPIFIADYVLAGYGTGAIMAVPGHDQRD
WDFARAFGLPIVEVIAGGNISESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGR
GRARIEFKLRDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSPVLFD
PDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNS
ERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYSRFWHKVLYDLGHV
SSREPYRRLVNQGYIQAYAYTDARGSYVPAEQVIERGDRFVYPGPDGEVEVFQEFGKI
GKSLKNSVSPDEICDAYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVV
DEHTGETRVADGVELDIDTLRALHRTIVGVSEDFAALRNNTATAKLIEYTNHLTKKHR
DAVPRAAVEPLVQMLAPLAPHIAEELWLRLGNTTSLAHGPFPKADAAYLVDETVEYPV
QVNGKVRGRVVVAADTDEETLKAAVLTDEKVQAFLAGATPRKVIVVAGRLVNLVI"
misc_feature 73287..76118
/gene="leuS"
/locus_tag="BCG_0072"
/note="leucyl-tRNA synthetase; Validated; Region: leuS;
PRK00390"
/db_xref="CDD:234743"
misc_feature 73419..>74138
/gene="leuS"
/locus_tag="BCG_0072"
/note="nucleotidyl transferase superfamily; Region:
nt_trans; cl00015"
/db_xref="CDD:241550"
misc_feature 73467..73478
/gene="leuS"
/locus_tag="BCG_0072"
/note="active site"
/db_xref="CDD:173912"
misc_feature 73467..73478
/gene="leuS"
/locus_tag="BCG_0072"
/note="HIGH motif; other site"
/db_xref="CDD:173912"
misc_feature order(73467..73469,73476..73478)
/gene="leuS"
/locus_tag="BCG_0072"
/note="nucleotide binding site [chemical binding]; other
site"
/db_xref="CDD:173912"
misc_feature 74187..74723
/gene="leuS"
/locus_tag="BCG_0072"
/note="Leucyl-tRNA synthetase, Domain 2; Region:
tRNA-synt_1_2; pfam13603"
/db_xref="CDD:222257"
misc_feature <74760..>74888
/gene="leuS"
/locus_tag="BCG_0072"
/note="nucleotidyl transferase superfamily; Region:
nt_trans; cl00015"
/db_xref="CDD:241550"
misc_feature <75015..75545
/gene="leuS"
/locus_tag="BCG_0072"
/note="nucleotidyl transferase superfamily; Region:
nt_trans; cl00015"
/db_xref="CDD:241550"
misc_feature 75432..75443
/gene="leuS"
/locus_tag="BCG_0072"
/note="active site"
/db_xref="CDD:173912"
misc_feature 75432..75443
/gene="leuS"
/locus_tag="BCG_0072"
/note="KMSKS motif; other site"
/db_xref="CDD:173912"
misc_feature 75543..75869
/gene="leuS"
/locus_tag="BCG_0072"
/note="Anticodon-binding domain of bacterial and
eukaryotic mitochondrial leucyl tRNA synthetases; Region:
Anticodon_Ia_Leu_BEm; cd07958"
/db_xref="CDD:153412"
misc_feature order(75552..75554,75561..75566,75573..75575,75585..75587,
75723..75725,75735..75737,75744..75749,75756..75758,
75765..75767)
/gene="leuS"
/locus_tag="BCG_0072"
/note="tRNA binding surface [nucleotide binding]; other
site"
/db_xref="CDD:153412"
gene complement(76231..76857)
/locus_tag="BCG_0073c"
/db_xref="GeneID:4697485"
CDS complement(76231..76857)
/locus_tag="BCG_0073c"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein
(marR-family)"
/protein_id="YP_976175.1"
/db_xref="GI:121635952"
/db_xref="GeneID:4697485"
/translation="MSVVRSIGKKMQRISGPNALAVKGRPTQVYGHTHVRLDCRFMAD
SEFTAPEVTQLAEGLHRALSKLISMLRRGDPNGAAAGDLTLAQLSILVTLLDQGPIRM
TDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRAVLVDITPQGRAVHGESLANR
RAALAALLSQLPRSDLETLRKALAPLERLASGEPASGPASNSPARKRA"
misc_feature complement(<76399..76614)
/locus_tag="BCG_0073c"
/note="helix_turn_helix multiple antibiotic resistance
protein; Region: HTH_MARR; smart00347"
/db_xref="CDD:197670"
misc_feature complement(76435..76611)
/locus_tag="BCG_0073c"
/note="MarR family; Region: MarR; pfam01047"
/db_xref="CDD:201571"
gene complement(77016..77750)
/locus_tag="BCG_0074c"
/db_xref="GeneID:4695352"
CDS complement(77016..77750)
/locus_tag="BCG_0074c"
/codon_start=1
/transl_table=11
/product="GntR family transcriptional regulator"
/protein_id="YP_976176.1"
/db_xref="GI:121635953"
/db_xref="GeneID:4695352"
/translation="MPKKYGVKEKDQVVAHILNLLLTGKLRSGDRVDRNEIAHGLGVS
RVPIQEALVQLEHDGIVSTRYHRGAFIERFDVATILEHHELDGLLNGIASARAAANPT
PRILGQLDAVMRSLRNSKESRAFAECVWEYRRTVNDEYAGPRLHATIRASQNLIPRVF
WMTYQNSRDDVLPFYEEENAAIHRREPEAARAACIGRSELMAQTMLAELFRRRVLVPP
EGACPGPFGAPIPGFARSYQPSSPVP"
misc_feature complement(77115..77720)
/locus_tag="BCG_0074c"
/note="Transcriptional regulators [Transcription]; Region:
FadR; COG2186"
/db_xref="CDD:225097"
misc_feature complement(77538..77720)
/locus_tag="BCG_0074c"
/note="Winged helix-turn-helix (WHTH) DNA-binding domain
of the GntR family of transcriptional regulators; Region:
WHTH_GntR; cd07377"
/db_xref="CDD:153418"
misc_feature complement(order(77544..77555,77559..77564,77592..77594,
77601..77606,77610..77624,77646..77648,77652..77654))
/locus_tag="BCG_0074c"
/note="DNA-binding site [nucleotide binding]; DNA binding
site"
/db_xref="CDD:153418"
gene complement(77883..78677)
/locus_tag="BCG_0075c"
/db_xref="GeneID:4697694"
CDS complement(77883..78677)
/locus_tag="BCG_0075c"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976177.1"
/db_xref="GI:121635954"
/db_xref="GeneID:4697694"
/translation="MTSLVRPDLPVRIGVQLQPQHAPHYRAVRDAVRRCEDIGVDIAF
TWDHFFPLYGDPDGPHFECWTVLGAWAEQTSHIEIGALVTCNSYRNPELLADMARTVD
HISGGRLILGIGSGWKQKDYDEYGYRFGTAGSRLDDLAAALPRIKARLGKLNPPPTRD
IPVLIGGGGERKTLRLVAEYADIWHSFTAGDSYLAKSAVLSTHCSTVGRNPATIERSA
AVDGGGLIASAEALAGLGVTLLTVGCDGPDYDLSAAAALCRWRDGR"
misc_feature complement(77892..78647)
/locus_tag="BCG_0075c"
/note="probable F420-dependent oxidoreductase, MSMEG_2906
family; Region: F420_MSMEG_2906; TIGR03856"
/db_xref="CDD:213873"
misc_feature complement(<78081..>78305)
/locus_tag="BCG_0075c"
/note="Flavin-utilizing monoxygenases; Region:
Flavin_utilizing_monoxygenases; cl07892"
/db_xref="CDD:244823"
gene complement(78693..79589)
/locus_tag="BCG_0076c"
/db_xref="GeneID:4697521"
CDS complement(78693..79589)
/locus_tag="BCG_0076c"
/EC_number="3.-.-.-"
/codon_start=1
/transl_table=11
/product="hydrolase"
/protein_id="YP_976178.1"
/db_xref="GI:121635955"
/db_xref="GeneID:4697521"
/translation="MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALR
WGGSAPRVIFLHGGGQNAHTWDTVIVGLGEPALAVDLPGHGHSAWREDGNYSPQLNSE
TLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDVTPSALQRHAELTA
EQRGTVALMHGEREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRYD
AIRTFGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRATHFRGVHIVEKSG
HSVQSDQPRALIEIVRGVLDTR"
misc_feature complement(78696..79475)
/locus_tag="BCG_0076c"
/note="Predicted hydrolases or acyltransferases
(alpha/beta hydrolase superfamily) [General function
prediction only]; Region: MhpC; COG0596"
/db_xref="CDD:223669"
gene complement(79671..80774)
/gene="ino1"
/locus_tag="BCG_0077c"
/db_xref="GeneID:4696669"
CDS complement(79671..80774)
/gene="ino1"
/locus_tag="BCG_0077c"
/EC_number="5.5.1.4"
/standard_name="tbINO"
/note="Differs from Mb0047c by 1aa, T120I, and from
Rv0046c by 2aa, T120I, G190R"
/codon_start=1
/transl_table=11
/product="myo-inositol-1-phosphate synthase INO1"
/protein_id="YP_976179.1"
/db_xref="GI:121635956"
/db_xref="GeneID:4696669"
/translation="MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTS
TVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVI
VQRGPTLDGIGKYYADTTELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQC
AIDAGVAFVNALPVFIASDPVWAKKFTDAGVPIVGDDIKSQVGATITHRVLAKLFEDR
GVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDH
VGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIG
GPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG"
misc_feature complement(79680..80729)
/gene="ino1"
/locus_tag="BCG_0077c"
/note="Myo-inositol-1-phosphate synthase; Region:
NAD_binding_5; cl00554"
/db_xref="CDD:199325"
gene complement(80835..81377)
/locus_tag="BCG_0078c"
/db_xref="GeneID:4697433"
CDS complement(80835..81377)
/locus_tag="BCG_0078c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976180.1"
/db_xref="GI:121635957"
/db_xref="GeneID:4697433"
/translation="MLELAILGLLIESPMHGYELRKRLTGLLGAFRAFSYGSLYPALR
RMQADGLIAENAAPAGTPVRRARRVYQLTDKGRRRFGELVADTGPHNYTDDGFGVHLA
FFNRTPAEARMRILEGRRRQVEERREGLREAVARASSSFDRYTRQLHQLGLESSEREV
KWLNELIAAERAAPNPAEQT"
misc_feature complement(81042..81377)
/locus_tag="BCG_0078c"
/note="Predicted transcriptional regulators
[Transcription]; Region: COG1695"
/db_xref="CDD:224609"
misc_feature complement(81132..81362)
/locus_tag="BCG_0078c"
/note="Transcriptional regulator PadR-like family; Region:
PadR; pfam03551"
/db_xref="CDD:217610"
gene complement(81478..82347)
/locus_tag="BCG_0079c"
/db_xref="GeneID:4698581"
CDS complement(81478..82347)
/locus_tag="BCG_0079c"
/note="Differs from Rv0048c by 1aa, A250V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976181.1"
/db_xref="GI:121635958"
/db_xref="GeneID:4698581"
/translation="MAKWLGAPLARGVSTATRAKDSDRQDACRILDDALRDGELSMEE
HRERVSAATKAVTLGDLQRLVADLQVESAPAQMPALKSRAKRTELGLLAAAFVASVLL
GVGIGWGVYGNTRSPLDFTSDPGAKPDGIAPVVLTPPRQLHSLGGLTGLLEQTRKRFG
DTMGYRLVIYPEYASLDRVDPADDRRVLAYTYRGGWGDATSSAKSIADVSVVDLSKFD
AKTAVSIMRGAPETLGLKQSDVKSMYLIVEPAKDPTTPAALSLSLYVSSDYGGGYLVF
AGDGTIKHVSYPS"
misc_feature complement(82141..82299)
/locus_tag="BCG_0079c"
/note="Domain of unknown function (DUF1707); Region:
DUF1707; pfam08044"
/db_xref="CDD:149239"
gene 82481..82894
/locus_tag="BCG_0080"
/db_xref="GeneID:4696521"
CDS 82481..82894
/locus_tag="BCG_0080"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976182.1"
/db_xref="GI:121635959"
/db_xref="GeneID:4696521"
/translation="MDYTLRRRSLLAEVYSGRTGVSEVCDANPYLLRAAKFHGKPSRV
ICPICRKEQLTLVSWVFGEHLGAVSGSARTAEELILLATRFSEFAVHVVEVCRTCSWN
HLVKSYVLGAARPARPPRGSGGTRTARNGARTASE"
gene 83313..85358
/gene="ponA1"
/locus_tag="BCG_0081"
/db_xref="GeneID:4696779"
CDS 83313..85358
/gene="ponA1"
/locus_tag="BCG_0081"
/EC_number="2.4.2.-"
/EC_number="3.4.-.-"
/note="In Mycobacterium bovis BCG Pasteur, insertion of 3
codons after position 632 leads to a slightly longer
product compared to its homologs in Mycobacterium
tuberculosis strain H37Rv (681 aa versus 678 aa) and
Mycobacterium bovis AF2122/97 (681 aa versus 680 aa). In
addition, differs from Rv0050 by 1aa, L6P"
/codon_start=1
/transl_table=11
/product="bifunctional penicillin-binding protein 1A/1B
PONA1"
/protein_id="YP_976183.1"
/db_xref="GI:121635960"
/db_xref="GeneID:4696779"
/translation="MVILLLMVTFTMAYLIVDVPKPGDIRTNQVSTILASDGSEIAKI
VPPEGNRVDVNLSQVPMHVRQAVIAAEDRNFYSNPGFSFTGFARAVKNNLFGGDLQGG
STITQQYVKNALVGSAQHGWSGLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRG
AYGISAASKAYFDKPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMV
ETKALSPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQTLNT
QGLVVTTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVRAYYGGDNANGF
DFAQAGLQTGSSFKVFALVAALEQGIGLGYQVDSSPLTVDGIKITNVEGEGCGTCNIA
EALKMSLNTSYYRLMLKLNGGPQAVADAAHQAGIASSFPGVAHTLSEDGKGGPPNNGI
VLGQYQTRVIDMASAYATLAASGIYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPK
AVADNVTAAMEPIAGYSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTA
VWVGTVKGDEPLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAGV
PPPPPPPPPSEVPPSETVIQPTVEIAPGITIPIGPPTTITLAPPPPAPPAATPTPPP"
misc_feature 83421..83966
/gene="ponA1"
/locus_tag="BCG_0081"
/note="Transglycosylase; Region: Transgly; pfam00912"
/db_xref="CDD:201501"
misc_feature 83460..85130
/gene="ponA1"
/locus_tag="BCG_0081"
/note="penicillin-binding protein, 1A family; Region:
PBP_1a_fam; TIGR02074"
/db_xref="CDD:211713"
misc_feature 84240..85115
/gene="ponA1"
/locus_tag="BCG_0081"
/note="Penicillin binding protein transpeptidase domain;
Region: Transpeptidase; pfam00905"
/db_xref="CDD:144486"
gene 85355..87037
/locus_tag="BCG_0082"
/db_xref="GeneID:4696279"
CDS 85355..87037
/locus_tag="BCG_0082"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976184.1"
/db_xref="GI:121635961"
/db_xref="GeneID:4696279"
/translation="MTGALSQSSNISPLPLAADLRSADNRDCPSRTDVLGAALANVVG
GPVGRHALIGRTRLMTPLRVMFAIALVFLALGWSTKAACLQSTGTGPGDQRVANWDNQ
RAYYQLCYSDTVPLYGAELLSQGKFPYKSSWIETDSNGTPQLRYDGQIAVRYMEYPVL
TGIYQYLSMAIAKTYTALSKVAPLPVVAEVVMFFNVAAFGLALAWLTTVWATSGLAGR
RIWDAALVAASPLVIFQIFTNFDALATGLATSGLLAWARRRPVLAGVLIGLGSAAKLY
PLLFLYPLLLLGIRAGRLNALARTMAAAAATWLLVNLPVMLLFPRGWSEFFRLNTRRG
DDMDSLYNVVKSFTGWRGFDPTLGFWEPPLVLNTVVTLLFVLCCAAIAYIALTAPHRP
RVAQLTFLTVASFLLVNKVWSPQFSLWLVPLAVLALPHRRILLAWMTIDALVWVPRMY
YLYGNPSRSLPEQWFTTTVLLRDIAVMVLCGLVVWQIYRPGRDLVRTGGPGALPACGG
VDDPVGGVFANAADAPPGRLPSWLRPRLGDEHARERTPDAGRDRTFSGQHRA"
misc_feature 85412..87034
/locus_tag="BCG_0082"
/note="Predicted integral membrane protein [Function
unknown]; Region: COG5650"
/db_xref="CDD:227937"
gene 87069..87632
/locus_tag="BCG_0083"
/db_xref="GeneID:4697704"
CDS 87069..87632
/locus_tag="BCG_0083"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976185.1"
/db_xref="GI:121635962"
/db_xref="GeneID:4697704"
/translation="MPSFDVVFVGHRRGEVRSDNAMLGLLCDAAFDELTRPDVVIFPG
GIGTRTLIHDQTVLDWVREAHRHTLLTTSVCTGGLVLAAAGLLNGLTATTHWRVQDLF
NSLGARYVPQRVVEHLPERVITAAGVSSGIDMGLRLVELLVSREAAEASQLMIEYDPQ
PPVDAGSLAKASPATHRLALEFYQHRL"
misc_feature 87072..87542
/locus_tag="BCG_0083"
/note="Type 1 glutamine amidotransferase (GATase1)-like
domain found in a subgroup of proteins similar to PfpI
from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139"
/db_xref="CDD:153233"
misc_feature 87291..87293
/locus_tag="BCG_0083"
/note="conserved cys residue [active]"
/db_xref="CDD:153233"
gene 87851..88141
/gene="rpsF"
/locus_tag="BCG_0084"
/db_xref="GeneID:4695848"
CDS 87851..88141
/gene="rpsF"
/locus_tag="BCG_0084"
/note="binds cooperatively with S18 to the S15-16S
complex, allowing platform assembly to continue with S11
and S21"
/codon_start=1
/transl_table=11
/product="30S ribosomal protein S6"
/protein_id="YP_976186.1"
/db_xref="GI:121635963"
/db_xref="GeneID:4695848"
/translation="MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWG
KRRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH"
misc_feature 87851..88138
/gene="rpsF"
/locus_tag="BCG_0084"
/note="30S ribosomal protein S6; Reviewed; Region: rpsF;
PRK00453"
/db_xref="CDD:179034"
gene 88245..88739
/gene="ssb"
/locus_tag="BCG_0085"
/db_xref="GeneID:4697300"
CDS 88245..88739
/gene="ssb"
/locus_tag="BCG_0085"
/note="binds to single stranded DNA and may facilitate the
binding and interaction of other proteins to DNA"
/codon_start=1
/transl_table=11
/product="single-stranded DNA-binding protein"
/protein_id="YP_976187.1"
/db_xref="GI:121635964"
/db_xref="GeneID:4697300"
/translation="MAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQT
GEWKDGEALFLRCNIWREAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVE
VDEIGPSLRYATAKVNKASRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDD
EPPF"
misc_feature 88248..88736
/gene="ssb"
/locus_tag="BCG_0085"
/note="Single-stranded DNA-binding protein [DNA
replication, recombination, and repair]; Region: Ssb;
COG0629"
/db_xref="CDD:223702"
misc_feature 88263..88568
/gene="ssb"
/locus_tag="BCG_0085"
/note="SSB_OBF: A subfamily of OB folds similar to the OB
fold of ssDNA-binding protein (SSB). SSBs bind with high
affinity to ssDNA. They bind to and protect ssDNA
intermediates during DNA metabolic pathways. All bacterial
and eukaryotic SSBs studied to date...; Region: SSB_OBF;
cd04496"
/db_xref="CDD:239942"
misc_feature order(88263..88274,88347..88355,88401..88403,88407..88409,
88470..88472,88497..88499,88530..88532,88539..88541)
/gene="ssb"
/locus_tag="BCG_0085"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:239942"
misc_feature order(88278..88286,88302..88304,88332..88334,88353..88358,
88395..88400,88404..88406,88410..88412,88416..88418,
88422..88424,88461..88466,88488..88490,88494..88496,
88500..88505,88542..88544,88548..88550)
/gene="ssb"
/locus_tag="BCG_0085"
/note="ssDNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:239942"
misc_feature order(88470..88472,88476..88478,88482..88484,88563..88565)
/gene="ssb"
/locus_tag="BCG_0085"
/note="tetramer (dimer of dimers) interface [polypeptide
binding]; other site"
/db_xref="CDD:239942"
gene 88781..89035
/gene="rpsR"
/locus_tag="BCG_0086"
/db_xref="GeneID:4695625"
CDS 88781..89035
/gene="rpsR"
/locus_tag="BCG_0086"
/note="binds as a heterodimer with protein S6 to the
central domain of the 16S rRNA; helps stabilize the
platform of the 30S subunit"
/codon_start=1
/transl_table=11
/product="30S ribosomal protein S18"
/protein_id="YP_976188.1"
/db_xref="GI:121635965"
/db_xref="GeneID:4695625"
/translation="MAKSSKRRPAPEKPVKTRKCVFCAKKDQAIDYKDTALLRTYISE
RGKIRARRVTGNCVQHQRDIALAVKNAREVALLPFTSSVR"
misc_feature 88793..89026
/gene="rpsR"
/locus_tag="BCG_0086"
/note="30S ribosomal protein S18; Reviewed; Region: rpsR;
PRK00391"
/db_xref="CDD:178997"
gene 89068..89526
/gene="rplI"
/locus_tag="BCG_0087"
/db_xref="GeneID:4695807"
CDS 89068..89526
/gene="rplI"
/locus_tag="BCG_0087"
/note="in Escherichia coli this protein is wrapped around
the base of the L1 stalk"
/codon_start=1
/transl_table=11
/product="50S ribosomal protein L9"
/protein_id="YP_976189.1"
/db_xref="GI:121635966"
/db_xref="GeneID:4695807"
/translation="MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQ
KQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVA
AIKKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS"
misc_feature 89068..89520
/gene="rplI"
/locus_tag="BCG_0087"
/note="50S ribosomal protein L9; Reviewed; Region: rplI;
PRK00137"
/db_xref="CDD:234659"
misc_feature 89068..89205
/gene="rplI"
/locus_tag="BCG_0087"
/note="Ribosomal protein L9, N-terminal domain; Region:
Ribosomal_L9_N; pfam01281"
/db_xref="CDD:201708"
misc_feature 89251..89520
/gene="rplI"
/locus_tag="BCG_0087"
/note="Ribosomal protein L9, C-terminal domain; Region:
Ribosomal_L9_C; pfam03948"
/db_xref="CDD:146531"
gene 89555..90076
/locus_tag="BCG_0088"
/db_xref="GeneID:4695924"
CDS 89555..90076
/locus_tag="BCG_0088"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976190.1"
/db_xref="GI:121635967"
/db_xref="GeneID:4695924"
/translation="MPVVTAVGRRRGFAMPWVSTARSGAVMLANYSAGVCGRVSSPGL
NVRKMCLKANTPGAVTWLDTPKRFLSTQTASRCMAVNSSDVVTGRIDPQVLHTPLNTD
VDGYAHAMHSSINSGPLEYLPATFSVFPALGDVGDLGGGVGAATYALDRLSNMRSGAC
VGGGESPWRSLMT"
gene 90055..92679
/gene="dnaB"
/locus_tag="BCG_0089"
/db_xref="GeneID:4696243"
CDS 90055..92679
/gene="dnaB"
/locus_tag="BCG_0089"
/EC_number="3.6.1.-"
/note="unwinds double stranded DNA; these Mycobacterial
enzymes appear to contain inteins"
/codon_start=1
/transl_table=11
/product="replicative DNA helicase"
/protein_id="YP_976191.1"
/db_xref="GI:121635968"
/db_xref="GeneID:4696243"
/translation="MAVVDDLAPGMDSSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDA
IADVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRRIGGAPY
LHTLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQ
AEIYDVADRRLSEDFVALEDLLQPTMDEIDAIASSGGLARGVATGFTELDEVTNGLHP
GQMVIVAARPGVGKSTLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKL
SDMRSGRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKANLKLIV
VDYLQLMTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLNRGPEQRTDKKPML
ADLRESGCLTASTRILRADTGAEVAFGELMRSGERPMVWSLDERLRMVARPMINVFPS
GRKEVFRLRLASGREVEATGSHPFMKFEGWTPLAQLKVGDRIAAPRRVPEPIDTQRMP
ESELISLARMIGDGSCLKNQPIRYEPVDEANLAAVTVSAAHSDGAAIRDDYLAARVPS
LRPARQRLPRGRCTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAG
GSVRWDPTNGQGRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRLHIHG
AKDQVRFLRHVGVHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWAQVRNRLSAKQMM
DIQLHEPTMWKHSPSRSRPHRAEARIEDRAIHELARGDAYWDTVVEITSIGDQHVFDG
TVSGTHNFVANGISLHNSLEQDADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTK
TVTVAHQLHLSRFANMAR"
misc_feature 90055..92676
/gene="dnaB"
/locus_tag="BCG_0089"
/note="replicative DNA helicase; Validated; Region:
PRK07773"
/db_xref="CDD:236093"
misc_feature 90121..90429
/gene="dnaB"
/locus_tag="BCG_0089"
/note="DnaB-like helicase N terminal domain; Region: DnaB;
pfam00772"
/db_xref="CDD:216111"
misc_feature 90673..>91251
/gene="dnaB"
/locus_tag="BCG_0089"
/note="DnaB helicase C terminal domain. The hexameric
helicase DnaB unwinds the DNA duplex at the chromosome
replication fork. Although the mechanism by which DnaB
both couples ATP hydrolysis to translocation along DNA and
denatures the duplex is unknown, a...; Region: DnaB_C;
cd00984"
/db_xref="CDD:238484"
misc_feature 90733..90753
/gene="dnaB"
/locus_tag="BCG_0089"
/note="Walker A motif; other site"
/db_xref="CDD:238484"
misc_feature order(90748..90753,91060..91062,91183..91185)
/gene="dnaB"
/locus_tag="BCG_0089"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:238484"
misc_feature 91051..91062
/gene="dnaB"
/locus_tag="BCG_0089"
/note="Walker B motif; other site"
/db_xref="CDD:238484"
misc_feature order(91075..91080,91099..91107,91180..91206)
/gene="dnaB"
/locus_tag="BCG_0089"
/note="DNA binding loops [nucleotide binding]"
/db_xref="CDD:238484"
misc_feature 91252..>91548
/gene="dnaB"
/locus_tag="BCG_0089"
/note="Hedgehog/Intein domain, found in Hedgehog proteins
as well as proteins which contain inteins and undergo
protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In
protein splicing an intervening polypeptide sequence - the
intein - is excised from a protein; Region: Hint; cd00081"
/db_xref="CDD:238035"
misc_feature order(91252..91254,91459..91461,91468..91470)
/gene="dnaB"
/locus_tag="BCG_0089"
/note="thioester formation/cholesterol transfer; other
site"
/db_xref="CDD:238035"
misc_feature order(91252..91254,91468..91470)
/gene="dnaB"
/locus_tag="BCG_0089"
/note="protein-splicing catalytic site; other site"
/db_xref="CDD:238035"
misc_feature <92371..92499
/gene="dnaB"
/locus_tag="BCG_0089"
/note="Hedgehog/Intein domain, found in Hedgehog proteins
as well as proteins which contain inteins and undergo
protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In
protein splicing an intervening polypeptide sequence - the
intein - is excised from a protein; Region: Hint; cd00081"
/db_xref="CDD:238035"
misc_feature 92494..92499
/gene="dnaB"
/locus_tag="BCG_0089"
/note="protein-splicing catalytic site; other site"
/db_xref="CDD:238035"
misc_feature <92500..92646
/gene="dnaB"
/locus_tag="BCG_0089"
/note="RecA-like NTPases. This family includes the NTP
binding domain of F1 and V1 H+ATPases, DnaB and related
helicases as well as bacterial RecA and related eukaryotic
and archaeal recombinases. This group also includes
bacterial conjugation proteins and...; Region:
RecA-like_NTPases; cl17233"
/db_xref="CDD:247787"
gene 92859..93551
/locus_tag="BCG_0090"
/db_xref="GeneID:4697423"
CDS 92859..93551
/locus_tag="BCG_0090"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976192.1"
/db_xref="GI:121635969"
/db_xref="GeneID:4697423"
/translation="MITRYKPESGFVARSGGPDRKRPHDWIVWHFTHADNLPGIITAG
RLLADSAVTPTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSPMLYVVC
KGHSGYSGGAGPLVHLGVALGDIIDADLTWCASDGNAAASYTKFSRQVDTLGTFVDFD
LLCQRQWHNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYNTETMTRVRTLLDPVGG
VRKYVIKPGMYY"
gene 93568..94626
/locus_tag="BCG_0091"
/db_xref="GeneID:4697073"
CDS 93568..94626
/locus_tag="BCG_0091"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976193.1"
/db_xref="GI:121635970"
/db_xref="GeneID:4697073"
/translation="MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFT
AYEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRV
IRELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVE
GLRMTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFT
PGRYGPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAA
ADRVSAAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGR
IYSDDRIGVALDRILMTA"
misc_feature 93568..93984
/locus_tag="BCG_0091"
/note="Macro domain, Poa1p_like family. The macro domain
is a high-affinity ADP-ribose binding module found in a
variety of proteins as a stand-alone domain or in
combination with other domains like in histone macroH2A
and some PARPs (poly ADP-ribose...; Region:
Macro_Poa1p_like; cd02901"
/db_xref="CDD:239230"
misc_feature order(93589..93594,93631..93633,93652..93654,93658..93663,
93916..93918,93922..93930)
/locus_tag="BCG_0091"
/note="ADP-ribose binding site [chemical binding]; other
site"
/db_xref="CDD:239230"
misc_feature 93829..94500
/locus_tag="BCG_0091"
/note="Predicted phosphatase homologous to the C-terminal
domain of histone macroH2A1 [General function prediction
only]; Region: COG2110"
/db_xref="CDD:225021"
gene 94650..95075
/locus_tag="BCG_0092"
/db_xref="GeneID:4697355"
CDS 94650..95075
/locus_tag="BCG_0092"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976194.1"
/db_xref="GI:121635971"
/db_xref="GeneID:4697355"
/translation="MCADAQPSGSVGLLGRNCPTATTRWRRAGEGLTAADTIEVKLWA
GKPRLHPLVPKRAVGVLLAVAHGQVAKTPSATRAIAFRHVRLMRVRWICAGNRGRKHK
RRCTTQYRSTQASKLQLHFKLRQTLNRLGGLQAMVSACG"
gene 95211..96353
/gene="celA1"
/locus_tag="BCG_0093"
/db_xref="GeneID:4696098"
CDS 95211..96353
/gene="celA1"
/locus_tag="BCG_0093"
/EC_number="3.2.1.4"
/note="Differs from Mb0063 by 1aa, A72D, and from Rv0062
by 2aa, A72D, V106I"
/codon_start=1
/transl_table=11
/product="cellulase celA1 (endoglucanase)"
/protein_id="YP_976195.1"
/db_xref="GI:121635972"
/db_xref="GeneID:4696098"
/translation="MTRRTGQRWRGTLPGRRPWTRPAPATCRRHLAFVELRHYFARVM
SSAIGSVARWIVPLLGVAAVASIGVIAAPVRVVRAPALILVDAANPLAGKPFYVDPAS
AAMVAARNANPPNAELTSVANTPQSYWLDQAFPPATVGGTVARYTGAAQAAGAMPVLT
LYGIPHRDCGSYASGGFATGTDYRGWIDAVASGLGSSPATIIVEPDALAMADCLSPDQ
RQERFDLVRYAVDTLTRDPAAAVYVDAGHSRWLSAEAMAARLNDVGVGRARGFSLNVS
NFYTTDEEIGYGEAISGLTNGSHYVIDTSRNGAGPAPDAPLNWCNPSGRALGAPPTTA
TAGAHADAYLWIKRPGESDGTCGRGEPQAGRFVSQYAIDLAHNAGQ"
misc_feature 95562..96308
/gene="celA1"
/locus_tag="BCG_0093"
/note="Glycosyl hydrolases family 6; Region:
Glyco_hydro_6; pfam01341"
/db_xref="CDD:189947"
gene 96582..98021
/locus_tag="BCG_0094"
/db_xref="GeneID:4697596"
CDS 96582..98021
/locus_tag="BCG_0094"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976196.1"
/db_xref="GI:121635973"
/db_xref="GeneID:4697596"
/translation="MAREISRQTFLRGAAGALAAGAVFGSVRATADPAASGWEALSSA
LGGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAFAAANNLKVAP
RGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTVTPATGLYAMHQVLAAAGRG
IPTGTCPTVGVAGHALGGGLGANSRHAGLLCDQLTSASVVLPSGQAVTASATDHPDLF
WALRGGGGGNFGVTTSLTFATFPSGDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSW
ALADATVDPLGTHCRILATCPAGSGGSVAAAIVSAVGTQPTGTENHTFNYLDLVRYLA
VGNLNPSPLGYVGGSDVFTTITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVS
PGATAFPWRRQSALVQWYVETSGSPSEATSWLNTAHQAVRAYSVGGYVNYLEVNQPPA
RYFGPNLSRLSAVRQKYDPSRVMFSGLNF"
misc_feature 96699..98018
/locus_tag="BCG_0094"
/note="FAD/FMN-containing dehydrogenases [Energy
production and conversion]; Region: GlcD; COG0277"
/db_xref="CDD:223354"
misc_feature 96801..97211
/locus_tag="BCG_0094"
/note="FAD binding domain; Region: FAD_binding_4;
pfam01565"
/db_xref="CDD:216574"
misc_feature 97896..97997
/locus_tag="BCG_0094"
/note="Berberine and berberine like; Region: BBE;
pfam08031"
/db_xref="CDD:219706"
gene 98279..101218
/locus_tag="BCG_0095"
/db_xref="GeneID:4696895"
CDS 98279..101218
/locus_tag="BCG_0095"
/note="Differs from Mb0065 by 1aa, T435I, and from Rv0064
by 4aa, T435I, D457G, F550V, P906R"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976197.1"
/db_xref="GI:121635974"
/db_xref="GeneID:4696895"
/translation="METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWL
WFGEVGFRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDPVA
PLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIVDPEFGYDIGF
FVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAARVQLAVFAG
AVVLLKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFT
AIFLRDLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATRE
AYRIGGDWVQYRSYPGIGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFS
FAEILDIDRYRIDGELQDYIVGVRELSPKSLTGNQTDWINKHTVYTHGNGFVAAPANR
VNAAARDAENISDSNSGYPIYAVSDIASLGSGRQVIPVEQPRVYYGEVIAQADPDYAI
VGGAPGSAPREYDTDTSKYTYTGAGGVSIGNWFNRTVFATKFAQHKFLFSREIGSESK
VLIHRDPKERVQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPV
TSPTGIVRQGKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSED
QIPDELRAHFRYPEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNDANATQPP
FYVLVGDQQSAQPSFRLASAMVGYNREFLSAYISAHSDPANYGKLTVLELPTDTLTQG
PQQIQNSMISDTRVASERTLLERSNRIHYGNLLSLPIADGGVLYVEPLYTERISTSPS
SSTFPQLSRVLVSVREPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATAPGGDAASAP
PPGAGGPAPPQAVPPPRTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAID
AAETPGG"
misc_feature 98279..101215
/locus_tag="BCG_0095"
/note="hypothetical protein; Provisional; Region:
PRK12438"
/db_xref="CDD:171499"
misc_feature 98285..100978
/locus_tag="BCG_0095"
/note="hypothetical protein; Validated; Region: PRK00068"
/db_xref="CDD:178837"
gene 101285..101524
/locus_tag="BCG_0095A"
/db_xref="GeneID:4697388"
CDS 101285..101524
/locus_tag="BCG_0095A"
/note="Differs from Rv0064A by 1aa,V48A"
/codon_start=1
/transl_table=11
/product="antitoxin"
/protein_id="YP_976198.1"
/db_xref="GI:121635975"
/db_xref="GeneID:4697388"
/translation="MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRD
KAEVIEILEQALASTASPGISRETIEASRRELRGG"
gene 101517..101918
/locus_tag="BCG_0096"
/db_xref="GeneID:4697383"
CDS 101517..101918
/locus_tag="BCG_0096"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976199.1"
/db_xref="GI:121635976"
/db_xref="GeneID:4697383"
/translation="MDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEV
GHALRRAVLSDEISEEQARAALDALPYLIDNRYPHSPRLIEYTWQLRHNVTFYDALYV
ALATALDVPLLTGDSRLAAAPGLPCEIKLVR"
misc_feature <101622..101888
/locus_tag="BCG_0096"
/note="PIN domain of the Pyrobaculum aerophilum Pae0151
and Pae2754 proteins and homologs; Region: PIN_Pae0151;
cd09873"
/db_xref="CDD:189043"
misc_feature order(101625..101633,101637..101654,101658..101666,
101700..101705,101709..101714,101721..101723,
101766..101768,101772..101777,101781..101786,
101796..101810,101814..101816,101859..101870,
101880..101882)
/locus_tag="BCG_0096"
/note="homotetrameric interface [polypeptide binding];
other site"
/db_xref="CDD:189043"
misc_feature order(101643..101645,101808..101810,101862..101864)
/locus_tag="BCG_0096"
/note="putative active site [active]"
/db_xref="CDD:189043"
misc_feature 101862..101864
/locus_tag="BCG_0096"
/note="metal binding site [ion binding]; metal-binding
site"
/db_xref="CDD:189043"
gene complement(101970..104207)
/gene="icd2"
/locus_tag="BCG_0097c"
/db_xref="GeneID:4695423"
CDS complement(101970..104207)
/gene="icd2"
/locus_tag="BCG_0097c"
/EC_number="1.1.1.42"
/note="Differs from Rv0066c by 1aa, N117K"
/codon_start=1
/transl_table=11
/product="isocitrate dehydrogenase"
/protein_id="YP_976200.1"
/db_xref="GI:121635977"
/db_xref="GeneID:4695423"
/translation="MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDI
SVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKEL
QDKGYAVPDYPADPNTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKH
PHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPL
DDGDVIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIF
YKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMV
DSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEII
NFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLT
ENVEAGDIWRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTY
LKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSA
KMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKT
GNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQ
LAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAAL
EAVQG"
misc_feature complement(101973..104207)
/gene="icd2"
/locus_tag="BCG_0097c"
/note="Monomeric isocitrate dehydrogenase [Energy
production and conversion]; Region: Icd; COG2838"
/db_xref="CDD:225394"
misc_feature complement(101982..104189)
/gene="icd2"
/locus_tag="BCG_0097c"
/note="Monomeric isocitrate dehydrogenase; Region: IDH;
pfam03971"
/db_xref="CDD:112770"
gene complement(104325..104894)
/locus_tag="BCG_0098c"
/db_xref="GeneID:4699214"
CDS complement(104325..104894)
/locus_tag="BCG_0098c"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976201.1"
/db_xref="GI:121635978"
/db_xref="GeneID:4699214"
/translation="MAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAG
VGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGA
TDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLV
GCQAMQSYNAELAAKVTDVALDGLRANRK"
misc_feature complement(<104559..104837)
/locus_tag="BCG_0098c"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature complement(104703..104837)
/locus_tag="BCG_0098c"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 104997..105908
/locus_tag="BCG_0099"
/db_xref="GeneID:4697775"
CDS 104997..105908
/locus_tag="BCG_0099"
/EC_number="1.-.-.-"
/note="Differs from Rv0068 by 1aa, L214V"
/codon_start=1
/transl_table=11
/product="short chain dehydrogenase"
/protein_id="YP_976202.1"
/db_xref="GI:121635979"
/db_xref="GeneID:4697775"
/translation="MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLA
VRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAG
VMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIH
FDDLQWERRYRRVAAYGQAKLANLLFTYELQRRLAPGGTTIAVASHPGVSNTELVRNM
PRPLVAVAAILAPLMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASS
AQSHDEQLQRRLWAVSEELTGVVYPVG"
misc_feature 104997..105902
/locus_tag="BCG_0099"
/note="short chain dehydrogenase; Provisional; Region:
PRK06197"
/db_xref="CDD:235737"
misc_feature 105036..105863
/locus_tag="BCG_0099"
/note="retinol dehydrogenase (retinol-DH), Light dependent
Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and
related proteins, classical (c) SDRs; Region:
retinol-DH_like_SDR_c_like; cd05327"
/db_xref="CDD:212492"
misc_feature order(105057..105059,105063..105074,105129..105137,
105210..105218,105294..105302,105357..105359,
105456..105458,105459..105461,105522..105524,
105534..105536,105615..105626,105630..105635)
/locus_tag="BCG_0099"
/note="putative NAD(P) binding site [chemical binding];
other site"
/db_xref="CDD:212492"
misc_feature order(105360..105362,105459..105461,105522..105524,
105534..105536)
/locus_tag="BCG_0099"
/note="active site"
/db_xref="CDD:212492"
gene complement(105933..107318)
/gene="sdaA"
/locus_tag="BCG_0100c"
/db_xref="GeneID:4696487"
CDS complement(105933..107318)
/gene="sdaA"
/locus_tag="BCG_0100c"
/EC_number="4.3.1.17"
/codon_start=1
/transl_table=11
/product="l-serine dehydratase sdaA"
/protein_id="YP_976203.1"
/db_xref="GI:121635980"
/db_xref="GeneID:4696487"
/translation="MTISVFDLFTIGIGPSSSHTVGPMRAANQFVVALRRRGHLDDLE
AMRVDLFGSLAATGAGHGTMSAILLGLEGCQPETITTEHKERRLAEIAASGVTRIGGV
IPVPLTERDIDLHPDIVLPTHPNGMTFTAAGPHGRVLATETYFSVGGGFIVTEQTSGN
SGQHPCSVALPYVSAQELLDICDRLDVSISEAALRNETCCRTENEVRAALLHLRDVMV
ECEQRSIAREGLLPGGLRVRRRAKVWYDRLNAEDPTRKPEFAEDWVNLVALAVNEENA
SGGRVVTAPTNGAAGIVPAVLHYAIHYTSAGAGDPDDVTVRFLLTAGAIGSLFKERAS
ISGAEVGCQGEVGSAAAMAAAGLAEILGGTPRQVENAAEIAMEHSLGLTCDPIAGLVQ
IPCIERNAISAGKAINAARMALRGDGIHRVTLDQVIDTMRATGADMHTKYKETSAGGL
AINVAVNIVEC"
misc_feature complement(105957..107312)
/gene="sdaA"
/locus_tag="BCG_0100c"
/note="L-serine dehydratase, iron-sulfur-dependent, single
chain form; Region: sda_mono; TIGR00720"
/db_xref="CDD:188076"
misc_feature complement(106839..107309)
/gene="sdaA"
/locus_tag="BCG_0100c"
/note="Serine dehydratase beta chain; Region: SDH_beta;
pfam03315"
/db_xref="CDD:217489"
misc_feature complement(105960..106772)
/gene="sdaA"
/locus_tag="BCG_0100c"
/note="Serine dehydratase alpha chain; Region: SDH_alpha;
pfam03313"
/db_xref="CDD:217488"
gene complement(107315..108592)
/gene="glyA"
/locus_tag="BCG_0101c"
/db_xref="GeneID:4697898"
CDS complement(107315..108592)
/gene="glyA"
/locus_tag="BCG_0101c"
/EC_number="2.1.2.1"
/note="catalyzes the reaction of glycine with
5,10-methylenetetrahydrofolate to form L-serine and
tetrahydrofolate"
/codon_start=1
/transl_table=11
/product="serine hydroxymethyltransferase"
/protein_id="YP_976204.1"
/db_xref="GI:121635981"
/db_xref="GeneID:4697898"
/translation="MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVM
QAQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATAN
AATMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVA
EAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPV
PHAHVVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLGHVIAAKATAFK
MAAQPEFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDG
QQAEDRLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAA
ALTATNDDQLGPLRAQVQRLAARYPLYPELHRT"
misc_feature complement(107327..108586)
/gene="glyA"
/locus_tag="BCG_0101c"
/note="serine hydroxymethyltransferase; Reviewed; Region:
glyA; PRK00011"
/db_xref="CDD:234571"
misc_feature complement(107441..108559)
/gene="glyA"
/locus_tag="BCG_0101c"
/note="Serine-glycine hydroxymethyltransferase (SHMT).
This family belongs to pyridoxal phosphate (PLP)-dependent
aspartate aminotransferase superfamily (fold I). SHMT
carries out interconversion of serine and glycine; it
catalyzes the transfer of hydroxymethyl...; Region: SHMT;
cd00378"
/db_xref="CDD:99733"
misc_feature complement(order(107747..107749,107801..107803,
108176..108181,108284..108286,108305..108307,
108350..108352,108374..108379,108431..108433,
108485..108487,108500..108502,108527..108532,
108551..108553,108557..108559))
/gene="glyA"
/locus_tag="BCG_0101c"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:99733"
misc_feature complement(order(107492..107494,107885..107887,
107903..107908,107981..107983,107990..107992,
108065..108067,108215..108217,108296..108301,
108398..108400,108428..108430,108488..108490))
/gene="glyA"
/locus_tag="BCG_0101c"
/note="glycine-pyridoxal phosphate binding site [chemical
binding]; other site"
/db_xref="CDD:99733"
misc_feature complement(order(107492..107494,107903..107905,
108215..108217,108488..108490))
/gene="glyA"
/locus_tag="BCG_0101c"
/note="active site"
/db_xref="CDD:99733"
misc_feature complement(order(107540..107542,107825..107827,
108212..108214,108218..108220,108230..108232,
108401..108403,108422..108424))
/gene="glyA"
/locus_tag="BCG_0101c"
/note="folate binding site [chemical binding]; other site"
/db_xref="CDD:99733"
gene 109182..109934
/locus_tag="BCG_0102"
/db_xref="GeneID:4697847"
CDS 109182..109934
/locus_tag="BCG_0102"
/note="In Mycobacterium bovis BCG Pasteur, a 45 bp
insertion (5 copies of VDP repeat) leads to longer
products compared to its homologs in Mycobacterium
tuberculosis strain H37Rv (250 aa versus 235 aa) and
Mycobacterium bovis (250 aa versus 238 aa)"
/codon_start=1
/transl_table=11
/product="maturase"
/protein_id="YP_976205.1"
/db_xref="GI:121635982"
/db_xref="GeneID:4697847"
/translation="MSSITVSVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDAVVAA
GSDGLTVARIESEIGALEFLNELRTELKSGQFRPQPVRERKIPKPGGLGKVRRLGIPT
VADRVVQAALKLVLEPIFETDFEPVSYGFRPARRAHDTIAEIHLFGTQEYRWVLDADI
KACFDRIDHADLMDRVRHRIKDKRVLRLVNWQRIRHRWNWTDVRRWLTDPTGRWHPIS
ADGITLFNPAAVPIRRYRYRGNTIPTPWTQAV"
misc_feature <109314..109901
/locus_tag="BCG_0102"
/note="Retron-type reverse transcriptase [DNA replication,
recombination, and repair]; Region: COG3344"
/db_xref="CDD:33153"
misc_feature 109425..>109748
/locus_tag="BCG_0102"
/note="RT_G2_intron: Reverse transcriptases (RTs) with
group II intron origin. RT transcribes DNA using RNA as
template. Proteins in this subfamily are found in
bacterial and mitochondrial group II introns. Their most
probable ancestor was a retrotransposable...; Region:
RT_G2_intron; cd01651"
/db_xref="CDD:73157"
misc_feature 109656..109673
/locus_tag="BCG_0102"
/note="putative NTP binding site [chemical binding]; other
site"
/db_xref="CDD:73157"
repeat_region 109977..110291
/note="REP'-1, len: 315 nt. Equivalent to REP', len: 315
nt, from Mycobacterium tuberculosis strain H37Rv, (100.0%
identity in 315 nt overlap). Probable pseudogene fragment,
len: 105 aa; similar to many Mycobacterium tuberculosis
proteins inside REP13E12 elements eg. TR:Q50655
(EMBL:Z95390) MTCY13E12.20 (317 aa), FASTA scores; opt:
324 z-score: 432.5 E(): 6.8e-17, 43.4% identity in 99 aa
overlap, but no possible startsite"
/rpt_family="REP"
gene 110365..111414
/locus_tag="BCG_0103"
/db_xref="GeneID:4697457"
CDS 110365..111414
/locus_tag="BCG_0103"
/codon_start=1
/transl_table=11
/product="glutamine ABC transporter"
/protein_id="YP_976206.1"
/db_xref="GI:121635983"
/db_xref="GeneID:4697457"
/translation="MLFAALRDMQWRKRRLVITIISTGLIFGMTLVLTGLANGFRVEA
RHTVDSMGVDVFVVRSGAAGPFLGSIPFPDVDLARVAAEPGVMAAAPLGSVGTIMKEG
TSTRNVTVFGAPEHGPGMPRVSEGRSPSKPDEVAASSTMGRHLGDTVEVGARRLRVVG
IVPNSTALAKIPNVFLTTEGLQKLAYNGQPNITSIGIIGMPRQLPEGYQTFDRVGAVN
DLVRPLKVAVNSISIVAVLLWIVAVLIVGSVVYLSALERLRDFAVFKAIGTPTRSIMA
GLALQALVIALLAAVVGVVLAQVLAPLFPMIVAVPVGAYLALPVAAIVIGLFASVAGL
KRVVTVDPAQAFGGP"
misc_feature 110377..110955
/locus_tag="BCG_0103"
/note="MacB-like periplasmic core domain; Region:
MacB_PCD; pfam12704"
/db_xref="CDD:221725"
gene 111417..112409
/locus_tag="BCG_0104"
/db_xref="GeneID:4695394"
CDS 111417..112409
/locus_tag="BCG_0104"
/note="In Mycobacterium tuberculosis strain H37Rv, Rv0073
exists as a single gene as in Mycobacterium bovis BCG
Pasteur. In Mycobacterium bovis, a frameshift due to a
single base deletion (a-*) splits Rv0073 into 2 parts,
Mb0074 and Mb0075"
/codon_start=1
/transl_table=11
/product="glutamine ABC transporter ATP-binding protein"
/protein_id="YP_976207.1"
/db_xref="GI:121635984"
/db_xref="GeneID:4695394"
/translation="MGDLSIQNLVVEYYSGGYALRPINGLNLDVAAGSLVMLLGPSGC
GKTTLLSCLGGILRPKSGAIKFDEVDITTLQGAELANYRRNKVGIVFQAFNLVPSLTA
VENVMVPLRSAGMSRRASRRRAEELLARVNLAERMNHRPGDLSGGQQQRVAVARAIAL
DPPLILADEPTAHLDFIQVEEVLRLIRELADGERVVVVATHDSRMLPMADRVVELTPD
FAETNRPPETVHLQAGEVLFEQSTMGDLIYVVSEGEFEIVHELADGGEELVKVAGPGD
YFGEIGVLFHLPRSATVRARSDATAVGYTVQAFRERLGVGGLRDLIEHRALAND"
misc_feature 111426..112061
/locus_tag="BCG_0104"
/note="ATP-binding cassette domain of the transporters
involved in export of lipoprotein and macrolide, and cell
division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255"
/db_xref="CDD:213222"
misc_feature 111426..112061
/locus_tag="BCG_0104"
/note="ABC-type antimicrobial peptide transport system,
ATPase component [Defense mechanisms]; Region: SalX;
COG1136"
/db_xref="CDD:224059"
misc_feature 111534..111557
/locus_tag="BCG_0104"
/note="Walker A/P-loop; other site"
/db_xref="CDD:213222"
misc_feature order(111543..111548,111552..111560,111690..111692,
111918..111923,112017..112019)
/locus_tag="BCG_0104"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:213222"
misc_feature 111681..111692
/locus_tag="BCG_0104"
/note="Q-loop/lid; other site"
/db_xref="CDD:213222"
misc_feature 111846..111875
/locus_tag="BCG_0104"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:213222"
misc_feature 111906..111923
/locus_tag="BCG_0104"
/note="Walker B; other site"
/db_xref="CDD:213222"
misc_feature 111930..111941
/locus_tag="BCG_0104"
/note="D-loop; other site"
/db_xref="CDD:213222"
misc_feature 112005..112025
/locus_tag="BCG_0104"
/note="H-loop/switch region; other site"
/db_xref="CDD:213222"
misc_feature 112065..>112355
/locus_tag="BCG_0104"
/note="cAMP-binding proteins - catabolite gene activator
and regulatory subunit of cAMP-dependent protein kinases
[Signal transduction mechanisms]; Region: Crp; COG0664"
/db_xref="CDD:223736"
misc_feature 112095..112358
/locus_tag="BCG_0104"
/note="effector domain of the CAP family of transcription
factors; members include CAP (or cAMP receptor protein
(CRP)), which binds cAMP, FNR (fumarate and nitrate
reduction), which uses an iron-sulfur cluster to sense
oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
cd00038"
/db_xref="CDD:237999"
misc_feature order(112251..112256,112281..112289)
/locus_tag="BCG_0104"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:237999"
misc_feature 112347..112355
/locus_tag="BCG_0104"
/note="flexible hinge region; other site"
/db_xref="CDD:237999"
gene 112489..113724
/locus_tag="BCG_0105"
/db_xref="GeneID:4698175"
CDS 112489..113724
/locus_tag="BCG_0105"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976208.1"
/db_xref="GI:121635985"
/db_xref="GeneID:4698175"
/translation="MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRIS
AVDFAGSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAGDPHAVLVGRARR
HAAAALRSGITTIRDLGDRDYAALALREEYRQKTTVGPELVVSGPPLTRSGGHCWFLG
GVADSVEELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQ
VGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVWCGMTI
PRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSR
HGFTSTEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVW
RSGTQVPLQASAVGYNTPS"
misc_feature 112501..113700
/locus_tag="BCG_0105"
/note="Imidazolonepropionase and related amidohydrolases
[Secondary metabolites biosynthesis, transport, and
catabolism]; Region: HutI; COG1228"
/db_xref="CDD:224149"
misc_feature 112582..>112722
/locus_tag="BCG_0105"
/note="Superfamily of metallo-dependent hydrolases (also
called amidohydrolase superfamily) is a large group of
proteins that show conservation in their 3-dimensional
fold (TIM barrel) and in details of their active site. The
vast majority of the members have a...; Region:
metallo-dependent_hydrolases; cl00281"
/db_xref="CDD:241750"
misc_feature 112663..113589
/locus_tag="BCG_0105"
/note="Metallo-dependent hydrolases, subgroup A is part of
the superfamily of metallo-dependent hydrolases, a large
group of proteins that show conservation in their
3-dimensional fold (TIM barrel) and in details of their
active site. The vast majority of the...; Region:
Met_dep_hydrolase_A; cd01299"
/db_xref="CDD:238624"
misc_feature order(112708..112710,112714..112716,113164..113166,
113224..113226,113425..113427)
/locus_tag="BCG_0105"
/note="active site"
/db_xref="CDD:238624"
gene 113737..114909
/locus_tag="BCG_0106"
/db_xref="GeneID:4696342"
CDS 113737..114909
/locus_tag="BCG_0106"
/EC_number="2.6.1.-"
/note="Differs from Rv0075 and Mb0077 by 1aa, G326D"
/codon_start=1
/transl_table=11
/product="aminotransferase"
/protein_id="YP_976209.1"
/db_xref="GI:121635986"
/db_xref="GeneID:4696342"
/translation="MQDSIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPA
VLDGVRACVDNEEFGYPPLGEDSLPRATADWCRQRYGWCPRPDWVRVVPDVLKGMEVV
VEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQQDSGRYLLDLDALQAAFVR
GAGSVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGSRHVAAASV
SEAAAEVVVTLVSASKGWNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRAN
IAAYHHGESWLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVGFRALALPS
EPAEYLLSKAKVALSPGIPFGAAVGSGFARLNFATTRAILDRAIEAIAAALRDIID"
misc_feature 113749..114903
/locus_tag="BCG_0106"
/note="Bifunctional PLP-dependent enzyme with
beta-cystathionase and maltose regulon repressor
activities [Amino acid transport and metabolism]; Region:
MalY; COG1168"
/db_xref="CDD:31362"
misc_feature 113824..114885
/locus_tag="BCG_0106"
/note="Aspartate aminotransferase family. This family
belongs to pyridoxal phosphate (PLP)-dependent aspartate
aminotransferase superfamily (fold I). Pyridoxal phosphate
combines with an alpha-amino acid to form a compound
called a Schiff base or aldimine...; Region: AAT_like;
cd00609"
/db_xref="CDD:99734"
misc_feature order(114016..114024,114094..114096,114250..114252,
114343..114345,114427..114429,114433..114438,
114460..114462)
/locus_tag="BCG_0106"
/note="pyridoxal 5'-phosphate binding site [chemical
binding]; other site"
/db_xref="CDD:99734"
misc_feature order(114025..114027,114124..114126,114322..114324,
114454..114462,114550..114552,114559..114561)
/locus_tag="BCG_0106"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:99734"
misc_feature 114436..114438
/locus_tag="BCG_0106"
/note="catalytic residue [active]"
/db_xref="CDD:99734"
gene complement(114924..115313)
/locus_tag="BCG_0107c"
/db_xref="GeneID:4696055"
CDS complement(114924..115313)
/locus_tag="BCG_0107c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976210.1"
/db_xref="GI:121635987"
/db_xref="GeneID:4696055"
/translation="MPAVTTPSNHWGDERRKLSHQPPVRGQILGRRQARRLSQHFARV
GVEAPPKRLQEMLLGAPAADEEWTDVKFALIVTQLNHEKRVAKFHRLQRRATHSLICL
GLVLVALNFLICLAYIFFSLTQHAAAL"
gene complement(115377..116207)
/locus_tag="BCG_0108c"
/db_xref="GeneID:4695393"
CDS complement(115377..116207)
/locus_tag="BCG_0108c"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976211.1"
/db_xref="GI:121635988"
/db_xref="GeneID:4695393"
/translation="MSTIDISAGTIHYEATGPETGRPVVFVHGYMMGGQLWRRVSERL
AGRGLRCIAPTWPLGAHPKPLRPGADQTIGGVAGIVADVLAALELKDVVLVGNDTGGV
VTQLVAVHYPERLGALVLTSCDAFEHFPPPILKPVILAAKSATLFRAAIQVMRAPAAR
NRAYAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLRTEVTTAVAARLPEFDKP
ALIAWSADDVFFALENGQRLAATIPRARFEVIEGARTFSMVDSPDRLADQLSTVAVRT
"
misc_feature complement(115407..116138)
/locus_tag="BCG_0108c"
/note="Alpha/beta hydrolase family; Region: Abhydrolase_6;
pfam12697"
/db_xref="CDD:205026"
gene 116269..116874
/locus_tag="BCG_0109"
/db_xref="GeneID:4698145"
CDS 116269..116874
/locus_tag="BCG_0109"
/note="Differs from Rv0078 by 1aa, V113I"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976212.1"
/db_xref="GI:121635989"
/db_xref="GeneID:4698145"
/translation="MEIKRRTQEERSAATREALITGARKLWGLRGYAEVGTPEIATEA
GVTRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLE
VSGDPEVRQLVLLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPVRPLA
QVLIGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG"
misc_feature 116278..116826
/locus_tag="BCG_0109"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature 116323..116463
/locus_tag="BCG_0109"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene complement(116949..117542)
/locus_tag="BCG_0110c"
/db_xref="GeneID:4696050"
CDS complement(116949..117542)
/locus_tag="BCG_0110c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976213.1"
/db_xref="GI:121635990"
/db_xref="GeneID:4696050"
/translation="MNAVESTLRRVAKDLTGLRQRWALVGGFAVSARSEPRFTRDVDI
VVAVANDDAAESLVRQLLTQQYHLLASVEQDAARRLAAVRLGATADTAANVVVDLLFA
SCGIEPEIAEAAEEIEILPDLVAPVATTAHLIAMKLLARDDDRRPQDRSDLRALVDAA
SPQDIQDARKAIELITLRGFHRDRDLAAEWTRLAAKW"
gene complement(117539..117751)
/locus_tag="BCG_0111c"
/db_xref="GeneID:4697451"
CDS complement(117539..117751)
/locus_tag="BCG_0111c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976214.1"
/db_xref="GI:121635991"
/db_xref="GeneID:4697451"
/translation="MSVAVSVAAQKLRLALDMYEVGEQMQRMRLGRERPNADVVEIEA
AIDAWRMTRPGAEEGDSAGPTSTRFT"
gene 117945..118766
/locus_tag="BCG_0112"
/db_xref="GeneID:4697996"
CDS 117945..118766
/locus_tag="BCG_0112"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976215.1"
/db_xref="GI:121635992"
/db_xref="GeneID:4697996"
/translation="MEPKRSRLVVCAPEPSHAREFPDVAVFSGGRANASQAERLARAV
GRVLADRGVTGGARVRLTMANCADGPTLVQINLQVGDTPLRAQAATAGIDDLRPALIR
LDRQIVRASAQWCPRPWPDRPRRRLTTPAEALVTRRKPVVLRRATPLQAIAAMDAMDY
DVHLFTDAETGEDAVVYRAGPSGLRLARQHHVFPPGWSRCRAPAGPPVPLIVNSRPTP
VLTEAAAVDRAREHGLPFLFFTDQATGRGQLLYSRYDGNLGLITPTGDGVADGLA"
gene 118763..119221
/locus_tag="BCG_0113"
/db_xref="GeneID:4695860"
CDS 118763..119221
/locus_tag="BCG_0113"
/note="Differs from Mb0083 by 1aa, C35R, and from Rv0080
by 2aa, C35R, V60G"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976216.1"
/db_xref="GI:121635993"
/db_xref="GeneID:4695860"
/translation="MSPGSRRASPQSAREVVELDRDEAMRLLASVDHGCVVFTRAALP
AIRPVNHLVVDGRVIVRTRLTAKVSVAVRSSADAGVVVAYEADDLDPRRRTGWSVVVT
GLATEVSDPEQVARYQRLLHPWVNMAMDTVVAIEPEIVTGIRIVADSRTP"
misc_feature 118820..119194
/locus_tag="BCG_0113"
/note="Pyridoxamine 5'-phosphate oxidase; Region:
Pyridox_ox_2; pfam12900"
/db_xref="CDD:205136"
gene 119316..119660
/locus_tag="BCG_0114"
/db_xref="GeneID:4698066"
CDS 119316..119660
/locus_tag="BCG_0114"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976217.1"
/db_xref="GI:121635994"
/db_xref="GeneID:4698066"
/translation="MESEPLYKLKAEFFKTLAHPARIRILELLVERDRSVGELLSSDV
GLESSNLSQQLGVLRRAGVVAARRDGNAMIYSIAAPDIAELLAVARKVLARVLSDRVA
VLEDLRAGGSAT"
misc_feature 119355..119558
/locus_tag="BCG_0114"
/note="Arsenical Resistance Operon Repressor and similar
prokaryotic, metal regulated homodimeric repressors. ARSR
subfamily of helix-turn-helix bacterial transcription
regulatory proteins (winged helix topology). Includes
several proteins that appear to...; Region: HTH_ARSR;
cd00090"
/db_xref="CDD:238042"
misc_feature order(119355..119360,119364..119366,119373..119375,
119382..119387,119394..119399,119406..119408,
119499..119501)
/locus_tag="BCG_0114"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:238042"
misc_feature order(119358..119363,119373..119381,119418..119426,
119454..119465,119469..119474,119481..119486,
119490..119495,119511..119519,119532..119540)
/locus_tag="BCG_0114"
/note="putative DNA binding site [nucleotide binding];
other site"
/db_xref="CDD:238042"
misc_feature order(119418..119420,119427..119429)
/locus_tag="BCG_0114"
/note="putative Zn2+ binding site [ion binding]; other
site"
/db_xref="CDD:238042"
gene 119665..120144
/locus_tag="BCG_0115"
/db_xref="GeneID:4695863"
CDS 119665..120144
/locus_tag="BCG_0115"
/EC_number="1.-.-.-"
/note="Differs from Rv0082 by 1aa, R74Q"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976218.1"
/db_xref="GI:121635995"
/db_xref="GeneID:4695863"
/translation="MGWVAKIFRVGRVVEPAAPLPAAIAEPPAGVRGSLQIRHVDAGS
CNGCEVEISGAFGPVYDAERFGARLVASPRHADALLVTGVVTHNMAGPLRKTLEATPR
PRVVIACGDCALNRGVFADAYGVVGAVGEVVPVDVEIAGCPPTPAAIMAALRSVTGK"
misc_feature 119752..120141
/locus_tag="BCG_0115"
/note="Ni,Fe-hydrogenase III small subunit [Energy
production and conversion]; Region: COG3260"
/db_xref="CDD:225799"
gene 120141..122069
/locus_tag="BCG_0116"
/db_xref="GeneID:4697023"
CDS 120141..122069
/locus_tag="BCG_0116"
/EC_number="1.-.-.-"
/note="In Mycobacterium bovis, a single base transversion
(a-t) leads to a slightly longer product compared to its
homolog in Mycobacterium tuberculosis strain H37Rv (642 aa
versus 640 aa). Differs from Mb0086 by 1aa, A177V"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976219.1"
/db_xref="GI:121635996"
/db_xref="GeneID:4697023"
/translation="MTAAPTAGGVVTSGVGVAGVGVGLLGMFGPVRVVHVGWLLPLSG
VHIELDRLGGFFMALTGAVAAPVGCYLIGYVRREHLGRVPMAVVPLFVAAMLLVPAAG
SVTTFLLAWELMAIASLILVLSEHARPQVRSAGLWYAVMTQLGFIAILVGLVVLAAAG
GSDRFAGLGAVCDGVRAAVFMLTLVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMSAA
MVNLGIYGIVRFDLQLLGPGPRWWGLALLAVGGTSALYGVLQASVAADLKRLLAYSTT
ENMGLITLALGAATLFADTGAYGPASIAAAAAMLHMIAHAAFKSLAFMAAGSVLAATG
LRDLDLLGGLARRMPATTVFFGVAALGACGLPLGAGFVSEWLLVQSLIHAAPGHDPIV
ALTTPLAVGVVALATGLSVAAMTKAFGIGFLARPRSTQAEAAREAPASMRAGMAIAAG
ACLVLAVAPLLVAPMVRRAAATLPAAQAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLA
AALAVAVLARWRFRRRPAPARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVLRPD
TDIEVTHTAESRYMAERITYRTAVADAIEQRLYTPVVGAVAAMAELLRRAHTGSVHRY
LAYGALGVLIVLVVARCT"
misc_feature 120258..122012
/locus_tag="BCG_0116"
/note="hydrogenase 4 subunit B; Validated; Region:
PRK06521"
/db_xref="CDD:180602"
misc_feature 120441..121283
/locus_tag="BCG_0116"
/note="NADH-Ubiquinone/plastoquinone (complex I), various
chains; Region: Oxidored_q1; pfam00361"
/db_xref="CDD:201180"
gene 122069..123019
/gene="hycD"
/locus_tag="BCG_0117"
/db_xref="GeneID:4695375"
CDS 122069..123019
/gene="hycD"
/locus_tag="BCG_0117"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="formate hydrogenlyase hycD (FHL)"
/protein_id="YP_976220.1"
/db_xref="GI:121635997"
/db_xref="GeneID:4695375"
/translation="MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRAGAGLLQPWR
DLLKQLGKQQITPAGTTIVFAAAPVIVAGTTLLIAAIAPLVATGSPLDPSADLFAVVG
LLFLGTVALTLAGIDTGTSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGAL
VASTIDHPGHVVSLAGVLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAG
PRLALVEWAAGMRLTVLLALLANLFLPWGIAGAAPTALDVLTGVVAVAAKVAILAVLL
ATFEVFLAKLRLFRVPELLAGSFLLALLAVTAANFFTVGA"
misc_feature 122069..122947
/gene="hycD"
/locus_tag="BCG_0117"
/note="Formate hydrogenlyase subunit 4 [Energy production
and conversion]; Region: HyfC; COG0650"
/db_xref="CDD:30995"
gene 123030..123692
/gene="hycP"
/locus_tag="BCG_0118"
/db_xref="GeneID:4697265"
CDS 123030..123692
/gene="hycP"
/locus_tag="BCG_0118"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="hydrogenase hycP"
/protein_id="YP_976221.1"
/db_xref="GI:121635998"
/db_xref="GeneID:4697265"
/translation="MSNANFSILVDFAAGGLVLASVLIVWRRDLRAIVRLLAWQGAAL
AAIPLLRGIRDNDRALIAVGIAVLALRALVLPWLLARAVGAEAAAQREATPLVNTASS
LLITAGLTLTAFAITQPVVNLEPGVTINAVPAAFAVVLIALFVMTTRLHAVSQAAGFL
MLDNGIAATAFLLTAGVPLIVELGASLDVLFAVIVIGVLTGRLRRIFGDADLDKLREL
RD"
misc_feature 123036..123689
/gene="hycP"
/locus_tag="BCG_0118"
/note="Hydrogenase 4 membrane component (E) [Energy
production and conversion]; Region: HyfE; COG4237"
/db_xref="CDD:226688"
gene 123692..125158
/gene="hycQ"
/locus_tag="BCG_0119"
/db_xref="GeneID:4697267"
CDS 123692..125158
/gene="hycQ"
/locus_tag="BCG_0119"
/EC_number="1.-.-.-"
/note="Differs from Rv0086 by 1aa, T118M"
/codon_start=1
/transl_table=11
/product="hydrogenase hycQ"
/protein_id="YP_976222.1"
/db_xref="GI:121635999"
/db_xref="GeneID:4697267"
/translation="MTGLLLAAILAPLAASIASLITGWRRTTATLTALSATTVLACAV
AMGFWMGSGAQFGLGGLLRADALTVVMLVVIGIVGTLATAASIGYIDTELAHGHIDGR
SARLYGVLTPAFLCATVLAVCANNIGVIWVAIEATTVITAFLVGHRRTRTALEATWKY
VVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLL
IGYGAKAGLFPFHTWLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAY
LRNGLLVVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLL
HVLAHGIGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVGLIVLLGLPPF
AMFASELAIARSLANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPAITVP
ATAAAALMVGIVVSAALGITAGPLADLLGIAASNVGLP"
misc_feature 124061..124894
/gene="hycQ"
/locus_tag="BCG_0119"
/note="NADH-Ubiquinone/plastoquinone (complex I), various
chains; Region: Oxidored_q1; pfam00361"
/db_xref="CDD:201180"
gene 125155..126633
/gene="hycE"
/locus_tag="BCG_0120"
/db_xref="GeneID:4697268"
CDS 125155..126633
/gene="hycE"
/locus_tag="BCG_0120"
/EC_number="1.-.-.-"
/note="Differs from Rv0087 by 1aa, I230V"
/codon_start=1
/transl_table=11
/product="formate hydrogenase hycQ (FHL)"
/protein_id="YP_976223.1"
/db_xref="GI:121636000"
/db_xref="GeneID:4697268"
/translation="MMSASWLRHRVSERGLIATAEQLWADSFRLALVAAHDDGDSLRV
VYLFLAGYPDRRVELEYVVPADNPEIRSLAYLSFPAGRFEREMADLYGIRPVGHPKPR
RLVRHAHWPDWHPMRTDAGPAPEFTDTGAFPFLAVEGPGVYEIPVGPVHAGLIEPGHF
RFSVAGETIVRLKARLWFVHRGIEKLFHGRPATAAVDLAERISGDTSAAHALAHSLAI
EDALGIELPHEIHRLRALIVELERLYNHAADLGALANDVGYSLANAHAQRIRENLLRR
NAAVTGHRLLRGAIRAGGVALRALPDTDELAALAVDLAEVATLTLANSVVYDRFAGTA
VLHPDDASALGCLGYVARASGLRSDARVEHPTIVLPITEIGAPDGDVLARYTVRRDEF
AASAALAQHIVESHTGPIEYAATLHPVGAPSSGIGIVEGWRGTIVHRVEIDVDGRITR
AKVVDPSWFNWPALPVAMADTIVPDFPLANKSFNQSYAGNDL"
misc_feature 125155..125547
/gene="hycE"
/locus_tag="BCG_0120"
/note="Ni,Fe-hydrogenase III component G [Energy
production and conversion]; Region: HycE; COG3262"
/db_xref="CDD:33073"
misc_feature 125557..126630
/gene="hycE"
/locus_tag="BCG_0120"
/note="Nickel-dependent hydrogenase; Region: NiFeSe_Hases;
cl00417"
/db_xref="CDD:214065"
misc_feature 125581..126585
/gene="hycE"
/locus_tag="BCG_0120"
/note="NADH:ubiquinone oxidoreductase 49 kD subunit 7
[Energy production and conversion]; Region: NuoD; COG0649"
/db_xref="CDD:30994"
gene 126668..127342
/locus_tag="BCG_0121"
/db_xref="GeneID:4697266"
CDS 126668..127342
/locus_tag="BCG_0121"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976224.1"
/db_xref="GI:121636001"
/db_xref="GeneID:4697266"
/translation="MSVYKHAPSRVRLRQTRSTVVKGRSGSLSWRRVRTGDLGLAVWG
GREEYRAVKPGTPGIQPKGDMMTVTVVDAGPGRVSRSVEVAAPAAELFAIVADPRRHR
ELDGSGTVRGNIKVPAKLVVGSKFSTKMKLFGLPYRITSRVTALKPNELVEWSHPLGH
RWRWEFESLSPTLTRVTETFDYHAAGAIKNGLKFYEMTGFAKSNAAGIEATLAKLSDQ
YARGRA"
misc_feature 126896..127309
/locus_tag="BCG_0121"
/note="Ligand-binding SRPBCC domain of an uncharacterized
subfamily of proteins; Region: SRPBCC_7; cd07825"
/db_xref="CDD:176867"
misc_feature order(126899..126901,126905..126907,126911..126913,
126938..126946,126950..126955,126986..126988,
127019..127021,127025..127027,127031..127033,
127037..127039,127088..127090,127094..127096,
127112..127114,127118..127120,127157..127162,
127166..127168,127172..127174,127193..127195,
127199..127201,127205..127207,127211..127213,
127247..127261,127265..127273,127277..127285,
127292..127294)
/locus_tag="BCG_0121"
/note="putative hydrophobic ligand binding site [chemical
binding]; other site"
/db_xref="CDD:176867"
gene 127499..128092
/locus_tag="BCG_0122"
/db_xref="GeneID:4695770"
CDS 127499..128092
/locus_tag="BCG_0122"
/EC_number="2.1.1.-"
/codon_start=1
/transl_table=11
/product="methyltransferase/methylase"
/protein_id="YP_976225.1"
/db_xref="GI:121636002"
/db_xref="GeneID:4695770"
/translation="MDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRI
PYVTAVDIDAPVLRRAQTRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIEDTR
TALSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHSAPIKWP
PPQTLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV"
misc_feature 127574..127870
/locus_tag="BCG_0122"
/note="S-adenosylmethionine-dependent methyltransferases
(SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
that use S-adenosyl-L-methionine (SAM or AdoMet) as a
substrate for methyltransfer, creating the product
S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
cd02440"
/db_xref="CDD:100107"
misc_feature order(127583..127603,127649..127654,127718..127726,
127772..127774)
/locus_tag="BCG_0122"
/note="S-adenosylmethionine binding site [chemical
binding]; other site"
/db_xref="CDD:100107"
gene 128221..128991
/locus_tag="BCG_0123"
/db_xref="GeneID:4695984"
CDS 128221..128991
/locus_tag="BCG_0123"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976226.1"
/db_xref="GI:121636003"
/db_xref="GeneID:4695984"
/translation="MAKNQNRIRNRWELITCGLGGHVTYAPDDAALAARLRASTGLGE
VWRCLRCGDFALGGPQGRGAPEDAPLIMRGKALRQAIIIRALGVERLVRALVLALAAW
AVWEFRGARGAIQATLDRDLPVLRAAGFKVDQMTVIHALEKALAAKPSTLALITGMLA
AYAVLQAVEGVGLWLLKRWGEYFAVVATSIFLPLEVHDLAKGITTTRVVTFSINVAAV
VYLLISKRLFGVRGGRKAYDVERRGEQLLDLERAAMLT"
misc_feature 128539..128934
/locus_tag="BCG_0123"
/note="Predicted membrane protein [Function unknown];
Region: COG3305"
/db_xref="CDD:225842"
gene 129425..130192
/gene="mtn"
/locus_tag="BCG_0124"
/db_xref="GeneID:4697519"
CDS 129425..130192
/gene="mtn"
/locus_tag="BCG_0124"
/EC_number="3.2.2.16"
/EC_number="3.2.2.9"
/codon_start=1
/transl_table=11
/product="bifunctional MTA/SAH nucleosidase mtn"
/protein_id="YP_976227.1"
/db_xref="GI:121636004"
/db_xref="GeneID:4697519"
/translation="MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHR
VVLAAAGMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDF
GLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGR
QPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRAL
SDLAGADSGVDFNRFVGEVAASSARVLLRLLPVLTAC"
misc_feature 129434..130126
/gene="mtn"
/locus_tag="BCG_0124"
/note="Phosphorylase superfamily; Region: PNP_UDP_1;
cl00303"
/db_xref="CDD:241766"
misc_feature 129437..130126
/gene="mtn"
/locus_tag="BCG_0124"
/note="5'-methylthioadenosine/S-adenosylhomocysteine
nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704"
/db_xref="CDD:130765"
gene 130324..132609
/gene="ctpA"
/locus_tag="BCG_0125"
/db_xref="GeneID:4697738"
CDS 130324..132609
/gene="ctpA"
/locus_tag="BCG_0125"
/EC_number="3.6.3.-"
/note="Differs from Rv0092 by 1aa, A3T"
/codon_start=1
/transl_table=11
/product="cation transporter p-type atpase A ctpA"
/protein_id="YP_976228.1"
/db_xref="GI:121636005"
/db_xref="GeneID:4697738"
/translation="MTAAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRA
AVNFGTRVATIDTSEAVDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRL
AIAAVLFVPVADLSVMFGVVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHH
AASMETLISVGITAATIWSLYTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVL
VGRYFEARAKSQAGSALRALAALSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQI
VAADGLAVDGSAAVDMSAMTGEAKPTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQF
AGMVRLVEQAQAQKADAQRLADRISSVFVPAVLVIAALTAAGWLIAGGQPDRAVSAAL
AVLVIACPCALGLATPTAMMVASGRGAQLGIFLKGYKSLEATRAVDTVVFDKTGTLTT
GRLQVSAVTAAPGWEADQVLALAATVEAASEHSVALAIAAATTRRDAVTDFRAIPGRG
VSGTVSGRAVRVGKPSWIGSSSCHPNMRAARRHAESLGETAVFVEVDGEPCGVIAVAD
AVKDSARDAVAALADRGLRTMLLTGDNPESAAAVATRVGIDEVIADILPEGKVDVIEQ
LRDRGHVVAMVGDGINDGPALARADLGMAIGRGTDVAIGAADIILVRDHLDVVPLALD
LARATMRTVKLNMVWAFGYNIAAIPVAAAGLLNPLVAGAAMAFSSFFVVSNSLRLRKF
GRYPLGCGTVGGPQMTAPSSA"
misc_feature 130360..132549
/gene="ctpA"
/locus_tag="BCG_0125"
/note="Cation transport ATPase [Inorganic ion transport
and metabolism]; Region: ZntA; COG2217"
/db_xref="CDD:225127"
misc_feature 130372..130554
/gene="ctpA"
/locus_tag="BCG_0125"
/note="Heavy-metal-associated domain (HMA) is a conserved
domain of approximately 30 amino acid residues found in a
number of proteins that transport or detoxify heavy
metals, for example, the CPx-type heavy metal ATPases and
copper chaperones. HMA domain...; Region: HMA; cd00371"
/db_xref="CDD:238219"
misc_feature order(130390..130398,130405..130407)
/gene="ctpA"
/locus_tag="BCG_0125"
/note="metal-binding site [ion binding]"
/db_xref="CDD:238219"
misc_feature 130960..131622
/gene="ctpA"
/locus_tag="BCG_0125"
/note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122"
/db_xref="CDD:215733"
misc_feature 131989..132378
/gene="ctpA"
/locus_tag="BCG_0125"
/note="Soluble P-type ATPase [General function prediction
only]; Region: COG4087"
/db_xref="CDD:226572"
gene complement(132556..133404)
/locus_tag="BCG_0126c"
/db_xref="GeneID:4697724"
CDS complement(132556..133404)
/locus_tag="BCG_0126c"
/note="Differs from Rv0093c by 1aa, R22C"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976229.1"
/db_xref="GI:121636006"
/db_xref="GeneID:4697724"
/translation="MLAQATTAGSFNHHASTVLQGRRGVPAAMWSEPAGAIRRHCATI
DGMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAES
RPVVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPT
GAGTHLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAV
STTRILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWP
TDGSAA"
misc_feature complement(132559..133269)
/locus_tag="BCG_0126c"
/note="Predicted integral membrane protein [Function
unknown]; Region: COG5660"
/db_xref="CDD:227947"
misc_feature complement(133153..133260)
/locus_tag="BCG_0126c"
/note="Putative zinc-finger; Region: zf-HC2; pfam13490"
/db_xref="CDD:222172"
gene complement(133451..134404)
/locus_tag="BCG_0127c"
/db_xref="GeneID:4696049"
CDS complement(133451..134404)
/locus_tag="BCG_0127c"
/note="Differs from Rv0094c by 3aa, D256E, W296R, K315E"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976230.1"
/db_xref="GI:121636007"
/db_xref="GeneID:4696049"
/translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTE
RARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTP
DAAAIDRDTRSQAQRNHDGLLAGLRALIASGELGQHNGLPVSIVVTTTLTDLQTGAGK
GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIM
LFANDRGCTKPGCDAPAYHSQAHHVTGWTSTGRTDITDLTLACDPDNRLAEKGWTTRK
NTHGHTEWLPPPHLDHGQPWTNTFHHPERFLHNQDDDDKPD"
misc_feature complement(133736..>134404)
/locus_tag="BCG_0127c"
/note="Domain of unknown function (DUF222); Region:
DUF222; pfam02720"
/db_xref="CDD:202360"
misc_feature complement(133604..133768)
/locus_tag="BCG_0127c"
/note="HNH nucleases; HNH endonuclease signature which is
found in viral, prokaryotic, and eukaryotic proteins. The
alignment includes members of the large group of homing
endonucleases, yeast intron 1 protein, MutS, as well as
bacterial colicins, pyocins, and...; Region: HNHc;
cd00085"
/db_xref="CDD:28969"
misc_feature complement(order(133610..133612,133619..133624,
133634..133639,133670..133672,133676..133684,
133688..133690))
/locus_tag="BCG_0127c"
/note="active site"
/db_xref="CDD:28969"
repeat_region complement(133454..134957)
/note="REP-2, len: 1504 nt. Equivalent to REP, len: 1503
nt, from Mycobacterium tuberculosis strain H37Rv, (97.0%
identity in 1504 nt overlap). REP251, member of REP13E12
family"
/rpt_family="REP"
gene complement(134175..134957)
/locus_tag="BCG_0128c"
/db_xref="GeneID:4698785"
CDS complement(134175..134957)
/locus_tag="BCG_0128c"
/note="In Mycobacterium tuberculosis strain H37Rv, Rv0095c
and Rv1588 exist as separate genes in their respective
positions. In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a 73 bp substitution leads to a
single combined gene. Differs from Rv0095c by 5aa, E57D,
T70S, V85A, V91G, A92Q"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976231.1"
/db_xref="GI:121636008"
/db_xref="GeneID:4698785"
/translation="MRYLPVSTRRIWVNPLCHFSFTVISGALFVSARRYDSNMLANSR
EELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHTLINQLDTQ
ASEEELGGTLCCALANRLRITKPDAALRIADAADLGPRRALTGEPLAPQLTATATAQR
QGLIGEAHIKVIRALFRPPARRGGCVHPPGRRSRPGRQSRSISSRRAGPLRPAGHGLA
TPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL"
misc_feature complement(<134436..134693)
/locus_tag="BCG_0128c"
/note="Domain of unknown function (DUF222); Region:
DUF222; pfam02720"
/db_xref="CDD:202360"
gene 135066..136457
/gene="PPE1"
/locus_tag="BCG_0129"
/db_xref="GeneID:4697111"
CDS 135066..136457
/gene="PPE1"
/locus_tag="BCG_0129"
/note="Differs from Rv0096 by 1aa, W182R"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976232.1"
/db_xref="GI:121636009"
/db_xref="GeneID:4697111"
/translation="MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQ
LLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMP
TPAELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATV
AVPSTQPAPPIRAPGGDAADTWLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSP
AVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLL
PIAAALGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISY
AVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRD
EFLDATATVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTV
PLLPTTWTTDAEQ"
misc_feature 135066..>135488
/gene="PPE1"
/locus_tag="BCG_0129"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:35210"
misc_feature 135069..135488
/gene="PPE1"
/locus_tag="BCG_0129"
/note="PPE family; Region: PPE; pfam00823"
/db_xref="CDD:189731"
gene 136476..137345
/locus_tag="BCG_0130"
/db_xref="GeneID:4696160"
CDS 136476..137345
/locus_tag="BCG_0130"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976233.1"
/db_xref="GI:121636010"
/db_xref="GeneID:4696160"
/translation="MTLKVKGEGLGAQVTGVDPKNLDDITTDEIRDIVYTNKLVVLKD
VHPSPREFIKLGRIIGQIVPYYEPMYHHEDHPEIFVSSTEEGQGVPKTGAFWHIDYMF
MPEPFAFSMVLPLAVPGHDRGTYFIDLARVWQSLPAAKRDPARGTVSTHDPRRHIKIR
PSDVYRPIGEVWDEINRTTPPIKWPTVIRHPKTGQEILYICATGTTKIEDKDGNPVDP
EVLQELMAATGQLDPEYQSPFIHTQHYQVGDIILWDNRVLMHRAKHGSAAGTLTTYRL
TMLDGLKTPGYAA"
misc_feature 136476..137339
/locus_tag="BCG_0130"
/note="Probable taurine catabolism dioxygenase [Secondary
metabolites biosynthesis, transport, and catabolism];
Region: TauD; COG2175"
/db_xref="CDD:225086"
misc_feature 136494..137264
/locus_tag="BCG_0130"
/note="Taurine catabolism dioxygenase TauD, TfdA family;
Region: TauD; pfam02668"
/db_xref="CDD:217174"
gene 137342..137893
/locus_tag="BCG_0131"
/db_xref="GeneID:4697693"
CDS 137342..137893
/locus_tag="BCG_0131"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976234.1"
/db_xref="GI:121636011"
/db_xref="GeneID:4697693"
/translation="MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDA
QYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVL
RGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCV
IEFWDENGGAASGEIELAALNIP"
misc_feature 137423..137878
/locus_tag="BCG_0131"
/note="FcoT-like thioesterase domain; Region: FcoT;
pfam10862"
/db_xref="CDD:151311"
gene 137898..139520
/gene="fadD10"
/locus_tag="BCG_0132"
/db_xref="GeneID:4697870"
CDS 137898..139520
/gene="fadD10"
/locus_tag="BCG_0132"
/EC_number="2.3.1.86"
/note="activates fatty acids by binding to coenzyme A"
/codon_start=1
/transl_table=11
/product="acyl-CoA synthetase"
/protein_id="YP_976235.1"
/db_xref="GI:121636012"
/db_xref="GeneID:4697870"
/translation="MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRY
RELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPI
AAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASL
AGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTY
SPLPATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVS
ELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDG
SIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNP
ERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGV
REAACYEIPDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVI
VTDIPRTQSGKVMRASLAAAATADKARVVVRG"
misc_feature 137898..139454
/gene="fadD10"
/locus_tag="BCG_0132"
/note="acyl-CoA synthetase; Validated; Region: PRK05857"
/db_xref="CDD:180293"
misc_feature 137955..>138455
/gene="fadD10"
/locus_tag="BCG_0132"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:247692"
misc_feature 138405..139454
/gene="fadD10"
/locus_tag="BCG_0132"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cd04433"
/db_xref="CDD:213270"
misc_feature order(138417..138419,138426..138443,138447..138452)
/gene="fadD10"
/locus_tag="BCG_0132"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213270"
misc_feature order(138417..138419,138426..138443,138447..138452)
/gene="fadD10"
/locus_tag="BCG_0132"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213270"
misc_feature order(138426..138428,138777..138782,138840..138857,
139119..139121,139155..139157,139164..139166,
139197..139199,139452..139454)
/gene="fadD10"
/locus_tag="BCG_0132"
/note="AMP binding site [chemical binding]; other site"
/db_xref="CDD:213270"
misc_feature order(138426..138428,138558..138563,138696..138698,
138702..138707,138714..138716,138777..138782,
138840..138857,139119..139121,139155..139157,
139164..139166,139188..139199,139395..139397)
/gene="fadD10"
/locus_tag="BCG_0132"
/note="active site"
/db_xref="CDD:213270"
misc_feature order(138558..138560,138702..138707,138714..138716,
138777..138779,139188..139196,139377..139379,
139395..139397)
/gene="fadD10"
/locus_tag="BCG_0132"
/note="CoA binding site [chemical binding]; other site"
/db_xref="CDD:213270"
gene 139525..139761
/locus_tag="BCG_0133"
/db_xref="GeneID:4695648"
CDS 139525..139761
/locus_tag="BCG_0133"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976236.1"
/db_xref="GI:121636013"
/db_xref="GeneID:4695648"
/translation="MRDRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQ
LGVNRQSELPSRLAANPSIAGWLRELEAVCTEFG"
misc_feature 139531..139734
/locus_tag="BCG_0133"
/note="Phosphopantetheine attachment site; Region:
PP-binding; pfam00550"
/db_xref="CDD:215989"
gene 139743..147281
/gene="nrp"
/locus_tag="BCG_0134"
/db_xref="GeneID:4696972"
CDS 139743..147281
/gene="nrp"
/locus_tag="BCG_0134"
/EC_number="6.-.-.-"
/codon_start=1
/transl_table=11
/product="peptide synthetase nrp"
/protein_id="YP_976237.1"
/db_xref="GI:121636014"
/db_xref="GeneID:4696972"
/translation="MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRLELARFLA
ALHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADEHLQSTWCSGILGKPL
VRHTVHTDPNGYVTGLDVHTHHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAK
LREAHRRETAKVEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATI
CGNAFDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVA
TCLVNSVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVE
ALTLNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWNRADLP
ACKTHPKVAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAW
FLDSARGVHQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGC
GYSVCDTADEISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTH
DALLATKTAYIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTS
DISVEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADGD
AIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIV
CDQTTMDGALLRLGRPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSR
RRAFATGDRVTVDAEGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELH
SGSLGVWFKSQRTREGEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDN
LPRLPQWSAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILPE
TRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQR
RLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPR
QLVIEARRADLGCDIVDATAWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEH
VLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGD
LDDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRGASLVVDWPASVQQQVR
RIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLVL
RVNLAGDPSFAELLGQVRARSLAAYENQDVPFEVLVDRLKPTRAMTHHPLIQVMLAWQ
DNPVGQLNLGDLQATPMPIDTRTARMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEA
QAIDVLIERLRKVLVAVAAAPERTVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSI
PQMLAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERC
APAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAGHDLPI
IDVVDALAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHRNVTRLFASLPARLS
AAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEHVSVLTQ
TPAAVAMLPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTICAAISAPL
RPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRAGLTASRF
VACPFGGSGARMYRTGDLVCWRADGQLEFLGRTDDQVKIRGYRIELGEVATALAELAG
VGQAVVIAREDRPGDKRLVGYATEIAPGAVDPAGLRAQLAQRLPGYLVPAAVVVIDAL
PLTVNGKLDHRALPAPEYGDTNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELG
GDSLAAMRVIAAINTTLNADLPVRALLHASSTRGLSQLLGRDARPTSDPRLVSVHGDN
PTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLD
VDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGDKSEPDLGL
DQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGTAELIRIALTTKLKPFTYVST
ADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSKWAGEVLLREANDLCALPVA
VFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLP
VTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGLDEYVDWLIEAGYPIRRIDDF
AEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTRGCSAPTDRFRAAVRAA
KVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL"
misc_feature 141159..142301
/gene="nrp"
/locus_tag="BCG_0134"
/note="AMP-binding enzyme; Region: AMP-binding; pfam00501"
/db_xref="CDD:201270"
misc_feature 141159..>141608
/gene="nrp"
/locus_tag="BCG_0134"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:213459"
misc_feature 141414..142301
/gene="nrp"
/locus_tag="BCG_0134"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:213459"
misc_feature order(141471..141473,141480..141497,141501..141506)
/gene="nrp"
/locus_tag="BCG_0134"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213270"
misc_feature order(141471..141473,141480..141497,141501..141506)
/gene="nrp"
/locus_tag="BCG_0134"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213270"
misc_feature order(141480..141482,141600..141605,141750..141752,
141756..141761,141768..141770,141834..141839,
141909..141926,142158..142160,142194..142196,
142203..142205,142227..142238)
/gene="nrp"
/locus_tag="BCG_0134"
/note="active site"
/db_xref="CDD:213270"
misc_feature order(141480..141482,141834..141839,141909..141926,
142158..142160,142194..142196,142203..142205,
142236..142238)
/gene="nrp"
/locus_tag="BCG_0134"
/note="AMP binding site [chemical binding]; other site"
/db_xref="CDD:213270"
misc_feature order(141600..141602,141756..141761,141768..141770,
141834..141836,142227..142235)
/gene="nrp"
/locus_tag="BCG_0134"
/note="CoA binding site [chemical binding]; other site"
/db_xref="CDD:213270"
misc_feature 142554..142736
/gene="nrp"
/locus_tag="BCG_0134"
/note="Phosphopantetheine attachment site; Region:
PP-binding; pfam00550"
/db_xref="CDD:201300"
misc_feature 142809..143714
/gene="nrp"
/locus_tag="BCG_0134"
/note="Condensation domain; Region: Condensation;
pfam00668"
/db_xref="CDD:144314"
misc_feature 143778..144080
/gene="nrp"
/locus_tag="BCG_0134"
/note="HxxPF-repeated domain; Region: HxxPF_rpt;
pfam13745"
/db_xref="CDD:205919"
misc_feature 144258..145655
/gene="nrp"
/locus_tag="BCG_0134"
/note="The adenylation domain of nonribosomal peptide
synthetases (NRPS); Region: A_NRPS; cd05930"
/db_xref="CDD:213296"
misc_feature 144297..145460
/gene="nrp"
/locus_tag="BCG_0134"
/note="amino acid adenylation domain; Region:
AA-adenyl-dom; TIGR01733"
/db_xref="CDD:213649"
misc_feature order(144648..144650,144657..144674,144678..144683)
/gene="nrp"
/locus_tag="BCG_0134"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213296"
misc_feature order(144657..144662,144984..144989,145041..145058,
145119..145121,145317..145319,145353..145355,
145362..145364,145635..145637)
/gene="nrp"
/locus_tag="BCG_0134"
/note="AMP binding site [chemical binding]; other site"
/db_xref="CDD:213296"
misc_feature 145713..145907
/gene="nrp"
/locus_tag="BCG_0134"
/note="Phosphopantetheine attachment site; Region:
PP-binding; pfam00550"
/db_xref="CDD:201300"
misc_feature 146064..147278
/gene="nrp"
/locus_tag="BCG_0134"
/note="Putative dehydrogenase domain of multifunctional
non-ribosomal peptide synthetases and related enzymes
[Secondary metabolites biosynthesis, transport, and
catabolism]; Region: COG3320"
/db_xref="CDD:33129"
misc_feature 146067..147017
/gene="nrp"
/locus_tag="BCG_0134"
/note="extended (e) SDRs, subgroup 1; Region: SDR_e1;
cd05235"
/db_xref="CDD:187546"
misc_feature order(146082..146084,146088..146099,146163..146171,
146364..146372,146409..146411,146478..146486,
146589..146591,146601..146603,146670..146681)
/gene="nrp"
/locus_tag="BCG_0134"
/note="putative NAD(P) binding site [chemical binding];
other site"
/db_xref="CDD:187546"
misc_feature order(146412..146414,146484..146486,146589..146591,
146601..146603)
/gene="nrp"
/locus_tag="BCG_0134"
/note="active site"
/db_xref="CDD:187546"
misc_feature order(146484..146486,146589..146591,146676..146678,
146724..146726,146757..146759)
/gene="nrp"
/locus_tag="BCG_0134"
/note="putative substrate binding site [chemical binding];
other site"
/db_xref="CDD:187546"
gene 147456..149441
/locus_tag="BCG_0135"
/db_xref="GeneID:4699183"
CDS 147456..149441
/locus_tag="BCG_0135"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976238.1"
/db_xref="GI:121636015"
/db_xref="GeneID:4699183"
/translation="MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLV
SGARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAA
AFRIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWI
VAAICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVF
AVAFATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFA
RLGLLAGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAP
RFLTHAFTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRR
GNSWPVGRLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGP
VTLALRVLPVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLF
DTFVRYHWGHEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFG
IALMTMSSTVGATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWAR
QDRRVASREDRHADSDYADDELEAYNAMLRELSRMRR"
misc_feature 148521..149438
/locus_tag="BCG_0135"
/note="Predicted membrane protein [Function unknown];
Region: COG3336"
/db_xref="CDD:33145"
gene complement(149657..151915)
/gene="ctpB"
/locus_tag="BCG_0136c"
/db_xref="GeneID:4697602"
CDS complement(149657..151915)
/gene="ctpB"
/locus_tag="BCG_0136c"
/EC_number="3.6.3.-"
/note="Differs from Rv0103c by 1aa, S22L"
/codon_start=1
/transl_table=11
/product="cation-transporter P-type atpase B ctpB"
/protein_id="YP_976239.1"
/db_xref="GI:121636016"
/db_xref="GeneID:4697602"
/translation="MAAPVVGDADLQSVRRIRLDVSGMSCAACASRVETKLNKIPGVR
ASVNFATRVATIDAVGMAADELCGVVEKAGYHAAPHTETTVLDKRTKDPDGAHARRLL
RRLLVAAVLFVPLADLSTLFAIVPSARVPGWGYILTALAAPVVTWAAWPFHSVALRNA
RHRTTSMETLISVGIVAATAWSLSSVFGDQPPREGSGIWRAILNSDSIYLEVAAGVTV
FVLAGRYFEARAKSKAGSALRALAELGAKNVAVLLPDGAELVIPASELKKRQRFVTRP
GETIAADGVVVDGSAAIDMSAMTGEAKPVRAYPAASVVGGTVVMDGRLVIEATAVGAD
TQFAAMVRLVEQAQTQKARAQRLADHIAGVFVPVVFVIAGLAGAAWLVSGAGADRAFS
VTLGVLVIACPCALGLATPTAMMVASGRGAQLGIFIKGYRALETIRSIDTVVFDKTGT
LTVGQLAVSTVTMAGSGTSERDREEVLGLAAAVESASEHAMAAAIVAASPDPGPVNGF
VAVAGCGVSGEVGGHHVEVGKPSWITRTTPCHDAALVSARLDGESRGETVVFVSVDGV
VRAALTIADTLKDSAAAAVAALRSRGLRTILLTGDNRAAADAVAAQVGIDSAVADMLP
EGKVDVIQRLREEGHTVAMVGDGINDGPALVGADLGLAIGRGTDVALGAADIILVRDD
LNTVPQALDLARATMRTIRMNMIWAFGYNVAAIPIAAAGLLNPLIAGAAMAFSSFFVV
SNSLRLRNFGAQ"
misc_feature complement(149669..151876)
/gene="ctpB"
/locus_tag="BCG_0136c"
/note="Cation transport ATPase [Inorganic ion transport
and metabolism]; Region: ZntA; COG2217"
/db_xref="CDD:225127"
misc_feature complement(151682..151861)
/gene="ctpB"
/locus_tag="BCG_0136c"
/note="Heavy-metal-associated domain (HMA) is a conserved
domain of approximately 30 amino acid residues found in a
number of proteins that transport or detoxify heavy
metals, for example, the CPx-type heavy metal ATPases and
copper chaperones. HMA domain...; Region: HMA; cd00371"
/db_xref="CDD:238219"
misc_feature complement(order(151829..151831,151838..151846))
/gene="ctpB"
/locus_tag="BCG_0136c"
/note="metal-binding site [ion binding]"
/db_xref="CDD:238219"
misc_feature complement(150608..151270)
/gene="ctpB"
/locus_tag="BCG_0136c"
/note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122"
/db_xref="CDD:215733"
misc_feature complement(149882..>150121)
/gene="ctpB"
/locus_tag="BCG_0136c"
/note="Soluble P-type ATPase [General function prediction
only]; Region: COG4087"
/db_xref="CDD:226572"
gene 152059..153573
/locus_tag="BCG_0137"
/db_xref="GeneID:4697687"
CDS 152059..153573
/locus_tag="BCG_0137"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976240.1"
/db_xref="GI:121636017"
/db_xref="GeneID:4697687"
/translation="MTPVTTFPLVDAILAGRDRNLDGVILIAAQHLLQTTHAMLRSLF
RVGLDPRNVAVIGKCYSTHPGVVDAMRADGIYVDDCSDAYAPHESFDTQYTRHVEWFF
AESWARLTAGRTARVVLLDDGGSLLAVAGAMLDASADVIGIEQTSAGYAKIVGCALGF
PVINIARSSAKLLYESPIIAARVTQTAFERTAGIDSSAAILITGAGAIGTALADVLRP
LHDRVDVYDTRSGCMTPIDLPNAIGGYDVIIGATGATSVPASMHELLRPGVLLMSASS
SDREFDAVALRRRTTPNPDCHADLRVADGSVDATLLNSGFPVNFDGSPMCGDASMALT
MALLAAAVLYASVAVADEMSSDHPHLGLIDQGDIVASFLNIDVPLQALSRLPLLSIDG
YRRLQVRSGHTLFRQGERADHFFVIESGELEALVDGKVILRLGAGDHFGEACLLGGMR
RIATVRACEPSVLWELDGKAFGDALHGDAAMREIAYGVARTRLMHAGASESLMV"
misc_feature 153172..>153567
/locus_tag="BCG_0137"
/note="cAMP-binding proteins - catabolite gene activator
and regulatory subunit of cAMP-dependent protein kinases
[Signal transduction mechanisms]; Region: Crp; COG0664"
/db_xref="CDD:31008"
misc_feature 153190..153504
/locus_tag="BCG_0137"
/note="effector domain of the CAP family of transcription
factors; members include CAP (or cAMP receptor protein
(CRP)), which binds cAMP, FNR (fumarate and nitrate
reduction), which uses an iron-sulfur cluster to sense
oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
cd00038"
/db_xref="CDD:28920"
misc_feature order(153379..153384,153409..153417)
/locus_tag="BCG_0137"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:28920"
misc_feature order(153475..153483,153493..153501)
/locus_tag="BCG_0137"
/note="flexible hinge region; other site"
/db_xref="CDD:28920"
gene complement(153722..154006)
/gene="rpmB"
/locus_tag="BCG_0138c"
/db_xref="GeneID:4695457"
CDS complement(153722..154006)
/gene="rpmB"
/locus_tag="BCG_0138c"
/note="required for 70S ribosome assembly"
/codon_start=1
/transl_table=11
/product="50S ribosomal protein L28"
/protein_id="YP_976241.1"
/db_xref="GI:121636018"
/db_xref="GeneID:4695457"
/translation="MSARCQITGRTVGFGKAVSHSHRRTRRRWPPNIQLKAYYLPSED
RRIKVRVSAQGIKVIDRDGHRGRRRAARAGSAPAHFARQAGSSLRTAAIL"
misc_feature complement(<153824..154006)
/gene="rpmB"
/locus_tag="BCG_0138c"
/note="50S ribosomal protein L28; Reviewed; Region: rpmB;
PRK00359"
/db_xref="CDD:234736"
gene 154116..155312
/locus_tag="BCG_0139"
/db_xref="GeneID:4697629"
CDS 154116..155312
/locus_tag="BCG_0139"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976242.1"
/db_xref="GI:121636019"
/db_xref="GeneID:4697629"
/translation="MRTPVILVAGQDHTDEVTGALLRRTGTVVVEHRFDGHVVRRMTA
TLSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPWLEPQPI
CWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLGEDELPDGRTVAQVT
VGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGGVDRVELALAHLDDNSRRGRTDTP
HTPLLAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLWLANRPD
QVMWLESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVL
VCGADPTDIVNALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHR
NSGESR"
misc_feature 154122..155171
/locus_tag="BCG_0139"
/note="Putative GTPases (G3E family) [General function
prediction only]; Region: COG0523"
/db_xref="CDD:223597"
misc_feature 154827..155168
/locus_tag="BCG_0139"
/note="Cobalamin synthesis protein cobW C-terminal domain;
Region: CobW_C; smart00833"
/db_xref="CDD:214844"
gene complement(155407..160284)
/gene="ctpI"
/locus_tag="BCG_0140c"
/db_xref="GeneID:4696800"
CDS complement(155407..160284)
/gene="ctpI"
/locus_tag="BCG_0140c"
/EC_number="3.6.3.-"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a single base insertion (*-t) leads
to a product with a different COOH part compared to its
homolog in Mycobacterium tuberculosis strain H37Rv;
differs from Rv0107c by 3aa, V136A, P1247S, S1327A"
/codon_start=1
/transl_table=11
/product="cation-transporter atpase I ctpI"
/protein_id="YP_976243.1"
/db_xref="GI:121636020"
/db_xref="GeneID:4696800"
/translation="MKIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLE
LTGPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPFPRWHEH
AAMVEEPVRRIPGVAEAHVEGSLGRLVVELEPDVDSDIAVDEVRDVVSAVAADIFLAG
SVSSPNSAPFADPGNPLAILVPLTAAAMDLVAMGATVTGWVARLPAAPQTTRALAALI
NHQPRMVSLMESRLGRVGTDIALAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHR
RVWRDREPALASPRRPQAPVVPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAA
IDTAKGSRAGPVEQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQA
FAAVLGRGLANTGQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEPGWDDD
RVYEVADALLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQGLEHADLVVDGQCV
GSVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVGSTHPPGTPLLKLVRE
LRADRGPVLLITAVHRDFASTDTLAALAIADVGVALDDPRGATPWTADLITGTDLAAA
VRILSALPVARAASESAVHLAQGGTTLAGLLLVTGEQDKTTNPASFRRWLNPVNAAAA
TALVSGMWSAAKVLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRI
LDDLSYEPVMAPLRGPARTLAQLAVATRHELADPLTPILAVGAAASAIVGSNIDALLV
AGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTRRRLEAARHATRTA
TVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLEVDESFLTGESLPVDKQVDPVAVND
PDRASMLFEGSTIVAGHARAIVVATGVGTAAHRAISAVADVETAAGVQARLRELTSKV
LPMTLAGGAAVTALALLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTA
RGALVRSPRTIEALGRVDTICFDKTGTLTENRLRVVCALPSSTAAERDPLPQTTDAPS
AEVLRAAARASTQPHNGEGHAHATDEAILAAASALAGSLSSQGDSEWVVLAEVPFESS
RGYAAAIGRVGTDGIPMLMLKGAPETILPRCRLADPGVDHEHAESVVRHLAEQGLRVL
AVAQRTWDNGTTHDDETDADAVDAVAHDLELIGYVGLADTARPSSRPLIEALLDAERN
VVLITGDHPITARAIARQLGLPADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQ
KVQIVASLQRCGRVTAMVGDGANDAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDL
GVLLDALVEGRSMWAGVRDAVTILVGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNL
LTDMFPALAVAVTSQFAEPDDAEYPTDDAAERAQREHRRAVLIGPTPSLDAPLLRQIV
NRGVVTAAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLTRRHSPLVIATAL
GSAGVLVGIIQTPVISHFFGCTPLGPVAWTGVFSATAGATAVSALAPKWLASTVGVVQ
PDERPDDAEDSDAGG"
misc_feature complement(157156..>157716)
/gene="ctpI"
/locus_tag="BCG_0140c"
/note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122"
/db_xref="CDD:201018"
misc_feature complement(155947..157713)
/gene="ctpI"
/locus_tag="BCG_0140c"
/note="ATPase, P-type (transporting), HAD superfamily,
subfamily IC; Region: ATPase_P-type; TIGR01494"
/db_xref="CDD:213630"
misc_feature complement(156754..>156891)
/gene="ctpI"
/locus_tag="BCG_0140c"
/note="Putative hydrolase of sodium-potassium ATPase alpha
subunit; Region: Hydrolase_like2; pfam13246"
/db_xref="CDD:205426"
misc_feature complement(156232..156546)
/gene="ctpI"
/locus_tag="BCG_0140c"
/note="Haloacid dehalogenase-like hydrolases. The haloacid
dehalogenase-like (HAD) superfamily includes L-2-haloacid
dehalogenase, epoxide hydrolase, phosphoserine
phosphatase, phosphomannomutase, phosphoglycolate
phosphatase, P-type ATPase, and many others; Region:
HAD_like; cd01427"
/db_xref="CDD:119389"
misc_feature complement(156484..156486)
/gene="ctpI"
/locus_tag="BCG_0140c"
/note="motif II; other site"
/db_xref="CDD:119389"
misc_feature complement(155542..155997)
/gene="ctpI"
/locus_tag="BCG_0140c"
/note="Cation transporting ATPase, C-terminus; Region:
Cation_ATPase_C; pfam00689"
/db_xref="CDD:201396"
gene complement(160638..160847)
/locus_tag="BCG_0141c"
/db_xref="GeneID:4697539"
CDS complement(160638..160847)
/locus_tag="BCG_0141c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976244.1"
/db_xref="GI:121636021"
/db_xref="GeneID:4697539"
/translation="MVPVETLHSGDPITDVNGGGQRYIVLESKTVGDSCVVLELESRV
NHQLQVIEKSFPAGYHVGRAHHRIL"
gene 161126..162616
/gene="PE_PGRS1"
/locus_tag="BCG_0142"
/db_xref="GeneID:4698119"
CDS 161126..162616
/gene="PE_PGRS1"
/locus_tag="BCG_0142"
/note="Differs from Rv0109 by 1aa, G346R"
/codon_start=1
/transl_table=11
/product="PE-PGRS family protein"
/protein_id="YP_976245.1"
/db_xref="GI:121636022"
/db_xref="GeneID:4698119"
/translation="MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGA
DEVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQ
TVQQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQA
GGNGGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPG
GAGGNAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADG
GLGGGGGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGG
LAGIGGNAGFVGNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGN
GGMGGNAVGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAA
SAGGNGGNARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS"
misc_feature <161258..161407
/gene="PE_PGRS1"
/locus_tag="BCG_0142"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
gene 162764..163513
/locus_tag="BCG_0143"
/db_xref="GeneID:4696296"
CDS 162764..163513
/locus_tag="BCG_0143"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976246.1"
/db_xref="GI:121636023"
/db_xref="GeneID:4696296"
/translation="MRVGPVGHQCAECVREGARAVRQPRTPFGGRQRSATPVVTYTLI
SLNALVFVMQVTVMGLERQLALWPPAVASGQTYRLVTSAFLHYGAMHLLLNMWALYVV
GPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNTATAGASGAVFGLFGATFMVARR
LHLDVRWVVALIVINLAFTFLAPAISWQGHVGGLVTGALVAATYVYAPRERRNLIQAT
VTITVLVAFVVLIGWRTVDLLALFGGRLNLS"
misc_feature 162971..163390
/locus_tag="BCG_0143"
/note="Rhomboid family; Region: Rhomboid; pfam01694"
/db_xref="CDD:216649"
gene 163694..165751
/locus_tag="BCG_0144"
/db_xref="GeneID:4697514"
CDS 163694..165751
/locus_tag="BCG_0144"
/EC_number="2.3.1.-"
/codon_start=1
/transl_table=11
/product="acyltransferase"
/protein_id="YP_976247.1"
/db_xref="GI:121636024"
/db_xref="GeneID:4697514"
/translation="MPARSVPRPRWVAPVRRVGRLAVWDRPERRSGIPALDGLRAIAV
ALVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFWIRRARRL
LPALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFVAQNTDYFTQGAPPSP
LQHTWSLGVEEQYYVVWPLLLIGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMA
SATAAVAFTSAATRDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGR
RIARLLPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARI
LAWRPLVWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLI
EQPIRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAVAAVSP
SPPEASQPAPGPRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFRFIDHTVIGCSLVRGT
PYRYIGQTLEQRAECDGWPARWSAQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDP
TFDAYLNAELQRALSIVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAML
HNAISQHSNVGMIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVR
VAS"
misc_feature 163781..164884
/locus_tag="BCG_0144"
/note="Predicted acyltransferases [Lipid metabolism];
Region: COG1835"
/db_xref="CDD:32020"
misc_feature <164690..164872
/locus_tag="BCG_0144"
/note="Acyltransferase family; Region: Acyl_transf_3;
pfam01757"
/db_xref="CDD:201957"
misc_feature <165272..165727
/locus_tag="BCG_0144"
/note="SGNH_hydrolase, or GDSL_hydrolase, is a diverse
family of lipases and esterases. The tertiary fold of the
enzyme is substantially different from that of the
alpha/beta hydrolase family and unique among all known
hydrolases; its active site closely...; Region:
SGNH_hydrolase; cl01053"
/db_xref="CDD:207299"
misc_feature order(165359..165361,165674..165676,165683..165685)
/locus_tag="BCG_0144"
/note="active site"
/db_xref="CDD:58496"
misc_feature order(165674..165676,165683..165685)
/locus_tag="BCG_0144"
/note="catalytic triad [active]"
/db_xref="CDD:58496"
gene 166033..166989
/gene="gca"
/locus_tag="BCG_0145"
/db_xref="GeneID:4696313"
CDS 166033..166989
/gene="gca"
/locus_tag="BCG_0145"
/EC_number="4.2.1.47"
/codon_start=1
/transl_table=11
/product="GDP-mannose 4,6-dehydratase"
/protein_id="YP_976248.1"
/db_xref="GI:121636025"
/db_xref="GeneID:4696313"
/translation="MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFN
GAEVDITDWCSVYDSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEAL
RRVRPHAKIIVAGSSAEYGFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSY
GMHTVVARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRDL
NRALMLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEK
IIYGDCSKLAAITGWQQEICLTQTIADMFDYWRSKSESALMV"
misc_feature 166033..166974
/gene="gca"
/locus_tag="BCG_0145"
/note="Nucleoside-diphosphate-sugar epimerases [Cell
envelope biogenesis, outer membrane / Carbohydrate
transport and metabolism]; Region: WcaG; COG0451"
/db_xref="CDD:223528"
misc_feature 166036..166959
/gene="gca"
/locus_tag="BCG_0145"
/note="GDP-mannose 4,6 dehydratase, extended (e) SDRs;
Region: GDP_MD_SDR_e; cd05260"
/db_xref="CDD:187570"
misc_feature order(166051..166068,166126..166131,166174..166182,
166243..166251,166255..166257,166300..166302,
166372..166380,166456..166458,166468..166470,
166537..166551)
/gene="gca"
/locus_tag="BCG_0145"
/note="NADP-binding site; other site"
/db_xref="CDD:187570"
misc_feature order(166057..166062,166126..166131,166132..166137,
166171..166179,166183..166197,166201..166209,
166213..166215,166249..166260,166267..166269,
166273..166284,166294..166299,166309..166311,
166318..166323,166330..166332,166339..166344,
166435..166446,166450..166455,166462..166467,
166471..166476,166483..166488,166492..166500,
166504..166512,166567..166572,166846..166851)
/gene="gca"
/locus_tag="BCG_0145"
/note="homotetramer interface [polypeptide binding]; other
site"
/db_xref="CDD:187570"
misc_feature order(166255..166263,166378..166386,166456..166458,
166543..166545,166567..166575,166582..166584,
166636..166647,166654..166656,166660..166662,
166765..166767,166837..166839,166843..166845,
166852..166857)
/gene="gca"
/locus_tag="BCG_0145"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:187570"
misc_feature order(166273..166275,166282..166284,166294..166299,
166306..166311,166318..166323,166330..166332,
166435..166446,166450..166455,166462..166467,
166471..166476,166483..166488,166492..166500,
166504..166512,166846..166851)
/gene="gca"
/locus_tag="BCG_0145"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:187570"
misc_feature order(166303..166305,166378..166380,166456..166458,
166468..166470)
/gene="gca"
/locus_tag="BCG_0145"
/note="active site"
/db_xref="CDD:187570"
gene 167063..167653
/gene="gmhA"
/locus_tag="BCG_0146"
/db_xref="GeneID:4696528"
CDS 167063..167653
/gene="gmhA"
/locus_tag="BCG_0146"
/EC_number="5.-.-.-"
/note="catalyzes the isomerization of sedoheptulose
7-phosphate to D-glycero-D-manno-heptose 7-phosphate"
/codon_start=1
/transl_table=11
/product="phosphoheptose isomerase"
/protein_id="YP_976249.1"
/db_xref="GI:121636026"
/db_xref="GeneID:4696528"
/translation="MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRA
GARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTV
FARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADF
LINVPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ"
misc_feature 167093..167629
/gene="gmhA"
/locus_tag="BCG_0146"
/note="Phosphoheptose isomerase is a member of the SIS
(Sugar ISomerase) superfamily. Phosphoheptose isomerase
catalyzes the isomerization of sedoheptulose 7-phosphate
into D-glycero-D-mannoheptose 7-phosphate. This is the
first step of the biosynthesis of...; Region: SIS_GmhA;
cd05006"
/db_xref="CDD:240139"
misc_feature order(167102..167104,167114..167116,167156..167158,
167165..167167,167225..167227,167243..167248,
167579..167584,167594..167596,167603..167605,
167615..167617,167627..167629)
/gene="gmhA"
/locus_tag="BCG_0146"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:240139"
misc_feature order(167219..167227,167423..167431,167438..167440,
167567..167569,167579..167581)
/gene="gmhA"
/locus_tag="BCG_0146"
/note="active site"
/db_xref="CDD:240139"
gene 167685..168257
/locus_tag="BCG_0147"
/db_xref="GeneID:4697849"
CDS 167685..168257
/locus_tag="BCG_0147"
/EC_number="4.-.-.-"
/note="Differs from Rv0114 by 1aa, R121G"
/codon_start=1
/transl_table=11
/product="dehydratase"
/protein_id="YP_976250.1"
/db_xref="GI:121636027"
/db_xref="GeneID:4697849"
/translation="MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARA
LKKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHR
SQRCGCRKPRPGLVLDWLRRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIG
GASSGGVADASFDSLWEFAVAVGHARGERG"
misc_feature 167712..168113
/locus_tag="BCG_0147"
/note="histidinol-phosphate phosphatase family domain;
Region: Histidinol-ppas; TIGR01656"
/db_xref="CDD:162468"
misc_feature 167715..168110
/locus_tag="BCG_0147"
/note="Haloacid dehalogenase-like hydrolases. The haloacid
dehalogenase-like (HAD) superfamily includes L-2-haloacid
dehalogenase, epoxide hydrolase, phosphoserine
phosphatase, phosphomannomutase, phosphoglycolate
phosphatase, P-type ATPase, and many others; Region:
HAD_like; cd01427"
/db_xref="CDD:119389"
misc_feature order(167727..167735,167859..167864)
/locus_tag="BCG_0147"
/note="active site"
/db_xref="CDD:119389"
misc_feature 167727..167744
/locus_tag="BCG_0147"
/note="motif I; other site"
/db_xref="CDD:119389"
misc_feature 167859..167861
/locus_tag="BCG_0147"
/note="motif II; other site"
/db_xref="CDD:119389"
gene 168257..169324
/locus_tag="BCG_0149"
/db_xref="GeneID:4697418"
CDS 168257..169324
/locus_tag="BCG_0149"
/EC_number="2.-.-.-"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a single base insertion (*-c)
equivalent to Mycobacterium tuberculosis H37Rv position
139559, leads to shorter product with a different COOH
part compared to its homolog in Mycobacterium tuberculosis
strain H37Rv. In addition, in Mycobacterium bovis, a
single base insertion, at position equivalent to 138823,
leads to a different NH2 part"
/codon_start=1
/transl_table=11
/product="sugar kinase"
/protein_id="YP_976251.1"
/db_xref="GI:121636028"
/db_xref="GeneID:4697418"
/translation="MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAF
AERGTGDEIAFRSPDRDRAGQASIDDLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQL
ATQVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQ
DHYAAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQ
QRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNP
AIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFT
KGGAVTWHIPESTAPRKAWSC"
misc_feature 168311..169288
/locus_tag="BCG_0149"
/note="Predicted kinase related to galactokinase and
mevalonate kinase [General function prediction only];
Region: COG2605"
/db_xref="CDD:225325"
gene complement(170012..170767)
/locus_tag="BCG_0150c"
/db_xref="GeneID:4695709"
CDS complement(170012..170767)
/locus_tag="BCG_0150c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976252.1"
/db_xref="GI:121636029"
/db_xref="GeneID:4695709"
/translation="MRRVVRYLSVVVAITLMLTAESVSIATAAVPPLQPIPGVASVSP
ANGAVVGVAHPVVVTFTTPVTDRRAVERSIRISTPHNTTGHFEWVASNVVRWVPHRYW
PPHTRVSVGVQELTEGFETGDALIGVASISAHTFTVSRNGEVLRTMPASLGKPSRPTP
IGSFHAMSKERTVVMDSRTIGIPLNSSDGYLLTAHYAVRVTWSGVYVHSAPWSVNSQG
YANVSHGCINLSPDNAAWYFDAVTVGDPIEVVG"
misc_feature complement(170015..170725)
/locus_tag="BCG_0150c"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: ErfK; COG1376"
/db_xref="CDD:224294"
misc_feature complement(170396..170680)
/locus_tag="BCG_0150c"
/note="IgD-like repeat domain of mycobacterial
L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431"
/db_xref="CDD:240446"
misc_feature complement(170021..170386)
/locus_tag="BCG_0150c"
/note="L,D-transpeptidase catalytic domain; Region: YkuD;
pfam03734"
/db_xref="CDD:217702"
gene 170945..171889
/gene="oxyS"
/locus_tag="BCG_0151"
/db_xref="GeneID:4697654"
CDS 170945..171889
/gene="oxyS"
/locus_tag="BCG_0151"
/codon_start=1
/transl_table=11
/product="oxidative stress response regulatory protein
oxyS"
/protein_id="YP_976253.1"
/db_xref="GI:121636030"
/db_xref="GeneID:4697654"
/translation="MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELN
VTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTAS
TTASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVP
LYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQVIDAAFADHAVSAIP
QVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALA
TNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR"
misc_feature 170945..171817
/gene="oxyS"
/locus_tag="BCG_0151"
/note="Transcriptional regulator [Transcription]; Region:
LysR; COG0583"
/db_xref="CDD:223656"
misc_feature 170951..171130
/gene="oxyS"
/locus_tag="BCG_0151"
/note="Bacterial regulatory helix-turn-helix protein, lysR
family; Region: HTH_1; pfam00126"
/db_xref="CDD:215735"
misc_feature 171218..171826
/gene="oxyS"
/locus_tag="BCG_0151"
/note="The substrate binding domain of LysR-type
transcriptional regulators (LTTRs), a member of the type 2
periplasmic binding fold protein superfamily; Region:
PBP2_LTTR_substrate; cd05466"
/db_xref="CDD:176102"
misc_feature order(171260..171265,171269..171274,171281..171283,
171293..171295,171299..171313,171317..171322,
171599..171616,171632..171637,171641..171646)
/gene="oxyS"
/locus_tag="BCG_0151"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:176102"
gene complement(171873..173621)
/gene="oxcA"
/locus_tag="BCG_0152c"
/db_xref="GeneID:4695405"
CDS complement(171873..173621)
/gene="oxcA"
/locus_tag="BCG_0152c"
/EC_number="4.1.1.8"
/note="catalyzes the formation of formyl-CoA from
oxalyl-CoA"
/codon_start=1
/transl_table=11
/product="oxalyl-CoA decarboxylase"
/protein_id="YP_976254.1"
/db_xref="GI:121636031"
/db_xref="GeneID:4695405"
/translation="MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLAR
AAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCF
PMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTAT
SGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQR
PLLVLGKGAAYAQADNVIREFVEHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARA
DVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSA
LLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRN
PDVYVVNEGANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAI
EGDSAFGFSGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWRHDPAPTVL
NAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVESGHLA
KLNTTSAATPAISGDG"
misc_feature complement(171891..173588)
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="putative oxalyl-CoA decarboxylase; Validated;
Region: PRK09259"
/db_xref="CDD:236433"
misc_feature complement(173106..173573)
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="Pyrimidine (PYR) binding domain of POX and related
proteins; Region: TPP_PYR_POX_like; cd07035"
/db_xref="CDD:132918"
misc_feature complement(order(173322..173327,173334..173336,
173346..173348,173367..173369,173403..173411,
173415..173420,173427..173432,173439..173441,
173448..173468,173490..173492,173502..173504,
173514..173519,173532..173534))
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="PYR/PP interface [polypeptide binding]; other site"
/db_xref="CDD:132918"
misc_feature complement(order(173220..173222,173229..173231,
173337..173339,173346..173351,173355..173360,
173367..173369,173442..173444,173448..173459,
173463..173465,173490..173492,173502..173504,
173511..173519))
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:132918"
misc_feature complement(order(173355..173357,173367..173369,
173445..173447,173517..173519))
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="TPP binding site [chemical binding]; other site"
/db_xref="CDD:132918"
misc_feature complement(172617..173006)
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="Thiamine pyrophosphate enzyme, central domain;
Region: TPP_enzyme_M; pfam00205"
/db_xref="CDD:215786"
misc_feature complement(171957..172490)
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL
subfamily, TPP-binding module; composed of proteins
similar to benzaldehyde lyase (BZL), oxalyl-CoA
decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase
(2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region:
TPP_BZL_OCoD_HPCL; cd02004"
/db_xref="CDD:238962"
misc_feature complement(order(172170..172172,172176..172178,
172182..172184,172257..172268,172335..172337,
172341..172343,172410..172421,172488..172490))
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="TPP-binding site; other site"
/db_xref="CDD:238962"
misc_feature complement(order(172059..172064,172074..172076,
172080..172085,172092..172094,172104..172106,
172110..172112,172143..172145,172230..172232,
172239..172241,172248..172253,172263..172265,
172344..172346))
/gene="oxcA"
/locus_tag="BCG_0152c"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:238962"
gene 173794..175371
/gene="fadD7"
/locus_tag="BCG_0153"
/db_xref="GeneID:4695404"
CDS 173794..175371
/gene="fadD7"
/locus_tag="BCG_0153"
/EC_number="2.3.1.86"
/note="activates fatty acids by binding to coenzyme A"
/codon_start=1
/transl_table=11
/product="acyl-CoA synthetase"
/protein_id="YP_976255.1"
/db_xref="GI:121636032"
/db_xref="GeneID:4695404"
/translation="MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLV
DELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRS
QAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATS
TPEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLY
HGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERS
ATEPSGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMTEATHQVTTTQIEG
IDQTETPVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTIT
AANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEA
AVFGVPHQLYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTA
KGSLDRRAVAERFGHSV"
misc_feature 173794..175368
/gene="fadD7"
/locus_tag="BCG_0153"
/note="acyl-CoA synthetase; Validated; Region: PRK05852"
/db_xref="CDD:168271"
misc_feature 173854..>174420
/gene="fadD7"
/locus_tag="BCG_0153"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:213459"
misc_feature 174289..175350
/gene="fadD7"
/locus_tag="BCG_0153"
/note="Subfamily of fatty acid CoA ligase (FACL) similar
to Fum10p of Gibberella moniliformis; Region:
FACL_fum10p_like; cd05926"
/db_xref="CDD:213292"
misc_feature order(174307..174309,174316..174333,174337..174342)
/gene="fadD7"
/locus_tag="BCG_0153"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213292"
misc_feature order(174307..174309,174316..174333,174337..174342)
/gene="fadD7"
/locus_tag="BCG_0153"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213270"
misc_feature order(174316..174318,174673..174678,174739..174756,
175006..175008,175042..175044,175051..175053,
175084..175086,175324..175326)
/gene="fadD7"
/locus_tag="BCG_0153"
/note="putative AMP binding site [chemical binding]; other
site"
/db_xref="CDD:213292"
misc_feature order(174316..174318,174436..174441,174586..174588,
174592..174597,174604..174606,174673..174678,
174739..174756,175006..175008,175042..175044,
175051..175053,175075..175086,175267..175269)
/gene="fadD7"
/locus_tag="BCG_0153"
/note="putative active site [active]"
/db_xref="CDD:213292"
misc_feature order(174436..174438,174592..174597,174604..174606,
174673..174675,175075..175083,175249..175251,
175267..175269)
/gene="fadD7"
/locus_tag="BCG_0153"
/note="putative CoA binding site [chemical binding]; other
site"
/db_xref="CDD:213292"
gene complement(175372..177516)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/db_xref="GeneID:4696274"
CDS complement(175372..177516)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/standard_name="fus2"
/note="EF-G; promotes GTP-dependent translocation of the
ribosome during translation; many organisms have multiple
copies of this gene"
/codon_start=1
/transl_table=11
/product="elongation factor G"
/protein_id="YP_976256.1"
/db_xref="GI:121636033"
/db_xref="GeneID:4696274"
/translation="MADRVNASQGAAAAPTANGPGGVRNVVLVGPSGGGKTTLIEALL
VAAKVLSRPGSVTEGTTVCDFDEAEIRQQRSVGLAVASLAYDGIKVNLVDTPGYADFV
GELWAGLRAADCALFVIAANEGVDEPTKSLWQECSQVGMPRAVVITKLDHARANYREA
LTAAQDAFGDKVLPLYLPSGDGLIGLLSQALYEYADGKRTTRTPAESDTERIEEARGA
LIEGIIEESEDESLMERYLGGETIDESVLIQDLEKAVARGSFFPVIPVCSSTGVGTLE
LLEVATRGFPSPMEHPLPEVFTPQGVPHAELACDNDAPLLAEVVKTTSDPYVGRVSLV
RVFSGTIRPDTTVHVSGHFSSFFGGGTSNTHPDHDEDERIGVLSFPLGKQQRPAAAVV
AGDICAIGKLSRAETGDTLSDKAEPLVLKPWTMPEPLLPIAIAAHAKTDEDKLSVGLG
RLAAEDPTLRIEQNQETHQVVLWCMGEAHAGVVLDTLANRYGVSVDTIELRVPLRETF
AGNAKGHGRHIKQSGGHGQYGVCDIEVEPLPEGSGFEFLDKVVGGAVPRQFIPSVEKG
VRAQMDKGVHAGYPVVDIRVTLLDGKAHSVDSSDFAFQMAGALALREAAAATKVILLE
PIDEISVLVPDDFVGAVLGDLSSRRGRVLGTETAGHDRTVIKAEVPQVELTRYAIDLR
SLAHGAASFTRSFARYEPMPESAAARVKAGAG"
misc_feature complement(176653..177444)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="Elongation factor G (EF-G) family; Region:
EF-G_bact; cd04170"
/db_xref="CDD:206733"
misc_feature complement(175384..177432)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="elongation factor G; Reviewed; Region: PRK12740"
/db_xref="CDD:183713"
misc_feature complement(177406..177429)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="G1 box; other site"
/db_xref="CDD:206733"
misc_feature complement(order(177028..177030,177040..177042,
177148..177153,177220..177225,177277..177282,
177382..177387,177394..177396,177403..177408,
177418..177420,177424..177426))
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="putative GEF interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206733"
misc_feature complement(order(176710..176712,176716..176718,
177061..177066,177070..177072,177226..177228,
177292..177297,177403..177423))
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206733"
misc_feature complement(order(177280..177282,177286..177300))
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="Switch I region; other site"
/db_xref="CDD:206733"
misc_feature complement(177295..177297)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="G2 box; other site"
/db_xref="CDD:206733"
misc_feature complement(177226..177237)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="G3 box; other site"
/db_xref="CDD:206733"
misc_feature complement(177175..177231)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="Switch II region; other site"
/db_xref="CDD:206733"
misc_feature complement(177064..177075)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="G4 box; other site"
/db_xref="CDD:206733"
misc_feature complement(176710..176718)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="G5 box; other site"
/db_xref="CDD:206733"
misc_feature complement(176278..176574)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="EFG_mtEFG_II: this subfamily represents the domain
II of elongation factor G (EF-G) in bacteria and, the
C-terminus of mitochondrial Elongation factor G1 (mtEFG1)
and G2 (mtEFG2)_like proteins found in eukaryotes. During
the process of peptide synthesis...; Region: EFG_mtEFG_II;
cd04088"
/db_xref="CDD:58095"
misc_feature complement(175702..176004)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="EFG_mtEFG1_IV: domains similar to domain IV of the
bacterial translational elongation factor (EF) EF-G.
Included in this group is a domain of mitochondrial
Elongation factor G1 (mtEFG1) proteins homologous to
domain IV of EF-G. Eukaryotic cells harbor 2...; Region:
EFG_mtEFG1_IV; cd01434"
/db_xref="CDD:58274"
misc_feature complement(175411..175647)
/gene="fusA2b"
/locus_tag="BCG_0154c"
/gene_synonym="fusA"
/note="EFG_mtEFG_C: domains similar to the C-terminal
domain of the bacterial translational elongation factor
(EF) EF-G. Included in this group is the C-terminus of
mitochondrial Elongation factor G1 (mtEFG1) and G2
(mtEFG2) proteins. Eukaryotic cells harbor 2...; Region:
EFG_mtEFG_C; cd03713"
/db_xref="CDD:58065"
gene complement(177652..178086)
/locus_tag="BCG_0155c"
/db_xref="GeneID:4695507"
CDS complement(177652..178086)
/locus_tag="BCG_0155c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976257.1"
/db_xref="GI:121636034"
/db_xref="GeneID:4695507"
/translation="MGEFDPKLRFAQSPVARLATSTPDGTPHLVPVVFALGARRPAEA
TGADVIYTAVDAKRKTTQRLRRLANLEHNPRASVLVDSYADDWTQLWWVRADGVAAIH
RDGEVMRAAYRLLRAKYAQYQSVPLNGPVIAIAVQRWASWHA"
misc_feature complement(177658..178083)
/locus_tag="BCG_0155c"
/note="PPOX class probable F420-dependent enzyme, Rv0121
family; Region: Rv0121_F420; TIGR03668"
/db_xref="CDD:132707"
gene 178235..178603
/locus_tag="BCG_0156"
/db_xref="GeneID:4696264"
CDS 178235..178603
/locus_tag="BCG_0156"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976258.1"
/db_xref="GI:121636035"
/db_xref="GeneID:4696264"
/translation="MAGSVSAAAGIGWVGLNVTETNRDQCYRVERTTVDALTHPEYRV
HTRGVQRVRVTRNARKHRVSKHRIVAAMRHCGVPVIQEDGSLYYQGRDTSGRLTEVVA
VEADDGDLIITHAMPKEWKR"
gene 178600..178968
/locus_tag="BCG_0157"
/db_xref="GeneID:4695590"
CDS 178600..178968
/locus_tag="BCG_0157"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976259.1"
/db_xref="GI:121636036"
/db_xref="GeneID:4695590"
/translation="MTKKPRNPADYVIGDDVEVSDVDLKQEEVYVDGERLTDERVEQM
ASESLRLAREREANLIPGGKSLSGGSAHSPAVQVVVSKATHAKLKELARSRKMSVSKL
LRPVLDEFVQRETGRILPRR"
gene 179277..180893
/gene="PE_PGRS2"
/locus_tag="BCG_0158"
/db_xref="GeneID:4695953"
CDS 179277..180893
/gene="PE_PGRS2"
/locus_tag="BCG_0158"
/note="In Mycobacterium bovis and Mycobacterium bovis BCG
Pasteur, a 180 bp insertion leads to a longer product in
the 3' direction compared to its homolog in Mycobacterium
tuberculosis strain H37Rv (538 aa versus 487 aa)"
/codon_start=1
/transl_table=11
/product="PE-PGRS family protein"
/protein_id="YP_976260.1"
/db_xref="GI:121636037"
/db_xref="GeneID:4695953"
/translation="MSFVSVAPEIVVAAATDLAGIGSAISAANAAAAAPTTAVLAAGA
DEVSAAIAALFSGHAQAYQALSAQAAAFHQQFVQTLAGGAGAYAAAEAQVEQQLLAAI
NAPTQALLGRPLIGNGADGAPGTGQAGGAGGILYGNGGNGGSGAAGQAGGAGGPAGLI
GHGGSGGAGGHGGWLWGNGGVGGSGGAGVGAGVAGGHGGAGGAAGLWGAGGGGGNGGN
GADANIVSGGDGGLGGAGGGGGWLYGDGGAGGHGGQGAIGLGGGAGGDGGQGGAGRGL
WGTGGAGGHGGQGGGTGGPPLPGQAGMGAAGGAGGLIGNGGAGGDGGVGASGGVAGVG
GAGGNAMLIGHGGAGGAGGDSSFANGAAGGAGGAGGHLFGNGGSGGHGGAVTAGNTGI
GGAGGVGGDARLIGHGGAGGAGGDRAGALVGRDGGPGGNGGAGGQLYGNGGDGGPGGQ
GGQAFGANNIGGTGGAGGNGGPAILSGNGGNGGAGGAGGAGGAGGGAGGVGGAGGAPG
TGGTLQAAVSGLVTALFGAPGQPGDTGQPG"
misc_feature 179277..>179450
/gene="PE_PGRS2"
/locus_tag="BCG_0158"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
gene 181045..182112
/gene="pepA"
/locus_tag="BCG_0159"
/db_xref="GeneID:4697722"
CDS 181045..182112
/gene="pepA"
/locus_tag="BCG_0159"
/EC_number="3.4.21.-"
/codon_start=1
/transl_table=11
/product="serine protease pepA"
/protein_id="YP_976261.1"
/db_xref="GI:121636038"
/db_xref="GeneID:4697722"
/translation="MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFAD
FPALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATD
INAFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSG
GQGGTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQ
VVGMNTAASDNFQLSQGGQGFAIPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVD
NNGNGARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMADALNGHHPGDVISVT
WQTKSGGTRTGNVTLAEGPPA"
misc_feature 181189..182109
/gene="pepA"
/locus_tag="BCG_0159"
/note="Trypsin-like serine proteases, typically
periplasmic, contain C-terminal PDZ domain
[Posttranslational modification, protein turnover,
chaperones]; Region: DegQ; COG0265"
/db_xref="CDD:223343"
misc_feature 181279..181710
/gene="pepA"
/locus_tag="BCG_0159"
/note="Trypsin-like peptidase domain; Region: Trypsin_2;
pfam13365"
/db_xref="CDD:222077"
misc_feature <181888..182046
/gene="pepA"
/locus_tag="BCG_0159"
/note="PDZ domain of tryspin-like serine proteases, such
as DegP/HtrA, which are oligomeric proteins involved in
heat-shock response, chaperone function, and apoptosis.
May be responsible for substrate recognition and/or
binding, as most PDZ domains bind...; Region:
PDZ_serine_protease; cd00987"
/db_xref="CDD:238487"
gene 182221..184026
/gene="treS"
/locus_tag="BCG_0160"
/db_xref="GeneID:4696118"
CDS 182221..184026
/gene="treS"
/locus_tag="BCG_0160"
/EC_number="5.4.99.-"
/codon_start=1
/transl_table=11
/product="trehalose synthase treS"
/protein_id="YP_976262.1"
/db_xref="GI:121636039"
/db_xref="GeneID:4696118"
/translation="MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWF
KHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYD
IRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPY
GDYYVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQE
AMIDVIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRV
LLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTP
PIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDND
RNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTAN
PGRLYLPPSQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGG
SNPSVLAYVRQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIG
QVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL"
misc_feature 182347..183972
/gene="treS"
/locus_tag="BCG_0160"
/note="trehalose synthase; Region: treS_nterm; TIGR02456"
/db_xref="CDD:233874"
misc_feature 182347..183696
/gene="treS"
/locus_tag="BCG_0160"
/note="Alpha amylase catalytic domain found in Trehalose
synthetase; Region: AmyAc_TreS; cd11334"
/db_xref="CDD:200473"
misc_feature order(182926..182928,182932..182937,183058..183060,
183265..183270)
/gene="treS"
/locus_tag="BCG_0160"
/note="active site"
/db_xref="CDD:200473"
misc_feature order(182932..182934,183058..183060,183268..183270)
/gene="treS"
/locus_tag="BCG_0160"
/note="catalytic site [active]"
/db_xref="CDD:200473"
gene 184129..185496
/locus_tag="BCG_0161"
/db_xref="GeneID:4696821"
CDS 184129..185496
/locus_tag="BCG_0161"
/note="Differs from Rv0127 by 1aa, P18S"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976263.1"
/db_xref="GI:121636040"
/db_xref="GeneID:4696821"
/translation="MTRSDTLATKLPWSDWLPRQRWYAGRNRELATVKPGVVVALRHN
LDLVLVDVTYTDGATERYQVLVGWDFEPASEYGTKAAIGVADDRTGFDALYDVAGPQF
LLSLIVSSAVCGTSTGEVTFTREPDVELPFAAQPRVCDAEQSNTSVIFDRRAILKVFR
RVSSGINPDIELNRVLTRAGNPHVARLLGAYQFGRPNRSPTDALAYALGMVTEYEANA
AEGWAMATASVRDLFAEGDLYAHEVGGDFAGESYRLGEAVASVHATLADSLGTAQATF
PVDRMLARLSSTVAVVPELREYAPTIEQQFQKLAAEAITVQRVHGDLHLGQVLRTPES
WLLIDFEGEPGQPLDERRAPDSPLRDVAGVLRSFEYAAYGPLVDQATDKQLAARAREW
VERNRAAFCDGYAVASGIDPRDSALLLGAYELDKAVYETGYETRHRPGWLPIPLRSIA
RLTAS"
misc_feature 184132..185484
/locus_tag="BCG_0161"
/note="trehalose synthase-fused probable maltokinase;
Region: TreS_Cterm; TIGR02457"
/db_xref="CDD:233875"
misc_feature 184204..185493
/locus_tag="BCG_0161"
/note="Uncharacterized protein, probably involved in
trehalose biosynthesis [Carbohydrate transport and
metabolism]; Region: Ble; COG3281"
/db_xref="CDD:225820"
gene 185564..186343
/locus_tag="BCG_0162"
/db_xref="GeneID:4697426"
CDS 185564..186343
/locus_tag="BCG_0162"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976264.1"
/db_xref="GI:121636041"
/db_xref="GeneID:4697426"
/translation="MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQ
RAVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAA
GVDIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIE
RHLAGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLH
ADRRGLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS"
misc_feature 185564..186217
/locus_tag="BCG_0162"
/note="Predicted membrane protein [Function unknown];
Region: COG3619"
/db_xref="CDD:226146"
gene complement(186475..187497)
/gene="fbpC"
/locus_tag="BCG_0163c"
/db_xref="GeneID:4697184"
CDS complement(186475..187497)
/gene="fbpC"
/locus_tag="BCG_0163c"
/standard_name="mpt45; 85C; fbpC2"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976265.1"
/db_xref="GI:121636042"
/db_xref="GeneID:4697184"
/translation="MTFFEQVRRLRSAATTLPRRLAIAAMGAVLVYGLVGTFGGPATA
GAFSRPGLPVEYLQVPSASMGRDIKVQFQGGGPHAVYLLDGLRAQDDYNGWDINTPAF
EEYYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFLTREMPAWLQANKGVS
PTGNAAVGLSMSGGSALILAAYYPQQFPYAASLSGFLNPSEGWWPTLIGLAMNDSGGY
NANSMWGPSSDPAWKRNDPMVQIPRLVANNTRIWVYCGNGTPSDLGGDNIPAKFLEGL
TLRTNQTFRDTYAADGGRNGVFNFPPNGTHSWPYWNEQLVAMKADIQHVLNGATPPAA
PAAPAA"
misc_feature complement(186514..187476)
/gene="fbpC"
/locus_tag="BCG_0163c"
/note="Predicted esterase [General function prediction
only]; Region: COG0627"
/db_xref="CDD:223700"
gene 187744..188199
/locus_tag="BCG_0164"
/db_xref="GeneID:4696522"
CDS 187744..188199
/locus_tag="BCG_0164"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976266.1"
/db_xref="GI:121636043"
/db_xref="GeneID:4696522"
/translation="MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWI
HVDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPV
GSRVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA"
misc_feature 187750..188196
/locus_tag="BCG_0164"
/note="NodN (nodulation factor N) contains a single hot
dog fold similar to those of the peroxisomal
Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the
fatty acid synthase beta subunit. Rhizobium and related
species form nodules on the roots of their...; Region:
NodN; cd03450"
/db_xref="CDD:239534"
misc_feature order(187846..187848,187861..187863,187867..187869,
187876..187878,187921..187923,187930..187935)
/locus_tag="BCG_0164"
/note="putative active site [active]"
/db_xref="CDD:239534"
misc_feature order(187861..187863,187867..187869,187876..187878,
187930..187932)
/locus_tag="BCG_0164"
/note="putative catalytic site [active]"
/db_xref="CDD:239534"
gene complement(188212..189555)
/gene="fadE1"
/locus_tag="BCG_0165c"
/db_xref="GeneID:4695959"
CDS complement(188212..189555)
/gene="fadE1"
/locus_tag="BCG_0165c"
/EC_number="1.3.99.-"
/codon_start=1
/transl_table=11
/product="acyl-CoA dehydrogenase fadE1"
/protein_id="YP_976267.1"
/db_xref="GI:121636044"
/db_xref="GeneID:4695959"
/translation="MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLV
ALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSR
WAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLF
VTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTP
GIEIVRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHA
MRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWL
IDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLG
IADGATELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF"
misc_feature complement(188311..189510)
/gene="fadE1"
/locus_tag="BCG_0165c"
/note="Acyl-CoA dehydrogenases [Lipid metabolism]; Region:
CaiA; COG1960"
/db_xref="CDD:224871"
misc_feature complement(188323..189486)
/gene="fadE1"
/locus_tag="BCG_0165c"
/note="Acyl-CoA dehydrogenase; Region: ACAD; cl09933"
/db_xref="CDD:245208"
misc_feature complement(order(188359..188361,188365..188367,
188371..188379,189004..189006,189010..189012,
189112..189114,189118..189120,189208..189210))
/gene="fadE1"
/locus_tag="BCG_0165c"
/note="active site"
/db_xref="CDD:173838"
gene complement(189597..190679)
/gene="fgd2"
/locus_tag="BCG_0166c"
/db_xref="GeneID:4695872"
CDS complement(189597..190679)
/gene="fgd2"
/locus_tag="BCG_0166c"
/EC_number="1.-.-.-"
/note="Differs from Rv0132c by 1aa, E147K"
/codon_start=1
/transl_table=11
/product="F420-dependent glucose-6-phosphate
dehydrogenase"
/protein_id="YP_976268.1"
/db_xref="GI:121636045"
/db_xref="GeneID:4695872"
/translation="MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGV
GVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNS
TSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGN
YRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSA
TLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAAR
AADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAV
PFLHFPQDDPITAIDFYRTNVLPELR"
misc_feature complement(189600..190550)
/gene="fgd2"
/locus_tag="BCG_0166c"
/note="F420-dependent oxidoreductase, G6PDH family;
Region: F420_G6P_family; TIGR03557"
/db_xref="CDD:234255"
misc_feature complement(<189984..190301)
/gene="fgd2"
/locus_tag="BCG_0166c"
/note="N5,N10-methylenetetrahydromethanopterin reductase
(Mer) catalyzes the reduction of
N5,N10-methylenetetrahydromethanopterin with reduced
coenzyme F420 to N5-methyltetrahydromethanopterin and
oxidized coenzyme F420; Region:
Tetrahydromethanopterin_reductase; cd01097"
/db_xref="CDD:238530"
gene 190766..191248
/locus_tag="BCG_0167"
/db_xref="GeneID:4695794"
CDS 190766..191248
/locus_tag="BCG_0167"
/EC_number="2.3.1.-"
/note="In Mycobacterium tuberculosis strain H37Rv, and
Mycobacterium bovis AF2122/97, codon 161 is TAC and in
Mycobacterium bovis BCG Pasteur, TAA"
/codon_start=1
/transl_table=11
/product="acetyltransferase"
/protein_id="YP_976269.1"
/db_xref="GI:121636046"
/db_xref="GeneID:4695794"
/translation="MTPQARPARRADVRELSRTMARAFYDDPFMSWLLSNDNARTARL
TRLFATIVRHQHLAGGGVEVARGAAGIGGAALWDPPDRWRESRRQQLAMTPGFLRVFG
FRTAKARAALDVMMRVHPEEPHWYLAAIGSDPTVRGQGFGQVLMRSRLDRCDAEHCPA
"
misc_feature <191108..>191239
/locus_tag="BCG_0167"
/note="Acetyltransferase (GNAT) domain; Region:
Acetyltransf_7; pfam13508"
/db_xref="CDD:205686"
misc_feature order(191153..191161,191189..191194)
/locus_tag="BCG_0167"
/note="Coenzyme A binding pocket [chemical binding]; other
site"
/db_xref="CDD:173926"
gene 191668..192051
/locus_tag="BCG_0168"
/pseudo
/db_xref="GeneID:4698881"
misc_feature 191668..192051
/locus_tag="BCG_0168"
/pseudo
gene 192051..192158
/locus_tag="BCG_0169"
/pseudo
/db_xref="GeneID:4696383"
misc_feature 192051..192158
/locus_tag="BCG_0169"
/pseudo
gene 192160..192570
/locus_tag="BCG_0170"
/pseudo
/db_xref="GeneID:4695611"
misc_feature 192160..192570
/locus_tag="BCG_0170"
/note="differs from Mb0139-3 by 1aa, G16R"
/pseudo
gene complement(192541..193146)
/locus_tag="BCG_0171c"
/db_xref="GeneID:4696778"
CDS complement(192541..193146)
/locus_tag="BCG_0171c"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976270.1"
/db_xref="GI:121636047"
/db_xref="GeneID:4696778"
/translation="MTAVAAGALVVETDSFRLRLLDGLVASIGERGYRATTVSDIVRH
ARTSKRTFYDRFTSKEQCFLELLLADNETLGNSIRAAVDPNADWHDQIRQAVEAYVTH
IESRPAVTLSWIREFPSLGAAAYPVQRRGMEQLTSLLIELSASPGFRRANLPPLNVPL
AVILLGGLRELTALTVEDGQPIRNIVEPAVDASIALLGPRS"
misc_feature complement(192544..193113)
/locus_tag="BCG_0171c"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature complement(192949..193089)
/locus_tag="BCG_0171c"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 193263..194588
/gene="cyp138"
/locus_tag="BCG_0172"
/db_xref="GeneID:4696345"
CDS 193263..194588
/gene="cyp138"
/locus_tag="BCG_0172"
/EC_number="1.14.-.-"
/codon_start=1
/transl_table=11
/product="cytochrome p450 138 cyp138"
/protein_id="YP_976271.1"
/db_xref="GI:121636048"
/db_xref="GeneID:4696345"
/translation="MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVR
RYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGD
DHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILR
AIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVID
KLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLG
WAFERLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGE
WVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAA
FANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR"
misc_feature 193398..194585
/gene="cyp138"
/locus_tag="BCG_0172"
/note="Cytochrome P450 [Secondary metabolites
biosynthesis, transport, and catabolism]; Region: CypX;
COG2124"
/db_xref="CDD:225035"
misc_feature 193398..194501
/gene="cyp138"
/locus_tag="BCG_0172"
/note="Cytochrome P450; Region: p450; cl12078"
/db_xref="CDD:245864"
gene complement(194609..195157)
/gene="msrA"
/locus_tag="BCG_0173c"
/db_xref="GeneID:4696607"
CDS complement(194609..195157)
/gene="msrA"
/locus_tag="BCG_0173c"
/EC_number="1.8.4.11"
/note="this stereospecific enzymes reduces the S isomer of
methionine sulfoxide while MsrB reduces the R form;
provides protection against oxidative stress"
/codon_start=1
/transl_table=11
/product="methionine sulfoxide reductase A"
/protein_id="YP_976272.1"
/db_xref="GI:121636049"
/db_xref="GeneID:4696607"
/translation="MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATY
RNHGTHAEAVEIIFDPTVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQ
QKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPG
WRLPRRTAESALRASLSPELGT"
misc_feature complement(194660..195154)
/gene="msrA"
/locus_tag="BCG_0173c"
/note="methionine sulfoxide reductase A; Provisional;
Region: PRK14054"
/db_xref="CDD:237597"
gene 195220..195723
/locus_tag="BCG_0174"
/db_xref="GeneID:4697736"
CDS 195220..195723
/locus_tag="BCG_0174"
/note="Differs from Mb0143 by 1aa, D96G"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976273.1"
/db_xref="GI:121636050"
/db_xref="GeneID:4697736"
/translation="MSASEFSRAELAAAFEKFEKTVARAAATRDWDCWVQHYTPDVEY
IEHAAGIMRGRQRVRAWIQETMTTFPGSHMVAFPSLWSVIDESTGRIICELDNPMLDP
GDGSVISATNISIITYAGNGQWCRQEDIYNPLRFLRAAMKWCRKAQELGTLDEDAARW
MRRHGGP"
misc_feature 195289..195597
/locus_tag="BCG_0174"
/note="SnoaL-like domain; Region: SnoaL_2; pfam12680"
/db_xref="CDD:221707"
gene 195724..196746
/locus_tag="BCG_0175"
/db_xref="GeneID:4697886"
CDS 195724..196746
/locus_tag="BCG_0175"
/EC_number="1.-.-.-"
/note="Differs from Rv0139 by 1aa, R227H"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976274.1"
/db_xref="GI:121636051"
/db_xref="GeneID:4697886"
/translation="MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTR
SIDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNV
LDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYA
HDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAVGVDDAARA
LILAAERGRNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLR
ARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVG
KDPAAS"
misc_feature 195733..196710
/locus_tag="BCG_0175"
/note="hopanoid-associated sugar epimerase; Region: HpnA;
TIGR03466"
/db_xref="CDD:163279"
misc_feature 195739..196698
/locus_tag="BCG_0175"
/note="Rossmann-fold NAD(P)(+)-binding proteins; Region:
NADB_Rossmann; cl09931"
/db_xref="CDD:245206"
misc_feature order(195748..195750,195754..195759,195763..195765,
195832..195840,195952..195960,196072..196080,
196156..196158,196168..196170,196237..196248)
/locus_tag="BCG_0175"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:187535"
misc_feature order(196006..196008,196078..196080,196156..196158,
196168..196170)
/locus_tag="BCG_0175"
/note="active site"
/db_xref="CDD:187535"
gene 196807..197187
/locus_tag="BCG_0176"
/db_xref="GeneID:4696471"
CDS 196807..197187
/locus_tag="BCG_0176"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976275.1"
/db_xref="GI:121636052"
/db_xref="GeneID:4696471"
/translation="MSNRIVLEPSADHPITIEPTNRRVQVRVNGEVVADTAAALCLQE
ASYPAVQYIPLADVVQDRLIRTETSTYCPFKGEASYYSVTTDAGDIVDDVMWTYENPY
PAVAAIAGHVACYPDKAEISIFPG"
misc_feature 196807..197184
/locus_tag="BCG_0176"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG2343"
/db_xref="CDD:225220"
gene complement(197168..197578)
/locus_tag="BCG_0177c"
/db_xref="GeneID:4697244"
CDS complement(197168..197578)
/locus_tag="BCG_0177c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976276.1"
/db_xref="GI:121636053"
/db_xref="GeneID:4697244"
/translation="MTPFDDPQAELAWMFLQSLCEGGDLDEGFALLSNDFTYWSIVTR
TELDKKTFRRAVERRKQVFEVNIELIRCVNEGETVVVEGHCDGVSADRTRYDSPFVCI
FETRDGMIISLREYSDTQSLAEVYPVACATPGRC"
misc_feature complement(197171..197566)
/locus_tag="BCG_0177c"
/note="Ketosteroid isomerase-related protein [General
function prediction only]; Region: COG3631"
/db_xref="CDD:226158"
gene 197608..198534
/locus_tag="BCG_0178"
/db_xref="GeneID:4695477"
CDS 197608..198534
/locus_tag="BCG_0178"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976277.1"
/db_xref="GI:121636054"
/db_xref="GeneID:4695477"
/translation="MRSIDVVVEAVVTFAGAAGFAHTLAPLRRGQQDPCFRVPGDGTI
WRTSLLPTGPVTARISRAGRDAARCVAWGSGAEEFVDMAPAMLGAADDASDFVPLHPA
VAAAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQAPGPAPP
GMRVPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLERLVSLPAARAAEALT
SLPGVGVWTAAETTQRVFGDADAVSVGDYHIPKMIGWTLVGRPVDDAGMLELLEPMRP
HRHRVVRLLEASGLAREPRRGPRLPVQNIRAL"
misc_feature 197671..198510
/locus_tag="BCG_0178"
/note="3-methyladenine DNA glycosylase/8-oxoguanine DNA
glycosylase [DNA replication, recombination, and repair];
Region: AlkA; COG0122"
/db_xref="CDD:223200"
misc_feature 197974..198453
/locus_tag="BCG_0178"
/note="endonuclease III; includes endonuclease III
(DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA
glycosidases (Alka-family) and other DNA glycosidases;
Region: ENDO3c; cd00056"
/db_xref="CDD:238013"
misc_feature order(198004..198012,198019..198021,198169..198171)
/locus_tag="BCG_0178"
/note="minor groove reading motif; other site"
/db_xref="CDD:238013"
misc_feature 198265..198288
/locus_tag="BCG_0178"
/note="helix-hairpin-helix signature motif; other site"
/db_xref="CDD:238013"
misc_feature 198343..198345
/locus_tag="BCG_0178"
/note="active site"
/db_xref="CDD:238013"
gene complement(198601..200079)
/locus_tag="BCG_0179c"
/db_xref="GeneID:4696266"
CDS complement(198601..200079)
/locus_tag="BCG_0179c"
/note="Differs from Rv0143c by 1aa, L34F"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976278.1"
/db_xref="GI:121636055"
/db_xref="GeneID:4696266"
/translation="MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRLGVSIRSAGYL
RKWFLLGITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGFAR
PWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGRAVLVKMVASA
LTIGSGGSGGREGPTAQISAGFCSLLTRRLNLSNEDGRTAVALGIGAGIGAIFAAPLG
GAALGASIPYRDDFDYRNLLPGFIASGTAYAVLGAFLGFDPLFGYIDAEYRFEKAWPL
LWFVVIGLIAAAVGYLYARVFHASVAITRRLPGGPVLKPAIGGLLVGLLGLPIPQILS
SGYGWAQLAADRGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVG
AAIWRLGELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVPGA
IIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA"
misc_feature complement(198613..199953)
/locus_tag="BCG_0179c"
/note="Chloride channel protein EriC [Inorganic ion
transport and metabolism]; Region: EriC; COG0038"
/db_xref="CDD:223116"
misc_feature complement(198745..199917)
/locus_tag="BCG_0179c"
/note="CLC voltage-gated chloride channel. The ClC
chloride channels catalyse the selective flow of Cl- ions
across cell membranes, thereby regulating electrical
excitation in skeletal muscle and the flow of salt and
water across epithelial barriers. This...; Region:
Voltage_gated_ClC; cd00400"
/db_xref="CDD:238233"
misc_feature complement(order(198931..198945,199558..199572,
199663..199677))
/locus_tag="BCG_0179c"
/note="Cl- selectivity filter; other site"
/db_xref="CDD:238233"
misc_feature complement(order(198937..198945,199561..199566,
199666..199668,199672..199674))
/locus_tag="BCG_0179c"
/note="Cl- binding residues [ion binding]; other site"
/db_xref="CDD:238233"
misc_feature complement(199564..199566)
/locus_tag="BCG_0179c"
/note="pore gating glutamate residue; other site"
/db_xref="CDD:238233"
misc_feature complement(order(198763..198765,198787..198789,
198796..198798,199333..199335,199354..199356,
199402..199404,199429..199431))
/locus_tag="BCG_0179c"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:238233"
gene 200181..201023
/locus_tag="BCG_0180"
/db_xref="GeneID:4697048"
CDS 200181..201023
/locus_tag="BCG_0180"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976279.1"
/db_xref="GI:121636056"
/db_xref="GeneID:4697048"
/translation="MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGA
KLTSSVASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQVFS
ERGYDGATFQEIAVRADLTRPAINHYFANKRVLYQEVVEQTHELVIVAGIERARREPT
LMGRLAVVVDFAMEADAQYPASTAFLATTVLESQRHPELSRTENDAVRATREFLVWAV
NDAIERGELAADVDVSSLAETLLVVLCGVGFYIGFVGSYQRMATITDSFQQLLAGTLW
RPPT"
misc_feature 200418..200957
/locus_tag="BCG_0180"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature 200457..200597
/locus_tag="BCG_0180"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 201112..202065
/locus_tag="BCG_0181"
/db_xref="GeneID:4696148"
CDS 201112..202065
/locus_tag="BCG_0181"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976280.1"
/db_xref="GI:121636057"
/db_xref="GeneID:4696148"
/translation="MTELDDVSSLPSSRRTAGDTWAITESVGATALGVAAARAVETAA
TNPLIRDEFAKVLVSSAGTAWARLADADLAWLDGDQLGRRVHRVACDYQAVRTHFFDE
YFGAAVDAGVRQVVILAAGLDARAYRLNWPAGTVVYEIDQPSVLEYKAGILQSHGAVP
TARRHAVAVDLRDDWPAALIAAGFDGTQPTAWLAEGLLPYLPGDAADRLFDMVTALSA
PGSQVAVEAFTMNTKGNTQRWNRMRERLGLDIDVQALTYHEPDRSDAAQWLATHGWQV
HSVSNREEMARLGRAIPQDLVDETVRTTLLRGRLVTPAQPA"
misc_feature 201151..202047
/locus_tag="BCG_0181"
/note="O-Methyltransferase involved in polyketide
biosynthesis [Secondary metabolites biosynthesis,
transport, and catabolism]; Region: COG3315"
/db_xref="CDD:225852"
misc_feature 201247..201984
/locus_tag="BCG_0181"
/note="methyltransferase, TIGR00027 family; Region:
mthyl_TIGR00027"
/db_xref="CDD:232789"
gene 202108..203040
/locus_tag="BCG_0182"
/db_xref="GeneID:4695365"
CDS 202108..203040
/locus_tag="BCG_0182"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976281.1"
/db_xref="GI:121636058"
/db_xref="GeneID:4695365"
/translation="MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLL
VTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAG
IRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPA
DLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAET
APVHGEERRAEMRARFKKVADVLGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQ
RAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL"
misc_feature 202108..203013
/locus_tag="BCG_0182"
/note="O-Methyltransferase involved in polyketide
biosynthesis [Secondary metabolites biosynthesis,
transport, and catabolism]; Region: COG3315"
/db_xref="CDD:225852"
misc_feature 202189..202971
/locus_tag="BCG_0182"
/note="methyltransferase, TIGR00027 family; Region:
mthyl_TIGR00027"
/db_xref="CDD:232789"
gene 203135..204655
/locus_tag="BCG_0183"
/db_xref="GeneID:4695675"
CDS 203135..204655
/locus_tag="BCG_0183"
/EC_number="1.2.1.-"
/codon_start=1
/transl_table=11
/product="aldehyde dehydrogenase"
/protein_id="YP_976282.1"
/db_xref="GI:121636059"
/db_xref="GeneID:4695675"
/translation="MSDRVKAVAPPDGRTMMTTESVARKTQKSETEAPREPAPVSDEK
QTDVAKTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLDRNPFE
AYLADIATTSAEAKYAAKRVRRWMRRRYLLLEVPQLPGRGWVEYEPYGTVLIIGAWNY
PFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTELVYRYLDTEAIAVVQGDGAVSQ
ELIAQGFDRVMFTGGTEIGRKVYEGAAPHLTPVTLELGGKSPVIVAADADVDVAAKRI
AWIKLLNAGQTCVAPDYVLADATVRDELVSKITAALTKFRSGAPQGMRIVNQRQFDRL
SGYLAAAKTDAAADGGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVV
TVKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQVSTAKLP
FGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPPYTERAIKVARRLF"
misc_feature 203273..204652
/locus_tag="BCG_0183"
/note="aldehyde dehydrogenase family protein; Provisional;
Region: PTZ00381"
/db_xref="CDD:240392"
misc_feature 203285..204571
/locus_tag="BCG_0183"
/note="ALDH subfamily: Coniferyl aldehyde dehydrogenase,
ALDH families 3, 13, and 14, and other related proteins;
Region: ALDH_F3-13-14_CALDH-like; cd07087"
/db_xref="CDD:143406"
misc_feature order(203603..203611,203687..203689,203774..203776,
203828..203830,204113..204115,204119..204124,
204131..204133,204281..204283,204287..204289)
/locus_tag="BCG_0183"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:143406"
misc_feature order(203609..203611,203894..203896,203987..203989,
203996..203998)
/locus_tag="BCG_0183"
/note="catalytic residues [active]"
/db_xref="CDD:143406"
gene 204730..205590
/locus_tag="BCG_0184"
/db_xref="GeneID:4697099"
CDS 204730..205590
/locus_tag="BCG_0184"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="short-chain type dehydrogenase/reductase"
/protein_id="YP_976283.1"
/db_xref="GI:121636060"
/db_xref="GeneID:4697099"
/translation="MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDG
TGAGSAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGI
LRDGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFG
QTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFV
APVVAYLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDL
SGAKIAGFKL"
misc_feature 204730..205464
/locus_tag="BCG_0184"
/note="short chain dehydrogenase; Provisional; Region:
PRK07791"
/db_xref="CDD:236099"
misc_feature 204739..205455
/locus_tag="BCG_0184"
/note="(3R)-hydroxyacyl-CoA dehydrogenase-like,
classical(c)-like SDRs; Region:
hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353"
/db_xref="CDD:187611"
misc_feature order(204766..204768,204775..204783,204835..204843,
204847..204849,204943..204948,205024..205035,
205093..205098,205174..205182,205219..205221,
205231..205233,205309..205317,205321..205332)
/locus_tag="BCG_0184"
/note="NAD binding site [chemical binding]; other site"
/db_xref="CDD:187611"
misc_feature order(204814..204816,205048..205056,205060..205068,
205075..205080,205087..205089,205099..205104,
205111..205113,205120..205125,205132..205137,
205183..205209,205213..205215,205222..205227,
205234..205239,205243..205251,205255..205263,
205267..205272,205276..205281,205285..205287,
205354..205356,205363..205368,205378..205380,
205387..205392,205396..205404,205423..205425,
205435..205443,205447..205455)
/locus_tag="BCG_0184"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:187611"
misc_feature order(205096..205098,205180..205182,205219..205221,
205231..205233)
/locus_tag="BCG_0184"
/note="active site"
/db_xref="CDD:187611"
gene 205597..206565
/locus_tag="BCG_0185"
/db_xref="GeneID:4698796"
CDS 205597..206565
/locus_tag="BCG_0185"
/EC_number="1.6.5.-"
/codon_start=1
/transl_table=11
/product="quinone oxidoreductase"
/protein_id="YP_976284.1"
/db_xref="GI:121636061"
/db_xref="GeneID:4698796"
/translation="MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDL
LLTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVA
NVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAK
AMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGP
TFDDALGVLAIDGKLLLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAAL
FAWGLNQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP"
misc_feature 205597..206562
/locus_tag="BCG_0185"
/note="NADPH:quinone reductase and related Zn-dependent
oxidoreductases [Energy production and conversion /
General function prediction only]; Region: Qor; COG0604"
/db_xref="CDD:223677"
misc_feature 205597..206559
/locus_tag="BCG_0185"
/note="Quinone oxidoreductase (QOR); Region: QOR1;
cd08241"
/db_xref="CDD:176203"
misc_feature order(205714..205719,205957..205959,205969..205971,
206032..206034,206041..206049,206107..206112,
206122..206124,206167..206169,206236..206238,
206302..206307,206311..206316,206377..206385,
206530..206532,206536..206538,206542..206544)
/locus_tag="BCG_0185"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:176203"
gene complement(206562..206849)
/locus_tag="BCG_0186c"
/db_xref="GeneID:4697427"
CDS complement(206562..206849)
/locus_tag="BCG_0186c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976285.1"
/db_xref="GI:121636062"
/db_xref="GeneID:4697427"
/translation="MLTLPDDRAPTGLPDPGIEALAHTKIASTISTVVADGYAVVLST
ADIANSLLANAIGYPIAASVALVTPAAGANSSCWPADPSQHHRIAESRACA"
gene complement(207440..209206)
/gene="PE1"
/locus_tag="BCG_0187c"
/db_xref="GeneID:4697778"
CDS complement(207440..209206)
/gene="PE1"
/locus_tag="BCG_0187c"
/note="Differs from Rv0151c by 1aa, R26G"
/codon_start=1
/transl_table=11
/product="PE family protein"
/protein_id="YP_976286.1"
/db_xref="GI:121636063"
/db_xref="GeneID:4697778"
/translation="MAPFGFTPKARHNRGVALRSTYRLDRWVMGPVDKEGWGLSYVFA
QPSVLAAAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQFQA
ISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEATAGLFKPTSPPVLPPMFNQN
TAIIMGGTGSPIPTPSYVNAITTLFIDPVVSNPVVKALVTPEELYPITGVKSLPFQTS
VQLGLQILDGAIWEQINAGNHVTVFGYSQSAVIASLEMQHLISLGPNAPSPSQLNFIL
IGNEMNPNGGILARIPGLNVTTLGLPFYGATPDNPYPTTTYTLEYDGFADFPRYPLNV
LSDINAVFGILTVHTTYADLTPAQIASATQLPTQGTTSNTYYIIETEHLPLLAPLRAI
PVIGPPLAALVEPNLEVIVNLGYGDPRFGYSTSPANVPTPFGLFPDVPASVVADALVA
GTQQGVNDFMVELPAALNTLPQTPMPAFPPYVPTLLPPPPPPQPATLINIADTFASVV
STGYSILLPTADLGLAFVTILPAYDLTLFVNQLAAGNLRAAIELPLAATIGLAALGGM
IEFIAIVVTLADITQQLQSFSI"
misc_feature complement(208853..209089)
/gene="PE1"
/locus_tag="BCG_0187c"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
misc_feature complement(207959..208618)
/gene="PE1"
/locus_tag="BCG_0187c"
/note="PE-PPE domain; Region: PE-PPE; pfam08237"
/db_xref="CDD:203882"
gene complement(209216..210793)
/gene="PE2"
/locus_tag="BCG_0188c"
/db_xref="GeneID:4695743"
CDS complement(209216..210793)
/gene="PE2"
/locus_tag="BCG_0188c"
/codon_start=1
/transl_table=11
/product="PE family protein"
/protein_id="YP_976287.1"
/db_xref="GI:121636064"
/db_xref="GeneID:4695743"
/translation="MRCRPPSRNRSAHTARNTRPCSLKSRRFTVRFHQTLAAAANSYA
DAEAAIASTRQNQLAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPLPPPSMLTPPI
RCRSVRRALQAVFTPEELYPLTGVRSLVLNTSVEEGLTILHDAIMVELATTGNAVTVF
GWSQSAIIASLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDL
TFYGATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHTKYLDLTPAQ
VEGATKLPTSPGYTGVTDYYIIRTENRPLLQPLRAVPVIGDPLADLIQPNLKVIVNLG
YGDPNYGYSTSYADVRTPFGLWPNVPPQVIADALAAGTQEGILDFTADLQALSAQPLT
LPQIQLPQPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTVDIALALVTTLPLYT
TQLFVRQLAAGNLINAIGYPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLT
DSRRHRRPPTTVYRPRQ"
misc_feature complement(209786..210460)
/gene="PE2"
/locus_tag="BCG_0188c"
/note="PE-PPE domain; Region: PE-PPE; pfam08237"
/db_xref="CDD:219756"
gene complement(211052..211882)
/gene="ptbB"
/locus_tag="BCG_0189c"
/db_xref="GeneID:4699376"
CDS complement(211052..211882)
/gene="ptbB"
/locus_tag="BCG_0189c"
/EC_number="3.1.3.48"
/standard_name="MPtpB"
/note="Differs from Rv0153c by 1aa, G105D"
/codon_start=1
/transl_table=11
/product="phosphotyrosine protein phosphatase ptpB"
/protein_id="YP_976288.1"
/db_xref="GI:121636065"
/db_xref="GeneID:4699376"
/translation="MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATL
RRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLL
TNGGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHC
FAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPE
VVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
"
misc_feature complement(211067..211882)
/gene="ptbB"
/locus_tag="BCG_0189c"
/note="Protein tyrosine/serine phosphatase [Signal
transduction mechanisms]; Region: COG2365"
/db_xref="CDD:32512"
misc_feature complement(211304..211852)
/gene="ptbB"
/locus_tag="BCG_0189c"
/note="Tyrosine phosphatase family; Region:
Y_phosphatase3; pfam13350"
/db_xref="CDD:205530"
misc_feature complement(211058..>211192)
/gene="ptbB"
/locus_tag="BCG_0189c"
/note="Tyrosine phosphatase family C-terminal region;
Region: Y_phosphatase3C; pfam13348"
/db_xref="CDD:205528"
gene complement(211884..213095)
/gene="fadE2"
/locus_tag="BCG_0190c"
/db_xref="GeneID:4697316"
CDS complement(211884..213095)
/gene="fadE2"
/locus_tag="BCG_0190c"
/EC_number="1.3.99.-"
/codon_start=1
/transl_table=11
/product="acyl-CoA dehydrogenase fadE2"
/protein_id="YP_976289.1"
/db_xref="GI:121636066"
/db_xref="GeneID:4697316"
/translation="MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRAAGPADHTAPPI
IEELKTKAKDRGLWNLFLSAESGLTNLEYAPLAEMTGWSMEIAPEALNCAAPDTGNME
ILHMFGTEQQRAQWLRPLLDGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGR
KWWTSGAADPRCKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRH
GHCEIDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALMVNRV
RNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGNKEARHLVAMIKA
VAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGWHRAMRIFDGPDEVHLRSIARAELS
REKSTFAAAVT"
misc_feature complement(211920..213089)
/gene="fadE2"
/locus_tag="BCG_0190c"
/note="Acyl-CoA dehydrogenases similar to fadE2; Region:
ACAD_FadE2; cd01155"
/db_xref="CDD:173844"
misc_feature complement(order(212565..212567,212571..212573,
212670..212675,212694..212696,212700..212702))
/gene="fadE2"
/locus_tag="BCG_0190c"
/note="FAD binding site [chemical binding]; other site"
/db_xref="CDD:173844"
misc_feature complement(order(211968..211973,212334..212336,
212343..212348,212367..212369,212601..212603))
/gene="fadE2"
/locus_tag="BCG_0190c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173844"
misc_feature complement(211968..211970)
/gene="fadE2"
/locus_tag="BCG_0190c"
/note="catalytic base [active]"
/db_xref="CDD:173844"
gene 213519..214619
/gene="pntAa"
/locus_tag="BCG_0191"
/db_xref="GeneID:4699118"
CDS 213519..214619
/gene="pntAa"
/locus_tag="BCG_0191"
/EC_number="1.6.1.2"
/standard_name="pntAA"
/codon_start=1
/transl_table=11
/product="NAD(p) transhydrogenase (subunit alpha) pntAa"
/protein_id="YP_976290.1"
/db_xref="GI:121636067"
/db_xref="GeneID:4699118"
/translation="MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVE
AGAGERALLPDELYTAVGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRN
ADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPM
LTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLD
LGISASGEGGYARELTDDERAQQQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVE
AMKPGSVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPATMPEHASELYSKNIT
ALLDLLIKDGRLAPDFDDEVIAQSCVTRGKDS"
misc_feature 213546..214613
/gene="pntAa"
/locus_tag="BCG_0191"
/note="NAD/NADP transhydrogenase alpha subunit [Energy
production and conversion]; Region: PntA; COG3288"
/db_xref="CDD:225826"
misc_feature 213546..214607
/gene="pntAa"
/locus_tag="BCG_0191"
/note="Rubrum transdehydrogenase NAD-binding and catalytic
domains; Region: Rubrum_tdh; cd05304"
/db_xref="CDD:240629"
misc_feature order(213585..213587,213762..213764,213807..213809,
214386..214388,214464..214466,214470..214472)
/gene="pntAa"
/locus_tag="BCG_0191"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:240629"
misc_feature order(213672..213674,213906..213911,213936..213941,
213948..213953,213960..213965,213969..213974,
213978..213995,213999..214001,214005..214013,
214020..214022,214089..214094,214356..214361,
214485..214490,214500..214502,214509..214514)
/gene="pntAa"
/locus_tag="BCG_0191"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:240629"
misc_feature order(213891..213896,213906..213908,213915..213917,
213924..213926,214047..214058,214116..214124,
214206..214208,214239..214241,214290..214298,
214317..214319,214323..214325)
/gene="pntAa"
/locus_tag="BCG_0191"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:240629"
misc_feature order(213897..213902,213906..213908,213936..213938,
214065..214070,214089..214091,214137..214142,
214146..214157)
/gene="pntAa"
/locus_tag="BCG_0191"
/note="trimer interface B [polypeptide binding]; other
site"
/db_xref="CDD:240629"
misc_feature order(213996..214010,214017..214019,214026..214028,
214095..214097,214101..214103)
/gene="pntAa"
/locus_tag="BCG_0191"
/note="trimer interface A [polypeptide binding]; other
site"
/db_xref="CDD:240629"
gene 214620..214952
/gene="pntAb"
/locus_tag="BCG_0192"
/db_xref="GeneID:4696817"
CDS 214620..214952
/gene="pntAb"
/locus_tag="BCG_0192"
/standard_name="pntAB"
/note="Differs from Rv0156 by 1aa, C2Y"
/codon_start=1
/transl_table=11
/product="NAD(p) transhydrogenase (subunit alpha) pntAb"
/protein_id="YP_976291.1"
/db_xref="GI:121636068"
/db_xref="GeneID:4696817"
/translation="MCNELLENLAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGI
VVLGALVVFGEIEHPSLVLQVILFVAVVFGTLNVIGGFIVTDRMLGMFKAKKPAVPAK
PDRDEALR"
misc_feature 214635..214895
/gene="pntAb"
/locus_tag="BCG_0192"
/note="Domain of unknown function (DUF3814); Region:
DUF3814; pfam12769"
/db_xref="CDD:205065"
gene 214949..216376
/gene="pntB"
/locus_tag="BCG_0193"
/db_xref="GeneID:4696818"
CDS 214949..216376
/gene="pntB"
/locus_tag="BCG_0193"
/EC_number="1.6.1.1"
/codon_start=1
/transl_table=11
/product="NAD(p) transhydrogenase (subunit beta) pntB"
/protein_id="YP_976292.1"
/db_xref="GI:121636069"
/db_xref="GeneID:4696818"
/translation="MNLHYLVEILYIISFSLFIYGLMGLTGPKTAVRGNLIAAAGMTI
AVAATLVMIRHTSQWPLIIAGLVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVAL
IALSEFIDTTGFSAFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRP
IGLGKAQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMVVLP
IGGADMPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGSILTNLMAKAMNRS
IPAIVAGGFGGGGVAPSGGGDDKHVKATSAADAAIQMAYANQVIVVPGYGLAVAQAQH
AVKDLATLLEDRGVPVKYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFART
DVTIVIGANDVTNPAARNETSSPIYGMPILNVDKSRSVIVLKRSMNSGFAGIDNPLFY
ADGTTMLFGDAKKSVTEVSEELKAL"
misc_feature 214952..216364
/gene="pntB"
/locus_tag="BCG_0193"
/note="NAD/NADP transhydrogenase beta subunit [Energy
production and conversion]; Region: PntB; COG1282"
/db_xref="CDD:224201"
misc_feature 214961..216364
/gene="pntB"
/locus_tag="BCG_0193"
/note="NAD(P) transhydrogenase beta subunit; Region: PNTB;
pfam02233"
/db_xref="CDD:216941"
gene 216682..217326
/locus_tag="BCG_0194"
/db_xref="GeneID:4696277"
CDS 216682..217326
/locus_tag="BCG_0194"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976293.1"
/db_xref="GI:121636070"
/db_xref="GeneID:4696277"
/translation="MPSDTSPNGLSRREELLAVATKLFAARGYHGTRMDDVADVIGLN
KATVYHYYASKSLILFDIYRQAAEGTLAAVHDDPSWTAREALYQYTVRLLTAIASNPE
RAAVYFQEQPYITEWFTSEQVAEVREKEQQVYEHVHGLIDRGIASGEFYECDSHVVAL
GYIGMTLGSYRWLRPSGRRTAKEIAAEFSTALLRGLIRDESIRNQSPLGTRKET"
misc_feature 216715..217275
/locus_tag="BCG_0194"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature 216727..216867
/locus_tag="BCG_0194"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
misc_feature 216922..217269
/locus_tag="BCG_0194"
/note="QacR-like protein, C-terminal region; Region:
TetR_C_5; pfam08360"
/db_xref="CDD:203917"
gene complement(217330..218736)
/gene="PE3"
/locus_tag="BCG_0195c"
/db_xref="GeneID:4696051"
CDS complement(217330..218736)
/gene="PE3"
/locus_tag="BCG_0195c"
/note="Differs from Rv0159c by 1aa, T255P"
/codon_start=1
/transl_table=11
/product="PE family protein"
/protein_id="YP_976294.1"
/db_xref="GI:121636071"
/db_xref="GeneID:4696051"
/translation="MSYVIAAPEMLATAAADVDGIGSAIRAASASAAGPTTGLLAAAA
DEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTA
GSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTP
EQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMA
LPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLTFLDMSFNGATPPDSPYQTYMY
TGQYDGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTH
YYMFLTQDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPI
NPIAVASALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTEL
SVLSGALGSVARLIPPIA"
misc_feature complement(218503..218736)
/gene="PE3"
/locus_tag="BCG_0195c"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
misc_feature complement(217609..218280)
/gene="PE3"
/locus_tag="BCG_0195c"
/note="PE-PPE domain; Region: PE-PPE; pfam08237"
/db_xref="CDD:203882"
gene complement(218828..220336)
/gene="PE4"
/locus_tag="BCG_0196c"
/db_xref="GeneID:4698937"
CDS complement(218828..220336)
/gene="PE4"
/locus_tag="BCG_0196c"
/note="Differs from Rv0160c by 2aa, T116A, T211A"
/codon_start=1
/transl_table=11
/product="PE family protein"
/protein_id="YP_976295.1"
/db_xref="GI:121636072"
/db_xref="GeneID:4698937"
/translation="MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAG
DEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHAL
DTINAPIRTLLGRTPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVT
DINKAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTTVNNQLAL
DNKVVAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYI
PFLDVPFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPE
LMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRV
LVDLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGL
IGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT"
misc_feature complement(220097..220336)
/gene="PE4"
/locus_tag="BCG_0196c"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
misc_feature complement(219140..219820)
/gene="PE4"
/locus_tag="BCG_0196c"
/note="PE-PPE domain; Region: PE-PPE; pfam08237"
/db_xref="CDD:203882"
gene 220504..221853
/locus_tag="BCG_0197"
/db_xref="GeneID:4696201"
CDS 220504..221853
/locus_tag="BCG_0197"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976296.1"
/db_xref="GI:121636073"
/db_xref="GeneID:4696201"
/translation="MLTSLVSAVGSHHVTTDPDVLAGRSVDHTGRYRGRASALVRPGS
AEEVAEVLRVCRDAGAYVTVQGGRTSLVAGTVPEHDDVLLSTERLCVVSDVDTVERRI
EIGAGVTLAAVQHAASTAGLVFGVDLSARDTATVGGMASTNAGGLRTVRYGNMGEQVV
GLDVALPDGTVLRRHSRVRRDNTGYDLPALFVGAEGTLGVITALDLRLHPTPSHRVTA
VCGFAELAALVDAGRMFRDVEGIAALELIDGRAAALTREHLGVRPPVEADWLLLVELA
ADHDQTDRLADLLGGARMCGEPAVGVDAAAQQRLWRTRESLAEVLGVYGPPLKFDVSL
PLSAISGFARDAVALVHRHVPDSPEALPLLFGHIGEGNLHLNVLRCPPDREPALYAKM
MGLIAECGGNVSSEHGVGSRKRAYLGMSRQANDVAAMRRVKAALDPTGYLNAAVLFD"
misc_feature 220513..221847
/locus_tag="BCG_0197"
/note="FAD/FMN-containing dehydrogenases [Energy
production and conversion]; Region: GlcD; COG0277"
/db_xref="CDD:223354"
misc_feature 220609..221022
/locus_tag="BCG_0197"
/note="FAD binding domain; Region: FAD_binding_4;
pfam01565"
/db_xref="CDD:216574"
gene complement(221881..223032)
/gene="adhE1"
/locus_tag="BCG_0198c"
/db_xref="GeneID:4698436"
CDS complement(221881..223032)
/gene="adhE1"
/locus_tag="BCG_0198c"
/EC_number="1.1.1.1"
/note="Differs from Rv0162c and Mb0167c by 1aa, R41H"
/codon_start=1
/transl_table=11
/product="zinc-type alcohol dehydrogenase (e subunit)
adhE"
/protein_id="YP_976297.1"
/db_xref="GI:121636074"
/db_xref="GeneID:4698436"
/translation="MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELRLDP
PDRGEVLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAVGQR
VVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVSGF
ATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQSVAVVGLGGVG
MAAVLTALTYTDVRVVAVDQLPEKLSAAKALGAHEIYTPQQATAGGVKAAVVVEAVGH
PAALHTAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIP
RFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL"
misc_feature complement(221896..222990)
/gene="adhE1"
/locus_tag="BCG_0198c"
/note="Zn-dependent alcohol dehydrogenases, class III
[Energy production and conversion]; Region: AdhC; COG1062"
/db_xref="CDD:31262"
misc_feature complement(221902..222990)
/gene="adhE1"
/locus_tag="BCG_0198c"
/note="Medium chain reductase/dehydrogenase
(MDR)/zinc-dependent alcohol dehydrogenase-like family;
Region: MDR; cl16912"
/db_xref="CDD:211475"
misc_feature complement(order(222061..222069,222142..222147,
222262..222264,222307..222309,222319..222324,
222379..222396,222457..222459,222469..222471,
222838..222840,222847..222855))
/gene="adhE1"
/locus_tag="BCG_0198c"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:176178"
gene 223014..223469
/locus_tag="BCG_0199"
/db_xref="GeneID:4697252"
CDS 223014..223469
/locus_tag="BCG_0199"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976298.1"
/db_xref="GI:121636075"
/db_xref="GeneID:4697252"
/translation="MAALPAPEKLLRSDFPVLWPVGTRWADNDMFGHLNNAVYYQLFD
TAINAWINTSTGVDPLAMPVLGIVAESGCRYFSELRFPESLMVGLAVTRLGRSSVTYR
LGVFKEPDDAGVITALGHWVHVYVDRTSRRPVPIPEAIRSLLSTACVSG"
misc_feature 223068..223394
/locus_tag="BCG_0199"
/note="4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes
the final step in the 4-chlorobenzoate degradation pathway
in which 4-chlorobenzoate is converted to
4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT
forms a homotetramer with four active sites; Region: 4HBT;
cd00586"
/db_xref="CDD:238329"
misc_feature order(223143..223145,223215..223217,223296..223307)
/locus_tag="BCG_0199"
/note="active site"
/db_xref="CDD:238329"
gene 223523..224008
/gene="TB18.5"
/locus_tag="BCG_0200"
/db_xref="GeneID:4697507"
CDS 223523..224008
/gene="TB18.5"
/locus_tag="BCG_0200"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976299.1"
/db_xref="GI:121636076"
/db_xref="GeneID:4697507"
/translation="MTAISCSPRPRYASRMPVLSKTVEVTADAASIMAIVADIERYPE
WNEGVKGAWVLARYDDGRPSQVRLDTAVQGIEGTYIHAVYYPGENQIQTVMQQGELFA
KQEQLFSVVATGAASLLTVDMDVQVTMPVPEPMVKMLLNNVLEHLAENLKQRAEQLAA
S"
misc_feature 223568..223987
/gene="TB18.5"
/locus_tag="BCG_0200"
/note="Ligand-binding SRPBCC domain of an uncharacterized
subfamily of proteins; Region: SRPBCC_2; cd07819"
/db_xref="CDD:176861"
misc_feature order(223577..223579,223583..223585,223589..223591,
223616..223624,223628..223633,223667..223669,
223688..223690,223694..223696,223700..223702,
223706..223708,223718..223720,223724..223726,
223763..223765,223769..223771,223844..223849,
223853..223855,223859..223861,223877..223879,
223883..223885,223889..223891,223895..223897,
223913..223927,223943..223951,223958..223966,
223973..223975)
/gene="TB18.5"
/locus_tag="BCG_0200"
/note="putative hydrophobic ligand binding site [chemical
binding]; other site"
/db_xref="CDD:176861"
gene complement(224022..224837)
/locus_tag="BCG_0201c"
/db_xref="GeneID:4697561"
CDS complement(224022..224837)
/locus_tag="BCG_0201c"
/note="In Mycobacterium tuberculosis strain H37Rv, Rv0165c
exists as a single gene. In Mycobacterium bovis BCG
Pasteur, and Mycobacterium bovis, a frameshift due to a 2
bp insertion (*-cc) leads to a product with a different
COOH terminus"
/codon_start=1
/transl_table=11
/product="GntR family transcriptional regulator"
/protein_id="YP_976300.1"
/db_xref="GI:121636077"
/db_xref="GeneID:4697561"
/translation="MIKHDVVWVTLWPERPNNKPPPSPRQVPGNPGPTLKVLASHVNA
PLSAKPRSQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVRE
ALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATIAQELATSATAHITDVEIDE
LDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLAWFLLNAARYMPAQVFAA
DPRWGADAVNSHRQLIAALRRRDTAAVIEHTVWQFTDGARRLTEALAETEVFG"
misc_feature complement(224034..224705)
/locus_tag="BCG_0201c"
/note="Transcriptional regulators [Transcription]; Region:
GntR; COG1802"
/db_xref="CDD:31987"
misc_feature complement(224469..224657)
/locus_tag="BCG_0201c"
/note="Winged helix-turn-helix (WHTH) DNA-binding domain
of the GntR family of transcriptional regulators; Region:
WHTH_GntR; cd07377"
/db_xref="CDD:153418"
misc_feature complement(order(224475..224486,224490..224495,
224523..224525,224532..224537,224541..224555,
224577..224579,224652..224654))
/locus_tag="BCG_0201c"
/note="DNA-binding site [nucleotide binding]; DNA binding
site"
/db_xref="CDD:153418"
misc_feature complement(224103..224441)
/locus_tag="BCG_0201c"
/note="FCD domain; Region: FCD; pfam07729"
/db_xref="CDD:203742"
gene 224892..226556
/gene="fadD5"
/locus_tag="BCG_0203"
/db_xref="GeneID:4697652"
CDS 224892..226556
/gene="fadD5"
/locus_tag="BCG_0203"
/EC_number="2.3.1.86"
/note="activates fatty acids by binding to coenzyme A"
/codon_start=1
/transl_table=11
/product="long-chain-fatty-acid--CoA ligase"
/protein_id="YP_976301.1"
/db_xref="GI:121636078"
/db_xref="GeneID:4697652"
/translation="MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPA
LRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIGAI
AVPLNFRLTPTEIAVLVEDCAAHVMLTEAALAPVAIGVRNIQPLLSVIVVAGGSSQDS
VFGYEDLLNEAGDVHEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYT
SGANINSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVT
GIFLVPAQWQAVCTEQQARPRDLRLRVLSWGAAPAPDALLRQMSATFPETQILAAFGQ
TEMSPVTCMLLGEDAIAKRGSVGRVIPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMS
CYWNNPEATAEAFAGGWFHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVL
ASHPDIAEVAVIGRADEKWGEVPIAVAAVTNDDLRIEDLGEFLTDRLARYKHPKALEI
VDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL"
misc_feature 224919..226538
/gene="fadD5"
/locus_tag="BCG_0203"
/note="long-chain-fatty-acid--CoA ligase; Validated;
Region: PRK07786"
/db_xref="CDD:169098"
misc_feature 224979..>225728
/gene="fadD5"
/locus_tag="BCG_0203"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:213459"
misc_feature 225438..226469
/gene="fadD5"
/locus_tag="BCG_0203"
/note="Bacterial Bile acid CoA ligases and similar
proteins; Region: BACL_like; cd05929"
/db_xref="CDD:213295"
misc_feature order(225453..225455,225462..225479,225483..225488)
/gene="fadD5"
/locus_tag="BCG_0203"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213295"
misc_feature order(225453..225455,225462..225479,225483..225488)
/gene="fadD5"
/locus_tag="BCG_0203"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213270"
misc_feature order(225462..225464,225810..225815,225879..225896,
226131..226133,226167..226169,226176..226178,
226209..226211,226446..226448)
/gene="fadD5"
/locus_tag="BCG_0203"
/note="putative AMP binding site [chemical binding]; other
site"
/db_xref="CDD:213295"
misc_feature order(225462..225464,225585..225590,225732..225734,
225738..225743,225750..225752,225810..225815,
225879..225896,226131..226133,226167..226169,
226176..226178,226200..226211,226389..226391)
/gene="fadD5"
/locus_tag="BCG_0203"
/note="putative active site [active]"
/db_xref="CDD:213295"
misc_feature order(225585..225587,225738..225743,225750..225752,
225810..225812,226200..226208,226371..226373,
226389..226391)
/gene="fadD5"
/locus_tag="BCG_0203"
/note="putative CoA binding site [chemical binding]; other
site"
/db_xref="CDD:213295"
gene 226760..227557
/gene="yrbE1A"
/locus_tag="BCG_0204"
/db_xref="GeneID:4696272"
CDS 226760..227557
/gene="yrbE1A"
/locus_tag="BCG_0204"
/codon_start=1
/transl_table=11
/product="integral membrane protein YrbE1a"
/protein_id="YP_976302.1"
/db_xref="GI:121636079"
/db_xref="GeneID:4696272"
/translation="MTTSTTLGGYVRDQLQTPLTLVGGFFRMCVLTGKALFRWPFQWR
EFILQCWFIMRVGFLPTIMVSIPLTVLLIFTLNILLAQFGAADISGSGAAIGAVTQLG
PLTTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVLASMLVATLL
NGLVITVGLVGGFLFGVYLQNVSGGAYLATLTLITGLPEVVIATIKAATFGLIAGLVG
CYRGLTVRGGSKGLGTAVNETVVLCVIALFAVNVILTTIGVRFGTGR"
misc_feature 226784..227548
/gene="yrbE1A"
/locus_tag="BCG_0204"
/note="ABC-type transport system involved in resistance to
organic solvents, permease component [Secondary
metabolites biosynthesis, transport, and catabolism];
Region: Ttg2B; COG0767"
/db_xref="CDD:223838"
misc_feature 226889..227530
/gene="yrbE1A"
/locus_tag="BCG_0204"
/note="Permease; Region: Permease; pfam02405"
/db_xref="CDD:145511"
gene 227559..228428
/gene="yrbE1B"
/locus_tag="BCG_0205"
/db_xref="GeneID:4697801"
CDS 227559..228428
/gene="yrbE1B"
/locus_tag="BCG_0205"
/codon_start=1
/transl_table=11
/product="integral membrane protein YrbE1b"
/protein_id="YP_976303.1"
/db_xref="GI:121636080"
/db_xref="GeneID:4697801"
/translation="MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIG
QIAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGN
IGVEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIK
SISFLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPD
DVFWSFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAAL
ALYGVDPNFNLTV"
misc_feature 227580..228275
/gene="yrbE1B"
/locus_tag="BCG_0205"
/note="ABC-type transport system involved in resistance to
organic solvents, permease component [Secondary
metabolites biosynthesis, transport, and catabolism];
Region: Ttg2B; COG0767"
/db_xref="CDD:223838"
misc_feature 227805..228275
/gene="yrbE1B"
/locus_tag="BCG_0205"
/note="Permease; Region: Permease; pfam02405"
/db_xref="CDD:145511"
gene 228433..229797
/gene="mce1A"
/locus_tag="BCG_0206"
/db_xref="GeneID:4697802"
CDS 228433..229797
/gene="mce1A"
/locus_tag="BCG_0206"
/standard_name="mce1"
/note="Differs from Rv0169 by 2aa, A313S, S359P;
Differs from Rv0169 by 2aa, A313S, S359P"
/codon_start=1
/transl_table=11
/product="MCE-family protein mce1A"
/protein_id="YP_976304.1"
/db_xref="GI:121636081"
/db_xref="GeneID:4697802"
/translation="MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPK
TQLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIHLI
PANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEINTLFQTLTSIA
EKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDLNSRMPQSRHDIQQLAALG
DVYADAAPDLFDFLDSSVTTARTINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQR
GVADLVPTATLLDTYSPELFCTIRNFYDADPLAKAAAGGGNGYSLRTNSEILSGIGIS
LLSPLALATNGAAIGIGLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVN
ARGGPGGAPGCWQPITRDLWPAPYLVMDTGASLAPYNHMEVGSPYAVEYVWGRQVGDN
TINP"
misc_feature 228532..229353
/gene="mce1A"
/locus_tag="BCG_0206"
/note="virulence factor Mce family protein; Region:
Mtu_fam_mce; TIGR00996"
/db_xref="CDD:188100"
misc_feature 228559..228810
/gene="mce1A"
/locus_tag="BCG_0206"
/note="mce related protein; Region: MCE; pfam02470"
/db_xref="CDD:111376"
misc_feature 228892..229794
/gene="mce1A"
/locus_tag="BCG_0206"
/note="Protein of unknown function (DUF3407); Region:
DUF3407; pfam11887"
/db_xref="CDD:152323"
gene 229794..230834
/gene="mce1B"
/locus_tag="BCG_0207"
/db_xref="GeneID:4695351"
CDS 229794..230834
/gene="mce1B"
/locus_tag="BCG_0207"
/standard_name="mceD"
/note="Differs from Rv0170 by 1aa, T179I"
/codon_start=1
/transl_table=11
/product="MCE-family protein mce1B"
/protein_id="YP_976305.1"
/db_xref="GI:121636082"
/db_xref="GeneID:4695351"
/translation="MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFS
NVSGLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYSDL
IGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVFRALDPAKVNN
IANALITVFQGQGGTINDTLDQTAQLTSQIAERDQAIGEVVKNLNIVLDTTVKHRKEF
DETVNNLENLITGLRNHSDQLAGGLAHISNGAGTVADLLAENRTLVRKAVSYLDAIQQ
PVIDQRVELDDLLHKTPTALTALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVK
LFSQPTGRCTPQ"
misc_feature 229818..230687
/gene="mce1B"
/locus_tag="BCG_0207"
/note="virulence factor Mce family protein; Region:
Mtu_fam_mce; TIGR00996"
/db_xref="CDD:233227"
misc_feature 229896..230132
/gene="mce1B"
/locus_tag="BCG_0207"
/note="mce related protein; Region: MCE; pfam02470"
/db_xref="CDD:217055"
misc_feature 230235..>230588
/gene="mce1B"
/locus_tag="BCG_0207"
/note="Protein of unknown function (DUF3407); Region:
DUF3407; pfam11887"
/db_xref="CDD:221291"
gene 230831..232378
/gene="mce1C"
/locus_tag="BCG_0208"
/db_xref="GeneID:4697196"
CDS 230831..232378
/gene="mce1C"
/locus_tag="BCG_0208"
/note="Differs from Rv0171 by 1aa, D212E"
/codon_start=1
/transl_table=11
/product="MCE-family protein mce1C"
/protein_id="YP_976306.1"
/db_xref="GI:121636083"
/db_xref="GeneID:4697196"
/translation="MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYG
QFTDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNTIGTESRLAIRTDTI
LGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKAASGWDIETVKRSLNV
LSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITHLLAQANQVASILGDRSDQVDRLL
VNAKTLIAAFNERGRAVDALLGNISAFSAQVQNLINDNPNLNHVLEQLRILTDLLVDR
KEDLAETLTILGRFSASFGETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPED
FWRSAGLPAYRWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADGL
PRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAPGLPIAGRPGEVPPNVP
GTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGPPAPPGPGPQLPAPFINPGGTGGSG
VTGGSEN"
misc_feature 230861..231709
/gene="mce1C"
/locus_tag="BCG_0208"
/note="virulence factor Mce family protein; Region:
Mtu_fam_mce; TIGR00996"
/db_xref="CDD:233227"
misc_feature 230942..231169
/gene="mce1C"
/locus_tag="BCG_0208"
/note="mce related protein; Region: MCE; pfam02470"
/db_xref="CDD:217055"
gene 232375..233967
/gene="mce1D"
/locus_tag="BCG_0209"
/db_xref="GeneID:4697197"
CDS 232375..233967
/gene="mce1D"
/locus_tag="BCG_0209"
/codon_start=1
/transl_table=11
/product="MCE-family protein mce1D"
/protein_id="YP_976307.1"
/db_xref="GI:121636084"
/db_xref="GeneID:4697197"
/translation="MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKL
TNNTVVAYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPANAS
AVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRDSVSHIIDELG
PTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALNALNEGRGDFFAVVRSLAL
FVNALHQDDQQFVALNKNLAEFTDRLTHSDADLSNAIQQFDSLLAVARPFFAKNREVL
THDVNNLATVTTTLLQPDPLDGLETVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFA
NPMEFICSSIQAGSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEI
AYSEPRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLTP
ESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPPPPPGPDVIP
GPVPPTPAPVGAPLPAEAGGGQ"
misc_feature 232498..233310
/gene="mce1D"
/locus_tag="BCG_0209"
/note="virulence factor Mce family protein; Region:
Mtu_fam_mce; TIGR00996"
/db_xref="CDD:233227"
misc_feature 232510..232737
/gene="mce1D"
/locus_tag="BCG_0209"
/note="mce related protein; Region: MCE; pfam02470"
/db_xref="CDD:217055"
gene 233964..235136
/gene="lprK"
/locus_tag="BCG_0210"
/db_xref="GeneID:4697198"
CDS 233964..235136
/gene="lprK"
/locus_tag="BCG_0210"
/standard_name="mce1E"
/codon_start=1
/transl_table=11
/product="mce family lipoprotein LprK"
/protein_id="YP_976308.1"
/db_xref="GI:121636085"
/db_xref="GeneID:4697198"
/translation="MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGG
PGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLKKDVTL
PKNATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTIPLKRSSAYPTTEQTLASIAT
LLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNR
LLAYVGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDL
HQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYS
AIDNAFLTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC"
misc_feature 234051..234890
/gene="lprK"
/locus_tag="BCG_0210"
/note="virulence factor Mce family protein; Region:
Mtu_fam_mce; TIGR00996"
/db_xref="CDD:233227"
misc_feature 234114..234341
/gene="lprK"
/locus_tag="BCG_0210"
/note="mce related protein; Region: MCE; pfam02470"
/db_xref="CDD:217055"
gene 235130..236677
/gene="mce1F"
/locus_tag="BCG_0211"
/db_xref="GeneID:4698588"
CDS 235130..236677
/gene="mce1F"
/locus_tag="BCG_0211"
/note="Differs from Rv0174 by 1aa, P370L"
/codon_start=1
/transl_table=11
/product="MCE-family protein mce1F"
/protein_id="YP_976309.1"
/db_xref="GI:121636086"
/db_xref="GeneID:4698588"
/translation="MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKA
DLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVHSVS
AVGEQYIDLVSTGAPGKYFSSGQTITKGTVPSEIGPALDNSNRGLAALPTEKIGLLLD
ETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERW
ARKLNNLAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLK
RYHAGVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSP
ADTSPRPLPSGTYCKIPQDAQLQVRGARNIPCVDVPGKRAATPKECRSKDPYVPLGTN
PWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQ
RPGSGTVQCNGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWK
EMLAPAS"
misc_feature 235154..236014
/gene="mce1F"
/locus_tag="BCG_0211"
/note="virulence factor Mce family protein; Region:
Mtu_fam_mce; TIGR00996"
/db_xref="CDD:233227"
misc_feature 235247..235465
/gene="mce1F"
/locus_tag="BCG_0211"
/note="mce related protein; Region: MCE; pfam02470"
/db_xref="CDD:217055"
gene 236713..237354
/locus_tag="BCG_0212"
/db_xref="GeneID:4697199"
CDS 236713..237354
/locus_tag="BCG_0212"
/codon_start=1
/transl_table=11
/product="mce associated membrane protein"
/protein_id="YP_976310.1"
/db_xref="GI:121636087"
/db_xref="GeneID:4697199"
/translation="MKAADSAESDAGADQTGPQVKAADSAESDAGELGEDACPEQALV
ERRPSRLRRGWLVGIAATLLALAGGLGAAGYFALRSHQESQSIAREDLAAIEAAKDCV
AATQAPDAGAMSASMQKIIECGTGDFGAQASLYTSMLVEAYQAASVHVQVTDMRAAVE
RNNNDGSVDVLVALRVKVSNTDSDAHEVGYRLRVRMALDEGRYKIAKLDQVTK"
gene 237351..238319
/locus_tag="BCG_0213"
/db_xref="GeneID:4697872"
CDS 237351..238319
/locus_tag="BCG_0213"
/note="Differs from Mb0182 by 1aa, S285N, and from Rv0176
by 3aa, S285N, S290Q, A291S"
/codon_start=1
/transl_table=11
/product="mce associated transmembrane protein"
/protein_id="YP_976311.1"
/db_xref="GI:121636088"
/db_xref="GeneID:4697872"
/translation="MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATM
ALTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGS
AIGPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVI
RRLTAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPET
VQRDFERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFM
QGERGTPPSQRYISATVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK"
misc_feature 237411..237785
/locus_tag="BCG_0213"
/note="RDD family; Region: RDD; pfam06271"
/db_xref="CDD:203419"
gene 238316..238870
/locus_tag="BCG_0214"
/db_xref="GeneID:4697011"
CDS 238316..238870
/locus_tag="BCG_0214"
/codon_start=1
/transl_table=11
/product="mce associated protein"
/protein_id="YP_976312.1"
/db_xref="GI:121636089"
/db_xref="GeneID:4697011"
/translation="MSPRRKFEPGEGALLAPQSIEPSRRWGLPLALTASAVVMAAAIS
ACALMRISHESHQRAAHKDIVMLSDVRSFMTMFTSPDPFHANEYAERVLSHATGDFAK
QYHERANDILIRISGVEPTTGTVLDAGVQRWNEDGSANVLVVTQITSKSADGKRVVSN
ANRWLVTAKQEGNEWKISSLLPVI"
gene 238837..239571
/locus_tag="BCG_0215"
/db_xref="GeneID:4696892"
CDS 238837..239571
/locus_tag="BCG_0215"
/codon_start=1
/transl_table=11
/product="MCE associated membrane protein"
/protein_id="YP_976313.1"
/db_xref="GI:121636090"
/db_xref="GeneID:4696892"
/translation="MEDQQSASGDLTQKSVANGESTDTASAATEGHRGEIDAAGEPDE
RGAAVADSQADEDDSAATAARGGKTRARRSRGRRLAITVGVAAALFVGSAAFAGATVE
PYLSERAVVATKLMVARTAANAITTLWTYTPENMDTLADRAANYLSGDFAAQYRRFVD
QIAAANKQAKITNDTEVTGAAVESLSGRDAVAIVYTNTTTTSPVTKNIPALKYLSYRL
FMKRYDARWLVTRMTTITSLDLTPQV"
misc_feature <239158..239391
/locus_tag="BCG_0215"
/note="indolepyruvate ferredoxin oxidoreductase;
Validated; Region: PRK09193"
/db_xref="CDD:169705"
gene complement(239602..240711)
/gene="lprO"
/locus_tag="BCG_0216c"
/db_xref="GeneID:4696358"
CDS complement(239602..240711)
/gene="lprO"
/locus_tag="BCG_0216c"
/note="Differs from Rv0179c by 1aa, H124R"
/codon_start=1
/transl_table=11
/product="lipoprotein lprO"
/protein_id="YP_976314.1"
/db_xref="GI:121636091"
/db_xref="GeneID:4696358"
/translation="MWIRAERVAVLTPTASLRRLTACYAALAVCAALACTTGQPAARA
ADGREMLAQAIATTRGSYLVYNFGGGHPMPLLNAGGHWYEMNNGGHLMIIKNASQRLS
PHLLVDTHTGDQARCEHNPGAHTGEGLWQASEIYPPLKAWQRMGRPTIAVNANFFDVR
GQKGGSWRSTGCSSPLGAYVDNTRGQGRANQAVTGTVAYAGKQGLSGGNELWSSLTTM
ILPVGGAPYVLRPKSRQDYDLATPVIEDLLNKNARFVAVAGIGLLSPGNTGQLHDGGP
SAARTALAYAKQKDEMYIFQGGNYTPDNIQDLFRGLGSDTAILLDGGGSSAIVLRRDT
GGMWAGAGSPKGSCDTRQVLCDSHERALPSWLAFN"
misc_feature complement(239716..>239892)
/gene="lprO"
/locus_tag="BCG_0216c"
/note="Predicted periplasmic protein (DUF2233); Region:
DUF2233; pfam09992"
/db_xref="CDD:220508"
gene complement(240791..242149)
/locus_tag="BCG_0217c"
/db_xref="GeneID:4698591"
CDS complement(240791..242149)
/locus_tag="BCG_0217c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976315.1"
/db_xref="GI:121636092"
/db_xref="GeneID:4698591"
/translation="MSQAQPRPAAPNPKRNVKAIRTVRFWMAPIATTLALMSALAALY
LGGILNPMTNLRHFPIALVNEDAGPAGQQIVDGLVSGLDKNKFDIRVVSPDEARRLLD
TAAVYGSALIPPTFSSQLRDFGASAVTPTRTDRPAITISTNPRAGTLAASIAGQTLTR
ALTVVNGKVGERLTAEVAAQTGGVALAGAAAAGLASPIDVKSTAYNPLPNGTGNGLSA
FYYALLLLLAGFTGSIVVSTLVDSMLGYVPAEFGPVYRFAEQVNISRFRTLLVKWAVM
VVLALLTSGVYLAIAHGLGMPIPLGWQVWLYGVFAIIAVGVTSSSLIAVLGSMGLLVS
MLIFVILGLPSAGATVPLEAVPAFFRWLAQFEPMHQVFLGVRSLLYLNGNADAGLSQA
LTMTSIGLIIGLLLGGFITHLYDRSSFHRIPGAVEMAIAVEHQAQYQARQSARESSSE
QP"
misc_feature complement(<240800..242119)
/locus_tag="BCG_0217c"
/note="Predicted membrane protein [Function unknown];
Region: COG1511"
/db_xref="CDD:224428"
misc_feature complement(241637..>242002)
/locus_tag="BCG_0217c"
/note="YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm;
TIGR03061"
/db_xref="CDD:132105"
misc_feature complement(240965..>241354)
/locus_tag="BCG_0217c"
/note="YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm;
TIGR03062"
/db_xref="CDD:234099"
gene complement(242176..242910)
/locus_tag="BCG_0218c"
/db_xref="GeneID:4697013"
CDS complement(242176..242910)
/locus_tag="BCG_0218c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976316.1"
/db_xref="GI:121636093"
/db_xref="GeneID:4697013"
/translation="MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLL
VNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGI
LHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAA
LTLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDAD
ARGLTANEPSEVLIWEMHAKLGDSAT"
misc_feature complement(242179..242895)
/locus_tag="BCG_0218c"
/note="Pirin-related protein [General function prediction
only]; Region: COG1741"
/db_xref="CDD:224655"
misc_feature complement(242545..242874)
/locus_tag="BCG_0218c"
/note="Pirin; Region: Pirin; pfam02678"
/db_xref="CDD:217181"
gene complement(242927..244039)
/gene="sigG"
/locus_tag="BCG_0219c"
/db_xref="GeneID:4695936"
CDS complement(242927..244039)
/gene="sigG"
/locus_tag="BCG_0219c"
/EC_number="2.7.7.6"
/note="DNA-dependent RNA polymerase catalyzes the
transcription of DNA into RNA using the four
ribonucleoside triphosphates as substrates"
/codon_start=1
/transl_table=11
/product="RNA polymerase factor sigma-70"
/protein_id="YP_976317.1"
/db_xref="GI:121636094"
/db_xref="GeneID:4695936"
/translation="MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAE
NSGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFA
GKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPD
VTDDPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTST
VAVNSLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTA
EAIWEMPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVH
LPFQLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL"
misc_feature complement(242930..243895)
/gene="sigG"
/locus_tag="BCG_0219c"
/note="RNA polymerase factor sigma-70; Validated; Region:
PRK08241"
/db_xref="CDD:236196"
misc_feature complement(243674..243853)
/gene="sigG"
/locus_tag="BCG_0219c"
/note="Sigma-70 region 2; Region: Sigma70_r2; pfam04542"
/db_xref="CDD:218138"
misc_feature complement(243341..243487)
/gene="sigG"
/locus_tag="BCG_0219c"
/note="Sigma70, region (SR) 4 refers to the most
C-terminal of four conserved domains found in Escherichia
coli (Ec) sigma70, the main housekeeping sigma, and
related sigma-factors (SFs). A SF is a dissociable subunit
of RNA polymerase, it directs bacterial or...; Region:
Sigma70_r4; cd06171"
/db_xref="CDD:100119"
misc_feature complement(order(243353..243355,243359..243364,
243368..243376,243380..243385,243389..243391,
243419..243424,243440..243442,243470..243472))
/gene="sigG"
/locus_tag="BCG_0219c"
/note="DNA binding residues [nucleotide binding]"
/db_xref="CDD:100119"
misc_feature complement(<243059..243277)
/gene="sigG"
/locus_tag="BCG_0219c"
/note="SnoaL-like domain; Region: SnoaL_2; pfam12680"
/db_xref="CDD:221707"
gene 243987..244826
/locus_tag="BCG_0220"
/db_xref="GeneID:4695354"
CDS 243987..244826
/locus_tag="BCG_0220"
/EC_number="3.1.-.-"
/codon_start=1
/transl_table=11
/product="lysophospholipase"
/protein_id="YP_976318.1"
/db_xref="GI:121636095"
/db_xref="GeneID:4695354"
/translation="MTTTRTERNFAGIGDVRIVYDVWTPDTAPQAVVVLAHGLGEHAR
RYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLVGIATREYPGC
KRIVLGHSMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPG
LPVQELDFTAISRDPEVVQAYNTDPLVHHGRVPAGIGRALLQVGETMPRRAPALTAPL
LVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNEPERNQVLDDVVAWLT
ERL"
misc_feature 243987..244823
/locus_tag="BCG_0220"
/note="Lysophospholipase [Lipid metabolism]; Region: PldB;
COG2267"
/db_xref="CDD:225176"
misc_feature 244029..244262
/locus_tag="BCG_0220"
/note="Putative lysophospholipase; Region: Hydrolase_4;
pfam12146"
/db_xref="CDD:221442"
gene 244868..245617
/locus_tag="BCG_0221"
/db_xref="GeneID:4697419"
CDS 244868..245617
/locus_tag="BCG_0221"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976319.1"
/db_xref="GI:121636096"
/db_xref="GeneID:4697419"
/translation="MTNDKMLARIAALLRQAEGTDNPHEADAFMSTAQRLATAASIDL
AVARSHAGNRSPAQAPTQRTITIGAAGTRGLRTYVQLFVLIAAANDVRCDVASNSTFV
YAYGFAEDIDTSHALYASLVVQMVRASDAYLASGAHRPTPTITARLNFQLAFGARVGQ
RLADAREQTRQEATKDRDRPPGTAIALRDKDIELHEYYRRSSKARGAWRASRATAGYS
SAARRAGDRAGRQARLGNNPELPGARAALGR"
misc_feature 244877..245002
/locus_tag="BCG_0221"
/note="Protein of unknown function (DUF2786); Region:
DUF2786; pfam10979"
/db_xref="CDD:220922"
gene 245614..246123
/locus_tag="BCG_0222"
/db_xref="GeneID:4695540"
CDS 245614..246123
/locus_tag="BCG_0222"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976320.1"
/db_xref="GI:121636097"
/db_xref="GeneID:4695540"
/translation="MIGADVPRDSQRARVYAAEAFVRTLFDRVTAHGSPTVEFFGTQL
TLPPEGRFGSVASVQRYVDDVLALPAVGQNWPTVSPVRVRARRAATAAHYENHGGTGT
IAVPDRHTAGWAMRELVVLHEVAHHLCQVPPPHGPEFVATVCTLTELVMGPEVGHVFR
VVYAQEGVR"
misc_feature 245635..246117
/locus_tag="BCG_0222"
/note="putative metallohydrolase, TIGR04338 family;
Region: HEXXH_Rv0185"
/db_xref="CDD:234552"
gene 246168..248243
/gene="bglS"
/locus_tag="BCG_0223"
/db_xref="GeneID:4697390"
CDS 246168..248243
/gene="bglS"
/locus_tag="BCG_0223"
/EC_number="3.2.1.21"
/note="Differs from Mb0192 by 1aa, S504I, and from Rv0186
by 2aa, S504I, R532P"
/codon_start=1
/transl_table=11
/product="beta-glucosidase bglS"
/protein_id="YP_976321.1"
/db_xref="GI:121636098"
/db_xref="GeneID:4697390"
/translation="MTDDERFSLLVGLTGASDLWPVRDERIPQGVPMCAGYVPGIPRL
GVPALLMSDAGLGVTNPGYRPGDTATALPAGLALAASFNPVLARSSGKAIGREARSRG
FNVQLAGAINLARDPRNGRNFEYLSEDPLLSATMAAESIIGIQQQGVIATTKHFSLNC
NETNRHWLDAVIDPDAHRESDLLAFEIVIERSQPGAVMAAYNKVNGDYAAGNDHLLND
VLKGAWGYRGWVMSDWGGTPSWECALAGLDQECGAQIDAVLWQSEAFTDRLRAAYADG
NLPKGRLSDMVRRILRSMFAVGIDRWKPAPAPDMNAHNEIAAQMARQGIVLLQNRGLL
PLAPESAGRIAVIGGYAHLGVPAGYGSSAVTPPGGYAGVIPIGGSGLAAGLRNLYLLP
SSPLSELRKRLPNAQFEFDPGINPAEAVLAARRADIAIVFAIRAEGEGFDSADLSLPW
GQDALIAAVASANANTVVVLETGNPVTMPWRDSVNAIMQAWYPGQAGGQAVAESVTGQ
VNPSGRLPITFPVDLGQTPRSQPRELGAPWGTSTTIHYTEGADVGYRWFASTNQTPMF
AFGHGLSYTSFEYRDLVVTGGHTVHASFSVTNTGDRSGADVPQLYMIAAPGESRLRLL
GFERVELEPGQTRRVRIEADPRLLARYDGEARSWRIEPGGYTVAVGASAVALKLAAKV
KLAGRGFGR"
misc_feature 246249..247043
/gene="bglS"
/locus_tag="BCG_0223"
/note="Glycosyl hydrolase family 3 N terminal domain;
Region: Glyco_hydro_3; pfam00933"
/db_xref="CDD:201514"
misc_feature 246261..247319
/gene="bglS"
/locus_tag="BCG_0223"
/note="Beta-glucosidase-related glycosidases [Carbohydrate
transport and metabolism]; Region: BglX; COG1472"
/db_xref="CDD:31661"
misc_feature 247140..247892
/gene="bglS"
/locus_tag="BCG_0223"
/note="Glycosyl hydrolase family 3 C-terminal domain;
Region: Glyco_hydro_3_C; pfam01915"
/db_xref="CDD:190157"
misc_feature 247983..248168
/gene="bglS"
/locus_tag="BCG_0223"
/note="Fibronectin type III-like domain; Region: Fn3-like;
pfam14310"
/db_xref="CDD:206478"
gene 248604..249266
/locus_tag="BCG_0224"
/db_xref="GeneID:4696688"
CDS 248604..249266
/locus_tag="BCG_0224"
/EC_number="2.1.1.-"
/note="Differs from Rv0187 and Mb0193 by 1aa, V147A"
/codon_start=1
/transl_table=11
/product="o-methyltransferase"
/protein_id="YP_976322.1"
/db_xref="GI:121636099"
/db_xref="GeneID:4696688"
/translation="MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAV
SAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVAR
VNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVVYIQWAIRLARRGA
VIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALAL
VR"
misc_feature 248604..249263
/locus_tag="BCG_0224"
/note="Predicted O-methyltransferase [General function
prediction only]; Region: COG4122"
/db_xref="CDD:33879"
misc_feature 248790..249095
/locus_tag="BCG_0224"
/note="S-adenosylmethionine-dependent methyltransferases
(SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
that use S-adenosyl-L-methionine (SAM or AdoMet) as a
substrate for methyltransfer, creating the product
S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
cd02440"
/db_xref="CDD:100107"
misc_feature order(248802..248822,248877..248882,248958..248966)
/locus_tag="BCG_0224"
/note="S-adenosylmethionine binding site [chemical
binding]; other site"
/db_xref="CDD:100107"
gene 249385..249816
/locus_tag="BCG_0225"
/db_xref="GeneID:4697406"
CDS 249385..249816
/locus_tag="BCG_0225"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976323.1"
/db_xref="GI:121636100"
/db_xref="GeneID:4697406"
/translation="MSTVHSSIDQHPDLLALRASFDRAAESTIAHFTFGLALLAGLYV
AASPWIVGFSATRGLPTCDLIVGIAVAYLAYGFASALDRTHGMTWTLPVLGVWVIFSP
WVLPGVAVTAGMMWSHIIAGAVVAVLGFYFGMRTRAAANQG"
misc_feature <249523..249633
/locus_tag="BCG_0225"
/note="SPW repeat; Region: SPW; pfam03779"
/db_xref="CDD:202765"
misc_feature 249643..249798
/locus_tag="BCG_0225"
/note="SPW repeat; Region: SPW; pfam03779"
/db_xref="CDD:202765"
gene complement(249895..251622)
/gene="ilvD"
/locus_tag="BCG_0226c"
/db_xref="GeneID:4697026"
CDS complement(249895..251622)
/gene="ilvD"
/locus_tag="BCG_0226c"
/EC_number="4.2.1.9"
/note="catalyzes the dehydration of
2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate
in valine and isoleucine biosynthesis"
/codon_start=1
/transl_table=11
/product="dihydroxy-acid dehydratase"
/protein_id="YP_976324.1"
/db_xref="GI:121636101"
/db_xref="GeneID:4697026"
/translation="MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDD
EDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGYPLEFGTISVSDGISMGH
EGMHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYA
GSILPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGACGGMY
TANTMASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEA
FENAIAVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVM
SDVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPI
HPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAALDALEDGTITVGDAV
VIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHIAPEAVD
GGPIALLRNGDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVS
SAAVGAVCG"
misc_feature complement(249901..251568)
/gene="ilvD"
/locus_tag="BCG_0226c"
/note="dihydroxy-acid dehydratase; Provisional; Region:
PRK00911"
/db_xref="CDD:234861"
misc_feature complement(249901..251538)
/gene="ilvD"
/locus_tag="BCG_0226c"
/note="6-phosphogluconate dehydratase; Region: edd;
TIGR01196"
/db_xref="CDD:130264"
gene 251770..252060
/locus_tag="BCG_0227"
/db_xref="GeneID:4699341"
CDS 251770..252060
/locus_tag="BCG_0227"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976325.1"
/db_xref="GI:121636102"
/db_xref="GeneID:4699341"
/translation="MTAAHGYTQQKDNYAKRLRRVEGQVRGIARMIEEDKYCIDVLTQ
ISAVTSALRSVALNLLDEHLSHCVTRAVAEGGPGADGKLAEASAAIARLVRS"
misc_feature 251800..252045
/locus_tag="BCG_0227"
/note="Transcriptional regulators CsoR (copper-sensitive
operon repressor), RcnR, and FrmR, and related domains;
this domain superfamily was previously known as DUF156;
Region: CsoR-like_DUF156; cd10148"
/db_xref="CDD:197385"
misc_feature order(251800..251802,251809..251814,251821..251826,
251833..251835,251842..251847,251851..251856,
251863..251874,251878..251886,251890..251898,
251902..251907,251911..251916,251923..251928,
251935..251940,251944..251952,251956..251964,
251971..251973,252004..252009,252013..252042)
/locus_tag="BCG_0227"
/note="putative homotetramer interface [polypeptide
binding]; other site"
/db_xref="CDD:197385"
misc_feature order(251800..251802,251809..251814,251821..251826,
251833..251835,251842..251847,251851..251856,
251863..251874,251878..251886,251890..251898,
251902..251907,251911..251916,251923..251928,
251935..251937,251944..251946,251956..251958,
252022..252024,252031..252042)
/locus_tag="BCG_0227"
/note="putative homodimer interface [polypeptide binding];
other site"
/db_xref="CDD:197385"
misc_feature order(251878..251880,251956..251958,252022..252024)
/locus_tag="BCG_0227"
/note="putative allosteric switch controlling residues;
other site"
/db_xref="CDD:197385"
misc_feature order(251881..251883,251956..251958,251968..251970)
/locus_tag="BCG_0227"
/note="putative metal binding site [ion binding]; other
site"
/db_xref="CDD:197385"
misc_feature order(251938..251940,251947..251952,251959..251964,
251968..251973,252004..252009,252013..252021,
252025..252030)
/locus_tag="BCG_0227"
/note="putative homodimer-homodimer interface [polypeptide
binding]; other site"
/db_xref="CDD:197385"
gene 252188..253429
/locus_tag="BCG_0228"
/db_xref="GeneID:4696104"
CDS 252188..253429
/locus_tag="BCG_0228"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976326.1"
/db_xref="GI:121636103"
/db_xref="GeneID:4696104"
/translation="MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGAL
SAIARNLRVSVVLVGTLLSWYALVAAVTTVPLVRWTAHWPRRRALVVSLVCLTVSQLV
SALAPNFAVLAAGRVLCAVTHGLLWAVIAPIATRLVPPSHAGRATTSIYIGTSLALVV
GSPLTAAMSLMWGWRLAAVCVTGAAAAVALAARLALPEMVLRADQLEHVGRRARHHRN
PRLVKVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLLAAYGVAGLVSVPLVA
RPLDRWPKGAVIVGMTGLTAAFTLLTALAFGERHTAATALLGTGAIVLWGALATAVSP
MLQSAAMRSGGDDPDGASGLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVA
LFGMTVSQHLFENPTLSPGDG"
misc_feature 252251..253414
/locus_tag="BCG_0228"
/note="Arabinose efflux permease [Carbohydrate transport
and metabolism]; Region: AraJ; COG2814"
/db_xref="CDD:225371"
misc_feature 252254..>252712
/locus_tag="BCG_0228"
/note="The Major Facilitator Superfamily (MFS) is a large
and diverse group of secondary transporters that includes
uniporters, symporters, and antiporters. MFS proteins
facilitate the transport across cytoplasmic or internal
membranes of a variety of...; Region: MFS; cd06174"
/db_xref="CDD:119392"
misc_feature order(252296..252298,252305..252313,252317..252322,
252371..252373,252380..252385,252392..252394,
252404..252409,252413..252418,252554..252559,
252566..252571,252578..252583,252590..252592,
252626..252631,252638..252643,252659..252661)
/locus_tag="BCG_0228"
/note="putative substrate translocation pore; other site"
/db_xref="CDD:119392"
gene 253506..254564
/locus_tag="BCG_0229"
/db_xref="GeneID:4698256"
CDS 253506..254564
/locus_tag="BCG_0229"
/note="In Mycobacterium tuberculosis strain H37Rv, Rv0192
and Rv0192A exist as 2 genes with an overlap region. In
Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis,
a single base insertion (*-g) leads to a single product.
Differs from Mb0198 by 1aa, A279V and from Rv0192 by 2aa,
P113S, A279V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976327.1"
/db_xref="GI:121636104"
/db_xref="GeneID:4698256"
/translation="MSRWKQGWTRGSLFAALNIAAVVAVLMLGAGVAVADPDAAPGDP
GGPGGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDPLAPPPPDPLAVPVA
AGPVAGQDPTPFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVPIADRAMAESAIHIS
SIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRTGDSLVATADDATHQ
MTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDSSTYGVPVNSAQGYK
LTASDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAKWFYDNFGSGDPVVV
KNSVGTYNKNDGAQDWQI"
misc_feature 253890..254519
/locus_tag="BCG_0229"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: ErfK; COG1376"
/db_xref="CDD:31566"
misc_feature 254130..254507
/locus_tag="BCG_0229"
/note="L,D-transpeptidase catalytic domain; Region: YkuD;
pfam03734"
/db_xref="CDD:202749"
gene complement(254624..256471)
/locus_tag="BCG_0230c"
/db_xref="GeneID:4698698"
CDS complement(254624..256471)
/locus_tag="BCG_0230c"
/note="Differs from Rv0193c and Mb0199c by 1aa, E417K"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976328.1"
/db_xref="GI:121636105"
/db_xref="GeneID:4698698"
/translation="MIQISRDMSSLGQTATTQALPDNSDGIQLTKFAADDILPLEYAP
PIGPELVSQDQLPAAWAYKRFRDLDDKESYRRKLLQELTDALAAQGSEAAEIATAALR
DLIDQMAEQGAVVLADIVESDDFLELVKRYDELMAREGSRSFIHRFLDLRRSPGMLTD
PAVNGALVHPLMIALISYAVGGPIRMIDARGKDAEPLSVLAQDNMLHIDNTPFNDEYK
ILITWRRGTAQGPAGQNFTFLPGTHKLARTCFVNEDGVPWSSENASIFTTPDSIRKVF
DAQRQLGGQDHPTVIEVTDSERPLSSVFAAGSLVHHRFRTASGSARSCIILVFHRVAD
NPGRMVSDVEDSSDVSLSELLTRGVPDESYQQRFIATLCAAADEIAELLLKWKKTPQR
PVSLPLQTKQIDGARFEEWISAATEAPEVREIRNRELTIPYGEVLSAEEFFDLIWRLM
RFDKHGPLDLILYHDNREEPRKWARNLIREMSADRLYERLLGWLADIQQPRPADCLRP
LQIHALISEVLKTLPLDEDQDPPADWHFDLLGMSHAEAARSVKHLLEDVAEALLRCED
MAAYLSTSLFAFWAVDAAYSLDGRRNLVVKDCARRLLRHYTMLSLTCFQ"
gene 256778..260362
/locus_tag="BCG_0231"
/db_xref="GeneID:4698450"
CDS 256778..260362
/locus_tag="BCG_0231"
/note="Differs from Mb0200 by 1aa, I49V, and from Rv0194
by 2aa, T74M, M223T"
/codon_start=1
/transl_table=11
/product="drugs-transport transmembrane ATP-binding
protein ABC transporter"
/protein_id="YP_976329.1"
/db_xref="GI:121636106"
/db_xref="GeneID:4698450"
/translation="MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRV
IDDAIAADHRPLAPWAVVLVAAAGATYLLTYVRRYYGGRIAHLVQHDLRMDAFQALLR
WDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAVMTWLSVPLAL
LAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERET
VKLVMASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFV
AFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSLEARLSL
EFQRVSFGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVR
IGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIE
EFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECG
IQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRYRELL
SPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTNVHNPGPHDHPPGPDPLRRLLREFR
GPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIRWVVQ
WGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLR
TGLVVAVISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARH
RLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVA
LLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVA
AGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTV
VFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFA
GTVRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLL
ALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADR
IVVLEHGTVVEDGAHTELLAAGGHYSRLWAAHTRLCSPEITQLQCIDA"
misc_feature 256868..258469
/locus_tag="BCG_0231"
/note="ABC-type multidrug transport system, ATPase and
permease components [Defense mechanisms]; Region: MdlB;
COG1132"
/db_xref="CDD:31327"
misc_feature 256868..257611
/locus_tag="BCG_0231"
/note="ABC transporter transmembrane region; Region:
ABC_membrane; cl00549"
/db_xref="CDD:207103"
misc_feature 257777..258469
/locus_tag="BCG_0231"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:214148"
misc_feature 257876..257899
/locus_tag="BCG_0231"
/note="Walker A/P-loop; other site"
/db_xref="CDD:213179"
misc_feature order(257885..257890,257894..257902,258020..258022,
258260..258265,258356..258358)
/locus_tag="BCG_0231"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:213179"
misc_feature 258011..258022
/locus_tag="BCG_0231"
/note="Q-loop/lid; other site"
/db_xref="CDD:213179"
misc_feature 258188..258217
/locus_tag="BCG_0231"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:213179"
misc_feature 258248..258265
/locus_tag="BCG_0231"
/note="Walker B; other site"
/db_xref="CDD:213179"
misc_feature 258272..258283
/locus_tag="BCG_0231"
/note="D-loop; other site"
/db_xref="CDD:213179"
misc_feature 258344..258364
/locus_tag="BCG_0231"
/note="H-loop/switch region; other site"
/db_xref="CDD:213179"
misc_feature 258656..260314
/locus_tag="BCG_0231"
/note="ABC-type multidrug transport system, ATPase and
permease components [Defense mechanisms]; Region: MdlB;
COG1132"
/db_xref="CDD:31327"
misc_feature 259601..260302
/locus_tag="BCG_0231"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:214148"
misc_feature 259703..259726
/locus_tag="BCG_0231"
/note="Walker A/P-loop; other site"
/db_xref="CDD:213179"
misc_feature order(259712..259717,259721..259729,259847..259849,
260087..260092,260183..260185)
/locus_tag="BCG_0231"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:213179"
misc_feature 259838..259849
/locus_tag="BCG_0231"
/note="Q-loop/lid; other site"
/db_xref="CDD:213179"
misc_feature 260015..260044
/locus_tag="BCG_0231"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:213179"
misc_feature 260075..260092
/locus_tag="BCG_0231"
/note="Walker B; other site"
/db_xref="CDD:213179"
misc_feature 260099..260110
/locus_tag="BCG_0231"
/note="D-loop; other site"
/db_xref="CDD:213179"
misc_feature 260171..260191
/locus_tag="BCG_0231"
/note="H-loop/switch region; other site"
/db_xref="CDD:213179"
gene 260800..261435
/locus_tag="BCG_0232"
/db_xref="GeneID:4695751"
CDS 260800..261435
/locus_tag="BCG_0232"
/codon_start=1
/transl_table=11
/product="LuxR family two component transcriptional
regulator"
/protein_id="YP_976330.1"
/db_xref="GI:121636107"
/db_xref="GeneID:4695751"
/translation="MAPVNVISVAVVASDPLTRDGALARLSSHRELDVRAWQAGCETS
VLLVLATTITAPLLCQIEDVQKDGPSHAPKLVVVADEFSAEQVFRMIKLGLTGLLYRS
QSTFDCIVETIRLSAEGRLRLPERVQRYLVGRIKSTPTAEPDTPCAAALAEREVAVLR
LLADGLSTHQVAVQLNYCERTIKNIVHDIVTRLKLRNRTHAVAHALRAGLI"
misc_feature 260818..261432
/locus_tag="BCG_0232"
/note="Response regulator containing a CheY-like receiver
domain and an HTH DNA-binding domain [Signal transduction
mechanisms / Transcription]; Region: CitB; COG2197"
/db_xref="CDD:32379"
misc_feature <261289..261420
/locus_tag="BCG_0232"
/note="C-terminal DNA-binding domain of LuxR-like
proteins. This domain contains a helix-turn-helix motif
and binds DNA. Proteins belonging to this group are
response regulators; some act as transcriptional
activators, others as transcriptional repressors. Many...;
Region: LuxR_C_like; cd06170"
/db_xref="CDD:99777"
misc_feature order(261292..261294,261298..261300,261391..261399,
261406..261408,261415..261420)
/locus_tag="BCG_0232"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:99777"
misc_feature order(261298..261306,261328..261333,261337..261342,
261346..261360,261391..261393)
/locus_tag="BCG_0232"
/note="DNA binding residues [nucleotide binding]"
/db_xref="CDD:99777"
gene 261548..262132
/locus_tag="BCG_0233"
/db_xref="GeneID:4695509"
CDS 261548..262132
/locus_tag="BCG_0233"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976331.1"
/db_xref="GI:121636108"
/db_xref="GeneID:4695509"
/translation="MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYF
PGGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAV
SVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEG
AILLARVRRDLTPLDLVHRQLRNLLLAELPERSR"
misc_feature 261560..262066
/locus_tag="BCG_0233"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature 261572..261685
/locus_tag="BCG_0233"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 262132..264378
/locus_tag="BCG_0234"
/db_xref="GeneID:4695763"
CDS 262132..264378
/locus_tag="BCG_0234"
/EC_number="1.-.-.-"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a single base transversion (t-g)
introduces a stop codon that leads to a shorter product
compared to its homolog in Mycobacterium tuberculosis
strain H37Rv (748 aa versus 762 aa). Differs from Rv0197
by 1aa, S378R"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976332.1"
/db_xref="GI:121636109"
/db_xref="GeneID:4695763"
/translation="MTSSDWLPTACILCECNCGIVVQVDDRRLARIRGDKAHPGSAGY
TCNKALRLDHYQNNRARLSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKI
FYYGGGGQGNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGGHTRGEFEN
AEVSVFVGKNPWMSQSFPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPG
CDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELLR
AAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQHLHSSFAPL
FSQVSGRTPVTGAPIIAGLIPGNVVPEEILTEHPDRFRAMIVESGNPAHSLADSAACR
AAFQALELMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFP
PLPGTLPEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVAKL
TAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNALFDAILERPS
GVTFTVHNYEDDFALISHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGER
RAYTANDIFRDPSWRKRDANGALRVSVEDAQALGLADGCLARITTAAGSAEATVEVTE
TMLAGHAALPNGFGLDYTGDDGRTVVAGVAPNALTSTRWRDPYAGTPWHKHVPAAIRR
ADAESPIW"
misc_feature 262132..264357
/locus_tag="BCG_0234"
/note="Anaerobic dehydrogenases, typically
selenocysteine-containing [Energy production and
conversion]; Region: BisC; COG0243"
/db_xref="CDD:30592"
misc_feature 262153..263547
/locus_tag="BCG_0234"
/note="The MopB_1 CD includes a group of related
uncharacterized bacterial molybdopterin-binding
oxidoreductase-like domains with a putative N-terminal
iron-sulfur [4Fe-4S] cluster binding site and
molybdopterin cofactor binding site. These members belong
to...; Region: MopB_1; cd02762"
/db_xref="CDD:73327"
misc_feature order(262162..262164,262171..262173,262183..262185,
262267..262269)
/locus_tag="BCG_0234"
/note="putative [Fe4-S4] binding site [ion binding]; other
site"
/db_xref="CDD:73327"
misc_feature order(262273..262275,262519..262521,262525..262533,
262630..262635,262639..262641,262648..262653,
262723..262731,262789..262791,263008..263019,
263122..263127,263263..263271,263341..263349,
263356..263358,263392..263397,263410..263412)
/locus_tag="BCG_0234"
/note="putative molybdopterin cofactor binding site
[chemical binding]; other site"
/db_xref="CDD:73327"
misc_feature <263761..263940
/locus_tag="BCG_0234"
/note="Molybdopterin-Binding (MopB) domain of the MopB
superfamily of proteins, a large, diverse, heterogeneous
superfamily of enzymes that, in general, bind
molybdopterin as a cofactor. The MopB domain is found in a
wide variety of molybdenum- and...; Region:
Molybdopterin-Binding; cl09928"
/db_xref="CDD:209095"
misc_feature 263971..264354
/locus_tag="BCG_0234"
/note="The MopB_CT_1 CD includes a group of related
uncharacterized bacterial molybdopterin-binding
oxidoreductase-like domains with a putative N-terminal
iron-sulfur [4Fe-4S] cluster binding site and
molybdopterin cofactor binding site. This CD is of the...;
Region: MopB_CT_1; cd02782"
/db_xref="CDD:30314"
misc_feature order(263992..264006,264010..264021,264208..264210,
264271..264273,264331..264336)
/locus_tag="BCG_0234"
/note="putative molybdopterin cofactor binding site; other
site"
/db_xref="CDD:30314"
gene complement(264419..266410)
/locus_tag="BCG_0235c"
/db_xref="GeneID:4696246"
CDS complement(264419..266410)
/locus_tag="BCG_0235c"
/EC_number="3.4.24.-"
/codon_start=1
/transl_table=11
/product="zinc metalloprotease"
/protein_id="YP_976333.1"
/db_xref="GI:121636110"
/db_xref="GeneID:4696246"
/translation="MTLAIPSGIDLSHIDADARPQDDLFGHVNGRWLAEHEIPADRAT
DGAFRSLFDRAETQVRDLIIQASQAGAAVGTDAQRIGDLYASFLDEEAVERAGVQPLH
DELATIDSAADATELAAALGTLQRAGVGGGIGVYVDTDSKDSTRYLVHFTQSGIGLPD
ESYYRDEQHAAVLAAYPGHIARMFGLVYGGESRDHAKTADRIVALETKLADAHWDVVK
RRDADLGYNLRTFAQLQTEGAGFDWVSWVTALGSAPDAMTELVVRQPDYLVTFASLWA
SVNVEDWKCWARWRLIRARAPWLTRALVAEDFEFYGRTLTGAQQLRDRWKRGVSLVEN
LMGDAVGKLYVQRHFPPDAKSRIDTLVDNLQEAYRISISELDWMTPQTRQRALAKLNK
FTAKVGYPIKWRDYSKLAIDRDDLYGNVQRGYAVNHDRELAKLFGPVDRDEWFMTPQT
VNAYYNPGMNEIVFPAAILQPPFFDPQADEAANYGGIGAVIGHEIGHGFDDQGAKYDG
DGNLVDWWTDDDRTEFAARTKALIEQYHAYTPRDLVDHPGPPHVQGAFTIGENIGDLG
GLSIALLAYQLSLNGNPAPVIDGLTGMQRVFFGWAQIWRTKSRAAEAIRRLAVDPHSP
PEFRCNGVVRNVDAFYQAFDVTEDDALFLDPQRRVRIWN"
misc_feature complement(264425..266410)
/locus_tag="BCG_0235c"
/note="Predicted metalloendopeptidase [Posttranslational
modification, protein turnover, chaperones]; Region: PepO;
COG3590"
/db_xref="CDD:226118"
misc_feature complement(264431..266359)
/locus_tag="BCG_0235c"
/note="Peptidase family M13 includes neprilysin,
endothelin-converting enzyme I; Region: M13; cd08662"
/db_xref="CDD:189000"
misc_feature complement(order(264527..264529,264545..264547,
264608..264613,264731..264733,264920..264922,
264929..264934,264941..264943,265052..265057))
/locus_tag="BCG_0235c"
/note="active site"
/db_xref="CDD:189000"
misc_feature complement(order(264731..264733,264920..264922,
264932..264934))
/locus_tag="BCG_0235c"
/note="Zn binding site [ion binding]; other site"
/db_xref="CDD:189000"
gene 266453..267112
/locus_tag="BCG_0236"
/db_xref="GeneID:4696352"
CDS 266453..267112
/locus_tag="BCG_0236"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976334.1"
/db_xref="GI:121636111"
/db_xref="GeneID:4696352"
/translation="MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGI
ASTLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDAS
LQRLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAAR
PVVTTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESI
R"
gene 267109..267798
/locus_tag="BCG_0237"
/db_xref="GeneID:4696349"
CDS 267109..267798
/locus_tag="BCG_0237"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976335.1"
/db_xref="GI:121636112"
/db_xref="GeneID:4696349"
/translation="MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVL
LVVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRD
FNRDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLA
RRGVTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGW
LVLDVTPINAR"
gene complement(267795..268298)
/locus_tag="BCG_0238c"
/db_xref="GeneID:4696741"
CDS complement(267795..268298)
/locus_tag="BCG_0238c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976336.1"
/db_xref="GI:121636113"
/db_xref="GeneID:4696741"
/translation="MTLAAEPHPAPPQQPTVAWSEPDVDRRVEFWPTVAIRSALESGD
IATWQRIAAALKRDPYGRTARQVEEVLEGIPATGIANAFWEVLDRARTHLDANERAEV
ARQVGLLLDRSGLQRQEFASRIGVTAQDLTAYLDGIVSPSASLMIRMRRLSDRFVRAK
SVRAADS"
gene complement(268295..271195)
/gene="mmpL11"
/locus_tag="BCG_0239c"
/db_xref="GeneID:4696794"
CDS complement(268295..271195)
/gene="mmpL11"
/locus_tag="BCG_0239c"
/codon_start=1
/transl_table=11
/product="transmembrane transport protein mmpL11"
/protein_id="YP_976337.1"
/db_xref="GI:121636114"
/db_xref="GeneID:4696794"
/translation="MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEV
AGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTE
APNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYV
IGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITM
GLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMA
TSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFA
RAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVL
GNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRH
RIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQV
DVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAA
AYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQ
TGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATV
VRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPP
SADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWG
QRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDR
LQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPG
RQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR"
misc_feature complement(268502..271195)
/gene="mmpL11"
/locus_tag="BCG_0239c"
/note="Predicted drug exporters of the RND superfamily
[General function prediction only]; Region: COG2409"
/db_xref="CDD:225272"
misc_feature complement(<269159..269548)
/gene="mmpL11"
/locus_tag="BCG_0239c"
/note="Sterol-sensing domain of SREBP cleavage-activation;
Region: Sterol-sensing; pfam12349"
/db_xref="CDD:192997"
gene 271417..271827
/locus_tag="BCG_0240"
/db_xref="GeneID:4697541"
CDS 271417..271827
/locus_tag="BCG_0240"
/note="Differs from Rv0203 and Mb0209 by 1aa, T88K"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976338.1"
/db_xref="GI:121636115"
/db_xref="GeneID:4697541"
/translation="MKTGTATTRRRLLAVLIALALPGAAVALLAEPSATGASDPCAAS
EVARTVGSVAKSMGDYLDSHPETNQVMTAVLQQQVGPGSVASLTAHFEANPKVASDLH
ALSQPLTDLSTRCSLPISGLQAIGLMQAVQGARR"
gene complement(271879..273162)
/locus_tag="BCG_0241c"
/db_xref="GeneID:4696793"
CDS complement(271879..273162)
/locus_tag="BCG_0241c"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, the presence of a more likely start
codon leads to a longer product compared to its homolog in
Mycobacterium tuberculosis strain H37Rv (427 a versus 412
aa). Differs from Rv0204c by 1aa, L321V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976339.1"
/db_xref="GI:121636116"
/db_xref="GeneID:4696793"
/translation="MYRDYGATCTVTLKHVSHDAPARNLRQRVGALPRTRVGAPPAEG
VPPRGKYWWLRWAVLAIVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGAS
MHSFAQIQRTLLKSAGVHVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGA
STVVASWQLVMSGVLQAVGLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVA
SRPELIEGIGRRVLSWANSVRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLF
NWIADVACLGFAAYAAGDHASVGGLAVAYAAARAVGTIPLMPGGLLVVEAVLVPGLVS
SGMPLPSAISAMLIYRLISWLLIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLV
IQPQGTPCDDPVETTPQGPAPTPDLRPEGGETPPR"
misc_feature complement(272026..272943)
/locus_tag="BCG_0241c"
/note="Predicted integral membrane protein [Function
unknown]; Region: COG0392"
/db_xref="CDD:223469"
gene 273287..274390
/locus_tag="BCG_0242"
/db_xref="GeneID:4697022"
CDS 273287..274390
/locus_tag="BCG_0242"
/note="Differs from Rv0205 by 1aa, R72H"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976340.1"
/db_xref="GI:121636117"
/db_xref="GeneID:4697022"
/translation="MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNKFEVI
VVPVLLALMLSALLVPPVDWLDSRGLPRAVAVTLVLLSGFAVLGGILTFVVSQFIAGL
PHLVTEVERSIDSARRWLIEGPAHLRGEQIDNAGNAAIEALRNNQAKLTSGALSTAAT
ITELVTAAVLVLFTLIFFLYGGRSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARA
TFLVALTDAAGVGAGLAVMGVPLALPLASLVFFGAFIPLIGAVVAGFLAVVVALLAKG
IGYALITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGALLAV
PTAAFFNNAVQVLLGGNPFADVADVSSDHLTEV"
misc_feature 273347..274219
/locus_tag="BCG_0242"
/note="Domain of unknown function DUF20; Region: UPF0118;
pfam01594"
/db_xref="CDD:201878"
gene complement(274387..277221)
/gene="mmpL3"
/locus_tag="BCG_0243c"
/db_xref="GeneID:4697222"
CDS complement(274387..277221)
/gene="mmpL3"
/locus_tag="BCG_0243c"
/note="Differs from Rv0206c by 2aa, I384F, E466D"
/codon_start=1
/transl_table=11
/product="transmembrane transport protein mmpL3"
/protein_id="YP_976341.1"
/db_xref="GI:121636118"
/db_xref="GeneID:4697222"
/translation="MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFY
DDGSQSVQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQDHP
DQVLGWAGYLRASQATGMATADKKYTFVSIPLKGDDDDTILNNYKAIAPDLQRLDGGT
VKLAGLQPVAEALTGTIATDQRRMEVLALPLVAVVLFFVFGGVIAAGLPVMVGGLCIA
GALGIMRFLAIFGPVHYFAQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRR
TVITAGRTVTFSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLG
ILGKHVDALGVRTLFRVPFLANWKISAAYLNWLADRLQRTKTREEVEAGIWGKLVNRV
MKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPTNSVRQAQEEFDKLFPGYRTN
PLTLVIQTSNHQPVTEAQIADIRSKAMAIGGFIEPDNDPANMWQERAYAVGASKDPSV
RVLQNGLINPADASKKLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVIL
LTTTIVLMFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLTA
PVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRIITAAALIVA
VVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVMKLLGDDCWWAPRWARRL
QTRIGLGEIHLPDERKRPVSNGRPARPPVTAGLVAARAAGDPRPPHDPTHPLAESPRP
ARSSPASSPELTPALEATAAPAAPSGASTTRMQIGSSTEPPTTRLAAAGRSVQSPAST
PPPTPTPPSAPSAGQTRAMPLAANRSTDAAGDPAEPTAALPIIRSDGDDSEAATEQLN
ARGTSDKTRQRRRGGGALSAQDLLRREGRL"
misc_feature complement(276208..277089)
/gene="mmpL3"
/locus_tag="BCG_0243c"
/note="MMPL family; Region: MMPL; pfam03176"
/db_xref="CDD:146013"
misc_feature complement(274990..275946)
/gene="mmpL3"
/locus_tag="BCG_0243c"
/note="MMPL family; Region: MMPL; pfam03176"
/db_xref="CDD:146013"
gene complement(277287..278015)
/locus_tag="BCG_0244c"
/db_xref="GeneID:4695521"
CDS complement(277287..278015)
/locus_tag="BCG_0244c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976342.1"
/db_xref="GI:121636119"
/db_xref="GeneID:4695521"
/translation="MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVW
DAPNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNI
APGSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASA
DGQAFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGL
DSLPEQGAWLQPFRPLSSLLTSRV"
misc_feature complement(277413..277898)
/locus_tag="BCG_0244c"
/note="LabA_like proteins; Region: LabA_like; cd06167"
/db_xref="CDD:199895"
misc_feature complement(order(277527..277529,277533..277535,
277539..277541,277605..277607,277872..277874,
277881..277883))
/locus_tag="BCG_0244c"
/note="putative metal binding site [ion binding]; other
site"
/db_xref="CDD:199895"
gene complement(278018..278809)
/gene="trmB"
/locus_tag="BCG_0245c"
/gene_synonym="yggH"
/db_xref="GeneID:4697253"
CDS complement(278018..278809)
/gene="trmB"
/locus_tag="BCG_0245c"
/gene_synonym="yggH"
/EC_number="2.1.1.33"
/note="tRNA (guanine-N(7)-)-methyltransferase; catalyzes
the formation of N(7)-methylguanine at position 46 (m7G46)
in tRNA by transferring the methyl residue from
S-adenosyl-L-methionine"
/codon_start=1
/transl_table=11
/product="tRNA (guanine-N(7)-)-methyltransferase"
/protein_id="YP_976343.1"
/db_xref="GI:121636120"
/db_xref="GeneID:4697253"
/translation="MVHHGQMHAQPGVGLRPDTPVASGQLPSTSIRSRRSGISKAQRE
TWERLWPELGLLALPQSPRGTPVDTRAWFGRDAPVVLEIGSGSGTSTLAMAKAEPHVD
VIAVDVYRRGLAQLLCAIDKVGSDGINIRLILGNAVDVLQHLIAPDSLCGVRVFFPDP
WPKARHHKRRLLQPATMALIADRLVPSGVLHAATDHPGYAEHIAAAGDAEPRLVRVDP
DTELLPISVVRPATKYERKAQLGGGAVIELLWKKHGCSERDLKIR"
misc_feature complement(278051..278662)
/gene="trmB"
/locus_tag="BCG_0245c"
/gene_synonym="yggH"
/note="Putative methyltransferase; Region: Methyltransf_4;
pfam02390"
/db_xref="CDD:217012"
gene 278941..280026
/locus_tag="BCG_0246"
/db_xref="GeneID:4697234"
CDS 278941..280026
/locus_tag="BCG_0246"
/note="Differs from Rv0209 by 1aa, A162V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976344.1"
/db_xref="GI:121636121"
/db_xref="GeneID:4697234"
/translation="MRGQGHQIFVDELARFATSSADQRVVAIAQRAAEPLRVAVRGRP
GVGCRTVARALQGAGSSSGMTVTPQARAADSDVDLVVYVTVEVVKPEDREAIAATRRP
VVAVLNKADLAGPLSGAGPIVMAQARCAQFSTLLGVPMESMIGLLAVAALDDLDDTLR
AALRALAAHPDGFDALDRAVAGFLAAALPVPTEVRLRLLDTLDLFGIALGMAAFRPGR
PSRTPAQLRTLLRRVSGVDAVIDKVTAAGSEVRYRRLLDAVAELEALAAQAKEIGGPI
GEFLRDDDTVLARMAAAVDVALAVGLDVGPLDDPAAHLPRAVRWHRYSLDNGDMHRTC
GADIARGSLRLWSLAGGMPLHRYRKSS"
gene 280023..281501
/locus_tag="BCG_0247"
/db_xref="GeneID:4699331"
CDS 280023..281501
/locus_tag="BCG_0247"
/note="Differs from Rv0210 by 1aa, T486A"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976345.1"
/db_xref="GI:121636122"
/db_xref="GeneID:4699331"
/translation="MIRAASDDPAGVDELVAAIAPGLAGLGLPVINRREVVLVTGPWL
AGVSGVRAALAERLPQRRFVETAELGPGDAPVAVVFVVSAATALTESDCVLLDTAAEH
TDAVVAVVSKIDVHRGWRDVLTSNRDRLAARASRYARVPWVGAAAAPELGEPYLDDLV
AAIQKQLADPAVARRNMLRAWESRLLMVARRFDGDAQSAGRRARVDALRQQRRTVLRQ
GRQSKSEHTIALRAQIQHARVKLSYFARNRCSLLRVELQEHVAGLSRKDIARFAAYTR
GRVQEVVAEVGEGAVAHLADVAQLLGVPVQPPVLENLPAVLPTVVAPPLTSRRLEIRL
TTLLGAGFGLGIALTLSRLVAGLTPGLAASGMVAGVAIGLAVTAWVVNARALLHDRVV
VDRWTGEVTASLRSVVEQLVATRVVAVETLLSTAISERDDAENARVADQVSIIDGELR
EHAVAAARAAALRDREMPAVRAALEAVRAELGEPGTPTTGLF"
gene 281685..283505
/gene="pckA"
/locus_tag="BCG_0248"
/db_xref="GeneID:4697998"
CDS 281685..283505
/gene="pckA"
/locus_tag="BCG_0248"
/EC_number="4.1.1.32"
/standard_name="pckG; pck1"
/note="catalyzes the phosphorylation and decarboxylation
of oxaloacetate to form phosphoenolpyruvate using GTP"
/codon_start=1
/transl_table=11
/product="phosphoenolpyruvate carboxykinase"
/protein_id="YP_976346.1"
/db_xref="GI:121636123"
/db_xref="GeneID:4697998"
/translation="MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEE
FQRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNW
MDPGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMT
RMGKAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGS
GYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKT
NLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMR
TIAAGNTVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCT
PMSQCPILAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSEQTA
AAEGKVGNVRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDG
RFLWPGFGENSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALA
VDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDALKERLG"
misc_feature 281739..283487
/gene="pckA"
/locus_tag="BCG_0248"
/note="Phosphoenolpyruvate carboxykinase (PEPCK), a
critical gluconeogenic enzyme, catalyzes the first
committed step in the diversion of tricarboxylic acid
cycle intermediates toward gluconeogenesis. It catalyzes
the reversible decarboxylation and...; Region: PEPCK_GTP;
cd00819"
/db_xref="CDD:238417"
misc_feature order(281925..281927,282342..282344,282348..282350,
282366..282371,282429..282431,282495..282515,
282567..282572,282636..282638,282642..282644,
282669..282671,282849..282851,283218..283220,
283227..283229,283236..283238)
/gene="pckA"
/locus_tag="BCG_0248"
/note="active site"
/db_xref="CDD:238417"
misc_feature order(281925..281927,282342..282344,282348..282350,
282366..282371,282636..282638,282849..282851)
/gene="pckA"
/locus_tag="BCG_0248"
/note="substrate-binding site [chemical binding]; other
site"
/db_xref="CDD:238417"
misc_feature order(282369..282371,282429..282431,282510..282512,
282567..282572,282636..282638)
/gene="pckA"
/locus_tag="BCG_0248"
/note="metal-binding site [ion binding]"
/db_xref="CDD:238417"
misc_feature order(282498..282500,282504..282506,282942..282944,
283185..283190,283218..283220,283227..283229,
283236..283238)
/gene="pckA"
/locus_tag="BCG_0248"
/note="GTP binding site [chemical binding]; other site"
/db_xref="CDD:238417"
gene complement(283572..284543)
/gene="nadR"
/locus_tag="BCG_0249c"
/db_xref="GeneID:4698418"
CDS complement(283572..284543)
/gene="nadR"
/locus_tag="BCG_0249c"
/codon_start=1
/transl_table=11
/product="transcriptional regulator NadR"
/protein_id="YP_976347.1"
/db_xref="GI:121636124"
/db_xref="GeneID:4698418"
/translation="MTHGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAEPIP
GAQRVAWMRELFPFDRVVHLANENPQRPWEHPDFWDIWKASLQGVLATRPDFVFGAEP
YNADFAQVLGARFVAVDHGRTVVPVTATDIRADPLGHWQHIPRCVRPAFVKRVSIIGP
ESTGKTTLAQAVAEKLRTKWVPERAKMLRELNGGSLIGLEWAEIVRGQIASEEALARD
ADRVLICDTDPLATTVWAEFLAGGCPQELRDLARRPYDLTLLTTPDVPWDADDGRCVP
GARGTFFARCEQALRAAGRSFVVITGGWEERLSVSLRAVEELVRARR"
misc_feature complement(283620..284543)
/gene="nadR"
/locus_tag="BCG_0249c"
/note="nicotinamide-nucleotide adenylyltransferase, NadR
type; Region: nadR_NMN_Atrans; TIGR01526"
/db_xref="CDD:233448"
misc_feature complement(284100..284537)
/gene="nadR"
/locus_tag="BCG_0249c"
/note="Nicotinamide/nicotinate mononucleotide
adenylyltransferase of bifunctional NadR-like proteins;
Region: NMNAT_NadR; cd02167"
/db_xref="CDD:173918"
misc_feature complement(order(284163..284165,284169..284171,
284241..284249,284298..284300,284307..284315,
284319..284330,284343..284345,284421..284423,
284436..284438,284484..284486,284493..284495,
284502..284504,284514..284525))
/gene="nadR"
/locus_tag="BCG_0249c"
/note="active site"
/db_xref="CDD:173918"
misc_feature complement(284493..284504)
/gene="nadR"
/locus_tag="BCG_0249c"
/note="(T/H)XGH motif; other site"
/db_xref="CDD:173918"
misc_feature complement(283575..284111)
/gene="nadR"
/locus_tag="BCG_0249c"
/note="Predicted ATPase/kinase involved in NAD metabolism
[Coenzyme metabolism]; Region: NadR; COG3172"
/db_xref="CDD:225713"
gene complement(284540..285853)
/locus_tag="BCG_0250c"
/db_xref="GeneID:4696616"
CDS complement(284540..285853)
/locus_tag="BCG_0250c"
/EC_number="2.1.1.-"
/codon_start=1
/transl_table=11
/product="methyltransferase"
/protein_id="YP_976348.1"
/db_xref="GI:121636125"
/db_xref="GeneID:4696616"
/translation="MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTP
RLVGFSCIDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD
GEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVL
ADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNF
LSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGL
RRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDE
LRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEAS
RVYADVVAKVAPDVGISFDEAEAYFLSRLDEWENVIAGRIAEATS"
misc_feature complement(285461..285775)
/locus_tag="BCG_0250c"
/note="B12 binding domain_like associated with radical SAM
domain. This domain shows similarity with B12
(adenosylcobamide) binding domains found in several
enzymes, such as glutamate mutase, methionine synthase and
methylmalonyl-CoA mutase, but it lacks the...; Region:
radical_SAM_B12_BD; cd02068"
/db_xref="CDD:30206"
misc_feature complement(284717..285364)
/locus_tag="BCG_0250c"
/note="Elongator protein 3, MiaB family, Radical SAM;
Region: Elp3; smart00729"
/db_xref="CDD:197846"
misc_feature complement(284732..285343)
/locus_tag="BCG_0250c"
/note="Radical SAM superfamily. Enzymes of this family
generate radicals by combining a 4Fe-4S cluster and
S-adenosylmethionine (SAM) in close proximity. They are
characterized by a conserved CxxxCxxC motif, which
coordinates the conserved iron-sulfur cluster; Region:
Radical_SAM; cd01335"
/db_xref="CDD:100105"
misc_feature complement(order(284783..284788,284882..284884,
285008..285010,285098..285106,285182..285187,
285191..285193,285308..285316,285320..285322,
285326..285328,285332..285334))
/locus_tag="BCG_0250c"
/note="FeS/SAM binding site; other site"
/db_xref="CDD:100105"
gene 285967..287580
/gene="fadD4"
/locus_tag="BCG_0251"
/db_xref="GeneID:4697727"
CDS 285967..287580
/gene="fadD4"
/locus_tag="BCG_0251"
/EC_number="2.3.1.86"
/note="activates fatty acids by binding to coenzyme A"
/codon_start=1
/transl_table=11
/product="long-chain-fatty-acid--CoA ligase"
/protein_id="YP_976349.1"
/db_xref="GI:121636126"
/db_xref="GeneID:4697727"
/translation="MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIAADKP
AVILYPSGTVISFDELEARANRLAHWFRQAGLREDDVVAILMENNEHVHAVMWAARRS
GLYYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGG
GLVGWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMM
PALLDFWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYR
VTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIHAAAPCPVQIKEQMIHWWGPIIDE
YYASSEASGSTLITAEDWLTHPGSVGKPIQGGVHIVGADGSELPPNQPGEIYFEGGYP
FEYLNDPAKTAASRNKHGWVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAEN
LLVAHPKVLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKC
PRSIAFEPQLPRTDTGKLYKSGLVEKYSV"
misc_feature 286096..287571
/gene="fadD4"
/locus_tag="BCG_0251"
/note="long-chain-fatty-acid--CoA ligase; Validated;
Region: PRK08276"
/db_xref="CDD:181347"
misc_feature 286120..>286911
/gene="fadD4"
/locus_tag="BCG_0251"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:213459"
misc_feature 286528..287559
/gene="fadD4"
/locus_tag="BCG_0251"
/note="Bacterial Bile acid CoA ligases and similar
proteins; Region: BACL_like; cd05929"
/db_xref="CDD:213295"
misc_feature order(286531..286533,286540..286557,286561..286566)
/gene="fadD4"
/locus_tag="BCG_0251"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213295"
misc_feature order(286531..286533,286540..286557,286561..286566)
/gene="fadD4"
/locus_tag="BCG_0251"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213270"
misc_feature order(286540..286542,286900..286905,286966..286983,
287212..287214,287248..287250,287257..287259,
287290..287292,287539..287541)
/gene="fadD4"
/locus_tag="BCG_0251"
/note="putative AMP binding site [chemical binding]; other
site"
/db_xref="CDD:213295"
misc_feature order(286540..286542,286672..286677,286813..286815,
286819..286824,286831..286833,286900..286905,
286966..286983,287212..287214,287248..287250,
287257..287259,287281..287292,287482..287484)
/gene="fadD4"
/locus_tag="BCG_0251"
/note="putative active site [active]"
/db_xref="CDD:213295"
misc_feature order(286672..286674,286819..286824,286831..286833,
286900..286902,287281..287289,287464..287466,
287482..287484)
/gene="fadD4"
/locus_tag="BCG_0251"
/note="putative CoA binding site [chemical binding]; other
site"
/db_xref="CDD:213295"
gene complement(287622..288788)
/gene="fadE3"
/locus_tag="BCG_0252c"
/db_xref="GeneID:4696271"
CDS complement(287622..288788)
/gene="fadE3"
/locus_tag="BCG_0252c"
/EC_number="1.3.99.-"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a 29 bp insertion leads to a longer
product compared to its homolog in Mycobacterium
tuberculosis strain H37Rv (388 aa versus 357 aa). Differs
from Mb0221c by 1aa, S361A"
/codon_start=1
/transl_table=11
/product="acyl-CoA dehydrogenase fadE3"
/protein_id="YP_976350.1"
/db_xref="GI:121636127"
/db_xref="GeneID:4696271"
/translation="MRNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEAWIEQ
MKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGHTVVAKLLTLFGT
EEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTALADGPEGSAGLLINGCKTWI
SNARRSGLFAVLCKTDPNATPRHQGMSIVLVEPGPGLTVSRDLPKLGYKGVESCELSF
DNLRVPVSAILGGAMGQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQRESF
GRPIWQHQAVGNYLADMATKLTAARQLTRYAAERYDSGQRCDMEAGMAKLFASEVAME
IALNAVRIHGGYGYSTEYDVERYFRDSPLMILGEGTNEIQRNVIAGQLVARGGI"
misc_feature complement(287628..288788)
/gene="fadE3"
/locus_tag="BCG_0252c"
/note="Acyl-CoA dehydrogenases [Lipid metabolism]; Region:
CaiA; COG1960"
/db_xref="CDD:32143"
misc_feature complement(287643..288770)
/gene="fadE3"
/locus_tag="BCG_0252c"
/note="Acyl-CoA dehydrogenase; Region: ACAD; cl09933"
/db_xref="CDD:209100"
misc_feature complement(order(287673..287675,287679..287681,
287685..287693,288306..288308,288312..288314,
288417..288419,288423..288425,288513..288515))
/gene="fadE3"
/locus_tag="BCG_0252c"
/note="active site"
/db_xref="CDD:173838"
gene 288845..289858
/locus_tag="BCG_0253"
/db_xref="GeneID:4697579"
CDS 288845..289858
/locus_tag="BCG_0253"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976351.1"
/db_xref="GI:121636128"
/db_xref="GeneID:4697579"
/translation="MASGYGGIRVGGPYFDDLSKGQVFDWAPGVTLSLGLAAAHQSIV
GNRLRLALDSDLCAAVTGMPGPLAHPGLVCDVAIGQSTLATQRVKANLFYRGLRFHRF
PAVGDTLYTRTEVVGLRANSPKPGRAPTGLAGLRMTTIDRTDRLVLDFYRCAMLPASP
DWKPGAVPGDDLSRIGADAPAPAADPTAHWDGAVFRKRVPGPHFDAGIAGAVLHSTAD
LVSGAPELARLTLNIAATHHDWRVSGRRLVYGGHTIGLALAQATRLLPNLATVLDWES
CDHTAPVHEGDTLYSELHIESAQAHADGGVLGLRSLVYAVSDSASEPDRQVLDWRFSA
LQF"
misc_feature 288878..289324
/locus_tag="BCG_0253"
/note="FkbR2 is a Streptomyces hygroscopicus protein with
a hot dog fold that belongs to a conserved family of
proteins found in prokaryotes and archaea but not in
eukaryotes. FkbR2 has sequence similarity to (R)-specific
enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2;
cd03451"
/db_xref="CDD:239535"
misc_feature order(288965..288967,288980..288982,288986..288988,
288995..288997,289043..289045,289052..289057)
/locus_tag="BCG_0253"
/note="putative active site [active]"
/db_xref="CDD:239535"
misc_feature order(288980..288982,288986..288988,288995..288997,
289052..289054)
/locus_tag="BCG_0253"
/note="putative catalytic site [active]"
/db_xref="CDD:239535"
misc_feature 289418..289846
/locus_tag="BCG_0253"
/note="The hotdog fold was initially identified in the E.
coli FabA (beta-hydroxydecanoyl-acyl carrier protein
(ACP)-dehydratase) structure and subsequently in 4HBT
(4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A
number of other seemingly unrelated...; Region: hot_dog;
cl00509"
/db_xref="CDD:241913"
misc_feature order(289589..289594,289679..289690)
/locus_tag="BCG_0253"
/note="active site 2 [active]"
/db_xref="CDD:239524"
misc_feature order(289607..289609,289616..289621,289628..289630,
289655..289663)
/locus_tag="BCG_0253"
/note="active site 1 [active]"
/db_xref="CDD:239524"
gene complement(289855..290763)
/gene="lipW"
/locus_tag="BCG_0254c"
/db_xref="GeneID:4698090"
CDS complement(289855..290763)
/gene="lipW"
/locus_tag="BCG_0254c"
/EC_number="3.1.1.-"
/note="Differs from Rv0217c by 1aa T184P"
/codon_start=1
/transl_table=11
/product="esterase lipW"
/protein_id="YP_976352.1"
/db_xref="GI:121636129"
/db_xref="GeneID:4698090"
/translation="MSGNEVHPDLRRIAVVTPRQLVGPRTLPVMRALIVVAGLRMSRT
PPDIEVLTLESGVGVRLYRPAGSNEPAPALLWIHAGGYVMGTAQQDDRLCLRFSSRLG
ITVASVDYRLAPENPYPAALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALAL
LARDRGGITPAFQLLVYPMLDDRTSIAPANPHYRLWNGRANRFGWRAYLGDADARVAV
PGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVEGAFHGFDRVAP
NVGVSQRFFTSQCNSLRAALALSNRT"
misc_feature complement(<290422..290583)
/gene="lipW"
/locus_tag="BCG_0254c"
/note="Esterases and lipases (includes fungal lipases,
cholinesterases, etc.) These enzymes act on carboxylic
esters (EC: 3.1.1.-). The catalytic apparatus involves
three residues (catalytic triad): a serine, a glutamate or
aspartate and a histidine.These...; Region:
Esterase_lipase; cd00312"
/db_xref="CDD:238191"
misc_feature complement(289951..290544)
/gene="lipW"
/locus_tag="BCG_0254c"
/note="alpha/beta hydrolase fold; Region: Abhydrolase_3;
pfam07859"
/db_xref="CDD:219611"
gene 290856..292184
/locus_tag="BCG_0255"
/db_xref="GeneID:4695784"
CDS 290856..292184
/locus_tag="BCG_0255"
/note="Differs from Rv0218 by 2aa, R316C, N413D"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976353.1"
/db_xref="GI:121636130"
/db_xref="GeneID:4695784"
/translation="MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRG
PWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRPSWL
YRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQ
IVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLG
TNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKA
ALLLPRGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLRGGPAEVVLDRATLAGLPQ
RTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAARSARVTSLQRGGAFGEAKLAAN
QIADPDALLALRVDGADLSLNHGYPARIIVPALPGVHNTKWVAGIEFHKR"
misc_feature 290988..>291587
/locus_tag="BCG_0255"
/note="Sulfite oxidase and related enzymes [General
function prediction only]; Region: COG2041"
/db_xref="CDD:32224"
misc_feature 291783..292181
/locus_tag="BCG_0255"
/note="Sulfite oxidase (SO) family, molybdopterin binding
domain. This molybdopterin cofactor (Moco) binding domain
is found in a variety of oxidoreductases, main members of
this family are nitrate reductase (NR) and sulfite oxidase
(SO). SO catalyzes the...; Region: SO_family_Moco;
cd00321"
/db_xref="CDD:29401"
misc_feature <291786..292172
/locus_tag="BCG_0255"
/note="Sulfite oxidase and related enzymes [General
function prediction only]; Region: COG2041"
/db_xref="CDD:32224"
misc_feature order(291882..291884,292095..292097,292110..292112,
292134..292136,292143..292145,292149..292154)
/locus_tag="BCG_0255"
/note="Moco binding site; other site"
/db_xref="CDD:29401"
misc_feature 291882..291884
/locus_tag="BCG_0255"
/note="metal coordination site [ion binding]; other site"
/db_xref="CDD:29401"
gene 292186..292734
/locus_tag="BCG_0256"
/db_xref="GeneID:4697761"
CDS 292186..292734
/locus_tag="BCG_0256"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976354.1"
/db_xref="GI:121636131"
/db_xref="GeneID:4697761"
/translation="MFDIATRFKNSYGSGPLHLLAMVSGFALLGYIVATARPSALWNQ
ATWWQSIAVWFVAAVVAHDLLLYPLYALADRILARLVGRRDVSAPRRRPELPVRNYIR
IPALAAGLTLLVFLPGIIRQGAPTYLDATGQTQEPFLGRWLLLTAVAFGISAAAYAIR
LVVAHVRRRRAGCSRVDAIDEE"
gene 292744..293985
/gene="lipC"
/locus_tag="BCG_0257"
/db_xref="GeneID:4699256"
CDS 292744..293985
/gene="lipC"
/locus_tag="BCG_0257"
/EC_number="3.1.1.-"
/codon_start=1
/transl_table=11
/product="esterase lipC"
/protein_id="YP_976355.1"
/db_xref="GI:121636132"
/db_xref="GeneID:4699256"
/translation="MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHL
KPLGGVTAIGVWGARHASDFLSATAKDLLTPGINEVRRRDRASTQEVSVAALRGIVSP
DDLAVEWPAPERTPPVCGALRHRRYVHRRRVLYGDDPAQLLDVWRRKDMPTKPAPVLI
FVPGGAWVHGSRAIQGYAVLSRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWAR
ANVDKFGGDRNFIAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGR
YDWEDRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPFLVIHGSRD
CVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTGPTAHAIALFLNQVH
RSRAQFAKEVIQTPANCMVAL"
misc_feature 293218..293856
/gene="lipC"
/locus_tag="BCG_0257"
/note="alpha/beta hydrolase fold; Region: Abhydrolase_3;
pfam07859"
/db_xref="CDD:203783"
misc_feature 293290..293850
/gene="lipC"
/locus_tag="BCG_0257"
/note="Esterases and lipases (includes fungal lipases,
cholinesterases, etc.) These enzymes act on carboxylic
esters (EC: 3.1.1.-). The catalytic apparatus involves
three residues (catalytic triad): a serine, a glutamate or
aspartate and a histidine.These...; Region:
Esterase_lipase; cl12031"
/db_xref="CDD:214205"
gene 293999..294772
/locus_tag="BCG_0258"
/db_xref="GeneID:4698688"
CDS 293999..294772
/locus_tag="BCG_0258"
/note="In Mycobacterium bovis and Mycobacterium bovis BCG
Pasteur, RD10, a 1902 bp deletion leads to a shorter
product with a different COOH part, compared to its
homolog in Mycobacterium tuberculosis strain H37Rv (257 aa
versus 469 aa). It also leads to the deletion of the next
protein, echA1 (Rv0222)"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976356.1"
/db_xref="GI:121636133"
/db_xref="GeneID:4698688"
/translation="MKRLSGWDAVLLYSETPNVHMHTLKVAVIELDSDRQEFGVDAFR
EVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRPWRLRAPGGRRELDEA
VGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIHHALADGVASANMMARGMDLLPG
PEVGRYVPDPAPTKRQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLSPALT
MPFTPPPTFMNRIKKPLSKPSGRPPPHTNRAPSSMPLAM"
misc_feature 294008..294634
/locus_tag="BCG_0258"
/note="Wax ester synthase-like Acyl-CoA acyltransferase
domain; Region: WES_acyltransf; pfam03007"
/db_xref="CDD:111851"
gene complement(294638..295447)
/locus_tag="BCG_0259c"
/db_xref="GeneID:4698049"
CDS complement(294638..295447)
/locus_tag="BCG_0259c"
/EC_number="1.2.1.-"
/note="In mycobacterium bovis strain AF2122/97 and
Mycobacterium bovis BCG Pasteur, RD10, a 1902 bp deletion,
compared to Mycobacterium tuberculosis H37Rv, truncates
Rv0221c and Rv0223c and removes Rv0222c;
In Mycobacterium bovis BCG Pasteur, a single base deletion
at position equivalent to Mycobacterium tuberculosis
H37Rv2 267419-267419(*-c) splits gene into two parts
compared to its homologs in Mycobacterium tuberculosis
strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and
269 aa, versus 487 aa and 385 aa, respectively. Also has
same 1 bp insertion, as Mycobacterium bovis AF2122/97, at
position equivalent to Mycobacterium tuberculosis H37Rv2
base 266743. Deletion in Mycobacterium bovis and bovis BCG
Pasteur of region RD10 leads to a different COOH part
compared to Mycobacterium tuberculosis strain H37Rv. May
be pseudogene"
/codon_start=1
/transl_table=11
/product="aldehyde dehydrogenase"
/protein_id="YP_976357.1"
/db_xref="GI:121636134"
/db_xref="GeneID:4698049"
/translation="MNYFAGAADKVTWTETRTGSYGQSIVSRESVGVVGAIVAWNVPL
FLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQA
LTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMM
VFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEK
QRTRVEALHRQGHRGGRSVGVRRRPSRGLGQRLLYPIHERRWRGKWHGQCG"
misc_feature complement(<294776..>295447)
/locus_tag="BCG_0259c"
/note="NAD(P)+-dependent aldehyde dehydrogenase
superfamily; Region: ALDH-SF; cl11961"
/db_xref="CDD:213126"
misc_feature complement(order(294932..294934,295028..295036,
295076..295081,295088..295090,295097..295108,
295247..295252,295256..295258,295301..295303,
295325..295339))
/locus_tag="BCG_0259c"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:143395"
misc_feature complement(order(294932..294934,294941..294943,
295034..295036,295325..295327))
/locus_tag="BCG_0259c"
/note="catalytic residues [active]"
/db_xref="CDD:143395"
misc_feature 294686..294687
/locus_tag="BCG_0258"
/note="RD10, 1902 bp. Region of Difference RD10, deleted
region in Mycobacterium bovis BCG Pasteur (position
294686..294687) and Mycobacterium bovis AF2122/97
(position 264979..264980) compared to Mycobacterium
tuberculosis H37Rv2 (position: 264755..266656, 1902bp).
Removes gene Rv0222 and truncates genes Rv0221 and Rv0223"
gene complement(295444..295794)
/locus_tag="BCG_0260c"
/db_xref="GeneID:4698185"
CDS complement(295444..295794)
/locus_tag="BCG_0260c"
/EC_number="1.2.1.-"
/note="In Mycobacterium bovis BCG Pasteur, a single base
deletion at position equivalent to Mycobacterium
tuberculosis H37Rv2 267419-267419(*-c) splits gene into
two parts compared to its homologs in Mycobacterium
tuberculosis strain H37Rv and Mycobacterium bovis
AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa,
respectively. Also has same 1 bp insertion, as
Mycobacterium bovis AF2122/97, at position equivalent to
Mycobacterium tuberculosis H37Rv2 base 266743. May be
pseudogene"
/codon_start=1
/transl_table=11
/product="aldehyde dehydrogenase"
/protein_id="YP_976358.1"
/db_xref="GI:121636135"
/db_xref="GeneID:4698185"
/translation="MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAA
AADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPP
TIIETMHWMGSMGR"
misc_feature complement(<295450..295764)
/locus_tag="BCG_0260c"
/note="NAD(P)+-dependent aldehyde dehydrogenase
superfamily; Region: ALDH-SF; cl11961"
/db_xref="CDD:213126"
gene complement(295893..296657)
/locus_tag="BCG_0261c"
/db_xref="GeneID:4699063"
CDS complement(295893..296657)
/locus_tag="BCG_0261c"
/EC_number="2.1.1.-"
/note="Differs from Rv0224c by 1aa, L117F"
/codon_start=1
/transl_table=11
/product="methyltransferase"
/protein_id="YP_976359.1"
/db_xref="GI:121636136"
/db_xref="GeneID:4699063"
/translation="MAVTDVFARRATLRRSLRLLADFRYEQRDPARFYRTLAADTAAM
IGDLWLATHSEPPVGRTLLDVGGGPGYFATAFSDAGVGYIGVEPDPDEMHAAGPAFTG
RPGMFVRASGMALPLADDSVDICLSSNVAEHVPRPWQLGTEMLRVTKPGGLVVLSYTV
WLGPFGGHEMGLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGA
ALAVFPRYHPRWAWWLTSVPVLREFLVSNLVLVLTP"
misc_feature complement(296175..296477)
/locus_tag="BCG_0261c"
/note="S-adenosylmethionine-dependent methyltransferases
(SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
that use S-adenosyl-L-methionine (SAM or AdoMet) as a
substrate for methyltransfer, creating the product
S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
cd02440"
/db_xref="CDD:100107"
misc_feature complement(order(296274..296276,296322..296330,
296394..296399,296445..296465))
/locus_tag="BCG_0261c"
/note="S-adenosylmethionine binding site [chemical
binding]; other site"
/db_xref="CDD:100107"
gene 296693..297847
/locus_tag="BCG_0262"
/db_xref="GeneID:4699029"
CDS 296693..297847
/locus_tag="BCG_0262"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976360.1"
/db_xref="GI:121636137"
/db_xref="GeneID:4699029"
/translation="MSALRSVLLLCWRDIGHPQGGGSEAYLQRIGAQLAASGIAVTLR
TARYPGAPRHELVDGVRISRAGGRYSVYLWALLAMAAARCGLGPLRRVRPDVVVDTQN
GWPFVARLLYGRRSLVLVHHCHREQWPVAGRMMGRLGWYVESMLSPRLHRRNQYVTVS
LPSARDLIALGVDSERIAVVRNGLDEAPSPTLSGPRAPTPRVVVLSRLVPHKQIEDAL
AAVAELQPRIPGLHLDIVGGGWWRQRLVDHVHRLDIADAVTFHGHVDDVTKHHVLQSS
WVHLLPSRKEGWGLAVIEAAQHGVPTIGYRSSGGLADSIVDGVTGILVDDRAELVAWL
EQLLSDSVLRDQLGAKAQARSGEFSWRQSAEALRSVLEAVQASRFVSGVV"
misc_feature 296711..297808
/locus_tag="BCG_0262"
/note="This family is most closely related to the GT1
family of glycosyltransferases and named after YqgM in
Bacillus licheniformis about which little is known.
Glycosyltransferases catalyze the transfer of sugar
moieties from activated donor molecules to...; Region:
GT1_YqgM_like; cd03801"
/db_xref="CDD:99974"
misc_feature 296717..297826
/locus_tag="BCG_0262"
/note="Glycosyltransferase [Cell envelope biogenesis,
outer membrane]; Region: RfaG; COG0438"
/db_xref="CDD:223515"
gene complement(297864..299594)
/locus_tag="BCG_0263c"
/db_xref="GeneID:4698239"
CDS complement(297864..299594)
/locus_tag="BCG_0263c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976361.1"
/db_xref="GI:121636138"
/db_xref="GeneID:4698239"
/translation="MRWFRPGYALVLVLLLAAPLLRPGYLLLRDAVSTPRSYVSANAL
GLTSAPRATPQDFAVALASHLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAG
QFVAITLAIWNPYVAERLLQGHWSLLVGYGCLPWVATAMLTMRTTVGAGWFGLFGLAF
WVALAGLTPSGLLLAATVAVVCVAMPGAGRPRWQCGVAALGSALVGALPWLTASALGS
SLTSHTAANQLGVTAFAPRAEPGLGTLGSLASLGGIWNGEAVPSSRTTLFAVASAVVL
LAMVAIGLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVLRD
GQKWVALAVPGYTLSGAGTVLTLRRWLRPATAAVVCCLALVLTLPDLAWGVWGKVAPV
HYPSGWAAVAAAINADPRTVAVLPAGTMRRFSWSGSAPVLDPLPRWVRADVLTTGDLV
ISGVTVPGEDAHARAVQELLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRLA
AAHRDDELALYRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLHHC
EDTPASRAQD"
gene complement(299604..300869)
/locus_tag="BCG_0264c"
/db_xref="GeneID:4698794"
CDS complement(299604..300869)
/locus_tag="BCG_0264c"
/note="Differs from Rv0227c by 1aa, R29S, and from Mb0232c
by 1aa, S392N"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976362.1"
/db_xref="GI:121636139"
/db_xref="GeneID:4698794"
/translation="MLRFAACGAIGLGAALLIAALLLSTYTTRRIAEIPLDIDATLIS
DGTGTALDSASLATEHIVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKD
SGLLLAIVDTVTLNRKTAMAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFP
FHTEKKTYPYFDPIAQKAFDANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSL
YAGDEDGKVTTSAAMWGLPGDPNEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYF
ARDPLKPEVTFADYQVTSTEETVESQVNAARDERDRLALWSRVLPITFTAAGLVALVG
GGLFASFSLRTEGALMAASGDRDDHDYRRGGFEEPVPGAEAETEKLPTQRPDFPREPS
GSDPPRLGSAQPPPPPDAGHPDPGPPERR"
misc_feature complement(299895..300797)
/locus_tag="BCG_0264c"
/note="Protein of unknown function (DUF3068); Region:
DUF3068; pfam11271"
/db_xref="CDD:151712"
gene 301085..302308
/locus_tag="BCG_0265"
/db_xref="GeneID:4698221"
CDS 301085..302308
/locus_tag="BCG_0265"
/EC_number="2.3.1.-"
/codon_start=1
/transl_table=11
/product="integral membrane acyltransferase"
/protein_id="YP_976363.1"
/db_xref="GI:121636140"
/db_xref="GeneID:4698221"
/translation="MGPADESGAPIRPQTPHRHTVLVTNGQVVGGTRGFLPAVEGMRA
CAAVGVVVTHVAFQTGHSSGVGGRLFGRFDLAVAVFFAVSGFLLWRGHAAAARDLRSH
PRTGPYLRSRVARIMPAYVVAVVVILSLLPDADHASLTVWLANLTLTQIYVPLTLTGG
LTQMWSLSVEVAFYAALPVLALLGRRIPVGARVPAIAALAALSWAWGWLPLDAGSGIN
PLTWPPAFFSWFAAGMLLAEWAYSPVGLPHRWARRRVAMAVTALLGYLVAASPLAGPE
GLVPGTAAQFAVKTAMGSLVAFALVAPLVLDRPDTSHRLLGSPAMVTLGRWSYGLFIW
HLAALAMVFPVIGAFPFTGRMPTVLVLTLIFGFAIAAVSYALVESPCREALRRWERRN
EPISVGELQADAIAP"
misc_feature 301163..302305
/locus_tag="BCG_0265"
/note="Predicted acyltransferases [Lipid metabolism];
Region: COG1835"
/db_xref="CDD:224748"
gene complement(302336..303016)
/locus_tag="BCG_0266c"
/db_xref="GeneID:4698790"
CDS complement(302336..303016)
/locus_tag="BCG_0266c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976364.1"
/db_xref="GI:121636141"
/db_xref="GeneID:4698790"
/translation="MRQPRRANAMGLALCIYIGSLLIYTPIHGETSRRHRRAGFKHGS
YRIGHDDDQRHRQRGPAASHVSASSTRRRRSRHAGRRTARGPRRSMALKYLLDTSVIK
RLSRPAVRRAVEPLAEAGAVARTQITDLEVGYSARNETEWQRLMVALSAFDLIESTAS
HHRRALGIQRLLAARSQRGRKIPDLLIAAAGEEHGLVVLHYDADFDLIAAVTGQPCQW
IVPAGTID"
misc_feature complement(302363..302734)
/locus_tag="BCG_0266c"
/note="PIN domain of the Rv0301 toxin of Mycobacterium
tuberculosis and other uncharacterized, annotated PilT
protein domain proteins; Region: PIN_MtRv0301; cd09882"
/db_xref="CDD:189052"
misc_feature complement(order(302411..302413,302465..302467,
302624..302626,302726..302728))
/locus_tag="BCG_0266c"
/note="putative active site [active]"
/db_xref="CDD:189052"
gene complement(303013..303993)
/gene="php"
/locus_tag="BCG_0267c"
/db_xref="GeneID:4695383"
CDS complement(303013..303993)
/gene="php"
/locus_tag="BCG_0267c"
/EC_number="3.1.8.1"
/note="Differs from Rv0230c by 1aa, E199D"
/codon_start=1
/transl_table=11
/product="phosphotriesterase PHP"
/protein_id="YP_976365.1"
/db_xref="GI:121636142"
/db_xref="GeneID:4695383"
/translation="MPELNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDED
KRVAGAIARLGELKARGVDTIVDLTVIGLGRYIPRIARVAAATELNIVVATGLYTYND
VPFYFHYLGPGAQLDGPEIMTDMFVRDIEHGIADTGIKAGILKCATDEPGLTPGVERV
LRAVAQAHKRTGAPISTHTHAGLRRGLDQQRIFAEEGVELSRVVIGHCGDSTDVGYLE
ELIAAGSYLGMDRFGVDVISPFQDRVNIVARMCERGHADKMVLSHDACCYFDALPEEL
VPVAMPNWHYLHIHNDVIPALKQHGVTDEQLHTMLVDNPRRIFERQGGYQ"
misc_feature complement(303037..303945)
/gene="php"
/locus_tag="BCG_0267c"
/note="Phosphotriesterase (PTE) catalyzes the hydrolysis
of organophosphate nerve agents, including the chemical
warfare agents VX, soman, and sarin as well as the
insecticide paraoxon. PTE exists as a homodimer with one
active site per monomer. The active site...; Region: PTE;
cd00530"
/db_xref="CDD:238295"
misc_feature complement(order(303202..303204,303373..303375,
303460..303462,303559..303561,303922..303924,
303928..303930))
/gene="php"
/locus_tag="BCG_0267c"
/note="active site"
/db_xref="CDD:238295"
misc_feature complement(order(303202..303204,303460..303462,
303700..303702,303922..303924))
/gene="php"
/locus_tag="BCG_0267c"
/note="substrate binding pocket [chemical binding]; other
site"
/db_xref="CDD:238295"
misc_feature complement(order(303589..303591,303610..303612,
303631..303633,303643..303645,303781..303783,
303907..303909))
/gene="php"
/locus_tag="BCG_0267c"
/note="homodimer interaction site [polypeptide binding];
other site"
/db_xref="CDD:238295"
gene 304088..305794
/gene="fadE4"
/locus_tag="BCG_0268"
/db_xref="GeneID:4697037"
CDS 304088..305794
/gene="fadE4"
/locus_tag="BCG_0268"
/EC_number="1.3.99.-"
/codon_start=1
/transl_table=11
/product="acyl-CoA dehydrogenase fadE4"
/protein_id="YP_976366.1"
/db_xref="GI:121636143"
/db_xref="GeneID:4697037"
/translation="MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHDDHERI
WYSDFLDFVGRERIFASLLTPASYGADDCRWDTYRISEFAEIMGFYGLSYWYPFQVTA
LGLGPIWMSANEDAKRKAAAGLEAGEVFAFGLSEQTHGADVYQTDMILTPSDGGWTAN
GEKYYIGNANVARMVSTFGKIAGTPESQEYVFFVADSQHERYDLIKNVVNSQNYVANY
ALRDYPVTEADILHRGAEAFHAALNTVNVCKYNLGWGAIGMCTHALYESVTHAANRHL
YGTVVTDFSHVRRLLTDAYVRLIAMKLVASRASDYMRSASAADRRYLLYSPLTKAKVT
SEGERVITALWDVIAAKGVEKDTFFETVAREIGLLPRLEGTVHINIGLLGKFMPNYLF
APDSTLPVIPRRDDAADDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQV
DVFAELLASATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFG
VLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVLALNGAYQM
AP"
misc_feature 304139..305248
/gene="fadE4"
/locus_tag="BCG_0268"
/note="Acyl-CoA dehydrogenases [Lipid metabolism]; Region:
CaiA; COG1960"
/db_xref="CDD:224871"
misc_feature 304394..305242
/gene="fadE4"
/locus_tag="BCG_0268"
/note="Acyl-CoA dehydrogenase; Region: ACAD; cd00567"
/db_xref="CDD:173838"
misc_feature order(304394..304396,304481..304483,304487..304489,
304580..304582,304586..304588,305198..305206,
305210..305212,305216..305218)
/gene="fadE4"
/locus_tag="BCG_0268"
/note="active site"
/db_xref="CDD:173838"
gene 305929..306618
/locus_tag="BCG_0269"
/db_xref="GeneID:4696255"
CDS 305929..306618
/locus_tag="BCG_0269"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976367.1"
/db_xref="GI:121636144"
/db_xref="GeneID:4696255"
/translation="MPTVTWARVDPARRAAVVEAAEAEFGAHGFSRGSLNVIARRAGV
AKGSLFQYFADKRDLYAFIADIASQRVRSYMEDLIRELDPNRPFFEFLTDLLDGWVAY
FAEHPRERALHAAATLEVDTDARISVRSVLHRHYLDVLRPLVRDAHARGDLRADSDTG
ALMSLLLLIFPHLALAPYMRGLDPILGLDEPTPEQPALAVRRLVAVLAAAFDAQHPAT
NSAQTRSEEIT"
misc_feature 306001..>306396
/locus_tag="BCG_0269"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature 306001..306111
/locus_tag="BCG_0269"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 306615..307559
/gene="nrdB"
/locus_tag="BCG_0270"
/db_xref="GeneID:4695750"
CDS 306615..307559
/gene="nrdB"
/locus_tag="BCG_0270"
/EC_number="1.17.4.1"
/note="Catalyzes the rate-limiting step in dNTP synthesis"
/codon_start=1
/transl_table=11
/product="ribonucleotide-diphosphate reductase subunit
beta"
/protein_id="YP_976368.1"
/db_xref="GI:121636145"
/db_xref="GeneID:4695750"
/translation="MTRTRSGSLAAGGLNWASLPLKLFAGGNAKFWDPADIDFTRDRA
DWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSAMRAEGRLADEMYLTQFAFEEA
KHTQVFRMWLDAVGISEDLHRYLDDLPAYRQIFYAELPECLNALSADPSPAAQVRASV
TYNHIVEGMLALTGYYAWHKICVERAILPGMQELVRRIGDDERRHMAWGTFTCRRHVA
ADDANWTVFETRMNELIPLALRLIEEGFALYGDQPPFDLSKDDFLQYSTDKGMRRFGT
ISNARGRPVAEIDVDYSPAQLEDTFADEDRRTLAAASA"
misc_feature 306648..307493
/gene="nrdB"
/locus_tag="BCG_0270"
/note="Ribonucleotide Reductase R2-like protein,
Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911"
/db_xref="CDD:153120"
misc_feature order(306780..306782,306804..306806,306816..306818,
306825..306827,306903..306905,306915..306917,
306924..306926,307017..307019,307110..307115,
307125..307127,307134..307136,307143..307145,
307218..307220,307227..307229,307335..307337,
307350..307352,307398..307400)
/gene="nrdB"
/locus_tag="BCG_0270"
/note="active site"
/db_xref="CDD:153120"
misc_feature order(306816..306818,306915..306917,306924..306926,
307113..307115,307137..307139,307218..307220,
307227..307229)
/gene="nrdB"
/locus_tag="BCG_0270"
/note="diiron metal binding site [ion binding]; other
site"
/db_xref="CDD:153120"
gene complement(307635..309170)
/gene="gabD1"
/locus_tag="BCG_0271c"
/db_xref="GeneID:4698713"
CDS complement(307635..309170)
/gene="gabD1"
/locus_tag="BCG_0271c"
/EC_number="1.2.1.16"
/standard_name="gabD2"
/note="NADP-dependent semialdehyde dehydrogenase; part of
alternative pathway from alpha-ketoglutarate to succinate"
/codon_start=1
/transl_table=11
/product="succinate-semialdehyde dehydrogenase"
/protein_id="YP_976369.1"
/db_xref="GI:121636146"
/db_xref="GeneID:4698713"
/translation="MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRF
VQTHPAKDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRA
RWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEP
ADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQ
CALYLADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAG
NEIKPTVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDD
FVDKFVARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLD
RPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGSNAWT
RDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSAHGIREFCNIKTV
WIA"
misc_feature complement(<308862..309047)
/gene="gabD1"
/locus_tag="BCG_0271c"
/note="NAD(P)+-dependent aldehyde dehydrogenase
superfamily; Region: ALDH-SF; cl11961"
/db_xref="CDD:245815"
misc_feature complement(307641..309002)
/gene="gabD1"
/locus_tag="BCG_0271c"
/note="NAD-dependent aldehyde dehydrogenases [Energy
production and conversion]; Region: PutA; COG1012"
/db_xref="CDD:223944"
misc_feature complement(307641..308936)
/gene="gabD1"
/locus_tag="BCG_0271c"
/note="Mycobacterium tuberculosis succinate-semialdehyde
dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100"
/db_xref="CDD:143418"
misc_feature complement(order(307725..307727,307839..307841,
307917..307919,307923..307925,308214..308216,
308310..308318,308358..308363,308370..308372,
308379..308390,308529..308534,308538..308540,
308583..308585,308607..308621))
/gene="gabD1"
/locus_tag="BCG_0271c"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:143418"
misc_feature complement(order(308214..308216,308223..308225,
308316..308318,308607..308609))
/gene="gabD1"
/locus_tag="BCG_0271c"
/note="catalytic residues [active]"
/db_xref="CDD:143418"
gene complement(309196..310644)
/locus_tag="BCG_0272c"
/db_xref="GeneID:4695548"
CDS complement(309196..310644)
/locus_tag="BCG_0272c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976370.1"
/db_xref="GI:121636147"
/db_xref="GeneID:4695548"
/translation="MGWFSAPEYWLGRLALERGTAIIYLIAFVAAAQQFRPLIGEHGM
LPVPRYLAGQSFWRTPSIFHFRYSDRVFAGVCWLGAVLSAAVVAGAASFVPLWATMLI
WLTLWVLYLSIVNVGQAWYSFGWESLLLETGFLMIFLGNERTAPPILTLLLARWLLFR
VEFGAGLIKMRGDSCWRSLTCLYYHHETQPMPGPLSWFFHHLPKPLHRIEVAGNHFAQ
LVVPFGLFTPQPAASIAAAIIVVTQLWLVASGNFSWLNWLTILLACSAIDTSSAAALL
PMPAQPALSAPPQWFAGLVVVFTAAVLLLSYWPARNLLSSHQRMNMSFNPFHLVNTYG
AFGSICRTRREVVIEGTDESPITEQTVWKAYEFKGKPGDPRRLPRQWAPYHLRLDWLM
WFAAISPGYALPWMTPFLNRLLRNDPATLKLLRHNPFPQSPPRYVRAQLYQYRFTTVA
ELRRDRAWWHRTLIGRYVPPMSLRKVASPPAD"
misc_feature complement(309223..310284)
/locus_tag="BCG_0272c"
/note="Lipase maturation factor; Region: LMF1; pfam06762"
/db_xref="CDD:219165"
gene complement(310679..314881)
/locus_tag="BCG_0273c"
/db_xref="GeneID:4698499"
CDS complement(310679..314881)
/locus_tag="BCG_0273c"
/note="Differs from Rv0236c by 3aa, V412M, A990T, G1080S"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976371.1"
/db_xref="GI:121636148"
/db_xref="GeneID:4698499"
/translation="MAPLSRKWLPVVGAVALALTFAQSPGQVSPDTKLDLTANPLRFL
ARATNLWNSDLPFGQAQNQAYGYLFPHGTFFVIGHLLGVPGWVTQRLWWAVLLTVGFW
GLLRVAEALGVGGPSSRVVGAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILAL
RGTSGRSVRALAAQAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRLWWRYTAWWL
LAMALATLWWVMALTQLHGVSPPFLDFIESSGVTTQWSSLVEVLRGTDSWTPFVAPNA
TAGAPLVTGSAAILGTCLVAAAGLAGLTSPAMPARGRLVTMLLVGVVLLAVGHRGGLA
SPVAHPVQAFLDAAGTPLRNVHKVGPVIRLPLVLGLAQLLSRVPLPGSAPRPAWLRAF
AHPERDKRVAVAVVALTALVVSTSLAWTGRVAPPGTFGALPQYWQEAADWLRTHHAAT
PTPGRVLVVPGAPFATQVWGTSHDEPLQVLGDGPWGVRDSIPLTPPQTIRALDSVQRL
FAAGRPSAGLADTLARQGISYVLVRNDLDPETSRSARPILLHRSIAGSPGLAKLAEFG
APVGPDPLAGFVNDSGLRPRYPAIEIYRVSAPANPGAPYFAATDQLARVDGGPEVLLR
LDERRRLQGQPPLGPVLMTADARAAGLPVPQVAVTDTPVARETDYGRVDHHSSAIRAP
GDARHTYNRVPDYPVPGAEPVVGGWTGGRITVSSSSADATAMPDVAPASAPAAAVDGD
PATAWVSNALQAAVGQWLQVDFDRPVTNAVVTLTPSATAVGAQVRRILIETVNGSTTL
RFDEAGKPLTAALPYGETPWVRFTAAATDDGSAGVQFGITDLAITQYDASGFAHPVQL
RHTVLVPGPPPGSAIAGWDLGSELLGRPGCAPGPDGVRCAASMALAPEEPANLSRTLT
VPRPVSVTPMVWVRPRQGPKLADLIAAPSTTRASGDSDLVDILGSAYAAADGDPATAW
TAPQRVVQHKTPPTLTLALPRPTVVTGLRLAASRSMLPAHPTVVAINLGDGPQVRQLQ
VGELTTLWLHPRVTDTVSVSLLDWDDVIDRNALGFDQLKPPGLAEVVVLGAGGAPIAP
ADAARNRARALTVDCDHGPVVAVAGRFVHTSIRTTVGALLDGEPVAALPCEREPIALP
AGQQELLISPGAAFVVDGAQLSTPGAGLSSATVTSAETGAWGPTHREVRVPESATSRV
LVVPESINSGWVARTSTGARLTPIAVNGWQQAWVVPAGNPGTITLTFAPNSLYRASLA
IGLALLPLLALLAFWRTGRRQLADRPTPPWRPGAWAAAGVLAAGAVIASIAGVMVMGT
ALGVRYALRRRERLRDRVTVGLAAGGLILAGAALSRHPWRSVDGYAGNWASVQLLALI
SVSVVAASVVATSESRGQDRMQ"
misc_feature complement(312800..314842)
/locus_tag="BCG_0273c"
/note="Domain of unknown function (DUF3367); Region:
DUF3367; pfam11847"
/db_xref="CDD:152283"
gene complement(314928..315101)
/locus_tag="BCG_0274c"
/db_xref="GeneID:4698021"
CDS complement(314928..315101)
/locus_tag="BCG_0274c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976372.1"
/db_xref="GI:121636149"
/db_xref="GeneID:4698021"
/translation="MNRIVAPAAASVVVGLLLGAAAIFGVTLMVQQDKKPPLPGGDPS
SSVLNRVEYGNRS"
misc_feature complement(314934..315101)
/locus_tag="BCG_0274c"
/note="Protein of unknown function (DUF2613); Region:
DUF2613; pfam11021"
/db_xref="CDD:151468"
gene 315216..316382
/gene="lpqI"
/locus_tag="BCG_0275"
/db_xref="GeneID:4698823"
CDS 315216..316382
/gene="lpqI"
/locus_tag="BCG_0275"
/note="Differs from Rv0237 by 1aa, L129V"
/codon_start=1
/transl_table=11
/product="lipoprotein lpqI"
/protein_id="YP_976373.1"
/db_xref="GI:121636150"
/db_xref="GeneID:4698823"
/translation="MAFPRTLAILAAAAALVVACSHGGTPTGSSTTSGASPATPVAVP
VPRSCAEPAGIPALLSPRDKLAQLLVVGVRDAADAQAVVTNYHVGGILIGSDTDLTIF
DGALAEIVAGGGPLPLAVSVDEEGGRLSRLRSLIGGTGPSARELAQTRTVQQVRDLAR
DRGRQMRKLGITIDFAPVVDVTDAPDDTVIGDRSFGSDPATVTAYAGAYAQGLRDAGV
LPVLKHFPGHGRGSGDSHNGGVTTPPLDDLVGDDLVPYRTLVTQAPVGVMVGHLQVPG
LTGSEPASLSKAAVNLLRTGTGYGAPPFDGPVFSDDLSGMAAISDRFGVSEAVLRTLQ
AGADIALWVTTKEVPAVLDRLEQALRAGELPMSAVDRSVVRVATMKGPNPGCGR"
misc_feature 315390..>316355
/gene="lpqI"
/locus_tag="BCG_0275"
/note="Beta-glucosidase-related glycosidases [Carbohydrate
transport and metabolism]; Region: BglX; COG1472"
/db_xref="CDD:31661"
misc_feature 315393..316352
/gene="lpqI"
/locus_tag="BCG_0275"
/note="Glycosyl hydrolase family 3 N terminal domain;
Region: Glyco_hydro_3; cl07971"
/db_xref="CDD:208801"
gene 316458..317072
/locus_tag="BCG_0276"
/db_xref="GeneID:4698156"
CDS 316458..317072
/locus_tag="BCG_0276"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976374.1"
/db_xref="GI:121636151"
/db_xref="GeneID:4698156"
/translation="MAGGTKRLPRAVREQQMLDAAVQMFSVNGYHETSMDAIAAEAQI
SKPMLYLYYGSKEDLFGACLNREMSRFIDALRSSINFDQSPKDLLRNTIVSFLRYIDA
NRASWIVMYTQATSSQAFAHTVREGREQIVQLVAELVRAGTRGPLTDAEIEMMAVALV
GAGEAVATRLGIGDTDVDEAAEMMINLFWLGLKGAPVDRLETGH"
misc_feature 316458..317042
/locus_tag="BCG_0276"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature 316509..316646
/locus_tag="BCG_0276"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 317134..317367
/locus_tag="BCG_0277"
/db_xref="GeneID:4696734"
CDS 317134..317367
/locus_tag="BCG_0277"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976375.1"
/db_xref="GI:121636152"
/db_xref="GeneID:4696734"
/translation="MIRTQVQLPDELYRDAKRVAHEHEMTLAEVVRRGLEHMVRIYPR
RDAASDTWQPPTPRRLGPFRASEETWRELANEA"
gene 317375..317812
/locus_tag="BCG_0278"
/db_xref="GeneID:4698779"
CDS 317375..317812
/locus_tag="BCG_0278"
/note="Differs from Rv0240 by 1aa, S31A"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976376.1"
/db_xref="GI:121636153"
/db_xref="GeneID:4698779"
/translation="MLSIDTNILLYAQNRDCPEHDAAAAFLVECSGRADVAVCELVLM
ELYQLLRNPTVVTRPLEGPEAAEVCQTFRRNRRWALLENAPVMNEVWVLAATPRIARR
RLFDARLALTLRHHGVDEFATRNINGFTDFGFSRVWDPITSDG"
misc_feature 317375..317803
/locus_tag="BCG_0278"
/note="Mycobacterium tuberculosis PIN domain family;
Region: Mtu_PIN_fam; TIGR00028"
/db_xref="CDD:129139"
gene complement(317842..318684)
/locus_tag="BCG_0279c"
/db_xref="GeneID:4698015"
CDS complement(317842..318684)
/locus_tag="BCG_0279c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976377.1"
/db_xref="GI:121636154"
/db_xref="GeneID:4698015"
/translation="MTQPSGLKNLLRAAAGALPVVPRTDQLPNRTVTVEELPIDPANV
AAYAAVTGLRYGNQVPLTYPFALTFPSVMSLVTGFDFPFAAMGAIHTENHITQYRPIA
VTDAVGVRVRAENLREHRRGLLVDLVTNVSVGNDVAWHQVTTFLHQQRTSLSGEPKPP
PQKKPKLPPPAAVLRITPAKIRRYAAVGGDHNPIHTNPIAAKLFGFPTVIAHGMFTAA
AVLANIEARFPDAVRYSVRFAKPVLLPATAGLYVAEGDGGWDLTLRNMAKGYPHLTAT
VRGL"
misc_feature complement(318298..>318567)
/locus_tag="BCG_0279c"
/note="The hotdog fold was initially identified in the E.
coli FabA (beta-hydroxydecanoyl-acyl carrier protein
(ACP)-dehydratase) structure and subsequently in 4HBT
(4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A
number of other seemingly unrelated...; Region: hot_dog;
cl00509"
/db_xref="CDD:241913"
misc_feature complement(317857..318165)
/locus_tag="BCG_0279c"
/note="MaoC like domain; Region: MaoC_dehydratas;
pfam01575"
/db_xref="CDD:216580"
misc_feature complement(order(317962..317973,318046..318051))
/locus_tag="BCG_0279c"
/note="active site 2 [active]"
/db_xref="CDD:239524"
misc_feature complement(order(317986..317994,318016..318018,
318031..318033))
/locus_tag="BCG_0279c"
/note="active site 1 [active]"
/db_xref="CDD:239524"
gene complement(318695..320059)
/gene="fabG"
/locus_tag="BCG_0280c"
/db_xref="GeneID:4695780"
CDS complement(318695..320059)
/gene="fabG"
/locus_tag="BCG_0280c"
/EC_number="1.1.1.100"
/note="Catalyzes the first of the two reduction steps in
the elongation cycle of fatty acid synthesis"
/codon_start=1
/transl_table=11
/product="3-ketoacyl-ACP reductase"
/protein_id="YP_976378.1"
/db_xref="GI:121636155"
/db_xref="GeneID:4695780"
/translation="MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPL
TGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGL
HEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTAL
VYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIV
TGAARGIGATIAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDK
ISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNG
SIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGF
IETQMTAAIPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQA
MIGA"
misc_feature complement(318698..320041)
/gene="fabG"
/locus_tag="BCG_0280c"
/note="3-ketoacyl-(acyl-carrier-protein) reductase;
Provisional; Region: fabG; PRK08261"
/db_xref="CDD:236207"
misc_feature complement(318716..319363)
/gene="fabG"
/locus_tag="BCG_0280c"
/note="Rossmann-fold NAD(P)(+)-binding proteins; Region:
NADB_Rossmann; cl09931"
/db_xref="CDD:245206"
misc_feature complement(order(318881..318892,318968..318970,
318980..318982,319019..319027,319169..319177,
319322..319330))
/gene="fabG"
/locus_tag="BCG_0280c"
/note="NAD(P) binding site [chemical binding]; other site"
/db_xref="CDD:187535"
misc_feature complement(order(318968..318970,318980..318982,
319019..319021,319103..319105))
/gene="fabG"
/locus_tag="BCG_0280c"
/note="active site"
/db_xref="CDD:187535"
gene 320201..321523
/gene="fadA2"
/locus_tag="BCG_0281"
/db_xref="GeneID:4697071"
CDS 320201..321523
/gene="fadA2"
/locus_tag="BCG_0281"
/EC_number="2.3.1.9"
/note="Catalyzes the synthesis of acetoacetyl coenzyme A
from two molecules of acetyl coenzyme A. It can also act
as a thiolase, catalyzing the reverse reaction and
generating two-carbon units from the four-carbon product
of fatty acid oxidation"
/codon_start=1
/transl_table=11
/product="acetyl-CoA acetyltransferase"
/protein_id="YP_976379.1"
/db_xref="GI:121636156"
/db_xref="GeneID:4697071"
/translation="MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAA
LSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTG
LQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLV
GTLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDR
GFFDDLVSPFLGLYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASV
ALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQD
FDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPF
AATGGRILAQTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA"
misc_feature 320219..321520
/gene="fadA2"
/locus_tag="BCG_0281"
/note="acetyl-CoA acetyltransferase; Provisional; Region:
PRK09268"
/db_xref="CDD:236440"
misc_feature 320246..321520
/gene="fadA2"
/locus_tag="BCG_0281"
/note="Thiolase are ubiquitous enzymes that catalyze the
reversible thiolytic cleavage of 3-ketoacyl-CoA into
acyl-CoA and acetyl-CoA, a 2-step reaction involving a
covalent intermediate formed with a catalytic cysteine.
They are found in prokaryotes and...; Region: thiolase;
cd00751"
/db_xref="CDD:238383"
misc_feature order(320300..320302,320381..320383,320423..320425,
320432..320434,320444..320446,320477..320488,
320510..320512,320531..320536,320543..320545,
320588..320590,321095..321097,321101..321103,
321107..321109,321179..321181,321488..321493)
/gene="fadA2"
/locus_tag="BCG_0281"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:238383"
misc_feature order(320495..320497,321368..321370,321479..321481)
/gene="fadA2"
/locus_tag="BCG_0281"
/note="active site"
/db_xref="CDD:238383"
gene complement(321829..323664)
/gene="fadE5"
/locus_tag="BCG_0282c"
/db_xref="GeneID:4698442"
CDS complement(321829..323664)
/gene="fadE5"
/locus_tag="BCG_0282c"
/EC_number="1.3.99.-"
/note="Differs from Mb0250c by 1aa, N503D and from Rv0244c
by 3aa, R394K, A479E, N503D"
/codon_start=1
/transl_table=11
/product="acyl-CoA dehydrogenase fadE5"
/protein_id="YP_976380.1"
/db_xref="GI:121636157"
/db_xref="GeneID:4698442"
/translation="MSHYRSNVRDQVFNLFEVLGVDKALGHGEFSDVDVDTARDMLAE
VSRLAEGPVAESFVEGDRNPPVFDPKTHSVMLPESFKKSVNAMLEAGWDKVGIDEALG
GMPMPKAVVWALHEHILGANPAVWMYAGGAGFAQILYHLGTEEQKKWAVLAAERGWGS
TMVLTEPDAGSDVGAARTKAVQQADGSWHIDGVKRFITSGDSGDLFENIFHLVLARPE
GAGPGTKGLSLYFVPKFLFDVETGEPGERNGVFVTNVEHKMGLKVSATCELAFGQHGV
PAKGWLVGEVHNGIAQMFEVIEQARMMVGTKAIATLSTGYLNALQYAKSRVQGADLTQ
MTDKTAPRVTITHHPDVRRSLMTQKAYAEGLRALYLYTATFQDAAVAEVVHGVDAKLA
VRVNDLMLPVVKGVGSEQAYAKLTESLQTLGGSGFLQDYPIEQYIRDAKIDSLYEGTT
AIQAQDFFFRKIVRDKGVALAHVSGQIQAFVDSGAGNGRLKTERALLAKALTNVQGMA
AALTGYLMAAQQDVTSLYKVGLGSVRFLMSVGDLIIGWLLQRQAAVAVAALDAGATGD
ERSFYEGKVAVASFFAKNFLPLLTSTREVIETLDNDIMELDEAAF"
misc_feature complement(323563..323661)
/gene="fadE5"
/locus_tag="BCG_0282c"
/note="Acyl-CoA dehydrogenase N terminal; Region:
AcylCoA_DH_N; pfam12418"
/db_xref="CDD:204911"
misc_feature complement(321832..323658)
/gene="fadE5"
/locus_tag="BCG_0282c"
/note="acyl-CoA dehydrogenase; Provisional; Region:
PTZ00456"
/db_xref="CDD:185635"
misc_feature complement(322276..323544)
/gene="fadE5"
/locus_tag="BCG_0282c"
/note="Putative acyl-CoA dehydrogenases similar to fadE5;
Region: ACAD_fadE5; cd01153"
/db_xref="CDD:173842"
misc_feature complement(order(322312..322314,322318..322320,
322339..322341,323071..323073,323077..323079,
323152..323157,323170..323175,323179..323181))
/gene="fadE5"
/locus_tag="BCG_0282c"
/note="FAD binding site [chemical binding]; other site"
/db_xref="CDD:173842"
misc_feature complement(order(322321..322326,322990..322992,
323152..323154))
/gene="fadE5"
/locus_tag="BCG_0282c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173842"
misc_feature complement(322321..322326)
/gene="fadE5"
/locus_tag="BCG_0282c"
/note="catalytic residues [active]"
/db_xref="CDD:173842"
misc_feature complement(321841..322251)
/gene="fadE5"
/locus_tag="BCG_0282c"
/note="Acetyl-CoA dehydrogenase C-terminal like; Region:
Acyl-CoA_dh_C; pfam12806"
/db_xref="CDD:205085"
gene 324036..324524
/locus_tag="BCG_0283"
/db_xref="GeneID:4696256"
CDS 324036..324524
/locus_tag="BCG_0283"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976381.1"
/db_xref="GI:121636158"
/db_xref="GeneID:4696256"
/translation="MNSTNNLTPSSLREAFGHFPTGVVAIAAEVDGVRQGLAASTFVP
VSLEPPLVSFCVQNTSTTWPKLTGVPMLGISVLGEAHDAAVRTLAAKTGDRFAGLETV
SNDAGAVFIKGTSVWLESAIEQLVPAGDHTIVVLRVNQVKVDPNVAPIVFHRSVLRRL
GV"
misc_feature 324081..324500
/locus_tag="BCG_0283"
/note="Flavin reductase like domain; Region:
Flavin_Reduct; smart00903"
/db_xref="CDD:214900"
gene 324840..326150
/locus_tag="BCG_0284"
/db_xref="GeneID:4698092"
CDS 324840..326150
/locus_tag="BCG_0284"
/note="Differs from Rv0246 by 1aa, A129V"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976382.1"
/db_xref="GI:121636159"
/db_xref="GeneID:4698092"
/translation="MAKTSHRVSSADGMSKRILRLIIAQSGFYSAALQLGNVSIVLPF
VVAELDAELWIAALIFPAFTAGGAIGNVVAPPAVAAVPRRHRLFIIVSCLAVLAGVNA
LCATIGKGSVAGILLVVNVTLIGVVSAISFVAFADLVAAMPSGTARARILLTEVGVGA
ALTAVVAATLSFVPDQHPLSRNIHLLWTAAVAMAISAAICRALPHRIVPRVHAAPGLH
KLVYVGWTAIRTNGWYRRYLLVQVLFGSVVLGSSFHSIRVAAVPGDQPDEVVAVVLFV
CVGLLGGIALWNRVRERFGLVGLFVGSALVSIAAAVLSIAFDLAGAWPNVVAIGLVIA
LVSIANQSVFTAGQLWIARDAEPGLRTSLISFGQLVINAGLVGMGLALGLIAQDHDAV
WPVMIVLLLNLTAAYSATRFAPAKSVDVRGLPQVSRTSRPKTGG"
gene complement(326147..326893)
/locus_tag="BCG_0285c"
/db_xref="GeneID:4698720"
CDS complement(326147..326893)
/locus_tag="BCG_0285c"
/EC_number="1.3.99.1"
/note="catalyzes the fumarate and succinate
interconversion; fumarate reductase is used under
anaerobic conditions with glucose or glycerol as carbon
source"
/codon_start=1
/transl_table=11
/product="fumarate reductase iron-sulfur subunit"
/protein_id="YP_976383.1"
/db_xref="GI:121636160"
/db_xref="GeneID:4698720"
/translation="MTYSASMRVWRGDESCGELREFTVEVNEGEVVLDVILRLQQTQT
PDLAVRWNCKAGKCGSCSAEINGKPRLMCMTRMSTFDEDEIVTVTPMRTFPVIRDLVT
DVSFNYQKAREIPSFAPPKELQPSEYRMAQVDVARSQEFRKCIECFLCQNVCHVVRDH
EENKDAFAGPRFLMRIAELEMHPLDTRDRRSQAQEEHGLGYCNITKCCTEVCPENIKI
TDNALIPMKERVADRKYDPVVWLGSKLFRR"
misc_feature complement(326150..326893)
/locus_tag="BCG_0285c"
/note="fumarate reductase iron-sulfur subunit;
Provisional; Region: PRK12386"
/db_xref="CDD:237086"
misc_feature complement(326657..326848)
/locus_tag="BCG_0285c"
/note="2Fe-2S iron-sulfur cluster binding domain.
Iron-sulfur proteins play an important role in electron
transfer processes and in various enzymatic reactions. The
family includes plant and algal ferredoxins, which act as
electron carriers in photosynthesis...; Region: fer2;
cd00207"
/db_xref="CDD:238126"
misc_feature complement(order(326675..326680,326711..326722,
326726..326728,326735..326737,326744..326749))
/locus_tag="BCG_0285c"
/note="catalytic loop [active]"
/db_xref="CDD:238126"
misc_feature complement(order(326675..326677,326711..326713,
326720..326722,326735..326737))
/locus_tag="BCG_0285c"
/note="iron binding site [ion binding]; other site"
/db_xref="CDD:238126"
gene complement(326894..328834)
/gene="sdhA"
/locus_tag="BCG_0286c"
/db_xref="GeneID:4695826"
CDS complement(326894..328834)
/gene="sdhA"
/locus_tag="BCG_0286c"
/EC_number="1.3.5.1"
/note="part of four member succinate dehydrogenase enzyme
complex that forms a trimeric complex (trimer of
tetramers); SdhA/B are the catalytic subcomplex and can
exhibit succinate dehydrogenase activity in the absence of
SdhC/D which are the membrane components and form
cytochrome b556; SdhC binds ubiquinone; oxidizes succinate
to fumarate while reducing ubiquinone to ubiquinol"
/codon_start=1
/transl_table=11
/product="succinate dehydrogenase flavoprotein subunit"
/protein_id="YP_976384.1"
/db_xref="GI:121636161"
/db_xref="GeneID:4695826"
/translation="MVEVERHSYDVVVIGAGGAGLRAVIEARERGLKVAVVCKSLFGK
AHTVMAEGGCAAAMGNANPKDNWKTHFGDTMRGGKFLNNWRMAELHAKEAPDRVWELE
TYGALFDRTDDGRISQRNFGGHTYPRLAHVGDRTGLELIRTLQQKVVSLQQEDHAELG
DYEARIKVFAECTITELLKDQGAIAGAFGYWRESGRFIVFEAPAVVLATGGIGKSFKV
TSNSWEYTGDGHALALRAGATLINMEFVQFHPTGMVWPPSVKGILVTEGVRGDGGVLK
NSENSRFMFDYIPPVFKGQYAETEEEADQWLKDNDSARRTPDLLPRDEVARAINSEVK
AGRGTPHGGVYLDIASRLTPAEIKRRLPSMYHQFKELAEVDITTQAMEVGPTCHYVMG
GVEVDADTGAATVPGLFAAGECAGGMHGSNRLGGNSLSDLLVFGRRAGLGAADYVRAL
SSRPAVSAEAIDAAAQQALSPFEGPKDGSAPENPYALHMDLQYVMNDLVGIIRNADEI
SRALTLLAELWSRYHNVLVEGHRQYNPGWNLSIDLRNMLLVSECVARAALQRTESRGG
HTRDDHPGMDPNWRRILLVCRATETMGTGGSGSGDSNCHINVTQQLQTPMRPDLLELF
EISELEKYYTDEELAEHPGRRG"
misc_feature complement(326915..328834)
/gene="sdhA"
/locus_tag="BCG_0286c"
/note="succinate dehydrogenase flavoprotein subunit;
Reviewed; Region: sdhA; PRK07803"
/db_xref="CDD:236101"
misc_feature complement(327512..328810)
/gene="sdhA"
/locus_tag="BCG_0286c"
/note="L-aspartate oxidase; Provisional; Region: PRK06175"
/db_xref="CDD:180442"
misc_feature complement(<327092..327373)
/gene="sdhA"
/locus_tag="BCG_0286c"
/note="Fumarate reductase flavoprotein C-term; Region:
Succ_DH_flav_C; pfam02910"
/db_xref="CDD:217281"
gene complement(328865..329686)
/locus_tag="BCG_0287c"
/db_xref="GeneID:4696782"
CDS complement(328865..329686)
/locus_tag="BCG_0287c"
/codon_start=1
/transl_table=11
/product="succinate dehydrogenase membrane anchor subunit"
/protein_id="YP_976385.1"
/db_xref="GI:121636162"
/db_xref="GeneID:4696782"
/translation="MSAPTANRPAIGVFTPTRAQIPERTLRTDLWWLPPLLTNLGLLA
FICYATTRAFWGSQYWVEKYHYLTPFYSPCVSASCQPGASHLGVWFGHFPGWIPLGAM
VLPFLLGFRLTCYYYRKAYYRSVWQSPTSCAVPEPRAHYTGETRLPLIVQNTHRYFFY
IAVVVSLINTYDAIAAFHSPSGFGFGLGNVILTINVVLLWAYTISCHSCRHATGGRLK
HFSKHPVRYWIWTQVSKLNTRHMQFAWITLGTLALTDFYIMLVASGSITDLRFIG"
gene complement(329766..330059)
/locus_tag="BCG_0288c"
/db_xref="GeneID:4697759"
CDS complement(329766..330059)
/locus_tag="BCG_0288c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976386.1"
/db_xref="GI:121636163"
/db_xref="GeneID:4697759"
/translation="MSTTAELAELHDLVGGLRRCVTALKARFGDNPATRRIVIDADRI
LTDIELLDTDVSELDLERAAVPQPSEKIAIPDTEYDREFWRDVDDEGVGGHRY"
gene complement(330204..330683)
/gene="hsp"
/locus_tag="BCG_0289c"
/db_xref="GeneID:4695359"
CDS complement(330204..330683)
/gene="hsp"
/locus_tag="BCG_0289c"
/standard_name="hsp 20; hrpA; acr2"
/codon_start=1
/transl_table=11
/product="heat shock protein hsp"
/protein_id="YP_976387.1"
/db_xref="GI:121636164"
/db_xref="GeneID:4695359"
/translation="MNNLALWSRPVWDVEPWDRWLRDFFGPAATTDWYRPVAGDFTPA
AEIVKDGDDAVVRLELPGIDVDKDVNVELDPGQPVSRLVIRGEHRDEHTQDAGDKDGR
TLREIRYGSFRRSFRLPAHVTSEAIAASYDAGVLTVRVAGAYKAPAETQAQRIAITK"
misc_feature complement(330213..330632)
/gene="hsp"
/locus_tag="BCG_0289c"
/note="Molecular chaperone (small heat shock protein)
[Posttranslational modification, protein turnover,
chaperones]; Region: IbpA; COG0071"
/db_xref="CDD:223149"
misc_feature complement(330264..330542)
/gene="hsp"
/locus_tag="BCG_0289c"
/note="Alpha-crystallin domain (ACD) of
alpha-crystallin-type small(s) heat shock proteins (Hsps).
sHsps are small stress induced proteins with monomeric
masses between 12 -43 kDa, whose common feature is the
Alpha-crystallin domain (ACD). sHsps are generally...;
Region: ACD_sHsps-like; cd06464"
/db_xref="CDD:107221"
misc_feature complement(order(330279..330284,330342..330344,
330498..330503,330507..330509,330513..330515,
330531..330542))
/gene="hsp"
/locus_tag="BCG_0289c"
/note="putative dimer interface [polypeptide binding];
other site"
/db_xref="CDD:107221"
gene 330897..333458
/gene="nirB"
/locus_tag="BCG_0290"
/db_xref="GeneID:4697339"
CDS 330897..333458
/gene="nirB"
/locus_tag="BCG_0290"
/EC_number="1.7.1.4"
/codon_start=1
/transl_table=11
/product="nitrite reductase NAD(P)H] large subunit"
/protein_id="YP_976388.1"
/db_xref="GI:121636165"
/db_xref="GeneID:4697339"
/translation="MPTAGSSRAPAAAREIVVVGHGMVGHRLVEAVRARDADGSLRIT
VLAEEGDAAYDRVGLTSYTESWDRALLALPGNDYAGDQRVRLLLNTRVTQIDRATKSV
VTAAGQRHRYDTLVLATGSYAFVPPVPGHDLPACHVYRTFDDLDAIRAGAQRTLDGGH
TDGGVVIGGGLLGLEAANALRQFGLQTHVVEMMPRLMAQQIDEAGGALLARMIADLGI
AVHVGTGTESIESVKHSDGSVWARVRLSDGEVIDAGVVIFAAGIRPRDELARAAGLAI
GDRGGVLTDLSCRTSDPDIYAVGEVAAIDGRCYGLVGPGYTSAEVVADRLLDGSAEFP
EADLSTKLKLLGVDVASFGDAMGATENCLEVVINDAVKRTYAKLVLSDDATTLLGGVL
VGDASSYGVLRPMVGAELPGDPLALIAPAGSGAGAGALGVGALPDSAQICSCNNVTKG
ELKCAIADGCGDVPALKSCTAAGTSCGSCVPLLKQLLEAEGVEQSKALCEHFSQSRAE
LFEIITATEVRTFSGLLDRFGRGKGCDICKPVVASILASTGSDHILDGEQASLQDSND
HFLANIQKNGSYSVVPRVPGGDIKPEHLILIGQIAQDFGLYTKITGGQRIDLFGARVD
QLPLIWQRLVDGGMESGHAYGKAVRTVKSCVGSDWCRYGQQDSVQLAIDLELRYRGLR
APHKIKLGVSGCARECAEARGKDVGVIATEKGWNLYVAGNGGMTPKHAQLLASDLDKE
TLIRYIDRFLIYYIRTADRLQRTAPWVESLGLDHVREVVCEDSLGLAEEFEAAMQRHV
ANYKCEWKGVLEDPDKLSRFVSFVNAPDAVDSTVTFTERAGRKVPVSIGIPRVRS"
misc_feature 330942..333332
/gene="nirB"
/locus_tag="BCG_0290"
/note="nitrite reductase [NAD(P)H], large subunit; Region:
nitri_red_nirB; TIGR02374"
/db_xref="CDD:162827"
misc_feature 331419..331643
/gene="nirB"
/locus_tag="BCG_0290"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox; pfam00070"
/db_xref="CDD:215691"
misc_feature 332211..332366
/gene="nirB"
/locus_tag="BCG_0290"
/note="BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD;
pfam04324"
/db_xref="CDD:218027"
misc_feature 332613..332795
/gene="nirB"
/locus_tag="BCG_0290"
/note="Nitrite/Sulfite reductase ferredoxin-like half
domain; Region: NIR_SIR_ferr; pfam03460"
/db_xref="CDD:217572"
gene 333484..333840
/gene="nirD"
/locus_tag="BCG_0291"
/db_xref="GeneID:4699206"
CDS 333484..333840
/gene="nirD"
/locus_tag="BCG_0291"
/EC_number="1.7.1.4"
/codon_start=1
/transl_table=11
/product="nitrite reductase [NAD(P)H] small subunit nirD"
/protein_id="YP_976389.1"
/db_xref="GI:121636166"
/db_xref="GeneID:4699206"
/translation="MTLLNDIQVWTTACAYDHLIPGRGVGVLLDDGSQVALFRLDDGS
VHAVGNVDPFSGAAVMSRGIVGDRGGRAMVQSPILKQAFALDDGSCLDDPRVSVPVYP
ARVTPEGRIQVARVAV"
misc_feature 333511..333825
/gene="nirD"
/locus_tag="BCG_0291"
/note="Assimilatory nitrite reductase (NirD) family,
Rieske domain; Assimilatory nitrate and nitrite reductases
convert nitrate through nitrite to ammonium. Members
include bacterial and fungal proteins. The bacterial NirD
contains a single Rieske domain while...; Region:
Rieske_NirD; cd03529"
/db_xref="CDD:239605"
gene complement(333856..334380)
/gene="cobU"
/locus_tag="BCG_0292c"
/db_xref="GeneID:4699207"
CDS complement(333856..334380)
/gene="cobU"
/locus_tag="BCG_0292c"
/EC_number="2.-.-.-"
/codon_start=1
/transl_table=11
/product="bifunctional cobalamin biosynthesis protein
cobU: cobinamide kinase + cobinamide phosphate
guanylyltransferase"
/protein_id="YP_976390.1"
/db_xref="GI:121636167"
/db_xref="GeneID:4699207"
/translation="MRILVTGGVRSGKSTHAEALLGDAADVVYVAPGRPAAGSDPDWD
ARVALHRARRPPTWLTVETADVATALSEARSPVLVDCLGTWLTAIMDGEALWSAATAD
VYAVLEARLDGLCAALTGLPTAIVVTNEVGLGVVPSHSSGVLFRDLLGTINRRVAAVC
DEVHLVIAGRVLKL"
misc_feature complement(333859..334377)
/gene="cobU"
/locus_tag="BCG_0292c"
/note="Adenosylcobinamide kinase / adenosylcobinamide
phosphate guanyltransferase (CobU). CobU is bifunctional
cobalbumin biosynthesis enzymes which display
adenosylcobinamide kinase and adenosylcobinamide phosphate
guanyltransferase activity. This enzyme is a...; Region:
CobU; cd00544"
/db_xref="CDD:238304"
misc_feature complement(order(333871..333873,333877..333879,
333910..333912,333919..333924,333928..333933,
333943..333945,333976..333978,333982..333993,
334345..334347,334351..334359))
/gene="cobU"
/locus_tag="BCG_0292c"
/note="homotrimer interface [polypeptide binding]; other
site"
/db_xref="CDD:238304"
misc_feature complement(334339..334359)
/gene="cobU"
/locus_tag="BCG_0292c"
/note="Walker A motif; other site"
/db_xref="CDD:238304"
misc_feature complement(order(334138..334143,334195..334197,
334219..334221,334228..334230,334282..334284,
334339..334353))
/gene="cobU"
/locus_tag="BCG_0292c"
/note="GTP binding site [chemical binding]; other site"
/db_xref="CDD:238304"
misc_feature complement(334141..334155)
/gene="cobU"
/locus_tag="BCG_0292c"
/note="Walker B motif; other site"
/db_xref="CDD:238304"
gene complement(334405..335889)
/gene="cobQ1"
/locus_tag="BCG_0293c"
/db_xref="GeneID:4697940"
CDS complement(334405..335889)
/gene="cobQ1"
/locus_tag="BCG_0293c"
/note="catalyzes amidations at positions B, D, E, and G on
adenosylcobyrinic A,C-diamide. NH(2) groups are provided
by glutamine, and one molecule of ATP is hydrogenolyzed
for each amidation"
/codon_start=1
/transl_table=11
/product="cobyric acid synthase"
/protein_id="YP_976391.1"
/db_xref="GI:121636168"
/db_xref="GeneID:4697940"
/translation="MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNN
SMVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWGEV
ASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGDYVNMGLARHAG
LPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNKFRGDSDLLAPGLRDLERV
TGRRVYGTLPWHPDLWLDSEDALDLQGRRAAGTGARRVAVVRLPRISNFTDVDALGLE
PDLDVVFASDPRALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGIC
GGFQMLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGVPASG
YEIHHGRITRGDTAEEFLGGARDGPVFGTMWHGSLEGDALREAFLRETLGLAPSGSCF
LAARERRLDLLGDLVERHLDVDALLNLARHGCPPTLPFLAPGAP"
misc_feature complement(334456..335889)
/gene="cobQ1"
/locus_tag="BCG_0293c"
/note="cobyric acid synthase; Provisional; Region:
PRK00784"
/db_xref="CDD:234838"
misc_feature complement(335194..335889)
/gene="cobQ1"
/locus_tag="BCG_0293c"
/note="Dethiobiotin synthetase [Coenzyme metabolism];
Region: BioD; COG0132"
/db_xref="CDD:223210"
misc_feature complement(334579..335109)
/gene="cobQ1"
/locus_tag="BCG_0293c"
/note="Type 1 glutamine amidotransferase (GATase1) domain
found in Cobyric Acid Synthase (CobQ); Region:
GATase1_CobQ; cd01750"
/db_xref="CDD:153221"
misc_feature complement(order(334696..334698,334702..334704,
334888..334890))
/gene="cobQ1"
/locus_tag="BCG_0293c"
/note="catalytic triad [active]"
/db_xref="CDD:153221"
gene complement(335908..337578)
/gene="PPE2"
/locus_tag="BCG_0294c"
/db_xref="GeneID:4698555"
CDS complement(335908..337578)
/gene="PPE2"
/locus_tag="BCG_0294c"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976392.1"
/db_xref="GI:121636169"
/db_xref="GeneID:4698555"
/translation="MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIAYAET
ADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMATRQETAATAYGT
ALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNESDYARMWIQAATTMASYQAV
STAAVAAAPQTTPAPQIVKANAPTAASDEPNQVQEWLQWLQKIGYTDFYNNVIQPFIN
WLTNLPFLQAMFSGFDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFI
GADLAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPLLA
APLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIPTPTPTPAPAP
APTAVTAPTPPPGPPPPPVTAPPPVTGAGIQSFGYLVGDLNSAAQARKAVGTGVRKKT
PEPDSAEAPAAAAAPEEQVQPQRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQGAGT
LGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE"
misc_feature complement(<336763..337569)
/gene="PPE2"
/locus_tag="BCG_0294c"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:227938"
misc_feature complement(337117..337557)
/gene="PPE2"
/locus_tag="BCG_0294c"
/note="PPE family; Region: PPE; pfam00823"
/db_xref="CDD:216138"
gene 337886..338104
/locus_tag="BCG_0295"
/db_xref="GeneID:4697069"
CDS 337886..338104
/locus_tag="BCG_0295"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a single base transition (c-t) leads
to a truncated product in the 5' direction compared to
Mycobacterium tuberculosis strain H37Rv (72 aa versus 124
aa)"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976393.1"
/db_xref="GI:121636170"
/db_xref="GeneID:4697069"
/translation="MQSVDLHVERHLPSRGRSHRTVATVTCVTALGDIRSAQLSATGA
WPAVLFPSWSWLCGIGGGVDLQKPSCRA"
gene complement(338325..338780)
/locus_tag="BCG_0296c"
/db_xref="GeneID:4695376"
CDS complement(338325..338780)
/locus_tag="BCG_0296c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976394.1"
/db_xref="GI:121636171"
/db_xref="GeneID:4695376"
/translation="MARSQEPSRGLLDPVAKMLRLPFGTPDFIEKIVTGSVNQVGRRT
LYVLITTWDAAGGGPFAASAIATTGLAKTAEIVQSMFIGPVFNPLLKMLGADKIAIRA
SLCAAQLVGLGIMRYGVRSEPLHSMSVEMLVDAIGPTMQRYLVGDIGRG"
gene complement(338805..339548)
/locus_tag="BCG_0297c"
/db_xref="GeneID:4698229"
CDS complement(338805..339548)
/locus_tag="BCG_0297c"
/note="Differs from Rv0259c by 1aa, V182A"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976395.1"
/db_xref="GI:121636172"
/db_xref="GeneID:4698229"
/translation="MNLILTAHGTRRPSGVAMIADIAAQVSALVDRTVQVAFVDVLGP
SPSEVLSALSCRPAIVVPAFLSRGYHVRTDLPAHVAASAHPHVTVTPALGPCREIAQI
VTQQLVESGWRPGDSVILAAAGASDRRARADLHTTRTLVSELTGSWVDMGFAGTGGPD
VRTAVQRARDRAEANRGARRVVVASFLLAEGLFQERLRASGADVVTRPLGTHPGLAQL
VANRFRSAVARQQRLHRWHGTPTPVTLDL"
misc_feature complement(338853..339548)
/locus_tag="BCG_0297c"
/note="Sirohydrochlorin ferrochelatase [Inorganic ion
transport and metabolism]; Region: COG2138"
/db_xref="CDD:225049"
misc_feature complement(<339324..339542)
/locus_tag="BCG_0297c"
/note="Sirohydrochlorin cobalt chelatase (CbiX) and
sirohydrochlorin iron chelatase (SirB), N-terminal domain.
SirB catalyzes the ferro-chelation of sirohydrochlorin to
siroheme, the prosthetic group of sulfite and nitrite
reductases. CbiX is a cobaltochelatase; Region:
CbiX_SirB_N; cd03416"
/db_xref="CDD:239509"
misc_feature complement(order(339339..339341,339525..339527))
/locus_tag="BCG_0297c"
/note="putative active site [active]"
/db_xref="CDD:239509"
misc_feature complement(338868..339203)
/locus_tag="BCG_0297c"
/note="Sirohydrochlorin cobalt chelatase (CbiX) and
sirohydrochlorin iron chelatase (SirB), C-terminal domain.
SirB catalyzes the ferro-chelation of sirohydrochlorin to
siroheme, the prosthetic group of sulfite and nitrite
reductases. CbiX is a cobaltochelatase; Region:
CbiX_SirB_C; cd03414"
/db_xref="CDD:239507"
misc_feature complement(order(338973..338975,339180..339182))
/locus_tag="BCG_0297c"
/note="putative active site [active]"
/db_xref="CDD:239507"
gene complement(339545..340690)
/locus_tag="BCG_0298c"
/db_xref="GeneID:4699345"
CDS complement(339545..340690)
/locus_tag="BCG_0298c"
/EC_number="4.2.1.75"
/note="catalyzes the formation of uroporphyrinogen-III
from hydroxymethylbilane"
/codon_start=1
/transl_table=11
/product="bifunctional uroporphyrinogen-III
synthetase/response regulator domain-containing protein"
/protein_id="YP_976396.1"
/db_xref="GI:121636173"
/db_xref="GeneID:4699345"
/translation="MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKM
IALPDDDELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARII
SRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFP
EFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLE
RSRELDIEDQLLAALRTDVHAMCVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEEL
PLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRV
LPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKRGYRLAVDSRHDDV"
misc_feature complement(339548..340690)
/locus_tag="BCG_0298c"
/note="bifunctional uroporphyrinogen-III
synthetase/response regulator domain protein; Validated;
Region: PRK07239"
/db_xref="CDD:235981"
misc_feature complement(339875..340597)
/locus_tag="BCG_0298c"
/note="Uroporphyrinogen-III synthase (HemD) catalyzes the
asymmetrical cyclization of tetrapyrrole (linear) to
uroporphyrinogen-III, the fourth step in the biosynthesis
of heme. This ubiquitous enzyme is present in eukaryotes,
bacteria and archaea. Mutations in...; Region: HemD;
cd06578"
/db_xref="CDD:119440"
misc_feature complement(order(340055..340069,340148..340150,
340154..340156,340241..340243,340370..340372,
340469..340477))
/locus_tag="BCG_0298c"
/note="active site"
/db_xref="CDD:119440"
misc_feature complement(<339548..339865)
/locus_tag="BCG_0298c"
/note="DNA-binding winged-HTH domains [Transcription];
Region: CadC; COG3710"
/db_xref="CDD:226233"
misc_feature complement(order(339584..339586,339599..339601,
339623..339628,339650..339652,339659..339661,
339707..339712,339767..339769))
/locus_tag="BCG_0298c"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:238225"
gene complement(340790..342199)
/gene="narK3"
/locus_tag="BCG_0299c"
/db_xref="GeneID:4698915"
CDS complement(340790..342199)
/gene="narK3"
/locus_tag="BCG_0299c"
/codon_start=1
/transl_table=11
/product="integral membrane nitrite extrusion protein
narK3"
/protein_id="YP_976397.1"
/db_xref="GI:121636174"
/db_xref="GeneID:4698915"
/translation="MGRSHQISDWDPEDSVAWEAGNKFIARRNLIWSVAAEHVGFSVW
SLWSVMVLFMPTSVYGFSAGDKFLLGATATLVGACLRFPYTFATAKFGGRNWTIFSAL
VLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAASMTNINAFFPQRLKGAALA
LNAGGGNLGVPMVQLVGLLVIATAGDREPYWVCAIYLVLLAVAGLGAALYMDNLTEYR
IELNTMRAVVSEPHTWVISLLYIGTFGSFIGFSFAFGQVLQINFIASGQSTAQASLHA
AQIAFLGPLLGSLSRIYGGKLADRIGGGRVTLAAFCAMLLATGILISASTFGDHLAGP
MPTATMVGYVIGFTALFILSGIGNGSVYKMIPSIFEARSHSLQISEAERRQWSRSMSG
ALIGLAGAVGALGGVGVNLALRESYLTSGTATSAFWAFGVFYLVASVLTWAIYVRRGL
KSAGELVPATTAPAGLAYV"
misc_feature complement(340820..342157)
/gene="narK3"
/locus_tag="BCG_0299c"
/note="Nitrate/nitrite transporter [Inorganic ion
transport and metabolism]; Region: NarK; COG2223"
/db_xref="CDD:225133"
gene complement(342340..342885)
/gene="aac"
/locus_tag="BCG_0300c"
/db_xref="GeneID:4697467"
CDS complement(342340..342885)
/gene="aac"
/locus_tag="BCG_0300c"
/EC_number="2.3.1.-"
/standard_name="aac(2')-IC"
/codon_start=1
/transl_table=11
/product="aminoglycoside 2'-n-acetyltransferase aac"
/protein_id="YP_976398.1"
/db_xref="GI:121636175"
/db_xref="GeneID:4697467"
/translation="MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHT
LGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDA
VEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLP
IDISLDTSAELMCDWRAGDVW"
misc_feature complement(342562..>342684)
/gene="aac"
/locus_tag="BCG_0300c"
/note="N-Acyltransferase superfamily: Various enzymes that
characteristically catalyze the transfer of an acyl group
to a substrate; Region: NAT_SF; cd04301"
/db_xref="CDD:173926"
misc_feature complement(order(342595..342600,342628..342636))
/gene="aac"
/locus_tag="BCG_0300c"
/note="Coenzyme A binding pocket [chemical binding]; other
site"
/db_xref="CDD:173926"
gene complement(342895..343797)
/locus_tag="BCG_0301c"
/db_xref="GeneID:4698700"
CDS complement(342895..343797)
/locus_tag="BCG_0301c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976399.1"
/db_xref="GI:121636176"
/db_xref="GeneID:4698700"
/translation="MTTLEILRSGPLALVEDLGRAGLAHLGVGRSGAADRRSHTLANR
LVANPDDWATVEVTFGGFSARVRGGDVDIAVTGADTDPTVNGIMVGTNSIHHVRDGQV
ISLGTPRAGLRTYLAVRGGVCVEPVLGSRSYDVMSAIGPSPLRAGDVLPVGEHTDDYP
ELDQAPVAAIEEHLVELRVVPGPRDDWLVDPDALVHTIWMASNRSDRVGMRLQGRPLQ
HRWPDRQLPGEGVTRGAIQVPPNGLPVILGPDHPITGSYPVVGVITDEDIDKVAQIRP
GQYVRLHWARPRSRLPGQGVTQAW"
misc_feature complement(342898..343791)
/locus_tag="BCG_0301c"
/note="Allophanate hydrolase subunit 2; Region: AHS2;
cl00865"
/db_xref="CDD:242152"
gene complement(343814..344446)
/locus_tag="BCG_0302c"
/db_xref="GeneID:4699153"
CDS complement(343814..344446)
/locus_tag="BCG_0302c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976400.1"
/db_xref="GI:121636177"
/db_xref="GeneID:4699153"
/translation="MDAALACTVLDYGDHALMLQCDSTADAMAWTDALRAAALPGVVD
IVAASRTVLVKLDAPRYQGVTRQRLRRLRVTPEAVAAADHRCDLVIDVVYDGPDLAEV
ARCTGLTTAAVINAHTATGWRAGFSGSAPGFAYLIDGDPSLRVPRRPERRTSMPPGSV
ALADGFSAIYPSQAPSDWQIIGHTDAVLWDVDRPQPALLTPGMWVQFRAA"
misc_feature complement(343817..344434)
/locus_tag="BCG_0302c"
/note="Allophanate hydrolase subunit 1 [Amino acid
transport and metabolism]; Region: DUR1; COG2049"
/db_xref="CDD:224960"
misc_feature complement(343856..344428)
/locus_tag="BCG_0302c"
/note="Allophanate hydrolase subunit 1; Region: AHS1;
smart00796"
/db_xref="CDD:214820"
gene complement(344542..345534)
/locus_tag="BCG_0303c"
/db_xref="GeneID:4697220"
CDS complement(344542..345534)
/locus_tag="BCG_0303c"
/note="Differs from Rv0265c and Mb0271c by 1aa, C313Y"
/codon_start=1
/transl_table=11
/product="periplasmic iron-transport lipoprotein"
/protein_id="YP_976401.1"
/db_xref="GI:121636178"
/db_xref="GeneID:4697220"
/translation="MRQGCSRRGFLQVAEAAAATGLFAGCSSPKPPPGTPGGAAVTIT
HLFGQTVIKEPPKRVVSAGYTEQDDLLAVDVVPIAVTDWFGDQPFAVWPWAAPKLGGA
RPAVLNLDNGIQIDRIAALKPDLIVAINAGVDADTYQQLSAIAPTVAQSGGDAFFEPW
KDQARSIGQAVFAADRMRSLIEAVDQKFAAVAQRHPRWRGKKALLLQGRLWQGNVVAT
LAGWRTDFLNDMGLVIADSIKPFAVDQRGVIPRDHIKAVLDAADVLIWMTESPEDEKA
LLADPEIAASQATAQRRHIFTSKEQAGAIAFSSVLSCPVVAEQLPPQISQILGA"
misc_feature complement(344692..345375)
/locus_tag="BCG_0303c"
/note="Helical backbone metal receptor (TroA-like domain).
These proteins have been shown to function in the ABC
transport of ferric siderophores and metal ions such as
Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site
is formed in the interface between...; Region: TroA-like;
cl00262"
/db_xref="CDD:213416"
misc_feature complement(344656..345360)
/locus_tag="BCG_0303c"
/note="Periplasmic binding protein; Region: Peripla_BP_2;
pfam01497"
/db_xref="CDD:144914"
misc_feature complement(order(345028..345030,345106..345108,
345115..345120))
/locus_tag="BCG_0303c"
/note="intersubunit interface [polypeptide binding]; other
site"
/db_xref="CDD:29734"
gene complement(345556..349185)
/gene="oplA"
/locus_tag="BCG_0304c"
/db_xref="GeneID:4695900"
CDS complement(345556..349185)
/gene="oplA"
/locus_tag="BCG_0304c"
/EC_number="3.5.2.9"
/codon_start=1
/transl_table=11
/product="5-oxoprolinase"
/protein_id="YP_976402.1"
/db_xref="GI:121636179"
/db_xref="GeneID:4695900"
/translation="MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDA
AVAGIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALRIAYQN
RPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGEKMRQAHADGIRAVAV
VCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRR
YINQVADQMRGVRLMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHV
IGFDMGGTSTDVSHYAGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYR
VGPDSAGADPGPACYRGGGPLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRG
FTDLAADIAARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHDVTRYALTTFGG
AGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTAMREQSVEIPLGPAAPQRLA
SVAESLERAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIPVQLAEIETMATAFESS
HRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETVRIYSNGLWRD
APLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAA
TRAGFEAGFEADPVLLEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALFDPDG
NLVANAPHIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGGTHLPDITVITPV
FNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAE
TRRLLTEAPFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDN
AEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQLDTNFNAP
TSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQA
ITGALFAALGVQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMTNS
RLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMTVSTLSGHRRV
RPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTS
ARRRR"
misc_feature complement(345580..349167)
/gene="oplA"
/locus_tag="BCG_0304c"
/note="5-oxoprolinase; Region: PLN02666"
/db_xref="CDD:215358"
misc_feature complement(348637..349167)
/gene="oplA"
/locus_tag="BCG_0304c"
/note="Hydantoinase/oxoprolinase N-terminal region;
Region: Hydant_A_N; pfam05378"
/db_xref="CDD:218571"
misc_feature complement(347719..348582)
/gene="oplA"
/locus_tag="BCG_0304c"
/note="Hydantoinase/oxoprolinase; Region: Hydantoinase_A;
pfam01968"
/db_xref="CDD:216816"
misc_feature complement(345559..347112)
/gene="oplA"
/locus_tag="BCG_0304c"
/note="N-methylhydantoinase B/acetone carboxylase, alpha
subunit [Amino acid transport and metabolism / Secondary
metabolites biosynthesis, transport, and catabolism];
Region: HyuB; COG0146"
/db_xref="CDD:223224"
gene 349362..350753
/gene="narU"
/locus_tag="BCG_0305"
/db_xref="GeneID:4698680"
CDS 349362..350753
/gene="narU"
/locus_tag="BCG_0305"
/codon_start=1
/transl_table=11
/product="integral membrane nitrite extrusion protein
narU"
/protein_id="YP_976403.1"
/db_xref="GI:121636180"
/db_xref="GeneID:4698680"
/translation="MALTTAPAIDYALPRQQDEGDHWIDDWRPEDPVFWETIGRPIAR
RNLIFSIFAEHVGFSVWMLWSIVVVQMTAAAPGHPAASGWALSASQALCLVAVPSGVG
AFLRLPYTFAIPIFGGRNWTTVSAALLVIPCLLLAWAVSHPSLPFAVLVVIAATAGFG
GGNFASSMANISFFYPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGSGVALSRAG
LFFVPLAVAAAVCAFLFMNNLTEAKADVKPVWQSLRHADTWIMSLLYIGTFGSFIGYS
AAFPTLLKTVFGRGDIALGWAFLGAGIGSLVRPLGGKLADRIGGARITAASFVMLAAG
AAAALWSVQSVNLPVFFVSFMFLFVATGIGNGSSYRMISRIFQVKGEVAGGDPETMVN
MRRQAAGALGIISSIGAFGGFVVPLAYAWSKVHFGNIEPALHFYVAFFLALLVVTWYC
YLRRTTPMGQVGV"
misc_feature 349455..350732
/gene="narU"
/locus_tag="BCG_0305"
/note="Nitrate/nitrite transporter [Inorganic ion
transport and metabolism]; Region: NarK; COG2223"
/db_xref="CDD:225133"
gene complement(350795..351304)
/locus_tag="BCG_0306c"
/db_xref="GeneID:4697469"
CDS complement(350795..351304)
/locus_tag="BCG_0306c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976404.1"
/db_xref="GI:121636181"
/db_xref="GeneID:4697469"
/translation="MGTRSKSRTRQLKQSNGCTATTSGASDRRRRARRRTAPAWLRED
EWLRHHLPHPPRQLSRCLHRRRRSACHHRYSRRTPKGGLPMTSSLVPISEARAHLSRL
VRESADDDVVLMNHGRPAAILISAERYESLMEELEDLRDRLSVHEREHVTMPLDKLGA
ELGVDIGRV"
misc_feature complement(350798..351058)
/locus_tag="BCG_0306c"
/note="Antitoxin of toxin-antitoxin stability system [Cell
division and chromosome partitioning]; Region: StbD;
COG2161"
/db_xref="CDD:225072"
gene complement(351369..352562)
/locus_tag="BCG_0307c"
/db_xref="GeneID:4698669"
CDS complement(351369..352562)
/locus_tag="BCG_0307c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976405.1"
/db_xref="GI:121636182"
/db_xref="GeneID:4698669"
/translation="MSRMAAPVSLDVHGRQVIVTHPGRVVFPAHNDRKGYTKFDLVRY
YLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPANRPDWVDVAELHYASGRSAA
EAVIHDAAGLAWVINLGCVDLNPHPVLAGDLDHPDELRVDLDPMPGVAWQRVVEVALV
VREVLEDYGLTAWPKTSGSRGFHVYARIAPCWSFPQVRLAAQTVAREVERRLPDAATS
RWWKEEREGVFVDFNQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMAT
VPSRLADIGDPWAGMDDAVGRLDRLLMLAEELGPPQKAQSAKPLIEIARAKTRAEAMA
ALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRIRINLQHVPADQRPPQEELIADY
SPWPR"
misc_feature complement(351771..352451)
/locus_tag="BCG_0307c"
/note="LigD_Pol_like_2: Polymerase (Pol) domain of
bacterial LigD proteins similar to Pseudomonas aeruginosa
(Pae) LigD, subgroup 2. The LigD Pol domain belongs to the
archaeal/eukaryal primase (AEP) superfamily. In
prokaryotes, LigD along with Ku is required...; Region:
LigD_Pol_like_2; cd04865"
/db_xref="CDD:240135"
misc_feature complement(order(351813..351821,351843..351845,
351861..351863,351870..351872,352014..352016,
352020..352028,352032..352034,352131..352133,
352137..352139,352191..352193,352329..352331,
352335..352337))
/locus_tag="BCG_0307c"
/note="nucleotide binding site [chemical binding]; other
site"
/db_xref="CDD:240135"
gene 352598..354280
/gene="fadD2"
/locus_tag="BCG_0308"
/db_xref="GeneID:4698035"
CDS 352598..354280
/gene="fadD2"
/locus_tag="BCG_0308"
/EC_number="2.3.1.86"
/note="activates fatty acids by binding to coenzyme A"
/codon_start=1
/transl_table=11
/product="acyl-CoA synthetase"
/protein_id="YP_976406.1"
/db_xref="GI:121636183"
/db_xref="GeneID:4698035"
/translation="MPNLTDLPGQAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGL
EPPLNYAALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAAHAVANG
LLAKGVRAGEGVAILARNHRWFVIANYGAARVGARIILLNSEFSGPQIKEVSDREGAK
VIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSGSSDETLAELIAHSSTAPAPKAS
RRASIIILTSGTTGTPKGANRNTPPTLAPIGGILSHVPFKAGEVTLLPSPMFHALGYM
HAALAMFLGSTLVLRRRFKPALVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDL
SSLKIVFVSGSQLGAELATRALGDLGPVIYNMYGSTEVAFATIAGPKDLQFNPSTVGP
VVKGVTVKILDENGNEVPQGAVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSGDVGYFD
ERGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEAAAIGVDDKEFGARLRAFV
VKKPGADLDEDTIKQYVRDHLARYKVPREVIFLDELPRNPTGKVLKRELRKL"
misc_feature 352637..354277
/gene="fadD2"
/locus_tag="BCG_0308"
/note="acyl-CoA synthetase; Validated; Region: PRK07788"
/db_xref="CDD:181117"
misc_feature 352847..>353092
/gene="fadD2"
/locus_tag="BCG_0308"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:213459"
misc_feature 353297..354271
/gene="fadD2"
/locus_tag="BCG_0308"
/note="Adenylate forming domain, Class I; Region:
AFD_class_I; cl17068"
/db_xref="CDD:213459"
misc_feature order(353396..353401,353537..353539,353543..353548,
353555..353557,353624..353629,353690..353707,
353930..353932,353966..353968,353975..353977,
353999..354010,354191..354193)
/gene="fadD2"
/locus_tag="BCG_0308"
/note="active site"
/db_xref="CDD:213270"
misc_feature order(353396..353398,353543..353548,353555..353557,
353624..353626,353999..354007,354173..354175,
354191..354193)
/gene="fadD2"
/locus_tag="BCG_0308"
/note="CoA binding site [chemical binding]; other site"
/db_xref="CDD:213270"
misc_feature order(353624..353629,353690..353707,353930..353932,
353966..353968,353975..353977,354008..354010,
354248..354250)
/gene="fadD2"
/locus_tag="BCG_0308"
/note="AMP binding site [chemical binding]; other site"
/db_xref="CDD:213270"
gene complement(354297..356492)
/gene="fadE6"
/locus_tag="BCG_0309c"
/db_xref="GeneID:4695420"
CDS complement(354297..356492)
/gene="fadE6"
/locus_tag="BCG_0309c"
/EC_number="1.3.99.-"
/codon_start=1
/transl_table=11
/product="acyl-CoA dehydrogenase fadE6"
/protein_id="YP_976407.1"
/db_xref="GI:121636184"
/db_xref="GeneID:4695420"
/translation="MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENPPPYW
QAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSAIASALIAAHDP
QAKVLAELATGAAIAAYALDSGLTATRHGDVLVIRGEVRAVPAAAQASVLVLPVAIES
RDEWVVLRNDQLEIEAVKSLDPLRPIAHVRANAVDVSDDALLSNLTMTTAHALMSTLL
SAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMIADTERATAAVWDAAR
ALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCIQVHGGIGFTWEHDTNVYYRRALM
LAACFGRGSEYPQRVVDTATTAGMRPVDIDLDPSTEKLRAQIRAEVAALKAMPREPRT
VAIAEGGWVLPYLPKPWGRAASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGT
DNQKQRLLPPTFRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQ
YSQWGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLDDVFVP
DELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVRDYRFEGQFDQVAR
HRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAISKLLSMRTGQGYAEFAVSSFGT
DAVIGDTERLPGKWGEYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP"
misc_feature complement(355473..356492)
/gene="fadE6"
/locus_tag="BCG_0309c"
/note="Acyl-CoA dehydrogenases [Lipid metabolism]; Region:
CaiA; COG1960"
/db_xref="CDD:224871"
misc_feature complement(355488..356474)
/gene="fadE6"
/locus_tag="BCG_0309c"
/note="Acyl-CoA dehydrogenase; Region: ACAD; cl09933"
/db_xref="CDD:245208"
misc_feature complement(354315..355394)
/gene="fadE6"
/locus_tag="BCG_0309c"
/note="Putative acyl-CoA dehydrogenases similar to fadE6,
fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152"
/db_xref="CDD:173841"
misc_feature complement(354300..355385)
/gene="fadE6"
/locus_tag="BCG_0309c"
/note="Acyl-CoA dehydrogenases [Lipid metabolism]; Region:
CaiA; COG1960"
/db_xref="CDD:224871"
misc_feature complement(order(354978..354980,354984..354986,
355056..355061,355074..355079,355083..355085))
/gene="fadE6"
/locus_tag="BCG_0309c"
/note="FAD binding site [chemical binding]; other site"
/db_xref="CDD:173841"
misc_feature complement(order(354327..354329,354360..354365,
354912..354914,355056..355058))
/gene="fadE6"
/locus_tag="BCG_0309c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173841"
misc_feature complement(354729..354731)
/gene="fadE6"
/locus_tag="BCG_0309c"
/note="catalytic base [active]"
/db_xref="CDD:173841"
gene complement(356606..357739)
/locus_tag="BCG_0310c"
/db_xref="GeneID:4696257"
CDS complement(356606..357739)
/locus_tag="BCG_0310c"
/note="Differs from Mb0278c by 1aa, P164L"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976408.1"
/db_xref="GI:121636185"
/db_xref="GeneID:4696257"
/translation="MTGRAATPGVIREFVGLPSRTAGRAAAGGHPCQGLYHHSVGRKP
KVALIAAHYQIDFSEHYLAEYMAIRGIGFLGWNTRFRGFESSFLLDHALVDIGVGVRW
LREVQGVETVVLLGNSGGGSLMAAYQSQAVDPNVTPLDGMRPAAGVTELPAADAYVAA
AAHPGRPDVLTAWMDAAVIDENDPVATDPELDLFDERNGPPYSPEFISRYRSAQVKRN
HTITDWAESELKRVRAAGFSDRPFSVMRTWADPRMVDPSIEPTKRRPNQCYAGTPVKA
NRSAHGIAAACTLRGWLGMWSLRVAQTRAAPHLARITCPALVLNAEADTGIFPSDAQQ
IYDGLASSDKTQVSIDTDHYFTTPGARSEQADTIAKWIAKRWR"
misc_feature complement(356627..>356875)
/locus_tag="BCG_0310c"
/note="Alpha/beta hydrolase family; Region: Abhydrolase_6;
pfam12697"
/db_xref="CDD:221720"
gene complement(357736..358356)
/locus_tag="BCG_0311c"
/db_xref="GeneID:4697726"
CDS complement(357736..358356)
/locus_tag="BCG_0311c"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976409.1"
/db_xref="GI:121636186"
/db_xref="GeneID:4697726"
/translation="MPDFPTQRGRRTQAAIDAAARTVVVRNGILATTVADITAEAGRS
AASFYNYYDSKEAMVRQWALRFRDDANQRALSVIRHGLSDRERAYEAAAAHWYTYRNR
LAEAISVSQLAMVSDDFAQYWSEICQIPISFITETVKRAQAHGYCVGDDPQLMAEAIV
AMFNQFCYLQLSGKRSRRGQPDDQACIQTLANIYYRAIYSKEDSSN"
misc_feature complement(357868..358344)
/locus_tag="BCG_0311c"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature complement(358177..358305)
/locus_tag="BCG_0311c"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 358453..359034
/locus_tag="BCG_0312"
/db_xref="GeneID:4697690"
CDS 358453..359034
/locus_tag="BCG_0312"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976410.1"
/db_xref="GI:121636187"
/db_xref="GeneID:4697690"
/translation="MIKPHNTNTEFELGGINHVALVCSDMARTVDFYSNILGMPLIKA
LDLPGGQGQHFFFDAGNGDCVAFFWFADAPDRVPGLSSPVAIPGIGDITSAVSTMNHL
AFHVPAERFDAYRQRLKDKGVRVGPVLNHDDSETQVSAVVHPGVYVRSFYFQDPDGIT
LEFACWTKEFTTSDAQAVPKTAADRRPPVAADR"
misc_feature 358495..358944
/locus_tag="BCG_0312"
/note="N-terminal domain of Sphingobium chlorophenolicum
2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and
similar proteins; Region: PcpA_N_like; cd08346"
/db_xref="CDD:211356"
misc_feature 358495..358941
/locus_tag="BCG_0312"
/note="Glyoxalase/Bleomycin resistance protein/Dioxygenase
superfamily; Region: Glyoxalase; pfam00903"
/db_xref="CDD:216182"
misc_feature order(358504..358506,358510..358512)
/locus_tag="BCG_0312"
/note="Zn binding site [ion binding]; other site"
/db_xref="CDD:211356"
gene complement(358964..359689)
/locus_tag="BCG_0313c"
/db_xref="GeneID:4699312"
CDS complement(358964..359689)
/locus_tag="BCG_0313c"
/note="Differs from Rv0275c by 1aa, L24S"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976411.1"
/db_xref="GI:121636188"
/db_xref="GeneID:4699312"
/translation="MTRSDRPYRGVEAAERLATRRRQLLSAGLDLLGSDQHDIAELTI
RTICRRAGLSVRYFYESFTDKDEFVGRVFDWVVAELVATTQAAVTAVPAREQTRAGMA
NIVRTITADARVGRLLFSTQLANAVITRKRAESSALFAMLSGQHAVDTLHAPANDHVK
AVAHFAVGGVGQTISAWLAGDVRLDPDQLVDQLAALLDELTDPNLSRPRVAATAAKSG
ANDPQPPEVAGQPPSSARPARRS"
gene 359779..360699
/locus_tag="BCG_0314"
/db_xref="GeneID:4697725"
CDS 359779..360699
/locus_tag="BCG_0314"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976412.1"
/db_xref="GI:121636189"
/db_xref="GeneID:4697725"
/translation="MAISLVAHQPIPHVERPMADPPRLQLARRRRSAAGPGGNEDSLM
GVALLAGPANVIMELAMPGVGYGVLESRVESGRLDRHPIKRARTTFTYVAVAVAGSDD
QKAAFRRAVNKVHAQVYSTPESPVSYHAFDPELQLWVAACLYKGGVDVYRTFVGEMDD
EEADHHYRAGMAMGTTLQVPPQMWPPDRAAFDRYWRQSLDRVHIDDVVRDYLYPIVAL
RIRGIALPGPLRRLSEGIALLITTGFLPQRFRDEMRLPWDATKQRRFDALMAVLRTVN
RLMPRFVREFPFNLMLWDLDRRMRRGRPLV"
misc_feature 359779..360645
/locus_tag="BCG_0314"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG3662"
/db_xref="CDD:226188"
gene complement(360739..361167)
/locus_tag="BCG_0315c"
/db_xref="GeneID:4696359"
CDS complement(360739..361167)
/locus_tag="BCG_0315c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976413.1"
/db_xref="GI:121636190"
/db_xref="GeneID:4696359"
/translation="MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVW
ASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHLPTSPGPRHLVLLRKLCDEADAS
GDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI"
misc_feature complement(360745..361167)
/locus_tag="BCG_0315c"
/note="Mycobacterium tuberculosis PIN domain family;
Region: Mtu_PIN_fam; TIGR00028"
/db_xref="CDD:232790"
misc_feature complement(order(360790..360792,360844..360846,
361153..361155))
/locus_tag="BCG_0315c"
/note="putative active site [active]"
/db_xref="CDD:189022"
gene complement(361191..361448)
/locus_tag="BCG_0315A"
/db_xref="GeneID:4697964"
CDS complement(361191..361448)
/locus_tag="BCG_0315A"
/note="Differs by 1 aa, Q24* from Rv0227A and Mb0351A"
/codon_start=1
/transl_table=11
/product="antitoxin"
/protein_id="YP_976414.1"
/db_xref="GI:121636191"
/db_xref="GeneID:4697964"
/translation="MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTG
GARPTVPVFDAGTGPRPGIDLTSNRVLSEVLDEGLELNSRK"
gene complement(361468..361710)
/gene="PE_PGRS3b"
/locus_tag="BCG_0316c"
/pseudo
/db_xref="GeneID:4695664"
gene complement(361533..364283)
/gene="PE_PGRS3a"
/locus_tag="BCG_0317c"
/db_xref="GeneID:4697094"
CDS complement(361533..364283)
/gene="PE_PGRS3a"
/locus_tag="BCG_0317c"
/note="In Mycobacterium tuberculosis strain H37Rv,
PE_PGRS3 exists as a single gene. In Mycobacterium bovis
and Mycobacterium bovs BCG Pasteur, a large insertion
leads to an extra copy of PE_PGRS3. Also, a frameshift due
to single base deletion (t-*), splits this extra copy of
PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Also
differs from Mb0285c by an insertion of 144bp"
/codon_start=1
/transl_table=11
/product="PE-PGRS family protein"
/protein_id="YP_976415.1"
/db_xref="GI:121636192"
/db_xref="GeneID:4697094"
/translation="MSFVIAAPEVIAAAATDLASLESSIAAANAAAAANTTALLAAGA
DEVSTAVAALFGAHGQAYQALSAQAQAFHAQFTQALTSGGGAYAAAEAAATSPLLAPI
NEFFLANTGRPLIGNGANGAPGTGADGAPGGWLIGNGGAGGSGAANNAVGGTGGTGGA
GGASGLLGSGGAGGAGGVATNTGGIGGAGGTGGNAVLFGAGGAGGASTNTTGGAGGAG
GDGGNAGLLFGAAGVGGAGGFALATTASGGAGGAGGAGGMFTDGGVGGVGGKGGFGGA
GGAGGNGGLFGAGGTGGAGGTIGAGVAGMGGAGGAGGAGGLFGAGGTGGSGGGGATTG
GDGGAGGNAGTLSLGAAGGAGGAGGEGLASAGGDGGAGGDGGNAGMFFGSGGAGGAGG
FGRTTGGIGGTGGNAGLLNGSGGAGGAGGAAITGPGGTGGAGGIPGLIGNGGNGGDGG
ASVTGTGGNGGAGGNGVQIGNGGNGGSGGTGAAAGKAGLGGLGGQLIGLDGSNAPVST
SVHTLQQAALNVVNEPFQTLTGRPLIGNGANGTPGTGAAGGAGGWLFGNGGNGGHGAT
NTAATATGGAGGAGGILFGTGGNGGTGGIATGAGGIGGAGGAGGVSLLIGSGGTGGNG
GNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPAGVGGAGGNGGLFANGGAGG
AGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGGLFGAGGTGGAAGSGGSGIT
TGGGGHGGNAGLLSLGASGGAGGSGGASSLAGGAGGTGGNGALLFGFGGAGGAGGHGG
AALTSIQQGGAGGAGGNGGLLFGSAGAGGAGGSGANALGAGTGGTGGDGGHAGVFGNG
GDGGAGGFGAGTGGSGGVGGNAVLIGNGGNGGNAGKAGATPGAGGTGGLLLGENGLNG
LP"
misc_feature complement(<364107..364283)
/gene="PE_PGRS3a"
/locus_tag="BCG_0317c"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
misc_feature 362672..365595
/note="I-RD01, 2924 bp. Region of Difference I-RDXXXX,
inserted region in Mycobacterium bovis BCG Pasteur
(position 362672..365595, 2924bp) and Mycobacterium bovis
AF2122/97 (position 332966..335745, 2780 bp) compared to
Mycobacterium tuberculosis H37Rv2 (position:
334641..334642). Duplicates PE_PGRS3"
gene complement(364547..367246)
/gene="PE_PGRS3"
/locus_tag="BCG_0318c"
/db_xref="GeneID:4697093"
CDS complement(364547..367246)
/gene="PE_PGRS3"
/locus_tag="BCG_0318c"
/note="In Mycobacterium bovis BCG Pasteur, a insertion of
66 bp lead to a longer product than to the homolog
Mycobacterium bovis (899 aa versus 877 aa). In
Mycobacterium bovis, 2 deletions, one of 18 bp and the
other of 66 bp, and part of a 2780 bp insertion , leads to
a shorter product with a different 3' end compared to its
homolog in Mycobacterium tuberculosis strain H37Rv (877 aa
versus 957 aa)"
/codon_start=1
/transl_table=11
/product="PE-PGRS family protein"
/protein_id="YP_976416.1"
/db_xref="GI:121636193"
/db_xref="GeneID:4697093"
/translation="MSFVIAAPEVIAAAATDLASLGSSISAANAAAAANTTALMAAGA
DEVSTAIAALFGAHGQAYQALSAQAQAFHAQFVQALTSGGGAYAAAEAAAVSPLLDPI
NEFFLANTGRPLIGNGANGAPGTGANGGDGGWLIGNGGAGGSGAAGVNGGAGGNGGAG
GLIGNGGAGGAGGVASSGIGGSGGAGGNAMLFGAGGAGGAGGGVVALTGGAGGAGGAG
GNAGLLFGAAGVGGAGGFTNGSALGGAGGAGGAGGLFATGGVGGSGGAGSSGGAGGAG
GAGGLFGAGGTGGHGGFADSSFGGVGGAGGAGGLFGAGGEGGSGGHSLVAGGDGGAGG
NAGMLALGAAGGAGGIGGDGGTLTAGGIGGAGGAGGNAGLLFGSGGSGGAGGFGFADG
GQGGPGGNAGTVFGSGGAGGNGGVGQGFAGGIGGAGGTPGLIGNGGNGGNGGASAVTG
GNGGIGGTGVLIGNGGNGGSGGIGAGKAGVGGVSGLLLGLDGFNAPASTSPLHTLQQN
VLNVVNEPFQTLTGRPLIGNGANGTPGTGADGGAGGWLFGNGGNGGSGATGTNGGDGG
DGGAGGIFFGTGGTGGAGGVGTTGTGGDGGAGGAAFLVGSGGNGGSGGAGLTAGGDGG
DGGNAGSFFGAAGTGGAGASTKAGGTGGTGGNGGLFANGGAGGSGGLGGDAGTGGAGG
NGGLFGAGGTGGAGGSLGPGAGGAGGNGGLFGAGGTGGSGGHGTPAAVPGGAGGAGGN
AGLFSLGASGGAGGSGGSSLTDSGGIGGVGGAGGLLFGYGGAGGAGGYSNIGAGGAGG
AGGNAGMLSGSGGSGGTGGASGAAKGGVGGNGGTAGVFGNGGDGGAGGFGAGTGGNGG
VGGNAVLIGNGGNGGNGGKAGGTPGAGGTSGLLIGENGLNGLP"
misc_feature complement(<367070..>367114)
/gene="PE_PGRS3"
/locus_tag="BCG_0318c"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
gene complement(367496..370000)
/gene="PE_PGRS4"
/locus_tag="BCG_0319c"
/db_xref="GeneID:4696182"
CDS complement(367496..370000)
/gene="PE_PGRS4"
/locus_tag="BCG_0319c"
/note="In Mycobacterium bovis BCG Pasteur, 2 insertions
each of 9 bp and a deletion of 9bp, lead to a longer
product compared to its homolog in Mycobacterium bovis
(834 aa versus 831 aa). In Mycobacterium bovis, 2
deletions each of 9 bp (ccgccggcg-* and cccgccggc-*),
leads to a shorter product compared to its homolog in
Mycobacterium tuberculosis strain H37Rv (831 aa versus 837
aa)"
/codon_start=1
/transl_table=11
/product="PE-PGRS family protein"
/protein_id="YP_976417.1"
/db_xref="GI:121636194"
/db_xref="GeneID:4696182"
/translation="MSFVIAAPEVIAAAATDLASLESSIAAANAAAAANTTALLAAGA
DEVSTAVAALFGAHGQAYQALSAQAQAFHAQFVQALTSGGGAYAAAEAAATSPLLAPI
NEFFLANTGRPLIGNGANGAPGTGADGAPGGWLIGNGGAGGSGAAGVNGGAGGNGGAG
GLIGNGGAGGAGGRASTGTGGAGGAGGAAGMLFGAAGVGGPGGFAAAFGATGGAGGAG
GNGGLFADGGVGGAGGATDAGTGGAGGSGGNGGLFGAGGTGGPGGFGIFGGGAGGDGG
SGGLFGAGGTGGSGGTSIINVGGNGGAGGDAGMLSLGAAGGAGGSGGSSPDGGGGAGG
IGGDGGTLFGSGGVGGLGFDAGGAGGAGGKAGLLSGAGGAGGAGGGSFAGAGGTGGAG
GAPGLVGNAGNGGNGGASANGAGAAGGAGGSGVLIGNGGNGGSGGTGAPAGTAGAGGL
GGQLLGRDGFNAPASTPLHTLQQQILNAINEPTQALTGRPLIGNGANGTPGTGADGGA
GGWLFGNGGNGGHGATGADGGDGGSGGAGGILSGIGGTGGSGGIGTTGQGGTGGTGGA
ALLIGSGGTGGSGGFGLDTGGAGGRGGDAGLFLGAAGTGGQAALSQNFIGAGGTAGAG
GTGGLFANGGAGGAGGFGANGGTGGNGLLFGAGGTGGAGTLGADGGAGGHGGLFGAGG
TGGAGGSSGGTFGGNGGSGGNAGLLALGASGGAGGSGGSALNVGGTGGVGGNGGSGGS
LFGFGGAGGTGGSSGIGSSGGTGGDGGTAGVFGNGGDGGAGGFGTGAGGTGGTGGNAV
LIGNGGNGGNGGKAGGTPGAGGTSGLIIGENGLNGL"
misc_feature complement(<369824..370000)
/gene="PE_PGRS4"
/locus_tag="BCG_0319c"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
gene 370291..371901
/gene="PPE3"
/locus_tag="BCG_0320"
/db_xref="GeneID:4697095"
CDS 370291..371901
/gene="PPE3"
/locus_tag="BCG_0320"
/note="Differs from Rv0280 by 1 aa P337S"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976418.1"
/db_xref="GI:121636195"
/db_xref="GeneID:4697095"
/translation="MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAEYAAVAD
ELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAAARHETVAAAYTTAV
AAMPTLVELAANHTLHGVLVATNFFGINTIPIALNEADYARMWTQAASTMATYQAVAE
AAVASAPQTTPAPPILAAEAADDDHDHDHDHGGEPTPLDYLVAEILRIISGGRLIWDP
AEGTMNGIPFEDYTDAAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFD
YPTHIVQIVEALSQSPQLLAVALGSVISNLGAVTGFAGLSGLAGMQPAAIPALAPVAA
APPTLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPAPPPAPGAAGFGYPYAI
APPGIGFGSGMSASASAQRKAPQPDSAAAAAAAAAVRDQARARRRRRVTRRGYGDEFM
DMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLGFAGTARREAVADAAGMTTLAGDDFG
DGPTTPMVPGSWDPDRDAPGSAEPGDRG"
misc_feature 370300..>371256
/gene="PPE3"
/locus_tag="BCG_0320"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:35210"
misc_feature 370306..370737
/gene="PPE3"
/locus_tag="BCG_0320"
/note="PPE family; Region: PPE; pfam00823"
/db_xref="CDD:189731"
misc_feature <371701..371862
/gene="PPE3"
/locus_tag="BCG_0320"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:35210"
gene 371925..372833
/locus_tag="BCG_0321"
/db_xref="GeneID:4697685"
CDS 371925..372833
/locus_tag="BCG_0321"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976419.1"
/db_xref="GI:121636196"
/db_xref="GeneID:4697685"
/translation="MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAF
CRAVGGSWADVLDGKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAAAAGARQVVI
LAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHGAQPRALRREIAVDLRDDW
PQALRDSGFDAAAPSAWIAEGLLIYLPATAQERLFTGIDALAGRRSHVAVEDGAPMGP
DEYAAKVEEERAAIAEGAEEHPFFQLVYNERCAPAAEWFGERGWTAVATLLNDYLEAV
GRPVPGPESEAGPMFARNTLVSAARV"
misc_feature 371925..372827
/locus_tag="BCG_0321"
/note="O-Methyltransferase involved in polyketide
biosynthesis [Secondary metabolites biosynthesis,
transport, and catabolism]; Region: COG3315"
/db_xref="CDD:225852"
misc_feature 371967..372761
/locus_tag="BCG_0321"
/note="methyltransferase, TIGR00027 family; Region:
mthyl_TIGR00027"
/db_xref="CDD:232789"
gene 373058..374953
/locus_tag="BCG_0322"
/db_xref="GeneID:4697218"
CDS 373058..374953
/locus_tag="BCG_0322"
/note="Differs from Rv0282 by 1aa, A6E"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976420.1"
/db_xref="GI:121636197"
/db_xref="GeneID:4697218"
/translation="MAGVGAGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATC
CRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRT
ATTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKA
NHVVSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKIT
LGTALARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYA
AHPENEQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALL
HEAELQLAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKT
TIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEA
YALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTR
NIDFPSYTSHELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSL
DIAGNGRFVRNIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRG
LGLSVRA"
misc_feature 373259..374926
/locus_tag="BCG_0322"
/note="type VII secretion AAA-ATPase EccA; Region:
T7SS_EccA; TIGR03922"
/db_xref="CDD:188437"
misc_feature 374138..374599
/locus_tag="BCG_0322"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature 374210..374233
/locus_tag="BCG_0322"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature order(374213..374236,374399..374401,374519..374521)
/locus_tag="BCG_0322"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature 374387..374404
/locus_tag="BCG_0322"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature 374570..374572
/locus_tag="BCG_0322"
/note="arginine finger; other site"
/db_xref="CDD:99707"
gene 374950..376566
/locus_tag="BCG_0323"
/db_xref="GeneID:4697294"
CDS 374950..376566
/locus_tag="BCG_0323"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976421.1"
/db_xref="GI:121636198"
/db_xref="GeneID:4697294"
/translation="MTNQQHDHDFDHDRRSFASRTPVNNNPDKVVYRRGFVTRHQVTG
WRFVMRRIAAGIALHDTRMLVDPLRTQSRAVLMGVLIVITGLIGSFVFSLIRPNGQAG
SNAVLADRSTAALYVRVGEQLHPVLNLTSARLIVGRPVSPTTVKSTELDQFPRGNLIG
IPGAPERMVQNTSTDANWTVCDGLNAPSRGGADGVGVTVIAGPLEDTGARAAALGPGQ
AVLVDSGAGTWLLWDGKRSPIDLADHAVTSGLGLGADVPAPRIIASGLFNAIPEAPPL
TAPIIPDAGNPASFGVPAPIGAVVSSYALKDSGKTISDTVQYYAVLPDGLQQISPVLA
AILRNNNSYGLQQPPRLGADEVAKLPVSRVLDTRRYPSEPVSLVDVTRDPVTCAYWSK
PVGAATSSLTLLAGSALPVPDAVHTVELVGAGNGGVATRVALAAGTGYFTQTVGGGPD
APGAGSLFWVSDTGVRYGIDNEPQGVAGGGKAVEALGLNPPPVPIPWSVLSLFVPGPT
LSRADALLAHDTLVPDSRPARPVSAEGGYR"
misc_feature 375043..376524
/locus_tag="BCG_0323"
/note="Protein of unknown function (DUF690); Region:
DUF690; pfam05108"
/db_xref="CDD:218438"
gene 376563..380555
/locus_tag="BCG_0324"
/db_xref="GeneID:4696654"
CDS 376563..380555
/locus_tag="BCG_0324"
/note="Differs from Mb0292 by 1aa, A134T, and from Rv0284
by 2aa, A134T, R214P"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976422.1"
/db_xref="GI:121636199"
/db_xref="GeneID:4696654"
/translation="MSRLIFEARRRLAPPSSHQGTIIIEAPPELPRVIPPSLLRRALP
YLIGILIVGMIVALVATGMRVISPQTLFFPFVLLLAATALYRGNDKKMRTEEVDAERA
DYLRYLSVVRDNIRAQAAEQRASALWSHPDPAALASVPGSRRQWERDPHDPDFLVLRA
GRHTVPLATTLRVNDTADEIDLEPVSHSALRSLLDTQRSIGDVPTGIDLTKVSRITVL
GERAQVRAVLRAWIAQAVTWHDPTVLGVALAARDLEGRDWNWLKWLPHVDIPGRLDAL
GPARNLSTDPDELIALLGPVLADRPAFTGQPTDALRHLLIVVDDPDYDLGASPLAVGR
AGVTVVHCSASAPHREQYSDPEKPILRVAHGAIERWQTGGWQPYIDAADQFSADEAAH
LARRLSRWDSNPTHAGLRSAATRGASFTTLLGIEDASRLDVPALWAPRRRDEELRVPI
GVTGTGEPLMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSAERLIVI
YADFKGEAGADSFRDFPQVVAVISNMAEKKSLADRFADTLRGEVARREMLLREAGRKV
QGSAFNSVLEYENAIAAGHSLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSF
RIHILFASQTLDVGKIKDIDKNTAYRIGLKVASPSVSRQIIGVEDAYHIESGKEHKGV
GFLVPAPGATPIRFRSTYVDGIYEPPQTAKAVVVQSVPEPKLFTAAAVEPDPGTVIAD
TDEQEPADPPRKLIATIGEQLARYGPRAPQLWLPPLDETIPLSAALARAGVGPRQWRW
PLGEIDRPFEMRRDPLVFDARSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPHEVS
FYCLDYGGGQLRALQDLAHVGSVASALEPERIRRTFGELEQLLLSRQQREVFRDRGAN
GSTPDDGFGEVFLVIDNLYGFGRDNTDQFNTRNPLLARVTELVNVGLAYGIHVIITTP
SWLEVPLAMRDGLGLRLELRLHDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHF
LFAAPELDAQTNPVAAINARYPGMAAPPVRLLPTNLAPHAVGELYRGPDQLVIGQREE
DLAPVILDLAANPLLMVFGDARSGKTTLLRHIIRTVREHSTADRVAFTVLDRRLHLVD
EPLFPDNEYTANIDRIIPAMLGLANLIEARRPPAGMSAAELSRWTFAGHTHYLIIDDV
DQVPDSPAMTGPYIGQRPWTPLIGLLAQAGDLGLRVIVTGRATGSAHLLMTSPLLRRF
NDLQATTLMLAGNPADSGKIRGERFARLPAGRAILLTDSDSPTYVQLINPLVDAAAVS
GETQQKGSQS"
misc_feature 376668..378677
/locus_tag="BCG_0324"
/note="type VII secretion protein EccCa; Region:
T7SS_EccC_a; TIGR03924"
/db_xref="CDD:213878"
misc_feature 377880..378473
/locus_tag="BCG_0324"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:214148"
misc_feature 378816..380489
/locus_tag="BCG_0324"
/note="type VII secretion protein EccCb; Region:
T7SS_EccC_b; TIGR03925"
/db_xref="CDD:188440"
misc_feature 378912..379664
/locus_tag="BCG_0324"
/note="FtsK/SpoIIIE family; Region: FtsK_SpoIIIE;
pfam01580"
/db_xref="CDD:190044"
misc_feature 379794..>379979
/locus_tag="BCG_0324"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:214148"
gene 380552..380860
/gene="PE5"
/locus_tag="BCG_0325"
/db_xref="GeneID:4698280"
CDS 380552..380860
/gene="PE5"
/locus_tag="BCG_0325"
/codon_start=1
/transl_table=11
/product="PE family protein"
/protein_id="YP_976423.1"
/db_xref="GI:121636200"
/db_xref="GeneID:4698280"
/translation="MTLRVVPEGLAAASAAVEALTARLAAAHASAAPVITAVVPPAAD
PVSLQTAAGFSAQGVEHAVVTAEGVEELGRAGVGVGESGASYLAGDAAAAATYGVVGG
"
gene 380863..382404
/gene="PPE4"
/locus_tag="BCG_0326"
/db_xref="GeneID:4696202"
CDS 380863..382404
/gene="PPE4"
/locus_tag="BCG_0326"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976424.1"
/db_xref="GI:121636201"
/db_xref="GeneID:4696202"
/translation="MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYAST
AAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTT
ALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAA
SGAALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQL
IWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSP
FLLPAGLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAG
AATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVP
AAAAAAATRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLG
FAGTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGL
PHDSK"
misc_feature 380872..>381429
/gene="PPE4"
/locus_tag="BCG_0326"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:227938"
misc_feature 380884..381336
/gene="PPE4"
/locus_tag="BCG_0326"
/note="PPE family; Region: PPE; pfam00823"
/db_xref="CDD:216138"
gene 382453..382746
/gene="esxG"
/locus_tag="BCG_0327"
/db_xref="GeneID:4697818"
CDS 382453..382746
/gene="esxG"
/locus_tag="BCG_0327"
/standard_name="TB9.8"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976425.1"
/db_xref="GI:121636202"
/db_xref="GeneID:4697818"
/translation="MSLLDAHIPQLVASQSAFAAKAGLMRHTIGQAEQAAMSAQAFHQ
GESSAAFQAAHARFVAAAAKVNTLLDVAQANLGEAAGTYVAADAAAASTYTGF"
gene 382776..383066
/gene="esxH"
/locus_tag="BCG_0328"
/db_xref="GeneID:4698781"
CDS 382776..383066
/gene="esxH"
/locus_tag="BCG_0328"
/standard_name="cfp7; TB10.4"
/codon_start=1
/transl_table=11
/product="low molecular weight protein antigen 7 cfp7"
/protein_id="YP_976426.1"
/db_xref="GI:121636203"
/db_xref="GeneID:4698781"
/translation="MSQIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQ
GDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAMMARDTAEAAKWGG"
misc_feature 382776..383063
/gene="esxH"
/locus_tag="BCG_0328"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG4842"
/db_xref="CDD:227179"
gene 383077..383964
/locus_tag="BCG_0329"
/db_xref="GeneID:4698809"
CDS 383077..383964
/locus_tag="BCG_0329"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976427.1"
/db_xref="GI:121636204"
/db_xref="GeneID:4698809"
/translation="MDATPNAVELTVDNAWFIAETIGAGTFPWVLAITMPYSDAAQRG
AFVDRQRDELTRMGLLSPQGVINPAVADWIKVVCFPDRWLDLRYVGPASADGACELLR
GIVALRTGTGKTSNKTGNGVVALRNAQLVTFTAMDIDDPRALVPILGVGLAHRPPARF
DEFSLPTRVGARADERLRSGVPLGEVVDYLGIPASARPVVESVFSGPRSYVEIVAGCN
RDGRHTTTEVGLSIVDTSAGRVLVSPSRAFDGEWVSTFSPGTPFAIAVAIQTLTACLP
DGQWFPGQRVSRDFSTQSS"
misc_feature 383104..383889
/locus_tag="BCG_0329"
/note="EspG family; Region: ESX-1_EspG; pfam14011"
/db_xref="CDD:222494"
gene 384011..385429
/locus_tag="BCG_0330"
/db_xref="GeneID:4698139"
CDS 384011..385429
/locus_tag="BCG_0330"
/note="Differs from Rv0290 by 1aa, T400A"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976428.1"
/db_xref="GI:121636205"
/db_xref="GeneID:4698139"
/translation="MSGTVMQIVRVAILADSRLTEMALPAELPLREILPAVQRLVVPS
AQNGDGGQADSGAAVQLSLAPVGGQPFSLDASLDTVGVVDGDLLVLQPVPAGPAAPGI
VEDIADAAMIFSTSRLKPWGIAHIQRGALAAVIAVALLATGLTVTYRVATGVLAGLLA
VAGIAVASALAGLLITIRSPRSGIALSIAALVPIGAALALAVPGKFGPAQVLLGAAGV
AAWSLIALMIPSAERERVVAFFTAAAVVGASVALAAGAQLLWQLPLLSIGCGLIVAAL
LVTIQAAQLSALWARFPLPVIPAPGDPTPSAPPLRLLEDLPRRVRVSDAHQSGFIAAA
VLLSVLGSVAIAVRPEALSVVGWYLVAATAAAATLRARVWDSAACKAWLLAQPYLVAG
VLLVFYTTTGRYVAAFGAVLVLAVLMLAWVVVALNPGIASPESYSLPLRRLLGLVAAG
LDVSLIPVMAYLVGLFAWVLNR"
misc_feature 384041..385207
/locus_tag="BCG_0330"
/note="Ubiquitin-like proteins; Region: UBQ; cl00155"
/db_xref="CDD:214027"
gene 385426..386811
/locus_tag="BCG_0331"
/db_xref="GeneID:4699096"
CDS 385426..386811
/locus_tag="BCG_0331"
/EC_number="3.4.-.-"
/codon_start=1
/transl_table=11
/product="protease"
/protein_id="YP_976429.1"
/db_xref="GI:121636206"
/db_xref="GeneID:4699096"
/translation="MIRAAFACLAATVVVAGWWTPPAWAIGPPVVDAAAQPPSGDPGP
VAPMEQRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQLVAIIDTGVQPGP
RLPNVDAGGDFVESTDGLTDCDGHGTLVAGIVAGQPGNDGFSGVAPAARLLSIRAMST
KFSPRTSGGDPQLAQATLDVAVLAGAIVHAADLGAKVINVSTITCLPADRMVDQAALG
AAIRYAAVDKDAVIVAAAGNTGASGSVSASCDSNPLTDLSRPDDPRNWAGVTSVSIPS
WWQPYVLSVASLTSAGQPSKFSMPGPWVGIAAPGENIASVSNSGDGALANGLPDAHQK
LVALSGTSYAAGYVSGVAALVRSRYPGLNATEVVRRLTATAHRGARESSNIVGAGNLD
AVAALTWQLPAEPGGGAAPAKPVADPPVPAPKDTTPRNVAFAGAAALSVLVGLTAATV
AIARRRREPTE"
misc_feature 385645..386550
/locus_tag="BCG_0331"
/note="Peptidase domain in the S8 and S53 families;
Region: Peptidases_S8_S53; cl10459"
/db_xref="CDD:245304"
misc_feature 385648..386628
/locus_tag="BCG_0331"
/note="type VII secretion-associated serine protease
mycosin; Region: T7SS_mycosin; TIGR03921"
/db_xref="CDD:234398"
misc_feature order(385801..385803,386041..386043,386449..386451)
/locus_tag="BCG_0331"
/note="active site"
/db_xref="CDD:173787"
misc_feature order(385801..385803,386449..386451)
/locus_tag="BCG_0331"
/note="catalytic residues [active]"
/db_xref="CDD:173787"
gene 386808..387803
/locus_tag="BCG_0332"
/db_xref="GeneID:4698120"
CDS 386808..387803
/locus_tag="BCG_0332"
/note="Differs from Rv0292 by 1aa, D217N"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976430.1"
/db_xref="GI:121636207"
/db_xref="GeneID:4698120"
/translation="MNPIPSWPGRGRVTLVLLAVVPVALAYPWQSTRDYVLLGVAAAV
VIGLFGFWRGLYFTTIARRGLAILRRRRRIAEPATCTRTTVLVWVGPPASDTNVLPLT
LIARYLDRYGIRADTIRITSRVTASGDCRTWVGLTVVADDNLAALQARSARIPLQETA
QVAARRLADHLREIGWEAGTAAPDEIPALVAADSRETWRGMRHTDSDYVAAYRVSADA
ELPDTLPAIRSRPAQETWIALEIAYAAGSSTRYTVAAACALRTDWRPGGTAPVAGLLP
QHGNHVPALTALDPRSTRRLDGHTDAPADLLTRLHWPTPTAGAHRAPLTNAVSRT"
misc_feature <387042..387692
/locus_tag="BCG_0332"
/note="type VII secretion protein EccE; Region: T7SS_EccE;
TIGR03923"
/db_xref="CDD:234399"
gene complement(387790..388992)
/locus_tag="BCG_0333c"
/db_xref="GeneID:4695810"
CDS complement(387790..388992)
/locus_tag="BCG_0333c"
/note="Differs from Rv0293c and Mb0301c by 1aa, S263G"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976431.1"
/db_xref="GI:121636208"
/db_xref="GeneID:4695810"
/translation="MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVE
SSAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSF
PAPTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQ
HWRHRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFS
PFSGFGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTSISLGGYTSALLAS
VESRLEAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYR
PLLPKDRRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTV
FLQGLMFD"
misc_feature complement(387826..388470)
/locus_tag="BCG_0333c"
/note="Alpha/beta hydrolase family; Region: Abhydrolase_6;
pfam12697"
/db_xref="CDD:205026"
misc_feature complement(387814..>388404)
/locus_tag="BCG_0333c"
/note="Esterases and lipases (includes fungal lipases,
cholinesterases, etc.) These enzymes act on carboxylic
esters (EC: 3.1.1.-). The catalytic apparatus involves
three residues (catalytic triad): a serine, a glutamate or
aspartate and a histidine.These...; Region:
Esterase_lipase; cl12031"
/db_xref="CDD:214205"
gene 389099..389884
/gene="tam"
/locus_tag="BCG_0334"
/db_xref="GeneID:4696893"
CDS 389099..389884
/gene="tam"
/locus_tag="BCG_0334"
/EC_number="2.1.1.-"
/note="catalyzes the formation of
(E)-3-(methoxycarbonyl)pent-2-enedioate and
S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and
trans-aconitate"
/codon_start=1
/transl_table=11
/product="trans-aconitate 2-methyltransferase"
/protein_id="YP_976432.1"
/db_xref="GI:121636209"
/db_xref="GeneID:4696893"
/translation="MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLT
RYLARRWPGAVIEALDSSPEMVAAAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWV
PEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGA
VVQSPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDESWQ
QFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG"
misc_feature 389099..389863
/gene="tam"
/locus_tag="BCG_0334"
/note="Trans-aconitate methyltransferase [General function
prediction only]; Region: Tam; COG4106"
/db_xref="CDD:226591"
misc_feature 389192..389476
/gene="tam"
/locus_tag="BCG_0334"
/note="S-adenosylmethionine-dependent methyltransferases
(SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
that use S-adenosyl-L-methionine (SAM or AdoMet) as a
substrate for methyltransfer, creating the product
S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
cd02440"
/db_xref="CDD:100107"
misc_feature order(389204..389224,389276..389281,389333..389341,
389384..389386)
/gene="tam"
/locus_tag="BCG_0334"
/note="S-adenosylmethionine binding site [chemical
binding]; other site"
/db_xref="CDD:100107"
gene complement(389873..390676)
/locus_tag="BCG_0335c"
/db_xref="GeneID:4696339"
CDS complement(389873..390676)
/locus_tag="BCG_0335c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976433.1"
/db_xref="GI:121636210"
/db_xref="GeneID:4696339"
/translation="MSRAVRPYLVLATQRSGSTLLVESLRATGCAGEPQEFFQYLPST
GMAPQPREWFAGVDDDTILQLLDPLDPGTPDTATPVAWREHVRTSGRTPNGVWGGKLM
WNQTALLQQRAAQLPDRSGDGLRAAIRDVIGNEPVFVHVHRPDVVSQAVSFWRAVQTQ
VWRGHPDPKRDSQAVYHAGAIAHIIRNLRDQENGWRAWFAEEGIDPIDIAYPVLWRNL
TAIVASVLDAIGQDPKLAPAPMLERQANQRSDEWVDRYRAEAPRLGLPT"
misc_feature complement(389876..390676)
/locus_tag="BCG_0335c"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG4424"
/db_xref="CDD:226848"
gene complement(390686..392083)
/locus_tag="BCG_0336c"
/db_xref="GeneID:4697957"
CDS complement(390686..392083)
/locus_tag="BCG_0336c"
/EC_number="3.-.-.-"
/codon_start=1
/transl_table=11
/product="sulfatase"
/protein_id="YP_976434.1"
/db_xref="GI:121636211"
/db_xref="GeneID:4697957"
/translation="MTSERATGQRENLLIVHWHDLGRYLGVYHHPDVYSPRLDRLAAE
GILFTRAHATAPLCTPSRGSLFTGRYPQSNGLVGLAHHGWEYRTGVQTLPQLLSESGW
YSALFGMQHETSYPKRLGFDEFDVSNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGF
FETHRPYPHERYRPADSAAVELPDYLPDTPEVRQDVAEFYGSIATADEAVGRLLDTLA
DTGLDASTWVVFVTDHGPAFPRAKSTLYDAGTGIALIIRPPTRRAMAPRVYDELFSGV
DLVPTLLDLLRLEVPADVEGVSHAPALLAPDTENAAVRDHVYTAKTYHDSFDPIRAIR
TKEYSYIENYAPRPLLDLPWDIQESPAGMAVAPLVKAPRPQRELYDLRADPTETNNLL
AGDDSTQGVAAIAADLAVRLHDWRQRTADVIPSDFAGSRIAERYTETYLRIHRKTPTG
RSAIAADRGIDEHCS"
misc_feature complement(390851..392056)
/locus_tag="BCG_0336c"
/note="Arylsulfatase A and related enzymes [Inorganic ion
transport and metabolism]; Region: AslA; COG3119"
/db_xref="CDD:225661"
misc_feature complement(391307..392050)
/locus_tag="BCG_0336c"
/note="Sulfatase; Region: Sulfatase; cl17466"
/db_xref="CDD:248020"
gene 392262..394082
/gene="PE_PGRS5"
/locus_tag="BCG_0337"
/db_xref="GeneID:4697403"
CDS 392262..394082
/gene="PE_PGRS5"
/locus_tag="BCG_0337"
/note="In Mycobacterium bovis BCG Pasteur, and
Mycobacterium bovis, a 45 bp in-frame insertion leads to a
longer product compared to its homolog in Mycobacterium
tuberculosis strain H37Rv (606 aa versus 591 aa)"
/codon_start=1
/transl_table=11
/product="PE-PGRS family protein"
/protein_id="YP_976435.1"
/db_xref="GI:121636212"
/db_xref="GeneID:4697403"
/translation="MSFVIAQPEMIAAAAGELASIRSAINAANAAAAAQTTGVMSAAA
DEVSTAVAALFSSHAQAYQAASAQAAAFHAQVVRTLTVDAGAYASAEAANAGPNMLAA
VNAPAQALLGRPLIGNGANGAPGTGQAGGDGGLLFGNGGNGGSGAPGQAGGAGGAAGF
FGNGGNGGDGGAGANGGAGGTAGWFFGFGGNGGAGGIGVAGINGGLGGAGGDGGNAGF
FGNGGNGGMGGAGAAGVNAVNPGLATPVTPAANGGNGLNLVGVPGTAGGGADGANGSA
IGQAGGAGGDGGNASTSGGIGIAQTGGAGGAGGAGGDGAPGGNGGNGGSVEHTGATGS
SASGGNGATGGNGGVGAPGGAGGNGGHVSGGSVNTAGAGGKGGNGGTGGAGGPGGHGG
SVLSGPVGDSGNGGAGGDGGAGVSATDIAGTGGRGGNGGHGGLWIGNGGDGGAGGVGG
VGGAGAAGAIGGHGGDGGSVNTPIGGSEAGDGGKGGLGGDGGDGAAGGDGGAGGDGGG
RGIFGQFGAGGAGGAGGVGGAGGAGGTGGGGGNGGAIFNAGTPGAAGTGGDGGVGGTG
AAGGKGGAGGSGGVNGATGADGAKGLDGATGGKGNNGNPG"
gene 394225..394452
/locus_tag="BCG_0338"
/db_xref="GeneID:4695718"
CDS 394225..394452
/locus_tag="BCG_0338"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976436.1"
/db_xref="GI:121636213"
/db_xref="GeneID:4695718"
/translation="MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRV
ALRDYTAKTVPALDIDAYAQRVYQANRAAGS"
gene 394449..394751
/locus_tag="BCG_0339"
/db_xref="GeneID:4698968"
CDS 394449..394751
/locus_tag="BCG_0339"
/note="Differs from Mb0307 by 1aa, S13N"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976437.1"
/db_xref="GI:121636214"
/db_xref="GeneID:4698968"
/translation="MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGR
VPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPLGNAGVAALREAASVVTALLC"
gene 394799..395020
/locus_tag="BCG_0340"
/db_xref="GeneID:4698642"
CDS 394799..395020
/locus_tag="BCG_0340"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976438.1"
/db_xref="GI:121636215"
/db_xref="GeneID:4698642"
/translation="MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTAR
VTVTAADLRRLRGAVAGLGDPELMRQAWR"
misc_feature 394823..>394900
/locus_tag="BCG_0340"
/note="hypothetical protein; Region: PHA01748"
/db_xref="CDD:222832"
gene 395017..395442
/locus_tag="BCG_0341"
/db_xref="GeneID:4698422"
CDS 395017..395442
/locus_tag="BCG_0341"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976439.1"
/db_xref="GI:121636216"
/db_xref="GeneID:4698422"
/translation="MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEV
GFSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLI
AATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA"
misc_feature 395035..395415
/locus_tag="BCG_0341"
/note="PIN domain of the Rv0301 toxin of Mycobacterium
tuberculosis and other uncharacterized, annotated PilT
protein domain proteins; Region: PIN_MtRv0301; cd09882"
/db_xref="CDD:189052"
misc_feature order(395041..395043,395143..395145,395311..395313,
395365..395367)
/locus_tag="BCG_0341"
/note="putative active site [active]"
/db_xref="CDD:189052"
gene 395579..396211
/locus_tag="BCG_0342"
/db_xref="GeneID:4695467"
CDS 395579..396211
/locus_tag="BCG_0342"
/note="Differs from Mb0310 by 1aa A124V"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976440.1"
/db_xref="GI:121636217"
/db_xref="GeneID:4695467"
/translation="MGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDIRDAC
GLAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQ
SQHPDFLRLFYLLSMERSQDPAVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLV
VAELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET"
misc_feature 395588..>395947
/locus_tag="BCG_0342"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature 395633..395773
/locus_tag="BCG_0342"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 396208..397116
/locus_tag="BCG_0343"
/db_xref="GeneID:4697256"
CDS 396208..397116
/locus_tag="BCG_0343"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="dehydrogenase/reductase"
/protein_id="YP_976441.1"
/db_xref="GI:121636218"
/db_xref="GeneID:4697256"
/translation="MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRA
AMEELGEPNRCSVLEVDLASVRSVRSFVETVRTTPLPPIRALVCNAGLQVVSGIAFTD
DGVEMTFGVNHLGHFALVTGILDWLARPARIVVVSSGTHDPSKHTGMPDPRYTCAADL
AHPPTDQNTPAEGRRRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLA
RDYPPILRLAYRLLSPMLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIR
SSAESYDRAKALDLWETSERLLAQVT"
misc_feature 396214..397107
/locus_tag="BCG_0343"
/note="light-dependent protochlorophyllide reductase
(LPOR)-like, classical (c)-like SDRs; Region:
LPOR_like_SDR_c_like; cd09810"
/db_xref="CDD:187670"
misc_feature 396226..397098
/locus_tag="BCG_0343"
/note="protochlorophyllide reductase; Region: PLN00015"
/db_xref="CDD:177654"
misc_feature order(396235..396237,396241..396252,396313..396321,
396385..396393,396472..396480,396538..396540,
396631..396639,396736..396738,396748..396750,
396832..396843,396847..396852)
/locus_tag="BCG_0343"
/note="putative NAD(P) binding site [chemical binding];
other site"
/db_xref="CDD:187670"
misc_feature order(396541..396543,396637..396639,396736..396738,
396748..396750)
/locus_tag="BCG_0343"
/note="active site"
/db_xref="CDD:187670"
gene complement(397124..400567)
/gene="PPE5"
/locus_tag="BCG_0344c"
/db_xref="GeneID:4697219"
CDS complement(397124..400567)
/gene="PPE5"
/locus_tag="BCG_0344c"
/note="In Mycobacterium tuberculosis strain H37Rv, PPE5
and PPE6 exist as separate genes. In Mycobacterium bovis
BCG Pasteur, and Mycobacterium bovis, a frameshift due to
a single base deletion (g-*) leads to a shorter CDS
(Mb0312c and BCG_0344c) equivalent to the 3' end of
Rv0304c/PPE5. Differs from Rv0304c by 3aa, S481G, F708S,
A955T, and 5 codon in-frame deletion at position 503"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976442.1"
/db_xref="GI:121636219"
/db_xref="GeneID:4697219"
/translation="MFNSGDGNIGFFNSGTGNFGIGNTGTGNFGIGNSGSTSTGLFNS
GDGNTGGFNPGNFNTGNFNTGSFNTGGFNAGNTNTGHFNTGNYNTGIANTGDVSTGAF
ISGNYSNGILWRGDYQGLIGYSYALTIPEIPAHLDVNIPIDIPITGSFTDLVVDNFTI
PIIGFESFAFSFHIHTEPDIGPIIVPSFVLSVPTFAIAVGGPTTAINISATAGLGPIT
IPIIDIPAAPGIGNSTTSPSSGFFNTGAGTASGFGNVGGNTSGLWNLASAASGVSGLL
NVGALGSGVANVGNTISGIYNTSPLDLGTPAFGSGLANIAGLLQGGAGTTILDLAGLG
NLNVGLANLGGSNFGIGNTGIFNVGFANVGNHNIGLANLGNYSVGFANSGNYHIGIAN
TGSANIGFANTGSGNIGIGLTGTGQIGFGSFNSGSHNIGLFNSGDGNVGFFNSGTGNV
GIGNTGTANFGIANSGSFNTGLGNTGSTNTSLFNPGNVNTGVGNTGSINTGSFNTGST
NTGSFNLGDHNTGSFNSGDYNTGYFNAGDYNTGVANTGNVNTGAFISGNYSNGFFWRG
DYQGLIGLSTTITIPEIPYRYDLSVPIDIPITGTVVATTPNSFTIPGFQIRVLLGPAA
VLVNEMIGPITIDVNQVIAIDSPIQQTISMVGTGGFGPIPIGISIGGTPGFGNSTTGP
SSGFFHTGAGHVSGFGNFGAGNMSGFGNFGAGNSGFFNAGGLGNSGLLNFGALQSGLA
NLGNTISGVYNTSTLDLATPAFGSGIANIGANLAGLFLDNTGNLTLNFGVANQGGLNA
GIGNLGSVNIGFVNTGDSNLGIGNLGDLNFGGVNIGGNNIGIANTGIFDIGLANLGSY
NIGLANLGDDNLGFGNAGSYNIGFANFGSDNLGFANTGSYNIGFANTGNNNIGVGLTG
NGQIGIGSLNSGSNNIGLFNSGSGNIGFFNSGTGNVGIFNAGTGNFGLANSGGFNTGI
GNAGSTNTGVFNPGDLNTGSFNPGSFNTGGFNPGSGNTGYLNTGDYNTGVANTGDVDT
GAFITGSYSNGFLVSGDYQGLIGLPLLGIPVTPGYFNLTGGPSSGFFNSGAGSVSGFV
NSGAGLSGYLNTGALGSGVANVGNTISGWLNASALDLATPGFLSGIGNFGTNLAGFFR
G"
misc_feature complement(397841..397957)
/gene="PPE5"
/locus_tag="BCG_0344c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(397547..397663)
/gene="PPE5"
/locus_tag="BCG_0344c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(397487..397603)
/gene="PPE5"
/locus_tag="BCG_0344c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
gene complement(400711..406638)
/gene="PPE6"
/locus_tag="BCG_0345c"
/db_xref="GeneID:4696876"
CDS complement(400711..406638)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="In Mycobacterium tuberculosis strain H37Rv, PPE5
and PPE6 exist as separate genes. In Mycobacterium bovis
BCG Pasteur, and Mycobacterium bovis, a single base
deletion (t-*) resulting in the absence of a stop codon
leads to a longer product. The second part of this CDS
shares homology with the 5' end of Rv0304c/PPE5. Differs
from Mb0313c by in-frame deletion of 10 codons"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976443.1"
/db_xref="GI:121636220"
/db_xref="GeneID:4696876"
/translation="MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADELAVAASW
FGSVTSGLADAAWRGPAAVAMARAVAPYLGWLISATAQAEQAAAQARVAVATFEAARA
ATVHPAIVAANRAVLVSLVSSNLLGFNAPAIAATEAAYERMWAQDVAAMVGYHAGASA
AVSALMPFTQQLKKLAGLSERLTSAAAAAAGPPSAAGFNLGLANVGANNVGNGNVGVF
NVGFGNLGSYNLGFANLGSDNLGLANLGGHNIGFANTGSNNVGFGNTGSNNVGIGLTG
NGQIGFGSFNSGSHNIGLFNSGSGNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGW
FNTGDVNTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNTGAFIAGNYSN
GVLWRGDYQGLIGADIALEIPAIPINAQLFSMPIHQVMVMPGSVMTIPGMRLPFTSIV
PFVVYYGPVELPQSTLTLPTVTITVGGPTTTIDGNLTGMVGGVSIPLIKIPAAPGFGN
STTSPSSGFFNAGAGTASGFGNFGGGASGFWNLASATSGLSGFGNVGALGSGVANVGN
TISGLYNTSTSNLATPAFNSGLLHHSVGTMTLNFGLANVGGNNVGGANAGIFNVGLAN
LGDYNIGFGNLGGDNLGFAHAGSYNIGFANTGSNNLGFANTGDNNIGFANIGSNNIGI
GLTGSGQIGFGSLNSGSHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTGNWGIGNSGAG
NFGIGNAGSTNTGLFNSGDLNTGSLNPGSYNTGSVNTGSVNTGGFNAGNYNTGYFNTG
DYNTGMANTGNINTGAFISGNHSNGLLWRGDNQGLIDLAIGVDIPEIPIVSVDVNIPI
HIPITASFTDIVYSGLDLPPNTAVTVIFFGPVDIDPFTVPVIRITGPTPVVMVGGPTT
AINIGATVGVDAINIPIIHIPATPGFGNSTGGLSSGFFNSGAGSASGFGNFGGAASGF
MNLVSTTSGMSGFLNVGALGSGVANVGNTISGIYNVGTSDLSTPAVNSGLANIGTNIA
GLLRDGAGTAAINLGLANHGNLNVGFASLGGFNFGGATIGHNNVGIGNTGIFDVGLAN
LGSYNIGFGNLGDDNLGFGNFGSYNIGFGNVGNDNLGFANAGGGNIGFANTGSNNVGF
GNTGSNNVGIGLTGNGQIGFGSFNSGSGNIGLFNSGSNNIGFFNSGSGNFGIANSGSF
NTGIGNTGNTNTGLFNSGDVNTGAFNPGSFNTGSFNTGSFNTGGFNPGNTNTGYLNIG
NYNTGIANTGDVDTGAFITGNYSNGLFLSGDYQGLVGLNLVIDMPLPISLGVNIPIDI
PITASAGNITLMGVTIPPTGDIVLSSIAGQRAHFGPITIPNITVVGPTTTVAIGGPNT
AITITGGGAIRIPLISIPAAPGFGNSTTNPSSGFFNTGAGGASGFGNFGGANSGFWNL
ASATSGASGLLNVGALGSGLANVGTTVSGFYNTSTSDLATPAFNSGLANISTSIAGLL
RDSTGTMVLNLGLANHGTLNVGIANLGDYNIGFANLGSANFGSANIGGNNIGGANTGI
FDIGLANLGSYNIGFGNFGDDNLGFGNLGSYNVGFGNLGNDNLGFANTGSNNIGFANT
GSNNIGIGLTGDGQIGFGSLNSGSGNIGLFNSGSGNIGFFNSGNGNVGIGNTGTANFG
LGNTGSTNTGFFNSGDVNTGIGNTGSFNTGSFNPGDSNTGDFNPGSYNTGLGNTGDVD
TGAFISGSYSNGFLWSGNYQGLIGLHAALAIPEIALTFGVDIPIHIPINIDAGVVTLQ
GFSIVAAENNIDFTPIIIPTINITLPTAAITVGGPTTSIGITASAGIGSITIPIIDIP
ATSGFGNSTTSPSSGFFNSGAGSASGFLNVVAGASGISGYLNVGALGSGVTNVGHTVS
GFYNASALDLVTPAFASGLMRDGMGTMTLNLGLANLGSNNAGFGNTGIFDVGVANLGN
YNIGFGNFGDDNLALPT"
misc_feature complement(406150..406617)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="PPE family; Region: PPE; pfam00823"
/db_xref="CDD:189731"
misc_feature complement(405826..405942)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(405622..405741)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(404596..404712)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(404152..>404673)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:35210"
misc_feature complement(404302..404421)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(404242..404358)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(404182..404298)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(401527..401646)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(401467..401583)
/gene="PPE6"
/locus_tag="BCG_0345c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
gene 406841..407512
/locus_tag="BCG_0346"
/db_xref="GeneID:4698215"
CDS 406841..407512
/locus_tag="BCG_0346"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976444.1"
/db_xref="GI:121636221"
/db_xref="GeneID:4698215"
/translation="MFSAPERRAVYRVIAERRDMRRFVPGGVVSEDVLARLLHAAHAA
PSVGLMQPWRFIRITDETLKRRIHALVDDERLLTAEALGAREEEFLALKVEGILDCAE
LLVVALCDRRGSYIFGRRTLPQMDLASVSCAIQNLWLAARSEGLGMGWVSLFDPQRLA
ALLAMPADAEPVAILCLGPVPEFPDRPALELDGWAYARPLAEFVSENRWSYPSALATD
HHHGE"
misc_feature 406871..407452
/locus_tag="BCG_0346"
/note="Subfamily of the nitroreductase family that
includes BluB protein in Rhodobacter capsulatus is
involved in the conversion of cobinamide to cobalamin in
Cobalamin (vitamin B12) biosynthesis. Nitroreductases
typically reduce their substrates by using NAD(P)...;
Region: BluB; cd02145"
/db_xref="CDD:239059"
misc_feature order(406889..406891,406895..406897,406901..406903,
406982..406984,407294..407299)
/locus_tag="BCG_0346"
/note="putative FMN binding site [chemical binding]; other
site"
/db_xref="CDD:239059"
gene complement(407500..407982)
/locus_tag="BCG_0347c"
/db_xref="GeneID:4695774"
CDS complement(407500..407982)
/locus_tag="BCG_0347c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976445.1"
/db_xref="GI:121636222"
/db_xref="GeneID:4695774"
/translation="MAVIVRKWFGLGRLPADLRCQVEAEGLIYLAEYVAVTRRFTGVI
PGLRASHSIASYVGALAFTEQRVLGTLSMVPKLAGRVVDARWDGPQAGAATAEISPTG
LQLDLDVADVDPKFSGQLALHFKATIGEDVLSRLPRRSLAFDVPAEYVNLAVGVTYSP
"
gene 408040..408756
/locus_tag="BCG_0348"
/db_xref="GeneID:4697716"
CDS 408040..408756
/locus_tag="BCG_0348"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976446.1"
/db_xref="GI:121636223"
/db_xref="GeneID:4697716"
/translation="MTRPQALLAVSLAFVATAVYAVMWVGHSQDWGWLHSFDWSLLNA
AHDIGIKNPAWVRFWDGVSLILGPVVLRPLGLLAAMVALAKRKIRIALLLLACLPLNA
IMTIAAKSVAHRPRPATALVSAHSTSFPSGHALEATASVLALLTVLLPMLHSRFTRHI
AITVGALCVLTVGVARVALNVHHPTDVVAGWALGYLYFLVCLCVFRPPSIFGAQRASH
ALSPPVEVSRQPEPEVDTAR"
misc_feature 408130..408657
/locus_tag="BCG_0348"
/note="PAP2_like_2 proteins. PAP2 is a super-family of
phosphatases and haloperoxidases. This subgroup, which is
specific to bacteria, lacks functional characterization
and may act as a membrane-associated lipid phosphatase;
Region: PAP2_like_2; cd03392"
/db_xref="CDD:239486"
misc_feature <408331..408672
/locus_tag="BCG_0348"
/note="Membrane-associated phospholipid phosphatase [Lipid
metabolism]; Region: PgpB; COG0671"
/db_xref="CDD:223743"
misc_feature order(408364..408366,408385..408387,408430..408438,
408565..408567,408583..408585,408595..408597)
/locus_tag="BCG_0348"
/note="active site"
/db_xref="CDD:239486"
gene 408858..409514
/locus_tag="BCG_0349"
/db_xref="GeneID:4698232"
CDS 408858..409514
/locus_tag="BCG_0349"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976447.1"
/db_xref="GI:121636224"
/db_xref="GeneID:4698232"
/translation="MSRLLALLCAAVCTGCVAVVLAPVSLAVVNPWFANSVGNATQVV
SVVGTGGSTAKMDVYQRTAAGWQPLKTGITTHIGSAGMAPEAKSGYPATPMGVYSLDS
AFGTAPNPGGGLPYTQVGPNHWWSGDDNSPTFNSMQVCQKSQCPFSTADSENLQIPQY
KHSVVMGVNKAKVPGKGSAFFFHTTDGGPTAGCVAIDDATLVQIIRWLRPGAVIAIAK
"
misc_feature 408945..409511
/locus_tag="BCG_0349"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG3786"
/db_xref="CDD:226309"
gene complement(409584..410075)
/locus_tag="BCG_0350c"
/db_xref="GeneID:4695402"
CDS complement(409584..410075)
/locus_tag="BCG_0350c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976448.1"
/db_xref="GI:121636225"
/db_xref="GeneID:4695402"
/translation="MCCNGVVTPGDPADIAAIKQLKYRYLRALDTKHWDDFTDTLAED
VTGDYGSSVGTELHFTNRADLVDYLRQALGPGVITEHRVTHPEITVTGDTATGIWYLQ
DRVIVAEFNFMLIGAAFYHDQYRRTTDGWRISATGYDRTYEATMSLAGLNFNIRPGRA
LAD"
misc_feature complement(409674..410039)
/locus_tag="BCG_0350c"
/note="SnoaL-like domain; Region: SnoaL_4; pfam13577"
/db_xref="CDD:222235"
misc_feature complement(409674..410024)
/locus_tag="BCG_0350c"
/note="SnoaL-like domain; Region: SnoaL_3; pfam13474"
/db_xref="CDD:222158"
gene 410099..411328
/locus_tag="BCG_0351"
/db_xref="GeneID:4698435"
CDS 410099..411328
/locus_tag="BCG_0351"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976449.1"
/db_xref="GI:121636226"
/db_xref="GeneID:4698435"
/translation="MSQSRYAGLSRSELAVLLPELLLIGQLIDRSGMAWCIQAFGRQE
MLQIAIEEWAGASPIYTKRMQKALNFEGDDVPTIFKGLQLDIGAPPQFMDFRFTLHDR
WHGEFHLDHCGALLDVEPMGDDYVVGMCHTIEDPTFDATAIATNPRAQVRPIHRPPRK
PADRHPHCAWTVIIDESYPEAEGIPALDAVRETKAATWELDNVDASDDGLVDYSGPLV
SDLDFGAFSHSALVRMADEVCLQMHLLNLSFAIAVRKRAKADAQLAISVNTRQLIGVA
GLGAERIHRAMALPGGIEGALGVLELHPLLNPAGYVLAETSPDRLVVHNSPAHADGAW
ISLCTPASVQPLQAIATAVDPHLKVRISGTDTDWTAELIEADAPASELPEVLVAKVSR
GSVFQFEPRRSLPLTVK"
gene 411483..413345
/locus_tag="BCG_0352"
/db_xref="GeneID:4698919"
CDS 411483..413345
/locus_tag="BCG_0352"
/note="Differs from Rv0312 by 2aa, G159S, L563P"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976450.1"
/db_xref="GI:121636227"
/db_xref="GeneID:4698919"
/translation="MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPS
QNPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSE
IAIAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGGV
VGLLDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGY
GDDVDPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDL
IQDPLTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQ
PGCAAAMGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDR
ELAWSQTDFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSA
VVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAP
LPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTELPVT
TTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG"
misc_feature 411492..>412853
/locus_tag="BCG_0352"
/note="Molecular chaperone [Posttranslational
modification, protein turnover, chaperones]; Region: DnaK;
COG0443"
/db_xref="CDD:223520"
misc_feature <411786..412487
/locus_tag="BCG_0352"
/note="Nucleotide-Binding Domain of the sugar
kinase/HSP70/actin superfamily; Region:
NBD_sugar-kinase_HSP70_actin; cl17037"
/db_xref="CDD:247684"
misc_feature order(411903..411905,411975..411986,412407..412409)
/locus_tag="BCG_0352"
/note="nucleotide binding site [chemical binding]; other
site"
/db_xref="CDD:212657"
gene 413417..413803
/locus_tag="BCG_0353"
/db_xref="GeneID:4697371"
CDS 413417..413803
/locus_tag="BCG_0353"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976451.1"
/db_xref="GI:121636228"
/db_xref="GeneID:4697371"
/translation="MGDYGPFGFDPDEFDRVIREGSEGLRDAFERIGRFLSSSGAGTG
WSAIFEDLSRRSRPAPETAGEAGDGVWAIYTVDADGGARVEQVYATELDALRANKDNT
DPKRKVRFLPYGIAVSVLDDPVDEAQ"
misc_feature <413453..>413797
/locus_tag="BCG_0353"
/note="Molecular chaperone, HSP90 family
[Posttranslational modification, protein turnover,
chaperones]; Region: HtpG; COG0326"
/db_xref="CDD:223403"
gene complement(413806..414468)
/locus_tag="BCG_0354c"
/db_xref="GeneID:4697400"
CDS complement(413806..414468)
/locus_tag="BCG_0354c"
/note="Differs from Rv0314c by 1aa, A184V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976452.1"
/db_xref="GI:121636229"
/db_xref="GeneID:4697400"
/translation="MIVVWEHLCMNPEDDPEARIRELERPLADVARASELGGSQSGGY
TYPPGPPPPPYSYGGPFGGPSPRSSSGNRAWWILAAVVVVGVLVLVGGIAAFSAQRLS
QGNFVVLSPTPSVSRAVPTPTAQPATTLPPAGASLSVSGVNVNRTIACNDSIVSVSGM
SNTVVITGHCTSLTVSGMRNSVTADSVDTIEAAGFNNEVTYHSGSPKISNAGGSNSVQ
QG"
misc_feature complement(413821..414003)
/locus_tag="BCG_0354c"
/note="Protein of unknown function (DUF3060); Region:
DUF3060; pfam11259"
/db_xref="CDD:204617"
gene 414529..415413
/locus_tag="BCG_0355"
/db_xref="GeneID:4697754"
CDS 414529..415413
/locus_tag="BCG_0355"
/EC_number="3.2.1.-"
/note="Differs from Rv0315 by 1aa, T260K"
/codon_start=1
/transl_table=11
/product="beta-1,3-glucanase"
/protein_id="YP_976453.1"
/db_xref="GI:121636230"
/db_xref="GeneID:4697754"
/translation="MLMPEMDRRRMMMMAGFGALAAALPAPTAWADPSRPAAPAGPTP
APAAPAAATGGLLFHDEFDGPAGSVPDPSKWQVSNHRTPIKNPVGFDRPQFFGQYRDS
RQNVFLDGNSNLVLRATREGNRYFGGLVHGLWRGGIGTTWEARIKFNCLAPGMWPAWW
LSNDDPGRSGEIDLIEWYGNGTWPSGTTVHANPDGTAFETCPIGVDGGWHNWRVTWNP
SGMYFWLDYADGIEPYFSVPATGIEDLNEPIREWPFNDPGYTVFPVLNLAVGGSGGGD
PATGSYPQEMLVDWVRVF"
misc_feature 414694..415410
/locus_tag="BCG_0355"
/note="Beta-glucanase/Beta-glucan synthetase [Carbohydrate
transport and metabolism]; Region: SKN1; COG2273"
/db_xref="CDD:225182"
misc_feature 414700..415410
/locus_tag="BCG_0355"
/note="Laminarinase, member of the glycosyl hydrolase
family 16; Region: GH16_laminarinase_like; cd08023"
/db_xref="CDD:185693"
misc_feature order(414937..414939,414994..414996,415006..415008,
415039..415041,415045..415047,415054..415056,
415096..415098)
/locus_tag="BCG_0355"
/note="active site"
/db_xref="CDD:185693"
misc_feature order(415039..415041,415045..415047,415054..415056)
/locus_tag="BCG_0355"
/note="catalytic residues [active]"
/db_xref="CDD:185693"
gene 415462..416076
/locus_tag="BCG_0356"
/db_xref="GeneID:4695701"
CDS 415462..416076
/locus_tag="BCG_0356"
/EC_number="5.3.3.-"
/codon_start=1
/transl_table=11
/product="muconolactone isomerase"
/protein_id="YP_976454.1"
/db_xref="GI:121636231"
/db_xref="GeneID:4695701"
/translation="MEFLVTMTTRVPDSMPADAVERVRAREAARSRELAAQGKLLRLW
RPPLRPGEWRTLGLFAADDNGELEQLLASMPPRSWRTDDVTPLGAHPNDPVGQGITIA
PGKGPEFLIATTIMVPPGTPAQVVDDTVAREARRAPELAGRGHLVRLWALPDGPDGQR
TLGLWRARDPGELMAILESLPLAGWMTIETTPLSPHPDDPIRMP"
misc_feature 415462..415776
/locus_tag="BCG_0356"
/note="Muconolactone delta-isomerase [Secondary
metabolites biosynthesis, transport, and catabolism];
Region: CatC1; COG4829"
/db_xref="CDD:227166"
misc_feature 415783..416064
/locus_tag="BCG_0356"
/note="Muconolactone delta-isomerase; Region: MIase;
cl01992"
/db_xref="CDD:242825"
gene complement(416100..416870)
/gene="glpQ2"
/locus_tag="BCG_0357c"
/db_xref="GeneID:4698721"
CDS complement(416100..416870)
/gene="glpQ2"
/locus_tag="BCG_0357c"
/EC_number="3.1.4.46"
/codon_start=1
/transl_table=11
/product="glycerophosphoryl diester phosphodiesterase
glpQ2"
/protein_id="YP_976455.1"
/db_xref="GI:121636232"
/db_xref="GeneID:4698721"
/translation="MEFLRHGGRIAMAHRGFTSFRLPMNSMGAFQEAAKLGFRYIETD
VRATRDGVAVILHDRRLAPGVGLSGAVDRLDWRDVRKAQLGAGQSIPTLEDLLTALPD
MRVNIDIKAASAIEPTVNVIERCNAHNRVLIGSFSERRRRRALRLLTKRVASSAGTGA
LLAWLTARPLGSRAYAWRMMRDIDCVQLPSRLGGVPVITPARVRGFHAAGRQVHAWTV
DEPDVMHTLLDMDVDGIITDRADLLRDVLIARGEWDGA"
misc_feature complement(416130..416840)
/gene="glpQ2"
/locus_tag="BCG_0357c"
/note="Glycerophosphodiester phosphodiesterase domain of
Streptomyces coelicolor cytoplasmic phosphodiesterases
UgpQ2 and similar proteins; Region:
GDPD_cytoplasmic_ScUgpQ2_like; cd08561"
/db_xref="CDD:176504"
misc_feature complement(416145..416831)
/gene="glpQ2"
/locus_tag="BCG_0357c"
/note="Glycerophosphoryl diester phosphodiesterase family;
Region: GDPD; pfam03009"
/db_xref="CDD:217317"
misc_feature complement(order(416223..416225,416469..416471,
416547..416549,416700..416702,416739..416741,
416745..416747,416829..416831))
/gene="glpQ2"
/locus_tag="BCG_0357c"
/note="putative active site [active]"
/db_xref="CDD:176504"
misc_feature complement(order(416700..416702,416829..416831))
/gene="glpQ2"
/locus_tag="BCG_0357c"
/note="catalytic site [active]"
/db_xref="CDD:176504"
misc_feature complement(order(416547..416549,416739..416741,
416745..416747))
/gene="glpQ2"
/locus_tag="BCG_0357c"
/note="putative metal binding site [ion binding]; other
site"
/db_xref="CDD:176504"
gene complement(417131..417201)
/gene="tRNA-Gly"
/locus_tag="BCG_t02"
/db_xref="GeneID:4696568"
tRNA complement(417131..417201)
/gene="tRNA-Gly"
/locus_tag="BCG_t02"
/product="tRNA-Gly"
/note="glyU, len: 71 nt. Equivalent to glyU, len: 71 nt,
from Mycobacterium tuberculosis strain H37Rv, (100.0%
identity in 71 nt overlap). tRNA-Gly, anticodon ccc"
/anticodon=(pos:complement(417167..417169),aa:Gly,seq:ccc)
/codon_recognized="GGG"
/db_xref="GeneID:4696568"
gene complement(417232..418026)
/locus_tag="BCG_0358c"
/db_xref="GeneID:4696329"
CDS complement(417232..418026)
/locus_tag="BCG_0358c"
/note="Differs from Rv0318c by 1aa, A223G"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976456.1"
/db_xref="GI:121636233"
/db_xref="GeneID:4696329"
/translation="MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILG
GVVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLV
ALRRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALT
VEVLFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVL
AFAAAALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME"
misc_feature complement(<417457..418011)
/locus_tag="BCG_0358c"
/note="Predicted divalent heavy-metal cations transporter
[Inorganic ion transport and metabolism]; Region: COG0428"
/db_xref="CDD:223505"
gene 418075..418743
/gene="pcp"
/locus_tag="BCG_0359"
/db_xref="GeneID:4696347"
CDS 418075..418743
/gene="pcp"
/locus_tag="BCG_0359"
/EC_number="3.4.19.3"
/note="catalyzes the removal of 5-oxoproline from various
penultimate amino acid residues except L-proline"
/codon_start=1
/transl_table=11
/product="pyrrolidone-carboxylate peptidase"
/protein_id="YP_976457.1"
/db_xref="GI:121636234"
/db_xref="GeneID:4696347"
/translation="MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPN
TFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVL
VGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQK
GLPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPS
RLQI"
misc_feature 418081..418674
/gene="pcp"
/locus_tag="BCG_0359"
/note="Pyroglutamyl peptidase (PGP) type I, also known as
pyrrolidone carboxyl peptidase (pcp) type I: Enzymes
responsible for cleaving pyroglutamate (pGlu) from the
N-terminal end of specialized proteins. The N-terminal
pGlu protects these proteins from...; Region:
Peptidase_C15; cd00501"
/db_xref="CDD:238279"
misc_feature order(418099..418101,418108..418110,418204..418206,
418504..418512)
/gene="pcp"
/locus_tag="BCG_0359"
/note="putative substrate binding pocket [chemical
binding]; other site"
/db_xref="CDD:238279"
misc_feature order(418294..418302,418459..418461,418468..418482,
418597..418602,418606..418608,418633..418638,
418642..418644)
/gene="pcp"
/locus_tag="BCG_0359"
/note="AC domain interface; other site"
/db_xref="CDD:238279"
misc_feature order(418312..418314,418510..418512,418582..418584)
/gene="pcp"
/locus_tag="BCG_0359"
/note="catalytic triad [active]"
/db_xref="CDD:238279"
misc_feature order(418315..418320,418330..418332,418336..418338,
418342..418344,418381..418386,418411..418422,
418438..418440,418489..418494,418501..418503)
/gene="pcp"
/locus_tag="BCG_0359"
/note="AB domain interface; other site"
/db_xref="CDD:238279"
misc_feature 418642..418644
/gene="pcp"
/locus_tag="BCG_0359"
/note="interchain disulfide; other site"
/db_xref="CDD:238279"
gene 418815..419477
/locus_tag="BCG_0360"
/db_xref="GeneID:4698420"
CDS 418815..419477
/locus_tag="BCG_0360"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976458.1"
/db_xref="GI:121636235"
/db_xref="GeneID:4698420"
/translation="MGRHELARDRRKSSAVLAAVLAPAAVFFATGGDVSTLAARADAN
PVLGDDAPCCVQIVPVAPLAFSSQISGGEIGTGLAASQFASASRWRIVSRYLPVGVAP
EQGLQVKTVLTARSISAAFPEIREIGGVRPDALRWHPNGLALDVMVPNPGTAEGIALG
NEIVAFVLKNATRFGMQDVIWRGAYYTPNGARTTGAGHYDHIHITTVGGGYPTGEELY
IR"
gene 419509..420081
/gene="dcd"
/locus_tag="BCG_0361"
/db_xref="GeneID:4697227"
CDS 419509..420081
/gene="dcd"
/locus_tag="BCG_0361"
/EC_number="3.5.4.13"
/note="Catalyzes the formation of dUTP from dCTP in
thymidylate biosynthesis"
/codon_start=1
/transl_table=11
/product="deoxycytidine triphosphate deaminase"
/protein_id="YP_976459.1"
/db_xref="GI:121636236"
/db_xref="GeneID:4697227"
/translation="MLLSDRDLRAEISSGRLGIDPFDDTLVQPSSIDVRLDCLFRVFN
NTRYTHIDPAKQQDELTSLVQPVDGEPFVLHPGEFVLGSTLELFTLPDNLAGRLEGKS
SLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCMLRLTSPSEH
PYGSSRAGSKYQGQRGPTPSRSCQNFIRST"
misc_feature 419710..419955
/gene="dcd"
/locus_tag="BCG_0361"
/note="Trimeric dUTP diphosphatases; Region:
trimeric_dUTPase; cd07557"
/db_xref="CDD:143638"
misc_feature order(419725..419727,419740..419745,419749..419751,
419797..419799,419803..419820,419833..419841,
419857..419859,419866..419868,419887..419889,
419893..419895,419899..419901,419905..419907,
419917..419931,419938..419940,419950..419952)
/gene="dcd"
/locus_tag="BCG_0361"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:143638"
misc_feature order(419809..419817,419857..419865,419872..419874,
419884..419889)
/gene="dcd"
/locus_tag="BCG_0361"
/note="active site"
/db_xref="CDD:143638"
gene 420187..421518
/gene="udgA"
/locus_tag="BCG_0362"
/db_xref="GeneID:4697262"
CDS 420187..421518
/gene="udgA"
/locus_tag="BCG_0362"
/EC_number="1.1.1.22"
/codon_start=1
/transl_table=11
/product="udp-glucose 6-dehydrogenase udgA"
/protein_id="YP_976460.1"
/db_xref="GI:121636237"
/db_xref="GeneID:4697262"
/translation="MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDI
PFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHA
VIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAV
HDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLA
TKISFINAISEVCEAAGADVSQLADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMA
RAGELGADQALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDD
VRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLT
EWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH"
misc_feature 420187..421458
/gene="udgA"
/locus_tag="BCG_0362"
/note="Predicted UDP-glucose 6-dehydrogenase [Cell
envelope biogenesis, outer membrane]; Region: Ugd;
COG1004"
/db_xref="CDD:223936"
misc_feature 420199..>420423
/gene="udgA"
/locus_tag="BCG_0362"
/note="3-hydroxyacyl-CoA dehydrogenase, NAD binding
domain; Region: 3HCDH_N; pfam02737"
/db_xref="CDD:202367"
misc_feature 420793..421086
/gene="udgA"
/locus_tag="BCG_0362"
/note="UDP-glucose/GDP-mannose dehydrogenase family,
central domain; Region: UDPG_MGDP_dh; pfam00984"
/db_xref="CDD:201536"
misc_feature 421150..421452
/gene="udgA"
/locus_tag="BCG_0362"
/note="UDP binding domain; Region: UDPG_MGDP_dh_C;
smart00984"
/db_xref="CDD:214954"
gene complement(421507..422178)
/locus_tag="BCG_0363c"
/db_xref="GeneID:4696865"
CDS complement(421507..422178)
/locus_tag="BCG_0363c"
/note="Differs from Rv0323c by 1aa, G142S"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976461.1"
/db_xref="GI:121636238"
/db_xref="GeneID:4696865"
/translation="MNSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGL
CFTHGEASTLGRTDRNLGEVRREELAAAAQVLGVDHVQLLAYPDNGLAQIPLNELTQR
VVDALAGADLLLVFDDNGVTGHPDHRRATEAALAAASTPGIPVLAWALPQPIADRLNA
EFSASFGGRGHGHLDIMIEVDRSRQLAAIGCHFTQSADNPVLWRRLELLGDREYLRWL
RRSVP"
misc_feature complement(421519..422178)
/locus_tag="BCG_0363c"
/note="Uncharacterized proteins, LmbE homologs [Function
unknown]; Region: COG2120"
/db_xref="CDD:225031"
gene 422279..422959
/locus_tag="BCG_0364"
/db_xref="GeneID:4696364"
CDS 422279..422959
/locus_tag="BCG_0364"
/note="Differs from Rv0324 by 1aa, A168T"
/codon_start=1
/transl_table=11
/product="ArsR family transcriptional regulator"
/protein_id="YP_976462.1"
/db_xref="GI:121636239"
/db_xref="GeneID:4696364"
/translation="MAGQSDRKAALLDQVARVGKALANGRRLQILDLLAQGERAVEAI
ATATGMNLTTASANLQALKSGGLVEARREGTRQYYRIAGEDVARLFALVQVVADEHLA
DVAVAAADVLGSPEDAITRAELLRRREAGEVTLVDVRPHEEYQAGHIPGAINIPIAEL
ADRLAELAGDRDIVAYCRGAYCVMAPDAVRIARDAGREVKRLDDGMLEWRLAGLPVDE
GAPVGHGD"
misc_feature 422333..422542
/locus_tag="BCG_0364"
/note="Arsenical Resistance Operon Repressor and similar
prokaryotic, metal regulated homodimeric repressors. ARSR
subfamily of helix-turn-helix bacterial transcription
regulatory proteins (winged helix topology). Includes
several proteins that appear to...; Region: HTH_ARSR;
cd00090"
/db_xref="CDD:238042"
misc_feature order(422333..422338,422342..422344,422351..422353,
422360..422365,422372..422377,422384..422386,
422474..422476,422534..422539)
/locus_tag="BCG_0364"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:238042"
misc_feature order(422336..422341,422351..422359,422396..422404,
422429..422440,422444..422449,422456..422461,
422465..422470,422486..422494,422507..422515)
/locus_tag="BCG_0364"
/note="putative DNA binding site [nucleotide binding];
other site"
/db_xref="CDD:238042"
misc_feature order(422396..422398,422405..422407,422534..422536)
/locus_tag="BCG_0364"
/note="putative Zn2+ binding site [ion binding]; other
site"
/db_xref="CDD:238042"
misc_feature 422669..422908
/locus_tag="BCG_0364"
/note="Rhodanese Homology Domain (RHOD); an alpha beta
fold domain found duplicated in the rhodanese protein. The
cysteine containing enzymatically active version of the
domain is also found in the Cdc25 class of protein
phosphatases and a variety of proteins...; Region: RHOD;
cd00158"
/db_xref="CDD:238089"
misc_feature 422807..422809
/locus_tag="BCG_0364"
/note="active site residue [active]"
/db_xref="CDD:238089"
gene 422966..423655
/locus_tag="BCG_0365"
/db_xref="GeneID:4695771"
CDS 422966..423655
/locus_tag="BCG_0365"
/note="In Mycobacterium tuberculosis strain H37Rv, Rv0325
and Rv0326 exist as 2 genes. In Mycobacterium bovis BCG
Pasteur, and Mycobacterium bovis, the absence of a stop
codon between Rv0325 and Rv0326 due to a single base
transition (t-c) leads to single product"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976463.1"
/db_xref="GI:121636240"
/db_xref="GeneID:4695771"
/translation="MGPKGSLRLVKRQPELLVAQHEHWQDTYRAHPVLYGTRPSEPGV
YAAEVFNADGVQRVLELAAGHGRDTLYFAGQGFTVVATDFSDVAVAQLRRSAQARGVS
ARVQPIVHDLRQPLPVKTGSIDGAFAHMALCMALSTSEIHAVVAEVGRVLRPGGKFIY
TVRHTGDAHYGAGQAHGDDIFECAGFAVHFFRRELVARLATGWVLEEVHDFEEGELPR
RLWRVTVTKPA"
misc_feature 423134..423457
/locus_tag="BCG_0365"
/note="S-adenosylmethionine-dependent methyltransferases
(SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
that use S-adenosyl-L-methionine (SAM or AdoMet) as a
substrate for methyltransfer, creating the product
S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
cd02440"
/db_xref="CDD:100107"
misc_feature order(423146..423166,423212..423217,423293..423301,
423350..423352)
/locus_tag="BCG_0365"
/note="S-adenosylmethionine binding site [chemical
binding]; other site"
/db_xref="CDD:100107"
gene complement(423623..424972)
/gene="cyp135A1"
/locus_tag="BCG_0366c"
/db_xref="GeneID:4698342"
CDS complement(423623..424972)
/gene="cyp135A1"
/locus_tag="BCG_0366c"
/EC_number="1.14.-.-"
/note="Differs from Rv0327c by 1aa, Y100H"
/codon_start=1
/transl_table=11
/product="cytochrome P450 135A1 cyp135A1"
/protein_id="YP_976464.1"
/db_xref="GI:121636241"
/db_xref="GeneID:4698342"
/translation="MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFS
LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEYAR
MRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFG
VTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIA
SRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLW
ELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPA
GTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTE
GAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP"
misc_feature complement(423659..424906)
/gene="cyp135A1"
/locus_tag="BCG_0366c"
/note="Cytochrome P450 [Secondary metabolites
biosynthesis, transport, and catabolism]; Region: CypX;
COG2124"
/db_xref="CDD:32307"
gene 425038..425640
/locus_tag="BCG_0367"
/db_xref="GeneID:4697064"
CDS 425038..425640
/locus_tag="BCG_0367"
/codon_start=1
/transl_table=11
/product="TetR family transcriptional regulator"
/protein_id="YP_976465.1"
/db_xref="GI:121636242"
/db_xref="GeneID:4697064"
/translation="MQQQRTNRDKLLDGALACLRERGYGNTSSRDIARAAGVNIASIN
YHFGSKDALLDDALGRCFSTWNQRVQEAFDHSRAAGPAGQILAVLEATVDSFEQIRPA
VYACVESYAPALRSEALRERLAAGYADVRQHSVDLAGAALAGTDIAPPENLSTIVSVL
MAVIDGLMIQWIADPSATPRSTEVIRALASIGAVVTSQLR"
misc_feature 425059..425634
/locus_tag="BCG_0367"
/note="transcriptional repressor BetI; Region:
betaine_BetI; TIGR03384"
/db_xref="CDD:132427"
misc_feature 425068..425202
/locus_tag="BCG_0367"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
misc_feature 425266..425604
/locus_tag="BCG_0367"
/note="Bacterial transcriptional repressor; Region:
TetR_C_6; pfam13977"
/db_xref="CDD:222485"
gene complement(425621..426247)
/locus_tag="BCG_0368c"
/db_xref="GeneID:4696759"
CDS complement(425621..426247)
/locus_tag="BCG_0368c"
/note="Differs from Rv0329c by 1aa, S129W"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976466.1"
/db_xref="GI:121636243"
/db_xref="GeneID:4696759"
/translation="MRLTHPARRYLSSQAARPTGAFGRLLGRIWRAETADVNRIAVEL
LAPGPGERVCEIGFGPGRTLGLLAAAGAQVSGVEVSTTMIAIAAHHNAKAIAAGLISL
YHGDGVTLPVADHSLDKVLGVHNFYFSPDPRASLCDIARALRPGGRLVLTSISDDQPL
AARFDPAIYRVPPTLDTAAWLGAAGFIDVGIKRSADHPATVWFTATAT"
misc_feature complement(425681..426163)
/locus_tag="BCG_0368c"
/note="Methyltransferase domain; Region: Methyltransf_23;
pfam13489"
/db_xref="CDD:205667"
misc_feature complement(425792..426094)
/locus_tag="BCG_0368c"
/note="S-adenosylmethionine-dependent methyltransferases
(SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
that use S-adenosyl-L-methionine (SAM or AdoMet) as a
substrate for methyltransfer, creating the product
S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
cd02440"
/db_xref="CDD:100107"
misc_feature complement(order(425879..425881,425927..425935,
426011..426016,426062..426082))
/locus_tag="BCG_0368c"
/note="S-adenosylmethionine binding site [chemical
binding]; other site"
/db_xref="CDD:100107"
gene complement(426274..427014)
/locus_tag="BCG_0369c"
/db_xref="GeneID:4697221"
CDS complement(426274..427014)
/locus_tag="BCG_0369c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976467.1"
/db_xref="GI:121636244"
/db_xref="GeneID:4697221"
/translation="MARSIPADRFSAIVAASARVFIAHGYQRTQVQDVADALALAKGT
LYGYAQGKAALFAAAVRYGDAQEALPLASELPVAAPVAGEIAAVVSARLAGEVTDMRL
THALRATLPPGATTGDARAELAGIVTDLYSRLARHRIALKLVDRCAPELPDLAEVWFG
TGRNAQVDAVQAYLVHRERAGLLILPGPAPMVARTIVELCALWAVHLHFDPSPEPWSI
VQPGVIDDDAIAATLAEFVVRATTASSD"
misc_feature complement(<426550..426981)
/locus_tag="BCG_0369c"
/note="Transcriptional regulator [Transcription]; Region:
AcrR; COG1309"
/db_xref="CDD:224228"
misc_feature complement(426838..426978)
/locus_tag="BCG_0369c"
/note="Bacterial regulatory proteins, tetR family; Region:
TetR_N; pfam00440"
/db_xref="CDD:201228"
gene 427128..428294
/locus_tag="BCG_0370"
/db_xref="GeneID:4698412"
CDS 427128..428294
/locus_tag="BCG_0370"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="dehydrogenase/reductase"
/protein_id="YP_976468.1"
/db_xref="GI:121636245"
/db_xref="GeneID:4698412"
/translation="MSKTVLILGAGVGGLTTADTLRQLLPPEDRIILVDRSFDGTLGL
SLLWVLRGWRRPDDVRVRPTAASLPGVEMVTATVAHIDIAAQVVHTDNSVIGYDALVI
ALGAALNTDAVPGLSDALDADVAGQFYTLDGAAELRAKVEALEHGRIAVAIAGVPFKC
PAAPFEAAFLIAAQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSMLKDHGVGF
HPRKALARVDEAARTMHFGDGTSEPFDLLAVVPPHVPSAAARSAGLSESGWIPVDPRT
LSTSADNVWAIGDATVLTLPNGKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTG
TGACYVETGDHQAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT"
misc_feature 427140..428000
/locus_tag="BCG_0370"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox_2; pfam07992"
/db_xref="CDD:203833"
gene 428369..429154
/locus_tag="BCG_0371"
/db_xref="GeneID:4696350"
CDS 428369..429154
/locus_tag="BCG_0371"
/note="Differs from Rv0332 by 1aa, G198E"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976469.1"
/db_xref="GI:121636246"
/db_xref="GeneID:4696350"
/translation="MRKPASSLAKVDYSSAYLEQTHAFGELIRNVDQSTPVPTCPGWS
LGQLFRHVGRGDRWAAQIVRDRLDHFLDPRSVEGGKPPPDPDDAISWLYGGARLLVDA
VEQTGVETPVWTFLGPRPAGWWVRRRLHEVAVHRADVAITVGGEFTLEPNVAADGISE
FLERIAVQAGSGGTPLPLEDDDTLHLHATDPGLLEAGGWTVRRDERGVTWSHRHGKGA
VALRGGATELLLAMVRRLSVADTGIELLGDAGVWQKWLDRTPL"
misc_feature 428414..429073
/locus_tag="BCG_0371"
/note="uncharacterized Actinobacterial protein TIGR03083;
Region: TIGR03083"
/db_xref="CDD:211787"
misc_feature 428414..428788
/locus_tag="BCG_0371"
/note="Mycothiol maleylpyruvate isomerase N-terminal
domain; Region: MDMPI_N; pfam11716"
/db_xref="CDD:204720"
gene 429181..429555
/locus_tag="BCG_0372"
/db_xref="GeneID:4697767"
CDS 429181..429555
/locus_tag="BCG_0372"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976470.1"
/db_xref="GI:121636247"
/db_xref="GeneID:4697767"
/translation="MTTSEIATVLAWHDALNAADIETLVALSTDDIDIGDAHGAVQGH
DALRGWASSLTTTAELGRMYVHHGVVVVEQKITSGEDPGIARTGAAAFRVVQDHVASV
FRHEDLASALAATELTEDDLVD"
misc_feature 429205..>429390
/locus_tag="BCG_0372"
/note="SnoaL-like domain; Region: SnoaL_2; pfam12680"
/db_xref="CDD:221707"
gene 429585..430451
/gene="rmlA"
/locus_tag="BCG_0373"
/db_xref="GeneID:4696702"
CDS 429585..430451
/gene="rmlA"
/locus_tag="BCG_0373"
/EC_number="2.7.7.24"
/codon_start=1
/transl_table=11
/product="glucose-1-phosphate thymidylyltransferase rmlA"
/protein_id="YP_976471.1"
/db_xref="GI:121636248"
/db_xref="GeneID:4696702"
/translation="MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMA
GIRDIQLITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSV
ALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKP
VTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGT
AWLDTGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSG
YGNYLLELLERN"
misc_feature 429585..430301
/gene="rmlA"
/locus_tag="BCG_0373"
/note="G1P_TT_short is the short form of
glucose-1-phosphate thymidylyltransferase; Region:
G1P_TT_short; cd02538"
/db_xref="CDD:133019"
misc_feature 429588..430442
/gene="rmlA"
/locus_tag="BCG_0373"
/note="glucose-1-phosphate thymidylyltransferase, short
form; Region: rmlA; TIGR01207"
/db_xref="CDD:130274"
misc_feature order(429600..429602,429606..429611,429822..429824,
429831..429842,429906..429908,430011..430013,
430056..430061,430089..430091,430173..430175)
/gene="rmlA"
/locus_tag="BCG_0373"
/note="substrate binding site; other site"
/db_xref="CDD:133019"
misc_feature order(429618..429620,429627..429635,429642..429647,
429657..429665,429669..429680,429687..429689,
429762..429764,429918..429923,429984..429995,
430005..430010,430242..430250,430260..430265,
430272..430274,430281..430289,430296..430301)
/gene="rmlA"
/locus_tag="BCG_0373"
/note="tetramer interface; other site"
/db_xref="CDD:133019"
gene complement(430462..430977)
/gene="PE6"
/locus_tag="BCG_0374c"
/db_xref="GeneID:4695583"
CDS complement(430462..430977)
/gene="PE6"
/locus_tag="BCG_0374c"
/note="Differs from Rv0335c and Mb0340 by 1aa P131T"
/codon_start=1
/transl_table=11
/product="PE family protein"
/protein_id="YP_976472.1"
/db_xref="GI:121636249"
/db_xref="GeneID:4695583"
/translation="MRSMGFLHRACRAPSSLPAPLMARPGRSVLARPAATPPGPLCAT
TRPRPPQGNQPPASRISNFPPKRHKTRVLAAAEDEVSAAVAALISAHGRRHHSLNNQA
AAFHGQFAQNLNVGAGSCASAETTADAPPQALLGPADRQRRQRRAVRQWLVRWAAHPG
RATRGFHNHRQ"
misc_feature complement(430597..>430719)
/gene="PE6"
/locus_tag="BCG_0374c"
/note="PE family; Region: PE; pfam00934"
/db_xref="CDD:201515"
gene 431119..432630
/locus_tag="BCG_0375"
/db_xref="GeneID:4696203"
CDS 431119..432630
/locus_tag="BCG_0375"
/note="Differs from Rv0336 by 1aa, H496P"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976473.1"
/db_xref="GI:121636250"
/db_xref="GeneID:4696203"
/translation="MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAA
AQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRE
RLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLA
GQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSAL
AGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEA
ATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADF
VRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQ
QLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPK
RRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDHNDDPPPF"
misc_feature 431266..432135
/locus_tag="BCG_0375"
/note="Domain of unknown function (DUF222); Region:
DUF222; pfam02720"
/db_xref="CDD:202360"
misc_feature 432130..432273
/locus_tag="BCG_0375"
/note="HNH nucleases; HNH endonuclease signature which is
found in viral, prokaryotic, and eukaryotic proteins. The
alignment includes members of the large group of homing
endonucleases, yeast intron 1 protein, MutS, as well as
bacterial colicins, pyocins, and...; Region: HNHc;
cd00085"
/db_xref="CDD:28969"
misc_feature order(432181..432183,432187..432195,432199..432201,
432232..432237,432247..432252,432259..432261,
432271..432273)
/locus_tag="BCG_0375"
/note="active site"
/db_xref="CDD:28969"
gene complement(432800..434089)
/gene="aspC"
/locus_tag="BCG_0376c"
/db_xref="GeneID:4697963"
CDS complement(432800..434089)
/gene="aspC"
/locus_tag="BCG_0376c"
/EC_number="2.6.1.2"
/note="broad specificity; family IV; in Corynebacterium
glutamicum this protein can use glutamate,
2-aminobutyrate, and aspartate as amino donors and
pyruvate as the acceptor"
/codon_start=1
/transl_table=11
/product="aminotransferase"
/protein_id="YP_976474.1"
/db_xref="GI:121636251"
/db_xref="GeneID:4697963"
/translation="MDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGP
VHQHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSAR
RAVVTRYELVPGFPRFDVDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTAS
TSLAGGTPVHYLCDETQGWQPDIADLESKITERTKALVVINPNNPTGAVYSCEILTQM
VDLARKHQLLLLADEIYDKILYDDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGW
LAITGPKEHASSFIEGIGLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQ
RDIAWTKLNEIPGVSCVKPAGALYAFPRLDPEVYDIDDDEQLVLDLLLSEKILVTQGT
GFNWPAPDHLRLVTLPWSRDLAAAIERLGNFLVSYRQ"
misc_feature complement(432803..434017)
/gene="aspC"
/locus_tag="BCG_0376c"
/note="aminotransferase AlaT; Validated; Region: PRK09265"
/db_xref="CDD:181738"
misc_feature complement(432827..433912)
/gene="aspC"
/locus_tag="BCG_0376c"
/note="Aspartate aminotransferase family. This family
belongs to pyridoxal phosphate (PLP)-dependent aspartate
aminotransferase superfamily (fold I). Pyridoxal phosphate
combines with an alpha-amino acid to form a compound
called a Schiff base or aldimine...; Region: AAT_like;
cd00609"
/db_xref="CDD:99734"
misc_feature complement(order(433271..433273,433295..433300,
433304..433306,433385..433387,433478..433480,
433628..433630,433700..433708))
/gene="aspC"
/locus_tag="BCG_0376c"
/note="pyridoxal 5'-phosphate binding site [chemical
binding]; other site"
/db_xref="CDD:99734"
misc_feature complement(order(433160..433162,433169..433171,
433271..433279,433406..433408,433598..433600,
433697..433699))
/gene="aspC"
/locus_tag="BCG_0376c"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:99734"
misc_feature complement(433295..433297)
/gene="aspC"
/locus_tag="BCG_0376c"
/note="catalytic residue [active]"
/db_xref="CDD:99734"
gene complement(434120..436768)
/locus_tag="BCG_0377c"
/db_xref="GeneID:4695459"
CDS complement(434120..436768)
/locus_tag="BCG_0377c"
/EC_number="1.-.-.-"
/note="Differs from Rv0338c by 2aa, G506R, V621A"
/codon_start=1
/transl_table=11
/product="iron-sulfur-binding reductase"
/protein_id="YP_976475.1"
/db_xref="GI:121636252"
/db_xref="GeneID:4695459"
/translation="MTTQTLIRLILGMSMTAVVGVFALRRVWWLYKLVMSGQPASGRT
DNLGTRIWTQISEVLGQRRLLKWSIPGLAHFFTMWGFFILLTVYIEAYGLLFEERFHI
PVIGRWDALGFLQDFFATAVFLGITTFAIIRILRNPREIGRSSRFYGSHNGGAWLVLL
MIFNVIWTYVLVRGSAVNNGTLPYGNGAFLSQLFGAILRPLGQPANEIIETTALLLHI
GVMLAFLILVLHSKHLHIFLAPINVTFKRLPDGLGPLLPLEADGKPIDFENPSEDAVF
GRGKIEDFTWKGMLDFATCTECGRCQSQCPAWNTGKPLSPKLVIMDLRDHWMAKAPYI
LGQKDASAGGEAGHQEHHHVPESGFGRVPGHGPEQATRPLVGTEEQGGVIDPDVLWSC
VTCGACVEQCPVDIEHVDHIVDMRRYQVMMESEFPSELSVLFKNLETKGNPWGQNASD
RTNWIDEVDFDVPVYGQDVDSFDGYEYLFWVGCAGAYDDKAKKTTKAVAELLAVAGVK
YLVLGAGETCNGDSARRSGNEFLFQQLAQQAVETLDGLFEGVETVDRKIVVTCPHCFN
TIGKEYRQLGANYTVLHHTQLLNRLVRDKRLVPVTPVSQDITYHDPCYLGRHNKVYEA
PRELIGAAGASLTEMPRHADRSFCCGAGGARMWMEEHIGKRINHERVDEALATDATAI
ATACPFCRVMVTDGVNDRQEEAGRSGVEVLDVAQVLLGSLDHDKAQLPAKGTAAKQAQ
ERAPKAAPKAAAPVTPVEAPAEAPQAPAPAAPAAPVKGLGMAAGAKRPGAKKAAPTPA
APAAPAAPVKGLGIAAGAKRPGAKKTPPPAPGLAEPAAQPQPEAKPQPEPAAPPKPQT
DGDPAAPAAPVKGLGIARGARPPGKR"
misc_feature complement(434606..435916)
/locus_tag="BCG_0377c"
/note="Fe-S oxidoreductase [Energy production and
conversion]; Region: GlpC; COG0247"
/db_xref="CDD:223325"
misc_feature complement(435551..435622)
/locus_tag="BCG_0377c"
/note="4Fe-4S binding domain; Region: Fer4; pfam00037"
/db_xref="CDD:215671"
misc_feature complement(435062..435340)
/locus_tag="BCG_0377c"
/note="Cysteine-rich domain; Region: CCG; pfam02754"
/db_xref="CDD:202376"
misc_feature complement(434690..434950)
/locus_tag="BCG_0377c"
/note="Cysteine-rich domain; Region: CCG; pfam02754"
/db_xref="CDD:202376"
gene complement(436877..439375)
/locus_tag="BCG_0378c"
/db_xref="GeneID:4695752"
CDS complement(436877..439375)
/locus_tag="BCG_0378c"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976476.1"
/db_xref="GI:121636253"
/db_xref="GeneID:4695752"
/translation="MQHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVK
VLITGGIGTGKTTVLAAARDTLRRSGLTVLACPPPDGEPPETALVIDDAQLLTDTELL
RLTERVADSRLTVVAAAEAREHHRALRALTMALERDRPRISLGPLPVAEHLRDCTAGL
PFLIHAVSARAQAPAQAAKVALIERLRRLDEPTLDTLLMMSLTHELGVSDVAAALGIS
VTDARGLVDRAHASGLIESSHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDISP
VSAELALRLAEHGLRDERLADILTRYAADTRDASVRCARLYRAAVHAGAKGLTVRLAD
ALARTGDCTAAATLADDLLSSPDATERAAAVRVAASVAVHDGNTGHAAELFGWLGPHP
DTMVSSAATIVFAANGDLATARATLRLKDAGPPTMAARCARNLAEGLLLTMDQPYPVA
MAKLGQAIATEQSLSQVIPDSPAALVTLAAIHAGDPVRARSVIGRAVRAGADPLFQRR
HLLLSGWIKMQEGQLPSASADVAAASAGTHLHRRDALWAAALQTAISRRTGDIGALQQ
HWYAAMEALAEYSLDLFALLPLGELWVAAARMRQVDQLQHTLDQALTLLDSLGNPALW
SNSLHWAGVHAGILANSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDA
DEVTAAARSLSHVGLTSDATRLAGQAALQTSDARVSGAMLQLARDLKLGNDFGEPPSG
AGDTEPASGTPPAPRQPPAGSPLSDREREVAELLLLGMPYRDIGARLFISAKTVEHHV
ARIRQRLGAGSRSEMLSMLRAMLAPESLTADERR"
misc_feature complement(436922..437089)
/locus_tag="BCG_0378c"
/note="C-terminal DNA-binding domain of LuxR-like
proteins. This domain contains a helix-turn-helix motif
and binds DNA. Proteins belonging to this group are
response regulators; some act as transcriptional
activators, others as transcriptional repressors. Many...;
Region: LuxR_C_like; cd06170"
/db_xref="CDD:99777"
misc_feature complement(436940..>437089)
/locus_tag="BCG_0378c"
/note="Response regulator containing a CheY-like receiver
domain and an HTH DNA-binding domain [Signal transduction
mechanisms / Transcription]; Region: CitB; COG2197"
/db_xref="CDD:225107"
misc_feature complement(order(436946..436948,436979..436993,
436997..437002,437006..437011,437033..437041,
437078..437086))
/locus_tag="BCG_0378c"
/note="DNA binding residues [nucleotide binding]"
/db_xref="CDD:99777"
misc_feature complement(order(436922..436924,436931..436933,
436940..436948,437039..437041,437045..437047,
437051..437053))
/locus_tag="BCG_0378c"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:99777"
gene 439561..440100
/locus_tag="BCG_0379"
/db_xref="GeneID:4697829"
CDS 439561..440100
/locus_tag="BCG_0379"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976477.1"
/db_xref="GI:121636254"
/db_xref="GeneID:4697829"
/translation="MANSLLDFVISLVRDPEAAARYAANPERSIAEAHLTDVTRADVN
SLIPVVSDSLSMSEPIGAAGGAHAGDRGNVWASGAATAALDAFAPHADAGVVQQHGAV
GSVLNQPTPPGPGVTPTDPRPFRAGPHETSALLTSAEIPDTTSEDGGLPTDHPAVWNH
PVVDPHTVEPDHHGYDIHG"
gene 440289..441728
/gene="iniB"
/locus_tag="BCG_0380"
/db_xref="GeneID:4699344"
CDS 440289..441728
/gene="iniB"
/locus_tag="BCG_0380"
/codon_start=1
/transl_table=11
/product="isoniazid inductible gene protein iniB"
/protein_id="YP_976478.1"
/db_xref="GI:121636255"
/db_xref="GeneID:4699344"
/translation="MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISS
VAANVVPGLNLGAGDPMSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAG
LASGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGT
GLGAQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGA
GVGAGVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGA
ALNGAAMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAA
AGVVGGVGGATAAGVGGAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGG
TGGYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVTQPQHTPVEPPVHDKPPSHSVF
DVGHEPPVTHTPPAPIELPSYGLFGLPGF"
gene 441765..443687
/gene="iniA"
/locus_tag="BCG_0381"
/db_xref="GeneID:4697078"
CDS 441765..443687
/gene="iniA"
/locus_tag="BCG_0381"
/note="Differs from by 2aa, S88N, Q481H"
/codon_start=1
/transl_table=11
/product="isoniazid inductible gene protein iniA"
/protein_id="YP_976479.1"
/db_xref="GI:121636256"
/db_xref="GeneID:4697078"
/translation="MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTI
AIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLSSLLNLPAARVGDDE
ATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEV
GAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFV
RQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLN
DKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDP
NLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAE
RQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVL
SAELSPHVMGTDFGRLKALGRMESKPLRRGQKMIIGMRGSYGGVVMIGMLSSVVGLGL
FNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMI
QRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNL
AGLEPTLTPRASLGRA"
misc_feature 441765..443597
/gene="iniA"
/locus_tag="BCG_0381"
/note="Predicted GTPases (dynamin-related) [General
function prediction only]; Region: COG0699"
/db_xref="CDD:31043"
misc_feature <442263..442649
/gene="iniA"
/locus_tag="BCG_0381"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:213113"
misc_feature 442287..442298
/gene="iniA"
/locus_tag="BCG_0381"
/note="G3 box; other site"
/db_xref="CDD:206648"
misc_feature order(442293..442298,442356..442361)
/gene="iniA"
/locus_tag="BCG_0381"
/note="Switch II region; other site"
/db_xref="CDD:206648"
misc_feature order(442296..442298,442461..442466,442470..442472,
442557..442565)
/gene="iniA"
/locus_tag="BCG_0381"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206648"
misc_feature 442461..442472
/gene="iniA"
/locus_tag="BCG_0381"
/note="G4 box; other site"
/db_xref="CDD:206648"
misc_feature 442557..442565
/gene="iniA"
/locus_tag="BCG_0381"
/note="G5 box; other site"
/db_xref="CDD:206648"
gene 443684..445165
/gene="iniC"
/locus_tag="BCG_0382"
/db_xref="GeneID:4697077"
CDS 443684..445165
/gene="iniC"
/locus_tag="BCG_0382"
/codon_start=1
/transl_table=11
/product="isoniazid inductible gene protein iniC"
/protein_id="YP_976480.1"
/db_xref="GI:121636257"
/db_xref="GeneID:4697077"
/translation="MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEP
LRIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRA
NVPITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLR
LLVPADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAG
RIDAMLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAER
TELNRALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAA
ELLERSGLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLL
ADTHAFEELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRA
ALAAAQHWRRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR"
misc_feature 443693..444958
/gene="iniC"
/locus_tag="BCG_0382"
/note="Predicted GTPases (dynamin-related) [General
function prediction only]; Region: COG0699"
/db_xref="CDD:223771"
misc_feature 443816..>444256
/gene="iniC"
/locus_tag="BCG_0382"
/note="Rat sarcoma (Ras)-like superfamily of small
guanosine triphosphatases (GTPases); Region:
Ras_like_GTPase; cl17170"
/db_xref="CDD:247724"
misc_feature 443834..443857
/gene="iniC"
/locus_tag="BCG_0382"
/note="G1 box; other site"
/db_xref="CDD:206648"
misc_feature order(443840..443860,444119..444121)
/gene="iniC"
/locus_tag="BCG_0382"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206648"
misc_feature 443960..443962
/gene="iniC"
/locus_tag="BCG_0382"
/note="G2 box; other site"
/db_xref="CDD:206648"
misc_feature order(444002..444007,444017..444019)
/gene="iniC"
/locus_tag="BCG_0382"
/note="Switch I region; other site"
/db_xref="CDD:206648"
misc_feature 444110..444121
/gene="iniC"
/locus_tag="BCG_0382"
/note="G3 box; other site"
/db_xref="CDD:206648"
misc_feature order(444116..444121,444197..444202)
/gene="iniC"
/locus_tag="BCG_0382"
/note="Switch II region; other site"
/db_xref="CDD:206648"
gene complement(445308..445868)
/gene="lpqJ"
/locus_tag="BCG_0383c"
/db_xref="GeneID:4697432"
CDS complement(445308..445868)
/gene="lpqJ"
/locus_tag="BCG_0383c"
/codon_start=1
/transl_table=11
/product="lipoprotein lpqJ"
/protein_id="YP_976481.1"
/db_xref="GI:121636258"
/db_xref="GeneID:4697432"
/translation="MRLSLIARGMAALLAATALVAGCNTTIDGRPVASPGSGPTEPTF
PTPRPTTAPPGTTAPTLPTTPVSPTAPAGAIPLPPDSNGYVFIETKSGMTRCQINRDS
VGCEAPFTNSPLRDGEHANGIHITAGGSVQWVLGNLGAIPTVSIDYRTYEAQGWTIDA
TTDGTRFTNNRTGHGMFVSIEKVDTF"
gene 445977..446387
/locus_tag="BCG_0384"
/db_xref="GeneID:4698157"
CDS 445977..446387
/locus_tag="BCG_0384"
/note="In Mycobacterium bovis, a frameshift due to a
single base deletion (a-*) leads to a shorter product with
a different NH2 part compared to its homolog in
Mycobacterium tuberculosis strain H37Rv in Mycobacterium
bovis BCG Pasteur"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976482.1"
/db_xref="GI:121636259"
/db_xref="GeneID:4698157"
/translation="MLPSTVVGVLLAAGAGRWYGKPKVLVDGWLDTAVGALRDGGCND
VILVLGAVEVSAPAGVTAITAPDWQQGLSASVRAGLAQADREHADYAVLHVIDTPDVN
AKVVARVLGRALVSRSGLAGRGRIPAHSARRRGC"
misc_feature 445977..>446315
/locus_tag="BCG_0384"
/note="Uncharacterized MobA-related protein [General
function prediction only]; Region: COG2068"
/db_xref="CDD:224979"
misc_feature order(446007..446009,446013..446015,446115..446117,
446259..446261,446265..446267)
/locus_tag="BCG_0384"
/note="active site"
/db_xref="CDD:132997"
gene complement(446429..447892)
/gene="ansP2"
/locus_tag="BCG_0385c"
/db_xref="GeneID:4695803"
CDS complement(446429..447892)
/gene="ansP2"
/locus_tag="BCG_0385c"
/standard_name="aroP2"
/codon_start=1
/transl_table=11
/product="l-asparagine permease ansP2"
/protein_id="YP_976483.1"
/db_xref="GI:121636260"
/db_xref="GeneID:4695803"
/translation="MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGA
GGRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVA
GWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGE
LEFWASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVT
SGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAY
KEHVSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRF
TAPMSKTGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQ
LRLHRMANAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGV
PALIGGWYLVRNRVTAVAHHAIDHTKSVAVVHSADPI"
misc_feature complement(446474..447868)
/gene="ansP2"
/locus_tag="BCG_0385c"
/note="Gamma-aminobutyrate permease and related permeases
[Amino acid transport and metabolism]; Region: AnsP;
COG1113"
/db_xref="CDD:224038"
gene 448231..449217
/locus_tag="BCG_0386"
/db_xref="GeneID:4697141"
CDS 448231..449217
/locus_tag="BCG_0386"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976484.1"
/db_xref="GI:121636261"
/db_xref="GeneID:4697141"
/translation="MPGARELTLRVERGALFRRRWAASAASSARAAIRRDPRRCALGT
RPRWVSFLVIVLVIMNVVTAHPKYPNDPLALVLIELRHPRTEPPVPSAISILKEELAR
WTPILEQEEVRQVNLETGEHTAHSQKKLVARDRRTAITFRPDAMTLEVTDYPGWEEFR
SIVHAMVTARQDVAPVDGCIRIGLRYINEIRASLAEPSGWAYWVAESLLGPGTQLADL
KLTTTAQRHVIQCEGPEPGDSLTLRYAGARGAVIQSTPFLQRLKEPPAEGDFFLIDID
SAWSDPCKGIPALDAHLVDEVAERLHTPIGPLFESLITSELRTKVLQQPGQE"
misc_feature 448429..449190
/locus_tag="BCG_0386"
/note="TIGR04255 family protein; Region: sporadTIGR04255"
/db_xref="CDD:234524"
gene 449220..449873
/locus_tag="BCG_0387"
/db_xref="GeneID:4695384"
CDS 449220..449873
/locus_tag="BCG_0387"
/codon_start=1
/transl_table=11
/product="transcriptional regulatory protein"
/protein_id="YP_976485.1"
/db_xref="GI:121636262"
/db_xref="GeneID:4695384"
/translation="MTISFSSSNLRDDATSGNGDYRLDKLPETTPSTSVFDRADVTYR
QFTELHGQARDTRREAHVVELESKTGERARCAPMHALEQLADYGFAWRDIARVVGVSV
PAITKWRKGAGVTGENRLKIARLLALIDMLSDRFIGEPASWLEMPIQAGVGITRMDLL
ERGRYDLVLALASTHTGDGTVEYVLNETDKDWRETVVDNAFESYTAEDGVISIRPKR"
gene 449876..450535
/locus_tag="BCG_0388"
/db_xref="GeneID:4695917"
CDS 449876..450535
/locus_tag="BCG_0388"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976486.1"
/db_xref="GI:121636263"
/db_xref="GeneID:4695917"
/translation="MPELETPDDPESIYLARLEDVGEHRPTFTGDIYRLGDGRMVMIL
QHPCALRHGVDLHPRLLVAPVRPDSLRSNWARAPFGTMPLPKLIDGQDHSADFINLEL
IDSPTLPTCERIAVLSQSGVNLVMQRWVYHSTRLAVPTHTYSDSTVGPFDEADLIEEW
VTDRVDDGADPQAAEHECASWLDERISGRTRRALLSDRQHASSIRREARSHRKSVKLA
D"
gene 450762..452639
/gene="dnaK"
/locus_tag="BCG_0389"
/db_xref="GeneID:4697869"
CDS 450762..452639
/gene="dnaK"
/locus_tag="BCG_0389"
/EC_number="3.6.1.-"
/standard_name="hsp70"
/note="heat shock protein 70; assists in folding of
nascent polypeptide chains; refolding of misfolded
proteins; utilizes ATPase activity to help fold;
co-chaperones are DnaJ and GrpE; multiple copies in some
bacteria"
/codon_start=1
/transl_table=11
/product="molecular chaperone DnaK"
/protein_id="YP_976487.1"
/db_xref="GI:121636264"
/db_xref="GeneID:4697869"
/translation="MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFAR
NGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRD
AEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKG
EKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKG
TSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRA
EFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKE
PNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTI
PTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTF
DIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEAD
VRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSA
MEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREA
K"
misc_feature 450762..452486
/gene="dnaK"
/locus_tag="BCG_0389"
/note="molecular chaperone DnaK; Provisional; Region:
dnaK; PRK00290"
/db_xref="CDD:234715"
misc_feature 450762..451790
/gene="dnaK"
/locus_tag="BCG_0389"
/note="Nucleotide-binding domain of human HSPA9 and
similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234"
/db_xref="CDD:212676"
misc_feature order(450789..450800,450969..450971,451200..451202,
451275..451280,451284..451286,451362..451364,
451476..451478,451485..451487,451497..451499,
451701..451709,451713..451715)
/gene="dnaK"
/locus_tag="BCG_0389"
/note="nucleotide binding site [chemical binding]; other
site"
/db_xref="CDD:212676"
misc_feature order(450843..450845,450852..450854,450906..450908,
450918..450920,450927..450932,450936..450941,
451074..451085,451446..451448,451455..451460,
451467..451469,451521..451523,451527..451532)
/gene="dnaK"
/locus_tag="BCG_0389"
/note="NEF interaction site [polypeptide binding]; other
site"
/db_xref="CDD:212676"
misc_feature order(451131..451136,451140..451145,451188..451193,
451197..451199,451323..451334)
/gene="dnaK"
/locus_tag="BCG_0389"
/note="SBD interface [polypeptide binding]; other site"
/db_xref="CDD:212676"
gene 452636..453343
/gene="grpE"
/locus_tag="BCG_0390"
/db_xref="GeneID:4699017"
CDS 452636..453343
/gene="grpE"
/locus_tag="BCG_0390"
/note="with DnaK and DnaJ acts in response to hyperosmotic
and heat shock by preventing the aggregation of
stress-denatured proteins; may act as a thermosensor"
/codon_start=1
/transl_table=11
/product="heat shock protein GrpE"
/protein_id="YP_976488.1"
/db_xref="GI:121636265"
/db_xref="GeneID:4699017"
/translation="MTDGNQKPDGNSGEQVTVTDKRRIDPETGEVRHVPPGDMPGGTA
AADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDL
ERARKHGDLESGPLKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGS
KPVIGTVMRQGYQLGEQVLRHALVGVVDTVVVDAAELESVDDGTAVADTAENDQADQG
NSADTLGEQAESEPSGS"
misc_feature 452669..453184
/gene="grpE"
/locus_tag="BCG_0390"
/note="Molecular chaperone GrpE (heat shock protein)
[Posttranslational modification, protein turnover,
chaperones]; Region: GrpE; COG0576"
/db_xref="CDD:30921"
misc_feature 452798..453184
/gene="grpE"
/locus_tag="BCG_0390"
/note="GrpE is the adenine nucleotide exchange factor of
DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the
ATPase domain of Hsp70 catalyzing the dissociation of ADP,
which enables rebinding of ATP, one step in the Hsp70
reaction cycle in protein folding; Region: GrpE; cd00446"
/db_xref="CDD:73207"
misc_feature order(452804..452809,452816..452821,452828..452830,
452840..452842,452849..452854,452894..452896,
452906..452908,452915..452917,452936..452938,
452948..452950,452981..452983,452990..452992,
453023..453025)
/gene="grpE"
/locus_tag="BCG_0390"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:73207"
misc_feature order(452855..452857,453065..453067,453074..453088,
453137..453139,453164..453166,453176..453178)
/gene="grpE"
/locus_tag="BCG_0390"
/note="hsp70 (ATPase domain) interactions [polypeptide
binding]; other site"
/db_xref="CDD:73207"
gene 453379..454566
/gene="dnaJ1"
/locus_tag="BCG_0391"
/db_xref="GeneID:4697812"
CDS 453379..454566
/gene="dnaJ1"
/locus_tag="BCG_0391"
/standard_name="dnaJ"
/note="chaperone Hsp40; co-chaperone with DnaK;
Participates actively in the response to hyperosmotic and
heat shock by preventing the aggregation of
stress-denatured proteins and by disaggregating proteins,
also in an autonomous, dnaK-independent fashion"
/codon_start=1
/transl_table=11
/product="chaperone protein DnaJ"
/protein_id="YP_976489.1"
/db_xref="GI:121636266"
/db_xref="GeneID:4697812"
/translation="MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPG
NPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVG
GDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVE
AAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTD
CRGSGSIIEHPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGD
LYVAVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGTVGVRVPKGTADGR
ILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWA
GNR"
misc_feature 453379..454557
/gene="dnaJ1"
/locus_tag="BCG_0391"
/note="chaperone protein DnaJ; Provisional; Region:
PRK14279"
/db_xref="CDD:184601"
misc_feature 453406..453570
/gene="dnaJ1"
/locus_tag="BCG_0391"
/note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
protein 40) proteins are highly conserved and play crucial
roles in protein translation, folding, unfolding,
translocation, and degradation. They act primarily by
stimulating the ATPase activity of Hsp70s; Region: DnaJ;
cd06257"
/db_xref="CDD:99751"
misc_feature order(453490..453498,453523..453525,453532..453537,
453544..453549)
/gene="dnaJ1"
/locus_tag="BCG_0391"
/note="HSP70 interaction site [polypeptide binding]; other
site"
/db_xref="CDD:99751"
misc_feature 453907..454080
/gene="dnaJ1"
/locus_tag="BCG_0391"
/note="Zinc finger domain of DnaJ and HSP40; Region:
DnaJ_zf; cd10719"
/db_xref="CDD:199908"
misc_feature order(453907..453909,453916..453918,453958..453960,
453967..453969,454024..454026,454033..454035,
454066..454068,454075..454077)
/gene="dnaJ1"
/locus_tag="BCG_0391"
/note="Zn binding sites [ion binding]; other site"
/db_xref="CDD:199908"
misc_feature <454126..454473
/gene="dnaJ1"
/locus_tag="BCG_0391"
/note="C-terminal substrate binding domain of DnaJ and
HSP40; Region: DnaJ_C; cd10747"
/db_xref="CDD:199909"
misc_feature order(454288..454293,454300..454305,454363..454374,
454459..454473)
/gene="dnaJ1"
/locus_tag="BCG_0391"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:199909"
gene 454566..454946
/gene="hspR"
/locus_tag="BCG_0392"
/db_xref="GeneID:4699347"
CDS 454566..454946
/gene="hspR"
/locus_tag="BCG_0392"
/codon_start=1
/transl_table=11
/product="heat shock protein transcriptional regulator
HspR"
/protein_id="YP_976490.1"
/db_xref="GI:121636267"
/db_xref="GeneID:4699347"
/translation="MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTS
GGGRRYSLHDVELLRQVQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVL
RANQRREVAVVPKSTALVVWKPRR"
misc_feature 454599..454892
/gene="hspR"
/locus_tag="BCG_0392"
/note="Helix-Turn-Helix DNA binding domain of HspR-like
transcription regulators; Region: HTH_HspR-like; cd01279"
/db_xref="CDD:133387"
misc_feature order(454605..454613,454653..454655,454701..454709)
/gene="hspR"
/locus_tag="BCG_0392"
/note="DNA binding residues [nucleotide binding]"
/db_xref="CDD:133387"
misc_feature 454608..454805
/gene="hspR"
/locus_tag="BCG_0392"
/note="MerR HTH family regulatory protein; Region: MerR_1;
pfam13411"
/db_xref="CDD:205589"
misc_feature order(454743..454745,454752..454754,454767..454772,
454797..454799,454827..454829,454839..454841,
454857..454859,454869..454871,454878..454883)
/gene="hspR"
/locus_tag="BCG_0392"
/note="putative dimer interface [polypeptide binding];
other site"
/db_xref="CDD:133387"
gene complement(454969..465492)
/gene="PPE8"
/locus_tag="BCG_0393c"
/db_xref="GeneID:4696301"
CDS complement(454969..465492)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="In Mycobacterium tuberculosis strain H37Rv, PPE7
and PPE8 exist as 2 genes. In Mycobacterium bovis BCG
Pasteur, and Mycobacterium bovis, a 2 bp insertion (*-ta)
resulting in the absence of a stop codon between the 2
genes, leads to a single product, and an altered
C-terminus"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976491.1"
/db_xref="GI:121636268"
/db_xref="GeneID:4696301"
/translation="MSFAVLPPEINSARLYVGAGLAPMLDAAAAWDGLADELGSAAAS
FSAVTAGLAGSSWLGAASTAMTGAAAPYLGWLSAAAAQAQQAATQTRLAAAAFEAALA
ATVHPAIISANRALFVSLVVSNLLGQNAPAIAATEAAYEQMWAQDVAAMFGYHAGASA
AVSALTPFGQALPTVAGGGALVSAAAAQVTTRVFRNLGLANVGEGNVGNGNVGNFNLG
SANIGNGNIGSGNIGSSNIGFGNVGPGLTAALNNIGFGNTGSNNIGFGNTGSNNIGFG
NTGDGNRGIGLTGSGLLGFGGLNSGTGNIGLFNSGTGNVGIGNSGTGNWGIGNSGNSY
NTGFGNSGDANTGFFNSGIANTGVGNAGNYNTGSYNPGNSNTGGFNMGQYNTGYLNSG
NYNTGLANSGNVNTGAFITGNFNNGFLWRGDHQGLIFGSPGFFNSTSAPSSGFFNSGA
GSASGFLNSGANNSGFFNSSSGAIGNSGLANAGVLVSGVINSGNTVSGLFNMSLVAIT
TPALISGFFNTGSNMSGFFGGPPVFNLGLANRGVVNILGNANIGNYNILGSGNVGDFN
ILGSGNLGSQNILGSGNVGSFNIGSGNIGVFNVGSGSLGNYNIGSGNLGIYNIGFGNV
GDYNVGFGNAGDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNIASGWNSGTG
NSGLFNSGTNNVGIFNAGTGNVGIANSGTGNWGIGNPGTDNTGILNAGSYNTGILNAG
DFNTGFYNTGSYNTGGFNVGNTNTGNFNVGDTNTGSYNPGDTNTGFFNPGNVNTGAFD
TGDFNNGFLVAGDNQGQIAIDLSVTTPFIPINEQMVIDVHNVMTFGGNMITVTEASTV
FPQTFYLSGLFFFGPVNLSASTLTVPTITLTIGGPTVTVPISIVGALESRTITFLKID
PAPGIGNSTTNPSSGFFNSGTGGTSGFQNVGGGSSGVWNSGLSSAIGNSGFQNLGSLQ
SGWANLGNSVSGFFNTSTVNLSTPANVSGLNNIGTNLSGVFRGPTGTIFNAGLANLGQ
LNIGSANLGDFNLGSGNVGSFNVFSGNQGSYNIGPANLGNYNIGFANLGNYNIGFGNA
GDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGTANIGLFNSGTN
NVGIGNSGTGNWGIGNSGSGNTGIGNTGSTNTGFFNTGIVNTGVANAGSYNTGWYNTG
DTNTGIANLGDFNTGFYNTGNFSTGFANQGDIATGAFITGDMGNGAFWRGDQQGLFSA
GYRVHVPEIPAHVTVEVPVNIPITASFTNTVYSGITLEQINFGFTIDIAGIPLLAGAI
SKAVLPPITGTGPAITVNIGDPGGSTAIRIPATASVGPFDVTFVNIAATTGFFNATTD
PSSGFFNGGPGTVSGIANIGANISGFQNVANSATSGFNNYGSLQSGLANLGDTVSGVF
NTGIGAPANVSGMFNIGSNLAGFFHDQATGMSMFNLGLGNIGQFNVGFSNVGDSNAGL
ANIGSFNLGSGNLGSFNVFGGNQGSYNIGPANLGNYNIGLGNLGSYNFGFGNAGDFNL
GFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGSGNSGLFNSGTNNIGLF
NSGTGNIGIGNSGTGNWGIANTGDTNTGIFNTGDVNTGLLNAGNVNTGIFNTGHYNTG
SFNAGSFNTAGFNPGSYNTGYLNTGSYNTGLANSGDVNTGGFITGNYSNGFWWRGDYQ
GLAGISQTITVPDTAVPVKLHVPIFLDIPVTGTLGTFTVHGFRFPEITGDIFLIGIPF
NAATLDAFSFPNISIVLPNIGINLGSGPDPLIDIAGTGGLLPIKIPLIDIPAAPGFGN
STTTPSSGFFNAGTGTVSGVGNVGSNSSGFFNLTSGSSGISGVQNFGELISGGFNFGN
TVSGLVNASTLGLSMPANLSGGGNVGATVAGFVNNTQILNLGFGNVGSGNVGHGNIGD
SNVGLGNLGNANVGHGNIGSFNVFSGNRGSYNIGPANLGNYNIGLGNLGSYNFGFGNA
GDFNLGFANSGSNNIGFANTGNNNIGIGLSGHNQQGFGSWNSGTANTGLFNSGTNNIG
LFNSGTGNIGIGNSGIGNTGIGNPGVGNTGLGNSGTGNWGLWNPGTGNMGVANVGTYN
TGGYNVGSTNTGIANVGIANTGSYNTGSTNTGSFNDGDFNTGFYNTGDYNTGFYNTGD
VNTGAFIGGNFSNGAFWQSDHQGQWGAHYAITVPQIPLLNFSLNIPVNIPIHLDFGTL
AVNGFQIPAITLRALGVTHFSVGPIIVPRIAGTLPVIDINIGDPGGSSSIPITITSGA
GPVVIPLLDIPPAPGFGNSTTGPSSGFFNSGTGSSSGFGNVGANNSGFWNTAFAGIGN
SGLQNFGSLQSGWANLGNTVSGFYNTSAADFATPANLSGLSNVGADLTGVLRGPNGST
FNAGLANLGQFNVGSANLGSANLGSANLGNSNVGFGNIGNANIGGANIGDFNVGIANT
GPGLTAAVNNIGIGNTGNYNIGVGNTGNYNIGFGNTGNNNIGIGLSGDNQIGFGPLNA
GIANMGLFNLGDNNFGMANAGNFNQGIANTGNNNIGLFNTGNNNVGIGLTGDGLSGFS
SLNSGAGNTGFFNSGTANTGLFNSGTGNTGLFNSGTGNVGIGNMGTGGFGVGLSGDSQ
VGIGGTNSGSFNIGLFNSGTGNVGIGNSGTGNVGIGNTGTGNTGIGNSGNYNTGLLNA
GLVNTGIANPGNHNTGLFNIGTFNTGIANPGHYNTGSYNTGSYNTGMANAGDYGTGAF
ITGSMNNGLLWRADRQGLLAANYTITIERPAAFLNVDIPVNIPITGDITNVSIPAITF
PRIDASGSVDIGILSGTVLAPVGPITLHGGDASAPLDTPIEIDFGPSPAINLNIGKPD
GSTVINIVGGAGAGPISIPIIDLRPAPGFFNATTGPSSGFLNWGAGSASGLLNFGNNS
GLYNFATSSMGNSGFQNYGSLQSGWANLGNSISGIYNTGLGAPANVSGLLNIGTNLAG
WLQNGPTETTFSVGLANLGFWNLGSANIGNYNLGSANIGVYNLGSANIGDFNLGSANI
GDFNLGSANIGSSNIGFGNVGPGLTAAIGNIGFGNTGNGNIGIGNTGTGNIGFGNTGN
GNIGIGLTGDTMTGFGGWNSGTGNIGLFNSGTGNIGFGNSGTGNWGIGNSGDYNTGIG
NTGSTNSGFFNTGLVNTGIGNSGDYNTGLFNAGNTNTGSFNPGDYNTGGFNPGNYNTG
YFNPGNSNTGFANSGDVNTGAFNSGNYSNGFFWRGDYQGLGGFAYQSAVSEIPWSYDI
GSNIEIPIEGDINAITQDAFTIDEFEIPIKLRVSVCVIYIPFKGCVKHVSVTIPITTE
HLGPYEIDASTINPDQPIDTAFTQTLDFAGSGTVGAFPFGFGWQQSPGFFNSTTTPSS
GFFNSGAGGASGFLNDAAAAVSGLGNVFTETSGFFNAGGVGNSGFQNFGNLLSGWANL
GNTVSGFYNTSMLDLATQALISGFGNHGARLSGILNNGSGP"
misc_feature complement(465004..465480)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="PPE family; Region: PPE; pfam00823"
/db_xref="CDD:189731"
misc_feature complement(464374..464490)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(463630..463749)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(461818..461934)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(460321..>460614)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:35210"
misc_feature complement(460471..460590)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(456292..456411)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(455983..456102)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(455803..455919)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
misc_feature complement(455713..455829)
/gene="PPE8"
/locus_tag="BCG_0393c"
/note="Pentapeptide repeats (8 copies); Region:
Pentapeptide_2; pfam01469"
/db_xref="CDD:201813"
gene complement(465643..466287)
/locus_tag="BCG_0394c"
/db_xref="GeneID:4696417"
CDS complement(465643..466287)
/locus_tag="BCG_0394c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976492.1"
/db_xref="GI:121636269"
/db_xref="GeneID:4696417"
/translation="MTDASVHPDELDPEYHHHGGFPEYGPASPGAGFGQFVATMRRLQ
DLAVAADPGDAVWDEAAERAAALVELLSPFEADEGKAPAGRTPGLPGMGSLLLPPWTV
TRYGTDGVEMRGSFSRFHVGGNSAVHGGVLPLLFDHMFGMISHAAGRPISRTAFLHVD
YRRITPIDVPLIVRGRVTNTEGRKAFVCAELFDSDETLLAEGNGLMVRLLPGQP"
misc_feature complement(465664..465987)
/locus_tag="BCG_0394c"
/note="PaaI_thioesterase is a tetrameric acyl-CoA
thioesterase with a hot dog fold and one of several
proteins responsible for phenylacetic acid (PA)
degradation in bacteria. Although orthologs of PaaI exist
in archaea and eukaryotes, their function has not...;
Region: PaaI_thioesterase; cd03443"
/db_xref="CDD:239527"
misc_feature complement(order(465796..465807,465826..465828,
465907..465909))
/locus_tag="BCG_0394c"
/note="CoenzymeA binding site [chemical binding]; other
site"
/db_xref="CDD:239527"
misc_feature complement(order(465805..465807,465811..465825,
465889..465891,465898..465900,465904..465906))
/locus_tag="BCG_0394c"
/note="subunit interaction site [polypeptide binding];
other site"
/db_xref="CDD:239527"
misc_feature complement(order(465826..465828,465862..465867,
465874..465879,465901..465903))
/locus_tag="BCG_0394c"
/note="PHB binding site; other site"
/db_xref="CDD:239527"
gene complement(466284..467582)
/gene="purA"
/locus_tag="BCG_0395c"
/db_xref="GeneID:4696674"
CDS complement(466284..467582)
/gene="purA"
/locus_tag="BCG_0395c"
/EC_number="6.3.4.4"
/note="catalyzes the formation of
N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine
monophosphate and GTP in AMP biosynthesis"
/codon_start=1
/transl_table=11
/product="adenylosuccinate synthetase"
/protein_id="YP_976493.1"
/db_xref="GI:121636270"
/db_xref="GeneID:4696674"
/translation="MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVV
LPTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISAD
AHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHK
VEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETV
LLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSG
PFPTELFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDV
LSSLESVPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPA
KARDYVLRLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP"
misc_feature complement(466314..467576)
/gene="purA"
/locus_tag="BCG_0395c"
/note="Adenylosuccinate synthetase; Region:
Adenylsucc_synt; smart00788"
/db_xref="CDD:197875"
misc_feature complement(466335..467576)
/gene="purA"
/locus_tag="BCG_0395c"
/note="Adenylosuccinate synthetase (AdSS) catalyzes the
first step in the de novo biosynthesis of AMP. IMP and
L-aspartate are conjugated in a two-step reaction
accompanied by the hydrolysis of GTP to GDP in the
presence of Mg2+. In the first step, the...; Region: AdSS;
cd03108"
/db_xref="CDD:239382"
misc_feature complement(order(466335..466340,466584..466586,
466590..466592,467451..467453,467457..467465,
467532..467540,467544..467546))
/gene="purA"
/locus_tag="BCG_0395c"
/note="GDP-binding site [chemical binding]; other site"
/db_xref="CDD:239382"
misc_feature complement(order(467460..467462,467529..467531,
467538..467540))
/gene="purA"
/locus_tag="BCG_0395c"
/note="ACT binding site; other site"
/db_xref="CDD:239382"
misc_feature complement(order(466866..466868,466911..466913,
467196..467198,467205..467207,467469..467471))
/gene="purA"
/locus_tag="BCG_0395c"
/note="IMP binding site; other site"
/db_xref="CDD:239382"
gene 467673..468320
/locus_tag="BCG_0396"
/db_xref="GeneID:4699225"
CDS 467673..468320
/locus_tag="BCG_0396"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976494.1"
/db_xref="GI:121636271"
/db_xref="GeneID:4699225"
/translation="MYTAENAPGVAVLLSGDADVPGPLTGLPTHQDNLDTVIGRYSRL
IVVGADADLGAVLTRLLRTDRLDVEVGYVPRRRSPATRAYRLPAGRRAARRARCGVAR
RVPLIRDETGSVIVGRAQWLPAEEQALIHGEAVVDDTVLFDGDVAGVCIEPTLTLPGL
RAAVDGAGKWRRWIGGRAAQLGTTGAAVLRDGVAAPRPVRRSTFYRNVEGWLLVR"
gene 468331..469110
/locus_tag="BCG_0397"
/db_xref="GeneID:4697373"
CDS 468331..469110
/locus_tag="BCG_0397"
/note="Differs from Rv0359 by 1aa, T252A"
/codon_start=1
/transl_table=11
/product="integral membrane protein"
/protein_id="YP_976495.1"
/db_xref="GI:121636272"
/db_xref="GeneID:4697373"
/translation="MSETGQRESVRPSPIFLGLLGLTAVGGALAWLAGETVQPLAYAG
VFVMVIAGWLVSLCLHEFGHAFTAWRFGDHDVAVRGYLTLDPRRYSHPMLSLGLPMLF
IALGGIGLPGAAVYVHTWFMTTARRTLVSLAGPTVNLALAMLLLAATRLLFDPIHAVL
WAGVAFLAFLQLTALVLNLLPIPGLDGYAALEPHLRPETQRALAPAKQFALVFLLVLF
LAPTLNGWFFGVVYWLFDLSGVSHRLAAAGSVLTRFWSIWF"
misc_feature 468466..468954
/locus_tag="BCG_0397"
/note="Uncharacterized homologs of Site-2 protease (S2P),
zinc metalloproteases (MEROPS family M50) which cleave
transmembrane domains of substrate proteins, regulating
intramembrane proteolysis (RIP) of diverse signal
transduction mechanisms. Members of the...; Region:
S2P-M50_like_1; cd06158"
/db_xref="CDD:100079"
misc_feature 468472..468954
/locus_tag="BCG_0397"
/note="Peptidase family M50; Region: Peptidase_M50;
pfam02163"
/db_xref="CDD:216910"
misc_feature order(468508..468513,468520..468522,468862..468864,
468886..468888)
/locus_tag="BCG_0397"
/note="active site"
/db_xref="CDD:100079"
misc_feature 468862..468873
/locus_tag="BCG_0397"
/note="putative substrate binding region [chemical
binding]; other site"
/db_xref="CDD:100079"
gene complement(469115..469552)
/locus_tag="BCG_0398c"
/db_xref="GeneID:4696939"
CDS complement(469115..469552)
/locus_tag="BCG_0398c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976496.1"
/db_xref="GI:121636273"
/db_xref="GeneID:4696939"
/translation="MTKRTITPMTSMGDLLGPEPILLPGDSDAEAELLANESPSIVAA
AHPSASVAWAVLAEGALADDKTVTAYAYARTGYHRGLDQLRRHGWKGFGPVPYSHQPN
RGFLRCVAALARAAAAIGETDEYGRCLDLLDDCDPAARPALGL"
misc_feature complement(469178..469510)
/locus_tag="BCG_0398c"
/note="Protein of unknown function (DUF3151); Region:
DUF3151; pfam11349"
/db_xref="CDD:221088"
gene 469635..470462
/locus_tag="BCG_0399"
/db_xref="GeneID:4696308"
CDS 469635..470462
/locus_tag="BCG_0399"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976497.1"
/db_xref="GI:121636274"
/db_xref="GeneID:4696308"
/translation="MSNAPEPDRSAGESGSEPAGERSADPGEERTESYPLVPHDAETE
TVVITTSDNDAAVTQPEAQRERRFTAPGFDAKETQVIVTAHEAATEVFQTNQAPTTPP
RMPTGMPPKTAVPQSIPPRTEATSVRQRTWGWALAVVVIVLALAAIAILGTVLLTRGK
HSKMSQEDQVRQAIQSLDIAIQTGDLTALRSLTCGSTRDGYVDYDERDWAETYRRVSA
AKQYPVIASIDQVVVNGAHAEANVTTFMAFDPQVRSTRSLDLQFRDDQWKICQSSSN"
gene 470684..472066
/gene="mgtE"
/locus_tag="BCG_0400"
/db_xref="GeneID:4695690"
CDS 470684..472066
/gene="mgtE"
/locus_tag="BCG_0400"
/note="Differs from Rv0362 by 1aa, V292A"
/codon_start=1
/transl_table=11
/product="Mg2+ transport transmembrane protein mgtE"
/protein_id="YP_976498.1"
/db_xref="GI:121636275"
/db_xref="GeneID:4695690"
/translation="MSIRPAENSTLDIRHVIGIGTPKAVDLWLDVVTELPDRARELGS
LSKAELGKLGPLLDGTNAVELFESIDDKLAAEALHAMDPSLAATFLEALDSDHAANIL
REFKEPKREALLTLLPLERAMVLRGLLSWPEDCAAAHMVPETLTVRPNMTVSQAVASV
RERASGLRSDARTTAYVYVTDADSHLLGVIAFRALVLANPEQRVRELMGDDLIVVSPL
TDKELAAQTIMGHNLMAVPVVDADNRLLGIIAEDEAIDIAEEEATEDAERQGGSAPLE
VPYLRASPWLLWRKRVVWLLVLFAAEAYTGSVLRAFSDEMEAVIALAFFIPLLIGTGG
NTGTQIATTLVRAMATGQVRFRDVPAVLAKELSTGVLVGLTMAAAAVVRAWTLGVGPQ
VTLTVALTVAAIVVWSSLVAAVLPPLLKKLRIDPAIVSGPMIATIVDGTGLLIYFLVA
HLTLTELHGL"
misc_feature 470696..472057
/gene="mgtE"
/locus_tag="BCG_0400"
/note="Mg/Co/Ni transporter MgtE (contains CBS domain)
[Inorganic ion transport and metabolism]; Region: MgtE;
COG2239"
/db_xref="CDD:225148"
misc_feature 470792..471085
/gene="mgtE"
/locus_tag="BCG_0400"
/note="MgtE intracellular N domain; Region: MgtE_N;
pfam03448"
/db_xref="CDD:146204"
misc_feature 471119..471424
/gene="mgtE"
/locus_tag="BCG_0400"
/note="This cd contains two tandem repeats of the
cystathionine beta-synthase (CBS pair) domain in the
magnesium transporter, MgtE. MgtE and its homologs are
found in eubacteria, archaebacteria, and eukaryota.
Members of this family transport Mg2+ or other...; Region:
CBS_pair_Mg_transporter; cd04606"
/db_xref="CDD:239979"
misc_feature 471656..472033
/gene="mgtE"
/locus_tag="BCG_0400"
/note="Divalent cation transporter; Region: MgtE;
pfam01769"
/db_xref="CDD:110745"
gene complement(472078..473112)
/gene="fba"
/locus_tag="BCG_0401c"
/db_xref="GeneID:4699000"
CDS complement(472078..473112)
/gene="fba"
/locus_tag="BCG_0401c"
/EC_number="4.1.2.13"
/standard_name="fda"
/note="catalyzes the formation of glycerone phosphate and
glyceraldehyde 3-phosphate from fructose 1,6,
bisphosphate"
/codon_start=1
/transl_table=11
/product="fructose-bisphosphate aldolase"
/protein_id="YP_976499.1"
/db_xref="GI:121636276"
/db_xref="GeneID:4699000"
/translation="MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADA
GSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKL
DSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEI
EIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPG
NVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVD
TDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACND
LHCAGKSLTH"
misc_feature complement(472087..473112)
/gene="fba"
/locus_tag="BCG_0401c"
/note="fructose-bisphosphate aldolase; Provisional;
Region: PRK09197"
/db_xref="CDD:236406"
misc_feature complement(472090..473106)
/gene="fba"
/locus_tag="BCG_0401c"
/note="fructose-bisphosphate aldolase, class II, yeast/E.
coli subtype; Region: FruBisAldo_II_A; TIGR01520"
/db_xref="CDD:130583"
misc_feature complement(order(472282..472287,472291..472293,
472348..472350,472354..472359,472468..472470,
472474..472482,472606..472617,472624..472626,
472630..472632,472720..472722,472825..472830,
473032..473034))
/gene="fba"
/locus_tag="BCG_0401c"
/note="active site"
/db_xref="CDD:238255"
misc_feature complement(order(472240..472242,472249..472251,
472261..472263,472270..472275,472279..472284,
472606..472608,472867..472872,472879..472881,
472891..472893,472930..472938,472945..472947,
473008..473010,473017..473025))
/gene="fba"
/locus_tag="BCG_0401c"
/note="intersubunit interface [polypeptide binding]; other
site"
/db_xref="CDD:238255"
misc_feature complement(order(472357..472359,472477..472479,
472609..472611,472630..472632,472720..472722,
472825..472827))
/gene="fba"
/locus_tag="BCG_0401c"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:238255"
misc_feature complement(order(472348..472350,472354..472356,
472468..472470,472474..472476,472480..472482))
/gene="fba"
/locus_tag="BCG_0401c"
/note="Na+ binding site [ion binding]; other site"
/db_xref="CDD:238255"
gene 473208..473891
/locus_tag="BCG_0402"
/db_xref="GeneID:4695684"
CDS 473208..473891
/locus_tag="BCG_0402"
/note="Differs from Rv0364 by 1aa, L193I"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976500.1"
/db_xref="GI:121636277"
/db_xref="GeneID:4695684"
/translation="MSTAVTAMPDILDPMYWLGANGVFGSAVLPGILIIVFIETGLLF
PLLPGESLLFTGGLLSASPAPPVTIGVLAPCVALVAVLGDQTAYFIGRRIGPALFKKE
DSRFFKKHYVTESHAFFEKYGKWTIILARFVPIARTFVPVIAGVSYMRYPVFLGFDIV
GGVAWGAGVTLAGYFLGSVPFVHMNFQLIILALVFVSLLPALVSAARVYRARRNAPQS
DPDPLVLPE"
misc_feature 473244..473846
/locus_tag="BCG_0402"
/note="Uncharacterized membrane-associated protein
[Function unknown]; Region: DedA; COG0586"
/db_xref="CDD:30931"
misc_feature <473376..473852
/locus_tag="BCG_0402"
/note="SNARE associated Golgi protein; Region:
SNARE_assoc; cl00429"
/db_xref="CDD:207043"
gene complement(473880..475010)
/locus_tag="BCG_0403c"
/db_xref="GeneID:4695525"
CDS complement(473880..475010)
/locus_tag="BCG_0403c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976501.1"
/db_xref="GI:121636278"
/db_xref="GeneID:4695525"
/translation="MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLF
GSWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLA
LALERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFL
ARYPDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLE
TELAVRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALV
ATTLPGDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGE
QARSVRGAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG"
misc_feature complement(473883..474998)
/locus_tag="BCG_0403c"
/note="Predicted glycosyl hydrolase [Carbohydrate
transport and metabolism]; Region: COG4833"
/db_xref="CDD:227170"
gene complement(475035..475628)
/locus_tag="BCG_0404c"
/db_xref="GeneID:4695589"
CDS complement(475035..475628)
/locus_tag="BCG_0404c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976502.1"
/db_xref="GI:121636279"
/db_xref="GeneID:4695589"
/translation="MKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWP
DDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSHPSKLELIRTARTAGYTVVLHVL
VIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA"
misc_feature complement(475068..475628)
/locus_tag="BCG_0404c"
/note="Uncharacterized protein conserved in bacteria
[Function unknown]; Region: COG4185"
/db_xref="CDD:226648"
misc_feature complement(475212..475613)
/locus_tag="BCG_0404c"
/note="AAA domain; Region: AAA_33; pfam13671"
/db_xref="CDD:222307"
gene complement(475657..476046)
/locus_tag="BCG_0405c"
/db_xref="GeneID:4698009"
CDS complement(475657..476046)
/locus_tag="BCG_0405c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976503.1"
/db_xref="GI:121636280"
/db_xref="GeneID:4698009"
/translation="MPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAV
SNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEISAAIEERLSRTNYGDVLAAQGI
TTVALNDAGDIVEHRPDGTSVVLAATP"
misc_feature complement(<475867..476031)
/locus_tag="BCG_0405c"
/note="Protein of unknown function (DUF3423); Region:
DUF3423; pfam11903"
/db_xref="CDD:152339"
gene complement(476127..477338)
/locus_tag="BCG_0406c"
/db_xref="GeneID:4695835"
CDS complement(476127..477338)
/locus_tag="BCG_0406c"
/note="Differs from Rv0368c by 1aa, H249R, and from
Mb0375c by 1aa, G371S"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976504.1"
/db_xref="GI:121636281"
/db_xref="GeneID:4695835"
/translation="MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQ
LVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRT
PVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPF
DQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLL
ARIRPRRRPRRVLLLCDVSRSMQPYAAIYLHLMRAAVLRRAGGHPEVFAFSTSLTRLT
SVLSHRSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDS
DPPDVLVHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGL
HQLLLALAGAR"
misc_feature complement(476184..476828)
/locus_tag="BCG_0406c"
/note="VWA domain containing CoxE-like protein; Region:
VWA_CoxE; pfam05762"
/db_xref="CDD:147747"
misc_feature complement(<476289..476636)
/locus_tag="BCG_0406c"
/note="von Willebrand factor (vWF) type A domain; Region:
VWA; smart00327"
/db_xref="CDD:214621"
misc_feature complement(order(476349..476351,476433..476435,
476634..476636))
/locus_tag="BCG_0406c"
/note="metal ion-dependent adhesion site (MIDAS); other
site"
/db_xref="CDD:238119"
gene complement(477344..477859)
/locus_tag="BCG_0407c"
/db_xref="GeneID:4695431"
CDS complement(477344..477859)
/locus_tag="BCG_0407c"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="membrane oxidoreductase"
/protein_id="YP_976505.1"
/db_xref="GI:121636282"
/db_xref="GeneID:4695431"
/translation="MPGAQLIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHR
AVFDAKGKEARGTGNAAATVAAQLHEVGERTRVTVDTDLKIVGKLAQFGSGMLQQVSE
KLLGQFVDSLEAELAAQSSESPQGTPPATEAAPIDLLQLADGGQLKKYGSALLAALTV
LLLIWVLRRRR"
misc_feature complement(477506..477859)
/locus_tag="BCG_0407c"
/note="Ligand-binding SRPBCC domain of an uncharacterized
subfamily of proteins; Region: SRPBCC_5; cd07823"
/db_xref="CDD:176865"
misc_feature complement(order(477524..477526,477533..477541,
477545..477553,477557..477571,477611..477613,
477617..477619,477623..477625,477629..477631,
477659..477661,477665..477667,477671..477676,
477719..477721,477725..477727,477755..477757,
477761..477763,477806..477808,477812..477814,
477818..477820,477824..477826,477848..477850))
/locus_tag="BCG_0407c"
/note="putative hydrophobic ligand binding site [chemical
binding]; other site"
/db_xref="CDD:176865"
gene complement(477960..478856)
/locus_tag="BCG_0408c"
/db_xref="GeneID:4697476"
CDS complement(477960..478856)
/locus_tag="BCG_0408c"
/EC_number="1.-.-.-"
/note="Differs from Rv0370c by 1aa, E201G"
/codon_start=1
/transl_table=11
/product="oxidoreductase"
/protein_id="YP_976506.1"
/db_xref="GI:121636283"
/db_xref="GeneID:4697476"
/translation="MTFASPDDVIRRFDEQNYLLDTGTASAIYLAVTLGRPLLLEGEP
GVGKTTAAKTLAVVLDTTLIRLQCYEGLTANEALYDWNYQRQLLSIRLAEARGKGISD
ISEADLYTEAYLVDRPILRCVRHRGPTPPVLLIDEIDRADDEFEALLLEFLGESAVTV
PELGTFLAECPPIAVLTSNRSRDLHDALRRRCLYHWIDYPEPDRAAAIVRRTVPGATA
PLIENATQFVCTARDLDLDKPPGVAETIDWVAALVALGVADLTAADSSPALASLGALA
KTPDDRTQIRDAYQAFTECSHA"
misc_feature complement(<478191..478856)
/locus_tag="BCG_0408c"
/note="MoxR-like ATPases [General function prediction
only]; Region: COG0714"
/db_xref="CDD:223786"
gene complement(478853..479446)
/locus_tag="BCG_0409c"
/db_xref="GeneID:4696983"
CDS complement(478853..479446)
/locus_tag="BCG_0409c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976507.1"
/db_xref="GI:121636284"
/db_xref="GeneID:4696983"
/translation="MTATQITGVVLAAGRSNRLGTPKQLLPYRDTTVLGATLDVARQA
GFDQLILTLGGAASAVRAAMALDGTDVVVVEDVERGCAASLRVALARVHPRATGIVLM
LGDQPQVAPATLRRIIDVGPATEIMVCRYADGVGHPFWFSRTVFGELARLHGDKGVWK
LVHSGRHPVRELAVDGCVPLDVDTWDDYRRLLESVPS"
misc_feature complement(478880..479431)
/locus_tag="BCG_0409c"
/note="GT_2_like_f is a subfamily of the
glycosyltransferase family 2 (GT-2) with unknown function;
Region: GT_2_like_f; cd04182"
/db_xref="CDD:133025"
misc_feature complement(order(479132..479134,479408..479410,
479414..479416))
/locus_tag="BCG_0409c"
/note="Ligand binding site; other site"
/db_xref="CDD:133025"
misc_feature complement(order(478898..478900,478904..478906,
479132..479134))
/locus_tag="BCG_0409c"
/note="metal-binding site"
/db_xref="CDD:133025"
gene complement(479443..480198)
/locus_tag="BCG_0410c"
/db_xref="GeneID:4695369"
CDS complement(479443..480198)
/locus_tag="BCG_0410c"
/note="Differs from Rv0372c by 1aa, G161S"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976508.1"
/db_xref="GI:121636285"
/db_xref="GeneID:4695369"
/translation="MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGT
IEGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGS
LEIFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASH
GGPEAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTP
AEIAVSIAAELIATLRGGGPRGRKALADENGGA"
misc_feature complement(479449..480198)
/locus_tag="BCG_0410c"
/note="Xanthine and CO dehydrogenases maturation factor,
XdhC/CoxF family [Posttranslational modification, protein
turnover, chaperones]; Region: XdhC; COG1975"
/db_xref="CDD:224886"
misc_feature complement(479971..480177)
/locus_tag="BCG_0410c"
/note="XdhC and CoxI family; Region: XdhC_CoxI; pfam02625"
/db_xref="CDD:202317"
misc_feature complement(479512..>479733)
/locus_tag="BCG_0410c"
/note="XdhC Rossmann domain; Region: XdhC_C; pfam13478"
/db_xref="CDD:222162"
gene complement(480217..482616)
/locus_tag="BCG_0411c"
/db_xref="GeneID:4696547"
CDS complement(480217..482616)
/locus_tag="BCG_0411c"
/EC_number="1.2.99.2"
/note="Differs from Rv0373c by 1aa, S122F"
/codon_start=1
/transl_table=11
/product="carbon monoxyde dehydrogenase large chain"
/protein_id="YP_976509.1"
/db_xref="GI:121636286"
/db_xref="GeneID:4696547"
/translation="MTTIESRPPSPEDLADNAQQPCGHGRMMRKEDPRFIRGRGTYVD
DVALPGMLHLAILRSPYAHARIVRIDVTAAQAHPKVKAVVTGADLAAKGLAWMPTLAN
DVQAVLATDKTRFQGQEVASVVAEDRYSARDACELVDVDYEPRDPVVDARTALDPSAP
VIRTDLEGKSDNHIFDWETGDAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVAD
LDPVTGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKVPIYPGYVC
AIVASLLLDKPVKWMEDRSENLTSTGFARDYIMVGEIAANRDGKILAIRSNVLADHGA
FNAQAAPAKYPAGFFGVFTGSYDIEAAYCHMTAVYTNKAPGGVAYACSFRITEAVYFV
ERLVDCLAFELKMDPAELRLRNLLRPNQFPYQSKTGWVYDSGDYETTMRKAMNMIGYE
ALRAEQKQRRARGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVL
RLSVQTQGQGHETTFAQIVAEELGIAPDDIEVVHGDTDQTPFGLGTYGSRSTPVSGGA
AALVARKVRDKAKIIASGMLEVSVADLQWEKGKFHVKGDPSAAVTIADIAMRAHGAGD
LPEGIEGGLDAEVCYNPSNLTYPYGAYFCVVDIDPGTAVVKVRRFLAVDDCGTRINPM
IIEGQVHGGIVDGIGMALMEMIAFDEDGNCLGGSLMDYLIPTALEVPHLETGHTVTPS
PHHPIGAKGIGESATVGSPPAVVNAVVDALAPFGVRHADMPLTPSRVWEAMQGRATPP
I"
misc_feature complement(480247..482526)
/locus_tag="BCG_0411c"
/note="carbon-monoxide dehydrogenase, large subunit;
Region: CO_dehy_Mo_lg; TIGR02416"
/db_xref="CDD:131469"
misc_feature complement(482179..482505)
/locus_tag="BCG_0411c"
/note="Aldehyde oxidase and xanthine dehydrogenase, a/b
hammerhead domain; Region: Ald_Xan_dh_C; pfam01315"
/db_xref="CDD:144787"
misc_feature complement(480430..482130)
/locus_tag="BCG_0411c"
/note="Molybdopterin-binding domain of aldehyde
dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738"
/db_xref="CDD:202368"
gene complement(482613..483092)
/locus_tag="BCG_0412c"
/db_xref="GeneID:4696006"
CDS complement(482613..483092)
/locus_tag="BCG_0412c"
/EC_number="1.2.99.2"
/codon_start=1
/transl_table=11
/product="carbon monoxyde dehydrogenase small chain"
/protein_id="YP_976510.1"
/db_xref="GI:121636287"
/db_xref="GeneID:4696006"
/translation="MQVNMTVNGEPVTAEVEPRMLLVHFLRDQLRLTGTHWGCDTSNC
GTCVVEVDGVPVKSCTMLAVMASGHSIRTVEGLAGPDGQLDPVQEGFMRCHGLQCGFC
TPGMLITARALLDRNPDPDEQTIREAISGQICRCTGYTTIVRSIQWAAAHQTVKAQS"
misc_feature complement(482634..483092)
/locus_tag="BCG_0412c"
/note="Aerobic-type carbon monoxide dehydrogenase, small
subunit CoxS/CutS homologs [Energy production and
conversion]; Region: CoxS; COG2080"
/db_xref="CDD:224991"
misc_feature complement(<482937..483086)
/locus_tag="BCG_0412c"
/note="2Fe-2S iron-sulfur cluster binding domain.
Iron-sulfur proteins play an important role in electron
transfer processes and in various enzymatic reactions. The
family includes plant and algal ferredoxins, which act as
electron carriers in photosynthesis...; Region: fer2;
cd00207"
/db_xref="CDD:238126"
misc_feature complement(order(482952..482963,482967..482969,
482976..482978,482985..482990))
/locus_tag="BCG_0412c"
/note="catalytic loop [active]"
/db_xref="CDD:238126"
misc_feature complement(order(482952..482954,482961..482963,
482976..482978))
/locus_tag="BCG_0412c"
/note="iron binding site [ion binding]; other site"
/db_xref="CDD:238126"
misc_feature complement(482652..482876)
/locus_tag="BCG_0412c"
/note="[2Fe-2S] binding domain; Region: Fer2_2; pfam01799"
/db_xref="CDD:201981"
gene complement(483107..483967)
/locus_tag="BCG_0413c"
/db_xref="GeneID:4696726"
CDS complement(483107..483967)
/locus_tag="BCG_0413c"
/EC_number="1.2.99.2"
/codon_start=1
/transl_table=11
/product="carbon monoxyde dehydrogenase medium chain"
/protein_id="YP_976511.1"
/db_xref="GI:121636288"
/db_xref="GeneID:4696726"
/translation="MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEYLVDINDL
APELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIFRDAERVIADPVVRNRG
TLGGSLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAIDDFLVGPYETALAHNEVLI
EVRIPLRHNTSSAYAKVERRVGDWAITAAGAAVTLDGQTILAARVGLTAVNPDPVALA
ELSAGLVGQPATEEVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGR
VLGAPAAPEA"
misc_feature complement(483140..483964)
/locus_tag="BCG_0413c"
/note="Aerobic-type carbon monoxide dehydrogenase, middle
subunit CoxM/CutM homologs [Energy production and
conversion]; Region: CoxM; COG1319"
/db_xref="CDD:224238"
misc_feature complement(483149..483454)
/locus_tag="BCG_0413c"
/note="CO dehydrogenase flavoprotein C-terminal domain;
Region: CO_deh_flav_C; pfam03450"
/db_xref="CDD:217566"
gene complement(484043..485185)
/locus_tag="BCG_0414c"
/db_xref="GeneID:4697103"
CDS complement(484043..485185)
/locus_tag="BCG_0414c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976512.1"
/db_xref="GI:121636289"
/db_xref="GeneID:4697103"
/translation="MAIWAAGDTAGVATVVRTLRSAPRPPGAAMVVAPDGSVSGSVSG
GCVEGAVYELAAEVAQTGIPRLEHYGVSDDTAFAVGLTCGGIIDVFVEPVSRATFPEL
GELADDIGAQRPVAIATVIAHPDERRVGRRLVIRPDTKSPVTGSLGSARADAAVIDDA
RGLLAVGRSEILEYGPDGQRRGEGMEVFVSSHAPRPRMLVFGAIDFAAALARQGSFLG
YRVTVCDARAVFATPARFPTADDVVVAWPHRYLAAQAEAGGIDERTVICVLTHDPKFD
VPVLEVALRLGVGYVGAMGSRKTHDDRMDRLRAAGLTDAELSRLSSPIGLDLGARTPE
ETAVSIAADIIARRWGGGGRPLADIAGRIHHDAQVAGEFKDYLTRH"
misc_feature complement(484976..>485137)
/locus_tag="BCG_0414c"
/note="XdhC and CoxI family; Region: XdhC_CoxI; pfam02625"
/db_xref="CDD:202317"
misc_feature complement(484079..484876)
/locus_tag="BCG_0414c"
/note="Xanthine and CO dehydrogenases maturation factor,
XdhC/CoxF family [Posttranslational modification, protein
turnover, chaperones]; Region: XdhC; COG1975"
/db_xref="CDD:224886"
misc_feature complement(484658..484870)
/locus_tag="BCG_0414c"
/note="XdhC and CoxI family; Region: XdhC_CoxI; pfam02625"
/db_xref="CDD:202317"
misc_feature complement(484154..484594)
/locus_tag="BCG_0414c"
/note="XdhC Rossmann domain; Region: XdhC_C; pfam13478"
/db_xref="CDD:222162"
gene 485234..486199
/locus_tag="BCG_0415"
/db_xref="GeneID:4696588"
CDS 485234..486199
/locus_tag="BCG_0415"
/note="Differs from Rv0377 by 1aa, R302P"
/codon_start=1
/transl_table=11
/product="LysR family transcriptional regulator"
/protein_id="YP_976513.1"
/db_xref="GI:121636290"
/db_xref="GeneID:4696588"
/translation="MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMHVAALRKELD
DPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTAIEVTEAAHGRRLLRIAASSAFAE
HAAPGLIELFSSRADDLSVELSVHPTSRFRELICSRAVDIAIGPASESSIGSDGSIFL
RPFLKYQIITVVAPNSPLAAGIPMPALLRHQQWMLGPSAGSVDGEIATMLRGLAIPES
QQRIFQSDAAALEEVMRVGGATLAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLA
PSARQPAVSELVGFISTPRCIQAMIRGSGVGVTRFRPKVHVTLWS"
misc_feature 485234..486106
/locus_tag="BCG_0415"
/note="Transcriptional regulator [Transcription]; Region:
LysR; COG0583"
/db_xref="CDD:223656"
misc_feature 485246..485416
/locus_tag="BCG_0415"
/note="Bacterial regulatory helix-turn-helix protein, lysR
family; Region: HTH_1; pfam00126"
/db_xref="CDD:215735"
misc_feature 485498..486106
/locus_tag="BCG_0415"
/note="LysR substrate binding domain; Region:
LysR_substrate; pfam03466"
/db_xref="CDD:217576"
misc_feature order(485549..485554,485558..485563,485570..485572,
485582..485584,485588..485608,485900..485908,
485924..485929,485933..485938)
/locus_tag="BCG_0415"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:176102"
gene 486450..486671
/locus_tag="BCG_0416"
/db_xref="GeneID:4697455"
CDS 486450..486671
/locus_tag="BCG_0416"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976514.1"
/db_xref="GI:121636291"
/db_xref="GeneID:4697455"
/translation="MSGRWEAGNADGNGGSAGLIGSGGAGGDGGSGGATGAGGEGGDA
GASGSINGNAGDPGNSGERGAVGKPGAPG"
gene 486790..487005
/gene="secE2"
/locus_tag="BCG_0417"
/db_xref="GeneID:4697673"
CDS 486790..487005
/gene="secE2"
/locus_tag="BCG_0417"
/codon_start=1
/transl_table=11
/product="protein transport protein secE2"
/protein_id="YP_976515.1"
/db_xref="GI:121636292"
/db_xref="GeneID:4697673"
/translation="MSVYKVIDIIGTSPTSWEQAAAEAVQRARDSVDDIRVARVIEQD
MAVDSAGKITYRIKLEVSFKMRPAQPR"
misc_feature 486790..486996
/gene="secE2"
/locus_tag="BCG_0417"
/note="Uncharacterized conserved protein [Function
unknown]; Region: COG3360"
/db_xref="CDD:225896"
gene complement(487081..487632)
/locus_tag="BCG_0418c"
/db_xref="GeneID:4697708"
CDS complement(487081..487632)
/locus_tag="BCG_0418c"
/EC_number="2.1.1.-"
/codon_start=1
/transl_table=11
/product="rna methyltransferase"
/protein_id="YP_976516.1"
/db_xref="GI:121636293"
/db_xref="GeneID:4697708"
/translation="MLLRDGDARNVVDAYRYWTREAIIADIDTRRHPLHVAIENFGHD
ANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTTGLLEFAAGAGL
TVVAVDNVPGAARLEQTALPRECLLLFGQEGPGITDDARAGAAVTVSIAQFGSTRSIN
AGVAAGIAMHAWIRQHADLGRAW"
misc_feature complement(487096..>487614)
/locus_tag="BCG_0418c"
/note="rRNA methylases [Translation, ribosomal structure
and biogenesis]; Region: SpoU; COG0566"
/db_xref="CDD:223640"
misc_feature complement(487123..487536)
/locus_tag="BCG_0418c"
/note="SpoU rRNA Methylase family; Region: SpoU_methylase;
pfam00588"
/db_xref="CDD:216010"
gene complement(487728..488636)
/locus_tag="BCG_0419c"
/db_xref="GeneID:4697216"
CDS complement(487728..488636)
/locus_tag="BCG_0419c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976517.1"
/db_xref="GI:121636294"
/db_xref="GeneID:4697216"
/translation="MRILVAWATCGAVVLSGLTGCSGSSHSGRTYGAQSARTGESLAV
LGWNMSVSNLRWSGDYVLIDVDASPTDPHAPHAKPEDIRFGLYGALAHPMESAALGSC
GDAMAHVRDVVSPLSAPAGRLTGTVCLGPLKERSAVRGVYTYSPRDRIPGTAAAYPAA
FPVGMLPTNQNDAGLVVKTTSVSAWRADGMQLGKPQLGDPVAFTGNGYMLLGLEVDAV
PDRYRDDSAARGGPMMLLAAPTLPGRGLSPACATYGSSVLILPDALLDAVHISASLCT
QGEINEALLYATVATVGTHAALWTSR"
gene complement(488654..489193)
/gene="pyrE"
/locus_tag="BCG_0420c"
/db_xref="GeneID:4697528"
CDS complement(488654..489193)
/gene="pyrE"
/locus_tag="BCG_0420c"
/EC_number="2.4.2.10"
/note="involved in fifth step of pyrimidine biosynthesis;
converts orotidine 5'-phosphate and diphosphate to orotate
and 5-phospho-alpha-D-ribose 1-diphosphate"
/codon_start=1
/transl_table=11
/product="orotate phosphoribosyltransferase"
/protein_id="YP_976518.1"
/db_xref="GI:121636295"
/db_xref="GeneID:4697528"
/translation="MAGPDRAELAELVRRLSVVHGRVTLSSGREADYYVDLRRATLHH
RASALIGRLMRELTADWDYSVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKAHGM
QRLIEGSEVTGQRVLVVEDTSTTGNSALTAVHAVQDVGGEVVGVATVVDRATGAAEAI
EAEGLRYRSVLGLADLGLD"
misc_feature complement(<488783..489049)
/gene="pyrE"
/locus_tag="BCG_0420c"
/note="Phosphoribosyl transferase (PRT)-type I domain;
Region: PRTases_typeI; cd06223"
/db_xref="CDD:206754"
misc_feature complement(order(488810..488824,488828..488836,
488978..488980,488984..488986))
/gene="pyrE"
/locus_tag="BCG_0420c"
/note="active site"
/db_xref="CDD:206754"
gene complement(489274..490128)
/locus_tag="BCG_0421c"
/db_xref="GeneID:4697784"
CDS complement(489274..490128)
/locus_tag="BCG_0421c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976519.1"
/db_xref="GI:121636296"
/db_xref="GeneID:4697784"
/translation="MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFD
YERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGT
NVVVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAE
IMWNEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAA
PGRPVAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNG
QQATNYQH"
gene complement(490269..492815)
/gene="clpB"
/locus_tag="BCG_0422c"
/db_xref="GeneID:4697361"
CDS complement(490269..492815)
/gene="clpB"
/locus_tag="BCG_0422c"
/EC_number="3.-.-.-"
/standard_name="htpM"
/codon_start=1
/transl_table=11
/product="endopeptidase ATP binding protein subunit B"
/protein_id="YP_976520.1"
/db_xref="GI:121636297"
/db_xref="GeneID:4697361"
/translation="MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDG
IAAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQPQLSRESLAAITTAQQLATELD
DEYVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQA
LQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEG
LAQRIVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITF
IDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEYRKHIEKDAALERRF
QQVYVGEPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAI
DLVDEAASRLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELA
DQKEKLAELTTRWQNEKNAIEIVRDLKEQLEALRGESERAERDGDLAKAAELRYGRIP
EVEKKLDAALPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMED
ELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFL
FDDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIE
KAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTSNLGSGGSAEQVLAAVRATFK
PEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGF
DPVYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG"
misc_feature complement(490293..492743)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="ATP-dependent chaperone ClpB; Region:
chaperone_ClpB; TIGR03346"
/db_xref="CDD:234173"
misc_feature complement(492609..492743)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="Clp amino terminal domain; Region: Clp_N;
pfam02861"
/db_xref="CDD:217254"
misc_feature complement(492381..492518)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="Clp amino terminal domain; Region: Clp_N;
pfam02861"
/db_xref="CDD:217254"
misc_feature complement(491805..492275)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature complement(492177..492200)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature complement(order(491868..491870,491982..491984,
492174..492197))
/gene="clpB"
/locus_tag="BCG_0422c"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature complement(491979..491996)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature complement(491817..491819)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="arginine finger; other site"
/db_xref="CDD:99707"
misc_feature complement(490554..491099)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature complement(490974..490997)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature complement(order(490653..490655,490779..490781,
490971..490994))
/gene="clpB"
/locus_tag="BCG_0422c"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature complement(490776..490793)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature complement(490578..490580)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="arginine finger; other site"
/db_xref="CDD:99707"
misc_feature complement(490308..490550)
/gene="clpB"
/locus_tag="BCG_0422c"
/note="C-terminal, D2-small domain, of ClpB protein;
Region: ClpB_D2-small; pfam10431"
/db_xref="CDD:204486"
gene 492948..494120
/locus_tag="BCG_0423"
/db_xref="GeneID:4697010"
CDS 492948..494120
/locus_tag="BCG_0423"
/EC_number="1.-.-.-"
/codon_start=1
/transl_table=11
/product="monooxygenase"
/protein_id="YP_976521.1"
/db_xref="GI:121636298"
/db_xref="GeneID:4697010"
/translation="MGLEDRDALRVLQNAFKLDDPELVRRFYAHWFALDASVRDLFPP
DMGAQRAAFGQALHWVYGELVAQRAEEPVAFLAQLGRDHRKYGVLPTQYDTLRRALYT
TLRDYLGHPSRGAWTDAVDEAAGQSLNLIIGVMSGAADADDAPAWWDGTVVEHIRVSR
DLAVARLQLDRPLHYYPGQYVNVHVPQCPRRWRYLSPAIPADPNGRIEFHVRVVPGGL
VSNAIVGETRPGDRWRLSGPHGAFRVDRDGGDVLMVAGSTGLAPLRALIIDLSRFAVN
PRVHLFFGARYACELYDLPTLWQIAAHNPWLSVSPVSEYNGDPAWAADYPDVSAPRGL
HVRQTGRLPDVVSRYGGWGDRQILICGGPAMVRATKAALIAKGAPPERIQHDPLSR"
misc_feature 492957..493352
/locus_tag="BCG_0423"
/note="Globins are heme proteins, which bind and transport
oxygen. This family summarizes a diverse set of homologous
protein domains, including: (1) tetrameric vertebrate
hemoglobins, which are the major protein component of
erythrocytes and transport oxygen...; Region: globin;
cd01040"
/db_xref="CDD:238510"
misc_feature 493008..494096
/locus_tag="BCG_0423"
/note="bifunctional nitric oxide
dioxygenase/dihydropteridine reductase 2; Provisional;
Region: PRK13289"
/db_xref="CDD:237337"
misc_feature order(493029..493031,493059..493061,493068..493073,
493092..493094,493101..493103,493191..493196,
493224..493226,493233..493235,493338..493340)
/locus_tag="BCG_0423"
/note="heme-binding site [chemical binding]; other site"
/db_xref="CDD:238510"
misc_feature 493401..494108
/locus_tag="BCG_0423"
/note="The oxygenase reductase FAD/NADH binding domain
acts as part of the multi-component bacterial oxygenases
which oxidize hydrocarbons using oxygen as the oxidant.
Electron transfer is from NADH via FAD (in the oxygenase
reductase) and an [2FE-2S]...; Region:
O2ase_reductase_like; cd06187"
/db_xref="CDD:99784"
misc_feature order(493485..493487,493524..493535,493575..493583,
493587..493589,493599..493607,493719..493721,
493728..493730,494103..494105)
/locus_tag="BCG_0423"
/note="FAD binding pocket [chemical binding]; other site"
/db_xref="CDD:99784"
misc_feature order(493524..493526,493530..493535)
/locus_tag="BCG_0423"
/note="FAD binding motif [chemical binding]; other site"
/db_xref="CDD:99784"
misc_feature order(493596..493598,493605..493607,493614..493616,
493635..493637,493659..493661,493665..493667)
/locus_tag="BCG_0423"
/note="phosphate binding motif [ion binding]; other site"
/db_xref="CDD:99784"
misc_feature order(493704..493706,493716..493727,493731..493733)
/locus_tag="BCG_0423"
/note="beta-alpha-beta structure motif; other site"
/db_xref="CDD:99784"
misc_feature order(493719..493724,493797..493805,494028..494033)
/locus_tag="BCG_0423"
/note="NAD binding pocket [chemical binding]; other site"
/db_xref="CDD:99784"
gene 494224..497481
/locus_tag="BCG_0424"
/db_xref="GeneID:4697702"
CDS 494224..497481
/locus_tag="BCG_0424"
/note="Differs from Mb0393 by 1aa, D902A"
/codon_start=1
/transl_table=11
/product="LuxR family transcriptional regulator"
/protein_id="YP_976522.1"
/db_xref="GI:121636299"
/db_xref="GeneID:4697702"
/translation="MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSG
VIAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALR
DEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSR
PERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVT
LTGAGGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRS
TTDTVLRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEV
SYRVPSLSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAAR
LRSMTLDEIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAV
FVGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYA
LEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNR
ENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADK
ALLDIFVDAAAGMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAE
AIDLARAVDDRWRLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCR
WCLGYAQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARA
AADAALEAAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQ
RAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAH
KALACAAESGAHLDLPDVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYR
SDYVQSVTALRDAMGEKDFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPT
EIDVVRLVGEGLANKDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT"
misc_feature 494248..494754
/locus_tag="BCG_0424"
/note="Adenylate cyclase, family 3 (some proteins contain
HAMP domain) [Signal transduction mechanisms]; Region:
CyaA; COG2114"
/db_xref="CDD:225025"
misc_feature 494248..494724
/locus_tag="BCG_0424"
/note="cyclase homology domain; Region: CHD; cd07302"
/db_xref="CDD:143636"
misc_feature order(494263..494265,494269..494286,494392..494394,
494398..494406,494413..494415,494539..494547,
494557..494562,494569..494574,494689..494691)
/locus_tag="BCG_0424"
/note="nucleotidyl binding site; other site"
/db_xref="CDD:143636"
misc_feature order(494269..494271,494404..494406)
/locus_tag="BCG_0424"
/note="metal binding site [ion binding]; metal-binding
site"
/db_xref="CDD:143636"
misc_feature order(494284..494286,494317..494319,494326..494331,
494338..494340,494350..494352,494392..494397,
494542..494553,494560..494562,494689..494691)
/locus_tag="BCG_0424"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:143636"
misc_feature 494827..496041
/locus_tag="BCG_0424"
/note="Predicted ATPase [General function prediction
only]; Region: COG3903"
/db_xref="CDD:226418"
misc_feature 494869..>495111
/locus_tag="BCG_0424"
/note="RecA-like NTPases. This family includes the NTP
binding domain of F1 and V1 H+ATPases, DnaB and related
helicases as well as bacterial RecA and related eukaryotic
and archaeal recombinases. This group also includes
bacterial conjugation proteins and...; Region:
RecA-like_NTPases; cl17233"
/db_xref="CDD:247787"
misc_feature order(494884..494889,494899..494907)
/locus_tag="BCG_0424"
/note="Walker A motif; other site"
/db_xref="CDD:238540"
misc_feature order(494887..494889,494899..494907,494962..494964,
494968..494973,495106..495111)
/locus_tag="BCG_0424"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:238540"
misc_feature 495094..495108
/locus_tag="BCG_0424"
/note="Walker B motif; other site"
/db_xref="CDD:238540"
misc_feature <497158..497433
/locus_tag="BCG_0424"
/note="Response regulator containing a CheY-like receiver
domain and an HTH DNA-binding domain [Signal transduction
mechanisms / Transcription]; Region: CitB; COG2197"
/db_xref="CDD:225107"
misc_feature 497302..497442
/locus_tag="BCG_0424"
/note="C-terminal DNA-binding domain of LuxR-like
proteins. This domain contains a helix-turn-helix motif
and binds DNA. Proteins belonging to this group are
response regulators; some act as transcriptional
activators, others as transcriptional repressors. Many...;
Region: LuxR_C_like; cd06170"
/db_xref="CDD:99777"
misc_feature order(497305..497313,497350..497358,497380..497385,
497389..497394,497398..497412)
/locus_tag="BCG_0424"
/note="DNA binding residues [nucleotide binding]"
/db_xref="CDD:99777"
gene complement(497485..498816)
/gene="PPE9"
/locus_tag="BCG_0425c"
/db_xref="GeneID:4696958"
CDS complement(497485..498816)
/gene="PPE9"
/locus_tag="BCG_0425c"
/note="In Mycobacterium tuberculosis strain H37Rv, Rv0388c
and Rv0387c exist as 2 separate genes. In Mycobacterium
bovis BCG Pasteur, and Mycobacterium bovis, 3 different
base substitutions, the first of 14 bases, the second of 8
bases (tctacagt-gctacagg), and lastly of 28 bases, leads
to a longer single product;
Differs from Mb0394c by 1aa, T361A"
/codon_start=1
/transl_table=11
/product="PPE family protein"
/protein_id="YP_976523.1"
/db_xref="GI:121636300"
/db_xref="GeneID:4696958"
/translation="MDFGALPPEINSARIYSGPGSRPLMQAAAAWQRLANELTATAAS
YSSVISGLTGDDWLGPSALSMAAAAVPYVAWMRATAASAEQAAAQAVAAANAYESAYA
ATVPPTVIAANRRTMLSLVKTNVFGQNTPAIATSEAQYGAMWAQDIVAMEGYAGASAA
ASQLPPFTPPPATTSGAGSLSDAAATAAQAVVPAAAATDVSLLPTLQSFLPPPFDAIP
NPIEDLDVLVAAAVAVAAGSLGVSAAQLGEIYRHDVVDEAQKAPHCPAESDQTPAGAA
GDGDLPEVGGRVTSPPQPPVAALTGYSANIGGLSVPHSWNLPPAVRQVAAMFPGATPM
YMTGSSDGSYAGLAAAGLAGTGLAGLTARGGSAPTPAAAAPAGAGGAGPAATRPAAQQ
TPAVPAAAAGSAIPGLPPGLPPGVVANLAATLAAIPGATIIVVPPSPNANQ"
misc_feature complement(<498304..498816)
/gene="PPE9"
/locus_tag="BCG_0425c"
/note="PPE-repeat proteins [Cell motility and secretion];
Region: COG5651"
/db_xref="CDD:35210"
misc_feature complement(498361..498804)
/gene="PPE9"
/locus_tag="BCG_0425c"
/note="PPE family; Region: PPE; pfam00823"
/db_xref="CDD:189731"
gene 499150..500409
/gene="purT"
/locus_tag="BCG_0426"
/db_xref="GeneID:4696418"
CDS 499150..500409
/gene="purT"
/locus_tag="BCG_0426"
/EC_number="2.1.2.-"
/note="non-folate utilizing enzyme, catalyzes the
production of beta-formyl glycinamide ribonucleotide from
formate, ATP, and beta-GAR and a side reaction producing
acetyl phosphate and ADP from acetate and ATP; involved in
de novo purine biosynthesis"
/codon_start=1
/transl_table=11
/product="phosphoribosylglycinamide formyltransferase 2"
/protein_id="YP_976524.1"
/db_xref="GI:121636301"
/db_xref="GeneID:4696418"
/translation="MIDGWTEGQHEPTVRHERPAAPQDVRRVMLLGSAEPSRELAIAL
QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVD
ALDAVEQADGECTELVPNARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLGELQAV
AVHAGFPLLVSPVAGVAGQGSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESV
VEIEFLVTMIVVCSQGPNGPLIEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIA
ARIVKALGGRGVFGVELMINGDEVYFADVTVCPAGSAWVTVRSQRLSVFELQARATLG
LAVDTLMISPGAARVINPDHTAGRAAVGAAPPADALTGALGVPESDVVIFGRGLGVAL
ATAPEVAIARERAREVASRLNVPDSRE"
misc_feature 499228..500394
/gene="purT"
/locus_tag="BCG_0426"
/note="phosphoribosylglycinamide formyltransferase 2;
Region: purT; TIGR01142"
/db_xref="CDD:130212"
misc_feature 499561..500028
/gene="purT"
/locus_tag="BCG_0426"
/note="ATP-grasp domain; Region: ATP-grasp_4; cl03087"
/db_xref="CDD:207834"
gene 500406..500828
/locus_tag="BCG_0427"
/db_xref="GeneID:4696059"
CDS 500406..500828
/locus_tag="BCG_0427"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976525.1"
/db_xref="GI:121636302"
/db_xref="GeneID:4696059"
/translation="MSYAGDITPLQAWEMLSDNPRAVLVDVRCEAEWRFVGVPDLSSL
GREVVYVEWATSDGTHNDNFLAELRDRIPADADQHERPVIFLCRSGNRSIGAAEVATE
AGITPAYNVLDGFEGHLDAEGHRGATGWRAVGLPWRQG"
misc_feature 500424..500801
/locus_tag="BCG_0427"
/note="Member of the Rhodanese Homology Domain
superfamily, subgroup 1. This CD includes the putative
rhodanese-related sulfurtransferases of several
uncharacterized proteins; Region: RHOD_1; cd01522"
/db_xref="CDD:238780"
misc_feature 500664..500666
/locus_tag="BCG_0427"
/note="active site residue [active]"
/db_xref="CDD:238780"
gene 500825..502045
/gene="metZ"
/locus_tag="BCG_0428"
/db_xref="GeneID:4696910"
CDS 500825..502045
/gene="metZ"
/locus_tag="BCG_0428"
/EC_number="4.2.99.-"
/codon_start=1
/transl_table=11
/product="O-succinylhomoserine sulfhydrylase"
/protein_id="YP_976526.1"
/db_xref="GI:121636303"
/db_xref="GeneID:4696910"
/translation="MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTS
GYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVF
TSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQ
AVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGT
KHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHS
NASAQRIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQ
RAFEVLDKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLE
DTDDLIADIDRALS"
misc_feature 500834..502042
/gene="metZ"
/locus_tag="BCG_0428"
/note="O-succinylhomoserine sulfhydrylase; Provisional;
Region: PRK07810"
/db_xref="CDD:236103"
misc_feature 500945..502042
/gene="metZ"
/locus_tag="BCG_0428"
/note="CGS_like: Cystathionine gamma-synthase is a PLP
dependent enzyme and catalyzes the committed step of
methionine biosynthesis. This pathway is unique to
microorganisms and plants, rendering the enzyme an
attractive target for the development of...; Region:
CGS_like; cd00614"
/db_xref="CDD:99738"
misc_feature order(500948..500959,500963..500968,501023..501025,
501029..501031,501107..501112,501116..501121,
501188..501190,501203..501205,501212..501214,
501476..501478,501500..501502,501506..501508,
501557..501559,501587..501589,501593..501598,
501845..501847)
/gene="metZ"
/locus_tag="BCG_0428"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:99738"
misc_feature order(501110..501118,501188..501190,501317..501319,
501404..501406,501470..501472,501476..501481,
501506..501508)
/gene="metZ"
/locus_tag="BCG_0428"
/note="substrate-cofactor binding pocket; other site"
/db_xref="CDD:99738"
misc_feature order(501110..501118,501188..501190,501404..501406,
501413..501415,501470..501472,501476..501481)
/gene="metZ"
/locus_tag="BCG_0428"
/note="pyridoxal 5'-phosphate binding site [chemical
binding]; other site"
/db_xref="CDD:99738"
misc_feature 501479..501481
/gene="metZ"
/locus_tag="BCG_0428"
/note="catalytic residue [active]"
/db_xref="CDD:99738"
gene complement(502042..503454)
/gene="ndhA"
/locus_tag="BCG_0429c"
/db_xref="GeneID:4699106"
CDS complement(502042..503454)
/gene="ndhA"
/locus_tag="BCG_0429c"
/EC_number="1.6.99.3"
/note="Differs from Rv0392c by 1aa, A241V"
/codon_start=1
/transl_table=11
/product="membrane NADH dehydrogenase ndhA"
/protein_id="YP_976527.1"
/db_xref="GI:121636304"
/db_xref="GeneID:4699106"
/translation="MTLSSGEPSAVGGRHRVVIIGSGFGGLNAAKALKRADVDITLIS
KTTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGEVNAIDLKAQTVTSK
LMDMTTVTPYDSLIVAAGAQQSYFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEV
STDHAERERRLTFVVVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAP
AVLPPMGPKLGLKAQRRLEKMDAEVQLNAMVTAVDYKGITIKEKDGGERRIECACKVW
AAGVAASPLGKMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVGDLMFVPGVPGVA
QGAIQGARYATTVIKHMVKGNDDPANRKPFHYFNKGSMATISRHSAVAQVGKLEFAGY
FAWLAWLVLHLVYLVGYRNRIAALFAWGISFMGRARGQMAITSQMIYARLVMTLMEQQ
AQGALAAAEQAEHAEQEAAG"
misc_feature complement(502165..503415)
/gene="ndhA"
/locus_tag="BCG_0429c"
/note="NADH dehydrogenase, FAD-containing subunit [Energy
production and conversion]; Region: Ndh; COG1252"
/db_xref="CDD:31444"
misc_feature complement(<503320..503400)
/gene="ndhA"
/locus_tag="BCG_0429c"
/note="Rossmann-fold NAD(P)(+)-binding proteins; Region:
NADB_Rossmann; cl09931"
/db_xref="CDD:214164"
misc_feature complement(502663..502935)
/gene="ndhA"
/locus_tag="BCG_0429c"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox; pfam00070"
/db_xref="CDD:200974"
gene 503596..504921
/locus_tag="BCG_0430"
/db_xref="GeneID:4696138"
CDS 503596..504921
/locus_tag="BCG_0430"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976528.1"
/db_xref="GI:121636305"
/db_xref="GeneID:4696138"
/translation="MAVGRCAIPRFDQAASGSAINGGQVHLSDGSTSPARQLPAPWPG
DAGAAAEGRAGVCCRGNRLPHVSDVGVSHRFDHRPAGVGAGGCRAGAAGAGLAVDDPG
QLAAAIDRIVAVADPDAVRQVRERARDREVSIWNSADGMGEVYAQLYATDAQALDARL
NALVATVCAGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVSAVVIHVVA
EQASVKGHGQAPAALLGGDGLIPAELVAELAKTAGLQPIPVPAGTEPGYRPSVKLAAF
VRARDLTCRAPGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCGWRAQ
QLPDGTVIWTLPGNQTYVTTPGSALLFPALCTPTGDPPAPEPARADRRGQRTAMMPRR
ASTRTQNRAHCIAAERHRNHQARRIAQAAVIATETHGPPPDPDDDPPPF"
misc_feature <503962..504438
/locus_tag="BCG_0430"
/note="Domain of unknown function (DUF222); Region:
DUF222; pfam02720"
/db_xref="CDD:217200"
misc_feature 504409..504576
/locus_tag="BCG_0430"
/note="HNH nucleases; HNH endonuclease signature which is
found in viral, prokaryotic, and eukaryotic proteins. The
alignment includes members of the large group of homing
endonucleases, yeast intron 1 protein, MutS, as well as
bacterial colicins, pyocins, and...; Region: HNHc;
cd00085"
/db_xref="CDD:238038"
misc_feature order(504484..504486,504490..504498,504502..504504,
504535..504540,504550..504555,504562..504564,
504574..504576)
/locus_tag="BCG_0430"
/note="active site"
/db_xref="CDD:238038"
gene complement(504937..505656)
/locus_tag="BCG_0431c"
/db_xref="GeneID:4697365"
CDS complement(504937..505656)
/locus_tag="BCG_0431c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976529.1"
/db_xref="GI:121636306"
/db_xref="GeneID:4697365"
/translation="MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETT
TREICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDD
QKVEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVL
AALIQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLI
LPSGGSAPTGDHPTPHPSTSR"
gene 505755..506159
/locus_tag="BCG_0432"
/db_xref="GeneID:4696421"
CDS 505755..506159
/locus_tag="BCG_0432"
/note="Differs from Rv0395 by 1aa, A80V"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976530.1"
/db_xref="GI:121636307"
/db_xref="GeneID:4696421"
/translation="MDWMPLGDYETFRHWSGKPRAWGPQESGWRAWFGGKIVDGLCEV
LDEHLAVRRRGVPAAIGCVPWLSSEAVAETLLALSAFCVVIDKGTSFPSRLRNPDKGF
PNVALLRLRDMAPSEHGSRCSSARGRLCLSMS"
gene 506165..506557
/locus_tag="BCG_0433"
/db_xref="GeneID:4696027"
CDS 506165..506557
/locus_tag="BCG_0433"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976531.1"
/db_xref="GI:121636308"
/db_xref="GeneID:4696027"
/translation="MRALGWLREDRKPLLNAKLLVLGHLALNVYDPDNGYGEEVLDFE
PRTVWWGSANWTVRAGSHLEVGFACDDPTLVEEATAFVADVIAFSEPIDTTCAGPEPN
LVQVEFDDAAMAEAMEEMAEPDDDGEDW"
misc_feature <506291..506404
/locus_tag="BCG_0433"
/note="PLD-like domain; Region: PLDc_2; pfam13091"
/db_xref="CDD:221916"
gene 506631..506999
/locus_tag="BCG_0434"
/db_xref="GeneID:4695980"
CDS 506631..506999
/locus_tag="BCG_0434"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976532.1"
/db_xref="GI:121636309"
/db_xref="GeneID:4695980"
/translation="MLATFWGWRAQQLPDGTVIWTLPGDQTYVTTPGSALLFPALCTP
TGDPPRPDPARADRRGQRTAMMPRRASTRAQNRAHYIAAERHRNHQARRIAHVVTQTA
TTAPETNGPPPDPDDDPPPF"
gene complement(507494..508135)
/locus_tag="BCG_0435c"
/db_xref="GeneID:4697139"
CDS complement(507494..508135)
/locus_tag="BCG_0435c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976533.1"
/db_xref="GI:121636310"
/db_xref="GeneID:4697139"
/translation="MGVIARVVGVAACGLSLAVLAAAPTAGAEPTGALPPMTSSGSGP
VIGDGDAALRQRISQQLFSFGDPTVQEVDGSDAAQFITAAAAVADRDVASVFLPLQRV
LGCQQNTAGSGAGFGARAYRRTDGQWGGAMLVVAKSTVSDVDALKACVKSGWRKATAG
TPTSMCNNGWTYPPFADTRRGEEGYFVLLAGTASDFCSAPNANYRTTASSWPG"
gene complement(508142..509371)
/gene="lpqK"
/locus_tag="BCG_0436c"
/db_xref="GeneID:4695965"
CDS complement(508142..509371)
/gene="lpqK"
/locus_tag="BCG_0436c"
/codon_start=1
/transl_table=11
/product="lipoprotein lpqK"
/protein_id="YP_976534.1"
/db_xref="GI:121636311"
/db_xref="GeneID:4695965"
/translation="MPVLRRLGCSVLALGLLAGCAPPRTGPASSPTNNGAKADAVIRI
VRDFMTQAHLKAVLVRVTVAGKEVVTRAVGDSMTGVPATTAMHFRNGAVAISYVATLL
LKLVDEKKLRLDDKLSRWLPDFPHADRVTLGQLAQMTSGYPDYVLGNEAFDAELYANP
FRQWTTQELLDQISSRPLLYDPGTNWNYAHTNYLLLGLALEKAAGQDMPTLLQRKVLS
PLGLTATANSDTPAIPEPALHAFTSERRAALKIPAGVPFYEESTFWNPSWTITHGAIQ
TTTIYDMEATAVGIGSGRLLSADSYKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLG
IVISGHWLLQNPMFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQGNYRNQADILFRK
IGAEVAPNDAPPMPPGR"
misc_feature complement(508175..509290)
/gene="lpqK"
/locus_tag="BCG_0436c"
/note="Beta-lactamase class C and other penicillin binding
proteins [Defense mechanisms]; Region: AmpC; COG1680"
/db_xref="CDD:224594"
misc_feature complement(508202..509251)
/gene="lpqK"
/locus_tag="BCG_0436c"
/note="Beta-lactamase; Region: Beta-lactamase; pfam00144"
/db_xref="CDD:215746"
gene complement(509381..510568)
/gene="fadE7"
/locus_tag="BCG_0437c"
/db_xref="GeneID:4698158"
CDS complement(509381..510568)
/gene="fadE7"
/locus_tag="BCG_0437c"
/EC_number="1.3.99.-"
/codon_start=1
/transl_table=11
/product="acyl-CoA dehydrogenase fadE7"
/protein_id="YP_976535.1"
/db_xref="GI:121636312"
/db_xref="GeneID:4698158"
/translation="MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHV
AAWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRS
LVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARR
DGPDWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRA
SITSELVLDNVRLPADAMLPGATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYA
RQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNN
TREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLA
AFR"
misc_feature complement(509387..510544)
/gene="fadE7"
/locus_tag="BCG_0437c"
/note="Glutaryl-CoA dehydrogenase; Region: GCD; cd01151"
/db_xref="CDD:173840"
misc_feature complement(509384..510520)
/gene="fadE7"
/locus_tag="BCG_0437c"
/note="Acyl-CoA dehydrogenases [Lipid metabolism]; Region:
CaiA; COG1960"
/db_xref="CDD:224871"
misc_feature complement(order(509435..509437,509441..509443,
509462..509464,510044..510046,510050..510052,
510122..510127,510140..510145,510149..510151))
/gene="fadE7"
/locus_tag="BCG_0437c"
/note="FAD binding site [chemical binding]; other site"
/db_xref="CDD:173840"
misc_feature complement(order(509447..509452,509807..509809,
509816..509821,509840..509842,510122..510124))
/gene="fadE7"
/locus_tag="BCG_0437c"
/note="substrate binding pocket [chemical binding]; other
site"
/db_xref="CDD:173840"
misc_feature complement(509447..509449)
/gene="fadE7"
/locus_tag="BCG_0437c"
/note="catalytic base [active]"
/db_xref="CDD:173840"
gene 510604..510975
/locus_tag="BCG_0438"
/db_xref="GeneID:4696258"
CDS 510604..510975
/locus_tag="BCG_0438"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976536.1"
/db_xref="GI:121636313"
/db_xref="GeneID:4696258"
/translation="MRPRRALAGLAADVVAVLVFCAVGRRSHAEGLSVTGLAATAWPF
LTGTGIGWVLARGWRRPTALAPTGVIVWLCTIVVGMVLRKVSSAGVAASFVVVASAVT
AVLLLGWRAAVALMAPHRADG"
misc_feature 510673..510945
/locus_tag="BCG_0438"
/note="Protein of unknown function (DUF3054); Region:
DUF3054; pfam11255"
/db_xref="CDD:221047"
gene complement(511170..512273)
/gene="mmpL1b"
/locus_tag="BCG_0439c"
/db_xref="GeneID:4697008"
CDS complement(511170..512273)
/gene="mmpL1b"
/locus_tag="BCG_0439c"
/note="In Mycobacterium tuberculosis strain H37Rv, mmpL1
exists as a single gene. In Mycobacterium bovis BCG
Pasteur, and Mycobacterium bovis, a frameshift due to a
single base deletion (c-*) splits mmpL1 into 2 parts,
mmpL1a and mmpL1b"
/codon_start=1
/transl_table=11
/product="transmembrane transport protein mmpL1b"
/protein_id="YP_976537.1"
/db_xref="GI:121636314"
/db_xref="GeneID:4697008"
/translation="MNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQT
VKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPEAFQNPDFQRGL
KLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQAASIYLAGTSS
TYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVL
IWQHILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGR
VVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMTPALATLLGRWF
WWPRRVDRLARQPQVLGPRRTTALSAERAALLQ"
misc_feature complement(511233..512246)
/gene="mmpL1b"
/locus_tag="BCG_0439c"
/note="MMPL family; Region: MMPL; pfam03176"
/db_xref="CDD:146013"
gene complement(512270..514045)
/gene="mmpL1a"
/locus_tag="BCG_0440c"
/db_xref="GeneID:4695519"
CDS complement(512270..514045)
/gene="mmpL1a"
/locus_tag="BCG_0440c"
/note="In Mycobacterium tuberculosis strain H37Rv, mmpL1
exists as a single gene. In Mycobacterium bovis, a
frameshift due to a single base deletion (c-*) splits
mmpL1 into 2 parts, mmpL1a and mmpL1b;
Differs from Rv0402c by 1aa, P451L"
/codon_start=1
/transl_table=11
/product="transmembrane transport protein mmpL1a"
/protein_id="YP_976538.1"
/db_xref="GI:121636315"
/db_xref="GeneID:4695519"
/translation="MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQS
VARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLV
TKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQR
IVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAA
LIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQE
ARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVT
VMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIG
LLALPKYQTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDM
PILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVA
DLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFW
RPSEVSRTGSATASTFPSAGRCAPC"
misc_feature complement(512903..513892)
/gene="mmpL1a"
/locus_tag="BCG_0440c"
/note="MMPL family; Region: MMPL; pfam03176"
/db_xref="CDD:146013"
gene complement(514042..514470)
/gene="mmpS1"
/locus_tag="BCG_0441c"
/db_xref="GeneID:4695518"
CDS complement(514042..514470)
/gene="mmpS1"
/locus_tag="BCG_0441c"
/codon_start=1
/transl_table=11
/product="membrane protein mmpS1"
/protein_id="YP_976539.1"
/db_xref="GI:121636316"
/db_xref="GeneID:4695518"
/translation="MFGVAKRFWIPMVIVIVVAVAAVTVSRLHSVFGSHQHAPDTGNL
DPIIAFYPKHVLYEVFGPPGTVASINYLDADAQPHEVVNAAVPWSFTIVTTLTAVVAN
VVARGDGASLGCRITVNEVIREERIVNAYHAHTSCLVKSA"
misc_feature complement(514045..514461)
/gene="mmpS1"
/locus_tag="BCG_0441c"
/note="Mycobacterium membrane protein; Region:
Mycobact_memb; pfam05423"
/db_xref="CDD:114164"
gene 514791..516548
/gene="fadD30"
/locus_tag="BCG_0442"
/db_xref="GeneID:4697490"
CDS 514791..516548
/gene="fadD30"
/locus_tag="BCG_0442"
/EC_number="2.3.1.86"
/note="activates fatty acids by binding to coenzyme A"
/codon_start=1
/transl_table=11
/product="acyl-CoA synthetase"
/protein_id="YP_976540.1"
/db_xref="GI:121636317"
/db_xref="GeneID:4697490"
/translation="MSVISTLRDRATTTPSDEAFVFMDYDTKTGDQIDRMTWSQLYSR
VTAVSAYLISYGRHADRRRTAAISAPQGLDYVAGFLGALCAGWAPVPLPEPLGSLRDK
RTGLAVLDCAADVVLTTSQAETRVRATIATHGASVTTPVIALDTLDEPSGDNCDLDSQ
LSDWSSYLQYTSGSTANPRGVVLSMRNVTENVDQIIRNYFRHEGGAPRLPSSVVSWLP
LYHDMGLMVGLFIPLFVGCPVILTSPEAFIRKPARWMQLLAKHQAPFSAAPNFAFDLA
VAKTSEEDMAGLDLGHVNTIINGSEQVQPNTITKFLRRFRPYNLMPAAVKPSYGMAEA
VVYLATTKAGSPPTSTEFDADSLARGHAELSTFETERATRLIRYHSDDKEPLLRIVDP
DSNIELGPGRIGEIWIHGKNVSTGYHNADDALNRDKFQASIREASAGTPRSPWLRTGD
LGFIVGDEFYIVGRMKDLIIQDGVNHYPDDIETTVKEFTGGRVAAFSVSDDGVEHLVI
AAEVRTEHGPDKVTIMDFSTIKRLVVSALSKLHGLHVTDFLLVPPGALPKTTSGKISR
AACAKQYGANKLQRVATFP"
misc_feature 514791..516545
/gene="fadD30"
/locus_tag="BCG_0442"
/note="acyl-CoA synthetase; Validated; Region: PRK05850"
/db_xref="CDD:180288"
misc_feature 514815..516515
/gene="fadD30"
/locus_tag="BCG_0442"
/note="Fatty acyl-AMP ligase (FAAL); Region: FAAL;
cd05931"
/db_xref="CDD:213297"
misc_feature order(515292..515294,515301..515318,515322..515327)
/gene="fadD30"
/locus_tag="BCG_0442"
/note="acyl-activating enzyme (AAE) consensus motif; other
site"
/db_xref="CDD:213297"
misc_feature order(515373..515375,515451..515459,515679..515681,
515688..515699,515772..515786,515799..515801,
515922..515924,516138..516140,516171..516173,
516180..516182)
/gene="fadD30"
/locus_tag="BCG_0442"
/note="active site"
/db_xref="CDD:213297"
gene 516545..517927
/gene="pks6a"
/locus_tag="BCG_0443"
/db_xref="GeneID:4699138"
CDS 516545..517927
/gene="pks6a"
/locus_tag="BCG_0443"
/note="In Mycobacterium tuberculosis strain H37Rv, pks6
exists as a single gene. In Mycobacterium bovis BCG
Pasteur, and Mycobacterium bovis, a frameshift due to
single base insertion (*-g) splits pks6 into 2 parts,
pks6a and pks6b"
/codon_start=1
/transl_table=11
/product="membrane bound polyketide synthase pks6a"
/protein_id="YP_976541.1"
/db_xref="GI:121636318"
/db_xref="GeneID:4699138"
/translation="MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSI
DVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGR
GSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFL
KDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVS
STDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVH
LACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEG
CGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARV
DPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGI
AGLIKAGVDG"
misc_feature 516548..516793
/gene="pks6a"
/locus_tag="BCG_0443"
/note="Acyl carrier protein [Lipid metabolism / Secondary
metabolites biosynthesis, transport, and catabolism];
Region: AcpP; COG0236"
/db_xref="CDD:30585"
misc_feature 516854..>517879
/gene="pks6a"
/locus_tag="BCG_0443"
/note="Polyketide synthase modules and related proteins
[Secondary metabolites biosynthesis, transport, and
catabolism]; Region: COG3321"
/db_xref="CDD:33130"
misc_feature 516863..517879
/gene="pks6a"
/locus_tag="BCG_0443"
/note="polyketide synthases (PKSs) polymerize simple fatty
acids into a large variety of different products, called
polyketides, by successive decarboxylating Claisen
condensations. PKSs can be divided into 2 groups, modular
type I PKSs consisting of one or...; Region: PKS; cd00833"
/db_xref="CDD:29420"
misc_feature order(517346..517348,517751..517753,517871..517873)
/gene="pks6a"
/locus_tag="BCG_0443"
/note="active site"
/db_xref="CDD:29420"
gene 517914..520754
/gene="pks6b"
/locus_tag="BCG_0444"
/db_xref="GeneID:4696577"
CDS 517914..520754
/gene="pks6b"
/locus_tag="BCG_0444"
/note="In Mycobacterium tuberculosis strain H37Rv, pks6
exists as a single gene. In Mycobacterium bovis, a
frameshift due to single base insertion (*-g), splits pks6
into 2 parts, pks6a and pks6b;
Differs from Mb0413 by 1aa, M921V"
/codon_start=1
/transl_table=11
/product="membrane bound polyketide synthase pks6b"
/protein_id="YP_976542.1"
/db_xref="GI:121636319"
/db_xref="GeneID:4696577"
/translation="MLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGR
PRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALA
AQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRP
EAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYP
LRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVA
GALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVV
ISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIP
VISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLI
EASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTY
AFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEV
VCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT
PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNT
RERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYS
LTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSV
KHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLT
AAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEV
PGDHFGMMSTSSEAIATEIHDWISGLVRGPHP"
misc_feature <517917..518105
/gene="pks6b"
/locus_tag="BCG_0444"
/note="Condensing enzymes; Family of enzymes that catalyze
a (decarboxylating or non-decarboxylating) Claisen-like
condensation reaction. Members are share strong structural
similarity, and are involved in the synthesis and
degradation of fatty acids, and the...; Region:
cond_enzymes; cl09938"
/db_xref="CDD:199422"
misc_feature 518433..519263
/gene="pks6b"
/locus_tag="BCG_0444"
/note="malonyl CoA-acyl carrier protein transacylase;
Region: fabD; TIGR00128"
/db_xref="CDD:213508"
misc_feature 518445..519317
/gene="pks6b"
/locus_tag="BCG_0444"
/note="Acyl transferase domain in polyketide synthase
(PKS) enzymes; Region: PKS_AT; smart00827"
/db_xref="CDD:197897"
misc_feature 519564..519821
/gene="pks6b"
/locus_tag="BCG_0444"
/note="Phosphopantetheine attachment site; Region: PKS_PP;
smart00823"
/db_xref="CDD:197893"
misc_feature 520044..520724
/gene="pks6b"
/locus_tag="BCG_0444"
/note="Thioesterase; Region: PKS_TE; smart00824"
/db_xref="CDD:197894"
gene complement(520702..521520)
/locus_tag="BCG_0445c"
/db_xref="GeneID:4696578"
CDS complement(520702..521520)
/locus_tag="BCG_0445c"
/codon_start=1
/transl_table=11
/product="beta-lactamase"
/protein_id="YP_976543.1"
/db_xref="GI:121636320"
/db_xref="GeneID:4696578"
/translation="MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLV
TDDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHS
TPVYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQP
LTAEAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAV
FSHSQQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR"
misc_feature complement(520732..521406)
/locus_tag="BCG_0445c"
/note="Zn-dependent hydrolases, including glyoxylases
[General function prediction only]; Region: GloB; COG0491"
/db_xref="CDD:30837"
misc_feature complement(520786..521403)
/locus_tag="BCG_0445c"
/note="Metallo-beta-lactamase superfamily; Region:
Lactamase_B; smart00849"
/db_xref="CDD:197917"
gene 521598..522608
/gene="fgd1"
/locus_tag="BCG_0446"
/db_xref="GeneID:4696963"
CDS 521598..522608
/gene="fgd1"
/locus_tag="BCG_0446"
/EC_number="1.-.-.-"
/standard_name="fgd"
/codon_start=1
/transl_table=11
/product="glucose-6-phosphate dehydrogenase"
/protein_id="YP_976544.1"
/db_xref="GI:121636321"
/db_xref="GeneID:4696963"
/translation="MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPW
RHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVF
LGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGA
SIYDVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAA
DRSVDGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALP
IEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRR
LG"
misc_feature 521604..522596
/gene="fgd1"
/locus_tag="BCG_0446"
/note="glucose-6-phosphate dehydrogenase (coenzyme-F420);
Region: F420_G6P_DH; TIGR03554"
/db_xref="CDD:213827"
misc_feature 521739..>521927
/gene="fgd1"
/locus_tag="BCG_0446"
/note="Flavin-utilizing monoxygenases; Region:
Flavin_utilizing_monoxygenases; cl07892"
/db_xref="CDD:213112"
misc_feature 521862..>522257
/gene="fgd1"
/locus_tag="BCG_0446"
/note="N5,N10-methylenetetrahydromethanopterin reductase
(Mer) catalyzes the reduction of
N5,N10-methylenetetrahydromethanopterin with reduced
coenzyme F420 to N5-methyltetrahydromethanopterin and
oxidized coenzyme F420; Region:
Tetrahydromethanopterin_reductase; cd01097"
/db_xref="CDD:73246"
gene 522601..524673
/gene="pta"
/locus_tag="BCG_0447"
/db_xref="GeneID:4695793"
CDS 522601..524673
/gene="pta"
/locus_tag="BCG_0447"
/EC_number="2.3.1.8"
/note="catalyzes the synthesis of acetylphosphate or
propionylphosphate from acetyl-CoA or propionyl-CoA and
inorganic phosphate; when using propionyl-CoA the enzyme
is functioning in the anaerobic pathway catabolizing
threonine to propionate"
/codon_start=1
/transl_table=11
/product="phosphate acetyltransferase"
/protein_id="YP_976545.1"
/db_xref="GI:121636322"
/db_xref="GeneID:4695793"
/translation="MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITR
LSAERDYILELLLAHTSAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAV
VVVGSDYTDVTSPTELSVNARIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQ
RAHTAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVS
GDVALREREVMGVLAAGMTADHVLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSL
SCIVLNGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAASARGLVTATSQRKID
TALELMDRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRIL
KSAGRLLQRGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQL
RKAKGITVEHAREIMNDATYFGTMLVHNCHADGMVSGAAHTTAHTVRPALEIIKTVPG
ISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPRVAMLSY
STGDSGKGADVDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRA
TVLIFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITA
IQAQGVHE"
misc_feature 522610..524658
/gene="pta"
/locus_tag="BCG_0447"
/note="phosphate acetyltransferase; Reviewed; Region:
PRK05632"
/db_xref="CDD:235537"
misc_feature 523219..523563
/gene="pta"
/locus_tag="BCG_0447"
/note="DRTGG domain; Region: DRTGG; pfam07085"
/db_xref="CDD:219291"
misc_feature 523705..524661
/gene="pta"
/locus_tag="BCG_0447"
/note="phosphotransacetylase; Reviewed; Region: eutD;
PRK09653"
/db_xref="CDD:236609"
gene 524666..525823
/gene="ackA"
/locus_tag="BCG_0448"
/db_xref="GeneID:4697315"
CDS 524666..525823
/gene="ackA"
/locus_tag="BCG_0448"
/EC_number="2.7.2.1"
/note="AckA utilizes acetate and can acetylate CheY which
increases signal strength during flagellar rotation;
utilizes magnesium and ATP; also involved in conversion of
acetate to aceyl-CoA"
/codon_start=1
/transl_table=11
/product="acetate kinase"
/protein_id="YP_976546.1"
/db_xref="GI:121636323"
/db_xref="GeneID:4697315"
/translation="MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVA
DHAQALHRAFKMLAEDGIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSA
LAPLHNPPAVLGIKVARRLLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRR
YGFHGTSHQYVSERAAAFLGRPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLE
GLVMGTRSGDLDPGVISYLWRTARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIET
GDRSAQLAYEVFIHRLRKYLGAYLAVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLG
IALDQDRNLGPGHGARRISSDDSPIAVLVVPTNEELAIARDCLRVLGGRRA"
misc_feature 524672..525802
/gene="ackA"
/locus_tag="BCG_0448"
/note="propionate/acetate kinase; Provisional; Region:
PRK12379"
/db_xref="CDD:183484"
misc_feature 524678..525814
/gene="ackA"
/locus_tag="BCG_0448"
/note="acetate kinase A/propionate kinase 2; Reviewed;
Region: PRK00180"
/db_xref="CDD:234680"
gene complement(525877..528129)
/gene="pknG"
/locus_tag="BCG_0449c"
/db_xref="GeneID:4698962"
CDS complement(525877..528129)
/gene="pknG"
/locus_tag="BCG_0449c"
/EC_number="2.7.1.-"
/codon_start=1
/transl_table=11
/product="Serine/threonine-protein kinase pknG"
/protein_id="YP_976547.1"
/db_xref="GI:121636324"
/db_xref="GeneID:4698962"
/translation="MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDED
NFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPES
KRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHG
GLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVE
HTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYND
LKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRT
LAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQL
TGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIV
TALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLME
VRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTF
PGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVR
TLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIR
ALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDM
ANKVRPTSTF"
misc_feature complement(526966..527679)
/gene="pknG"
/locus_tag="BCG_0449c"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:214567"
misc_feature complement(526972..527661)
/gene="pknG"
/locus_tag="BCG_0449c"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature complement(order(527197..527208,527242..527244,
527251..527253,527281..527283,527287..527292,
527296..527298,527302..527304,527407..527409,
527413..527415,527425..527436,527497..527499,
527587..527589,527593..527595,527635..527637,
527647..527661))
/gene="pknG"
/locus_tag="BCG_0449c"
/note="active site"
/db_xref="CDD:173623"
misc_feature complement(order(527251..527253,527281..527283,
527287..527292,527296..527298,527302..527304,
527413..527415,527425..527436,527497..527499,
527587..527589,527593..527595,527635..527637,
527647..527661))
/gene="pknG"
/locus_tag="BCG_0449c"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature complement(order(527197..527208,527242..527244,
527290..527292,527296..527298,527302..527304,
527407..527409,527413..527415,527647..527649))
/gene="pknG"
/locus_tag="BCG_0449c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature complement(order(527197..527208,527236..527256))
/gene="pknG"
/locus_tag="BCG_0449c"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
gene complement(528129..529115)
/gene="glnH"
/locus_tag="BCG_0450c"
/db_xref="GeneID:4697522"
CDS complement(528129..529115)
/gene="glnH"
/locus_tag="BCG_0450c"
/codon_start=1
/transl_table=11
/product="glutamine-binding lipoprotein glnH"
/protein_id="YP_976548.1"
/db_xref="GI:121636325"
/db_xref="GeneID:4697522"
/translation="MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPT
PVGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDIGS
NLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVV
KTMSITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDLSGKRVCVARGTTSLRRIR
EIAPPPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPY
GVGINLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD"
misc_feature complement(528180..528836)
/gene="glnH"
/locus_tag="BCG_0450c"
/note="Bacterial periplasmic transport systems use
membrane-bound complexes and substrate-bound,
membrane-associated, periplasmic binding proteins (PBPs)
to transport a wide variety of substrates, such as, amino
acids, peptides, sugars, vitamins and inorganic...;
Region: PBPb; cd00134"
/db_xref="CDD:29040"
misc_feature complement(528180..528836)
/gene="glnH"
/locus_tag="BCG_0450c"
/note="Bacterial extracellular solute-binding proteins,
family 3; Region: SBP_bac_3; pfam00497"
/db_xref="CDD:201266"
misc_feature complement(order(528366..528368,528480..528482,
528609..528611,528684..528686,528810..528812))
/gene="glnH"
/locus_tag="BCG_0450c"
/note="substrate binding pocket [chemical binding]; other
site"
/db_xref="CDD:29040"
misc_feature complement(order(528387..528389,528405..528407,
528417..528419))
/gene="glnH"
/locus_tag="BCG_0450c"
/note="membrane-bound complex binding site; other site"
/db_xref="CDD:29040"
misc_feature complement(528279..528296)
/gene="glnH"
/locus_tag="BCG_0450c"
/note="hinge residues; other site"
/db_xref="CDD:29040"
gene complement(529115..530434)
/locus_tag="BCG_0451c"
/db_xref="GeneID:4697947"
CDS complement(529115..530434)
/locus_tag="BCG_0451c"
/note="Differs from Rv0412c by 1aa, Y355D"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976549.1"
/db_xref="GI:121636326"
/db_xref="GeneID:4697947"
/translation="MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLA
ALGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAE
PGGVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRA
GNPVGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVV
FGAFAHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLK
TITNLAITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPD
LQGADQLLVRWRQANDRINSYISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMG
QSRTQLRHDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR"
gene 530528..531181
/gene="mutT3"
/locus_tag="BCG_0452"
/db_xref="GeneID:4696193"
CDS 530528..531181
/gene="mutT3"
/locus_tag="BCG_0452"
/EC_number="3.6.1.-"
/codon_start=1
/transl_table=11
/product="mutator protein MutT3"
/protein_id="YP_976550.1"
/db_xref="GI:121636327"
/db_xref="GeneID:4696193"
/translation="MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRP
DGTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQTAVRESSEEAGLSAERLEVRAT
VVTAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAAS
WQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL"
misc_feature 530627..531022
/gene="mutT3"
/locus_tag="BCG_0452"
/note="NUDIX domain; Region: NUDIX; pfam00293"
/db_xref="CDD:215841"
misc_feature order(530735..530743,530771..530797)
/gene="mutT3"
/locus_tag="BCG_0452"
/note="nudix motif; other site"
/db_xref="CDD:239217"
gene complement(531165..531833)
/gene="thiE"
/locus_tag="BCG_0453c"
/db_xref="GeneID:4695711"
CDS complement(531165..531833)
/gene="thiE"
/locus_tag="BCG_0453c"
/EC_number="2.5.1.3"
/note="Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole
monophosphate and 4-amino-5-hydroxymethyl pyrimidine
pyrophosphate to form thiamine monophosphate"
/codon_start=1
/transl_table=11
/product="thiamine-phosphate pyrophosphorylase"
/protein_id="YP_976551.1"
/db_xref="GI:121636328"
/db_xref="GeneID:4695711"
/translation="MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDK
GSPGELRFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQRDL
PVNVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKPGRAAPGLGLV
RVAAELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSAL
TAAN"
misc_feature complement(531186..531803)
/gene="thiE"
/locus_tag="BCG_0453c"
/note="Thiamine monophosphate synthase (TMP
synthase)/TenI. TMP synthase catalyzes an important step
in the thiamine biosynthesis pathway, the substitution of
the pyrophosphate of 2-methyl-4-amino-5-
hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-;
Region: TMP_TenI; cd00564"
/db_xref="CDD:238317"
misc_feature complement(order(531237..531248,531300..531302,
531312..531314,531390..531392,531396..531398,
531417..531419,531423..531425,531474..531476,
531546..531548,531708..531710,531714..531716,
531792..531794,531798..531800))
/gene="thiE"
/locus_tag="BCG_0453c"
/note="thiamine phosphate binding site [chemical binding];
other site"
/db_xref="CDD:238317"
misc_feature complement(order(531237..531242,531300..531302,
531387..531392,531396..531398,531474..531476,
531531..531533,531588..531593,531702..531704,
531708..531710,531714..531716))
/gene="thiE"
/locus_tag="BCG_0453c"
/note="active site"
/db_xref="CDD:238317"
misc_feature complement(order(531387..531389,531474..531476,
531531..531533,531540..531542,531588..531593,
531702..531704,531708..531710))
/gene="thiE"
/locus_tag="BCG_0453c"
/note="pyrophosphate binding site [ion binding]; other
site"
/db_xref="CDD:238317"
gene 531963..532985
/gene="thiO"
/locus_tag="BCG_0454"
/db_xref="GeneID:4695451"
CDS 531963..532985
/gene="thiO"
/locus_tag="BCG_0454"
/EC_number="1.-.-.-"
/note="Differs from Rv0415 by 1aa, A158V"
/codon_start=1
/transl_table=11
/product="thiamine biosynthesis oxidoreductase thiO"
/protein_id="YP_976552.1"
/db_xref="GI:121636329"
/db_xref="GeneID:4695451"
/translation="MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSDERGAS
WVAGGMLAPHSEGWPGEERLLRLGLQSLRLWREGSFLDGLGPQLVTAHESLVVAVDRA
DVADLRTVADWLSAQGHPVIWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDALC
RDCERLGVRWSSQVSSLSDVDAHTVVIANGIDAPALWPGLPIRPVKGEVLRLRWRPGC
MPLPQRVIRARVRGRQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLP
ALGEYELAECEAGLRPMTPDNLPLVQRLDSRTLVAAGHGRSGFLLAPWTAEQIVSELV
SVGAAS"
misc_feature 531990..>532103
/gene="thiO"
/locus_tag="BCG_0454"
/note="NADP oxidoreductase coenzyme F420-dependent;
Region: F420_oxidored; cl17232"
/db_xref="CDD:247786"
misc_feature 532032..532973
/gene="thiO"
/locus_tag="BCG_0454"
/note="glycine oxidase ThiO; Region: thiamin_ThiO;
TIGR02352"
/db_xref="CDD:233831"
gene 532982..533188
/gene="thiS"
/locus_tag="BCG_0455"
/db_xref="GeneID:4697958"
CDS 532982..533188
/gene="thiS"
/locus_tag="BCG_0455"
/note="with ThiF, ThiG, and ThiO catalyzes the formation
of the thiazole moiety of thiamine pyrophosphate"
/codon_start=1
/transl_table=11
/product="sulfur carrier protein ThiS"
/protein_id="YP_976553.1"
/db_xref="GI:121636330"
/db_xref="GeneID:4697958"
/translation="MIVVVNEQQVEVDEQTTIAALLDSLGFGDRGIAVALNFSVLPRS
DWATKICELRKPVRLEVVTAVQGG"
misc_feature <533027..533185
/gene="thiS"
/locus_tag="BCG_0455"
/note="ThiaminS ubiquitin-like sulfur carrier protein;
Region: ThiS; cd00565"
/db_xref="CDD:176353"
misc_feature order(533099..533101,533159..533167)
/gene="thiS"
/locus_tag="BCG_0455"
/note="thiS-thiF/thiG interaction site; other site"
/db_xref="CDD:176353"
gene 533181..533939
/gene="thiG"
/locus_tag="BCG_0456"
/db_xref="GeneID:4697959"
CDS 533181..533939
/gene="thiG"
/locus_tag="BCG_0456"
/note="functions in thiamine (vitamin B1) biosynthesis; in
Bacillus subtilis this enzyme catalyzes the formation of
thiazole from dehydroxyglycine and
1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate"
/codon_start=1
/transl_table=11
/product="thiazole synthase"
/protein_id="YP_976554.1"
/db_xref="GI:121636331"
/db_xref="GeneID:4697959"
/translation="MAESKLVIGDRSFASRLIMGTGGATNLAVLEQALIASGTELTTV
AIRRVDADGGTGLLDLLNRLGITPLPNTAGCRSAAEAVLTAQLAREALNTNWVKLEVI
ADERTLWPDAVELVRAAEQLVDDGFVVLPYTTDDPVLARRLEDTGCAAVMPLGSPIGT
GLGIANPHNIEMIVAGARVPVVLDAGIGTASDAALAMELGCDAVLLASAVTRAADPPA
MAAAMAAAVTAGYLARCAGRIPKRFWAQASSPAR"
misc_feature 533196..533930
/gene="thiG"
/locus_tag="BCG_0456"
/note="Thiazole synthase (ThiG) is the tetrameric enzyme
that is involved in the formation of the thiazole moiety
of thiamin pyrophosphate, an essential ubiquitous cofactor
that plays an important role in carbohydrate and amino
acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728"
/db_xref="CDD:240079"
misc_feature order(533313..533315,533352..533354,533361..533363)
/gene="thiG"
/locus_tag="BCG_0456"
/note="ThiS interaction site; other site"
/db_xref="CDD:240079"
misc_feature order(533472..533474,533478..533480,533730..533732)
/gene="thiG"
/locus_tag="BCG_0456"
/note="putative active site [active]"
/db_xref="CDD:240079"
misc_feature order(533487..533489,533496..533498,533505..533513,
533580..533582,533586..533594,533601..533606,
533658..533666,533673..533675,533691..533693,
533703..533705,533745..533753,533763..533765,
533772..533777,533802..533804,533817..533825,
533832..533837,533844..533846,533865..533867,
533874..533879,533883..533897,533901..533906,
533910..533912,533916..533924,533928..533930)
/gene="thiG"
/locus_tag="BCG_0456"
/note="tetramer interface [polypeptide binding]; other
site"
/db_xref="CDD:240079"
gene 534311..535813
/gene="lpqL"
/locus_tag="BCG_0457"
/db_xref="GeneID:4695452"
CDS 534311..535813
/gene="lpqL"
/locus_tag="BCG_0457"
/EC_number="3.4.11.-"
/codon_start=1
/transl_table=11
/product="lipoprotein aminopeptidase lpqL"
/protein_id="YP_976555.1"
/db_xref="GI:121636332"
/db_xref="GeneID:4695452"
/translation="MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEF
AVALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQT
PEFSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDY
DRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIP
VVSVTKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVP
EGPGINDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDA
LKGIALYLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAG
KTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQK
TDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP"
misc_feature 534437..535801
/gene="lpqL"
/locus_tag="BCG_0457"
/note="Predicted aminopeptidases [General function
prediction only]; Region: Iap; COG2234"
/db_xref="CDD:225143"
misc_feature 534461..>534637
/gene="lpqL"
/locus_tag="BCG_0457"
/note="Zinc peptidases M18, M20, M28, and M42; Region:
Zinc_peptidase_like; cl14876"
/db_xref="CDD:246748"
misc_feature 534680..535039
/gene="lpqL"
/locus_tag="BCG_0457"
/note="PA_SaNapH_like: Protease-associated domain
containing proteins like Streptomyces anulatus
N-acetylpuromycin N-acetylhydrolase (SaNapH).This group
contains various PA domain-containing proteins similar
SaNapH. Proteins in this group belong to the...; Region:
PA_SaNapH_like; cd04816"
/db_xref="CDD:240120"
misc_feature 534917..534925
/gene="lpqL"
/locus_tag="BCG_0457"
/note="PA/protease or protease-like domain interface
[polypeptide binding]; other site"
/db_xref="CDD:240120"
misc_feature 535034..535705
/gene="lpqL"
/locus_tag="BCG_0457"
/note="M28 Zn-peptidase Streptomyces griseus
Aminopeptidase and similar proteins; Region:
M28_SGAP_like; cd03876"
/db_xref="CDD:193498"
misc_feature order(535121..535123,535157..535162,535256..535261,
535343..535348,535508..535510,535517..535522,
535568..535570,535649..535654)
/gene="lpqL"
/locus_tag="BCG_0457"
/note="active site"
/db_xref="CDD:193498"
misc_feature order(535121..535123,535157..535159,535259..535261,
535343..535345,535652..535654)
/gene="lpqL"
/locus_tag="BCG_0457"
/note="metal binding site [ion binding]; metal-binding
site"
/db_xref="CDD:193498"
gene 535901..537397
/gene="lpqM"
/locus_tag="BCG_0458"
/db_xref="GeneID:4698190"
CDS 535901..537397
/gene="lpqM"
/locus_tag="BCG_0458"
/EC_number="3.4.11.-"
/note="Differs from Rv0419 by 2aa, T73A, T297A, and from
Mb0427 by 1aa, T73A"
/codon_start=1
/transl_table=11
/product="lipoprotein peptidase lpqM"
/protein_id="YP_976556.1"
/db_xref="GI:121636333"
/db_xref="GeneID:4698190"
/translation="MHGRGRYRPLVRCVRPRRVAASVRTPIACLAAVVVIAGCTTVVD
GRALSILNDPFRVGGLPATNGPSGARPDTPAASGTVINTNNGAIDKLSLLSVNDIEDY
WMAVYSESLKGTFRPVGKLVSYDSNDPSSPIVCHIDTYQLVNAFFSSRCNLIAWDRGV
FMAVAQEYFGDMSVNGVLAHEFGHALQVMANLVTRKDPTIVREQQADCFAGVYLWWVA
EGKSTRFTLSTADGLDHVLAGIITTRDPVMEADAENDDEHGSALDRVSAFQLGFINGT
PACAAIDEDEVERRRGDLPTTLRVDASGNPETGEVGINEETLSTLMELMGKIFSPKNP
PTLSYQPAGCPDAKPSPPAAYCPATNTIVVDLPALARMGKVASAAEHSLPQGDDTSLS
IVMSRYALAVQHERGLPMQSPWTALRTACLTGVAHRKMAVPIDLPSGQQLVLTAGDLD
EAVSGLLTNRMVASDADGVSVPAGFTRIAAFRAGVGGDMDACYARYPG"
misc_feature 535901..536764
/gene="lpqM"
/locus_tag="BCG_0458"
/note="Predicted metalloprotease [General function
prediction only]; Region: COG2321"
/db_xref="CDD:32475"
gene complement(537376..537786)
/locus_tag="BCG_0459c"
/db_xref="GeneID:4698191"
CDS complement(537376..537786)
/locus_tag="BCG_0459c"
/note="Differs from Rv0420c by 1aa, G21E"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976557.1"
/db_xref="GI:121636334"
/db_xref="GeneID:4698191"
/translation="MRLHDASAAAPESRMHIARHGEAVNRRQMFIGITGLLLAVIGLM
ALWFPVYLDQYDAYGIKVTCGSGWRSNLTQALYADGNDNTQALVTRCDTALLVRRAWA
IPSVALGWLLVTGFLVMWVHNDQHQGQSYPGYRA"
gene complement(537947..538576)
/locus_tag="BCG_0460c"
/db_xref="GeneID:4695996"
CDS complement(537947..538576)
/locus_tag="BCG_0460c"
/codon_start=1
/transl_table=11
/product="hypothetical protein"
/protein_id="YP_976558.1"
/db_xref="GI:121636335"
/db_xref="GeneID:4695996"
/translation="MNLDQIAGVAHQPAGPPHGVVVLTHGAGGSRESTLLQQVCAEWT
RRGWLAVRYNLPYRRRRPTGPPSGSGSGDRAGIVEAIQLCRGLAEGPLIAGGHSYGGR
QTSMVVAAGQAPVDVLTLFSYPVHPPGKPERVRTEHLPGIAVPTVFTHGTADPFGTLA
QVRSAAAMVSAPTEVVEITGARHDLGSKTLDVARLAVDAALRLSAGQIA"
misc_feature complement(538028..538519)
/locus_tag="BCG_0460c"
/note="Alpha/beta hydrolase family; Region: Abhydrolase_5;
pfam12695"
/db_xref="CDD:221718"
gene complement(538573..539370)
/gene="thiD"
/locus_tag="BCG_0461c"
/db_xref="GeneID:4696047"
CDS complement(538573..539370)
/gene="thiD"
/locus_tag="BCG_0461c"
/EC_number="2.7.4.7"
/note="catalyzes the formation of
4-amino-2-methyl-5-diphosphomethylpyrimidine"
/codon_start=1
/transl_table=11
/product="phosphomethylpyrimidine kinase"
/protein_id="YP_976559.1"
/db_xref="GI:121636336"
/db_xref="GeneID:4696047"
/translation="MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQ
NTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVP
LVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRA
AAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLAT
AIAAALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS"
misc_feature complement(538627..539301)
/gene="thiD"
/locus_tag="BCG_0461c"
/note="4-amino-5-hydroxymethyl-2-methyl-pyrimidine
phosphate kinase (HMPP-kinase) catalyzes two consecutive
phosphorylation steps in the thiamine phosphate
biosynthesis pathway, leading to the synthesis of vitamin
B1. The first step is the phosphorylation of...; Region:
HMPP_kinase; cd01169"
/db_xref="CDD:238574"
misc_feature complement(order(539170..539175,539185..539187,
539194..539196,539203..539208,539212..539214,
539218..539223,539236..539250,539257..539259,
539263..539280,539287..539289,539296..539301))
/gene="thiD"
/locus_tag="BCG_0461c"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:238574"
misc_feature complement(order(538729..538731,539131..539133,
539239..539241))
/gene="thiD"
/locus_tag="BCG_0461c"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:238574"
misc_feature complement(order(538732..538734,538738..538740,
538843..538845,538942..538944,539053..539055))
/gene="thiD"
/locus_tag="BCG_0461c"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:238574"
gene complement(539397..541040)
/gene="thiC"
/locus_tag="BCG_0462c"
/db_xref="GeneID:4695450"
CDS complement(539397..541040)
/gene="thiC"
/locus_tag="BCG_0462c"
