LOCUS NC_001145 924431 bp DNA linear CON 15-SEP-2023
DEFINITION Saccharomyces cerevisiae S288C chromosome XIII, complete sequence.
ACCESSION NC_001145
VERSION NC_001145.3
DBLINK BioProject: PRJNA128
Assembly: GCF_000146045.2
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 924431)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (bases 1 to 924431)
AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T.,
Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S.,
Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M.,
Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII
JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997)
PUBMED 9169872
REFERENCE 3 (bases 1 to 924431)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (bases 1 to 924431)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (14-SEP-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (bases 1 to 924431)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (bases 1 to 924431)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 7 (bases 1 to 924431)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to BK006946.
On Apr 26, 2011 this sequence version replaced NC_001145.2.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
FEATURES Location/Qualifiers
source 1..924431
/organism="Saccharomyces cerevisiae S288C"
/mol_type="genomic DNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XIII"
telomere complement(1..6344)
/note="TEL13L; Telomeric region on the left arm of
Chromosome XIII; composed of an X element core sequence, X
element combinatorial repeats, a short region of telomeric
repeats, a short Y' element, and a short terminal region
of telomeric repeats"
/db_xref="SGD:S000028918"
gene complement(<461..>4684)
/locus_tag="YML133C"
/db_xref="GeneID:854906"
mRNA complement(join(<461..3791,3891..>4684))
/locus_tag="YML133C"
/product="Y' element ATP-dependent helicase"
/transcript_id="NM_001182496.1"
/db_xref="GeneID:854906"
CDS complement(join(461..3791,3891..4684))
/locus_tag="YML133C"
/EC_number="3.6.4.12"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/note="Putative Y' element ATP-dependent helicase; the
authentic, non-tagged protein is detected in highly
purified mitochondria in high-throughput studies; YML133C
contains an intron"
/codon_start=1
/product="Y' element ATP-dependent helicase"
/protein_id="NP_013573.1"
/db_xref="GeneID:854906"
/db_xref="SGD:S000004602"
/translation="MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVR
SFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPI
PSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEIA
SARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRRYGYNLAPHMFLLLHVDELSIFSAYQ
ASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDVLATAQRIRRRYN
KNSSSEPRLKTLDGLTSERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKIS
RVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGY
GKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEG
CDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVY
RQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSED
LSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAI
VVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTE
GIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKE
GCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSI
VALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRT
SATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNS
NTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTEST
NASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNV
LQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRM
AWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLA
ITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEK
KCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYEL
SLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHW
VDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE"
gene <7244..>8383
/gene="COS3"
/locus_tag="YML132W"
/db_xref="GeneID:854907"
mRNA <7244..>8383
/gene="COS3"
/locus_tag="YML132W"
/product="Cos3p"
/transcript_id="NM_001182495.1"
/db_xref="GeneID:854907"
CDS 7244..8383
/gene="COS3"
/locus_tag="YML132W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:14562095|PMID:14718542|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005768 endosome
[PMID:25942624]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:14718542]"
/experiment="EXISTENCE:mutant phenotype:GO:0006883
intracellular sodium ion homeostasis [PMID:14718542]"
/note="Endosomal protein involved in turnover of plasma
membrane proteins; member of the DUP380 subfamily of
conserved, often subtelomeric COS genes; required for the
multivesicular vesicle body sorting pathway that
internalizes plasma membrane proteins for degradation; Cos
proteins provide ubiquitin in trans for nonubiquitinated
cargo proteins"
/codon_start=1
/product="Cos3p"
/protein_id="NP_013574.1"
/db_xref="GeneID:854907"
/db_xref="SGD:S000004601"
/translation="MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIY
KSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQ
LIQFCKEITENTPSSDPHDWEVVAANLNSYLYENNVWNTKYFFFNAMVCQEAFRTTLL
EPFSLKKDKAAKVKSFKDSVPYIEEALGVYFTEVEKQWKLFNTEKSWSPVGLEDAKLP
KEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTLYLGWILFMLVQGFQ
NIRVLIMSMEHKMQFLSTIINEQESGANGWDEIARKMNRYLFEKKAWKNEEFFFDGID
CEWFFNHFFYRVLSAKKSMWPLPLNVELWPYIKEAQLSRSEVLLV"
gene <10198..>11295
/locus_tag="YML131W"
/db_xref="GeneID:854908"
mRNA <10198..>11295
/locus_tag="YML131W"
/product="uncharacterized protein"
/transcript_id="NM_001182494.1"
/db_xref="GeneID:854908"
CDS 10198..11295
/locus_tag="YML131W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/note="hypothetical protein; similar to medium chain
dehydrogenase/reductases; expression induced by stresses
including osmotic shock, DNA damaging agents, and other
chemicals; GFP-fusion protein localizes to the cytoplasm;
protein abundance increases in response to DNA replication
stress"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013575.1"
/db_xref="GeneID:854908"
/db_xref="SGD:S000004600"
/translation="MVLAKQWVLKNLPTPGEPFNFHFHDPACTFELIEKELSSEQLKD
GELLLETTYLSNDPAQKFWISSMDKNYAKGVQPGEIIPARGIGKVLASRNKAFSPGDY
VSAVTGWTTHAIISQENVQGLRKLDKNKVGKLWWYLSVLGGTSLTAYFIFFTYAQLQE
REEDYGKVYLISGAAGAVGTVCIQLALNVFKASKVIAIAGGPEKVAFVESFGDNVVGV
DYKDPSFKQKLIEAAGGENTVDYFIDNVGSNVLEAGVLLLKQRAMLIACGAISAYNDP
SKFVFKGYSFILTKRLVVKGVLVTDNIDDFPKALDKLGSLVKHGKIDLLKSATLEDGT
GDKFKNVPLIWKGLFSGVNKGKLITKVNNEE"
gene complement(<11483..>13174)
/gene="ERO1"
/locus_tag="YML130C"
/db_xref="GeneID:854909"
mRNA complement(<11483..>13174)
/gene="ERO1"
/locus_tag="YML130C"
/product="ER oxidoreductin"
/transcript_id="NM_001182493.1"
/db_xref="GeneID:854909"
CDS complement(11483..13174)
/gene="ERO1"
/locus_tag="YML130C"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762|PMID:9659914]"
/experiment="EXISTENCE:direct assay:GO:0016972 thiol
oxidase activity [PMID:16407158]"
/experiment="EXISTENCE:mutant phenotype:GO:0034975 protein
folding in endoplasmic reticulum [PMID:9659913]"
/note="Thiol oxidase required for oxidative protein
folding in the ER; essential for maintaining ER redox
balance; feedback regulated via reduction and oxidation of
regulatory bonds; reduced Pdi1p activates Ero1p by direct
reduction of Ero1p regulatory bonds; depletion of thiol
substrates and accumulation of oxidized Pdi1p results in
inactivation of Ero1p by both Pdi1p-mediated oxidation and
autonomous oxidation of Ero1p regulatory bonds; ero1-1
mutation complemented by human ERO1L"
/codon_start=1
/product="ER oxidoreductin"
/protein_id="NP_013576.1"
/db_xref="GeneID:854909"
/db_xref="SGD:S000004599"
/translation="MRLRTAIATLCLTAFTSATSNNSYIATDQTQNAFNDTHFCKVDR
NDHVSPSCNVTFNELNAINENIRDDLSALLKSDFFKYFRLDLYKQCSFWDANDGLCLN
RACSVDVVEDWDTLPEYWQPEILGSFNNDTMKEADDSDDECKFLDQLCQTSKKPVDIE
DTINYCDVNDFNGKNAVLIDLTANPERFTGYGGKQAGQIWSTIYQDNCFTIGETGESL
AKDAFYRLVSGFHASIGTHLSKEYLNTKTGKWEPNLDLFMARIGNFPDRVTNMYFNYA
VVAKALWKIQPYLPEFSFCDLVNKEIKNKMDNVISQLDTKIFNEDLVFANDLSLTLKD
EFRSRFKNVTKIMDCVQCDRCRLWGKIQTTGYATALKILFEINDADEFTKQHIVGKLT
KYELIALLQTFGRLSESIESVNMFEKMYGKRLNGSENRLSSFFQNNFFNILKEAGKSI
RYTIENINSTKEGKKKTNNSQSHVFDDLKMPKAEIVPRPSNGTVNKWKKAWNTEVNNV
LEAFRFIYRSYLDLPRNIWELSLMKVYKFWNKFIGVADYVSEETREPISYKLDIQ"
gene complement(<14541..>14753)
/gene="COX14"
/locus_tag="YML129C"
/db_xref="GeneID:854910"
mRNA complement(<14541..>14753)
/gene="COX14"
/locus_tag="YML129C"
/product="Cox14p"
/transcript_id="NM_001182492.1"
/db_xref="GeneID:854910"
CDS complement(14541..14753)
/gene="COX14"
/locus_tag="YML129C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005740
mitochondrial envelope [PMID:7797555]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:15306853]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:15306853]"
/experiment="EXISTENCE:mutant phenotype:GO:0033617
mitochondrial cytochrome c oxidase assembly
[PMID:21068384|PMID:7797555]"
/experiment="EXISTENCE:physical interaction:GO:0070130
negative regulation of mitochondrial translation
[PMID:15306853]"
/note="Mitochondrial cytochrome c oxidase (complex IV)
assembly factor; also involved in translational regulation
of Cox1p and prevention of Cox1p aggregation before
assembly; associates with complex IV assembly
intermediates and complex III/complex IV supercomplexes;
located in the mitochondrial membrane"
/codon_start=1
/product="Cox14p"
/protein_id="NP_013577.1"
/db_xref="GeneID:854910"
/db_xref="SGD:S000004598"
/translation="MSKYAWYTRVTDTLHRLTVLTLVGGTLYMSGGLAYTLYMNGKKY
EQQVTQQKALEEDNQQLQSPTAPPTE"
gene complement(<15135..>16676)
/gene="MSC1"
/locus_tag="YML128C"
/db_xref="GeneID:854911"
mRNA complement(<15135..>16676)
/gene="MSC1"
/locus_tag="YML128C"
/product="Msc1p"
/transcript_id="NM_001182491.1"
/db_xref="GeneID:854911"
CDS complement(15135..16676)
/gene="MSC1"
/locus_tag="YML128C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:11502169|PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836]"
/experiment="EXISTENCE:mutant phenotype:GO:0007131
reciprocal meiotic recombination [PMID:10511544]"
/note="hypothetical protein; mutant is defective in
directing meiotic recombination events to homologous
chromatids; the authentic, non-tagged protein is detected
in highly purified mitochondria and is phosphorylated"
/codon_start=1
/product="Msc1p"
/protein_id="NP_013578.1"
/db_xref="GeneID:854911"
/db_xref="SGD:S000004597"
/translation="MKQFKLVNAVSASFVLIGLVLANSDSVFDKWTQEDLADYLRDNK
KSLEKYATDSIEDLKTEASQVWDKHAQPKPWWQVWSSDSSSVSNSNPGWFGYTGSSDH
PVSDWLFDTWSTDSLRNFLKKNGVDVDDAKASKDSLVKTAKENFNKISKSLKSSGYYP
SSSYFDSWSTKDLQNWLNDNGIDYDKAVQSKDELVQKVKENIYRTSEKAEQQRLGLLE
SLDLAHQQILDTSGQIKDTVFDKWSSDQLTNWLESHKVNIDKNMAKKHDYLVRMAKEN
SANLKDDIYWYLDYMKRESSPFLTKTPEYVGSVWDSSKNFLTNLYSKFRGKTDNVIND
TFLVGLDSWPKDKLKMFLDARGIKYSMLSTEHQLRELVKKSRNEKLKILPKDYQKYFD
NSNWSLDDIKGWFADKKDDFQDSQTYSTIMQDFDKVSKNTNDAKDQIAKTWSNTFQSW
SQEDLLQYLKSFGVPVKQTSTKDDLINLAKQNTQWLFGTVKEPAYKRYLHNVKNWSKS
ILGFN"
gene <17064..>18809
/gene="RSC9"
/locus_tag="YML127W"
/db_xref="GeneID:854912"
mRNA <17064..>18809
/gene="RSC9"
/locus_tag="YML127W"
/product="Rsc9p"
/transcript_id="NM_001182490.1"
/db_xref="GeneID:854912"
CDS 17064..18809
/gene="RSC9"
/locus_tag="YML127W"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:11931764]"
/experiment="EXISTENCE:direct assay:GO:0006337 nucleosome
disassembly [PMID:16492771]"
/experiment="EXISTENCE:direct assay:GO:0006338 chromatin
remodeling [PMID:12183366]"
/experiment="EXISTENCE:direct assay:GO:0006368
transcription elongation by RNA polymerase II
[PMID:17081996]"
/experiment="EXISTENCE:direct assay:GO:0016586 RSC-type
complex [PMID:10619019|PMID:11931764|PMID:12183366]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:11931764]"
/experiment="EXISTENCE:mutant phenotype:GO:0009303 rRNA
transcription [PMID:11931764]"
/note="Component of the RSC chromatin remodeling complex;
DNA-binding protein involved in the synthesis of rRNA and
in transcriptional repression and activation of genes
regulated by the Target of Rapamycin (TOR) pathway"
/codon_start=1
/product="Rsc9p"
/protein_id="NP_013579.1"
/db_xref="GeneID:854912"
/db_xref="SGD:S000004596"
/translation="MNSLASNTPLNGTPVSEAPATSSEPVNMFETMVANPIKVSRLQS
NGVLTGPAANTKSIHYSLANFNVFQSLPKETARGVDDLTRMEMALLSGIPEEIKWSLK
KYLTYSNKAPYMISLRTLPDLLPLFKTFILPLERIVEGLNKSSICDSKAMDSLQMGLN
ALLILRNLAQDTDSVQILVKDREIKSFILFILKKFQCVATGDNKWQLYEGNATFFNEL
THYTLDLMEAISSYIAPAMKDDHYFQTLVSILNYTKDRYMVISILRSLSRLLVRSKAN
EESAADNLDHKTLSLIVSFLLLECDSELIIASLDFLYQYILPGSQRITELFKSKECSL
ILEATLPNLLSYNIATPDYHLLQKHKIRLIKRLKPPAPKEPPNLSEDLFQQLFKLNEP
LRSTAWLRCCFEPVQEAEFTQISLWRSYESKFGQPVRESGRKLLPAVEFIKNVSNAFN
NAAAIVITDPVTGKKRFVIKGIQPRFKALGIADGERESQVPISALKSKFLNDSKEITP
ARQNSIPEVKFPQELSDVSKVACTFLCLLSNDTDDGAGSAFCQRIRPLVLHKLADIPP
LTLALSEYMENTSGL"
gene complement(<19060..>20535)
/gene="ERG13"
/locus_tag="YML126C"
/gene_synonym="HMGS"
/db_xref="GeneID:854913"
mRNA complement(<19060..>20535)
/gene="ERG13"
/locus_tag="YML126C"
/gene_synonym="HMGS"
/product="hydroxymethylglutaryl-CoA synthase"
/transcript_id="NM_001182489.1"
/db_xref="GeneID:854913"
CDS complement(19060..20535)
/gene="ERG13"
/locus_tag="YML126C"
/gene_synonym="HMGS"
/EC_number="2.3.3.10"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0004421
hydroxymethylglutaryl-CoA synthase activity
[PMID:6148937|PMID:12702274]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process
[PMID:6148937|PMID:12702274]"
/note="3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase;
catalyzes the formation of HMG-CoA from acetyl-CoA and
acetoacetyl-CoA; involved in the second step in mevalonate
biosynthesis"
/codon_start=1
/product="hydroxymethylglutaryl-CoA synthase"
/protein_id="NP_013580.1"
/db_xref="GeneID:854913"
/db_xref="SGD:S000004595"
/translation="MKLSTKLCWCGIKGRLRPQKQQQLHNTNLQMTELKKQKTAEQKT
RPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDREDIYSMSL
TVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGENTDVEGIDTLNACY
GGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIGPDAPIV
FDSVRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSKKAISKGLVS
DPAGSDALNVLKYFDYNVFHVPTCKLVTKSYGRLLYNDFRANPQLFPEVDAELATRDY
DESLTDKNIEKTFVNVAKPFHKERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGSDD
LQGKRVGLFSYGSGLAASLYSCKIVGDVQHIIKELDITNKLAKRITETPKDYEAAIEL
RENAHLKKNFKPQGSIEHLQSGVYYLTNIDDKFRRSYDVKK"
gene complement(<20761..>21699)
/gene="PGA3"
/locus_tag="YML125C"
/gene_synonym="NQR1"
/db_xref="GeneID:854914"
mRNA complement(<20761..>21699)
/gene="PGA3"
/locus_tag="YML125C"
/gene_synonym="NQR1"
/product="cytochrome-b5 reductase"
/transcript_id="NM_001182488.1"
/db_xref="GeneID:854914"
CDS complement(20761..21699)
/gene="PGA3"
/locus_tag="YML125C"
/gene_synonym="NQR1"
/EC_number="1.6.2.2"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:19239415]"
/experiment="EXISTENCE:mutant phenotype:GO:0004128
cytochrome-b5 reductase activity, acting on NAD(P)H
[PMID:19239415]"
/experiment="EXISTENCE:mutant phenotype:GO:0015031 protein
transport [PMID:16943325]"
/note="Putative cytochrome b5 reductase, localized to the
plasma membrane; may be involved in regulation of
lifespan; required for maturation of Gas1p and Pho8p,
proposed to be involved in protein trafficking; PGA3 has a
paralog, AIM33, that arose from the whole genome
duplication"
/codon_start=1
/product="cytochrome-b5 reductase"
/protein_id="NP_013581.1"
/db_xref="GeneID:854914"
/db_xref="SGD:S000004594"
/translation="MSKEDIEGTNILDEPVHGIYIPAALFVVGVAITTYMSGELKILW
SLPILFMIIFVRAYSAYKRRRSLYPDRWTSLELEDQTIISKNTALYRFKLKTRLESLD
IPAGHHVAVRVPIDGKQEVRYYNPISSKLESGYLDLVVKAYVDGKVSKYFAGLNSGDT
VDFKGPIGTLNYEPNSSKHLGIVAGGSGITPVLQILNEIITVPEDLTKVSLLYANETE
NDILLKDELDEMAEKYPHFQVHYVVHYPSDRWTGDVGYITKDQMNRYLPEYSEDNRLL
ICGPDGMNNLALQYAKELGWKVNSTRSSGDDQVFVF"
gene complement(<22048..>23683)
/gene="TUB3"
/locus_tag="YML124C"
/db_xref="GeneID:854915"
mRNA complement(join(<22048..23360,23659..>23683))
/gene="TUB3"
/locus_tag="YML124C"
/product="alpha-tubulin TUB3"
/transcript_id="NM_001182487.1"
/db_xref="GeneID:854915"
CDS complement(join(22048..23360,23659..23683))
/gene="TUB3"
/locus_tag="YML124C"
/experiment="EXISTENCE:curator inference:GO:0000070
mitotic sister chromatid segregation [PMID:3540600]"
/experiment="EXISTENCE:curator inference:GO:0030473
nuclear migration along microtubule [PMID:3540600]"
/experiment="EXISTENCE:curator inference:GO:0045143
homologous chromosome segregation [PMID:3540600]"
/experiment="EXISTENCE:direct assay:GO:0005819 spindle
[PMID:24390141]"
/experiment="EXISTENCE:genetic interaction:GO:0045298
tubulin complex [PMID:3540600]"
/experiment="EXISTENCE:mutant phenotype:GO:0005200
structural constituent of cytoskeleton [PMID:10793159]"
/note="Alpha-tubulin; associates with beta-tubulin (Tub2p)
to form tubulin dimer, which polymerizes to form
microtubules; expressed at lower level than Tub1p; TUB3
has a paralog, TUB1, that arose from the whole genome
duplication"
/codon_start=1
/product="alpha-tubulin TUB3"
/protein_id="NP_013582.1"
/db_xref="GeneID:854915"
/db_xref="SGD:S000004593"
/translation="MREVISINVGQAGCQIGNACWELYSLEHGIKEDGHLEDGLSKPK
GGEEGFSTFFHETGYGKFVPRAIYVDLEPNVIDEVRTGRFKELFHPEQLINGKEDAAN
NYARGHYTVGREIVDEVEERIRKMADQCDGLQGFLFTHSLGGGTGSGLGSLLLENLSY
EYGKKSKLEFAVYPAPQLSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAIYDICKRNL
GISRPSFSNLNGLIAQVISSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYAPI
LSKKRATHESNSVSEITNACFEPGNQMVKCDPTKGKYMANCLLYRGDVVTRDVQRAVE
QVKNKKTVQMVDWCPTGFKIGICYEPPSVIPSSELANVDRAVCMLSNTTAIADAWKRI
DQKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGADSYAEEF"
gene 23564..26578
/locus_tag="YNCM0001W"
/db_xref="GeneID:65052917"
ncRNA 23564..26578
/ncRNA_class="antisense_RNA"
/locus_tag="YNCM0001W"
/product="PHO84 lncRNA"
/note="Antisense to PHO84 and beginning of YML122C;
represses transcription of PHO84 through histone
deacetylation"
/transcript_id="NR_172477.1"
/db_xref="GeneID:65052917"
/db_xref="SGD:S000303814"
gene complement(<24037..>25800)
/gene="PHO84"
/locus_tag="YML123C"
/db_xref="GeneID:854916"
mRNA complement(<24037..>25800)
/gene="PHO84"
/locus_tag="YML123C"
/product="phosphate transporter PHO84"
/transcript_id="NM_001182486.1"
/db_xref="GeneID:854916"
CDS complement(24037..25800)
/gene="PHO84"
/locus_tag="YML123C"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005315 inorganic
phosphate transmembrane transporter activity
[PMID:7851439]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:2038328]"
/experiment="EXISTENCE:direct assay:GO:0006817 phosphate
ion transport [PMID:7851439]"
/experiment="EXISTENCE:direct assay:GO:0097079
selenite:proton symporter activity [PMID:20688911]"
/experiment="EXISTENCE:mutant phenotype:GO:0005315
inorganic phosphate transmembrane transporter activity
[PMID:2038328]"
/experiment="EXISTENCE:mutant phenotype:GO:0005384
manganese ion transmembrane transporter activity
[PMID:12923174]"
/experiment="EXISTENCE:mutant phenotype:GO:0006797
polyphosphate metabolic process [PMID:17804816]"
/experiment="EXISTENCE:mutant phenotype:GO:0006817
phosphate ion transport [PMID:2038328]"
/experiment="EXISTENCE:mutant phenotype:GO:0006828
manganese ion transport [PMID:12923174]"
/experiment="EXISTENCE:mutant phenotype:GO:0097079
selenite:proton symporter activity [PMID:20688911]"
/experiment="EXISTENCE:mutant phenotype:GO:0097080 plasma
membrane selenite transport [PMID:20688911]"
/note="High-affinity inorganic phosphate (Pi) transporter;
also low-affinity manganese transporter; regulated by
Pho4p and Spt7p; mutation confers resistance to arsenate;
exit from the ER during maturation requires Pho86p; cells
overexpressing Pho84p accumulate heavy metals but do not
develop symptoms of metal toxicity"
/codon_start=1
/product="phosphate transporter PHO84"
/protein_id="NP_013583.1"
/db_xref="GeneID:854916"
/db_xref="SGD:S000004592"
/translation="MSSVNKDTIHVAERSLHKEHLTEGGNMAFHNHLNDFAHIEDPLE
RRRLALESIDDEGFGWQQVKTISIAGVGFLTDSYDIFAINLGITMMSYVYWHGSMPGP
SQTLLKVSTSVGTVIGQFGFGTLADIVGRKRIYGMELIIMIVCTILQTTVAHSPAINF
VAVLTFYRIVMGIGIGGDYPLSSIITSEFATTKWRGAIMGAVFANQAWGQISGGIIAL
ILVAAYKGELEYANSGAECDARCQKACDQMWRILIGLGTVLGLACLYFRLTIPESPRY
QLDVNAKLELAAAAQEQDGEKKIHDTSDEDMAINGLERASTAVESLDNHPPKASFKDF
CRHFGQWKYGKILLGTAGSWFTLDVAFYGLSLNSAVILQTIGYAGSKNVYKKLYDTAV
GNLILICAGSLPGYWVSVFTVDIIGRKPIQLAGFIILTALFCVIGFAYHKLGDHGLLA
LYVICQFFQNFGPNTTTFIVPGECFPTRYRSTAHGISAASGKVGAIIAQTALGTLIDH
NCARDGKPTNCWLPHVMEIFALFMLLGIFTTLLIPETKRKTLEEINELYHDEIDPATL
NFRNKNNDIESSSPSQLQHEA"
gene complement(<26038..>26418)
/locus_tag="YML122C"
/db_xref="GeneID:854917"
mRNA complement(<26038..>26418)
/locus_tag="YML122C"
/product="uncharacterized protein"
/transcript_id="NM_001348863.1"
/db_xref="GeneID:854917"
CDS complement(26038..26418)
/locus_tag="YML122C"
/note="hypothetical protein; conserved among S. cerevisiae
strains; YML122C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335803.1"
/db_xref="GeneID:854917"
/db_xref="SGD:S000004591"
/translation="MPRNDSNQYYARWCCYRRPIRAAFARKGPFNSSSGYEENVARLK
NTRSSHCRTARCQFNSSTWTCYFQHVGRKLATAIDYGSPQSIEISEIGAVMHQMSCER
LSLSLFSRFACLLARLKTCVLLIN"
gene <26930..>27862
/gene="GTR1"
/locus_tag="YML121W"
/db_xref="GeneID:854918"
mRNA <26930..>27862
/gene="GTR1"
/locus_tag="YML121W"
/product="Rag GTPase GTR1"
/transcript_id="NM_001182484.1"
/db_xref="GeneID:854918"
CDS 26930..27862
/gene="GTR1"
/locus_tag="YML121W"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane
[PMID:15885099|PMID:19748353|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0003924 GTPase
activity [PMID:22726655|PMID:23716719]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10388807]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10388807]"
/experiment="EXISTENCE:direct assay:GO:0031902 late
endosome membrane [PMID:16732272]"
/experiment="EXISTENCE:direct assay:GO:0071986 Ragulator
complex [PMID:16732272]"
/experiment="EXISTENCE:direct assay:GO:1904263 positive
regulation of TORC1 signaling [PMID:19748353]"
/experiment="EXISTENCE:genetic interaction:GO:0010507
negative regulation of autophagy [PMID:25046117]"
/experiment="EXISTENCE:genetic interaction:GO:1904263
positive regulation of TORC1 signaling [PMID:19748353]"
/experiment="EXISTENCE:mutant phenotype:GO:0006360
transcription by RNA polymerase I [PMID:15937128]"
/experiment="EXISTENCE:mutant phenotype:GO:0006383
transcription by RNA polymerase III [PMID:15937128]"
/experiment="EXISTENCE:mutant phenotype:GO:0006817
phosphate ion transport [PMID:1620108]"
/experiment="EXISTENCE:mutant phenotype:GO:0010507
negative regulation of autophagy [PMID:25046117]"
/experiment="EXISTENCE:mutant phenotype:GO:0031509
subtelomeric heterochromatin formation [PMID:18258182]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress [PMID:35158208]"
/experiment="EXISTENCE:mutant phenotype:GO:1903778 protein
localization to vacuolar membrane [PMID:25046117]"
/experiment="EXISTENCE:mutant phenotype:GO:1904263
positive regulation of TORC1 signaling
[PMID:19748353|PMID:26387955]"
/experiment="EXISTENCE:physical interaction:GO:0006360
transcription by RNA polymerase I [PMID:15937128]"
/experiment="EXISTENCE:physical interaction:GO:0006383
transcription by RNA polymerase III [PMID:15937128]"
/experiment="EXISTENCE:physical interaction:GO:1990131
Gtr1-Gtr2 GTPase complex [PMID:10388807|PMID:16143306]"
/note="Subunit of TORC1-stimulating GTPase and EGO/GSE
complex; subunit of Gtr1-Gtr2 GTPase that activates TORC1
in response to amino acid stimulation; subunit of EGO/GSE
vacuolar membrane complex that regulates exit from
rapamycin-induced growth arrest and sorting of Gap1p;
involved in phosphate transport, telomeric chromatin
silencing and oxidative stress response; activated by
Iml1p (GAP) subunit of SEACIT complex; targeted to vacuole
via AP-3 pathway; similar to human RagA and RagB"
/codon_start=1
/product="Rag GTPase GTR1"
/protein_id="NP_013585.1"
/db_xref="GeneID:854918"
/db_xref="SGD:S000004590"
/translation="MSSNNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDV
EHSHLRFLGNMTLNLWDCGGQDVFMENYFTKQKDHIFQMVQVLIHVFDVESTEVLKDI
EIFAKALKQLRKYSPDAKIFVLLHKMDLVQLDKREELFQIMMKNLSETSSEFGFPNLI
GFPTSIWDESLYKAWSQIVCSLIPNMSNHQSNLKKFKEIMNALEIILFERTTFLVICS
SNGENSNENHDSSDNNNVLLDPKRFEKISNIMKNFKQSCTKLKSGFKTLILNNNIYVS
ELSSNMVCFIVLKDMNIPQELVLENIKKAKEFFQ"
gene complement(<28266..>29807)
/gene="NDI1"
/locus_tag="YML120C"
/db_xref="GeneID:854919"
mRNA complement(<28266..>29807)
/gene="NDI1"
/locus_tag="YML120C"
/product="NADH-ubiquinone reductase (H(+)-translocating)
NDI1"
/transcript_id="NM_001182483.1"
/db_xref="GeneID:854919"
CDS complement(28266..29807)
/gene="NDI1"
/locus_tag="YML120C"
/EC_number="1.6.5.9"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:1900238]"
/experiment="EXISTENCE:direct assay:GO:0006116 NADH
oxidation [PMID:3138118]"
/experiment="EXISTENCE:direct assay:GO:0006120
mitochondrial electron transport, NADH to ubiquinone
[PMID:1900238]"
/experiment="EXISTENCE:direct assay:GO:0008137 NADH
dehydrogenase (ubiquinone) activity [PMID:3138118]"
/experiment="EXISTENCE:mutant phenotype:GO:0005759
mitochondrial matrix [PMID:1900238]"
/experiment="EXISTENCE:mutant phenotype:GO:0043065
positive regulation of apoptotic process [PMID:16436509]"
/note="NADH:ubiquinone oxidoreductase; transfers electrons
from NADH to ubiquinone in respiratory chain but does not
pump protons, in contrast to higher eukaryotic
multisubunit respiratory complex I; upon apoptotic stress,
is activated in mitochondria by N-terminal cleavage, then
translocates to cytoplasm to induce apoptosis; homolog of
human AIFM2; yeast NDI1 complements several phenotypes of
human cell line with mutated MT-ND4, implicated in Leber
hereditary optic neuropathy"
/codon_start=1
/product="NADH-ubiquinone reductase (H(+)-translocating)
NDI1"
/protein_id="NP_013586.1"
/db_xref="GeneID:854919"
/db_xref="SGD:S000004589"
/translation="MLSKNLYSNKRLLTSTNTLVRFASTRSTGVENSGAGPTSFKTMK
VIDPQHSDKPNVLILGSGWGAISFLKHIDTKKYNVSIISPRSYFLFTPLLPSAPVGTV
DEKSIIEPIVNFALKKKGNVTYYEAEATSINPDRNTVTIKSLSAVSQLYQPENHLGLH
QAEPAEIKYDYLISAVGAEPNTFGIPGVTDYGHFLKEIPNSLEIRRTFAANLEKANLL
PKGDPERRRLLSIVVVGGGPTGVEAAGELQDYVHQDLRKFLPALAEEVQIHLVEALPI
VLNMFEKKLSSYAQSHLENTSIKVHLRTAVAKVEEKQLLAKTKHEDGKITEETIPYGT
LIWATGNKARPVITDLFKKIPEQNSSKRGLAVNDFLQVKGSNNIFAIGDNAFAGLPPT
AQVAHQEAEYLAKNFDKMAQIPNFQKNLSSRKDKIDLLFEENNFKPFKYNDLGALAYL
GSERAIATIRSGKRTFYTGGGLMTFYLWRILYLSMILSARSRLKVFFDWIKLAFFKRD
FFKGL"
gene <30611..>31684
/locus_tag="YML119W"
/db_xref="GeneID:854920"
mRNA <30611..>31684
/locus_tag="YML119W"
/product="uncharacterized protein"
/transcript_id="NM_001182482.1"
/db_xref="GeneID:854920"
CDS 30611..31684
/locus_tag="YML119W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:24390141]"
/note="hypothetical protein; YML119W is not an essential
gene; potential Cdc28p substrate"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013587.1"
/db_xref="GeneID:854920"
/db_xref="SGD:S000004588"
/translation="MSPSPSVSPRRTLNNKSSYINNSGGLVLPPTQFNLNQQPVLSFQ
QKATFDSNQQFFYYPESPTKNLRPRFNSISQVNKGVNEDHYTGGGSSNNNRPSRYTNT
MGAANTNVNSHPHHQSVSHLNSKSLKFNQTKEVSSINEIIFPSRTCTKKRYFTKPIDL
YGTRSSTSVAPKLTNSPTKSKTNFNIKKCILPRSVVTTYKLPSPVHETIDDISKKIII
LLISLKFEKNYHFLQPIQLSTNSKTRISKSLDELCGVQLTSTLRQQKQLQGNSKPVKN
LPNSNAKQRAGASVSTNANESFELSFDGKAMDRSDIFRMVDSFSIAISDEDEEDEEED
SFQQRSANNRILPAEILSNEPLK"
rep_origin 31766..31835
/note="ARS1303; Autonomously Replicating Sequence"
/db_xref="SGD:S000118365"
gene <32334..>33851
/gene="NGL3"
/locus_tag="YML118W"
/db_xref="GeneID:854921"
mRNA <32334..>33851
/gene="NGL3"
/locus_tag="YML118W"
/product="3'-5' poly(A) RNA exonuclease"
/transcript_id="NM_001182481.1"
/db_xref="GeneID:854921"
CDS 32334..33851
/gene="NGL3"
/locus_tag="YML118W"
/experiment="EXISTENCE:direct assay:GO:0004535
poly(A)-specific ribonuclease activity [PMID:21965533]"
/experiment="EXISTENCE:direct assay:GO:0043633
polyadenylation-dependent RNA catabolic process
[PMID:21965533]"
/note="3'-5' exonuclease specific for poly-A RNAs; has a
domain similar to a magnesium-dependent endonuclease motif
in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a
paralog, NGL2, that arose from the whole genome
duplication"
/codon_start=1
/product="3'-5' poly(A) RNA exonuclease"
/protein_id="NP_013588.1"
/db_xref="GeneID:854921"
/db_xref="SGD:S000004587"
/translation="MDSQVEGKISPSQKESSSTSGLVSPSEDGPAHQKIHRDQLSVDQ
IKKIREERAQKRQVRRNSLISQGKDPDFPTPDLQFIERPFLPINHDNSKGLTPATIQV
TQDSLDVKIMTYNTLAQTLIRRDFFPESGPALKWHKRSKVLVHELKKYRPDVVSLQEV
DYNELNFWQENFHKLGFDVIFKRHEGKTHGLLVAWNNKKFQLDNDWMLDYDNILAGNV
ISARTRTKNIALIISLYFKGITDSSSRGIIVANTHLFWHPFGVFERLRQSYLVLQKIQ
EIKACSKYNGWHSLLMGDFNTEPEEPPYLAITKRPLILKGPIRAMVECSLAYRYSKKR
NGEESDQDDEECDEKSRGEGHSDQPQNPKPESFTATKEEKALVNQLVALHNSLHVKGV
SLYGIGYGKVHPENANGSHGEPGLSNWANTWCGLLDYIFYIEGDHNQDTRQKEPLNAF
EGNNNVKIIGYLRMPCAQEMPKHSQPFEGEYASDHISLMCQIRLFFGGEKVHSLK"
gene <34243..>37647
/gene="NAB6"
/locus_tag="YML117W"
/db_xref="GeneID:854922"
mRNA <34243..>37647
/gene="NAB6"
/locus_tag="YML117W"
/product="Nab6p"
/transcript_id="NM_001182479.1"
/db_xref="GeneID:854922"
CDS 34243..37647
/gene="NAB6"
/locus_tag="YML117W"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR
binding [PMID:36862555]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:23222640|PMID:26777405]"
/experiment="EXISTENCE:genetic interaction:GO:0070935
3'-UTR-mediated mRNA stabilization [PMID:36862555]"
/experiment="EXISTENCE:genetic interaction:GO:1990394
cellular response to cell wall damage [PMID:36862555]"
/experiment="EXISTENCE:mutant phenotype:GO:0070935
3'-UTR-mediated mRNA stabilization [PMID:36862555]"
/experiment="EXISTENCE:mutant phenotype:GO:1990394
cellular response to cell wall damage [PMID:36862555]"
/note="mRNA-binding protein; binds to the 3'UTR of cell
wall-related mRNAs and stabilizes these mRNAs, acting in
parallel to cell wall integrity signaling to maintain
expression of cell wall genes during stress; acts
antagonistically to Nab6p; deletion mutants display
increased sensitivity to some cell wall disrupting agents;
expression negatively regulated by cAMP"
/codon_start=1
/product="Nab6p"
/protein_id="NP_013589.1"
/db_xref="GeneID:854922"
/db_xref="SGD:S000004585"
/translation="MSNSNSKKPVANYAYRQQQDYNGMNAMVGNPMMYHPVDFVNGAG
QYGPSQHPAYYTNSPLPNIPPTPFDTAYGASLFPSHLLMGSPFVSSPNMQSGYNSARS
SNLKRKAYSRPVSNHNGYNGNSNSNQNNTNNGMVTPSNYYRMGRNSFSRNNNSTRNVT
HNNNKGCDTRNNSGRRTFARNNIFDDILPEMLLQRPFCINYKVLPTGDDAYRTRSLLI
ENVDHSIDLHSIVKNFVKSNTLESAYLIEGGKSDDSKDVETKNLSILISFLTKGDCLN
FYNNILQRLSEFKTFLKSEALNLKFVCLNYDPKCLPTFIESEALTENAEEADITNGST
MISASLHHNIANKDATRSIIIEFKSPVEKSDLFKKKLQFLDRSKNKRYILESIDLVNT
DVPSNQFPENYAVLTFLNISMAIEVLDYLKKYSKNLGISKCFYVSLAPLVVSSARSSV
ANIYEGKTSTHRLSVPSVTAGNNNDSNNNGNNNKSNMSGITTLNNNSSIGVSVYGHSN
MSLTSLSSSVSLNEEIDMLATKLQGVELDGTYLEINYRDYQTPTIEEHSTHLSNVKIS
KTTENSRQFSQDIPSPLPLNEHMFMNDSNQSNGAIIPQQLIATPSPVSPNLQMNQRVL
PNPITQSLEQNFNVSAKVASSMGSDIGNRTIYIGNINPRSKAEDICNVVRGGILQSIK
YIPEKKICFVTFIEAPSAVQFYANSFIDPIVLHGNMLRVGWGHYSGPLPKLISLAVTI
GASRNVYVSLPEFAFKEKFIHDPQYKKLHETLSLPDAEQLREDFSTYGDIEQINYLSD
SHCCWINFMNISSAISLVEEMNKESTVQNESGEVTLKRATEEKFGGRYKGLLINYGKD
RCGNINKNLIAGKNSRFYKKVKRPSYNIRLSKLEEKRRQNEIDEKEKAFDKPLNLESL
GISLDAHKDNGGGETGTANNTGHENESELEAENENGNETGSFGGLGLAVASSDVKRAT
SDETDYEDIFNKSSGSSDSSSDVEVIMHSPSDPEYALKSQTLRSSSQTVINSKRPVKI
EDEEEAVGMSQLNYRSSLRQAPPRAPSTLSYNHSKNNETPMQDIFTNGETANNRKKKR
GSFARHRTIPGSDVMAQYLAQVQHSTFMYAANILGASAEDNTHPDE"
gene <38196..>39824
/gene="ATR1"
/locus_tag="YML116W"
/gene_synonym="SNQ1"
/db_xref="GeneID:854924"
mRNA <38196..>39824
/gene="ATR1"
/locus_tag="YML116W"
/gene_synonym="SNQ1"
/product="borate transporter"
/transcript_id="NM_001182478.1"
/db_xref="GeneID:854924"
CDS 38196..39824
/gene="ATR1"
/locus_tag="YML116W"
/gene_synonym="SNQ1"
/experiment="EXISTENCE:direct assay:GO:0005773 vacuole
[PMID:19414602]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:19414602]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma
membrane [PMID:2123132]"
/experiment="EXISTENCE:mutant phenotype:GO:0046713 borate
transport [PMID:19414602]"
/experiment="EXISTENCE:mutant phenotype:GO:0080139 borate
efflux transmembrane transporter activity [PMID:19414602]"
/note="Multidrug efflux pump of the major facilitator
superfamily; required for resistance to aminotriazole and
4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C,
that arose from the whole genome duplication; protein
abundance increases in response to DNA replication stress"
/codon_start=1
/product="borate transporter"
/protein_id="NP_013591.1"
/db_xref="GeneID:854924"
/db_xref="SGD:S000004584"
/translation="MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQ
SEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS
EGNSKSWLMASFPLVSGSFILISGRLGDIYGLKKMLLVGYVLVIIWSLICGITKYSGS
DTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGATLGCLF
AGLIGTEDPKQWPWAFYAYSIAAFINFVLSIYAIPSTIPTNIHHFSMDWIGSVLGVIG
LILLNFVWNQAPISGWNQAYIIVILIISVIFLVVFIIYEIRFAKTPLLPRAVIKDRHM
IQIMLALFFGWGSFGIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGIIAALLVGFTI
KNVSPSVFLFFSMVAFNVGSIMASVTPVHETYFRTQLGTMIILSFGMDLSFPASSIIF
SDNLPMEYQGMAGSLVNTVVNYSMSLCLGMGATVETQVNSDGKHLLKGYRGAQYLGIG
LASLACMISGLYMVESFIKGRRARAAAEYDCTVA"
rep_origin 39824..40187
/note="ARS1304; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130187"
gene complement(<40187..>41794)
/gene="VAN1"
/locus_tag="YML115C"
/gene_synonym="LDB13; VRG7; VRG8"
/db_xref="GeneID:854925"
mRNA complement(<40187..>41794)
/gene="VAN1"
/locus_tag="YML115C"
/gene_synonym="LDB13; VRG7; VRG8"
/product="Van1p"
/transcript_id="NM_001182477.1"
/db_xref="GeneID:854925"
CDS complement(40187..41794)
/gene="VAN1"
/locus_tag="YML115C"
/gene_synonym="LDB13; VRG7; VRG8"
/experiment="EXISTENCE:direct assay:GO:0000009
alpha-1,6-mannosyltransferase activity [PMID:12235155]"
/experiment="EXISTENCE:direct assay:GO:0000136 mannan
polymerase complex [PMID:9430634]"
/experiment="EXISTENCE:direct assay:GO:0006487 protein
N-linked glycosylation [PMID:9430634]"
/experiment="EXISTENCE:mutant phenotype:GO:0000032 cell
wall mannoprotein biosynthetic process [PMID:12235155]"
/experiment="EXISTENCE:mutant phenotype:GO:0006487 protein
N-linked glycosylation [PMID:9430634]"
/note="Component of the mannan polymerase I; complex
contains Van1p and Mnn9p and is involved in the first
steps of mannan synthesis; mutants are vanadate-resistant"
/codon_start=1
/product="Van1p"
/protein_id="NP_013592.1"
/db_xref="GeneID:854925"
/db_xref="SGD:S000004583"
/translation="MGMFFNLRSNIKKKAMDNGLSLPISRNGSSNNIKDKRSEHNSNS
LKGKYRYQPRSTPSKFQLTVSITSLIIIAVLSLYLFISFLSGMGIGVSTQNGRSLLGS
SKSSENYKTIDLEDEEYYDYDFEDIDPEVISKFDDGVQHYLISQFGSEVLTPKDDEKY
QRELNMLFDSTVEEYDLSNFEGAPNGLETRDHILLCIPLRNAADVLPLMFKHLMNLTY
PHELIDLAFLVSDCSEGDTTLDALIAYSRHLQNGTLSQIFQEIDAVIDSQTKGTDKLY
LKYMDEGYINRVHQAFSPPFHENYDKPFRSVQIFQKDFGQVIGQGFSDRHAVKVQGIR
RKLMGRARNWLTANALKPYHSWVYWRDADVELCPGSVIQDLMSKNYDVIVPNVWRPLP
TFLGTEQPYDLNSWMESQEALALAKTLDEDDVIVEGYAEYPTWRVHLAYIRDAEGDPN
EAVDLDGVGGVSILAKAKIFRNGVQFPAFTFENHAETEAFGKMAKKMGYRVGGLPHYT
IWHIYEPSDDDLKEIASREREKRRQSE"
gene complement(<42043..>43575)
/gene="TAF8"
/locus_tag="YML114C"
/gene_synonym="TAF65"
/db_xref="GeneID:854926"
mRNA complement(<42043..>43575)
/gene="TAF8"
/locus_tag="YML114C"
/gene_synonym="TAF65"
/product="Taf8p"
/transcript_id="NM_001182476.1"
/db_xref="GeneID:854926"
CDS complement(42043..43575)
/gene="TAF8"
/locus_tag="YML114C"
/gene_synonym="TAF65"
/experiment="EXISTENCE:curator inference:GO:0016251 RNA
polymerase II general transcription initiation factor
activity [PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005669
transcription factor TFIID complex
[PMID:10788514|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0006366
transcription by RNA polymerase II
[PMID:12138208|PMID:15448131]"
/note="TFIID subunit (65 kDa); involved in RNA polymerase
II transcription initiation"
/codon_start=1
/product="Taf8p"
/protein_id="NP_013593.1"
/db_xref="GeneID:854926"
/db_xref="SGD:S000004582"
/translation="MTSKTSESGTGTQSTIVQLRNLPDLTEISHLEIDAPVVEILKKT
VLFQLNSLNICISNFALDELVNLVTVQMDGMFRNLHNLTLLQRRSQASQADLKLLLRE
FNLDAPSLYQQFQASEFIKSKHSTEYEKLMSWSSLAALPHNEEDEEDELNNIEEQQNE
INVLLPPSNPLEKQIPSWLPNFPPDHTYKFTPEFNHPITDLKTIKKEIVKESQESEKA
LLNLNKSLSHISSASNTPQPPGLDDEDAIEQQLEIWGNALEERKPTITEKSFNENNIE
QYAKYRVELARERVTKFEVNQLKRTKNPFLKISETLYLPESPHQSHKTIQKTIELQFR
KSMTLFMHNLPKVQKLKKEKIRMAKEERAKSLKRRQEELISQRTKREQDEGHDLELLL
NNEHARDAADDTTTPNALNNSTIVINTNAEDEDDDINLFGILGSSEDENEMSSMPAEN
LVAESEPPTMTAQDTTNTTPVAHNTTNIDATTSHSPHSTPNENAPTSPPADIATDHDI
TM"
gene <44045..>44791
/gene="DAT1"
/locus_tag="YML113W"
/db_xref="GeneID:854927"
mRNA <44045..>44791
/gene="DAT1"
/locus_tag="YML113W"
/product="Dat1p"
/transcript_id="NM_001182475.1"
/db_xref="GeneID:854927"
CDS 44045..44791
/gene="DAT1"
/locus_tag="YML113W"
/experiment="EXISTENCE:direct assay:GO:0003680 minor
groove of adenine-thymine-rich DNA binding [PMID:2670564]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:mutant phenotype:GO:0000122
negative regulation of transcription by RNA polymerase II
[PMID:8248247]"
/note="DNA binding protein that recognizes
oligo(dA).oligo(dT) tracts; Arg side chain in its
N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required
for DNA-binding; relocalizes to the cytosol in response to
hypoxia; not essential for viability"
/codon_start=1
/product="Dat1p"
/protein_id="NP_013594.1"
/db_xref="GeneID:854927"
/db_xref="SGD:S000004581"
/translation="MAKTLAQGRKPGSGRKPGKGKTLREGRKPGSGRRRRQDTGGKET
DGSQQDQESRLISSRDMEAVDALRELTHSPSSHSAHNSSAAPPPHAAAASTSLPPSLD
YTHQSFMDQQQQQQQQQQQQLLQQQRVDVVPPKPFITHKILLSSTGNSGGHVNSNYNA
DHSINHNSNHNLNSNVNVNMNFTINGSNQDPSSSFLMGPYNYLQRPFIVKPYLDLSTS
TAASNQPRTQPSPAAHITKNSDSTEKNATI"
gene <45063..>45953
/gene="CTK3"
/locus_tag="YML112W"
/db_xref="GeneID:854928"
mRNA <45063..>45953
/gene="CTK3"
/locus_tag="YML112W"
/product="Ctk3p"
/transcript_id="NM_001182474.1"
/db_xref="GeneID:854928"
CDS 45063..45953
/gene="CTK3"
/locus_tag="YML112W"
/experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm
[PMID:15520468]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:15520468]"
/experiment="EXISTENCE:direct assay:GO:0016538
cyclin-dependent protein serine/threonine kinase regulator
activity [PMID:11118453]"
/experiment="EXISTENCE:direct assay:GO:0032786 positive
regulation of DNA-templated transcription, elongation
[PMID:9110987]"
/experiment="EXISTENCE:direct assay:GO:0070692 CTDK-1
complex [PMID:7565723]"
/experiment="EXISTENCE:mutant phenotype:GO:0045943
positive regulation of transcription by RNA polymerase I
[PMID:15520468]"
/experiment="EXISTENCE:physical interaction:GO:0045903
positive regulation of translational fidelity
[PMID:17545469]"
/note="Gamma subunit of C-terminal domain kinase I; CTDK-I
phosphorylates RNA polymerase II subunit Rpo21p to affect
transcription and pre-mRNA 3' end processing, and also
phosphorylates ribosomal protein Rps2p to increase
translational fidelity; protein abundance increases in
response to DNA replication stress"
/codon_start=1
/product="Ctk3p"
/protein_id="NP_013595.1"
/db_xref="GeneID:854928"
/db_xref="SGD:S000004580"
/translation="MDSLEARLQFIQVLKNLQKTLHKTRDSITSSSTTTPPSSQQKLN
NDPIQFYLRNYRHHYEDFHQCLFDTTMKMDPLDRLDVVIYYVRIIRNLYPHSHSNTNV
TKVLNEVLLMDIDLVFELCLPCQDWKSLTNQATCKELFLDLSKLIHYDATSVTHTPSD
TTLIDATTWYSVKTERTTKDYKESLQRTESLLKDRDLKKLAFFQQFNSDTTAINPDLQ
TQPTNANILLHRMEADRELHKRSKETSWYIERPSNDILDESEFKSLWTHFETTDSGFD
KDDYKNIKALNDIAKASYIY"
gene <46942..>49704
/gene="BUL2"
/locus_tag="YML111W"
/db_xref="GeneID:854929"
mRNA <46942..>49704
/gene="BUL2"
/locus_tag="YML111W"
/product="ubiquitin-ubiquitin ligase BUL2"
/transcript_id="NM_001182473.1"
/db_xref="GeneID:854929"
CDS 46942..49704
/gene="BUL2"
/locus_tag="YML111W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0034450
ubiquitin-ubiquitin ligase activity [PMID:11352928]"
/experiment="EXISTENCE:mutant phenotype:GO:0000151
ubiquitin ligase complex [PMID:11352928]"
/experiment="EXISTENCE:mutant phenotype:GO:0000209 protein
polyubiquitination [PMID:9931424]"
/experiment="EXISTENCE:mutant phenotype:GO:0006513 protein
monoubiquitination [PMID:9931424]"
/note="Alpha-arrestin, component of the Rsp5p E3-ubiquitin
ligase complex; ubiquitin-binding adaptor involved in
intracellular amino acid permease sorting, functions in
heat shock element mediated gene expression, essential for
growth in stress conditions; BUL2 has a paralog, BUL1,
that arose from the whole genome duplication"
/codon_start=1
/product="ubiquitin-ubiquitin ligase BUL2"
/protein_id="NP_013596.1"
/db_xref="GeneID:854929"
/db_xref="SGD:S000004579"
/translation="MTFTFSTSSRKNGRPPLKSVSTEDNIHLLRKRRQQQLSSNSTDN
SLHPNSGQTPRASDSQDDDIRSASTTNLDRLRQEREENSLEMDCTQSRLSHRANMLVD
VLPSFEMYNALHRHIPQGNVDPDRHDFPPSYQEVRTQRMTILPSNDNSVERSQLTAVP
GSENACNNATAHSLTNLHPLQTQHLTINSTRSGGQSLHSSSDTNISQIPFEDDLNDSD
NIFIDKLYTLPKLSTPIEIDIRITKTASIPHERPEEQSILKEYTSGDIIHGYCLIENR
SSQPLKFEMFYVTLEAYISVIDRQKGKRTLKRFLRMVDLSASWSYTNITPSTGINIVP
GERDFDDAIIGLSNSRELKPNTKYKKFFMFKLPTQLLDVTCKQEQFSHCLLPPSFGID
KYKNNCKYSGIKVNSVLGCGHLGTKGSPILTLDMADDNLSINYTIDAKIVGKDKRTSK
LNIMKEKEYNLRVMPFPFAGVTNQQNEKTCLRQLKNLESLIEDRFEALNKIFKKLELN
EAISNVDIHDTDISGTLDGNEDLDSDEILRRKLDQLHINNRIDDTASQSPSYDSKNMA
PKENLVETELRYKFKNKNKSNSSLFSHFLSSSETGSSSTGPHVYNSGLIVLSVKKPQS
TLPYWSPSLLRKTNKFEAKSEQEKENWQRLMGMLPEGVKTPLTKLDVHLTCIQSNNSA
GHKPPEISSVTTEFVVITAKSDNSIPIKFCTELLMNENRLNKLKTKFLTYQKKVHEYR
KKFEENHAKLNELYNRNRDHFTPKELLFTNFISDQINNDIDSLAGLKVNIIDLHDIFK
KQIHTFEEENEDIISKKGSSNPPSASSSNNNFLQATFSNGASTATKFTQQIVHEWEKV
KPLQYKRDVTVNLKLNPNIKETLVPNLETCLCCRFYCVRVNIKFDNHLGSMKVDIPVD
VKKLQI"
gene complement(<50031..>50954)
/gene="COQ5"
/locus_tag="YML110C"
/gene_synonym="DBI56"
/db_xref="GeneID:854930"
mRNA complement(<50031..>50954)
/gene="COQ5"
/locus_tag="YML110C"
/gene_synonym="DBI56"
/product="2-hexaprenyl-6-methoxy-1,4-benzoquinone
methyltransferase"
/transcript_id="NM_001182472.1"
/db_xref="GeneID:854930"
CDS complement(50031..50954)
/gene="COQ5"
/locus_tag="YML110C"
/gene_synonym="DBI56"
/EC_number="2.1.1.201"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:9083048]"
/experiment="EXISTENCE:mutant phenotype:GO:0006744
ubiquinone biosynthetic process [PMID:9083048]"
/experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
respiration [PMID:9083049]"
/experiment="EXISTENCE:mutant phenotype:GO:0043334
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
activity [PMID:9083049]"
/note="2-hexaprenyl-6-methoxy-1,4-benzoquinone
methyltransferase; involved in ubiquinone (Coenzyme Q)
biosynthesis; localizes to the matrix face of the
mitochondrial inner membrane in a large complex with other
ubiquinone biosynthetic enzymes; respiratory defect of the
null mutant is partially complemented by human COQ5"
/codon_start=1
/product="2-hexaprenyl-6-methoxy-1,4-benzoquinone
methyltransferase"
/protein_id="NP_013597.1"
/db_xref="GeneID:854930"
/db_xref="SGD:S000004578"
/translation="MLISSRIVRSSLVNVPLRLSRCFTQAHRACKEEEVNSPLSSAAE
QPEQKYTHFGSKTVLKSTKQKLVGDVFSSVANRYDLMNDVMSLGIHRLWKDHFINKLD
AGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAESKFGDTESTMDIVDINPDMLKEGEKR
AMEQGKYFKDPRVRFLVSNGEKLEEIDSDSKDIYTVSFGIRNFTDIQKGLNTAYRVLK
PGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIANDYDSYQYLVESIERFPDQET
FKSMIEKAGFKSAGYESLTFGICAIHWGIKV"
gene <51640..>54468
/gene="ZDS2"
/locus_tag="YML109W"
/gene_synonym="CES4"
/db_xref="GeneID:854931"
mRNA <51640..>54468
/gene="ZDS2"
/locus_tag="YML109W"
/gene_synonym="CES4"
/product="Zds2p"
/transcript_id="NM_001182471.1"
/db_xref="GeneID:854931"
CDS 51640..54468
/gene="ZDS2"
/locus_tag="YML109W"
/gene_synonym="CES4"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:21536748]"
/experiment="EXISTENCE:direct assay:GO:0005934 cellular
bud tip [PMID:20980617]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:21536748]"
/experiment="EXISTENCE:genetic interaction:GO:0010971
positive regulation of G2/M transition of mitotic cell
cycle [PMID:20980617]"
/experiment="EXISTENCE:genetic interaction:GO:0030010
establishment of cell polarity [PMID:8816439]"
/experiment="EXISTENCE:genetic interaction:GO:0032880
regulation of protein localization [PMID:18762578]"
/experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA
heterochromatin formation [PMID:10662670]"
/experiment="EXISTENCE:mutant phenotype:GO:0010971
positive regulation of G2/M transition of mitotic cell
cycle [PMID:21536748]"
/note="Protein with a role in regulating Swe1p-dependent
polarized growth; involved in maintenance of Cdc55p in the
cytoplasm where it promotes mitotic entry; interacts with
silencing proteins at the telomere; implicated in the
mitotic exit network through regulation of Cdc14p
localization; ZDS2 has a paralog, ZDS1, that arose from
the whole genome duplication"
/codon_start=1
/product="Zds2p"
/protein_id="NP_013598.1"
/db_xref="GeneID:854931"
/db_xref="SGD:S000004577"
/translation="MVLMEDMQNKDGHNTVENSSGGTDSNNNIQMRRMRKTQLSKKEL
FEKRKSDVLIAAKSLDTEIQNVKNLKRLSIGSMDLVIDPELEFKVNSRNSYSSDSSKE
SLQESLHEENIIRSEQKEEQGSEDNDAYEEGDATNVDDSIDITQTEYLHDEETLEKEK
IIRNASSSTSSSARVTSRNRRLSGVKTLAHDVVLDVENDHDSKMVDLTQNLLWVPADQ
HPNVKPENYLELIQDTLQNIQISTNQDIDENKLELGNNHVISNRKRTGSVVRRPSRLK
TSYTKFDDEPPLADKPQEGEIQVDKRISSSDIKTIRSVSLKEITEELTKISNNAGLTD
SDAVTLARSLSMSGSFTNESLHLNGNHTENDNEFASNMFNETGLTIPERSSLRRSKFN
TYKIRLEGSSLPQAVKLNSLMNIQTNDNRRSASSPASYTQVPQEQASLNDFHEIFDHY
RRTSTDWSTENEKYVDSTNYYSDEEDLTHASISQESSLLSTDSSNNSVLIKPHNTGSM
ISEKLDQHVSSSEKSNTNNSEANHGWSWLNSSNGSLNANEQTYQQLTDDEDDEECVDN
EKADFVNLSVSRRAKSTKRASERINHSKNRHSPIFQIHSEEAKSVVITPSVVSSSESQ
PSKPTAPAVVEKKVELPTDTQASTHKKNSLEKRLAKLFKRKQHNGTCKSDVKVIKKSV
KKELKKKASHSSLSKFRKSPKKKPQEAEVERPSSPTKTITTEDIDTASVIEPEVRSSN
ASTLLPDSHTSHSSEFVVETISELDGDDSFDISGGDVNYDVEVHSSISRDTTAGLEED
IGAEREDNTSPTAPQISTLPPRKLTFEDVVKPDYSNAPIKFTDSAFGFPLPMITNSTV
IMFDHRLGINVERAIYRLSHLKLSDPGRELRQQVLLSNFMYSYLNLVNHTLYMEQVGT
GDIAFNGDSALGMMDKNDSDGTILIPDI"
gene <54793..>55110
/locus_tag="YML108W"
/db_xref="GeneID:854863"
mRNA <54793..>55110
/locus_tag="YML108W"
/product="uncharacterized protein"
/transcript_id="NM_001182470.1"
/db_xref="GeneID:854863"
CDS 54793..55110
/locus_tag="YML108W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:22842922]"
/note="hypothetical protein; structure defines a new
subfamily of the split beta-alpha-beta sandwiches; green
fluorescent protein (GFP)-fusion protein localizes to the
cytoplasm and nucleus; YML108W is not an essential gene;
relative distribution to the nucleus increases upon DNA
replication stress"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013599.1"
/db_xref="GeneID:854863"
/db_xref="SGD:S000004576"
/translation="MSKSNTYRMLVLLEDDTKINKEDEKFLKGKPGKMHEFVDELILP
FNVDELDELNTWFDKFDAEICIPNEGHIKYEISSDGLIVLMLDKEIEEVVEKVKKFVE
ENN"
gene complement(<55265..>56269)
/gene="PML39"
/locus_tag="YML107C"
/db_xref="GeneID:854864"
mRNA complement(<55265..>56269)
/gene="PML39"
/locus_tag="YML107C"
/product="Pml39p"
/transcript_id="NM_001182469.1"
/db_xref="GeneID:854864"
CDS complement(55265..56269)
/gene="PML39"
/locus_tag="YML107C"
/experiment="EXISTENCE:direct assay:GO:0031965 nuclear
membrane [PMID:16162818]"
/experiment="EXISTENCE:direct assay:GO:0044615 nuclear
pore nuclear basket [PMID:36857168]"
/experiment="EXISTENCE:mutant phenotype:GO:0051237
maintenance of RNA location [PMID:16162818]"
/note="Protein required for nuclear retention of unspliced
pre-mRNAs; required along with Mlp1p and Pml1p; anchored
to the nuclear pore complex through an interaction between
its bimodular nuclear basket-interaction domain (NuBaID)
and Mlp1p and Mlp2p; localizes to the nuclear basket
enables linkage between subpopulations of Mlp1p;
associates with the subset of nuclear pores farthest from
the nucleolus; homologous to human ZC3HC1, a NuBaID
containing protein"
/codon_start=1
/product="Pml39p"
/protein_id="NP_013600.2"
/db_xref="GeneID:854864"
/db_xref="SGD:S000004575"
/translation="MEKDALEVRLKSIRHSLDKNTKLLPGKYRNTLGERLITKWRYKK
KSHNGSSMLPEKCKSHVQLYDDLVQESSKHFVGFRLHDLRALLKRICSIQNYTRHVLI
EWDVRWVNPLTLASKGWEPYQSASQSQVPFKCCCCHAIMTIPLLKNGDDVADYTMKLN
EKIWNSNIIGNHLQKCPWRENQVDLNKEYYLSSQNLIREIERIHTEIDRIVSGSNEFS
LKRNSSRIFHYLSEKEIQKLAFFFDCKDYSLVGLLLLGYTKFQKDDLVQCTACFHRAS
LKKLEYTEFNGHALWCRYYNKELLPTMLLELIGKEDKLITKLGVGERLNKLEAVLQTL
"
gene <56773..>57453
/gene="URA5"
/locus_tag="YML106W"
/gene_synonym="PYR5"
/db_xref="GeneID:854865"
mRNA <56773..>57453
/gene="URA5"
/locus_tag="YML106W"
/gene_synonym="PYR5"
/product="orotate phosphoribosyltransferase URA5"
/transcript_id="NM_001182468.1"
/db_xref="GeneID:854865"
CDS 56773..57453
/gene="URA5"
/locus_tag="YML106W"
/gene_synonym="PYR5"
/EC_number="2.4.2.10"
/experiment="EXISTENCE:direct assay:GO:0004588 orotate
phosphoribosyltransferase activity [PMID:9882434]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0046132 pyrimidine
ribonucleoside biosynthetic process [PMID:9882434]"
/experiment="EXISTENCE:mutant phenotype:GO:0004588 orotate
phosphoribosyltransferase activity [PMID:4550660]"
/experiment="EXISTENCE:mutant phenotype:GO:0006207 'de
novo' pyrimidine nucleobase biosynthetic process
[PMID:4550660]"
/experiment="EXISTENCE:mutant phenotype:GO:0046132
pyrimidine ribonucleoside biosynthetic process
[PMID:4550660]"
/note="Major orotate phosphoribosyltransferase (OPRTase)
isozyme; catalyzes the fifth enzymatic step in de novo
biosynthesis of pyrimidines, converting orotate into
orotidine-5'-phosphate; URA5 has a paralog, URA10, that
arose from the whole genome duplication"
/codon_start=1
/product="orotate phosphoribosyltransferase URA5"
/protein_id="NP_013601.1"
/db_xref="GeneID:854865"
/db_xref="SGD:S000004574"
/translation="MPIMLEDYQKNFLELAIECQALRFGSFKLKSGRESPYFFNLGLF
NTGKLLSNLATAYAIAIIQSDLKFDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQY
AFNRKEAKDHGEGGIIVGSALENKRILIIDDVMTAGTAINEAFEIISNAKGQVVGSII
ALDRQEVVSTDDKEGLSATQTVSKKYGIPVLSIVSLIHIITYLEGRITAEEKSKIEQY
LQTYGASA"
gene complement(<57866..>58687)
/gene="SEC65"
/locus_tag="YML105C"
/db_xref="GeneID:854866"
mRNA complement(<57866..>58687)
/gene="SEC65"
/locus_tag="YML105C"
/product="RNA-binding signal recognition particle subunit
SEC65"
/transcript_id="NM_001182467.1"
/db_xref="GeneID:854866"
CDS complement(57866..58687)
/gene="SEC65"
/locus_tag="YML105C"
/experiment="EXISTENCE:direct assay:GO:0005786 signal
recognition particle, endoplasmic reticulum targeting
[PMID:1313947|PMID:7925282]"
/experiment="EXISTENCE:direct assay:GO:0006614
SRP-dependent cotranslational protein targeting to
membrane [PMID:10921896]"
/experiment="EXISTENCE:direct assay:GO:0008312 7S RNA
binding [PMID:14681587]"
/experiment="EXISTENCE:mutant phenotype:GO:0005786 signal
recognition particle, endoplasmic reticulum targeting
[PMID:1313948]"
/experiment="EXISTENCE:mutant phenotype:GO:0006617
SRP-dependent cotranslational protein targeting to
membrane, signal sequence recognition [PMID:1313947]"
/note="Subunit of the signal recognition particle (SRP);
involved in protein targeting to the ER; interacts with
Srp54p; homolog of mammalian SRP19"
/codon_start=1
/product="RNA-binding signal recognition particle subunit
SEC65"
/protein_id="NP_013602.1"
/db_xref="GeneID:854866"
/db_xref="SGD:S000004573"
/translation="MPRLEEIDDFNDIDDLDMELAELDPSLRTPIAPKITPKVVRSQD
QENPAFLPGTNNNSNSNNNSSNEKEQLSFINPKTGKVERSEAISKKDLEEVKRFQVLY
PCYFDINRSHKEGRRVPKELAVENPLAKTMADAVRELGILCIFEGEKCHPQDFGNPGR
IRVLFKENGQLIGAATKFKGGKRQLMKAVGEYMKRHPTTIESLREIPYGPDFDNIEFK
KIPRVKGFKMNEIVPLHSPFLMGHPMTKSVYETPKITAAEKSFKPPKNKYKVVRR"
gene complement(<58939..>62322)
/gene="MDM1"
/locus_tag="YML104C"
/db_xref="GeneID:854867"
mRNA complement(<58939..>62322)
/gene="MDM1"
/locus_tag="YML104C"
/product="Mdm1p"
/transcript_id="NM_001182466.1"
/db_xref="GeneID:854867"
CDS complement(58939..62322)
/gene="MDM1"
/locus_tag="YML104C"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0032266
phosphatidylinositol-3-phosphate binding [PMID:11557775]"
/experiment="EXISTENCE:direct assay:GO:0071561
nucleus-vacuole junction [PMID:26283797]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0000001
mitochondrion inheritance [PMID:2202739|PMID:9245780]"
/experiment="EXISTENCE:mutant phenotype:GO:0034727
piecemeal microautophagy of the nucleus [PMID:33740659]"
/experiment="EXISTENCE:mutant phenotype:GO:1990854
vacuole-ER tethering [PMID:26283797]"
/note="PtdIns-3-P binding protein that tethers the ER to
vacuoles at NVJs; anchored in the ER membrane at
nucleus-vacuole junctions and binds phosphatidylinositol
3-phosphate (PtdIns-3-P) in the vacuolar membrane via its
Phox homology (PX) domain; expressed predominantly in late
G1 to early S phase of the cell cycle; mutation affects
nuclear and mitochondrial transmission to daughter buds;
similar to 4 human genes, one of which (SNX14) is
associated with neurological disease"
/codon_start=1
/product="Mdm1p"
/protein_id="NP_013603.1"
/db_xref="GeneID:854867"
/db_xref="SGD:S000004572"
/translation="MPKFPQFRLILVLFYLISMIQWSVITFSLGFFLNVCIFAYFVFF
KSLPDLPKPQPRFVDIVPESSNTVDVDKELKSVEGLIQDGNAQIGKELESIVNLIIKD
FVQPWFTKIDKNSDAEFLKVIKWRLLQTLLVVKDKLMKNDSASLIVLKLLPIFNKHFS
TFCDAREAVLSDLTLERHKSANIDLQIAVEFNKNYKIHKSLSLKPNALQKEIEKSIRK
TVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIFKFTDPDSWNLRIVSLSQNYF
EEKHKVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGKQFEHYLNQL
DSLLDLSDIKYVAYSLALKIYQLKENEHLTKENLKYKKRLLLSLNLIESKLSFPGSEI
DTASKKLAREANYPDLNMDNGIVLKEMASFLTSITLKDIVDDSEFLPFFESFLGSVPE
TQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGISTMQLQEISSKFFHNNNLQNMKL
LDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLDDRFLPLFKKTPSFL
KMLSTSHIISTDIYAHFLSRIGGVNNPEQNKIIKDNVKTDFMNPVRIFANPGITDALD
NIVNGSGSKPHKSRISSNPRYSQLFGSENDNIFKDKLFDDENDNTSEISVVEDQLDHP
RNMEKVSVSSGNSGLNPSQFYGSNNFRDNIASLTISIDQIEKELELLRHLILKADLTN
NQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSLFRKTKIYIRSYFSENSSNGL
KEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLKKNFRDLMRQLQDLFPSKVKM
SLKYHVTKTLLYEERKQKLEKYLRELLSISEICEDNIFRRFLTDPTPFKLNKEYMHDD
ILEEPLHEPIGSSNSTSNSSSVVDLQSSEDGGELNFYEDERHFFTDSGYPFYSQNKSF
VKQICDLFISLFALNKANAGWLRGRAIITVLQQLLGSTIEKYIKVSIQKLRSEDQVFE
AIVTFKNMLWGDNGLFERKRNETAEATRSEGERLRTEQLALTSLQRLFADTCGRVVGL
RDSHEAAGRVHAMLQNPYLNASLLLEALDAILLDIICND"
gene complement(<62582..>67549)
/gene="NUP188"
/locus_tag="YML103C"
/db_xref="GeneID:854868"
mRNA complement(<62582..>67549)
/gene="NUP188"
/locus_tag="YML103C"
/product="Nup188p"
/transcript_id="NM_001182465.1"
/db_xref="GeneID:854868"
CDS complement(62582..67549)
/gene="NUP188"
/locus_tag="YML103C"
/experiment="EXISTENCE:direct assay:GO:0005643 nuclear
pore [PMID:10684247]"
/experiment="EXISTENCE:direct assay:GO:0044611 nuclear
pore inner ring [PMID:18046406]"
/experiment="EXISTENCE:genetic interaction:GO:0006606
protein import into nucleus [PMID:16361228]"
/experiment="EXISTENCE:genetic interaction:GO:0006999
nuclear pore organization [PMID:8682855]"
/experiment="EXISTENCE:genetic interaction:GO:0017056
structural constituent of nuclear pore
[PMID:16361228|PMID:8682855]"
/experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear
pore organization [PMID:8682855]"
/experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA
export from nucleus in response to heat stress
[PMID:18258809]"
/note="Subunit of the inner ring of the nuclear pore
complex (NPC); contributes to NPC organization and
nucleocytoplasmic transport; homologous to human NUP188"
/codon_start=1
/product="Nup188p"
/protein_id="NP_013604.1"
/db_xref="GeneID:854868"
/db_xref="SGD:S000004571"
/translation="MATPSFGNSSPQLTFTHVANFMNDAAADVSAVDAKQLAQIRQFL
KANKTNLIESLNTIRQNVTSSGDHNKLRSTIANLLQINVDNDPFFAQSEDLSHAVEFF
MSERSSRLHIVYSLLVNPDIDLETYSFIDNDRFNVVGKLISIISSVIQNYDIITASSL
AHDYNNDQDMFTIVSLVQLKKFSDLKFILQILQILNLMILNTKVPVDIVNQWFLQYQN
QFVEFCRNINSTDKSIDTSSLQLYKFQNFQDLSYLSETLISRISSLFTITTILILGLN
TSIAQFDIQSPLYMDTETFDTVNSALENDVATNIVNEDPIFHPMIHYSWSFILYYRRA
LQSSESFDDSDITKFALFAESHDVLQKLNTLSEILSFDPVYTTVITVFLEFSLNFIPI
TASTSRVFAKIISKAPEQFIENFLTNDTFEKKLSIIKAKLPLLNESLIPLINLALIDT
EFANFELKDICSFAVTKSSLNDLDYDLIADTITNSSSSSDIIVPDLIELKSDLLVAPP
LENENSNCLLSIPKSTKGKILTIKQQQQQQQQQNGQQPPTTSNLIIFLYKFNGWSLVG
RILQNLLHSYMEKGTQLDDLQHELMISIIKLVTNVVDPKTSIEKSSEILSYLSNSLDT
SASTINGASIIQVIFEIFEISLQRKDYTSIVQCCEFMTMLTPNYLHLVSSYLNKSDLL
DKYGKTGLSNMILGSVELSTGDYTFTIQLLKLTKVFIRESLSLKNIHISKRSKIDIIN
KLILHAIHIFESYYNWKYNNFLQKFEIAFHLTLIFYDVLHDVFTINPHQKDQLIISSS
ANKLLQLFLTPMDSIDLAPNTLTNILISPLNTTTKILGDKILGNLYSKVMNNSFKLCT
LLIAIRGSNRDLKPSNLEKLLFINSSKLVDVYTLPSYVHFKVQIIELLSYLVEAPWND
DYPFLLSFLGEAKSMAFLKEVLSDLSSPVQDWNLLRSLYIFFTTLLESKQDGLSILFL
TGQFASNKKINDESSIDKKSSILTVLQKNSLLLDSTPEEVSCKLLETITYVLNTWTNS
KIFIKDPKFVNSLLAKLKDSKKLFQKKENLTRDETVSLIKKYKLISRIVEIFALCIYN
STDSNSEILNFLNQEDLFELVHHFFQIDGFNKTFHDELNLKFKEKWPSLELQSFQKIP
LSRINENENFGYDIPLLDIVLKADRSWNEPSKSQTNFKEEITDASLNLQYVNYEISTA
KAWGALITTFVKRSTVPLNDGFVDLVEHFLKLNIDFGSDKQMFTQIYLERIELSFYIL
YSFKLSGKLLKEEKIIELMNKIFTIFKSGEIDFIKNIGKSLKNNFYRPLLRSVLVLLE
LVSSGDRFIELISDQLLEFFELVFSKGVYLILSEILCQINKCSTRGLSTDHTTQIVNL
EDNTQDLLLLLSLFKKITNVNPSKNFNVILASSLNEVGTLKVILNLYSSAHLIRINDE
PILGQITLTFISELCSIEPIAAKLINSGLYSVLLESPLSVAIQQGDIKPEFSPRLHNI
WSNGLLSIVLLLLSQFGIKVLPETCLFVSYFGKQIKSTIYNWGDNKLAVSSSLIKETN
QLVLLQKMLNLLNYQELFIQPKNSDDQQEAVELVIGLDSEHDKKRLSAALSKFLTHPK
YLNSRIIPTTLEEQQQLEDESSRLEFVKGISRDIKALQDSLFKDV"
gene complement(67768..67938)
/gene="SNR85"
/locus_tag="YNCM0002C"
/db_xref="GeneID:9164957"
ncRNA complement(67768..67938)
/ncRNA_class="snoRNA"
/gene="SNR85"
/locus_tag="YNCM0002C"
/product="SNR85"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:15923376]"
/experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA
pseudouridylation guide activity [PMID:15923376]"
/experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA
pseudouridine synthesis [PMID:15923376]"
/experiment="EXISTENCE:physical interaction:GO:0031429 box
H/ACA snoRNP complex [PMID:15923376]"
/note="H/ACA box small nucleolar RNA (snoRNA); predicted
to guide pseudouridylation of small subunit (SSU) rRNA at
position U1181"
/transcript_id="NR_132234.1"
/db_xref="GeneID:9164957"
/db_xref="SGD:S000081376"
gene <68294..>69700
/gene="CAC2"
/locus_tag="YML102W"
/db_xref="GeneID:854869"
mRNA <68294..>69700
/gene="CAC2"
/locus_tag="YML102W"
/product="Cac2p"
/transcript_id="NM_001182464.1"
/db_xref="GeneID:854869"
CDS 68294..69700
/gene="CAC2"
/locus_tag="YML102W"
/experiment="EXISTENCE:direct assay:GO:0000775 chromosome,
centromeric region [PMID:11782447]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0006335 DNA
replication-dependent chromatin assembly [PMID:9030687]"
/experiment="EXISTENCE:direct assay:GO:0033186 CAF-1
complex [PMID:9030687]"
/experiment="EXISTENCE:direct assay:GO:0042393 histone
binding [PMID:16503640]"
/experiment="EXISTENCE:mutant phenotype:GO:0006335 DNA
replication-dependent chromatin assembly [PMID:9030687]"
/note="Subunit of chromatin assembly factor I (CAF-1),
with Rlf2p and Msi1p; chromatin assembly by CAF-1 is
important for multiple processes including silencing at
telomeres, mating type loci, and rDNA; maintenance of
kinetochore structure, deactivation of the DNA damage
checkpoint after DNA repair, chromatin dynamics during
transcription; and repression of divergent transcription;
relocalizes to the cytosol in response to hypoxia"
/codon_start=1
/product="Cac2p"
/protein_id="NP_013605.1"
/db_xref="GeneID:854869"
/db_xref="SGD:S000004570"
/translation="MEASHLQIYWHDSQPVYSLTFQKNSANDKLFTAGGDNKVRIWKL
NRDENGQNGGVRKIESLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWKQED
PNTQQESVVRPFGMDAETSEADENKEKWVVWKRLRGGSGATAAAEIYDLAWSPDNRNI
VVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGVIL
SSAGVVTGLKLRSKIAKAELPCPGDVLRTNYLFHNETLPSFFRRCSISPCGGLVVIPS
GVYKVAGDEVANCVYVYTRSGILNSAGGVKNRPAIRIPSLKKPALMAAFSPVFYETCQ
KSVLKLPYKLVFAIATTNEVLVYDTDVLEPLCVVGNIHYSPITDLAWSEDGSTLLISS
TDGFCSYVSIDTETQFGSRIEPPAMHAEPLDTDESAVAAKNQREAGGIVNMLPVKKIP
CNSSDSKKRRIHPTPVDL"
gene complement(<69735..>70088)
/gene="CUE4"
/locus_tag="YML101C"
/db_xref="GeneID:854871"
mRNA complement(<69735..>70088)
/gene="CUE4"
/locus_tag="YML101C"
/product="Cue4p"
/transcript_id="NM_001182462.1"
/db_xref="GeneID:854871"
CDS complement(69735..70088)
/gene="CUE4"
/locus_tag="YML101C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/note="hypothetical protein; has a CUE domain that binds
ubiquitin, which may facilitate intramolecular
monoubiquitination; CUE4 has a paralog, CUE1, that arose
from the whole genome duplication"
/codon_start=1
/product="Cue4p"
/protein_id="NP_013607.1"
/db_xref="GeneID:854871"
/db_xref="SGD:S000004568"
/translation="MDGSTIVFILTMVCLFVYTVKHRGAKQVPSRTVQDAKPAPSVAT
NDPSPEPVPSAPEERVARLNRHGSDRKRAVNSDMVEIVMTMAPHVPQEKVVQDLRNTG
SIEHTMENIFAGKLD"
gene <70138..>70311
/locus_tag="YML100W-A"
/db_xref="GeneID:1466496"
mRNA <70138..>70311
/locus_tag="YML100W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184612.1"
/db_xref="GeneID:1466496"
CDS 70138..70311
/locus_tag="YML100W-A"
/note="hypothetical protein; identified by gene-trapping,
microarray-based expression analysis, and genome-wide
homology searching"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878138.1"
/db_xref="GeneID:1466496"
/db_xref="SGD:S000028688"
/translation="MYKCVPSYYSKAGTIVVTYCEISALLVSLKNRVQGKRGETEGQI
EISRKAGHPAPAF"
gene <70624..>73920
/gene="TSL1"
/locus_tag="YML100W"
/db_xref="GeneID:854872"
mRNA <70624..>73920
/gene="TSL1"
/locus_tag="YML100W"
/product="trehalose 6-phosphate synthase/phosphatase
complex subunit"
/transcript_id="NM_001182460.1"
/db_xref="GeneID:854872"
CDS 70624..73920
/gene="TSL1"
/locus_tag="YML100W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0030234 enzyme
regulator activity [PMID:8404905]"
/experiment="EXISTENCE:genetic interaction:GO:0004805
trehalose-phosphatase activity [PMID:9837904]"
/experiment="EXISTENCE:mutant phenotype:GO:0003825
alpha,alpha-trehalose-phosphate synthase (UDP-forming)
activity [PMID:9837904]"
/experiment="EXISTENCE:mutant phenotype:GO:0004805
trehalose-phosphatase activity [PMID:9837904]"
/experiment="EXISTENCE:mutant phenotype:GO:0005992
trehalose biosynthetic process [PMID:9837904]"
/experiment="EXISTENCE:physical interaction:GO:0005946
alpha,alpha-trehalose-phosphate synthase complex
(UDP-forming) [PMID:9837904]"
/note="Large subunit of trehalose 6-phosphate
synthase/phosphatase complex; Tps1p-Tps2p complex converts
uridine-5'-diphosphoglucose and glucose 6-phosphate to
trehalose; contributes to survival to acute lethal heat
stress; mutant has aneuploidy tolerance; protein abundance
increases in response to DNA replication stress; TSL1 has
a paralog, TPS3, that arose from the whole genome
duplication"
/codon_start=1
/product="trehalose 6-phosphate synthase/phosphatase
complex subunit"
/protein_id="NP_013608.1"
/db_xref="GeneID:854872"
/db_xref="SGD:S000004566"
/translation="MALIVASLFLPYQPQFELDTSLPENSQVDSSLVNIQAMANDQQQ
QRALSNNISQESLVAPAPEQGVPPAISRSATRSPSAFNRASSTTNTATLDDLVSSDIF
MENLTANATTSHTPTSKTMLKPRKNGSVERFFSPSSNIPTDRIASPIQHEHDSGSRIA
SPIQQQQQDPTTNLLKNVNKSLLVHSLLNNTSQTSLEGPNNHIVTPKSRAGNRPTSAA
TSLVNRTKQGSASSGSSGSSAPPSIKRITPHLTASAAKQRPLLAKQPSNLKYSELADI
SSSETSSQHNESDPDDLTTAPDEEYVSDLEMDDAKQDYKVPKFGGYSNKSKLKKYALL
RSSQELFSRLPWSIVPSIKGNGAMKNAINTAVLENIIPHRHVKWVGTVGIPTDEIPEN
ILANISDSLKDKYDSYPVLTDDDTFKAAYKNYCKQILWPTLHYQIPDNPNSKAFEDHS
WKFYRNLNQRFADAIVKIYKKGDTIWIHDYHLMLVPQMVRDVLPFAKIGFTLHVSFPS
SEVFRCLAQREKILEGLTGADFVGFQTREYARHFLQTSNRLLMADVVHDEELKYNGRV
VSVRFTPVGIDAFDLQSQLKDGSVMQWRQLIRERWQGKKLIVCRDQFDRIRGIHKKLL
AYEKFLVENPEYVEKSTLIQICIGSSKDVELERQIMIVVDRINSLSTNISISQPVVFL
HQDLDFSQYLALSSEADLFVVSSLREGMNLTCHEFIVCSEDKNAPLLLSEFTGSASLL
NDGAIIINPWDTKNFSQAILKGLEMPFDKRRPQWKKLMKDIINNDSTNWIKTSLQDIH
ISWQFNQEGSKIFKLNTKTLMEDYQSSKKRMFVFNIAEPPSSRMISILNDMTSKGNIV
YIMNSFPKPILENLYSRVQNIGLIAENGAYVSLNGVWYNIVDQVDWRNDVAKILEDKV
ERLPGSYYKINESMIKFHTENAEDQDRVASVIGDAITHINTVFDHRGIHAYVYKNVVS
VQQVGLSLSAAQFLFRFYNSASDPLDTSSGQITNIQTPSQQNPSDQEQQPPASPTVSM
NHIDFACVSGSSSPVLEPLFKLVNDEASEGQVKAGHAIVYGDATSTYAKEHVNGLNEL
FTIISRIIED"
gene complement(<74398..>77040)
/gene="ARG81"
/locus_tag="YML099C"
/gene_synonym="ARGR2"
/db_xref="GeneID:854874"
mRNA complement(<74398..>77040)
/gene="ARG81"
/locus_tag="YML099C"
/gene_synonym="ARGR2"
/product="Arg81p"
/transcript_id="NM_001182459.1"
/db_xref="GeneID:854874"
CDS complement(74398..77040)
/gene="ARG81"
/locus_tag="YML099C"
/gene_synonym="ARGR2"
/experiment="EXISTENCE:direct assay:GO:0003712
transcription coregulator activity [PMID:10688655]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:3311884]"
/experiment="EXISTENCE:mutant phenotype:GO:0000821
regulation of arginine metabolic process [PMID:10688655]"
/note="Zinc finger transcription factor involved in
arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster
domain type; involved in the regulation of
arginine-responsive genes; acts with Arg80p and Arg82p"
/codon_start=1
/product="Arg81p"
/protein_id="NP_013610.1"
/db_xref="GeneID:854874"
/db_xref="SGD:S000004565"
/translation="MGISSKNGPKKMGRAKTFTGCWTCRGRKVKCDLRHPHCQRCEKS
NLPCGGYDIKLRWSKPMQFDPYGVPIPQNSPATTTNLSGSVDEPQYQRRNIDFVRYDE
EYVYHEDMDDELTMLHTPPIEKISDNKTWIIKKFGVFKGTDKIDKQYAPRKKRNRKRV
AKSLESSASISLSSLPSSSTISFPIRHIEDKLRNKGHVKTGILSANDGVPPTPNLLDY
DWNNLNITGYEWISSELRDDALLSAVTLQGHHLGHTQPQEISLEENSNVVSGEEHVNA
KEHGCAFEADNQGSSTLPNKAASANDKLYQQNLKLLFQKNSSNSEEPDPQALIDDVFV
NIEPRSLPASDLNKITLAPPNEESRMPKSMLELTSYSSDLPPELVDIIPKTDLTVHGL
ARFLLNHYFNNVADKMTVVVLEKNPWKTLYFPRALMALGDLAGLGQSSNSRNALLNAL
LAVSCFHLQSKYPRNYKLQKYFLGLGIELRNQASNFLRLCLNTKSSIPEKYKDVLTAI
LSMNSIDVVWGTMADCQDHLALCEDFVESRMKLRPNISEKTKTLHRIFSFLKLIQDST
ALDKVRAKEIVILPSEEDDNYKPLDTSNATTSSSEPRVDVVQEGLFREALNENDGKIH
IEFVKEPITNVSADSTPSSTTPPIFTNIATESYYNKSDISKLVSKTDENIIGTDSLYG
LPNSLILLFSDCVRIVRHNEYYNLTYLPVPRKFNELSLNFEKRLLKWKSEWNFHQENS
EGKSFINSTAEALYHHTMSFYFSLIIYYFTMARSLNCQFLQNYVAKVLDHLNAMEELV
DQKKVKIVPLIWQGFMAGCACTDENRQQEFRRWAAKLAESGVGSYWGARQVMLEVWRR
RKEDEPGDNWYSVYKDWEMNLMLS"
gene <77267..>77770
/gene="TAF13"
/locus_tag="YML098W"
/gene_synonym="FUN81; TAF19"
/db_xref="GeneID:854875"
mRNA <77267..>77770
/gene="TAF13"
/locus_tag="YML098W"
/gene_synonym="FUN81; TAF19"
/product="Taf13p"
/transcript_id="NM_001182458.1"
/db_xref="GeneID:854875"
CDS 77267..77770
/gene="TAF13"
/locus_tag="YML098W"
/gene_synonym="FUN81; TAF19"
/experiment="EXISTENCE:curator inference:GO:0016251 RNA
polymerase II general transcription initiation factor
activity []"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005669
transcription factor TFIID complex
[PMID:10788514|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0006366
transcription by RNA polymerase II
[PMID:12138208|PMID:15448131]"
/experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
polymerase II preinitiation complex assembly
[PMID:12840001]"
/note="TFIID subunit (19 kDa); involved in RNA polymerase
II transcription initiation, similar to histone H4 with
atypical histone fold motif of Spt3-like transcription
factors"
/codon_start=1
/product="Taf13p"
/protein_id="NP_013611.1"
/db_xref="GeneID:854875"
/db_xref="SGD:S000004564"
/translation="MSRKLKKTNLFNKDVSSLLYAYGDVPQPLQATVQCLDELVSGYL
VDVCTNAFHTAQNSQRNKLRLEDFKFALRKDPIKLGRAEELIATNKLITEAKKQFNET
DNQNSLKRYREEDEEGDEMEEDEDEQQVTDDDEEAAGRNSAKQSTDSKATKIRKQGPK
NLKKTKK"
gene complement(<78335..>79690)
/gene="VPS9"
/locus_tag="YML097C"
/gene_synonym="VPL31; VPT9"
/db_xref="GeneID:854876"
mRNA complement(<78335..>79690)
/gene="VPS9"
/locus_tag="YML097C"
/gene_synonym="VPL31; VPT9"
/product="guanine nucleotide exchange factor VPS9"
/transcript_id="NM_001182457.1"
/db_xref="GeneID:854876"
CDS complement(78335..79690)
/gene="VPS9"
/locus_tag="YML097C"
/gene_synonym="VPL31; VPT9"
/experiment="EXISTENCE:direct assay:GO:0005085
guanyl-nucleotide exchange factor activity
[PMID:10329739|PMID:23612966]"
/experiment="EXISTENCE:direct assay:GO:0005769 early
endosome [PMID:31754649]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:23612966|PMID:26928762|PMID:8628304]"
/experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin
binding [PMID:12628920]"
/experiment="EXISTENCE:genetic interaction:GO:0006895
Golgi to endosome transport [PMID:23612966]"
/experiment="EXISTENCE:genetic interaction:GO:0032511 late
endosome to vacuole transport via multivesicular body
sorting pathway [PMID:23612966]"
/experiment="EXISTENCE:genetic interaction:GO:0036010
protein localization to endosome [PMID:23264632]"
/experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole
inheritance [PMID:1493335]"
/experiment="EXISTENCE:mutant phenotype:GO:0006623 protein
targeting to vacuole [PMID:8628304]"
/experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi
to endosome transport [PMID:22748138|PMID:23612966]"
/experiment="EXISTENCE:mutant phenotype:GO:0032511 late
endosome to vacuole transport via multivesicular body
sorting pathway [PMID:23612966]"
/note="Guanine nucleotide exchange factor (GEF) and
ubiquitin receptor; involved in vesicle-mediated vacuolar
transport, including Golgi-endosome trafficking and
sorting through the multivesicular body (MVB); stimulates
the intrinsic guanine nucleotide exchange activity of Rab
family members (Vps21p/Ypt52p/Ypt53p); partially redundant
with GEF MUK1; required for localization of the CORVET
complex to endosomes; similar to mammalian ras inhibitors;
contains a Ub-interacting CUE domain"
/codon_start=1
/product="guanine nucleotide exchange factor VPS9"
/protein_id="NP_013612.1"
/db_xref="GeneID:854876"
/db_xref="SGD:S000004563"
/translation="MTDDEKREILKEFDPFSQLEQANGNPDKDVKFKKDDPNRAAAEE
TNRDISAQDKGDEEPFYDFQIFIKQLQTPGADPLVKYTKSFLRNFLAQRLLWTVSEEI
KLISDFKTFIYDKFTLYEPFRSLDNSKMRNAKEGMEKLIMGKLYSRCFSPSLYEILQK
PLDDEHMKDLTNDDTLLEKIRHYRFISPIMLDIPDTMPNARLNKFVHLASKELGKINR
FKSPRDKMVCVLNASKVIFGLLKHTKLEQNGADSFIPVLIYCILKGQVRYLVSNVNYI
ERFRSPDFIRGEEEYYLSSLQAALNFIMNLTERSLTIEDHEDFEEAYQRNFKQLAEEK
EEEEKKKQLEIPDELQPNGTLLKPLDEVTNIVISKFNELFSPIGEPTQEEALKSEQSN
KEEDVSSLIKKIEENERKDTLNTLQNMFPDMDPSLIEDVCIAKKSRIGPCVDALLSLS
E"
gene <79909..>81486
/locus_tag="YML096W"
/db_xref="GeneID:854877"
mRNA <79909..>81486
/locus_tag="YML096W"
/product="putative asparagine synthase"
/transcript_id="NM_001182456.1"
/db_xref="GeneID:854877"
CDS 79909..81486
/locus_tag="YML096W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="Putative protein with similarity to asparagine
synthetases; green fluorescent protein (GFP)-fusion
protein localizes to the cytoplasm; YML096W is not an
essential gene and partially overlaps the verified gene
RAD10"
/codon_start=1
/product="putative asparagine synthase"
/protein_id="NP_013613.1"
/db_xref="GeneID:854877"
/db_xref="SGD:S000004562"
/translation="MCGILLHYCPNNNYLNDELIEFPEGTEFGDTTCTNESSIFNKII
PYIAARGPNYSSLRAVKAYRISWFSSVLSLRQPFTKQSINVDDRYFLQFNGELYNKEI
SQGDNDSLYIASMLQNLKEGMGVIDVIKSLEGEYAYTIYDVNSSKLYFGRDPIGRRSL
SYSVTPDNELYVASVTGSAGSFQDCIGGVIYEYDTRTKLLNSNQRSHLPYEVTSEIDL
NFTSLSEVSKNLYAVLRDSVKKRVESIHPRHIENSPIAVLFSGGIDCSVIVALICEVL
QENDYKCGKPVIELLNVSFENPRTGLFPSDTPDRKLSINSAKTLQNLYPNVDIKLVEV
DVPYDEYLKWKPFVINLMYPKQTEMDLSIAIAFFFASRGRGFLTSLNGERTPYQRHGI
VLFSGLGADELYGGYHKFANKPPHELVEELTRQINNIYDRNLNRDDKVIAHNGVEVRY
PFLDEYVIKLSTAEIPINFKVNKLILRKVASQYLKLDGISSEPKRAIQFGAKSAKMTK
DGNKHGTDLLKENRNCS"
gene complement(<81481..>82113)
/gene="RAD10"
/locus_tag="YML095C"
/db_xref="GeneID:854878"
mRNA complement(<81481..>82113)
/gene="RAD10"
/locus_tag="YML095C"
/product="DNA repair protein RAD10"
/transcript_id="NM_001182454.1"
/db_xref="GeneID:854878"
CDS complement(81481..82113)
/gene="RAD10"
/locus_tag="YML095C"
/experiment="EXISTENCE:direct assay:GO:0000014
single-stranded DNA endodeoxyribonuclease activity
[PMID:8253764]"
/experiment="EXISTENCE:direct assay:GO:0003697
single-stranded DNA binding [PMID:1741062]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9852079]"
/experiment="EXISTENCE:direct assay:GO:0006289
nucleotide-excision repair [PMID:7559571]"
/experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic
mismatch repair [PMID:11514439]"
/experiment="EXISTENCE:mutant phenotype:GO:0000735 removal
of nonhomologous ends [PMID:7891718]"
/experiment="EXISTENCE:mutant phenotype:GO:0000736
double-strand break repair via single-strand annealing,
removal of nonhomologous ends [PMID:7891718]"
/experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA
amplification [PMID:23271978]"
/experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic
recombination [PMID:2188090]"
/experiment="EXISTENCE:physical interaction:GO:0000110
nucleotide-excision repair factor 1 complex
[PMID:8621533]"
/note="Single-stranded DNA endonuclease (with Rad1p);
cleaves single-stranded DNA during nucleotide excision
repair and double-strand break repair; subunit of
Nucleotide Excision Repair Factor 1 (NEF1); homolog of
human ERCC1 protein"
/codon_start=1
/product="DNA repair protein RAD10"
/protein_id="NP_013614.1"
/db_xref="GeneID:854878"
/db_xref="SGD:S000004560"
/translation="MNNTDPTSFESILAGVAKLRKEKSGADTTGSQSLEIDASKLQQQ
EPQTSRRINSNQVINAFNQQKPEEWTDSKATDDYNRKRPFRSTRPGKTVLVNTTQKEN
PLLNHLKSTNWRYVSSTGINMIYYDYLVRGRSVLFLTLTYHKLYVDYISRRMQPLSRN
ENNILIFIVDDNNSEDTLNDITKLCMFNGFTLLLAFNFEQAAKYIEYLNL"
gene <82275..>82849
/gene="GIM5"
/locus_tag="YML094W"
/gene_synonym="PFD5"
/db_xref="GeneID:854879"
mRNA join(<82275..82290,82374..>82849)
/gene="GIM5"
/locus_tag="YML094W"
/gene_synonym="PFD5"
/product="Gim5p"
/transcript_id="NM_001182453.1"
/db_xref="GeneID:854879"
CDS join(82275..82290,82374..82849)
/gene="GIM5"
/locus_tag="YML094W"
/gene_synonym="PFD5"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:9463374]"
/experiment="EXISTENCE:direct assay:GO:0015631 tubulin
binding [PMID:9463374]"
/experiment="EXISTENCE:genetic interaction:GO:0032968
positive regulation of transcription elongation by RNA
polymerase II [PMID:24068951]"
/experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin
complex assembly [PMID:9463374]"
/experiment="EXISTENCE:mutant phenotype:GO:0032968
positive regulation of transcription elongation by RNA
polymerase II [PMID:24068951]"
/experiment="EXISTENCE:physical interaction:GO:0016272
prefoldin complex [PMID:9463374]"
/note="Subunit of the heterohexameric cochaperone
prefoldin complex; prefoldin binds specifically to
cytosolic chaperonin and transfers target proteins to it;
prefoldin complex also localizes to chromatin of actively
transcribed genes in the nucleus and facilitates
transcriptional elongation"
/codon_start=1
/product="Gim5p"
/protein_id="NP_013616.1"
/db_xref="GeneID:854879"
/db_xref="SGD:S000004559"
/translation="MSSQKIDLTKLNPEQLNAVKQQFDQELQHFTQSLQALTMAKGKF
TECIDDIKTVSQAGNEGQKLLVPASASLYIPGKIVDNKKFMVDIGTGYYVEKSAEAAI
AFYQKKVDKLNKESVQIQDIIKEKTQYSLSIEAQIRQAAIRQHEAMSKQQQQQQKKES
STA"
gene <83090..>85789
/gene="UTP14"
/locus_tag="YML093W"
/db_xref="GeneID:854881"
mRNA <83090..>85789
/gene="UTP14"
/locus_tag="YML093W"
/product="Utp14p"
/transcript_id="NM_001182452.1"
/db_xref="GeneID:854881"
CDS 83090..85789
/gene="UTP14"
/locus_tag="YML093W"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:12068309]"
/experiment="EXISTENCE:direct assay:GO:0032040
small-subunit processome [PMID:12068309]"
/experiment="EXISTENCE:mutant phenotype:GO:0000447
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from
5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]"
/experiment="EXISTENCE:mutant phenotype:GO:0000472
endonucleolytic cleavage to generate mature 5'-end of
SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
[PMID:15489292]"
/experiment="EXISTENCE:mutant phenotype:GO:0000480
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA
transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
[PMID:15489292]"
/note="Subunit of U3-containing Small Subunit (SSU)
processome complex; involved in production of 18S rRNA and
assembly of small ribosomal subunit"
/codon_start=1
/product="Utp14p"
/protein_id="NP_013617.1"
/db_xref="GeneID:854881"
/db_xref="SGD:S000004558"
/translation="MAKKKSKSRSKSSRRVLDALQLAEREINGEFDNSSDNDKRHDAR
RNGTVVNLLKRSKGDTNSDEDDIDSESFEDEELNSDEALGSDDDYDILNSKFSQTIRD
KKENANYQEEEDEGGYTSIDEEDLMPLSQVWDMDEKTAQSNGNDDEDASPQLKLQDTD
ISSESSSSEESESESEDDEEEEDPFDEISEDEEDIELNTITSKLIDETKSKAPKRLDT
YGSGEANEYVLPSANAASGASGKLSLTDMMNVIDDRQVIENANLLKGKSSTYEVPLPQ
RIQQRHDRKAAYEISRQEVSKWNDIVQQNRRADHLIFPLNKPTEHNHASAFTRTQDVP
QTELQEKVDQVLQESNLANPEKDSKFEELSTAKMTPEEMRKRTTEMRLMRELMFREER
KARRLKKIKSKTYRKIKKKELMKNRELAAVSSDEDNEDHDIARAKERMTLKHKTNSKW
AKDMIKHGMTNDAETREEMEEMLRQGERLKAKMLDRNSDDEEDGRVQTLSDVENEEKE
NIDSEALKSKLGKTGVMNMAFMKNGEAREREANKETLRQLRAVENGDDIKLFESDEEE
TNGENIQINKGRRIYTPGSLESNKDMNELNDHTRKENKVDESRSLENRLRAKNSGQSK
NARTNAEGAIIVEEESDGEPLQDGQNNQQDEEAKDVNPWLANESDEEHTVKKQSSKVN
VIDKDSSKNVKAMNKMEKAELKQKKKKKGKSNDDEDLLLTADDSTRLKIVDPYGGSDD
EQGDNVFMFKQQDVIAEAFAGDDVVAEFQEEKKRVIDDEDDKEVDTTLPGWGEWAGAG
SKPKNKKRKFIKKVKGVVNKDKRRDKNLQNVIINEKVNKKNLKYQSSAVPFPFENREQ
YERSLRMPIGQEWTSRASHQELIKPRIMTKPGQVIDPLKAPFK"
gene complement(<85987..>86739)
/gene="PRE8"
/locus_tag="YML092C"
/db_xref="GeneID:854882"
mRNA complement(<85987..>86739)
/gene="PRE8"
/locus_tag="YML092C"
/product="proteasome core particle subunit alpha 2"
/transcript_id="NM_001182451.1"
/db_xref="GeneID:854882"
CDS complement(85987..86739)
/gene="PRE8"
/locus_tag="YML092C"
/experiment="EXISTENCE:direct assay:GO:0010499 proteasomal
ubiquitin-independent protein catabolic process
[PMID:19162040]"
/experiment="EXISTENCE:direct assay:GO:0019773 proteasome
core complex, alpha-subunit complex [PMID:9087403]"
/experiment="EXISTENCE:direct assay:GO:0034515 proteasome
storage granule [PMID:18504300]"
/experiment="EXISTENCE:direct assay:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:11545745|PMID:19029916]"
/note="Alpha 2 subunit of the 20S proteasome"
/codon_start=1
/product="proteasome core particle subunit alpha 2"
/protein_id="NP_013618.1"
/db_xref="GeneID:854882"
/db_xref="SGD:S000004557"
/translation="MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVV
IATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYG
EYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWK
ATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDEN
PDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL"
gene complement(<87123..>90731)
/gene="RPM2"
/locus_tag="YML091C"
/db_xref="GeneID:854883"
mRNA complement(<87123..>90731)
/gene="RPM2"
/locus_tag="YML091C"
/product="ribonuclease P"
/transcript_id="NM_001182450.1"
/db_xref="GeneID:854883"
CDS complement(87123..90731)
/gene="RPM2"
/locus_tag="YML091C"
/EC_number="3.1.26.5"
/experiment="EXISTENCE:direct assay:GO:0001682 tRNA
5'-leader removal [PMID:8366116]"
/experiment="EXISTENCE:direct assay:GO:0004526
ribonuclease P activity [PMID:8366116]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:16024791]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:7544434]"
/experiment="EXISTENCE:direct assay:GO:0030677
ribonuclease P complex [PMID:8366116]"
/experiment="EXISTENCE:direct assay:GO:0030678
mitochondrial ribonuclease P complex [PMID:3537697]"
/experiment="EXISTENCE:direct assay:GO:0045944 positive
regulation of transcription by RNA polymerase II
[PMID:16024791]"
/experiment="EXISTENCE:genetic interaction:GO:0006397 mRNA
processing [PMID:17267405]"
/experiment="EXISTENCE:mutant phenotype:GO:0002181
cytoplasmic translation [PMID:11404323]"
/experiment="EXISTENCE:mutant phenotype:GO:0006396 RNA
processing [PMID:11522833]"
/experiment="EXISTENCE:mutant phenotype:GO:0007005
mitochondrion organization [PMID:11404323]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:16024791]"
/experiment="EXISTENCE:mutant phenotype:GO:0097745
mitochondrial tRNA 5'-end processing [PMID:30759361]"
/experiment="EXISTENCE:physical interaction:GO:0006397
mRNA processing [PMID:17267405]"
/note="Protein subunit of mitochondrial RNase P; has roles
in nuclear transcription, cytoplasmic and mitochondrial
RNA processing, and mitochondrial translation; distributed
to mitochondria, cytoplasmic processing bodies, and the
nucleus"
/codon_start=1
/product="ribonuclease P"
/protein_id="NP_013619.1"
/db_xref="GeneID:854883"
/db_xref="SGD:S000004556"
/translation="MAFKSFIYSKGYHRSAAQKKTATSFFDSSYQYLRQNQGLVNSDP
VLHASHLHPHPVVVANVNYNNVDDILHPHDLDSSINNTNNPLTHEELLYNQNVSLRSL
KQQQSTNYVNNNNNNQHRYYSTGPTLPTNQYDPLNFSNRNFQDLSLKTSQPSVQQPQN
EYSLLKDENAPVWKEDTEPCLNKSTYLQTHIDEINRCYEQKNYNKINSLYQSLKRNDI
VPPLEIFTKVLDSLCKRPLDNNDLDNKMYELLTCYQDMINNRLKPPDEIYNIVLLSLF
KGSILAYQFENPNGSDFYKIAIELFNTTTNDPKQKSVVKFRNFSKDVLDYNLLAMNIY
PGHITLSKAQQVIKSSPAFIKDSFYFIACFSYAKLTNDKFAIKELYEDFRLSLSSGSP
DQGLFDDQFEIYSVILSSFIETGEVELATNLLDDLVSKIQSSNGLASNISLLLSSFLI
SMSKVDPSKAYEIWFKFHNLNWIPEFSYEFYLVFMANSFQDWNLTKKIYDYIFPMERN
LSPLKKQKLSDYLLHPIGVDSITTSLLDYSLQLKDNEVIMKILEESIVKNFSFDIGIY
PFVFNYLREIQCGEDYLMRFIESHAEFIKKSNSINKFQFLNMIVDNFQSQSLLNKISH
AKFFKNFVEDFNLENCELVSYNGLISCINNFIKIPKTIKDFPYILEIHAILVTKLFDF
DTYPILQNGNNEVLLKFRDQIEHQFKMLAQNFCRLNLDPNLLAGVVSQAMKMVNLDDT
ANGQDLLNFFNHPGDWDKSYPLSLGSFIRNSPRGGIREFTKLSKEGYCFDYDTYKELI
IKRAINKQIIDKCLEVCPDSIELKNIVNLMISKIPGRNLTQLIINNPKFSKVFVPNLR
NDSMLKLIENCESLSNFIRICDFPEKFKSIAIQAENKNAIELIYERLFDGGKYADILR
YNNIVPVLNLELLLKSCIRSGEFKKYESLSKKFNDKISESSKIDIQLEYLINKNDLKG
AFTLFEKTPRELRTPHKTMDLYTFALFLDSFNRNITYYESPENTLQFANILSSQTSFI
NLLSTYNLIAHSDHLMNFNVGGMAAKVKKEILNQMLNNLYDSIRLLSPSIENDKSMKE
KLREKVKNYCRFKAYLKSPELDMDELKTLVSVESFLNPFTPSMLFNNLIETIYINEHA
SSLVLQNGLIYSLQQKGLNKILSYLEESFITSGNDANIEKVREFRSLLRKSKPLQA"
gene 91970..92027
/gene="ZOD1"
/locus_tag="YNCM0003W"
/db_xref="GeneID:23547382"
ncRNA 91970..92027
/ncRNA_class="other"
/gene="ZOD1"
/locus_tag="YNCM0003W"
/product="ZOD1"
/note="tDNA relic, ancient tDNA for tRNA-Ile; weakly
transcribed by RNA polymerase III; located upstream of
UFO1; associated with components of the Pol III machinery:
Tfc4p, Brf1p, Bdp1, and Rpc34p"
/transcript_id="NR_132235.1"
/db_xref="GeneID:23547382"
/db_xref="SGD:S000077071"
gene <92235..>94241
/gene="UFO1"
/locus_tag="YML088W"
/db_xref="GeneID:854886"
mRNA <92235..>94241
/gene="UFO1"
/locus_tag="YML088W"
/product="SCF ubiquitin ligase complex subunit UFO1"
/transcript_id="NM_001182447.1"
/db_xref="GeneID:854886"
CDS 92235..94241
/gene="UFO1"
/locus_tag="YML088W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14506225]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14506225|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0019005 SCF
ubiquitin ligase complex [PMID:11283612|PMID:14747994]"
/experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA
damage response [PMID:10963670]"
/experiment="EXISTENCE:mutant phenotype:GO:0031146
SCF-dependent proteasomal ubiquitin-dependent protein
catabolic process [PMID:10963670]"
/experiment="EXISTENCE:mutant phenotype:GO:0071406
cellular response to methylmercury [PMID:17141224]"
/experiment="EXISTENCE:physical interaction:GO:0019005 SCF
ubiquitin ligase complex [PMID:14506225|PMID:14747994]"
/experiment="EXISTENCE:physical interaction:GO:0031146
SCF-dependent proteasomal ubiquitin-dependent protein
catabolic process [PMID:14506225]"
/note="F-box receptor protein; subunit of the
Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase
complex; binds to phosphorylated Ho endonuclease, allowing
its ubiquitination by SCF and subsequent degradation"
/codon_start=1
/product="SCF ubiquitin ligase complex subunit UFO1"
/protein_id="NP_013622.1"
/db_xref="GeneID:854886"
/db_xref="SGD:S000004553"
/translation="MERPGLVLQDLPPEILINIFSHLDEKDLFTLQELSTHFRNLIHD
EELWKNLFKSRVHTTHFPTFSQSSKFSVEYIERTRGLHHWQHNKAIRTKYTIIPTRNW
DQPSIERIVFDYPRVAAYNDGTITILQLQNHKRQKKFKKLIYIPCTTPQGCSTMDFNI
NAAVFGRFDGRVFGKLLSNKSYLTPVMEFTGRHSAGVTAICNSESWDTSREDWSVSGS
ENGEIIWWCENKLVKMWKVSNRVIWKLAFFKDWTLIMDDEKLYIIHQMQELHSIDIPK
DLDEQPMRVRFFKMDFGSMTLVLADLNNVYTISVNPNGNFGNLRKLEMPEQICAVEID
EKTSQREQNWQFAGDDGCYISLLTTQNTLYIINIRDLSSSGLKVQCKISFDEQVYVSQ
VTNLIVVVALPNVLQILNAMTGELIKTVLKTEKFPEFLKVSQDKIIMGSGNVLNYLKF
VSSDSKKHHHSTKGKNTVSNKWNETLNTELQYYDEDEDLRRKRQSEISRLIDAYGGDL
ELSGDTDEENDIQLRIALLESQEAQARNQAEAGEPVGDDEDEQLRRALEESQLIYETQ
TNSSANHGNNTNDEIDEDDEEFLRAIRQSRVEDERRRHLRNHTTGRRNGPLSDDNFAT
YGAAESSERTSTENTIGSSVGVDASNNVDEDLQLAIALSLSEIN"
rep_origin 94217..94463
/note="ARS1305; Autonomously Replicating Sequence"
/db_xref="SGD:S000118366"
gene complement(<94431..>95369)
/gene="AIM33"
/locus_tag="YML087C"
/db_xref="GeneID:854887"
mRNA complement(<94431..>95369)
/gene="AIM33"
/locus_tag="YML087C"
/product="cytochrome-b5 reductase"
/transcript_id="NM_001182446.1"
/db_xref="GeneID:854887"
CDS complement(94431..95369)
/gene="AIM33"
/locus_tag="YML087C"
/note="hypothetical protein, highly conserved across
species; homolog of human CYB5R4; null mutant displays
reduced frequency of mitochondrial genome loss; AIM33 has
a paralog, PGA3, that arose from the whole genome
duplication"
/codon_start=1
/product="cytochrome-b5 reductase"
/protein_id="NP_013623.1"
/db_xref="GeneID:854887"
/db_xref="SGD:S000004552"
/translation="MSIVETCISFVSTNPFYPFCTGLLLNCVVTPLYFWKTQNGRIVV
VSLLQFVVLYATAFISIGTDKSLYRNKWVALPLSKKTRISRNTSLYCFKLKYPFERLH
IPMGYHLAVRVTINGERLVRYYTPVNVPNTEGHLELVVKTYKHGVVSKYFDKLKIRQY
VEFKGPLGELEYDQDTATELGIIAGGSGITPVLQVLQEIIPSPEDLTHISLIYANETE
DDILMKSQLDHMAKEYPHFKVHYVIHKPNGKWNGDVGYVTLEEMKRYLPKQAEDHRLL
ICGPPKMNEMVLNYAKELGWSNGFHKGNGTDKVFVF"
gene complement(<95791..>97371)
/gene="ALO1"
/locus_tag="YML086C"
/db_xref="GeneID:854888"
mRNA complement(<95791..>97371)
/gene="ALO1"
/locus_tag="YML086C"
/product="D-arabinono-1,4-lactone oxidase"
/transcript_id="NM_001182445.1"
/db_xref="GeneID:854888"
CDS complement(95791..97371)
/gene="ALO1"
/locus_tag="YML086C"
/EC_number="1.1.3.37"
/experiment="EXISTENCE:direct assay:GO:0003885
D-arabinono-1,4-lactone oxidase activity [PMID:10094636]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:10094636|PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane
[PMID:16407407|PMID:16689936]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress [PMID:10094636]"
/experiment="EXISTENCE:mutant phenotype:GO:0070485
dehydro-D-arabinono-1,4-lactone biosynthetic process
[PMID:10094636]"
/note="D-Arabinono-1,4-lactone oxidase; catalyzes the
final step in biosynthesis of
dehydro-D-arabinono-1,4-lactone, which is protective
against oxidative stress; null mutant shows improved
incorporation efficiency of noncanonical amino acids in
place of amber stop codon"
/codon_start=1
/product="D-arabinono-1,4-lactone oxidase"
/protein_id="NP_013624.1"
/db_xref="GeneID:854888"
/db_xref="SGD:S000004551"
/translation="MSTIPFRKNYVFKNWAGIYSAKPERYFQPSSIDEVVELVKSARL
AEKSLVTVGSGHSPSNMCVTDEWLVNLDRLDKVQKFVEYPELHYADVTVDAGMRLYQL
NEFLGAKGYSIQNLGSISEQSVAGIISTGSHGSSPYHGLISSQYVNLTIVNGKGELKF
LDAENDPEVFKAALLSVGKIGIIVSATIRVVPGFNIKSTQEVITFENLLKQWDTLWTS
SEFIRVWWYPYTRKCVLWRGNKTTDAQNGPAKSWWGTKLGRFFYETLLWISTKIYAPL
TPFVEKFVFNRQYGKLEKSSTGDVNVTDSISGFNMDCLFSQFVDEWGCPMDNGLEVLR
SLDHSIAQAAINKEFYVHVPMEVRCSNTTLPSEPLDTSKRTNTSPGPVYGNVCRPFLD
NTPSHCRFAPLENVTNSQLTLYINATIYRPFGCNTPIHKWFTLFENTMMVAGGKPHWA
KNFLGSTTLAAGPVKKDTDYDDFEMRGMALKVEEWYGEDLKKFRKIRKEQDPDNVFLA
NKQWAIINGIIDPSELSD"
gene complement(<97941..>99400)
/gene="TUB1"
/locus_tag="YML085C"
/db_xref="GeneID:854889"
mRNA complement(join(<97941..99259,99376..>99400))
/gene="TUB1"
/locus_tag="YML085C"
/product="alpha-tubulin TUB1"
/transcript_id="NM_001182444.1"
/db_xref="GeneID:854889"
CDS complement(join(97941..99259,99376..99400))
/gene="TUB1"
/locus_tag="YML085C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:25817432]"
/experiment="EXISTENCE:direct assay:GO:0045298 tubulin
complex [PMID:9488492]"
/experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic
sister chromatid segregation [PMID:16582437]"
/experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear
migration along microtubule [PMID:16582437]"
/experiment="EXISTENCE:mutant phenotype:GO:0045143
homologous chromosome segregation [PMID:16582437]"
/experiment="EXISTENCE:physical interaction:GO:0045298
tubulin complex [PMID:9488492]"
/note="Alpha-tubulin; associates with beta-tubulin (Tub2p)
to form tubulin dimer, which polymerizes to form
microtubules; relative distribution to nuclear foci
increases upon DNA replication stress; TUB1 has a paralog,
TUB3, that arose from the whole genome duplication"
/codon_start=1
/product="alpha-tubulin TUB1"
/protein_id="NP_013625.1"
/db_xref="GeneID:854889"
/db_xref="SGD:S000004550"
/translation="MREVISINVGQAGCQIGNACWELYSLEHGIKPDGHLEDGLSKPK
GGEEGFSTFFHETGYGKFVPRAIYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDAAN
NYARGHYTVGREILGDVLDRIRKLADQCDGLQGFLFTHSLGGGTGSGLGSLLLEELSA
EYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAIYDMCKRNL
DIPRPSFANLNNLIAQVVSSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYSPV
LSKSKAFHESNSVSEITNACFEPGNQMVKCDPRDGKYMATCLLYRGDVVTRDVQRAVE
QVKNKKTVQLVDWCPTGFKIGICYEPPTATPNSQLATVDRAVCMLSNTTSIAEAWKRI
DRKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGADSYAEEEEF"
gene complement(<99794..>101050)
/locus_tag="YML083C"
/db_xref="GeneID:854891"
mRNA complement(<99794..>101050)
/locus_tag="YML083C"
/product="uncharacterized protein"
/transcript_id="NM_001182442.1"
/db_xref="GeneID:854891"
CDS complement(99794..101050)
/locus_tag="YML083C"
/note="hypothetical protein; transcriptionally regulated
by Upc2p via an upstream sterol response element; strong
increase in transcript abundance during anaerobic growth
compared to aerobic growth; cells deleted for YML083C do
not exhibit growth defects in anerobic or anaerobic
conditions"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013627.1"
/db_xref="GeneID:854891"
/db_xref="SGD:S000004548"
/translation="MDYLHVYNNNQAHVPRTPPGRQCLSPVLPPIILALDQQHSLTFG
YSSPRCLPTPILPSMSTNTPVHWSQQVVTIPVAVRNHAAMMPIITPMTSPRPQFEATA
PSPPLAPVAIKLPDLKLPPSPVPSTVEDRVSHPILPKIVIGNGGGRDVERDSTEELIR
KIPNYIGCAKTKAQLSKVRSGKQLIACAQEYHHPVNKDEIENINNILNFRDFIFKHPK
SSFEFLCTLSFEQFVRVYSFISFIYRTKKINKNKYELVCEMNVHEQLSNKRIQRTRTP
EKYKIHLICESKLILTFNHCTKTVKFESINGGHCHPISANHIIKPSLFLTHCINKCYQ
TVSDPTDLKLALRDALEALDHERIGLSFLKRRHFKCSHQASSLSNASATLKKQEDHDT
FGVHTGIIHTANFFMFNASSDIFQRN"
gene <101862..>103811
/locus_tag="YML082W"
/db_xref="GeneID:854892"
mRNA <101862..>103811
/locus_tag="YML082W"
/product="putative cystathionine gamma-synthase"
/transcript_id="NM_001182441.1"
/db_xref="GeneID:854892"
CDS 101862..103811
/locus_tag="YML082W"
/EC_number="2.5.1.48"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="Putative protein predicted to have carbon-sulfur
lyase activity; transcriptionally regulated by Upc2p via
an upstream sterol response element; green fluorescent
protein (GFP)-fusion protein localizes to the nucleus and
the cytoplasm; not an essential gene; YML082W has a
paralog, STR2, that arose from the whole genome
duplication"
/codon_start=1
/product="putative cystathionine gamma-synthase"
/protein_id="NP_013628.1"
/db_xref="GeneID:854892"
/db_xref="SGD:S000004547"
/translation="MVSAQVATELGQPIPLDTQHAVSVCFPTWKSVISYVEKDPKVLG
CLKSGYPRFWIHPSIQKLRDILIEKYAKENETCFCFPSYRVAKRCREYVRRKCAHRNG
KVRILQLATAKPINEEQKTWKRECKIAVVFVDGAYENILKQYWQYTGEIISSRLAEYV
LHELFMVEKKSSPAEEKEYIEMRYGRNLNFAFADRAKELIKKRIATKVIDKDEHDEEE
NYHFLAGNQDEQDFQDTFLDSSLNEANHGEDHDGGISGEVDSQEEPHNGLVSTIPPEP
IEMSTIEEEQSVEEDAGRCALRVCPERDVFLFPSGMASIFTAHRLLLQWDSLRLNRSR
NGSDVTSSPPNKKTVIFGFPYADTLHVLQEFNETYFLGEGDESSMKELTKILHSGEQI
LAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPFADIVCSSLT
KTFSGDSNVIGGSMVLNPQSRVYEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIAR
TIRINYSTEYLLDKILKPHVGENKLFKKIYYPNLTSKETLTNYDMVRCKKEGGYGGLF
SLTFHDEDHAAAFYDNLKLNKGPSLGTNFTLAFPYTLMTYYHELDMAEKFGVERNLLR
ISVGLESQSILGKIFQEAIDKTVEI"
gene complement(<103983..>104162)
/gene="ATP18"
/locus_tag="YML081C-A"
/db_xref="GeneID:854893"
mRNA complement(<103983..>104162)
/gene="ATP18"
/locus_tag="YML081C-A"
/product="F1F0 ATP synthase subunit i"
/transcript_id="NM_001184340.1"
/db_xref="GeneID:854893"
CDS complement(103983..104162)
/gene="ATP18"
/locus_tag="YML081C-A"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005753
mitochondrial proton-transporting ATP synthase complex
[PMID:20219971]"
/experiment="EXISTENCE:direct assay:GO:0015986 proton
motive force-driven ATP synthesis [PMID:20691145]"
/experiment="EXISTENCE:direct assay:GO:0046933
proton-transporting ATP synthase activity, rotational
mechanism [PMID:20691145]"
/experiment="EXISTENCE:mutant phenotype:GO:0000276
mitochondrial proton-transporting ATP synthase complex,
coupling factor F(o) [PMID:9867807]"
/experiment="EXISTENCE:mutant phenotype:GO:0015986 proton
motive force-driven ATP synthesis
[PMID:9867807|PMID:9867878]"
/experiment="EXISTENCE:mutant phenotype:GO:0033615
mitochondrial proton-transporting ATP synthase complex
assembly [PMID:20219971]"
/experiment="EXISTENCE:mutant phenotype:GO:0046933
proton-transporting ATP synthase activity, rotational
mechanism [PMID:9867807]"
/experiment="EXISTENCE:mutant phenotype:GO:0065003
protein-containing complex assembly [PMID:20219971]"
/note="Subunit of the mitochondrial F1F0 ATP synthase;
F1F0 ATP synthase is a large, evolutionarily conserved
enzyme complex required for ATP synthesis; termed subunit
I or subunit j; does not correspond to known ATP synthase
subunits in other organisms"
/codon_start=1
/product="F1F0 ATP synthase subunit i"
/protein_id="NP_013629.1"
/db_xref="GeneID:854893"
/db_xref="SGD:S000007247"
/translation="MLKRFPTPILKVYWPFFVAGAAVYYGMSKAADLSSNTKEFINDP
RNPRFAKGGKFVEVD"
gene <104777..>108532
/gene="TDA9"
/locus_tag="YML081W"
/gene_synonym="AAF1"
/db_xref="GeneID:854894"
mRNA <104777..>108532
/gene="TDA9"
/locus_tag="YML081W"
/gene_synonym="AAF1"
/product="Tda9p"
/transcript_id="NM_001182440.1"
/db_xref="GeneID:854894"
CDS 104777..108532
/gene="TDA9"
/locus_tag="YML081W"
/gene_synonym="AAF1"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding
[PMID:16785442|PMID:19111667|PMID:19158363]"
/experiment="EXISTENCE:mutant phenotype:GO:0019413 acetate
biosynthetic process [PMID:23240040]"
/note="Transcription factor that regulates acetate
production; green fluorescent protein (GFP)-fusion protein
localizes to the nucleus; null mutant is sensitive to
expression of the top1-T722A allele; not an essential
gene; TDA9 has a paralog, RSF2, that arose from the whole
genome duplication"
/codon_start=1
/product="Tda9p"
/protein_id="NP_013630.1"
/db_xref="GeneID:854894"
/db_xref="SGD:S000004546"
/translation="MSSEEFKGLPIKRDISSTIYADRPPALSAPPCVGATGNDKIQVL
PIPKKSRTIKTDKPRPFLCHICTRGFVRQEHLKRHQRAHTNEKPFLCVFCGRCFARRD
LVLRHQHKLHSALVSKESINSKDKTEIDAINDKNIIQIQGNKQTILPTPSNPLAKTAV
QLKKAAKEKKNGKQGKLDLSPSYGANNHSTDVSPSVGNSSTPAVIEETDSSSHFPLPD
TNIPTKSKRHASFSASSAFTYSSDNFQKLHQQAKSDFDELQESIPHQVGFSTPQLTAQ
QLIENAIESGVVDLETLDLPPFLSLDGLPPASSSAAVAASEQIDICPSSATDTISGAN
STPNQAATAPPFQLPIARESSSLFLANTPYLSDFLTMGSSYGGSGGFAKSITADPSLD
YFNYKNHSHPDSRHNNSSSGINYSNNKNNNESIEKSQNNSNVINETIDHTDIHAHHAD
AHDDSFIESEEWLSKFIMDSQIDNDLKLNINHFNDIGFNNLHPQNPTTHSEPRNMHNE
NRDMHRSASKFQSVSENISPREQMSLFKTKQNKAISKFLSDEKIPSTASPSSSASPVQ
FDKKNVDINEFLLDESVSNLFTTRQIDLFKKNVNLYSPLFQNQKDAVSSTSLTPSLTT
QTATTQSGPGWTDSSQKLTFFTEQLRNLIIKENNLKSNLFPTVDELNHYVDLYQVEFH
KYFPFIHLYSIIPSSENYPLVISISMIGALYGFHSTHALLLSKIARTRVRMFLENTRS
NHDKTPIWLMQSLVLLTFTSIFSNDMNAFRTVNTQIMILVQLIKISKLNYPLENFIKP
PIESDHVLEYQDNPAVLNQFKAQYNTREQINRNFKYFILAQSRIRICHIVLLISNLFK
SLVDFDCCFHSIDLKCGVPCYNEVLFFCENSRTWNENLTRFNIVLDSKFSLIEVSNGE
SNYEKCLMYLSNGNPYLYKNAKISFKTLLSLLISIHEKINIERDALKDSYESDFHAKN
VQWRMHSRPLVATMLKHWELLYIKNGGILALSDENLPIINTNPSFRLIIPLYFFAKLR
KCLDIAPTLRCIWNQDWNSMNSSLEKVCYERESLREATEYAVSVITFWIDTVSVMKGK
STQTPIFTITCIFVSILVIAGYMRRLEDFAQNKNSDCMIGSLKSTDRILWLKAFKTLK
RIESHLSEREYKLQTFAEFLRVPDNGSLDIESLDSSLIENTLNSHDVTNQALDIITRT
RLSSRTLYCGARILGDTPVWPVSLLFAHALQSRAIYNINHRKSVNSV"
gene <108806..>110077
/gene="DUS1"
/locus_tag="YML080W"
/db_xref="GeneID:854895"
mRNA <108806..>110077
/gene="DUS1"
/locus_tag="YML080W"
/product="tRNA dihydrouridine synthase"
/transcript_id="NM_001182439.1"
/db_xref="GeneID:854895"
CDS 108806..110077
/gene="DUS1"
/locus_tag="YML080W"
/EC_number="1.3.1.88"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006400 tRNA
modification [PMID:12003496]"
/experiment="EXISTENCE:direct assay:GO:0017150 tRNA
dihydrouridine synthase activity [PMID:12003496]"
/experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA
modification [PMID:14970222]"
/experiment="EXISTENCE:mutant phenotype:GO:0017150 tRNA
dihydrouridine synthase activity [PMID:14970222]"
/note="Dihydrouridine synthase; member of a widespread
family of conserved proteins including Smm1p, Dus3p, and
Dus4p; modifies pre-tRNA(Phe) at U17"
/codon_start=1
/product="tRNA dihydrouridine synthase"
/protein_id="NP_013631.1"
/db_xref="GeneID:854895"
/db_xref="SGD:S000004545"
/translation="MTEPALSSANNALMQKLTGRQLFDKIGRPTRIVAPMVDQSELAW
RILSRRYGATLAYTPMLHAKLFATSKKYREDNWSSLDGSSVDRPLVVQFCANDPEYLL
AAAKLVEDKCDAVDLNLGCPQGIAKKGHYGSFLMEEWDLIHNLINTLHKNLKVPVTAK
IRIFDDCEKSLNYAKMVLDAGAQFLTVHGRVREQKGQKTGLANWETIKYLRDNLPKET
VFFANGNILYPEDISRCMEHIGADAVMSAEGNLYNPGVFNVGQTKNKEKIFPRVDKII
REYFQIVKECQESKASKTAMKSHFFKILRPFLPHHTDIRSTLATMNAKATWEEWEEQV
VKPVEKVVQEIFEQPDIAIKDEITIGEKQSWGGSYRTVPYWRCQPYFRPVNGITGDKR
VMQGLIDESVNKKRKADVPLESADKKKDVKA"
gene <110247..>110852
/gene="CFF1"
/locus_tag="YML079W"
/db_xref="GeneID:854896"
mRNA <110247..>110852
/gene="CFF1"
/locus_tag="YML079W"
/product="Cff1p"
/transcript_id="NM_001182438.1"
/db_xref="GeneID:854896"
CDS 110247..110852
/gene="CFF1"
/locus_tag="YML079W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0072527
pyrimidine-containing compound metabolic process
[PMID:36598488]"
/note="Protein required for production of
4-hydroxy-5-methylfuran-3(2H)-one (MHF); cupin superfamily
protein; has structural resemblance to plant storage and
ligand binding proteins (canavalin, glycinin, auxin
binding protein) and to some enzymes (epimerase, germin);
localizes to nucleus and cytoplasm"
/codon_start=1
/product="Cff1p"
/protein_id="NP_013632.1"
/db_xref="GeneID:854896"
/db_xref="SGD:S000004544"
/translation="MSANVQEAANAAIEPASFVKVPMPEPPSSLQQLINDWQLIKHRE
GGYFKETDRSPYTMEVEKPVNGGSGNTEMVTRNQSTLIYYLLTPDSPIGKFHKNINRI
IHILQRGKGQYVLVYPDGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFDNG
FLISEVVVPGFDFEDHTFLKGEDELKHLVGPEKAAELAFLA"
gene <111002..>111550
/gene="CPR3"
/locus_tag="YML078W"
/gene_synonym="CYP3"
/db_xref="GeneID:854897"
mRNA <111002..>111550
/gene="CPR3"
/locus_tag="YML078W"
/gene_synonym="CYP3"
/product="peptidylprolyl isomerase CPR3"
/transcript_id="NM_001182437.1"
/db_xref="GeneID:854897"
CDS 111002..111550
/gene="CPR3"
/locus_tag="YML078W"
/gene_synonym="CYP3"
/EC_number="5.2.1.8"
/experiment="EXISTENCE:direct assay:GO:0003755
peptidyl-prolyl cis-trans isomerase activity
[PMID:7603990]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14576278|PMID:16823961|PMID:24769239|PMID:7603990]"
/experiment="EXISTENCE:direct assay:GO:0006457 protein
folding [PMID:7603990]"
/experiment="EXISTENCE:mutant phenotype:GO:0006915
apoptotic process [PMID:17881727]"
/note="Mitochondrial peptidyl-prolyl cis-trans isomerase
(cyclophilin); catalyzes the cis-trans isomerization of
peptide bonds N-terminal to proline residues; involved in
protein refolding after import into mitochondria"
/codon_start=1
/product="peptidylprolyl isomerase CPR3"
/protein_id="NP_013633.1"
/db_xref="GeneID:854897"
/db_xref="SGD:S000004543"
/translation="MFKRSIIQQSRLFSNSASRLGKKVFFDPAVNGTKIGRIEFELYD
NVVPKTAENFRALCTGEKGWGYKGVPFHRIIPDFMIQGGDTDLTNGFGGKSIYGSKFA
DENFVKKHDKAGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVTKGMDIVKAI
ESYGTASGKPRAEIVIEEAGEL"
gene <111865..>112344
/gene="BET5"
/locus_tag="YML077W"
/db_xref="GeneID:854898"
mRNA <111865..>112344
/gene="BET5"
/locus_tag="YML077W"
/product="TRAPP subunit BET5"
/transcript_id="NM_001182436.1"
/db_xref="GeneID:854898"
CDS 111865..112344
/gene="BET5"
/locus_tag="YML077W"
/experiment="EXISTENCE:direct assay:GO:0005085
guanyl-nucleotide exchange factor activity
[PMID:17110339]"
/experiment="EXISTENCE:direct assay:GO:1990070 TRAPPI
protein complex [PMID:11239471]"
/experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII
protein complex [PMID:11239471]"
/experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII
protein complex [PMID:20375281]"
/experiment="EXISTENCE:genetic interaction:GO:0005085
guanyl-nucleotide exchange factor activity [PMID:9611195]"
/experiment="EXISTENCE:genetic interaction:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:9611195]"
/experiment="EXISTENCE:mutant phenotype:GO:0005085
guanyl-nucleotide exchange factor activity
[PMID:17287728]"
/experiment="EXISTENCE:mutant phenotype:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:11239471|PMID:9611195]"
/note="Core component of transport protein particle
(TRAPP) complexes I-III; TRAPP complexes are related
multimeric guanine nucleotide-exchange factors for the
GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI),
intra-Golgi traffic (TRAPPII), endosome-Golgi traffic
(TRAPPII and III) and autophagy (TRAPPIII); human homology
TRAPPC1 complements yeast null mutant"
/codon_start=1
/product="TRAPP subunit BET5"
/protein_id="NP_013634.1"
/db_xref="GeneID:854898"
/db_xref="SGD:S000004542"
/translation="MGIYSFWIFDRHCNCIFDREWTLASNSASGTINSKQNEEDAKLL
YGMIFSLRSITQKLSKGSVKNDIRSISTGKYRVHTYCTASGLWFVLLSDFKQQSYTQV
LQYIYSHIYVKYVSNNLLSPYDFAENENEMRGQGTRKITNRNFISVLESFLAPMVNQ"
gene complement(<112513..>115347)
/gene="WAR1"
/locus_tag="YML076C"
/db_xref="GeneID:854899"
mRNA complement(<112513..>115347)
/gene="WAR1"
/locus_tag="YML076C"
/product="War1p"
/transcript_id="NM_001182435.1"
/db_xref="GeneID:854899"
CDS complement(112513..115347)
/gene="WAR1"
/locus_tag="YML076C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:12588995]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding [PMID:12588995]"
/experiment="EXISTENCE:direct assay:GO:0045944 positive
regulation of transcription by RNA polymerase II
[PMID:12588995]"
/experiment="EXISTENCE:mutant phenotype:GO:0003700
DNA-binding transcription factor activity [PMID:12588995]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:12588995]"
/note="Homodimeric Zn2Cys6 zinc finger transcription
factor; binds to a weak acid response element to induce
transcription of PDR12 and FUN34, encoding an acid
transporter and a putative ammonia transporter,
respectively"
/codon_start=1
/product="War1p"
/protein_id="NP_013635.1"
/db_xref="GeneID:854899"
/db_xref="SGD:S000004541"
/translation="MDTQIAITGVAVGKEINNDNSKTDQKVSLPKADVPCIDKATQTI
IEGCSKDDPRLSYPTKLETTEKGKTKRNSFACVCCHSLKQKCEPSDVNDIYRKPCRRC
LKHKKLCKFDLSKRTRKRKPRSRSPTPFESPMVNVSTKSKGPTDSEESSLKDGTSYLA
SFPSDPNAKQFPNSRTVLPGLQQSLSDLWSTLSQPPSYGAREAETTSTGEITTNNHTK
SNGSVPTNPAVLASNDEHTNISDAPVIYSTYNSPVPISSAPTSINSEALFKHRPKIVG
DEETQNVKVKRQKKSYSRHMTRSFRKQLQSLIISQKGKIRDISMKLDTWSKQWNDLVE
KSMFLPTIADPVSVGIISHEEATLRLHLYKTEISYLSKLPFIKVEENVSVDELRKKKP
ILFSVIMSCVSIVLTPKQTTRGTIMKLDSFVLNLITNQIFKANNKSIEIIESLSTLCL
WYNFFEWSSKTRYHIFNYICCCLTRDLGPTYVNRSFGMFSDEDPKRFKSPLELYSNGA
SLTLLVYISALNISIFLRQSIQARWSHVTEKACEDLVKETKKSRHYDNDKLLLDSADD
PILVQFAKMNHVLENIHTHLHERDLNDDEFDDPIFTKKYLNKLMEKYHKQLQEIFTKL
DRNRPRVIAFYYSVEAYLYQYKLAVFIGEMSHTINEKVELPREIMDDFVKCYHCCKSA
LEEFSKLEPILITSLPLFHTSRIIYTVGMLLLKLRYSVVAIPSFHDLMPLTDDAIALV
IGVNNLLEKTSELYPFNNSLYKFRYVIALFCQTYANKVIDVADRYNAEREKLKEKQVI
DEVSNGHDGTKPINAYVTESQKMPTEEDPIIDNNTNQNITAVPDEMLPVYSRVRDDTA
AMNLNINSTSYMNESPHEHRESMTGTTLLPPPFISNDVTNSADSTNIKPSPSSSVDNL
NDYLTDINSLAWGVNSLNDEFWTDLFMNDI"
gene complement(<115734..>118898)
/gene="HMG1"
/locus_tag="YML075C"
/db_xref="GeneID:854900"
mRNA complement(<115734..>118898)
/gene="HMG1"
/locus_tag="YML075C"
/product="hydroxymethylglutaryl-CoA reductase (NADPH)
HMG1"
/transcript_id="NM_001182434.1"
/db_xref="GeneID:854900"
CDS complement(115734..118898)
/gene="HMG1"
/locus_tag="YML075C"
/EC_number="1.1.1.34"
/experiment="EXISTENCE:direct assay:GO:0004420
hydroxymethylglutaryl-CoA reductase (NADPH) activity
[PMID:3526336]"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:8744950]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:8744950]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:8744950]"
/experiment="EXISTENCE:direct assay:GO:0006696 ergosterol
biosynthetic process [PMID:3526336]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:22842922|PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0004420
hydroxymethylglutaryl-CoA reductase (NADPH) activity
[PMID:2828155]"
/experiment="EXISTENCE:mutant phenotype:GO:0004420
hydroxymethylglutaryl-CoA reductase (NADPH) activity
[PMID:2828155]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process [PMID:9292983]"
/note="HMG-CoA reductase; catalyzes conversion of HMG-CoA
to mevalonate, which is a rate-limiting step in sterol
biosynthesis; one of two isozymes; localizes to nuclear
envelope; overproduction induces formation of karmellae;
forms foci at nuclear periphery upon DNA replication
stress; expressed almost exclusively on the peri-nuclear
side of the ER; human homolog HMGCR can complement yeast
hmg1 mutant"
/codon_start=1
/product="hydroxymethylglutaryl-CoA reductase (NADPH)
HMG1"
/protein_id="NP_013636.1"
/db_xref="GeneID:854900"
/db_xref="SGD:S000004540"
/translation="MPPLFKGLKQMAKPIAYVSRFSAKRPIHIILFSLIISAFAYLSV
IQYYFNGWQLDSNSVFETAPNKDSNTLFQECSHYYRDSSLDGWVSITAHEASELPAPH
HYYLLNLNFNSPNETDSIPELANTVFEKDNTKYILQEDLSVSKEISSTDGTKWRLRSD
RKSLFDVKTLAYSLYDVFSENVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNF
WLSASTVVNSASSLFLALYVTQCILGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYAL
EKFERVGLSKRITTDEIVFESVSEEGGRLIQDHLLCIFAFIGCSMYAHQLKTLTNFCI
LSAFILIFELILTPTFYSAILALRLEMNVIHRSTIIKQTLEEDGVVPSTARIISKAEK
KSVSSFLNLSVVVIIMKLSVILLFVFINFYNFGANWVNDAFNSLYFDKERVSLPDFIT
SNASENFKEQAIVSVTPLLYYKPIKSYQRIEDMVLLLLRNVSVAIRDRFVSKLVLSAL
VCSAVINVYLLNAARIHTSYTADQLVKTEVTKKSFTAPVQKASTPVLTNKTVISGSKV
KSLSSAQSSSSGPSSSSEEDDSRDIESLDKKIRPLEELEALLSSGNTKQLKNKEVAAL
VIHGKLPLYALEKKLGDTTRAVAVRRKALSILAEAPVLASDRLPYKNYDYDRVFGACC
ENVIGYMPLPVGVIGPLVIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTK
DGMTRGPVVRFPTLKRSGACKIWLDSEEGQNAIKKAFNSTSRFARLQHIQTCLAGDLL
FMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWI
EGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLVGSAMAGSVGGFNAHAANLV
TAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAML
DLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGHLVQSHMTHNRKPAEP
TKPNNLDATDINRLKDGSVTCIKS"
gene complement(<120089..>121324)
/gene="FPR3"
/locus_tag="YML074C"
/gene_synonym="NPI46"
/db_xref="GeneID:854901"
mRNA complement(<120089..>121324)
/gene="FPR3"
/locus_tag="YML074C"
/gene_synonym="NPI46"
/product="peptidylprolyl isomerase FPR3"
/transcript_id="NM_001182433.1"
/db_xref="GeneID:854901"
CDS complement(120089..121324)
/gene="FPR3"
/locus_tag="YML074C"
/gene_synonym="NPI46"
/EC_number="5.2.1.8"
/experiment="EXISTENCE:direct assay:GO:0003755
peptidyl-prolyl cis-trans isomerase activity
[PMID:7525596|PMID:7925954|PMID:8051210]"
/experiment="EXISTENCE:direct assay:GO:0005527 macrolide
binding [PMID:7925954]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26359986]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:7525596|PMID:8051210]"
/experiment="EXISTENCE:direct assay:GO:0006334 nucleosome
assembly [PMID:24297734]"
/experiment="EXISTENCE:direct assay:GO:0051598 meiotic
recombination checkpoint signaling [PMID:16179256]"
/experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic
recombination checkpoint signaling [PMID:16179256]"
/note="Nucleolar peptidyl-prolyl cis-trans isomerase
(PPIase); FK506 binding protein; affects expression of
multiple genes via its role in nucleosome assembly;
phosphorylated by casein kinase II
(Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p;
PPIase domain acts as a transcriptional repressor when
tethered to DNA by lexA, and repressor activity is
dependent on PPIase activity; FPR3 has a paralog, FPR4,
that arose from the whole genome duplication"
/codon_start=1
/product="peptidylprolyl isomerase FPR3"
/protein_id="NP_013637.1"
/db_xref="GeneID:854901"
/db_xref="SGD:S000004539"
/translation="MSDLLPLATYSLNVEPYTPVPAIDVTMPITVRITMAALNPEAID
EENKPSTLRIIKRNPDFEDDDFLGGDFDEDEIDEESSEEEEEEKTQKKKKSKGKKAES
ESEDDEEDDDEDDEFQESVLLTLSPEAQYQQSLDLTITPEEEVQFIVTGSYAISLSGN
YVKHPFDTPMGVEGEDEDEDADIYDSEDYDLTPDEDEIIGDDMDDLDDEEEEEVRIEE
VQEEDEEDNDGEEEQEEEEEEEQKEEVKPEPKKSKKEKKRKHEEKEEEKKAKKVKKVE
FKKDLEEGPTKPKSKKEQDKHKPKSKVLEGGIVIEDRTIGDGPQAKRGARVGMRYIGK
LKNGKVFDKNTSGKPFAFKLGRGEVIKGWDIGVAGMSVGGERRIIIPAPYAYGKQALP
GIPANSELTFDVKLVSMKN"
gene complement(<123227..>124172)
/gene="RPL6A"
/locus_tag="YML073C"
/gene_synonym="YL16A"
/db_xref="GeneID:854902"
mRNA complement(join(<123227..123742,124158..>124172))
/gene="RPL6A"
/locus_tag="YML073C"
/gene_synonym="YL16A"
/product="ribosomal 60S subunit protein L6A"
/transcript_id="NM_001182432.1"
/db_xref="GeneID:854902"
CDS complement(join(123227..123742,124158..124172))
/gene="RPL6A"
/locus_tag="YML073C"
/gene_synonym="YL16A"
/experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic
translation [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
[PMID:6337137]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:18782943]"
/experiment="EXISTENCE:mutant phenotype:GO:0000027
ribosomal large subunit assembly [PMID:3282992]"
/note="Ribosomal 60S subunit protein L6A; N-terminally
acetylated; binds 5.8S rRNA; homologous to mammalian
ribosomal protein L6, no bacterial homolog; RPL6A has a
paralog, RPL6B, that arose from the whole genome
duplication"
/codon_start=1
/product="ribosomal 60S subunit protein L6A"
/protein_id="NP_013638.1"
/db_xref="GeneID:854902"
/db_xref="SGD:S000004538"
/translation="MSAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLA
GRFRGKRVVYLKHLEDNTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFN
VEYFAKEKLTKKEKKEANLFPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLS
ASFSLKNGDKPHMLKF"
gene complement(<124730..>129367)
/gene="TCB3"
/locus_tag="YML072C"
/db_xref="GeneID:854903"
mRNA complement(<124730..>129367)
/gene="TCB3"
/locus_tag="YML072C"
/product="Tcb3p"
/transcript_id="NM_001182431.1"
/db_xref="GeneID:854903"
CDS complement(124730..129367)
/gene="TCB3"
/locus_tag="YML072C"
/experiment="EXISTENCE:direct assay:GO:0005543
phospholipid binding [PMID:33933446]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005933 cellular
bud [PMID:13679573]"
/experiment="EXISTENCE:direct assay:GO:0008289 lipid
binding [PMID:15049706]"
/experiment="EXISTENCE:direct assay:GO:0032541 cortical
endoplasmic reticulum [PMID:22250200|PMID:23237950]"
/experiment="EXISTENCE:direct assay:GO:0120010
intermembrane phospholipid transfer [PMID:33933446]"
/experiment="EXISTENCE:genetic interaction:GO:0055091
phospholipid homeostasis [PMID:35440494]"
/experiment="EXISTENCE:genetic interaction:GO:0060304
regulation of phosphatidylinositol dephosphorylation
[PMID:23237950]"
/experiment="EXISTENCE:genetic interaction:GO:0090158
endoplasmic reticulum membrane organization
[PMID:23237950]"
/experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to
Golgi ceramide transport [PMID:33205016]"
/experiment="EXISTENCE:mutant phenotype:GO:0120010
intermembrane phospholipid transfer [PMID:33933446]"
/note="Lipid-binding ER tricalbin involved in ER-plasma
membrane tethering; one of at least 7 proteins (Ice2p,
Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering
and contact with the plasma membrane; regulates PI4P
levels by controlling access of Sac1p to its substrate
PI4P in the PM; regulates PM phospholipid homeostasis;
involved in intermembrane phospholipid transfer; also
localizes to the mitochondria in a phosphorylated state
and is enriched in bud membranes; mRNA is targeted to the
bud tip"
/codon_start=1
/product="Tcb3p"
/protein_id="NP_013639.1"
/db_xref="GeneID:854903"
/db_xref="SGD:S000004537"
/translation="MTGIKAQVHPPPDSTLFHEEEKKKVGGNLPQKVINQQERGSDHA
PSGHHQYHQLINHDANDTKTSNSVSDVSKGQKTADSNPEGKKQSSKDIFVASSAQKTN
QLPGPNPQGSIGAVPLEGLRPKEFRSAPSRKPNKFDTSITKPGVLDDLGKLDEKDIKE
KFHLDSDDKLFPWQNVGEFHASGKGSPNTKMSRVIKAYILENFYNDWYCNIATVLGTC
FFSWLFAYIGFSWWSMIFIFLGTATVYNAEYTRFNRNIRDDLKRVTVEETLSDRVEST
TWLNSFLSKFWVIYMPVLSQQVKDNVNPQLAGVAPGYGIDALAIDEFTLGSKAPTIKG
IKSYTKTGKNTVEMDWSFAFTPSDVSDMTATEAREKINPKISLGVTLGKSFVSKTMPI
LVEDINVAGKMRIKVEFGKAFPNIKIVSLQLLEPPLIDFALKPIGGDTLGLDVMSFLP
GLKSFVKNIINSNIGPMLFPPNHLDINVEDIMAAQSKEAIGVLAVTIASADSLKGSDF
ITNTVDPYIVMTTEDAVPGTDEEVRTSIKSNVKNPRWNETKYLLLNTLEQKLNLKCFD
FNDVRKDTVIGDLQLDLADLLQNPVLDNQTAELRSGTKSKGILHYSLHWFPVKEDKSE
EKAVERAEAKAKGKKEDENEDTTEKEEDENEESSQTDVGIAKITLQKVKYLDTTSSMT
GSLSPCAELFIDGQKVKSYRTLRRINEPSWNETIEVLVPSKSNSKFVLKIFDDRMNGK
ALICEYSSSLDDIMTTLDTAQEFVKGSPQGDIYLDVSWKSIEMTGAFAAANSVSEPIG
CIKLDVKDAIIKGDLSGVGDVDPYYTVSLNRRVLYKSIYHSDTDHPIFDNSTYVPIFS
PNQILTLEFHDYQKIGKDRFIGSVQIPTSNVFKKDPKSGKYVGNNGKEEISKLKLKDH
EHKVTESIVNVSTTFIPINLVYSPEELVNVEKLEKELKEKKKKFEATQEENEQEMEKN
PKEWEVAEIEDPFDSDEKKINRKAKLSLNELIKQKSGILSMQILEGTLSPSSAYLEIL
ADDISYPVFICMKPSQGKLNSEMANIFIRDLNYSKLHFRVSKKHIAKDSDDVISETSY
STLKLLKQAYEEPMWLNFNGSKMKVRFLYTPTSVKLPSSESVEDTGYLNIKLISGHGL
KSADRNGYSDPFVHIFVNDKKVFKSNIKKKTLDPVWNEDAKIPILSRSKNQVIFNVLD
WDRAGDNDDLGQASLDVSSLEVGKTYNWNLNLNTQGSIKLQGSFNPEYIKPSFDIVKG
GITDKPMKIASGAAHATVGIAGTGIGAATGVATGGLKKGGHLLKSLGGNPMKRSKSSN
GNESNGAKKSSEKKSFDRRSPSNLNSTSVTPRASLDYDPSVPNTSYAPVQSASPVVKP
TDNTSSSSNKKDTPSSNSRGHSRASSFARTLAPHGTYNGFITVVAAENVAKHVQIKIS
LTQGGRLKHIYKTKSQKANNDGVAVFDEECSFKASPEANLVLGAISHQRLSRDKDLGI
AQINLGDPQIQQDGQISVKLGDGHLIVKINYGKDKNGQVPPVPEVPQEYTQ"
gene complement(<129749..>131572)
/gene="COG8"
/locus_tag="YML071C"
/gene_synonym="DOR1"
/db_xref="GeneID:854904"
mRNA complement(<129749..>131572)
/gene="COG8"
/locus_tag="YML071C"
/gene_synonym="DOR1"
/product="Golgi transport complex subunit COG8"
/transcript_id="NM_001182430.1"
/db_xref="GeneID:854904"
CDS complement(129749..131572)
/gene="COG8"
/locus_tag="YML071C"
/gene_synonym="DOR1"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0006891
intra-Golgi vesicle-mediated transport [PMID:11703943]"
/experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi
transport complex [PMID:11703943]"
/experiment="EXISTENCE:mutant phenotype:GO:0032258
cytoplasm to vacuole transport by the Cvt pathway
[PMID:20065092]"
/note="Component of the conserved oligomeric Golgi
complex; a cytosolic tethering complex (Cog1p through
Cog8p) that functions in protein trafficking to mediate
fusion of transport vesicles to Golgi compartments"
/codon_start=1
/product="Golgi transport complex subunit COG8"
/protein_id="NP_013640.1"
/db_xref="GeneID:854904"
/db_xref="SGD:S000004536"
/translation="MELILNSLISDDLTEEQKRLSLDFLQDILQSNTKDYESYFSSRA
VPGSITEDIAEIDAELSALDRKIRKTLLDNTSQIIGNILENDDRAQLDDIAKSLEQLW
ELDTNINKAADRNVTNDDINNESVSIDDFLEDDKEDNDTGRIMTTESNNLARKKKEDE
FHKALSRLRNRISTKEDDKDDIRSDTLVTVLENLDSITDLMELPFLARTCIRTGHYQE
AVMLYTHTTSLRSRFPGSTIVDEVCEKVLNEISTTMLSGLVKLLSTNVSVNSLKKILQ
YLNSIPPFDGKTNKSLLSVFLAMRYKFITDEIASYPLDVESSNESLIEMMVKRKIEVL
REHVYMSLNVFLKSFLYDTNDLEIPFPEELESTVLRINGTNEEKEIEEKEKETKKEEY
QKQDSVANNEEDVTENKSIEDVQEEVQGKVEGEDDGAERKTENEIENETVNKTEDKAE
KEKEEEVNTKDNKAEKEEEEINKVEVTPEEPSKSIDNKAEKEEEEINKVEVTPEEPSK
KIRTSKRENKIPTNAVMLQFVDKCITYVLKDLTRGLNSIKLSDSVCLQLVYCSFRLCD
LNRNYHHLFLKKINDTSLFTTEQLARAIDKRAELASKYIYS"
gene complement(131825..131896)
/locus_tag="YNCM0004C"
/db_xref="GeneID:854905"
tRNA complement(131825..131896)
/locus_tag="YNCM0004C"
/product="tRNA-Arg"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE
analysis; one of 11 nuclear tRNA genes containing the
tDNA-anticodon UCU (converted to mcm5-UCU in the mature
tRNA), decodes AGA codons into arginine, one of 19 nuclear
tRNAs for arginine"
/db_xref="GeneID:854905"
/db_xref="SGD:S000006718"
repeat_region complement(131989..132321)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007101"
gene <133475..>135229
/gene="DAK1"
/locus_tag="YML070W"
/db_xref="GeneID:854932"
mRNA <133475..>135229
/gene="DAK1"
/locus_tag="YML070W"
/product="dihydroxyacetone kinase"
/transcript_id="NM_001182429.1"
/db_xref="GeneID:854932"
CDS 133475..135229
/gene="DAK1"
/locus_tag="YML070W"
/EC_number="2.7.1.28"
/EC_number="2.7.1.29"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0004371
glycerone kinase activity [PMID:12401799]"
/experiment="EXISTENCE:genetic interaction:GO:0061610
glycerol to glycerone phosphate metabolic process
[PMID:22979944]"
/experiment="EXISTENCE:mutant phenotype:GO:0004371
glycerone kinase activity [PMID:12401799]"
/note="Dihydroxyacetone kinase; required for
detoxification of dihydroxyacetone (DHA); involved in
stress adaptation"
/codon_start=1
/product="dihydroxyacetone kinase"
/protein_id="NP_013641.1"
/db_xref="GeneID:854932"
/db_xref="SGD:S000004535"
/translation="MSAKSFEVTDPVNSSLKGFALANPSITLVPEEKILFRKTDSDKI
ALISGGGSGHEPTHAGFIGKGMLSGAVVGEIFASPSTKQILNAIRLVNENASGVLLIV
KNYTGDVLHFGLSAERARALGINCRVAVIGDDVAVGREKGGMVGRRALAGTVLVHKIV
GAFAEEYSSKYGLDGTAKVAKIINDNLVTIGSSLDHCKVPGRKFESELNEKQMELGMG
IHNEPGVKVLDPIPSTEDLISKYMLPKLLDPNDKDRAFVKFDEDDEVVLLVNNLGGVS
NFVISSITSKTTDFLKENYNITPVQTIAGTLMTSFNGNGFSITLLNATKATKALQSDF
EEIKSVLDLLNAFTNAPGWPIADFEKTSAPSVNDDLLHNEVTAKAVGTYDFDKFAEWM
KSGAEQVIKSEPHITELDNQVGDGDCGYTLVAGVKGITENLDKLSKDSLSQAVAQISD
FIEGSMGGTSGGLYSILLSGFSHGLIQVCKSKDEPVTKEIVAKSLGIALDTLYKYTKA
RKGSSTMIDALEPFVKEFTASKDFNKAVKAAEEGAKSTATFEAKFGRASYVGDSSQVE
DPGAVGLCEFLKGVQSAL"
gene <135500..>137158
/gene="POB3"
/locus_tag="YML069W"
/db_xref="GeneID:854933"
mRNA <135500..>137158
/gene="POB3"
/locus_tag="YML069W"
/product="FACT complex subunit POB3"
/transcript_id="NM_001182428.1"
/db_xref="GeneID:854933"
CDS 135500..137158
/gene="POB3"
/locus_tag="YML069W"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:10413469]"
/experiment="EXISTENCE:direct assay:GO:0003682 chromatin
binding [PMID:10413469]"
/experiment="EXISTENCE:direct assay:GO:0006325 chromatin
organization [PMID:15082784|PMID:19683499]"
/experiment="EXISTENCE:direct assay:GO:0031298 replication
fork protection complex [PMID:16531994]"
/experiment="EXISTENCE:direct assay:GO:0031491 nucleosome
binding [PMID:11432837]"
/experiment="EXISTENCE:direct assay:GO:0035101 FACT
complex [PMID:9705338]"
/experiment="EXISTENCE:direct assay:GO:0042393 histone
binding [PMID:18089575]"
/experiment="EXISTENCE:direct assay:GO:0045899 positive
regulation of RNA polymerase II transcription
preinitiation complex assembly [PMID:15987999]"
/experiment="EXISTENCE:genetic interaction:GO:0006261
DNA-templated DNA replication [PMID:10924459]"
/experiment="EXISTENCE:mutant phenotype:GO:0006261
DNA-templated DNA replication [PMID:10924459]"
/experiment="EXISTENCE:physical interaction:GO:0006261
DNA-templated DNA replication [PMID:9199353]"
/note="Subunit of the heterodimeric FACT complex
(Spt16p-Pob3p); FACT associates with chromatin via
interaction with Nhp6Ap and Nhp6Bp, and reorganizes
nucleosomes to facilitate access to DNA by RNA and DNA
polymerases; protein abundance increases in response to
DNA replication stress"
/codon_start=1
/product="FACT complex subunit POB3"
/protein_id="NP_013642.1"
/db_xref="GeneID:854933"
/db_xref="SGD:S000004534"
/translation="MSTDFDRIYLNQSKFSGRFRIADSGLGWKISTSGGSAANQARKP
FLLPATELSTVQWSRGCRGYDLKINTKNQGVIQLDGFSQDDYNLIKNDFHRRFNIQVE
QREHSLRGWNWGKTDLARNEMVFALNGKPTFEIPYARINNTNLTSKNEVGIEFNIQDE
EYQPAGDELVEMRFYIPGVIQTNVDENMTKKEESSNEVVPKKEDGAEGEDVQMAVEEK
SMAEAFYEELKEKADIGEVAGDAIVSFQDVFFTTPRGRYDIDIYKNSIRLRGKTYEYK
LQHRQIQRIVSLPKADDIHHLLVLAIEPPLRQGQTTYPFLVLQFQKDEETEVQLNLED
EDYEENYKDKLKKQYDAKTHIVLSHVLKGLTDRRVIVPGEYKSKYDQCAVSCSFKANE
GYLYPLDNAFFFLTKPTLYIPFSDVSMVNISRAGQTSTSSRTFDLEVVLRSNRGSTTF
ANISKEEQQLLEQFLKSKNLRVKNEDREVQERLQTALGSDSDEEDINMGSAGEDDESV
DEDFQVSSDNDADEVAEEFDSDAALSDAEGGSDEERPSKKPKVE"
rep_origin 137300..137548
/note="ARS1307; Autonomously Replicating Sequence"
/db_xref="SGD:S000118367"
gene <137550..>138944
/gene="ITT1"
/locus_tag="YML068W"
/db_xref="GeneID:854934"
mRNA <137550..>138944
/gene="ITT1"
/locus_tag="YML068W"
/product="RBR-type E3 ubiquitin transferase"
/transcript_id="NM_001182427.1"
/db_xref="GeneID:854934"
CDS 137550..138944
/gene="ITT1"
/locus_tag="YML068W"
/EC_number="2.3.2.31"
/experiment="EXISTENCE:mutant phenotype:GO:0006449
regulation of translational termination [PMID:11570975]"
/note="Protein that modulates the efficiency of
translation termination; interacts with translation
release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro,
contains a zinc finger domain characteristic of the TRIAD
class of proteins"
/codon_start=1
/product="RBR-type E3 ubiquitin transferase"
/protein_id="NP_013643.1"
/db_xref="GeneID:854934"
/db_xref="SGD:S000004533"
/translation="MALTQFENDLEILRDMYPELEMKSVKVEEEGEFPQRINGKLLFK
ISLLADVNIEFGEQHMLLSNLSNECVEFTIYSCHYPDIRRCVVMDIKSLWISTDEKKM
LIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPNGIRKCLTQDQYDL
FKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAM
IQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEK
MFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCHFVFCFDCLHAWHGY
NNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAI
KKEGSNLQRCPKCKVVVERSEGCNKMKCEVCGTLFCFICGVLLYPEDPYEHFREAYSG
CYGRLFEGMPGTET"
gene complement(<139063..>140214)
/gene="ERV41"
/locus_tag="YML067C"
/db_xref="GeneID:854935"
mRNA complement(join(<139063..140090,140184..>140214))
/gene="ERV41"
/locus_tag="YML067C"
/product="Erv41p"
/transcript_id="NM_001182426.1"
/db_xref="GeneID:854935"
CDS complement(join(139063..140090,140184..140214))
/gene="ERV41"
/locus_tag="YML067C"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:11157978]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:11157978]"
/experiment="EXISTENCE:direct assay:GO:0030134
COPII-coated ER to Golgi transport vesicle
[PMID:11157978]"
/experiment="EXISTENCE:genetic interaction:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:11157978]"
/note="Protein localized to COPII-coated vesicles; forms a
complex with Erv46p; involved in the membrane fusion stage
of transport; has homology to human ERGIC2 (PTX1) protein"
/codon_start=1
/product="Erv41p"
/protein_id="NP_013644.1"
/db_xref="GeneID:854935"
/db_xref="SGD:S000004532"
/translation="MAGLKTFDAFPKTEEQYKKKSTKGGLTSLLTYLFLLFIAWTEFG
EYFGGYIDQQYVVDSQVRDTVQINMDIYVNTKCDWLQINVRDQTMDRKLVLEELQLEE
MPFFIPYDTKVNDINEIITPELDEILGEAIPAEFREKLDTRSFFDESDPNKAHLPEFN
GCHVFGSIPVNRVSGELQITAKSLGYVASRKAPLEELKFNHVINEFSFGDFYPYIDNP
LDNTAQFNQDEPLTTYVYYTSVVPTLFKKLGAEVDTNQYSVNDYRYLYKDVAAKGDKM
PGIFFKYNFEPLSIVVSDVRLSFIQFLVRLVAICSFLVYCASWIFTLLDMALITIMGP
KWSLRYQPDDKTKGILDR"
gene complement(<140424..>141533)
/gene="SMA2"
/locus_tag="YML066C"
/db_xref="GeneID:854936"
mRNA complement(<140424..>141533)
/gene="SMA2"
/locus_tag="YML066C"
/product="Sma2p"
/transcript_id="NM_001182425.1"
/db_xref="GeneID:854936"
CDS complement(140424..141533)
/gene="SMA2"
/locus_tag="YML066C"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005628 prospore
membrane [PMID:17298976|PMID:18756268|PMID:24390141]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:17298976]"
/experiment="EXISTENCE:mutant phenotype:GO:0032120
ascospore-type prospore membrane formation
[PMID:11470404]"
/experiment="EXISTENCE:mutant phenotype:GO:0070583 spore
membrane bending pathway [PMID:18756268]"
/note="Meiosis-specific prospore membrane protein;
required to produce bending force necessary for proper
assembly of the prospore membrane during sporulation"
/codon_start=1
/product="Sma2p"
/protein_id="NP_013645.1"
/db_xref="GeneID:854936"
/db_xref="SGD:S000004531"
/translation="MLFPKRLIVWGVLLILSLSQFVLYLPATTCTNSKGLRLCAPQFT
ITVIGGSSTANEFIASVREFLRLISYLTIDMGWSNEFTDPSVYEDENLVDTFQPDKVF
ELNYFGFCKRSNKSKVYCTSNENYGMDVLEVLVRDVGIQLGNISTTRSNETKKFGDSL
VLTYRLALTSIRDFLKHDKHTGNALSKALIGSPDPNVKGVSPTKNYLKGVNLAFILMM
FNGMVFYFAVLEIIVGFLSICVVSAFGGALSVGKRHRLFPMLLKSSSSILVVIATLTI
LCNIVYLIALKTLEPEEVTDVGSDNAAVHTTGWELLKVNVGSGFIMGLARYAIQWVLL
VLAFLAANHYKAKPKKSDKYTEDTSNSPSPDLMEK"
gene <142210..>144954
/gene="ORC1"
/locus_tag="YML065W"
/db_xref="GeneID:854937"
mRNA <142210..>144954
/gene="ORC1"
/locus_tag="YML065W"
/product="origin recognition complex subunit 1"
/transcript_id="NM_001182424.1"
/db_xref="GeneID:854937"
CDS 142210..144954
/gene="ORC1"
/locus_tag="YML065W"
/experiment="EXISTENCE:direct assay:GO:0003682 chromatin
binding [PMID:11168584]"
/experiment="EXISTENCE:direct assay:GO:0003688 DNA
replication origin binding [PMID:16824194]"
/experiment="EXISTENCE:direct assay:GO:0005524 ATP binding
[PMID:17825064]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11168584]"
/experiment="EXISTENCE:direct assay:GO:0005656 nuclear
pre-replicative complex [PMID:16824194|PMID:9335335]"
/experiment="EXISTENCE:direct assay:GO:0005664 nuclear
origin of replication recognition complex [PMID:9372948]"
/experiment="EXISTENCE:direct assay:GO:0006267
pre-replicative complex assembly involved in nuclear cell
cycle DNA replication [PMID:16824194]"
/experiment="EXISTENCE:direct assay:GO:0030466 silent
mating-type cassette heterochromatin formation
[PMID:12897051|PMID:16581798]"
/experiment="EXISTENCE:direct assay:GO:0031261 DNA
replication preinitiation complex [PMID:9554851]"
/experiment="EXISTENCE:direct assay:GO:0031491 nucleosome
binding [PMID:31263106]"
/experiment="EXISTENCE:direct assay:GO:0043007 maintenance
of rDNA [PMID:31263106]"
/experiment="EXISTENCE:genetic interaction:GO:0030466
silent mating-type cassette heterochromatin formation
[PMID:16581798]"
/experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP
binding [PMID:9038340]"
/experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear
origin of replication recognition complex [PMID:9372948]"
/experiment="EXISTENCE:mutant phenotype:GO:0006267
pre-replicative complex assembly involved in nuclear cell
cycle DNA replication [PMID:9335335]"
/experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA
replication initiation [PMID:16716188]"
/experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP
hydrolysis activity [PMID:9038340]"
/experiment="EXISTENCE:mutant phenotype:GO:0034728
nucleosome organization [PMID:37020028]"
/note="Largest subunit of the origin recognition complex;
involved in directing DNA replication by binding to
replication origins; also involved in transcriptional
silencing; exhibits ATPase activity; role in chromatin
organization at replication origins, along with chromatin
remodellers; ORC1 has a paralog, SIR3, that arose from the
whole genome duplication"
/codon_start=1
/product="origin recognition complex subunit 1"
/protein_id="NP_013646.1"
/db_xref="GeneID:854937"
/db_xref="SGD:S000004530"
/translation="MAKTLKDLQGWEIITTDEQGNIIDGGQKRLRRRGAKTEHYLKRS
SDGIKLGRGDSVVMHNEAAGTYSVYMIQELRLNTLNNVVELWALTYLRWFEVNPLAHY
RQFNPDANILNRPLNYYNKLFSETANKNELYLTAELAELQLFNFIRVANVMDGSKWEV
LKGNVDPERDFTVRYICEPTGEKFVDINIEDVKAYIKKVEPREAQEYLKDLTLPSKKK
EIKRGPQKKDKATQTAQISDAETRATDITDNEDGNEDESSDYESPSDIDVSEDMDSGE
ISADELEEEEDEEEDEDEEEKEARHTNSPRKRGRKIKLGKDDIDASVQPPPKKRGRKP
KDPSKPRQMLLISSCRANNTPVIRKFTKKNVARAKKKYTPFSKRFKSIAAIPDLTSLP
EFYGNSSELMASRFENKLKTTQKHQIVETIFSKVKKQLNSSYVKEEILKSANFQDYLP
ARENEFASIYLSAYSAIESDSATTIYVAGTPGVGKTLTVREVVKELLSSSAQREIPDF
LYVEINGLKMVKPTDCYETLWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLLD
ELDAMVTKSQDIMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMF
TGYTHEELKNIIDLRLKGLNDSFFYVDTKTGNAILIDAAGNDTTVKQTLPEDVRKVRL
RMSADAIEIASRKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGKTVIEDENE
EQIYDDEDKDLIESNKAKDDNDDDDDNDGVQTVHITHVMKALNETLNSHVITFMTRLS
FTAKLFIYALLNLMKKNGSQEQELGDIVDEIKLLIEVNGSNKFVMEIAKTLFQQGSDN
ISEQLRIISWDFVLNQLLDAGILFKQTMKNDRICCVKLNISVEEAKRAMNEDETLRNL
"
gene complement(<145139..>145876)
/gene="TEM1"
/locus_tag="YML064C"
/db_xref="GeneID:854938"
mRNA complement(<145139..>145876)
/gene="TEM1"
/locus_tag="YML064C"
/product="Ras family GTPase TEM1"
/transcript_id="NM_001182423.1"
/db_xref="GeneID:854938"
CDS complement(145139..145876)
/gene="TEM1"
/locus_tag="YML064C"
/experiment="EXISTENCE:direct assay:GO:0003924 GTPase
activity [PMID:12048186|PMID:25658911]"
/experiment="EXISTENCE:direct assay:GO:0005816 spindle
pole body [PMID:19154724]"
/experiment="EXISTENCE:direct assay:GO:0023056 positive
regulation of signaling [PMID:32074005]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:25658911]"
/experiment="EXISTENCE:mutant phenotype:GO:0031536
positive regulation of exit from mitosis [PMID:21321099]"
/experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic
spindle orientation checkpoint signaling [PMID:25658911]"
/experiment="EXISTENCE:mutant phenotype:GO:0040001
establishment of mitotic spindle localization
[PMID:21937712]"
/experiment="EXISTENCE:mutant phenotype:GO:1902542
regulation of protein localization to mitotic spindle pole
body [PMID:25658911]"
/experiment="EXISTENCE:mutant phenotype:GO:1904750
negative regulation of protein localization to nucleolus
[PMID:10219244]"
/note="GTPase involved in initiation of Mitotic Exit
Network (MEN); GTP-binding protein of the Ras superfamily;
accumulates at daughter spindle pole body and activates
MEN kinase cascade; controls actomyosin and septin
dynamics during cytokinesis"
/codon_start=1
/product="Ras family GTPase TEM1"
/protein_id="NP_013647.1"
/db_xref="GeneID:854938"
/db_xref="SGD:S000004529"
/translation="MATPSTGANNSIPAVRNQVEVQVGLVGDAQVGKTSLMVKYVQNI
YDKEYTQTLGVNFLKRKVSIRSTDIIFSIMDLGGQREFINMLPIATVGSSVIIFLFDL
TRPETLSSIKEWYRQAYGLNDSAIPILVGTKYDLLIDLDPEYQEQISRTSMKYAQVMN
APLIFCSTAKSINIQKIFKIALAKIFNLTLTIPEINEIGDPLLIYKHLGGQQHRHHNK
SQDRKSHNIRKPSSSPSSKAPSPGVNT"
gene <146482..>147249
/gene="RPS1B"
/locus_tag="YML063W"
/gene_synonym="PLC2; RP10B"
/db_xref="GeneID:854939"
mRNA <146482..>147249
/gene="RPS1B"
/locus_tag="YML063W"
/gene_synonym="PLC2; RP10B"
/product="ribosomal 40S subunit protein S1B"
/transcript_id="NM_001182422.1"
/db_xref="GeneID:854939"
CDS 146482..147249
/gene="RPS1B"
/locus_tag="YML063W"
/gene_synonym="PLC2; RP10B"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:12150911]"
/experiment="EXISTENCE:genetic interaction:GO:0000462
maturation of SSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]"
/note="Ribosomal protein of the small (40S) subunit;
homologous to mammalian ribosomal protein S3A, no
bacterial homolog; RPS1B has a paralog, RPS1A, that arose
from the whole genome duplication"
/codon_start=1
/product="ribosomal 40S subunit protein S1B"
/protein_id="NP_013648.1"
/db_xref="GeneID:854939"
/db_xref="SGD:S000004528"
/translation="MAVGKNKRLSRGKKGLKKKVVDPFTRKEWFDIKAPSTFENRNVG
KTLVNKSTGLKNASDALKGRVVEVCLADLQGSEDHSFRKVKLRVDEVQGKNLLTNFHG
MDFTTDKLRSMVRKWQTLIEANVTVKTSDDYVLRIFAIAFTRKQANQVKRHSYAQSSH
IRAIRKVISEILTREVQNSTLAQLTSKLIPEVINKEIENATKDIFPLQNIHVRKVKLL
KQPKFDVGALMALHGEGSGEEKGKKVSGFKDEVLETV"
gene complement(<147505..>148683)
/gene="MFT1"
/locus_tag="YML062C"
/gene_synonym="MFT52"
/db_xref="GeneID:854940"
mRNA complement(<147505..>148683)
/gene="MFT1"
/locus_tag="YML062C"
/gene_synonym="MFT52"
/product="Mft1p"
/transcript_id="NM_001182421.1"
/db_xref="GeneID:854940"
CDS complement(147505..148683)
/gene="MFT1"
/locus_tag="YML062C"
/gene_synonym="MFT52"
/experiment="EXISTENCE:direct assay:GO:0000781 chromosome,
telomeric region [PMID:24084588]"
/experiment="EXISTENCE:direct assay:GO:0003676 nucleic
acid binding [PMID:12093753]"
/experiment="EXISTENCE:mutant phenotype:GO:0000445 THO
complex part of transcription export complex
[PMID:11979277]"
/experiment="EXISTENCE:mutant phenotype:GO:0000446
nucleoplasmic THO complex [PMID:11060033]"
/experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA
recombination [PMID:11060033]"
/experiment="EXISTENCE:mutant phenotype:GO:0006368
transcription elongation by RNA polymerase II
[PMID:12093753]"
/experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA
export from nucleus [PMID:11979277]"
/experiment="EXISTENCE:mutant phenotype:GO:0060090
molecular adaptor activity [PMID:16908536]"
/note="Subunit of the THO complex; THO is a nuclear
complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that
is involved in transcription elongation and mitotic
recombination; involved in telomere maintenance"
/codon_start=1
/product="Mft1p"
/protein_id="NP_013649.1"
/db_xref="GeneID:854940"
/db_xref="SGD:S000004527"
/translation="MPLSQKQIDQVRTKVHYSEVDTPFNKYLDILGKVTKLTGSIING
TLSNDDSKIEKLTEQNISQLKESAHLRFLDLQSSIDTKKVADENWETCQQETLAKLEN
LKDKLPDIKSIHSKLLLRIGKLQGLYDSVQVINREVEGLSEGRTSLVVTRAEWEKELG
TDLVKFLIEKNYLKLVDPGLKKDSSEERYRIYDDFSKGPKELESINASMKSDIENVRQ
EVSSYKEKWLRDAEIFGKITSIFKEELLKRDGLLNEAEGDNIDEDYESDEDEERKERF
KRQRSMVEVNTIENVDEKEESDHEYDDQEDEENEEEDDMEVDVEDIKEDNEVDGESSQ
QEDNSRQGNNEETDKETGVIEEPDAVNDAEEADSDHSSRKLGGTTSDFSASSSVEEVK
"
gene complement(<148953..>151532)
/gene="PIF1"
/locus_tag="YML061C"
/gene_synonym="TST1"
/db_xref="GeneID:854941"
mRNA complement(<148953..>151532)
/gene="PIF1"
/locus_tag="YML061C"
/gene_synonym="TST1"
/product="DNA helicase PIF1"
/transcript_id="NM_001182420.1"
/db_xref="GeneID:854941"
CDS complement(148953..151532)
/gene="PIF1"
/locus_tag="YML061C"
/gene_synonym="TST1"
/EC_number="3.6.4.12"
/experiment="EXISTENCE:direct assay:GO:0003678 DNA
helicase activity [PMID:8253734]"
/experiment="EXISTENCE:direct assay:GO:0003697
single-stranded DNA binding [PMID:23596008]"
/experiment="EXISTENCE:direct assay:GO:0005657 replication
fork [PMID:26411679]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:1849081]"
/experiment="EXISTENCE:direct assay:GO:0006268 DNA
unwinding involved in DNA replication [PMID:31744872]"
/experiment="EXISTENCE:direct assay:GO:0010521 telomerase
inhibitor activity [PMID:16121131]"
/experiment="EXISTENCE:direct assay:GO:0019237 centromeric
DNA binding [PMID:30442759]"
/experiment="EXISTENCE:direct assay:GO:0031966
mitochondrial membrane [PMID:20655619]"
/experiment="EXISTENCE:direct assay:GO:0032211 negative
regulation of telomere maintenance via telomerase
[PMID:16121131]"
/experiment="EXISTENCE:direct assay:GO:0035861 site of
double-strand break [PMID:33823531]"
/experiment="EXISTENCE:direct assay:GO:0042162 telomeric
DNA binding [PMID:30068549]"
/experiment="EXISTENCE:direct assay:GO:0043596 nuclear
replication fork [PMID:26981397]"
/experiment="EXISTENCE:direct assay:GO:0051880
G-quadruplex DNA binding [PMID:23657261]"
/experiment="EXISTENCE:genetic interaction:GO:0000722
telomere maintenance via recombination [PMID:23390378]"
/experiment="EXISTENCE:genetic interaction:GO:0071932
replication fork reversal [PMID:26411679]"
/experiment="EXISTENCE:mutant phenotype:GO:0000002
mitochondrial genome maintenance [PMID:15907372]"
/experiment="EXISTENCE:mutant phenotype:GO:0000723
telomere maintenance [PMID:10926538]"
/experiment="EXISTENCE:mutant phenotype:GO:0000727
double-strand break repair via break-induced replication
[PMID:24025772]"
/experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA
recombination [PMID:1849081]"
/experiment="EXISTENCE:mutant phenotype:GO:0010521
telomerase inhibitor activity [PMID:16121131]"
/experiment="EXISTENCE:mutant phenotype:GO:0019985
translesion synthesis [PMID:30107417]"
/experiment="EXISTENCE:mutant phenotype:GO:0032211
negative regulation of telomere maintenance via telomerase
[PMID:16121131]"
/experiment="EXISTENCE:mutant phenotype:GO:0044806
G-quadruplex DNA unwinding [PMID:23657261]"
/experiment="EXISTENCE:mutant phenotype:GO:0051276
chromosome organization [PMID:8287473]"
/note="DNA helicase, potent G-quadruplex DNA
binder/unwinder; possesses strand annealing activity;
promotes DNA synthesis during break-induced replication;
involved in crossover recombination; works with Hrq1p to
maintain telomere length homeostasis; translation from
different start sites produces mitochondrial (DNA repair
and recombination) and nuclear (catalytic inhibitor of
telomerase) isoforms; mutations affect Zn, Fe homeostasis;
regulated by Rad53p-dependent phosphorylation in rho0
cells"
/codon_start=1
/product="DNA helicase PIF1"
/protein_id="NP_013650.1"
/db_xref="GeneID:854941"
/db_xref="SGD:S000004526"
/translation="MPKWIRSTLNHIIPRRPFICSFNSFLLLKNVSHAKLSFSMSSRG
FRSNNFIQAQLKHPSILSKEDLDLLSDSDDWEEPDCIQLETEKQEKKIITDIHKEDPV
DKKPMRDKNVMNFINKDSPLSWNDMFKPSIIQPPQLISENSFDQSSQKKSRSTGFKNP
LRPALKKESSFDELQNNSISQERSLEMINENEKKKMQFGEKIAVLTQRPSFTELQNDQ
DDSNLNPHNGVKVKIPICLSKEQESIIKLAENGHNIFYTGSAGTGKSILLREMIKVLK
GIYGRENVAVTASTGLAACNIGGITIHSFAGIGLGKGDADKLYKKVRRSRKHLRRWEN
IGALVVDEISMLDAELLDKLDFIARKIRKNHQPFGGIQLIFCGDFFQLPPVSKDPNRP
TKFAFESKAWKEGVKMTIMLQKVFRQRGDVKFIDMLNRMRLGNIDDETEREFKKLSRP
LPDDEIIPAELYSTRMEVERANNSRLSKLPGQVHIFNAIDGGALEDEELKERLLQNFL
APKELHLKVGAQVMMVKNLDATLVNGSLGKVIEFMDPETYFCYEALTNDPSMPPEKLE
TWAENPSKLKAAMEREQSDGEESAVASRKSSVKEGFAKSDIGEPVSPLDSSVFDFMKR
VKTDDEVVLENIKRKEQLMQTIHQNSAGKRRLPLVRFKASDMSTRMVLVEPEDWAIED
ENEKPLVSRVQLPLMLAWSLSIHKSQGQTLPKVKVDLRRVFEKGQAYVALSRAVSREG
LQVLNFDRTRIKAHQKVIDFYLTLSSAESAYKQLEADEQVKKRKLDYAPGPKYKAKSK
SKSNSPAPISATTQSNNGIAAMLQRHSRKRFQLKKESNSNQVHSLVSDEPRGQDTEDH
ILE"
gene <151871..>153001
/gene="OGG1"
/locus_tag="YML060W"
/db_xref="GeneID:854942"
mRNA <151871..>153001
/gene="OGG1"
/locus_tag="YML060W"
/product="8-oxoguanine glycosylase OGG1"
/transcript_id="NM_001182419.1"
/db_xref="GeneID:854942"
CDS 151871..153001
/gene="OGG1"
/locus_tag="YML060W"
/EC_number="4.2.99.18"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11239005]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:11239005]"
/experiment="EXISTENCE:direct assay:GO:0006285
base-excision repair, AP site formation [PMID:8643552]"
/experiment="EXISTENCE:direct assay:GO:0008534 oxidized
purine nucleobase lesion DNA N-glycosylase activity
[PMID:8643552]"
/experiment="EXISTENCE:genetic interaction:GO:0070987
error-free translesion synthesis [PMID:19264809]"
/experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
repair [PMID:11239005]"
/experiment="EXISTENCE:mutant phenotype:GO:0007004
telomere maintenance via telomerase [PMID:19942858]"
/note="Nuclear and mitochondrial glycosylase/lyase;
specifically excises 7,8-dihydro-8-oxoguanine residues
located opposite cytosine or thymine residues in DNA,
repairs oxidative damage to mitochondrial DNA, contributes
to UVA resistance"
/codon_start=1
/product="8-oxoguanine glycosylase OGG1"
/protein_id="NP_013651.1"
/db_xref="GeneID:854942"
/db_xref="SGD:S000004525"
/translation="MSYKFGKLAINKSELCLANVLQAGQSFRWIWDEKLNQYSTTMKI
GQQEKYSVVILRQDEENEILEFVAVGDCGNQDALKTHLMKYFRLDVSLKHLFDNVWIP
SDKAFAKLSPQGIRILAQEPWETLISFICSSNNNISRITRMCNSLCSNFGNLITTIDG
VAYHSFPTSEELTSRATEAKLRELGFGYRAKYIIETARKLVNDKAEANITSDTTYLQS
ICKDAQYEDVREHLMSYNGVGPKVADCVCLMGLHMDGIVPVDVHVSRIAKRDYQISAN
KNHLKELRTKYNALPISRKKINLELDHIRLMLFKKWGSYAGWAQGVLFSKEIGGTSGS
TTTGTIKKRKWDMIKETEAIVTKQMKLKVELSDLHIKEAKID"
gene complement(<153219..>158258)
/gene="NTE1"
/locus_tag="YML059C"
/db_xref="GeneID:854943"
mRNA complement(<153219..>158258)
/gene="NTE1"
/locus_tag="YML059C"
/product="lysophospholipase"
/transcript_id="NM_001182418.1"
/db_xref="GeneID:854943"
CDS complement(153219..158258)
/gene="NTE1"
/locus_tag="YML059C"
/EC_number="3.1.1.5"
/experiment="EXISTENCE:direct assay:GO:0004622
lysophospholipase activity [PMID:15044461]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:15044461|PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0034638
phosphatidylcholine catabolic process [PMID:15044461]"
/experiment="EXISTENCE:mutant phenotype:GO:0071071
regulation of phospholipid biosynthetic process
[PMID:19841481]"
/note="Serine esterase; homolog of human neuropathy target
esterase (NTE); Nte1p-mediated phosphatidylcholine
turnover influences transcription factor Opi1p
localization, affecting transcriptional regulation of
phospholipid biosynthesis genes"
/codon_start=1
/product="lysophospholipase"
/protein_id="NP_013652.1"
/db_xref="GeneID:854943"
/db_xref="SGD:S000004524"
/translation="MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQI
ISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQF
TLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQ
SANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVF
HDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDG
LDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNTVKPG
NPLTSLVSILNLFTHSMSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTN
STNSFPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHV
TFQTAHDYLGLTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKP
KNSNASSKLKKPPKAKPSDGIIQSLKIANANANTSSNSLSLKPEFTHHPSSRHVVLGS
RDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNAS
VHSKKFSSLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNLLPTTSFS
AAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYSRRPSN
ASFLMSPHCTPSDISVASSFASPQTQPTMLRILPKEYTISNKRHNKSKSQDKKKPRAY
KEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYIISGKVNVTTNSSS
SVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKS
DVYVGFLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFS
QGDSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTA
MNRYSTIVAVRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGDRTVPALTGDP
LSIKENDFTSLIPPTKASYSSSLSHKPQNITSGTITFRTITILPITSGLPVEAFAMKL
VQAFKQVGRTTIGLNQRTTLTHLGRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPV
KSNWTRTCIAQGDCILLLADARSPSAEIGEYEKLLLNSKTTARTELILLHPERYVEPG
LTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMHVLNNGALALMDKLIQTEFSRKTQQ
NISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARILSGQAIGLVLGGG
GARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKFAGRIS
SIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHS
FGYAWRYIRASMSLAGLLPPLEENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSA
DDRTPMEYGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPG
VVYVRPPIEEYATLDFSKFEEIYHVGVDYGRIFLQGLIDDDKMPYIPGSQETTLNSQV
PEFLLHRRNSI"
gene <158760..>158966
/gene="HUG1"
/locus_tag="YML058W-A"
/db_xref="GeneID:854944"
mRNA <158760..>158966
/gene="HUG1"
/locus_tag="YML058W-A"
/product="Hug1p"
/transcript_id="NM_001184439.1"
/db_xref="GeneID:854944"
CDS 158760..158966
/gene="HUG1"
/locus_tag="YML058W-A"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:1990846
ribonucleoside-diphosphate reductase inhibitor activity
[PMID:25378334]"
/experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA
damage checkpoint signaling [PMID:10490641]"
/experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA
damage response [PMID:10490641]"
/note="Ribonucleotide reductase inhibitor; intrinsically
disordered protein that binds to and inhibits Rnr2p;
involved in the Mec1p-mediated checkpoint pathway;
transcription is induced by genotoxic stress and by
activation of the Rad53p pathway; protein abundance
increases in response to DNA replication stress"
/codon_start=1
/product="Hug1p"
/protein_id="NP_219498.1"
/db_xref="GeneID:854944"
/db_xref="SGD:S000007472"
/translation="MTMDQGLNPKQFFLDDVVLQDTLCSMSNRVNKSVKTGYLFPKDH
VPSANIIAVERRGGLSDIGKNTSN"
rep_origin 158887..159277
/note="ARS1307.5; Autonomously replicating sequence"
/db_xref="SGD:S000178152"
gene <159383..>159697
/gene="SML1"
/locus_tag="YML058W"
/db_xref="GeneID:854945"
mRNA <159383..>159697
/gene="SML1"
/locus_tag="YML058W"
/product="ribonucleotide reductase inhibiting protein
SML1"
/transcript_id="NM_001182417.1"
/db_xref="GeneID:854945"
CDS 159383..159697
/gene="SML1"
/locus_tag="YML058W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:1990846
ribonucleoside-diphosphate reductase inhibitor activity
[PMID:10593972|PMID:27155231]"
/experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA
damage response [PMID:9774971]"
/experiment="EXISTENCE:mutant phenotype:GO:0007005
mitochondrion organization [PMID:9774971]"
/note="Ribonucleotide reductase inhibitor; involved in
regulating dNTP production; regulated by Mec1p and Rad53p
during DNA damage and S phase; SML1 has a paralog, DIF1,
that arose from the whole genome duplication"
/codon_start=1
/product="ribonucleotide reductase inhibiting protein
SML1"
/protein_id="NP_013653.1"
/db_xref="GeneID:854945"
/db_xref="SGD:S000004523"
/translation="MQNSQDYFYAQNRCQQQQAPSTLRTVTMAEFRRVPLPPMAEVPM
LSTQNSMGSSASASASSLEMWEKDLEERLNSIDHDMNNNKFGSGELKSMFNQGKVEEM
DF"
gene <160180..>161994
/gene="CMP2"
/locus_tag="YML057W"
/gene_synonym="CNA2"
/db_xref="GeneID:854946"
mRNA <160180..>161994
/gene="CMP2"
/locus_tag="YML057W"
/gene_synonym="CNA2"
/product="calcineurin catalytic subunit A"
/transcript_id="NM_001182415.1"
/db_xref="GeneID:854946"
CDS 160180..161994
/gene="CMP2"
/locus_tag="YML057W"
/gene_synonym="CNA2"
/EC_number="3.1.3.16"
/experiment="EXISTENCE:direct assay:GO:0004723
calcium-dependent protein serine/threonine phosphatase
activity [PMID:1321337]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005955 calcineurin
complex [PMID:1321337]"
/experiment="EXISTENCE:mutant phenotype:GO:0000754
adaptation of signaling pathway by response to pheromone
involved in conjugation with cellular fusion
[PMID:1651503]"
/experiment="EXISTENCE:mutant phenotype:GO:0006873
intracellular monoatomic ion homeostasis [PMID:8798496]"
/note="Calcineurin A; one isoform (the other is Cna1p) of
the catalytic subunit of calcineurin, a
Ca++/calmodulin-regulated protein phosphatase which
regulates Crz1p (a stress-response transcription factor),
the other calcineurin subunit is CNB1; regulates the
function of Aly1p alpha-arrestin; CMP2 has a paralog,
CNA1, that arose from the whole genome duplication"
/codon_start=1
/product="calcineurin catalytic subunit A"
/protein_id="NP_013655.1"
/db_xref="GeneID:854946"
/db_xref="SGD:S000004521"
/translation="MSSDAIRNTEQINAAIKIIENKTERPQSSTTPIDSKASTVAAAN
STATETSRDLTQYTLDDGRVVSTNRRIMNKVPAITSHVPTDEELFQPNGIPRHEFLRD
HFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGG
DPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKN
EMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIP
SHGLMCDLLWADPIEEYDEVLDKDLTEEDIVNSKTMVPHHGKMAPSRDMFVPNSVRGC
SYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKTLGFPSLLTLFSAPNYLDT
YNNKAAILKYENNVMNIRQFNMTPHPYWLPDFMDVFTWSLPFVGEKVTEMLVAILNIC
TEDELENDTPVIEELVGTDKKLPQAGKSEATPQPATSASPKHASILDDEHRRKALRNK
ILAVAKVSRMYSVLREETNKVQFLKDHNSGVLPRGALSNGVKGLDEALSTFERARKHD
LINEKLPPSLDELKNENKKYYEKVWQKVHEHDAKNDSK"
gene complement(<162194..>164176)
/gene="IMD4"
/locus_tag="YML056C"
/db_xref="GeneID:854948"
mRNA complement(join(<162194..163308,163717..>164176))
/gene="IMD4"
/locus_tag="YML056C"
/product="IMP dehydrogenase IMD4"
/transcript_id="NM_001182414.1"
/db_xref="GeneID:854948"
CDS complement(join(162194..163308,163717..164176))
/gene="IMD4"
/locus_tag="YML056C"
/EC_number="1.1.1.205"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:23222640]"
/note="Inosine monophosphate dehydrogenase; catalyzes the
rate-limiting step in the de novo synthesis of GTP; member
of a four-gene family in S. cerevisiae, constitutively
expressed; IMD4 has a paralog, IMD3, that arose from the
whole genome duplication"
/codon_start=1
/product="IMP dehydrogenase IMD4"
/protein_id="NP_013656.1"
/db_xref="GeneID:854948"
/db_xref="SGD:S000004520"
/translation="MSAAPLDYKKALEHLKTYSSKDGLSVQELMDSTTRGGLTYNDFL
VLPGLVNFPSSAVSLQTKLTKKITLNTPFVSSPMDTVTEADMAIYMALLGGIGFIHHN
CTPKEQASMVKKVKMFENGFINSPIVISPTTTVGEVKVMKRKFGFSGFPVTEDGKCPG
KLVGLVTSRDIQFLEDDSLVVSEVMTKNPVTGIKGITLKEGNEILKQTKKGKLLIVDD
NGNLVSMLSRADLMKNQNYPLASKSATTKQLLCGAAIGTIEADKERLRLLVEAGLDVV
ILDSSQGNSVFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGS
ICITQEVMACGRPQGTAVYNVCQFANQFGVPCMADGGVQNIGHITKALALGSSTVMMG
GMLAGTTESPGEYFYKDGKRLKAYRGMGSIDAMQKTGNKGNASTSRYFSESDSVLVAQ
GVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCESLTSLKENVQNGEVRFEFRTASAQL
EGGVHNLHSYEKRLYN"
gene complement(163535..163620)
/gene="SNR54"
/locus_tag="YNCM0005C"
/db_xref="GeneID:9164960"
ncRNA complement(163535..163620)
/ncRNA_class="snoRNA"
/gene="SNR54"
/locus_tag="YNCM0005C"
/product="SNR54"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:10024243]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:10024243]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of small subunit (SSU) rRNA at position
A974"
/transcript_id="NR_132236.1"
/db_xref="GeneID:9164960"
/db_xref="SGD:S000006445"
gene <164790..>165326
/gene="SPC2"
/locus_tag="YML055W"
/gene_synonym="SPY1"
/db_xref="GeneID:854949"
mRNA <164790..>165326
/gene="SPC2"
/locus_tag="YML055W"
/gene_synonym="SPY1"
/product="signal peptidase complex subunit SPC2"
/transcript_id="NM_001182413.1"
/db_xref="GeneID:854949"
CDS 164790..165326
/gene="SPC2"
/locus_tag="YML055W"
/gene_synonym="SPY1"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005787 signal
peptidase complex [PMID:1846444|PMID:8910564]"
/experiment="EXISTENCE:genetic interaction:GO:0045047
protein targeting to ER [PMID:8910564]"
/experiment="EXISTENCE:mutant phenotype:GO:0006465 signal
peptide processing [PMID:10921929]"
/experiment="EXISTENCE:mutant phenotype:GO:0008233
peptidase activity [PMID:10921929]"
/experiment="EXISTENCE:mutant phenotype:GO:0045047 protein
targeting to ER [PMID:8910564]"
/experiment="EXISTENCE:mutant phenotype:GO:0120236
negative regulation of post-translational protein
targeting to membrane, translocation [PMID:32513868]"
/experiment="EXISTENCE:physical interaction:GO:0045047
protein targeting to ER [PMID:8910564]"
/note="Subunit of signal peptidase complex; complex
catalyzes cleavage of N-terminal signal sequences of
proteins targeted to the secretory pathway; inhibits
SRP-independent translocation into the ER with STE24;
homologous to mammalian SPC25; other members of the
complex are Spc1p, Spc1p, and Sec11p"
/codon_start=1
/product="signal peptidase complex subunit SPC2"
/protein_id="NP_013657.1"
/db_xref="GeneID:854949"
/db_xref="SGD:S000004519"
/translation="MSSAKPINVYSIPELNQALDEALPSVFARLNYERSYALLDAKLY
IGYSIAVVAGLSFFLDKKFERDQIVTYQKLLVGAYFVLSLLFWYFSRFIEKGTVYVGK
RRGTKEEIYVKTKFEKNEPLYLVELVQKKKGENSKKELKAKLEVNKVFNESGYLQNDA
YFKWFSEQHNVLDTKKNE"
gene complement(<165533..>167308)
/gene="CYB2"
/locus_tag="YML054C"
/gene_synonym="FCB2"
/db_xref="GeneID:854950"
mRNA complement(<165533..>167308)
/gene="CYB2"
/locus_tag="YML054C"
/gene_synonym="FCB2"
/product="L-lactate dehydrogenase (cytochrome)"
/transcript_id="NM_001182412.1"
/db_xref="GeneID:854950"
CDS complement(165533..167308)
/gene="CYB2"
/locus_tag="YML054C"
/gene_synonym="FCB2"
/EC_number="1.1.2.3"
/experiment="EXISTENCE:direct assay:GO:0004460 L-lactate
dehydrogenase (cytochrome) activity [PMID:3004948]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005758
mitochondrial intermembrane space
[PMID:3004948|PMID:6290489]"
/experiment="EXISTENCE:mutant phenotype:GO:0006089 lactate
metabolic process [PMID:8492799]"
/note="Cytochrome b2 (L-lactate cytochrome-c
oxidoreductase); component of the mitochondrial
intermembrane space, required for lactate utilization;
expression is repressed by glucose and anaerobic
conditions"
/codon_start=1
/product="L-lactate dehydrogenase (cytochrome)"
/protein_id="NP_013658.1"
/db_xref="GeneID:854950"
/db_xref="SGD:S000004518"
/translation="MLKYKPLLKISKNCEAAILRASKTRLNTIRAYGSTVPKSKSFEQ
DSRKRTQSWTALRVGAILAATSSVAYLNWHNGQIDNEPKLDMNKQKISPAEVAKHNKP
DDCWVVINGYVYDLTRFLPNHPGGQDVIKFNAGKDVTAIFEPLHAPNVIDKYIAPEKK
LGPLQGSMPPELVCPPYAPGETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTK
QAWAYYSSGANDEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSA
TALCKLGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQIQWYQLY
VNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFSNTKAGPKAMKKTNV
EESQGASRALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVL
SNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLKALCLGAKG
VGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTSIAELKPDLLDLSTLKAR
TVGVPNDVLYNEVYEGPTLTEFEDA"
gene complement(<167623..>167781)
/locus_tag="YML054C-A"
/db_xref="GeneID:1466497"
mRNA complement(<167623..>167781)
/locus_tag="YML054C-A"
/product="uncharacterized protein"
/transcript_id="NM_001184571.1"
/db_xref="GeneID:1466497"
CDS complement(167623..167781)
/locus_tag="YML054C-A"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878139.1"
/db_xref="GeneID:1466497"
/db_xref="SGD:S000028573"
/translation="MIPFPAQHEIFHAYIGRITPHSSRCIANMWHSAHFFHENSLSIM
KTLVPWTL"
repeat_region complement(168349..168681)
/note="Ty2 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007102"
gene 168795..168883
/gene="SUP5"
/locus_tag="YNCM0006W"
/db_xref="GeneID:854951"
tRNA join(168795..168833,168848..168883)
/gene="SUP5"
/locus_tag="YNCM0006W"
/product="tRNA-Tyr"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE
analysis; can mutate to suppress ochre nonsense mutations"
/db_xref="GeneID:854951"
/db_xref="SGD:S000006783"
gene complement(<169116..>169754)
/locus_tag="YML053C"
/db_xref="GeneID:854952"
mRNA complement(<169116..>169754)
/locus_tag="YML053C"
/product="uncharacterized protein"
/transcript_id="NM_001182411.1"
/db_xref="GeneID:854952"
CDS complement(169116..169754)
/locus_tag="YML053C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="hypothetical protein; green fluorescent protein
(GFP)-fusion protein localizes to the cytoplasm and the
nucleus; overexpression causes a cell cycle delay or
arrest; YML053C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013659.1"
/db_xref="GeneID:854952"
/db_xref="SGD:S000004517"
/translation="MLSYYEHNTAFQTNNCNSGSNAATTYNSDANNDTIMNKRKNDHF
EFDTHTFYQRSKRTKRDSVSTKFSVGSGCANLNNNNNNIIINNNNNNNNNNNNHNHNN
SNNTATYNNIHYKKNIEICPLKPVSMHHTMNSRLLNESEFYSETEEYMIHGYFGNTNR
DITGTSPTGSASIIQHQYHLLPSQSIIASQAPGTAMAALTNNNIANDYMDID"
gene <170402..>171310
/gene="SUR7"
/locus_tag="YML052W"
/db_xref="GeneID:854953"
mRNA <170402..>171310
/gene="SUR7"
/locus_tag="YML052W"
/product="Sur7p"
/transcript_id="NM_001182410.1"
/db_xref="GeneID:854953"
CDS 170402..171310
/gene="SUR7"
/locus_tag="YML052W"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:12469340|PMID:17507646]"
/experiment="EXISTENCE:direct assay:GO:0005938 cell cortex
[PMID:11784867|PMID:16496001]"
/experiment="EXISTENCE:direct assay:GO:0032126 eisosome
[PMID:16496001|PMID:15536122]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0006897
endocytosis [PMID:16496001]"
/experiment="EXISTENCE:mutant phenotype:GO:0030437
ascospore formation [PMID:11784867]"
/experiment="EXISTENCE:mutant phenotype:GO:0097446 protein
localization to eisosome filament [PMID:25811606]"
/note="Plasma membrane protein, component of eisosomes;
long-lived protein that remains stable in eisosomes of
mother cells while other eisosome proteins, Pil1p and
Lsp1p, turn over; may function to anchor the eisosome in
place; sporulation and plasma membrane sphingolipid
content are altered in mutants; localizes to furrow-like
invaginations (MCC patches)"
/codon_start=1
/product="Sur7p"
/protein_id="NP_013660.1"
/db_xref="GeneID:854953"
/db_xref="SGD:S000004516"
/translation="MVKVWNIVLRLVVLLFLAGNTLLLILMIISGATDHYPVNRFYWV
QGNTTGIPNAGDETRWTFWGACLQDKDGSDTCTSNLAPAYPISPVDNFNTHINVPHQF
ISKRDAFYYLTRFSFCFFWIALAFVGVSFILYVLTWCSKMLSEMVLILMSFGFVFNTA
AVVLQTAASAMAKNAFHDDHRSAQLGASMMGMAWASVFLCIVEFILLVFWSVRARLAS
TYSIDNSRYRTSSRWNPFHREKEQATDPILTATGPEDMQQSASIVGPSSNANPVTATA
ATENQPKGINFFTIRKSHERPDDVSV"
gene <171594..>172901
/gene="GAL80"
/locus_tag="YML051W"
/db_xref="GeneID:854954"
mRNA <171594..>172901
/gene="GAL80"
/locus_tag="YML051W"
/product="transcription regulator GAL80"
/transcript_id="NM_001182409.1"
/db_xref="GeneID:854954"
CDS 171594..172901
/gene="GAL80"
/locus_tag="YML051W"
/experiment="EXISTENCE:direct assay:GO:0000122 negative
regulation of transcription by RNA polymerase II
[PMID:9811836]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10866670|PMID:18952899]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10866670|PMID:18952899]"
/experiment="EXISTENCE:direct assay:GO:0019210 kinase
inhibitor activity [PMID:18957435]"
/experiment="EXISTENCE:direct assay:GO:0042326 negative
regulation of phosphorylation [PMID:18957435]"
/experiment="EXISTENCE:direct assay:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:9811836]"
/experiment="EXISTENCE:mutant phenotype:GO:0000122
negative regulation of transcription by RNA polymerase II
[PMID:6092916]"
/experiment="EXISTENCE:mutant phenotype:GO:0006012
galactose metabolic process [PMID:6092916]"
/experiment="EXISTENCE:physical interaction:GO:0000122
negative regulation of transcription by RNA polymerase II
[PMID:9811836]"
/experiment="EXISTENCE:physical interaction:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:9811836]"
/note="Transcriptional regulator involved in the
repression of GAL genes; involved in the repression of GAL
genes in the absence of galactose; inhibits
transcriptional activation by Gal4p; inhibition relieved
by Gal3p or Gal1p binding"
/codon_start=1
/product="transcription regulator GAL80"
/protein_id="NP_013661.1"
/db_xref="GeneID:854954"
/db_xref="SGD:S000004515"
/translation="MDYNKRSSVSTVPNAAPIRVGFVGLNAAKGWAIKTHYPAILQLS
SQFQITALYSPKIETSIATIQRLKLSNATAFPTLESFASSSTIDMIVIAIQVASHYEV
VMPLLEFSKNNPNLKYLFVEWALACSLDQAESIYKAAAERGVQTIISLQGRKSPYILR
AKELISQGYIGDINSIEIAGNGGWYGYERPVKSPKYIYEIGNGVDLVTTTFGHTIDIL
QYMTSSYFSRINAMVFNNIPEQELIDERGNRLGQRVPKTVPDHLLFQGTLLNGNVPVS
CSFKGGKPTKKFTKNLVIDIHGTKGDLKLEGDAGFAEISNLVLYYSGTRANDFPLANG
QQAPLDPGYDAGKEIMEVYHLRNYNAIVGNIHRLYQSISDFHFNTKKIPELPSQFVMQ
GFDFEGFPTLMDALILHRLIESVYKSNMMGSTLNVSNISHYSL"
gene <173139..>174074
/gene="AIM32"
/locus_tag="YML050W"
/db_xref="GeneID:854955"
mRNA <173139..>174074
/gene="AIM32"
/locus_tag="YML050W"
/product="Aim32p"
/transcript_id="NM_001182408.1"
/db_xref="GeneID:854955"
CDS 173139..174074
/gene="AIM32"
/locus_tag="YML050W"
/experiment="EXISTENCE:direct assay:GO:0005758
mitochondrial intermembrane space [PMID:34461091]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:30879301|PMID:34461091]"
/experiment="EXISTENCE:mutant phenotype:GO:0045454 cell
redox homeostasis [PMID:34461091]"
/experiment="EXISTENCE:mutant phenotype:GO:0065003
protein-containing complex assembly [PMID:34461091]"
/note="2Fe-2S mitochondrial protein involved in redox
quality control; may maintain protein redox status by
targeting oxidation sensitive cysteine residues;
bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster
containing thiredoxin-like ferredoxin; forms a functional
complex with Osm1p and Erv1p in the IMS; required for
assembly of numerous mitochondrial import complexes;
essential for anaerobiosis; localizes to the mitochondrial
matrix and intermembrane space (IMS); homologous to APD1"
/codon_start=1
/product="Aim32p"
/protein_id="NP_013662.1"
/db_xref="GeneID:854955"
/db_xref="SGD:S000004514"
/translation="MLRITVKTLQQRASFHHSFKHISVPDLHTRAQNDQTNCYCQEIN
ARLPSKTDPLDPHIKLPHRTPNYNKHVLLLSPGDRFAQPWKVAWNHNLDTNTNRPYNA
ISKLRSHLGGSPGILINAVHLQNEFIPRPKQHDEWLYFFVIPDMKLYVIKETDIEEFA
SFLDEGAIQAPKLSFQDYLSGKAKASQQVHEVHHRKLTRFQGETFLRDWNLVCGHYKR
DAKCGEMGPDIIAAFQDEKLFPENNLALISHIGGHIFAGNVIFYKLFGREKMQNKLDS
LWFGKVYPHNLKLLCENLENGKIIDEMYRGGISMN"
gene complement(<174220..>178305)
/gene="RSE1"
/locus_tag="YML049C"
/db_xref="GeneID:854956"
mRNA complement(<174220..>178305)
/gene="RSE1"
/locus_tag="YML049C"
/product="U2 snRNP complex subunit RSE1"
/transcript_id="NM_001182407.1"
/db_xref="GeneID:854956"
CDS complement(174220..178305)
/gene="RSE1"
/locus_tag="YML049C"
/experiment="EXISTENCE:direct assay:GO:0000245
spliceosomal complex assembly [PMID:10369685]"
/experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP
[PMID:15565172|PMID:16314500]"
/experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA
binding [PMID:10369685]"
/experiment="EXISTENCE:direct assay:GO:0071004 U2-type
prespliceosome [PMID:16618970]"
/experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA
splicing, via spliceosome [PMID:9819400]"
/experiment="EXISTENCE:physical interaction:GO:0000398
mRNA splicing, via spliceosome [PMID:16314500]"
/note="Protein involved in pre-mRNA splicing; component of
the pre-spliceosome; associates with U2 snRNA; involved in
ER to Golgi transport"
/codon_start=1
/product="U2 snRNP complex subunit RSE1"
/protein_id="NP_013663.1"
/db_xref="GeneID:854956"
/db_xref="SGD:S000004513"
/translation="MWGGGKMAVVSLSPHTAKMRKLFGQASTTMAYDGLKREAERRTR
SDHNITMVAKDDELYLYHLTLKKQTNFVHSCIGHFVDLEAGSKREQSQLCVATETHLE
LYDTADGELKLIAKFQNLFATITSMKSLDLPHSGSRAKASNWPTFLALTSDSGNLSIV
QIIMHAGALRLKTLVNQPLTRTTLRRVSPISYMEIDPNGRCIILSSVEQNKLCFLVDY
AQKLRISSPLEIIRPHMVTLDMAVVDVNFNNPCFVTLEIDNAATQLSVHLIFYVLELG
LNHIVKKADYLVNPSANFVLSLPDLSRYNITTSLSDNNYDADYDTLFNPFVVIGFENH
ILVKDMNGFFSLKVEIPKRSITNSRHKNVTIISGIVQKLKNDFFVLLQSNHGDLFKLT
VSPDTNDRNRPLVQLSYFDTIQNSHQLHIFKNGYLFALSEMNNNFLFQFEKLGVEKND
FSNVLTSKDPNKSLVFEPSIKLQNLSILSQQLNLNPSIKSQIVSDSPLSIATKHFTNN
KIITLTNAVNYSNLISTSLPPNATKLWLIPDPATTGDNNTLLFITFPKKTMILQIDNE
SMEELTPDEATRSAFKLSQDTTIHTCLMGSHSIIQVCTAELRHIVPTGKSRYSNKLTW
VPPAGIRIVCATSSKTQLIISLSNYELVYFKIDVSSDSLIELTTHPELDTMPSKVAIV
QDTQHADLLAIADNEGMIKIMSLKDQKEDFLTVISLQLVSEKISDMIMVRDSSIGQLN
LHVGLENGVYMKFHIGDVDGSFTDIKRRFLGLKPVSLSYLREISVSLNNEEEEEEEED
DDDEKEEEEINSSGAKWMSCVVCHSSSTWVSYTWKNVWTIRQLKDQNMLSCSKFVNAD
VAINGVCSISSSGRLNIGRVSNFPTLDNWFHVHESSVNKQENGGGDESNEEEEDEMEE
EMEMLQISTFRPRTILSFPNNPKSILFIDNHSGKKQCRISLQIDGECLKFGSSDHLYK
ILDDIDCVSAAIIDFTRQADHLIICAGDKRLLTYKILVNKDKLSFDIELLHQTEIISP
IHAMLKFKNFLLTAMGSTIVLYGLGKKQLLRRSVTQTPVSITKIVSMHQWNYERLAVG
DIHESVTLFIWDPAGNVFIPYVDDSVKRHVTVLKFLDEATVIGADRYGNAWTLRSPPE
CEKIMSNHDPSELSNGAIKYPLDVITLQQKLPNTYDCKFKFQLLNHFFVNDIITDFHI
LDSLSNSDRPGCIYMGLQGTVGCFIPLLSKGNVFMMGNIENIMAEADDTFYLDYESRK
KNNNMRKEDDEEESGSVVLQGRHGIEDEIICEGSCSILGRDHQEYRSYYAPVRKVIDG
DLCENFLRLSLNEQEFLAKNLKSVQVEDIIQTINEVRTNYM"
gene <178426..>179637
/gene="GSF2"
/locus_tag="YML048W"
/gene_synonym="ECM6"
/db_xref="GeneID:854957"
mRNA <178426..>179637
/gene="GSF2"
/locus_tag="YML048W"
/gene_synonym="ECM6"
/product="Gsf2p"
/transcript_id="NM_001182405.1"
/db_xref="GeneID:854957"
CDS 178426..179637
/gene="GSF2"
/locus_tag="YML048W"
/gene_synonym="ECM6"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:10377429]"
/experiment="EXISTENCE:genetic interaction:GO:0034394
protein localization to cell surface [PMID:10377429]"
/experiment="EXISTENCE:mutant phenotype:GO:0006457 protein
folding [PMID:15623581]"
/experiment="EXISTENCE:mutant phenotype:GO:0034394 protein
localization to cell surface [PMID:10377429]"
/experiment="EXISTENCE:mutant phenotype:GO:0051082
unfolded protein binding [PMID:15623581]"
/note="Endoplasmic reticulum (ER) localized integral
membrane protein; may promote secretion of certain hexose
transporters, including Gal2p; involved in
glucose-dependent repression"
/codon_start=1
/product="Gsf2p"
/protein_id="NP_013664.1"
/db_xref="GeneID:854957"
/db_xref="SGD:S000004511"
/translation="MEIYIRLNADVEHDYAFQVSNEDTINNKIKKIFPSKTGLADLMV
LRPSIFHEKEPVKFYKSIHPGYLSEGGCLMFHYEADNEENLEELNDSKPLIDQLWPGQ
LVVPEWKLSKKNIWVYTIIMLAWLYTDLPDAISPTPGICLTNQLSRLLIPVAKHMDLP
EIAAKLEQEVQANYSSLVAQWLFFVMHIFKVGIITLFLKLGIANPISFNPYKLWSLRD
LTSPSANGAKNSGGNNNTTDLKTRLRSLGWIGAKRATYDDYQTNYYNYVIDKMGGAVA
AYRAGAIRKAAAPGIQLVAGEGFQSPLEDRFTASTFTAIKTERKFILSEEYFVELENN
LKKILEEYDGDIGKMNAEIRRFRRFGIYEPDEKLASLVKLRREIADEKEKASNNDATF
GIKKNDLKKSN"
gene complement(<180017..>181075)
/gene="PRM6"
/locus_tag="YML047C"
/gene_synonym="KCH2"
/db_xref="GeneID:854959"
mRNA complement(<180017..>181075)
/gene="PRM6"
/locus_tag="YML047C"
/gene_synonym="KCH2"
/product="pheromone-regulated K(+) transporter PRM6"
/transcript_id="NM_001182404.1"
/db_xref="GeneID:854959"
CDS complement(180017..181075)
/gene="PRM6"
/locus_tag="YML047C"
/gene_synonym="KCH2"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:23204190]"
/experiment="EXISTENCE:direct assay:GO:0005934 cellular
bud tip [PMID:23204190]"
/experiment="EXISTENCE:direct assay:GO:0043332 mating
projection tip [PMID:23204190]"
/experiment="EXISTENCE:genetic interaction:GO:0015079
potassium ion transmembrane transporter activity
[PMID:23204190]"
/experiment="EXISTENCE:genetic interaction:GO:0071805
potassium ion transmembrane transport [PMID:23204190]"
/note="Potassium transporter that mediates K+ influx;
activates high-affinity Ca2+ influx system (HACS) during
mating pheromone response; expression up-regulated in
response to alpha factor; regulated by Ste12p during
mating; localized to sites of polarized growth; member of
a fungal-specific gene family; PRM6 has a paralog, KCH1,
that arose from the whole genome duplication"
/codon_start=1
/product="pheromone-regulated K(+) transporter PRM6"
/protein_id="NP_013666.1"
/db_xref="GeneID:854959"
/db_xref="SGD:S000004510"
/translation="MESSLQKLKFQDIDINLIPTAKWTTKLQYILYTWCQSILHVAMF
FSDIYTCIKLLAFNTWSNNIIQPFLEFRISKWLFSGCILCSSLILIWELVIGLRVYRK
KEITSNYMNGISRLINCLFNFKKYQIFELIVLTDEKKFSKWLFFSYFEISGCLRLLFG
DSPRQIINGLTLWSVLLTVSNETSSGTHSTQSLGNLDDLNGIINKIKHIAKTNYEESV
ILSFMLFSFIIWVILISKLILSIIIFIIFIRPRFLSSKRKVKGYELKLRKYVSKVIDE
NLSRTVYELGILIDDEEEGTICGDNKTQKKFDYDSPDYGDESTIPSYYCYSDVETYER
VYTPIKAYFPQKYKHKYI"
gene <181474..>183363
/gene="PRP39"
/locus_tag="YML046W"
/db_xref="GeneID:854960"
mRNA <181474..>183363
/gene="PRP39"
/locus_tag="YML046W"
/product="Prp39p"
/transcript_id="NM_001182403.1"
/db_xref="GeneID:854960"
CDS 181474..183363
/gene="PRP39"
/locus_tag="YML046W"
/experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP
[PMID:8196608|PMID:9630245]"
/experiment="EXISTENCE:direct assay:GO:0071004 U2-type
prespliceosome [PMID:16618970]"
/experiment="EXISTENCE:genetic interaction:GO:0000243
commitment complex [PMID:8196608]"
/experiment="EXISTENCE:genetic interaction:GO:0000395 mRNA
5'-splice site recognition [PMID:8196608]"
/experiment="EXISTENCE:genetic interaction:GO:0030627
pre-mRNA 5'-splice site binding [PMID:8196608]"
/note="U1 snRNP protein involved in splicing; contains
multiple tetriatricopeptide repeats"
/codon_start=1
/product="Prp39p"
/protein_id="NP_013667.1"
/db_xref="GeneID:854960"
/db_xref="SGD:S000004509"
/translation="MPDETNFTIEDIEPRPDALRGLDTQFLQDNTALVQAYRGLDWSD
ISSLTQMVDVIEQTVVKYGNPNDSIKLALETILWQILRKYPLLFGFWKRFATIEYQLF
GLKKSIAVLATSVKWFPTSLELWCDYLNVLCVNNPNETDFIRNNFEIAKDLIGKQFLS
HPFWDKFIEFEVGQKNWHNVQRIYEYIIEVPLHQYARFFTSYKKFLNEKNLKTTRNID
IVLRKTQTTVNEIWQFESKIKQPFFNLGQVLNDDLENWSRYLKFVTDPSKSLDKEFVM
SVFDRCLIPCLYHENTWMMYIKWLTKKNISDEVVVDIYQKANTFLPLDFKTLRYDFLR
FLKRKYRSNNTLFNNIFNETVSRYLKIWPNDILLMTEYLCMLKRHSFKNSLDQSPKEI
LEKQTSFTKILETSITNYINNQIDAKVHLQTLINDKNLSIVVVELIKTTWLVLKNNMQ
TRKYFNLYQKNILIKNSVPFWLTYYKFEKSNVNFTKLNKFIRELGVEIYLPTTVMNDI
LTDYKTFYLTHSNIVTYESSIIDSNTFDPILYPELKMSNPKYDPVLNTTANVDWHKKT
EWKEAGHIGITTERPQISNSIIECNSGTLIQKPISLPNFRNLEKINQVKINDLYTEEF
LKEGK"
rep_origin 183797..183887
/note="ARS1308; Autonomously Replicating Sequence"
/db_xref="SGD:S000118368"
gene complement(183898..183968)
/locus_tag="YNCM0007C"
/db_xref="GeneID:854961"
tRNA complement(183898..183968)
/locus_tag="YNCM0007C"
/product="tRNA-Gly"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0030371 translation
repressor activity [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043555 regulation
of translation in response to stress [PMID:27609601]"
/note="Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:854961"
/db_xref="SGD:S000006585"
mobile_element 184170..190083
/note="YMLWTy1-1; Ty1 element, LTR retrotransposon of the
Copia (Pseudoviridae) group; contains co-transcribed genes
TYA Gag and TYB Pol, encoding proteins involved in
structure and function of virus-like particles, flanked by
two direct repeats"
/mobile_element_type="retrotransposon:YMLWTy1-1"
/db_xref="SGD:S000007107"
repeat_region 184170..184501
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007103"
gene <184461..>189729
/locus_tag="YML045W"
/db_xref="GeneID:854963"
mRNA <184461..>189729
/locus_tag="YML045W"
/product="gag-pol fusion protein"
/transcript_id="NM_001182402.2"
/db_xref="GeneID:854963"
CDS join(184461..185765,185767..189729)
/locus_tag="YML045W"
/EC_number="2.7.7.7"
/EC_number="2.7.7.49"
/EC_number="3.1.26.4"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9448009]"
/ribosomal_slippage
/note="Retrotransposon TYA Gag and TYB Pol genes;
transcribed/translated as one unit; polyprotein is
processed to make a nucleocapsid-like protein (Gag),
reverse transcriptase (RT), protease (PR), and integrase
(IN); similar to retroviral genes"
/codon_start=1
/product="gag-pol fusion protein"
/protein_id="NP_013668.1"
/db_xref="GeneID:854963"
/db_xref="SGD:S000004508"
/translation="MESQQLSNYPNISHGSACASVTSKEVHTNQDPLDVSASKIQEYD
KASTKANSQQTTTPASSAVPENLHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS
FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS
DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT
FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ
YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM
TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN
SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHS
DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD
NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV
SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE
SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS
APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE
YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS
AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI
PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT
ASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE
DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP
MSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKR
IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPD
PFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL
EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL
KMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQS
NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK
KSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDL
NANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP
KLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRF
DLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISD
ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSH
LVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCY
IETKKNIADVMTKPLPIKTFKLLTNKWIH"
gene <184461..>185783
/locus_tag="YML045W-A"
/db_xref="GeneID:854962"
mRNA <184461..>185783
/locus_tag="YML045W-A"
/product="gag protein"
/transcript_id="NM_001184412.1"
/db_xref="GeneID:854962"
CDS 184461..185783
/locus_tag="YML045W-A"
/note="Retrotransposon TYA Gag gene co-transcribed with
TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is
a nucleocapsid protein that is the structural constituent
of virus-like particles (VLPs); similar to retroviral Gag"
/codon_start=1
/product="gag protein"
/protein_id="NP_058176.1"
/db_xref="GeneID:854962"
/db_xref="SGD:S000007381"
/translation="MESQQLSNYPNISHGSACASVTSKEVHTNQDPLDVSASKIQEYD
KASTKANSQQTTTPASSAVPENLHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS
FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS
DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT
FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ
YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM
TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN
SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY"
repeat_region 189752..190083
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007104"
gene complement(<190244..>191767)
/gene="RRN11"
/locus_tag="YML043C"
/db_xref="GeneID:854964"
mRNA complement(<190244..>191767)
/gene="RRN11"
/locus_tag="YML043C"
/product="Rrn11p"
/transcript_id="NM_001182401.1"
/db_xref="GeneID:854964"
CDS complement(190244..191767)
/gene="RRN11"
/locus_tag="YML043C"
/experiment="EXISTENCE:direct assay:GO:0001164 RNA
polymerase I core promoter sequence-specific DNA binding
[PMID:18451108]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:23613772]"
/experiment="EXISTENCE:direct assay:GO:0017025 TBP-class
protein binding [PMID:8702872]"
/experiment="EXISTENCE:direct assay:GO:0042790 nucleolar
large rRNA transcription by RNA polymerase I
[PMID:8887672]"
/experiment="EXISTENCE:direct assay:GO:0070860 RNA
polymerase I core factor complex
[PMID:8702872|PMID:8887672]"
/experiment="EXISTENCE:genetic interaction:GO:0042790
nucleolar large rRNA transcription by RNA polymerase I
[PMID:8702872]"
/experiment="EXISTENCE:mutant phenotype:GO:0042790
nucleolar large rRNA transcription by RNA polymerase I
[PMID:8702872]"
/experiment="EXISTENCE:physical interaction:GO:0017025
TBP-class protein binding [PMID:8702872]"
/note="Component of the core factor (CF) rDNA
transcription factor complex; CF is required for
transcription of 35S rRNA genes by RNA polymerase I and is
composed of Rrn6p, Rrn7p, and Rrn11p"
/codon_start=1
/product="Rrn11p"
/protein_id="NP_013669.1"
/db_xref="GeneID:854964"
/db_xref="SGD:S000004507"
/translation="MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSTTTDSL
PTPENSAAENNDEEEGQNSEAGTYRRSVLQQKKRRRERHWRSVVGEIYSTTESETDSQ
EEETEEGGEHDTGIDKEDSDEERKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYH
NFKKIEKIPLRKMEIPLLHCTKENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTD
LLHLNVSRHNWSLAYKIFATLIRIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQ
IYSSKSRFVQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSMEPSSNIIDKP
FDTENDLLQELIDKISEWVLTPPFMEDAEVWFIYASCHLLKADTLSRQFVNDNKNNDL
IGLDRDIKINQVIKHIHYVRTFLKICLDKGGFAVPSRLIENQLKSFESRLYGEAQDIQ
ERDVANVYDSIDNSSVENSFGDVYETNAEFLDTQLMDLSPEDNGLDEMHYSDEDSSE"
gene <192788..>194800
/gene="CAT2"
/locus_tag="YML042W"
/gene_synonym="YCAT"
/db_xref="GeneID:854965"
mRNA <192788..>194800
/gene="CAT2"
/locus_tag="YML042W"
/gene_synonym="YCAT"
/product="carnitine O-acetyltransferase CAT2"
/transcript_id="NM_001182400.1"
/db_xref="GeneID:854965"
CDS 192788..194800
/gene="CAT2"
/locus_tag="YML042W"
/gene_synonym="YCAT"
/EC_number="2.3.1.7"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14576278|PMID:16823961|PMID:18427809|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
[PMID:18427809|PMID:22375831]"
/experiment="EXISTENCE:mutant phenotype:GO:0004092
carnitine O-acetyltransferase activity [PMID:8420957]"
/experiment="EXISTENCE:mutant phenotype:GO:0009437
carnitine metabolic process [PMID:11329169]"
/note="Carnitine acetyl-CoA transferase; present in both
mitochondria and peroxisomes; transfers activated acetyl
groups to carnitine to form acetylcarnitine which can be
shuttled across membranes"
/codon_start=1
/product="carnitine O-acetyltransferase CAT2"
/protein_id="NP_013670.1"
/db_xref="GeneID:854965"
/db_xref="SGD:S000004506"
/translation="MRICHSRTLSNLKDLPITSRRAMHSAIVNYSTQKAQFPVETNNG
EHYWAEKPNKFYQNKRPNFQGITFAKQQDLPSLPVPELKSTLDKYLQTIRPFCNDVET
FERQQLLCKDFSEHMGPILQDRLKEYANDKRNWMAKFWDEQSYLQYNDPIVPYVSYFY
SHMPLPNHLSKIDNDPLIKATAIISTVVKFIEAIKDESLPVEIIKGMPFCMNSFSLMF
NTSRLPGKPEDNQDTNIFYSVYENNFVTIAYKGKFYKLMTHDGNDKPLSENEIWRQLY
SVVFQGSQSDPKLGGIGSLTSLPRDQWREVHLELMKDPISQDSLETIHKSSFMLCLDL
DQSPVTLEEKSRNCWHGDGINRFYDKSLQFLVTGNGSSGFLAEHSKMDGTPTLFLNNY
VCQQLNKLDVDDFMRKVITPSSTVAMKPMELPFIITPKIHKAIESAQLQFKETIGEHD
LRVWHYNKYGKTFIKRHGMSPDAFIQQVIQLAVFKYLKRQLPTYEAASTRKYFKGRTE
TGRSVSTASLEFVSKWQNGDVPIAEKIQALKHSAKEHSTYLKNAANGNGVDRHFFGLK
NMLKSNDDQIPPLFKDPLFNYSSTWLISTSQLSSEYFDGYGWSQVNDNGFGLAYMLNN
EWLHINIVNKPAKSGASVNRLHYYLSQAADEIFDALENENKRKAKL"
gene complement(<194913..>195755)
/gene="VPS71"
/locus_tag="YML041C"
/gene_synonym="SWC6"
/db_xref="GeneID:854966"
mRNA complement(<194913..>195755)
/gene="VPS71"
/locus_tag="YML041C"
/gene_synonym="SWC6"
/product="Vps71p"
/transcript_id="NM_001182399.1"
/db_xref="GeneID:854966"
CDS complement(194913..195755)
/gene="VPS71"
/locus_tag="YML041C"
/gene_synonym="SWC6"
/experiment="EXISTENCE:direct assay:GO:0000812 Swr1
complex [PMID:14645854|PMID:14690608]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006338 chromatin
remodeling [PMID:14645854]"
/experiment="EXISTENCE:mutant phenotype:GO:0006338
chromatin remodeling [PMID:14690608]"
/experiment="EXISTENCE:mutant phenotype:GO:0006623 protein
targeting to vacuole [PMID:12134085]"
/experiment="EXISTENCE:mutant phenotype:GO:0031491
nucleosome binding [PMID:16299513]"
/note="Nucleosome-binding component of the SWR1 complex;
SWR1 exchanges histone variant H2AZ (Htz1p) for
chromatin-bound histone H2A; required for vacuolar protein
sorting"
/codon_start=1
/product="Vps71p"
/protein_id="NP_013671.1"
/db_xref="GeneID:854966"
/db_xref="SGD:S000004505"
/translation="MKALVEEIDKKTYNPDIYFTSLDPQARRYTSKKINKQGTISTSR
PVKRINYSLADLEARLYTSRSEGDGNSISRQDDRNSKNSHSFEERYTQQEILQSDRRF
MELNTENFSDLPNVPTLLSDLTGVPRDRIESTTKPISQTSDGLSALMGGSSFVKEHSK
YGHGWVLKPETLREIQLSYKSTKLPKPKRKNTNRIVALKKVLSSKRNLHSFLDSALLN
LMDKNVIYHNVYNKRYFKVLPLITTCSICGGYDSISSCVNCGNKICSVSCFKLHNETR
CRNR"
gene complement(196068..196170)
/gene="SUF7"
/locus_tag="YNCM0008C"
/db_xref="GeneID:854967"
tRNA complement(join(196068..196103,196135..196170))
/gene="SUF7"
/locus_tag="YNCM0008C"
/product="tRNA-Pro"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE
analysis; target of K. lactis zymocin; can mutate to
suppress +1 frameshift mutations in proline codons"
/db_xref="GeneID:854967"
/db_xref="SGD:S000006684"
mobile_element 196332..202234
/note="YMLWTy1-2; Ty1 element, LTR retrotransposon of the
Copia (Pseudoviridae) group; contains co-transcribed genes
TYA Gag and TYB Pol, encoding proteins involved in
structure and function of virus-like particles, flanked by
two direct repeats"
/mobile_element_type="retrotransposon:YMLWTy1-2"
/db_xref="SGD:S000007108"
repeat_region 196332..196668
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007105"
gene <196628..>201896
/locus_tag="YML039W"
/db_xref="GeneID:854969"
mRNA <196628..>201896
/locus_tag="YML039W"
/product="gag-pol fusion protein"
/transcript_id="NM_001182397.2"
/db_xref="GeneID:854969"
CDS join(196628..197932,197934..201896)
/locus_tag="YML039W"
/EC_number="2.7.7.7"
/EC_number="2.7.7.49"
/EC_number="3.1.26.4"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9448009]"
/ribosomal_slippage
/note="Retrotransposon TYA Gag and TYB Pol genes;
transcribed/translated as one unit; polyprotein is
processed to make a nucleocapsid-like protein (Gag),
reverse transcriptase (RT), protease (PR), and integrase
(IN); similar to retroviral genes"
/codon_start=1
/product="gag-pol fusion protein"
/protein_id="NP_013672.1"
/db_xref="GeneID:854969"
/db_xref="SGD:S000004503"
/translation="MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECE
KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS
FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS
DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT
FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ
YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM
TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN
SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHS
DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD
NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV
SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE
SDVDRSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS
APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE
YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS
AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI
PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT
ASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE
DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP
MSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKR
IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPD
PFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL
EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL
KMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQS
NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK
KSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDL
NANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP
KLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRF
DLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISD
ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSY
LIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYY
IETKKNIADVMTKPLPIKTFKLLTNKWIH"
gene <196628..>197950
/locus_tag="YML040W"
/db_xref="GeneID:854968"
mRNA <196628..>197950
/locus_tag="YML040W"
/product="gag protein"
/transcript_id="NM_001182398.1"
/db_xref="GeneID:854968"
CDS 196628..197950
/locus_tag="YML040W"
/note="Retrotransposon TYA Gag gene co-transcribed with
TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is
a nucleocapsid protein that is the structural constituent
of virus-like particles (VLPs); similar to retroviral Gag"
/codon_start=1
/product="gag protein"
/protein_id="NP_013673.1"
/db_xref="GeneID:854968"
/db_xref="SGD:S000004504"
/translation="MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECE
KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS
FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS
DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT
FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ
YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM
TVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNN
SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY"
repeat_region 201919..202234
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007106"
gene complement(<202775..>204103)
/gene="YMD8"
/locus_tag="YML038C"
/db_xref="GeneID:854970"
mRNA complement(<202775..>204103)
/gene="YMD8"
/locus_tag="YML038C"
/product="Ymd8p"
/transcript_id="NM_001182396.1"
/db_xref="GeneID:854970"
CDS complement(202775..204103)
/gene="YMD8"
/locus_tag="YML038C"
/experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated
vesicle [PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0015786
UDP-glucose transmembrane transport [PMID:18693752]"
/note="Putative nucleotide sugar transporter; has
similarity to Vrg4p"
/codon_start=1
/product="Ymd8p"
/protein_id="NP_013674.1"
/db_xref="GeneID:854970"
/db_xref="SGD:S000004502"
/translation="MNRTVFLAFVFGWYFCSIALSIYNRWMFDPKDGLGIGYPVLVTT
FHQATLWLLSGIYIKLRHKPVKNVLRKNNGFNWSFFLKFLLPTAVASAGDIGLSNVSF
QYVPLTIYTIIKSSSIAFVLLFGCIFKLEKFHWKLALSVIIMFVGVALMVFKPSDSTS
TKNDQALVIFGSFLVLASSCLSGLRWVYTQLMLRNNPIQTNTAAAVEESDGALFTENE
DNVDNEPVVNLANNKMLENFGESKPHPIHTIHQLAPIMGITLLLTSLLVEKPFPGIFS
SSIFRLDTSNGGVGTETTVLSIVRGIVLLILPGFAVFLLTICEFSILEQTPVLTVSIV
GIVKELLTVIFGIIILSERLSGFYNWLGMLIIMADVCYYNYFRYKQDLLQKYHSVSTQ
DNRNELKGFQDFEQLGSKKIAPYSISVDLTNQEYELDMIAQNVSRSSQQV"
gene complement(<204386..>205408)
/locus_tag="YML037C"
/db_xref="GeneID:854971"
mRNA complement(<204386..>205408)
/locus_tag="YML037C"
/product="uncharacterized protein"
/transcript_id="NM_001182395.1"
/db_xref="GeneID:854971"
CDS complement(204386..205408)
/locus_tag="YML037C"
/experiment="EXISTENCE:direct assay:GO:0030136
clathrin-coated vesicle [PMID:14562095]"
/note="hypothetical protein; has some characteristics of a
transcriptional activator; may be a target of Dbf2p-Mob1p
kinase; GFP-fusion protein co-localizes with
clathrin-coated vesicles; YML037C is not an essential
gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013675.1"
/db_xref="GeneID:854971"
/db_xref="SGD:S000004501"
/translation="MDENKIIDQLFSKEYTPQDDSEQAKNGDVSLYGLLDEVANGRRL
MNCLFHSPMQMGNKLSTDKLDGKCRQIQRDWIDEEKTITMNSGALQLDGPVLFSWSHN
VAPTSHQETINTTFKQGSPSRGSNKPKITTTSQLFDRASAEIDKCIKPNSKSWMVEER
FERNEAHTADGKKPSTWANSDFKVDPLQKFVVKELPKEKKKSDGDKTKKNKSKRKSFF
GFWGHSGSKSGSKKKSEKPIEAKNEIQDEVSQKSGLSPDDDTTFSDKNTIQSKQESMS
DQQAEPKVHEPAVTNTGCSEHDDGDGFEQVPAQSSYHPSSEPSIASTPSLTLDSFIPL
QPKKKI"
gene <205642..>206293
/gene="CGI121"
/locus_tag="YML036W"
/db_xref="GeneID:854972"
mRNA join(<205642..206097,206204..>206293)
/gene="CGI121"
/locus_tag="YML036W"
/product="Cgi121p"
/transcript_id="NM_001182394.1"
/db_xref="GeneID:854972"
CDS join(205642..206097,206204..206293)
/gene="CGI121"
/locus_tag="YML036W"
/experiment="EXISTENCE:direct assay:GO:0000049 tRNA
binding [PMID:33277478]"
/experiment="EXISTENCE:direct assay:GO:0000408 EKC/KEOPS
complex [PMID:16564010|PMID:16874308]"
/experiment="EXISTENCE:genetic interaction:GO:0000722
telomere maintenance via recombination [PMID:23390378]"
/experiment="EXISTENCE:genetic interaction:GO:0000723
telomere maintenance [PMID:16564010]"
/experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA
binding [PMID:33277478]"
/experiment="EXISTENCE:mutant phenotype:GO:0000722
telomere maintenance via recombination [PMID:25822194]"
/experiment="EXISTENCE:mutant phenotype:GO:0000723
telomere maintenance [PMID:16564010]"
/experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA
recombination [PMID:23390378]"
/experiment="EXISTENCE:physical interaction:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:16874308]"
/note="Component of the EKC/KEOPS complex; EKC/KEOPS
complex is required for t6A tRNA modification and
telomeric TG1-3 recombination; may have role in
transcription; Cgi121p is dispensable for tRNA
modification; other complex members are Bud32p, Kae1p,
Pcc1p, and Gon7p; ortholog of human TPRKB"
/codon_start=1
/product="Cgi121p"
/protein_id="NP_013676.2"
/db_xref="GeneID:854972"
/db_xref="SGD:S000004500"
/translation="MVVSIIPQFPDIKVSLALFEQVKNAKEIRSKMSELSTSFAFIDP
RLVCSGEQMYSAIYKTLIEVKYNKMRTRNLNSECVLCLSPTSNISDAFLKFGIKDDSS
QLICLKFHTNTDDVDKEQLRTIMTSIVKGQEIEFNDDNLSRFYDEALIRKIYKLSDDF
KPQDVNGLSRALVDAIQLRGV"
gene complement(<206428..>208860)
/gene="AMD1"
/locus_tag="YML035C"
/gene_synonym="AMD3"
/db_xref="GeneID:854973"
mRNA complement(<206428..>208860)
/gene="AMD1"
/locus_tag="YML035C"
/gene_synonym="AMD3"
/product="AMP deaminase"
/transcript_id="NM_001182392.1"
/db_xref="GeneID:854973"
CDS complement(206428..208860)
/gene="AMD1"
/locus_tag="YML035C"
/gene_synonym="AMD3"
/EC_number="3.5.4.6"
/experiment="EXISTENCE:direct assay:GO:0003876 AMP
deaminase activity [PMID:2690949]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0006163
purine nucleotide metabolic process
[PMID:15869715|PMID:18433446|PMID:19635936]"
/experiment="EXISTENCE:genetic interaction:GO:0006178
guanine salvage [PMID:19635936]"
/experiment="EXISTENCE:mutant phenotype:GO:0003876 AMP
deaminase activity [PMID:2690949]"
/experiment="EXISTENCE:mutant phenotype:GO:0006163 purine
nucleotide metabolic process
[PMID:19635936|PMID:20087341]"
/experiment="EXISTENCE:mutant phenotype:GO:0006178 guanine
salvage [PMID:19635936]"
/note="AMP deaminase; tetrameric enzyme that catalyzes the
deamination of AMP to form IMP and ammonia; thought to be
involved in regulation of intracellular purine (adenine,
guanine, and inosine) nucleotide pools"
/codon_start=1
/product="AMP deaminase"
/protein_id="NP_013677.1"
/db_xref="GeneID:854973"
/db_xref="SGD:S000004498"
/translation="MDNQATQRLNDLSLEPAPSHDEQDGSGLVIDIDQRKIGDEQAGV
VVDDETPPLEQQDSHESLAADSRNANFSYHENQQLLENGTKQLALDEHDSHSAILEQP
SHSTNCSSSNIAAMNKGHDSADHASQNSGGKPRTLSASAQHILPETLKSFAGAPVVNK
QVRTSASYKMGMLADDASQQFLDDPSSELIDLYSKVAECRNLRAKYQTISVQNDDQNP
KNKPGWVVYPPPPKPSYNSDTKTVVPVTNKPDAEVFDFTKCEIPGEDPDWEFTLNDDD
SYVVHRSGKTDELIAQIPTLRDYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYY
LLNEYQETSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIF
RDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIF
LKTNNYIKGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVI
SHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQSHPKLHVFLQRVI
GFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNT
LVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNA
LFLTYDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCEL
ARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDTLSTELELVN
HFANFKRTIEEK"
gene <209525..>212155
/gene="SRC1"
/locus_tag="YML034W"
/gene_synonym="HEH1; YML033W"
/db_xref="GeneID:854974"
mRNA join(<209525..211444,211571..>212155)
/gene="SRC1"
/locus_tag="YML034W"
/gene_synonym="HEH1; YML033W"
/product="Src1p"
/transcript_id="NM_001182391.1"
/db_xref="GeneID:854974"
CDS join(209525..211444,211571..212155)
/gene="SRC1"
/locus_tag="YML034W"
/gene_synonym="HEH1; YML033W"
/experiment="EXISTENCE:direct assay:GO:0000781 chromosome,
telomeric region [PMID:18762579]"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:16929305]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0000070
mitotic sister chromatid segregation [PMID:11754482]"
/experiment="EXISTENCE:genetic interaction:GO:0034087
establishment of mitotic sister chromatid cohesion
[PMID:11754482]"
/experiment="EXISTENCE:mutant phenotype:GO:0043007
maintenance of rDNA [PMID:18997772]"
/note="Chromosome linkage inner nuclear membrane protein;
CLIP, involved in perinuclear chromosome tethering and
rDNA repeat stability; enriched at telomeres and
subtelomeric regions; associates with and regulates
subtelomeric genes, interacting with TREX (transcription
export) factors; produces two splice variants with
different functions; alternative splicing of SRC1 pre-mRNA
is promoted by Hub1p; mutant is aneuploidy tolerant; SRC1
has a paralog, HEH2, that arose from the whole genome
duplication"
/codon_start=1
/product="Src1p"
/protein_id="NP_013679.1"
/db_xref="GeneID:854974"
/db_xref="SGD:S000004497"
/translation="MNSDLEYLEDGFDPNSMKVATLRRILVENNVDFPSNARKNALVG
LFDEKVKPQIPQLRKMYLNVRPSDEGIVKMDRPSSSPSIASPRRSRRARREKSASPMA
KQFKKNRILDDVSNDDDDDDDDDDDNDKKDDPLIVPSGTDTDEVDDEEDDVITSSSNK
SDTNDFQQNSDTRKKRKDPDSDDWSESNSKENKIDNKHLNLLSSDSEIEQDYQKAKKR
KTSDLNQEHGNGSAILGKLSVKTPIKNTNRKPVSMDNFNDSLTSSGTENDPFVPNIRH
NPKELGTANGTGHSTPLSKLKVSASFADKLPQKEVPSTILVPEVEQQEPSQSERTPSL
FSSEGSGSESEAPLLPEITTPGPHQPMGNTSNNVVEMIDTDSSNLVSDEDEVLVPTRI
ETPQLPTEKDVEKCEARVQELQEEVNEQLEHENGSEFDVKQGSGKVGNRHKFKRALKF
LSKSLLALFLFCIFIVIPLLFGLWYREQRLLIGYCGHEVPSHRVSGNSFEFIQKLDNL
LQDYRPKCIPCPPNGICYPYLKLKCKPDYKLAPSRLDFLEIIPAQGKCVKDDKKQQLV
SEVVEKSLEFLRAKNAQISCGDGKDDIESGMTEDALYQIFNEARAPWIRDDEFEDLWI
QVIKDLTEEPEILWRQLSPTDNNIGGNSNNIIKTNDVPRQKRHLPEKFISKTRNFRST
SKKYIGMKCRFEREIYQTYKKFQRPIWLMFLLIVISKVIEIKLKNYYRKKARIEELVT
QTMEKLKFQKIKSMSDPKENAYLSIVQLRDIFLSDIVDLKYKNQLWSEVVKYLEHNNS
NIKSNLTEIRGEIMKCWEWIGPMELNEPKDSAENKI"
gene complement(<212515..>213930)
/gene="RAD52"
/locus_tag="YML032C"
/db_xref="GeneID:854976"
mRNA complement(<212515..>213930)
/gene="RAD52"
/locus_tag="YML032C"
/product="recombinase RAD52"
/transcript_id="NM_001182390.1"
/db_xref="GeneID:854976"
CDS complement(212515..213930)
/gene="RAD52"
/locus_tag="YML032C"
/experiment="EXISTENCE:direct assay:GO:0000150 DNA strand
exchange activity [PMID:15205482]"
/experiment="EXISTENCE:direct assay:GO:0000228 nuclear
chromosome [PMID:12766777]"
/experiment="EXISTENCE:direct assay:GO:0000730 DNA
recombinase assembly [PMID:11459983]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11459964|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:1990814 DNA/DNA
annealing activity [PMID:27362509]"
/experiment="EXISTENCE:genetic interaction:GO:0000709
meiotic joint molecule formation [PMID:18313389]"
/experiment="EXISTENCE:genetic interaction:GO:0045002
double-strand break repair via single-strand annealing
[PMID:11606529]"
/experiment="EXISTENCE:mutant phenotype:GO:0000709 meiotic
joint molecule formation [PMID:18313389]"
/experiment="EXISTENCE:mutant phenotype:GO:0000722
telomere maintenance via recombination
[PMID:11238918|PMID:25822194]"
/experiment="EXISTENCE:mutant phenotype:GO:0000724
double-strand break repair via homologous recombination
[PMID:17096599|PMID:24190138]"
/experiment="EXISTENCE:mutant phenotype:GO:0000727
double-strand break repair via break-induced replication
[PMID:17096599]"
/experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA
amplification [PMID:23271978]"
/experiment="EXISTENCE:mutant phenotype:GO:0006301
postreplication repair [PMID:7038396]"
/experiment="EXISTENCE:mutant phenotype:GO:0043504
mitochondrial DNA repair [PMID:26540255]"
/note="Protein involved in homologous recombination;
attenuates resection of DNA double-strand break ends and
stimulates strand exchange by facilitating Rad51p binding
to single-stranded DNA; anneals complementary
single-stranded DNA; involved in the repair of
double-strand breaks in DNA during vegetative growth and
meiosis and UV induced sister chromatid recombination;
phosphorylation by Cdc28p in G2/M phase promotes Rad52p
ring interaction that leads to superstructure formation"
/codon_start=1
/product="recombinase RAD52"
/protein_id="NP_013680.2"
/db_xref="GeneID:854976"
/db_xref="SGD:S000004494"
/translation="MNEIMDMDEKKPVFGNHSEDIQTKLDKKLGPEYISKRVGFGTSR
IAYIEGWRVINLANQIFGYNGWSTEVKSVVIDFLDERQGKFSIGCTAIVRVTLTSGTY
REDIGYGTVENERRKPAAFERAKKSAVTDALKRSLRGFGNALGNCLYDKDFLAKIDKV
KFDPPDFDENNLFRPTDEISESSRTNTLHENQEQQQYPNKRRQLTKVTNTNPDSTKNL
VKIENTVSRGTPMMAAPAEANSKNSSNKDTDLKSLDASKQDQDDLLDDSLMFSDDFQD
DDLINMGNTNSNVLTTEKDPVVAKQSPTASSNPEAEQITFVTAKAATSVQNERYIGEE
SIFDPKYQAQSIRHTVDQTTSKHIPASVLKDKTMTTARDSVYEKFAPKGKQLSMKNND
KELGPHMLEGAGNQVPRETTPIKTNATAFPPAAAPRFAPPSKVVHPNGNGAVPAVPQQ
RSTRREVGRPKINPLHARKPT"
gene <214189..>216156
/gene="NDC1"
/locus_tag="YML031W"
/db_xref="GeneID:854977"
mRNA <214189..>216156
/gene="NDC1"
/locus_tag="YML031W"
/product="Ndc1p"
/transcript_id="NM_001182389.1"
/db_xref="GeneID:854977"
CDS 214189..216156
/gene="NDC1"
/locus_tag="YML031W"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:20498018]"
/experiment="EXISTENCE:direct assay:GO:0005643 nuclear
pore [PMID:9864355]"
/experiment="EXISTENCE:direct assay:GO:0005816 spindle
pole body [PMID:9864355]"
/experiment="EXISTENCE:direct assay:GO:0070762 nuclear
pore transmembrane ring [PMID:10684247|PMID:19414609]"
/experiment="EXISTENCE:genetic interaction:GO:0006999
nuclear pore organization [PMID:15075274|PMID:16682526]"
/experiment="EXISTENCE:genetic interaction:GO:0017056
structural constituent of nuclear pore [PMID:16682526]"
/experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear
pore organization [PMID:15075274|PMID:16682526]"
/experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle
pole body duplication [PMID:15075274|PMID:8349727]"
/experiment="EXISTENCE:physical interaction:GO:0070762
nuclear pore transmembrane ring [PMID:19414609]"
/note="Subunit of the transmembrane ring of the nuclear
pore complex (NPC); contributes to nucleocytoplasmic
transport, NPC biogenesis and spindle pole body
duplication; homologous to human NDC1"
/codon_start=1
/product="Ndc1p"
/protein_id="NP_013681.1"
/db_xref="GeneID:854977"
/db_xref="SGD:S000004493"
/translation="MIQTPRELLNPRYTYHTIFSDVCKTRFNHLVTRLFFICSIIQTV
VISLLALPHSPLWELALAFIPNILALNLVSLLIIVTRKNYMHVKNFGFANSLTFILGQ
LLSVKFLVYQGVYSMGSILLSFVLGVVFGRGGSGWKPYYKLFIWLVVPTIYNLQHHVT
DADKLSFNCENFFQAPQDYVLERVKRIMEKSVILSVISMFVLPIFTTVFFSRQKSGLF
DSFTNGVLAVTNLLIISCIIFITFEFINIAFDAHMSIGCLHKGKLISNLSSTPMETLL
SGLSADKPFTRLTAYQELAYRATSLDPSLRAPIYHSKFRSSSGNTWSLILNECLKTIQ
INNEKVVQYLRSVQDLGGSATARHKKKVENLDYMYENGKLTSANERLFGNRPSMMAPL
RDNGLLDESPNRLRVRTDDSVLLNRGNKKRHRSSYYDNDLDETTQTFNGSIFTHETTF
MTAMRLMLKKLKNSIMSFIFPSYAERQSSDESDNYRLLPNGSNKAQISIIDIWSISKK
RQAEKLVPLPICHANSVVALTGLLIRSKTEDPKGGIIASVGDILKTLERSICALGEFA
DWDPESMAYTAFQTQRTAQDRVQQDSEDEDSMKDTTDMISVLYQLSTSAFMEIVLEYN
VALNDVYLDADVAKLANWFLEVYASGNPNAT"
gene <216435..>216914
/gene="RCF1"
/locus_tag="YML030W"
/gene_synonym="AIM31"
/db_xref="GeneID:854978"
mRNA <216435..>216914
/gene="RCF1"
/locus_tag="YML030W"
/gene_synonym="AIM31"
/product="Rcf1p"
/transcript_id="NM_001182388.1"
/db_xref="GeneID:854978"
CDS 216435..216914
/gene="RCF1"
/locus_tag="YML030W"
/gene_synonym="AIM31"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14562095|PMID:14576278|PMID:16823961|PMID:24478450|P
MID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane
[PMID:22310663|PMID:22342701|PMID:22405070]"
/experiment="EXISTENCE:direct assay:GO:0005746
mitochondrial respirasome
[PMID:22310663|PMID:22342701|PMID:22405070]"
/experiment="EXISTENCE:genetic interaction:GO:0033617
mitochondrial cytochrome c oxidase assembly
[PMID:22310663]"
/experiment="EXISTENCE:mutant phenotype:GO:0010155
regulation of proton transport [PMID:31591265]"
/experiment="EXISTENCE:mutant phenotype:GO:0033617
mitochondrial cytochrome c oxidase assembly
[PMID:29746825]"
/experiment="EXISTENCE:mutant phenotype:GO:0097250
mitochondrial respirasome assembly
[PMID:22405070|PMID:22342701]"
/note="Cytochrome c oxidase subunit; required for assembly
of the Complex III-Complex IV supercomplex, and for
assembly of Cox13p and Rcf2p into cytochrome c oxidase;
similar to Rcf2p, and either Rcf1p or Rcf2p is required
for late-stage assembly of the Cox12p and Cox13p subunits
and for cytochrome c oxidase activity; required for growth
under hypoxic conditions; member of the hypoxia induced
gene family; C. elegans and human orthologs are functional
in yeast"
/codon_start=1
/product="Rcf1p"
/protein_id="NP_013682.1"
/db_xref="GeneID:854978"
/db_xref="SGD:S000004492"
/translation="MSRMPSSFDVTERDLDDMTFGERIIYHCKKQPLVPIGCLLTTGA
VILAAQNVRLGNKWKAQYYFRWRVGLQAATLVALVAGSFIYGTSGKELKAKEEQLKEK
AKMREKLWIQELERREEETEARRKRAELARMKTLENEEEIKNLEKELSDLENKLGKK"
gene <217362..>219878
/gene="USA1"
/locus_tag="YML029W"
/db_xref="GeneID:854979"
mRNA <217362..>219878
/gene="USA1"
/locus_tag="YML029W"
/product="Usa1p"
/transcript_id="NM_001182387.1"
/db_xref="GeneID:854979"
CDS 217362..219878
/gene="USA1"
/locus_tag="YML029W"
/experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p
ubiquitin ligase ERAD-L complex [PMID:16873066]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0060090 molecular
adaptor activity [PMID:20005842]"
/experiment="EXISTENCE:direct assay:GO:1902499 positive
regulation of protein autoubiquitination [PMID:31713515]"
/experiment="EXISTENCE:genetic interaction:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:16873066]"
/experiment="EXISTENCE:mutant phenotype:GO:0000839 Hrd1p
ubiquitin ligase ERAD-L complex [PMID:16873066]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:16873066]"
/experiment="EXISTENCE:physical interaction:GO:0000398
mRNA splicing, via spliceosome [PMID:11425851]"
/experiment="EXISTENCE:physical interaction:GO:0005789
endoplasmic reticulum membrane [PMID:16873066]"
/experiment="EXISTENCE:physical interaction:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:16873066]"
/note="Scaffold subunit of the Hrd1p ubiquitin ligase;
also promotes ligase oligomerization; involved in
ER-associated protein degradation (ERAD); interacts with
the U1 snRNP-specific protein, Snp1p"
/codon_start=1
/product="Usa1p"
/protein_id="NP_013683.1"
/db_xref="GeneID:854979"
/db_xref="SGD:S000004491"
/translation="MSEYLAQTPCKFTIWSSEIDLIRTNLLVNAHPLSTVGRLLQYIH
YQIYKQLRAIYQPEEQCTNSEIPHTPLNSINTYFLSYEGRELSATCLLKDITSSSHPD
SNHFIRLQLEKRTSPSGSAFDLEYDMEGEFNSMNIQFEINTLSSQRIFNSMEPNLPIG
TTLARLEKLALERIKDFEKSAGNLCGIKEDHSVSDLQGFIIKGKQTPMFLNYGSDSDY
YKDLNLVDLIGIDFAPAHNSFFTFLFKMNHEQNSHIANDEERFVLEFISDATLSITQM
NVKPDTTVKQVKDFICSVYTHSLNLRRNDIKLIYKGQLLHENNFAGNSSKISEYIKEP
HEVKVHVQINQEYTESGPGFWNEVFNNPNIFQFMPPDTRSQSPVSFAPTQGRSPAAIR
GEERGIPYVTESGNDIVPTDELYRKCIINGDEVVFIPVSELNPQSSYLSVIKGDYGEI
KIPISSNDYRINGDNILLSPSAIEQLESALNFKIERPRDSTLLHPSGEHVRAADNTSS
ANDNNTVENDESAWNRRVVRPLRNSFPLLLVLIRTFYLIGYNSLVPFFIILEFGSFLP
WKYIILLSLLFIFRTVWNTQEVWNLWRDYLHLNEIDEVKFSQIKEFINSNSLTLNFYK
KCKDTQSAIDLLMIPNLHEQRLSVYSKYDIEYDTNTPDVGQLNLLFIKVLSGEIPKDA
LDELFKEFFELYETTRNMNTLYPQDSLNELLLMIWKESQKKDINTLPKYRRWFQTLCS
QIAEHNVLDVVLRYIIPDPVNDRVITAVIKNFVLFWVTLLPYVKEKLDDIVAQRARDR
EQPAPSAQQQENEDEALIIPDEEEPTATGAQPHLYIPDED"
gene <220138..>220728
/gene="TSA1"
/locus_tag="YML028W"
/gene_synonym="TPX1; ZRG14"
/db_xref="GeneID:854980"
mRNA <220138..>220728
/gene="TSA1"
/locus_tag="YML028W"
/gene_synonym="TPX1; ZRG14"
/product="thioredoxin peroxidase TSA1"
/transcript_id="NM_001182386.1"
/db_xref="GeneID:854980"
CDS 220138..220728
/gene="TSA1"
/locus_tag="YML028W"
/gene_synonym="TPX1; ZRG14"
/EC_number="1.11.1.24"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10681558|PMID:22842922|PMID:8344960]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:18271751]"
/experiment="EXISTENCE:direct assay:GO:0005844 polysome
[PMID:18271751]"
/experiment="EXISTENCE:direct assay:GO:0006457 protein
folding [PMID:15163410]"
/experiment="EXISTENCE:direct assay:GO:0008379 thioredoxin
peroxidase activity [PMID:7961686|PMID:9799566]"
/experiment="EXISTENCE:direct assay:GO:0034599 cellular
response to oxidative stress [PMID:8344960]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:18271751]"
/experiment="EXISTENCE:direct assay:GO:0045454 cell redox
homeostasis [PMID:8344960]"
/experiment="EXISTENCE:direct assay:GO:0051082 unfolded
protein binding [PMID:15163410]"
/experiment="EXISTENCE:direct assay:GO:0051920
peroxiredoxin activity [PMID:17210445]"
/experiment="EXISTENCE:genetic interaction:GO:0000077 DNA
damage checkpoint signaling [PMID:19851444]"
/experiment="EXISTENCE:genetic interaction:GO:0034599
cellular response to oxidative stress [PMID:15051715]"
/experiment="EXISTENCE:mutant phenotype:GO:0006111
regulation of gluconeogenesis [PMID:27634403]"
/experiment="EXISTENCE:mutant phenotype:GO:0006457 protein
folding [PMID:16251355]"
/experiment="EXISTENCE:mutant phenotype:GO:0008379
thioredoxin peroxidase activity
[PMID:7961686|PMID:9799566]"
/experiment="EXISTENCE:mutant phenotype:GO:0019207 kinase
regulator activity [PMID:27634403]"
/experiment="EXISTENCE:mutant phenotype:GO:0033194
response to hydroperoxide [PMID:15210711]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress
[PMID:18271751|PMID:8344960]"
/experiment="EXISTENCE:mutant phenotype:GO:0042262 DNA
protection [PMID:19543365]"
/experiment="EXISTENCE:mutant phenotype:GO:0045454 cell
redox homeostasis [PMID:9799566|PMID:8344960]"
/experiment="EXISTENCE:mutant phenotype:GO:0051082
unfolded protein binding [PMID:16251355]"
/experiment="EXISTENCE:mutant phenotype:GO:0061077
chaperone-mediated protein folding [PMID:24022485]"
/note="Thioredoxin peroxidase; acts as both
ribosome-associated and free cytoplasmic antioxidant;
self-associates to form a HMW chaperone complex under
oxidative stress; chaperone activity essential for growth
in zinc deficiency; hydrogen peroxide receptor and signal
transducer in a light sensing pathway; required for
telomere length maintenance; binds and modulates Cdc19p
activity; protein abundance increases and forms
cytoplasmic foci during DNA replication stress"
/codon_start=1
/product="thioredoxin peroxidase TSA1"
/protein_id="NP_013684.1"
/db_xref="GeneID:854980"
/db_xref="SGD:S000004490"
/translation="MVAQVQKQAPTFKKTAVVDGVFDEVSLDKYKGKYVVLAFIPLAF
TFVCPTEIIAFSEAAKKFEEQGAQVLFASTDSEYSLLAWTNIPRKEGGLGPINIPLLA
DTNHSLSRDYGVLIEEEGVALRGLFIIDPKGVIRHITINDLPVGRNVDEALRLVEAFQ
WTDKNGTVLPCNWTPGAATIKPTVEDSKEYFEAANK"
gene <221406..>222563
/gene="YOX1"
/locus_tag="YML027W"
/db_xref="GeneID:854981"
mRNA <221406..>222563
/gene="YOX1"
/locus_tag="YML027W"
/product="Yox1p"
/transcript_id="NM_001182385.1"
/db_xref="GeneID:854981"
CDS 221406..222563
/gene="YOX1"
/locus_tag="YML027W"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:12464632]"
/experiment="EXISTENCE:direct assay:GO:0000977 RNA
polymerase II transcription regulatory region
sequence-specific DNA binding
[PMID:20385087|PMID:12464633]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:15282802|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding [PMID:19158363]"
/experiment="EXISTENCE:genetic interaction:GO:0071930
negative regulation of transcription involved in G1/S
transition of mitotic cell cycle [PMID:12464633]"
/experiment="EXISTENCE:mutant phenotype:GO:0000977 RNA
polymerase II transcription regulatory region
sequence-specific DNA binding [PMID:12464633]"
/experiment="EXISTENCE:mutant phenotype:GO:0071930
negative regulation of transcription involved in G1/S
transition of mitotic cell cycle
[PMID:12464633|PMID:17314407]"
/note="Homeobox transcriptional repressor; binds to Mcm1p
and to early cell cycle boxes (ECBs) in the promoters of
cell cycle-regulated genes expressed in M/G1 phase;
expression is cell cycle-regulated; phosphorylated by
Cdc28p; relocalizes from nucleus to cytoplasm upon DNA
replication stress; YOX1 has a paralog, YHP1, that arose
from the whole genome duplication"
/codon_start=1
/product="Yox1p"
/protein_id="NP_013685.1"
/db_xref="GeneID:854981"
/db_xref="SGD:S000004489"
/translation="MSQETKMLPSLSSLLSGTEISSSPVSPSFTNPRTSFHLDDRGTI
KLPPLNTSINRPRSVESALRHTVTSLHENSSAYGDDMLKHTQSDSALSSQLNSSQETV
DESHENLLLTPLNSKKRDYSVSSKKNDILTPLSAAKSIIIPSASKEKRRAFAFITHSQ
ETFPKKEPKIDNAPLARRKRRRTSSQELSILQAEFEKCPAPSKEKRIELAESCHMTEK
AVQIWFQNKRQAVKRQRIATSKSTTIIQTVSPPSPPLDVHATPLASRVKADILRDGSS
CSRSSSSSPLENTPPRPHHSLNRRSSTPSIKRSQALTFHLNPQKKTLTPVKTSPNSRV
NKLINSIDHSPSKAKRPVSNPSGSPKRKRKFGFKIVDQQPLKDLDPNAFRG"
gene complement(<222987..>223828)
/gene="RPS18B"
/locus_tag="YML026C"
/db_xref="GeneID:854982"
mRNA complement(join(<222987..223380,223782..>223828))
/gene="RPS18B"
/locus_tag="YML026C"
/product="ribosomal 40S subunit protein S18B"
/transcript_id="NM_001182384.1"
/db_xref="GeneID:854982"
CDS complement(join(222987..223380,223782..223828))
/gene="RPS18B"
/locus_tag="YML026C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961]"
/experiment="EXISTENCE:genetic interaction:GO:0006407 rRNA
export from nucleus [PMID:16246728]"
/experiment="EXISTENCE:mutant phenotype:GO:0000447
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from
5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]"
/note="Protein component of the small (40S) ribosomal
subunit; homologous to mammalian ribosomal protein S18 and
bacterial S13; RPS18B has a paralog, RPS18A, that arose
from the whole genome duplication; protein abundance
increases in response to DNA replication stress"
/codon_start=1
/product="ribosomal 40S subunit protein S18B"
/protein_id="NP_013686.1"
/db_xref="GeneID:854982"
/db_xref="SGD:S000004488"
/translation="MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSN
LVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLA
NNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQHTKTTGRRRA"
gene complement(<224406..>225365)
/gene="YML6"
/locus_tag="YML025C"
/gene_synonym="uL4m"
/db_xref="GeneID:854983"
mRNA complement(join(<224406..225239,225339..>225365))
/gene="YML6"
/locus_tag="YML025C"
/gene_synonym="uL4m"
/product="mitochondrial 54S ribosomal protein YmL6"
/transcript_id="NM_001182383.1"
/db_xref="GeneID:854983"
CDS complement(join(224406..225239,225339..225365))
/gene="YML6"
/locus_tag="YML025C"
/gene_synonym="uL4m"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:9151978]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:9151978]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005762
mitochondrial large ribosomal subunit [PMID:9151978]"
/note="Mitochondrial ribosomal protein of the large
subunit; has similarity to E. coli L4 ribosomal protein
and human mitoribosomal MRP-L4 protein; essential for
viability, unlike most other mitoribosomal proteins"
/codon_start=1
/product="mitochondrial 54S ribosomal protein YmL6"
/protein_id="NP_013687.1"
/db_xref="GeneID:854983"
/db_xref="SGD:S000004487"
/translation="MTIKRNLVKTLQSIRYQATTATAHAESTLNPLPNAAIPPKYALV
TVRSFPSLEPLTFVPVPTSTVAAPLRRDILWRAVVYENDNRRVGASNPPGRSENGFSR
RKLMPQKGSGRARVGDANSPTRHNGGRALARTAPNDYTTELPSKVYSMAFNNALSHQY
KSGKLFVIGGEKVDLISPTPELDLNRLDLVNTNTVEGKEIFEGEVIFRKFLEEFQLKG
KRLLFITDKTREGLIKSSDPYKQKVDVIQKELVEVNDILRAQAVFIELEALEYLAMAH
QKEILHSVSN"
gene <225889..>226697
/gene="RPS17A"
/locus_tag="YML024W"
/gene_synonym="RP51A; RPL51A"
/db_xref="GeneID:854984"
mRNA join(<225889..225891,226290..>226697)
/gene="RPS17A"
/locus_tag="YML024W"
/gene_synonym="RP51A; RPL51A"
/product="ribosomal 40S subunit protein S17A"
/transcript_id="NM_001182382.1"
/db_xref="GeneID:854984"
CDS join(225889..225891,226290..226697)
/gene="RPS17A"
/locus_tag="YML024W"
/gene_synonym="RP51A; RPL51A"
/experiment="EXISTENCE:mutant phenotype:GO:0000028
ribosomal small subunit assembly [PMID:3915776]"
/note="Ribosomal protein 51 (rp51) of the small (40s)
subunit; homologous to mammalian ribosomal protein S17, no
bacterial homolog; RPS17A has a paralog, RPS17B, that
arose from the whole genome duplication"
/codon_start=1
/product="ribosomal 40S subunit protein S17A"
/protein_id="NP_013688.1"
/db_xref="GeneID:854984"
/db_xref="SGD:S000004486"
/translation="MGRVRTKTVKRASKALIERYYPKLTLDFQTNKRLCDEIATIQSK
RLRNKIAGYTTHLMKRIQKGPVRGISFKLQEEERERKDQYVPEVSALDLSRSNGVLNV
DNQTSDLVKSLGLKLPLSVINVSAQRDRRYRKRV"
gene complement(<226994..>228664)
/gene="NSE5"
/locus_tag="YML023C"
/db_xref="GeneID:854985"
mRNA complement(<226994..>228664)
/gene="NSE5"
/locus_tag="YML023C"
/product="Smc5-Smc6 complex subunit NSE5"
/transcript_id="NM_001182381.1"
/db_xref="GeneID:854985"
CDS complement(226994..228664)
/gene="NSE5"
/locus_tag="YML023C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14690591]"
/experiment="EXISTENCE:direct assay:GO:0019789 SUMO
transferase activity [PMID:15738391]"
/experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6
complex [PMID:15738391]"
/experiment="EXISTENCE:direct assay:GO:0042030 ATPase
inhibitor activity [PMID:34191293]"
/experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
repair [PMID:15738391]"
/note="Component of the SMC5-SMC6 complex; this complex
plays a key role in the removal of X-shaped DNA structures
that arise between sister chromatids during DNA
replication and repair"
/codon_start=1
/product="Smc5-Smc6 complex subunit NSE5"
/protein_id="NP_013689.1"
/db_xref="GeneID:854985"
/db_xref="SGD:S000004485"
/translation="MDGALINSVLYVSPRNGAHYFVELTEKHLLAFEMLNSMCLLENY
DHVLLFLECQFGKSHNLAVIPFDIILVLFTLSTLSEYYKEPILRANDPYNTSRETLSR
RALKLLQKYLAILKEFDSEQYNLYDLELLRCQFFLAIDTLTPKKQKWGFDRFRRTKSE
SGVTYRQNASVDPELDQAKTFKNPYRSYISCLEQRNTILGNRLLNLKLNEPGEFINMI
LWTLSNSLQESTPLFLSSHEIWMPLLEILIDLFSCRQDYFIQHEVAQNVSKSLFVQRL
SESPLAVFFESLNTRNFANRFSEYVFLNCDYKLPSDNYATPVHPVYNGENTIVDTYIP
TIKCSPLYKSQKSLALRRKLIGSCFKLLLRVPDGHRLITPRIVADDVIQGISRTLASF
NDILQFKKFFMTENLSQESYFIPLLAEGTLSEILKDTQECVVILTLVENLSDGVSFCN
EVIGLVKSKCFAFTEQCSQASYEEAVLNIEKCDVCLLVLLRYLLHLIGTEAILDAKEQ
LEMLHAIEKNDSGRRQWAKALNLGNDPPLLYPIVSQMFGVHDKSVIIE"
gene <228937..>229500
/gene="APT1"
/locus_tag="YML022W"
/db_xref="GeneID:854986"
mRNA <228937..>229500
/gene="APT1"
/locus_tag="YML022W"
/product="adenine phosphoribosyltransferase APT1"
/transcript_id="NM_001182380.1"
/db_xref="GeneID:854986"
CDS 228937..229500
/gene="APT1"
/locus_tag="YML022W"
/EC_number="2.4.2.7"
/experiment="EXISTENCE:direct assay:GO:0003999 adenine
phosphoribosyltransferase activity [PMID:9864350]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0006168 adenine
salvage [PMID:9864350]"
/note="Adenine phosphoribosyltransferase; catalyzes the
formation of AMP from adenine and
5-phosphoribosylpyrophosphate; involved in the salvage
pathway of purine nucleotide biosynthesis; APT1 has a
paralog, APT2, that arose from the whole genome
duplication"
/codon_start=1
/product="adenine phosphoribosyltransferase APT1"
/protein_id="NP_013690.1"
/db_xref="GeneID:854986"
/db_xref="SGD:S000004484"
/translation="MSIASYAQELKLALHQYPNFPSEGILFEDFLPIFRNPGLFQKLI
DAFKLHLEEAFPEVKIDYIVGLESRGFLFGPTLALALGVGFVPVRKAGKLPGECFKAT
YEKEYGSDLFEIQKNAIPAGSNVIIVDDIIATGGSAAAAGELVEQLEANLLEYNFVME
LDFLKGRSKLNAPVFTLLNAQKEALKK"
gene complement(<229734..>230813)
/gene="UNG1"
/locus_tag="YML021C"
/db_xref="GeneID:854987"
mRNA complement(<229734..>230813)
/gene="UNG1"
/locus_tag="YML021C"
/product="uracil-DNA glycosylase"
/transcript_id="NM_001182379.1"
/db_xref="GeneID:854987"
CDS complement(229734..230813)
/gene="UNG1"
/locus_tag="YML021C"
/EC_number="3.2.2.27"
/experiment="EXISTENCE:direct assay:GO:0004844 uracil DNA
N-glycosylase activity [PMID:2644266]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11812822|PMID:24034606]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:11812822|PMID:24034606]"
/experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
repair [PMID:1938887]"
/note="Uracil-DNA glycosylase; required for repair of
uracil in DNA formed by spontaneous cytosine deamination;
efficiently excises uracil from single-stranded DNA in
vivo; not required for strand-specific mismatch repair;
cell-cycle regulated, expressed in late G1; localizes to
mitochondria and nucleus"
/codon_start=1
/product="uracil-DNA glycosylase"
/protein_id="NP_013691.1"
/db_xref="GeneID:854987"
/db_xref="SGD:S000004483"
/translation="MWCMRRLPTNSVMTVARKRKQTTIEDFFGTKKSTNEAPNKKGKS
GATFMTITNGAAIKTETKAVAKEANTDKYPANSNAKDVYSKNLSSNLRTLLSLELETI
DDSWFPHLMDEFKKPYFVKLKQFVTKEQADHTVFPPAKDIYSWTRLTPFNKVKVVIIG
QDPYHNFNQAHGLAFSVKPPTPAPPSLKNIYKELKQEYPDFVEDNKVGDLTHWASQGV
LLLNTSLTVRAHNANSHSKHGWETFTKRVVQLLIQDREADGKSLVFLLWGNNAIKLVE
SLLGSTSVGSGSKYPNIMVMKSVHPSPLSASRGFFGTNHFKMINDWLYNTRGEKMIDW
SVVPGTSLREVQEANARLESESKDP"
gene <231149..>233143
/locus_tag="YML020W"
/db_xref="GeneID:854988"
mRNA <231149..>233143
/locus_tag="YML020W"
/product="uncharacterized protein"
/transcript_id="NM_001182378.1"
/db_xref="GeneID:854988"
CDS 231149..233143
/locus_tag="YML020W"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013692.1"
/db_xref="GeneID:854988"
/db_xref="SGD:S000004482"
/translation="MVTTPLHSSPKSSLKSSTTSLRSVHTQSGRMGPSEPKHRTTKSW
SIWGGNDEEEPELSNKNKGKETAQDNSQENDNVSNEGTRLHDNQQTTILKETTRIEKG
EKDKKDRNAAIVEKNTRPRAWPFFWGRNKKDPEPTHNIPTDADNNTLSRLANSLNPAP
LTNTYIPYKPDAILIRDKGVKTAKKLTDDIGNQFPNIVVPSFDILPKQTIWNTVTSTI
WKWKTEYWDRRPSSRVREGEEQVQHSQNQLKEETNTVANEAKDEERLEHNRGSLFRVD
PWKKINLLSDYQSRPIRVLIVGVHGFFPTKIIRPFIGEPTGTSTKFVTEAEEIVKEYF
DQHKVPIEISKIALEREGEIFDRVDFFYEVMKHWSKEINNSDFIYFVSHSQGCPVTIM
LLAKLIKNGIINLDNSQFFNDEIQFCSSKKIISVLAMAGINNGPFYGADQTLFVRAYQ
TIEKDSLRELFEFQKFDSKQSQSFIEGLRTIISNNVKITFVGSINDQLVPLYSSTCLF
ANHPNIFRAIFIDRGSQTPAFITRIVKIAGSLLNLGYNDHGIIKEISGSLAGTLTGGG
HSTIYNEKQVYHLGIKFALETTDLSEMYPIEYSPYKLSELGANPYRLPWCMRGLMYES
NKHFSNEEIKMLFKEFEEWEPETKQLKDIKNRLNGLKYRL"
gene <233457..>234455
/gene="OST6"
/locus_tag="YML019W"
/db_xref="GeneID:854989"
mRNA <233457..>234455
/gene="OST6"
/locus_tag="YML019W"
/product="dolichyl-diphosphooligosaccharide--protein
glycotransferase"
/transcript_id="NM_001182377.1"
/db_xref="GeneID:854989"
CDS 233457..234455
/gene="OST6"
/locus_tag="YML019W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0008250
oligosaccharyltransferase complex [PMID:10358084]"
/experiment="EXISTENCE:direct assay:GO:0015035
protein-disulfide reductase activity [PMID:23416356]"
/experiment="EXISTENCE:genetic interaction:GO:0006487
protein N-linked glycosylation [PMID:10358084]"
/experiment="EXISTENCE:genetic interaction:GO:0065003
protein-containing complex assembly [PMID:10358084]"
/note="Subunit of the oligosaccharyltransferase complex of
the ER lumen; complex catalyzes asparagine-linked
glycosylation of newly synthesized proteins; similar to
and partially functionally redundant with Ost3p"
/codon_start=1
/product="dolichyl-diphosphooligosaccharide--protein
glycotransferase"
/protein_id="NP_013693.1"
/db_xref="GeneID:854989"
/db_xref="SGD:S000004481"
/translation="MKWCSTYIIIWLAIIFHKFQKSTATASHNIDDILQLKDDTGVIT
VTADNYPLLSRGVPGYFNILYITMRGTNSNGMSCQLCHDFEKTYHAVADVIRSQAPQS
LNLFFTVDVNEVPQLVKDLKLQNVPHLVVYPPAESNKQSQFEWKTSPFYQYSLVPENA
ENTLQFGDFLAKILNISITVPQAFNVQEFVYYFVACMVVFIFIKKVILPKVTNKWKLF
SMILSLGILLPSITGYKFVEMNAIPFIARDAKNRIMYFSGGSGWQFGIEIFSVSLMYI
VMSALSVLLIYVPKISCVSEKMRGLLSSFLACVLFYFFSYFISCYLIKNPGYPIVF"
gene complement(<234771..>235952)
/locus_tag="YML018C"
/db_xref="GeneID:854990"
mRNA complement(<234771..>235952)
/locus_tag="YML018C"
/product="uncharacterized protein"
/transcript_id="NM_001182376.1"
/db_xref="GeneID:854990"
CDS complement(234771..235952)
/locus_tag="YML018C"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane
[PMID:14562095|PMID:22842922|PMID:26928762]"
/note="hypothetical protein; green fluorescent protein
(GFP)-fusion protein localizes to the membrane of the
vacuole; physical interaction with Atg27p suggests a
possible role in autophagy; YML018C is not an essential
gene; relative distribution to the vacuolar membrane
decreases upon DNA replication stress; YML018C has a
paralog, THI74, that arose from the whole genome
duplication"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013694.1"
/db_xref="GeneID:854990"
/db_xref="SGD:S000004480"
/translation="MVSKDQTSFNKRWTLGLLMLGLVIILWVLSSFLINLIFEDDSYR
KPFFITYTNTAAFIFYLFPTAKAVVVNYKDTGRANVHRELIMEEEGTGSDSNRSVDMT
SPLLTNLEAGTHANQKKRLTLYETIKLSAEFCILWFTANLVTNASLAFTSVASQTILS
TTSSFFTLFIGAICHVESLSKSKVLGSFISFVGIIMVTKSDSHQRYQRHIADVSGDDN
DAVQVLIGNLLALAGAVLYGVYSTLLKREVGDETRVNMKIFFGFVGLFNLLFLWPSLI
VLDFFGWEPFSLPKDPKVVVIIFVNCLITFVSDFCWAKAMLLTSPLTVTVGLSITIPL
AMFGDVIFKHKTMSALYLFGATLILGSFFIINKSSEEEHFENSITASNYESVEVPAAN
N"
gene <236588..>238731
/gene="PSP2"
/locus_tag="YML017W"
/gene_synonym="MRS15"
/db_xref="GeneID:854991"
mRNA join(<236588..236591,236954..>238731)
/gene="PSP2"
/locus_tag="YML017W"
/gene_synonym="MRS15"
/product="Psp2p"
/transcript_id="NM_001182375.1"
/db_xref="GeneID:854991"
CDS join(236588..236591,236954..238731)
/gene="PSP2"
/locus_tag="YML017W"
/gene_synonym="MRS15"
/experiment="EXISTENCE:direct assay:GO:0000932 P-body
[PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="Asn rich cytoplasmic protein with a role in
clathrin suppresion; contains RGG motifs; high-copy
suppressor of group II intron-splicing defects of a
mutation in MRS2 and of a conditional mutation in POL1
(DNA polymerase alpha); possible role in mitochondrial
mRNA splicing"
/codon_start=1
/product="Psp2p"
/protein_id="NP_013695.2"
/db_xref="GeneID:854991"
/db_xref="SGD:S000004479"
/translation="MGTNNTSNNNGTTKKMSLEEFLGNDTLGESVWDEEDINLDAISN
TTNIDILKQTKAGEHQRDGHQQHPHGGHGPMNRSRFSNAGPFGGGSMGDFANHHHPLQ
HQQGPPYIVKFSDLPPRFSNFDIEDLFQAKFTKFIKFKLFWEINKNPSISTLKSGSIF
DQNFKRDSKVAFVELYTSRDMDKILNYWTTPLKEIYHITTAPAEFEDFKDYSTKVKLL
TDPKDDAGKPFITKTQRSKSNPFGSAKPVDTQSKILDIEEKMENLHVEDTTTLRASLI
PSSDSMATTATGSKITILKKQTPTEEESHSATPTPKPLSYSEVVERSVVNETSKKGTP
LSKLDSPALELQSKPDKSDEFKGGDEQGFEKGGDDKAQLDVSNDKDKGSETDVDKQFT
FKNVEREHSMSRTKYNGNHNNNNGNFRGSNRYRGGPNGSSYKGGHNNRGNRGGYRGGS
SYNNNNNNTNDNNNNNNNSSSNNNNGSRYHDRQNNEEGLTSDSSLDASGNKKNDFTNS
TSNTQQYSIFKPASGFLGQGNNDSIRNNGRGNYNSSGMNGGSRGRGFGRGRGFGRGAY
NNRGSRGGRGSSGNYSNYNNRTTDMPL"
gene complement(<239458..>241536)
/gene="PPZ1"
/locus_tag="YML016C"
/db_xref="GeneID:854992"
mRNA complement(<239458..>241536)
/gene="PPZ1"
/locus_tag="YML016C"
/product="salt homeostasis regulator"
/transcript_id="NM_001182374.1"
/db_xref="GeneID:854992"
CDS complement(239458..241536)
/gene="PPZ1"
/locus_tag="YML016C"
/EC_number="3.1.3.16"
/experiment="EXISTENCE:direct assay:GO:0004722 protein
serine/threonine phosphatase activity [PMID:7615085]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276|PMID:8824289]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:mutant phenotype:GO:0006883
intracellular sodium ion homeostasis [PMID:7768897]"
/experiment="EXISTENCE:mutant phenotype:GO:0008104 protein
localization [PMID:21237705]"
/note="Serine/threonine protein phosphatase Z, isoform of
Ppz2p; involved in regulation of potassium transport,
which affects osmotic stability, cell cycle progression,
and halotolerance"
/codon_start=1
/product="salt homeostasis regulator"
/protein_id="NP_013696.1"
/db_xref="GeneID:854992"
/db_xref="SGD:S000004478"
/translation="MGNSSSKSSKKDSHSNSSSRNPRPQVSRTETSHSVKSAKSNKSS
RSRRSLPSSSTTNTNSNVPDPSTPSKPNLEVNHQRHSSHTNRYHFPSSSHSHSNSQNE
LLTTPSSSSTKRPSTSRRSSYNTKAAADLPPSMIQMEPKSPILKTNNSSTHVSKHKSS
YSSTYYENALTDDDNDDKDNDISHTKRFSRSSNSRPSSIRSGSVSRRKSDVTHEEPNN
GSYSSNNQENYLVQALTRSNSHASSLHSRKSSFGSDGNTAYSTPLNSPGLSKLTDHSG
EYFTSNSTSSLNHHSSRDIYPSKHISNDDDIENSSQLSNIHASMENVNDKNNNITDSK
KDPNEEFNDIMQSSGNKNAPKKFKKPIDIDETIQKLLDAGYAAKRTKNVCLKNNEILQ
ICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVD
RGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFI
DTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTD
SPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSA
PNYCGEFDNWGAVMSVSEGLLCSFELLDPLDSAALKQVMKKGRQERKLANQQQQMMET
SITNDNESQQ"
gene complement(<241989..>243029)
/gene="TAF11"
/locus_tag="YML015C"
/gene_synonym="TAF40"
/db_xref="GeneID:854993"
mRNA complement(<241989..>243029)
/gene="TAF11"
/locus_tag="YML015C"
/gene_synonym="TAF40"
/product="TATA-binding protein-associated factor TAF11"
/transcript_id="NM_001182373.1"
/db_xref="GeneID:854993"
CDS complement(241989..243029)
/gene="TAF11"
/locus_tag="YML015C"
/gene_synonym="TAF40"
/experiment="EXISTENCE:direct assay:GO:0003682 chromatin
binding [PMID:10818000]"
/experiment="EXISTENCE:direct assay:GO:0005669
transcription factor TFIID complex
[PMID:10788514|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0006366
transcription by RNA polymerase II
[PMID:12138208|PMID:15448131]"
/experiment="EXISTENCE:mutant phenotype:GO:0006366
transcription by RNA polymerase II [PMID:9083082]"
/experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
polymerase II preinitiation complex assembly
[PMID:12840001]"
/note="TFIID subunit (40 kDa); involved in RNA polymerase
II transcription initiation, similar to histone H3 with
atypical histone fold motif of Spt3-like transcription
factors"
/codon_start=1
/product="TATA-binding protein-associated factor TAF11"
/protein_id="NP_013697.1"
/db_xref="GeneID:854993"
/db_xref="SGD:S000004477"
/translation="MTEPQGPLDTIPKVNYPPILTIANYFSTKQMIDQVISEDQDYVT
WKLQNLRTGGTSINNQLNKYPKYKYQKTRINQQDPDSINKVPENLIFPQDILQQQTQN
SNYEDTNTNEDENEKLAQDEQFKLLVTNLDKDQTNRFEVFHRTSLNKTQVKKLASTVA
NQTISENIRVFLQAVGKIYAGEIIELAMIVKNKWLTSQMCIEFDKRTKIGYKLKKYLK
KLTFSIIENQQYKQDYQSDSVPEDEPDFYFDDEEVDKRETTLGNSLLQSKSLQQSDHN
SQDLKLQLIEQYNKLVLQFNKLDVSIEKYNNSPLLPEHIREAWRLYRLQSDTLPNAYW
RTQGEGQGSMFR"
gene <243225..>244064
/gene="TRM9"
/locus_tag="YML014W"
/gene_synonym="KTI1"
/db_xref="GeneID:854994"
mRNA <243225..>244064
/gene="TRM9"
/locus_tag="YML014W"
/gene_synonym="KTI1"
/product="tRNA
(carboxymethyluridine(34)-5-O)-methyltransferase"
/transcript_id="NM_001182372.1"
/db_xref="GeneID:854994"
CDS 243225..244064
/gene="TRM9"
/locus_tag="YML014W"
/gene_synonym="KTI1"
/EC_number="2.1.1.229"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14645538]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:14645538]"
/experiment="EXISTENCE:direct assay:GO:0016300 tRNA
(uracil) methyltransferase activity [PMID:14645538]"
/experiment="EXISTENCE:direct assay:GO:0030488 tRNA
methylation [PMID:14645538]"
/experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA
wobble uridine modification [PMID:18755837]"
/experiment="EXISTENCE:mutant phenotype:GO:0006448
regulation of translational elongation [PMID:27245397]"
/note="tRNA methyltransferase; catalyzes modification of
wobble bases in tRNA anticodons to 2,
5-methoxycarbonylmethyluridine and
5-methoxycarbonylmethyl-2-thiouridine; may act as part of
a complex with Trm112p; deletion mutation increases
translational infidelity, including amino acid
misincorporation and -1 frameshifting, and also confers
resistance to zymocin; null mutant displays activation of
stress responses"
/codon_start=1
/product="tRNA
(carboxymethyluridine(34)-5-O)-methyltransferase"
/protein_id="NP_013698.1"
/db_xref="GeneID:854994"
/db_xref="SGD:S000004476"
/translation="MEINQAAEKEQEYVHKVYNEIAPHFSQTRYKPWPIVTQFLKTRP
MGSIGIDVGCGNGKYLGVNPDIYIIGSDRSDGLIECARGINPSYNLLVADGLNLPHKN
ETFDFAISIAVVHHWSTRERRVEVIRHVLSKLRQGGQALIYCWALEQGSSRRGYHEGM
EQDVFVPWVLPKSKSKPKTKSTPPAKVKTRPKPNLMNIPPKERSEYLQRWKEEQQRSK
SLDDNDEKQQQDQEQEREEVKYRYYHLYREGELAEDCRQAGAAVHSEGFERDNWWVVA
QKR"
gene <244149..>245903
/gene="UBX2"
/locus_tag="YML013W"
/gene_synonym="SEL1"
/db_xref="GeneID:854995"
mRNA <244149..>245903
/gene="UBX2"
/locus_tag="YML013W"
/gene_synonym="SEL1"
/product="Ubx2p"
/transcript_id="NM_001182371.1"
/db_xref="GeneID:854995"
CDS 244149..245903
/gene="UBX2"
/locus_tag="YML013W"
/gene_synonym="SEL1"
/experiment="EXISTENCE:direct assay:GO:0000837 Doa10p
ubiquitin ligase complex [PMID:16873066]"
/experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p
ubiquitin ligase ERAD-L complex
[PMID:16873065|PMID:16873066]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:16179952]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:22454508|PMID:24868093]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16179953]"
/experiment="EXISTENCE:direct assay:GO:0030674
protein-macromolecule adaptor activity [PMID:31118508]"
/experiment="EXISTENCE:genetic interaction:GO:0034389
lipid droplet organization [PMID:22454508]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:16179952]"
/experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid
droplet organization [PMID:22454508]"
/experiment="EXISTENCE:mutant phenotype:GO:0034982
mitochondrial protein processing [PMID:31118508]"
/experiment="EXISTENCE:mutant phenotype:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:15258615]"
/experiment="EXISTENCE:mutant phenotype:GO:0072671
mitochondria-associated ubiquitin-dependent protein
catabolic process [PMID:32118579]"
/experiment="EXISTENCE:physical interaction:GO:0030433
ubiquitin-dependent ERAD pathway
[PMID:16179952|PMID:16919153]"
/experiment="EXISTENCE:physical interaction:GO:0030674
protein-macromolecule adaptor activity [PMID:16179952]"
/note="Bridging factor involved in ER-associated protein
degradation (ERAD); bridges the cytosolic
Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane
associated Ssm4p and Hrd1p ubiquitin ligase complexes;
contains a UBX (ubiquitin regulatory X) domain and a
ubiquitin-associated (UBA) domain; redistributes from the
ER to lipid droplets during the diauxic shift and
stationary phase; required for the maintenance of lipid
homeostasis; required for mitochondrial protein
translocation-associated degradation"
/codon_start=1
/product="Ubx2p"
/protein_id="NP_013699.1"
/db_xref="GeneID:854995"
/db_xref="SGD:S000004475"
/translation="MPVVNHEDSEFHLSHTEEDKLNEFQVITNFPPEDLPDVVRLLRN
HGWQLEPALSRYFDGEWKGEPDQMGEPTQTSTPMAETLVPPALGPRPLLFTASLPVVR
PLPANFRNDFRTIGLNGRSNTVWSMFESFSYDGNPFLFILLLIPRIINRLSATIFTFF
CTLLSLHSISGGGNSGKPKISKVPKAPTRETHIPLAEILGDTKDKDAFCELKSFKPDI
SFNEALRIAKEEFKFMLLILVGDTYDTDTDTVDVNSKLLLEKILLNKKTLQYLRKIDN
DLIIYLKCVHELEPWLVARQLGVRNTPEIFLIANVANKASHSETLPSQRLSILGKLKV
NSLNRFLQSLTNVVEKYTPELVVNKTEMHELRMSREIKKLQEDAYKKSLEMDRIKAIE
KEKSLKHAQDLKLNSTARQLKWLKACIDEIQPFETTGKQATLQFRTSSGKRFVKKFPS
MTTLYQIYQSIGCHIYLAVYSSDPAEWSNALQDKIRQLSADDDMLCFKEGQLETATAT
TIEELGHIINNELTSFDLERGKLEFDFELVSPFPKYTVHPNEHMSVDQVPQLWPNGSL
LVEALDEEDEEDEENEEQ"
gene <246116..>246751
/gene="ERV25"
/locus_tag="YML012W"
/db_xref="GeneID:854997"
mRNA <246116..>246751
/gene="ERV25"
/locus_tag="YML012W"
/product="Erv25p"
/transcript_id="NM_001182369.1"
/db_xref="GeneID:854997"
CDS 246116..246751
/gene="ERV25"
/locus_tag="YML012W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0030134
COPII-coated ER to Golgi transport vesicle
[PMID:11157978]"
/experiment="EXISTENCE:physical interaction:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:18283113]"
/note="Member of the p24 family involved in ER to Golgi
transport; role in misfolded protein quality control;
forms a heterotrimeric complex with Erp1, Erp2p, and
Emp24"
/codon_start=1
/product="Erv25p"
/protein_id="NP_013701.1"
/db_xref="GeneID:854997"
/db_xref="SGD:S000004473"
/translation="MQVLQLWLTTLISLVVAVQGLHFDIAASTDPEQVCIRDFVTEGQ
LVVADIHSDGSVGDGQKLNLFVRDSVGNEYRRKRDFAGDVRVAFTAPSSTAFDVCFEN
QAQYRGRSLSRAIELDIESGAEARDWNKISANEKLKPIEVELRRVEEITDEIVDELTY
LKNREERLRDTNESTNRRVRNFSILVIIVLSSLGVWQVNYLKNYFKTKHII"
gene complement(<246895..>247428)
/gene="RAD33"
/locus_tag="YML011C"
/db_xref="GeneID:854998"
mRNA complement(<246895..>247428)
/gene="RAD33"
/locus_tag="YML011C"
/product="Rad33p"
/transcript_id="NM_001182368.1"
/db_xref="GeneID:854998"
CDS complement(246895..247428)
/gene="RAD33"
/locus_tag="YML011C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0006289
nucleotide-excision repair [PMID:16595192]"
/note="Protein involved in nucleotide excision repair;
green fluorescent protein (GFP)-fusion protein localizes
to the nucleus"
/codon_start=1
/product="Rad33p"
/protein_id="NP_013702.1"
/db_xref="GeneID:854998"
/db_xref="SGD:S000004472"
/translation="MSKSTNVSYERVELFENPKVPIEVEDEILEKYAESSLDHDMTVN
ELPRFFKDLQLEPTIWKLVRNEDVIIEGTDVIDFTKLVRCTCQLLILMNNLTVIDDLW
SMLIRNCGRDVDFPQVALRDHVLSVKDLQKISNLIGADQSSGTIEMISCATDGKRLFM
TYLDFGCVLGKLGYLKM"
gene <247677..>250868
/gene="SPT5"
/locus_tag="YML010W"
/db_xref="GeneID:854999"
mRNA <247677..>250868
/gene="SPT5"
/locus_tag="YML010W"
/product="transcription elongation factor SPT5"
/transcript_id="NM_001182366.1"
/db_xref="GeneID:854999"
CDS 247677..250868
/gene="SPT5"
/locus_tag="YML010W"
/experiment="EXISTENCE:direct assay:GO:0000245
spliceosomal complex assembly [PMID:31289129]"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:35102600]"
/experiment="EXISTENCE:direct assay:GO:0000993 RNA
polymerase II complex binding [PMID:26945063]"
/experiment="EXISTENCE:direct assay:GO:0001042 RNA
polymerase I core binding [PMID:21467036]"
/experiment="EXISTENCE:direct assay:GO:0001179 RNA
polymerase I general transcription initiation factor
binding [PMID:21467036]"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:26945063]"
/experiment="EXISTENCE:direct assay:GO:0003727
single-stranded RNA binding [PMID:27376968]"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:1840633]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0006338 chromatin
remodeling [PMID:35102600]"
/experiment="EXISTENCE:direct assay:GO:0010508 positive
regulation of autophagy [PMID:31462158]"
/experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA
binding [PMID:31289129]"
/experiment="EXISTENCE:direct assay:GO:0019843 rRNA
binding [PMID:21467036]"
/experiment="EXISTENCE:direct assay:GO:0030619 U1 snRNA
binding [PMID:31289129]"
/experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA
binding [PMID:31289129]"
/experiment="EXISTENCE:direct assay:GO:0030621 U4 snRNA
binding [PMID:31289129]"
/experiment="EXISTENCE:direct assay:GO:0030623 U5 snRNA
binding [PMID:31289129]"
/experiment="EXISTENCE:direct assay:GO:0032968 positive
regulation of transcription elongation by RNA polymerase
II [PMID:26945063]"
/experiment="EXISTENCE:direct assay:GO:0033553 rDNA
heterochromatin [PMID:16908835]"
/experiment="EXISTENCE:direct assay:GO:0042393 histone
binding [PMID:35102600]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:26945063]"
/experiment="EXISTENCE:direct assay:GO:0070990 snRNP
binding [PMID:31289129]"
/experiment="EXISTENCE:genetic interaction:GO:0090262
regulation of transcription-coupled nucleotide-excision
repair [PMID:20042611]"
/experiment="EXISTENCE:genetic interaction:GO:2001208
negative regulation of transcription elongation by RNA
polymerase I [PMID:21467039]"
/experiment="EXISTENCE:mutant phenotype:GO:0008298
intracellular mRNA localization [PMID:20713510]"
/experiment="EXISTENCE:mutant phenotype:GO:0032968
positive regulation of transcription elongation by RNA
polymerase II [PMID:19365074|PMID:26945063]"
/experiment="EXISTENCE:mutant phenotype:GO:0044877
protein-containing complex binding [PMID:26945063]"
/experiment="EXISTENCE:mutant phenotype:GO:2000232
regulation of rRNA processing [PMID:21949810]"
/experiment="EXISTENCE:mutant phenotype:GO:2001209
positive regulation of transcription elongation by RNA
polymerase I [PMID:21467039]"
/experiment="EXISTENCE:physical interaction:GO:0000993 RNA
polymerase II complex binding [PMID:9450930]"
/experiment="EXISTENCE:physical interaction:GO:0032044
DSIF complex [PMID:9450930]"
/note="Spt4p/5p (DSIF) transcription elongation factor
complex subunit; the Spt4/5 complex binds to ssRNA in a
sequence-specific manner, and in concert with RNAP I and
II has multiple roles regulating transcriptional
elongation, RNA processing, quality control, and
transcription-coupled repair; interacts with DNA upstream
of RNAPII and the non-template strand of the transcription
bubble; Spt5p is the only transcription elongation factor
conserved in all domains of life"
/codon_start=1
/product="transcription elongation factor SPT5"
/protein_id="NP_013703.1"
/db_xref="GeneID:854999"
/db_xref="SGD:S000004470"
/translation="MSDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSG
NVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQ
ATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDD
DEDDDDEAPTKRRRQERNRFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEA
SAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQR
FLLPSVDTATIWGVRCRPGKEKELIRKLLKKKFNLDRAMGKKKLKILSIFQRDNYTGR
IYIEAPKQSVIEKFCNGVPDIYISQKLLIPVQELPLLLKPNKSDDVALEEGSYVRIKR
GIYKGDLAMVDQISENNLEVMLKIVPRLDYGKFDEIDPTTQQRKSRRPTFAHRAPPQL
FNPTMALRLDQANLYKRDDRHFTYKNEDYIDGYLYKSFRIQHVETKNIQPTVEELARF
GSKEGAVDLTSVSQSIKKAQAAKVTFQPGDRIEVLNGEQRGSKGIVTRTTKDIATIKL
NGFTTPLEFPISTLRKIFEPGDHVTVINGEHQGDAGLVLMVEQGQVTFMSTQTSREVT
ITANNLSKSIDTTATSSEYALHDIVELSAKNVACIIQAGHDIFKVIDETGKVSTITKG
SILSKINTARARVSSVDANGNEIKIGDTIVEKVGSRREGQVLYIQTQQIFVVSKKIVE
NAGVFVVNPSNVEAVASKDNMLSNKMDLSKMNPEIISKMGPPSSKTFQQPIQSRGGRE
VALGKTVRIRSAGYKGQLGIVKDVNGDKATVELHSKNKHITIDKHKLTYYNREGGEGI
TYDELVNRRGRVPQARMGPSYVSAPRNMATGGIAAGAAATSSGLSGGMTPGWSSFDGG
KTPAVNAHGGSGGGGVSSWGGASTWGGQGNGGASAWGGAGGGASAWGGQGTGATSTWG
GASAWGNKSSWGGASTWASGGESNGAMSTWGGTGDRSAYGGASTWGGNNNNKSTRDGG
ASAWGNQDDGNRSAWNNQGNKSNYGGNSTWGGH"
gene complement(<251304..>251516)
/gene="MRPL39"
/locus_tag="YML009C"
/gene_synonym="bL33m"
/db_xref="GeneID:855002"
mRNA complement(<251304..>251516)
/gene="MRPL39"
/locus_tag="YML009C"
/gene_synonym="bL33m"
/product="mitochondrial 54S ribosomal protein YmL39"
/transcript_id="NM_001182364.1"
/db_xref="GeneID:855002"
CDS complement(251304..251516)
/gene="MRPL39"
/locus_tag="YML009C"
/gene_synonym="bL33m"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:2060626]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:2060626]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005762
mitochondrial large ribosomal subunit [PMID:2060626]"
/note="Mitochondrial ribosomal protein of the large
subunit"
/codon_start=1
/product="mitochondrial 54S ribosomal protein YmL39"
/protein_id="NP_013705.1"
/db_xref="GeneID:855002"
/db_xref="SGD:S000004468"
/translation="MVKVKSKNSVIKLLSTAASGYSRYISIKKGAPLVTQVRYDPVVK
RHVLFKEAKKRKVAERKPLDFLRTAK"
gene complement(<251839..>252990)
/gene="ERG6"
/locus_tag="YML008C"
/gene_synonym="ISE1; LIS1; SED6; VID1"
/db_xref="GeneID:855003"
mRNA complement(<251839..>252990)
/gene="ERG6"
/locus_tag="YML008C"
/gene_synonym="ISE1; LIS1; SED6; VID1"
/product="sterol 24-C-methyltransferase"
/transcript_id="NM_001182363.1"
/db_xref="GeneID:855003"
CDS complement(251839..252990)
/gene="ERG6"
/locus_tag="YML008C"
/gene_synonym="ISE1; LIS1; SED6; VID1"
/EC_number="2.1.1.41"
/experiment="EXISTENCE:direct assay:GO:0003838 sterol
24-C-methyltransferase activity
[PMID:18563465|PMID:6363386]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:6363386|PMID:11298754|PMID:9450962]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:10515935|PMID:24868093]"
/experiment="EXISTENCE:direct assay:GO:0006696 ergosterol
biosynthetic process [PMID:6363386]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process
[PMID:2677674|PMID:6363386]"
/note="Delta(24)-sterol C-methyltransferase; converts
zymosterol to fecosterol in the ergosterol biosynthetic
pathway by methylating position C-24; localized to lipid
particles, the plasma membrane-associated endoplasmic
reticulum, and the mitochondrial outer membrane"
/codon_start=1
/product="sterol 24-C-methyltransferase"
/protein_id="NP_013706.1"
/db_xref="GeneID:855003"
/db_xref="SGD:S000004467"
/translation="MSETELRKRQAQFTRELHGDDIGKKTGLSALMSKNNSAQKEAVQ
KYLRNWDGRTDKDAEERRLEDYNEATHSYYNVVTDFYEYGWGSSFHFSRFYKGESFAA
SIARHEHYLAYKAGIQRGDLVLDVGCGVGGPAREIARFTGCNVIGLNNNDYQIAKAKY
YAKKYNLSDQMDFVKGDFMKMDFEENTFDKVYAIEATCHAPKLEGVYSEIYKVLKPGG
TFAVYEWVMTDKYDENNPEHRKIAYEIELGDGIPKMFHVDVARKALKNCGFEVLVSED
LADNDDEIPWYYPLTGEWKYVQNLANLATFFRTSYLGRQFTTAMVTVMEKLGLAPEGS
KEVTAALENAAVGLVAGGKSKLFTPMMLFVARKPENAETPSQTSQEATQ"
gene complement(<253162..>253272)
/gene="MIN4"
/locus_tag="YML007C-A"
/db_xref="GeneID:855004"
mRNA complement(<253162..>253272)
/gene="MIN4"
/locus_tag="YML007C-A"
/product="Min4p"
/transcript_id="NM_001184487.1"
/db_xref="GeneID:855004"
CDS complement(253162..253272)
/gene="MIN4"
/locus_tag="YML007C-A"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095]"
/note="Mitochondrial hypothetical protein; green
fluorescent protein (GFP)-fusion protein localizes to
mitochondria"
/codon_start=1
/product="Min4p"
/protein_id="NP_076904.1"
/db_xref="GeneID:855004"
/db_xref="SGD:S000007621"
/translation="MVHFIFIALRSMRFMRRLVRNLQYLLLPITSSLLFI"
regulatory 253763..253783
/regulatory_class="other"
/note="Upstream open reading frame (uORF) in 5'
untranslated region of YAP1 gene, regulate translation"
gene <253848..>255800
/gene="YAP1"
/locus_tag="YML007W"
/gene_synonym="PAR1; PDR4; SNQ3"
/db_xref="GeneID:855005"
mRNA <253848..>255800
/gene="YAP1"
/locus_tag="YML007W"
/gene_synonym="PAR1; PDR4; SNQ3"
/product="DNA-binding transcription factor YAP1"
/transcript_id="NM_001182362.1"
/db_xref="GeneID:855005"
CDS 253848..255800
/gene="YAP1"
/locus_tag="YML007W"
/gene_synonym="PAR1; PDR4; SNQ3"
/experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding
transcription factor activity [PMID:11056165]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276|PMID:12582119|PMID:22842922|PMID:24034606|P
MID:27838435|PMID:9130715]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:12582119|PMID:22842922|PMID:24034606|P
MID:9130715]"
/experiment="EXISTENCE:direct assay:GO:0006357 regulation
of transcription by RNA polymerase II [PMID:11056165]"
/experiment="EXISTENCE:mutant phenotype:GO:0000304
response to singlet oxygen [PMID:16862604]"
/experiment="EXISTENCE:mutant phenotype:GO:0009408
response to heat [PMID:10809786]"
/experiment="EXISTENCE:mutant phenotype:GO:0061395
positive regulation of transcription from RNA polymerase
II promoter in response to arsenic-containing substance
[PMID:15575969]"
/experiment="EXISTENCE:mutant phenotype:GO:1900101
regulation of endoplasmic reticulum unfolded protein
response [PMID:27373166]"
/note="Basic leucine zipper (bZIP) transcription factor;
required for oxidative stress tolerance; activated by H2O2
through the multistep formation of disulfide bonds and
transit from the cytoplasm to the nucleus; Yap1p is
degraded in the nucleus after the oxidative stress has
passed; mediates resistance to cadmium; relative
distribution to the nucleus increases upon DNA replication
stress; YAP1 has a paralog, CAD1, that arose from the
whole genome duplication"
/codon_start=1
/product="DNA-binding transcription factor YAP1"
/protein_id="NP_013707.1"
/db_xref="GeneID:855005"
/db_xref="SGD:S000004466"
/translation="MSVSTAKRSLDVVSPGSLAEFEGSKSRHDEIENEHRRTGTRDGE
DSEQPKKKGSKTSKKQDLDPETKQKRTAQNRAAQRAFRERKERKMKELEKKVQSLESI
QQQNEVEATFLRDQLITLVNELKKYRPETRNDSKVLEYLARRDPNLHFSKNNVNHSNS
EPIDTPNDDIQENVKQKMNFTFQYPLDNDNDNDNSKNVGKQLPSPNDPSHSAPMPINQ
TQKKLSDATDSSSATLDSLSNSNDVLNNTPNSSTSMDWLDNVIYTNRFVSGDDGSNSK
TKNLDSNMFSNDFNFENQFDEQVSEFCSKMNQVCGTRQCPIPKKPISALDKEVFASSS
ILSSNSPALTNTWESHSNITDNTPANVIATDATKYENSFSGFGRLGFDMSANHYVVND
NSTGSTDSTGSTGNKNKKNNNNSDDVLPFISESPFDMNQVTNFFSPGSTGIGNNAASN
TNPSLLQSSKEDIPFINANLAFPDDNSTNIQLQPFSESQSQNKFDYDMFFRDSSKEGN
NLFGEFLEDDDDDKKAANMSDDESSLIKNQLINEEPELPKQYLQSVPGNESEISQKNG
SSLQNADKINNGNDNDNDNDVVPSKEGSLLRCSEIWDRITTHPKYSDIDVDGLCSELM
AKAKCSERGVVINAEDVQLALNKHMN"
gene complement(<256092..>258416)
/gene="GIS4"
/locus_tag="YML006C"
/db_xref="GeneID:855006"
mRNA complement(<256092..>258416)
/gene="GIS4"
/locus_tag="YML006C"
/product="Gis4p"
/transcript_id="NM_001182361.1"
/db_xref="GeneID:855006"
CDS complement(256092..258416)
/gene="GIS4"
/locus_tag="YML006C"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:17030993]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0035556
intracellular signal transduction [PMID:10628841]"
/experiment="EXISTENCE:mutant phenotype:GO:0006873
intracellular monoatomic ion homeostasis [PMID:17030993]"
/note="CAAX box containing hypothetical protein; proposed
to be involved in the RAS/cAMP signaling pathway"
/codon_start=1
/product="Gis4p"
/protein_id="NP_013708.1"
/db_xref="GeneID:855006"
/db_xref="SGD:S000004465"
/translation="MQKSVRVGDYFDNDDNGLWSWYLTNLRLGDFEELIGNQLKYTLL
KRFLNSHFYGDNNISARPNKKILLVSIPENVHEDISILEIFLKDYFHLEKLEHIQISK
LTHSHCYNHENHYLLTDNLNNFQDPTFLEFASTSWQVQKNSKALNNNNRNSIPPPTIS
SSKASNGKLESNVSDDQWSNINTQTSTATRTNTNTRTLTSPDTVDINVTSVNSQSNNN
DTPQDNENEVDEEDATSSIVLNFSHSRTVDSKPNRLPKIFPSYTNEDYTPSHSEIMSI
DSFAGEDVSSTYPGQDLSLTTARREDESGQDEVEDHYSRVSHDLGDESIDQASYSMES
SVSYTSYSSSSNSSSAHYSLSSSSRGNPKRENIDHTNATYVSELSSITSSIDNLTTST
TPEEEDNLIHHNYDAQGYGSGEDDGEEVYDDEDLSSSDYSVLSILPSISICDSLGYFR
LVLQSILIQDPDTKEIFTAIRQSNNKPTMASVTDDWLLYDSNFSMNNLQILTLQDLLD
IKRSFPKILFYTMVIVTNSGKQVEEEFKNPNYDNREGISKEQPLDSELSLTNDPQQYF
PTAYNNGYNDYIDDEDDEDDGDDASLSEQSGPQMYIPTRMESNVTTAHRSIRTVNSIG
EWAFNRHNSVTKIDKSNSNELDNSKTGESTVLSSEPHPMTQLSNSNTTSSNFSHSLKT
KNSHKPNSKGNNESNSKNELKKIKSSINAMSAVERSKSLPLPTLLKSLSGIDNPTHAT
NKDRKRWKFQMNRFKNHKNSGSAGTDKSQRCAIM"
gene complement(259158..259239)
/locus_tag="YNCM0009C"
/db_xref="GeneID:855007"
tRNA complement(259158..259239)
/locus_tag="YNCM0009C"
/product="tRNA-Ser"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0030371 translation
repressor activity [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043555 regulation
of translation in response to stress [PMID:27609601]"
/note="Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:855007"
/db_xref="SGD:S000006729"
gene <260221..>261609
/gene="TRM12"
/locus_tag="YML005W"
/gene_synonym="TYW2"
/db_xref="GeneID:855008"
mRNA <260221..>261609
/gene="TRM12"
/locus_tag="YML005W"
/gene_synonym="TYW2"
/product="tRNA(Phe) (4-demethylwyosine(37)-C(7))
aminocarboxypropyltransferase"
/transcript_id="NM_001182360.1"
/db_xref="GeneID:855008"
CDS 260221..261609
/gene="TRM12"
/locus_tag="YML005W"
/gene_synonym="TYW2"
/EC_number="2.5.1.114"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0008757
S-adenosylmethionine-dependent methyltransferase activity
[PMID:16005430]"
/experiment="EXISTENCE:direct assay:GO:0016765 transferase
activity, transferring alkyl or aryl (other than methyl)
groups [PMID:16642040]"
/experiment="EXISTENCE:direct assay:GO:0030488 tRNA
methylation [PMID:16005430]"
/experiment="EXISTENCE:mutant phenotype:GO:0031591
wybutosine biosynthetic process
[PMID:16642040|PMID:17150819]"
/note="S-adenosylmethionine-dependent methyltransferase;
required for wybutosine formation in
phenylalanine-accepting tRNA; member of the seven
beta-strand family"
/codon_start=1
/product="tRNA(Phe) (4-demethylwyosine(37)-C(7))
aminocarboxypropyltransferase"
/protein_id="NP_013709.1"
/db_xref="GeneID:855008"
/db_xref="SGD:S000004464"
/translation="MSDETMPVEFLVSDKRLLKTIKVKLETNGLFVTPIYSDNDNKVI
KSSIEDLNHPLAVEINNIAGVKARFHESGNLERSEGHLKHQSNSITEFTKSFLKDHGL
ANDKIFLSHLLDHLPLKYTIYPPVVLFNNSTVRSFNHPIWQKAFQLKLFDPNEYYREL
LCFLSPGKPSKGTSLHPNNRLLTHLAINNPITEADVLRRPFNIQPLYGKLIDDSILDD
NDNTLWENPSQEQLNSSIWCKVIQNGVTQIWSPVFTMFSRGNIKEKKRVLTTFPDICN
NDVVDLYAGIGYFTFSYLTKGARTLFAFELNPWSVEGLKRGLKANGFNKSGNCHVFQE
SNEMCVQRLTEFLSQNPGFRLRIRHINLGLLPSSKQGWPLAIKLIYLQGASLEKVTMH
IHENVHIDAIEDGSFEKNVIVELDAINESIALIRNRGIKLQFVRSKLERIKTFAPDIW
HVCVDVDVIVST"
gene complement(<261705..>262685)
/gene="GLO1"
/locus_tag="YML004C"
/db_xref="GeneID:855009"
mRNA complement(<261705..>262685)
/gene="GLO1"
/locus_tag="YML004C"
/product="lactoylglutathione lyase GLO1"
/transcript_id="NM_001182359.1"
/db_xref="GeneID:855009"
CDS complement(261705..262685)
/gene="GLO1"
/locus_tag="YML004C"
/EC_number="4.4.1.5"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0019243
methylglyoxal catabolic process to D-lactate via
S-lactoyl-glutathione [PMID:8824231]"
/experiment="EXISTENCE:mutant phenotype:GO:0004462
lactoylglutathione lyase activity [PMID:8824231]"
/experiment="EXISTENCE:mutant phenotype:GO:0006749
glutathione metabolic process [PMID:8824231]"
/note="Monomeric glyoxalase I; catalyzes the
detoxification of methylglyoxal (a by-product of
glycolysis) via condensation with glutathione to produce
S-D-lactoylglutathione; required for full activity of
O-acetyl homoserine sulfhydrylase, Met17p; expression
regulated by methylglyoxal levels and osmotic stress"
/codon_start=1
/product="lactoylglutathione lyase GLO1"
/protein_id="NP_013710.1"
/db_xref="GeneID:855009"
/db_xref="SGD:S000004463"
/translation="MSTDSTRYPIQIEKASNDPTLLLNHTCLRVKDPARTVKFYTEHF
GMKLLSRKDFEEAKFSLYFLSFPKDDIPKNKNGEPDVFSAHGVLELTHNWGTEKNPDY
KINNGNEEPHRGFGHICFSVSDINKTCEELESQGVKFKKRLSEGRQKDIAFALGPDGY
WIELITYSREGQEYPKGSVGNKFNHTMIRIKNPTRSLEFYQNVLGMKLLRTSEHESAK
FTLYFLGYGVPKTDSVFSCESVLELTHNWGTENDPNFHYHNGNSEPQGYGHICISCDD
AGALCKEIEVKYGDKIQWSPKFNQGRMKNIAFLKDPDGYSIEVVPHGLIA"
rep_origin 263063..263296
/note="ARS1309; Autonomously Replicating Sequence"
/db_xref="SGD:S000118369"
gene <263483..>264355
/locus_tag="YML003W"
/gene_synonym="VRL1"
/db_xref="GeneID:855010"
mRNA <263483..>264355
/locus_tag="YML003W"
/gene_synonym="VRL1"
/product="uncharacterized protein"
/transcript_id="NM_001182358.1"
/db_xref="GeneID:855010"
CDS 263483..264355
/locus_tag="YML003W"
/gene_synonym="VRL1"
/note="Truncated 5' end of YML002W; in many strains,
YML002W is continuous with YML003W, and is predicted to
encode a single protein of 1090 aa with a full-length VPS9
domain; in strains S288C, W303, and CEN.PK, a single
thymine residue is deleted near the 3' end of YML003W at
ChrXIII:264337, causing a frameshift and premature stop
codon, truncating YML003W"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013711.1"
/db_xref="GeneID:855010"
/db_xref="SGD:S000004462"
/translation="MSVYHLPTLLNPLVNAIFNCPEPERSPLKKLFANLKTRRFILLA
PPSEYLLNYHDVKSKLPLHDLCYNAEFINSYILLMTENSYINTNSRDSHYETLDGKTV
VIQWKNNVIHALNGFHIRRRLKILETKILPNFNDYFEGAADFIILFIDQPLNCEFVPN
DYLQCFHNYEKIPKNAHAMPNLSIDSFQQERSSFENILHIHPARLTQLGQLFSSYRTL
APGDDPSRSIFESIVQQAFDGMKSDSLFKNFSNLYDLIHDYFELNLYDDIWSRLTTHF
KGHEVDTEKINIFQ"
gene <264541..>266754
/gene="VRL1"
/locus_tag="YML002W"
/db_xref="GeneID:855011"
mRNA <264541..>266754
/gene="VRL1"
/locus_tag="YML002W"
/product="Vrl1p"
/transcript_id="NM_001182357.1"
/db_xref="GeneID:855011"
CDS 264541..266754
/gene="VRL1"
/locus_tag="YML002W"
/note="hypothetical protein; expression induced by heat
and by calcium shortage; in many strains, YML002W is
continuous with YML003W, and is predicted to encode a
single protein of 1090 aa with a full-length VPS9 domain;
in strains S288C, W303, and CEN.PK, a single thymine
residue is deleted near the 3' end of YML003W at
ChrXIII:264337, causing a frameshift and premature stop
codon, truncating YML003W"
/codon_start=1
/product="Vrl1p"
/protein_id="NP_013712.1"
/db_xref="GeneID:855011"
/db_xref="SGD:S000004461"
/translation="MDSHQLELPDGLNNMTMDADTLISLFVLVVCRSEQKHLKSHLYY
LQNFSNNSSSTKFGILGYAVSTLEAVVCYFEDFNKNTGNVAKANTLCEKTKNLLDKLS
CENPTNEVEDLATYKDILTYRNEQGQSILSICITNHKNYILLDILSEYENDFPVEDLL
EDETIDGSTLLIESIKAGNLEAAKVLIKIMLFNCTEEELVSYINKTDKYARTVAHYLT
HEMDILKSIGNYIDWKRKNSSGQTPLFSIFRSYDQPNYEEMVKTAFDIANTWYRKHNS
LFDYLDHTDNKGNSLLHVLKTNIPILLQLTKLDINEENYKGLTPLMVYVKYKRLSNID
AITKDRRLILEKVQNSTFFTCFDYAKDHSVLSKIGERGVKDSLFGLIYFHSLRYHNLN
ATTNITSVSNAEKPFATTVINMKTIQGLLRSILKDNPFTFLPLNTYIDEISHLNRSDL
TIIGKTDVTSLLHQLTNCFNVLLFLKKIPENLFTDEASILYWMRINTSKRNQKPSGKE
NPKTMEPEEINMIQSFLRFNFDEISSFKASLNILRKVLIFINLKSDDFEDAYKGLNEM
GRKLINSEASSAFKGIITNHNMFSELSLAALLENVRFLEQCTIQLSSFVQIILFEKIP
NWWKHYGEFLALHKSYRKAFPNMVKPKSASDTSSRAPLGGFIETKREQSEQRLAVQIK
ASSKMLKELGSEIFVAHERLAEELSNYMEFRKACLDQRSLVAFATTNISVLQECV"
gene <267174..>267800
/gene="YPT7"
/locus_tag="YML001W"
/gene_synonym="AST4; VAM4"
/db_xref="GeneID:855012"
mRNA <267174..>267800
/gene="YPT7"
/locus_tag="YML001W"
/gene_synonym="AST4; VAM4"
/product="Rab family GTPase YPT7"
/transcript_id="NM_001182356.1"
/db_xref="GeneID:855012"
CDS 267174..267800
/gene="YPT7"
/locus_tag="YML001W"
/gene_synonym="AST4; VAM4"
/experiment="EXISTENCE:direct assay:GO:0000011 vacuole
inheritance [PMID:7489715]"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:11853670]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:22593205|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0003924 GTPase
activity [PMID:11210571]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0016192
vesicle-mediated transport [PMID:9015302]"
/experiment="EXISTENCE:direct assay:GO:0043254 regulation
of protein-containing complex assembly [PMID:32160129]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:22593205]"
/experiment="EXISTENCE:direct assay:GO:1990816
vacuole-mitochondrion membrane contact site
[PMID:25026035]"
/experiment="EXISTENCE:mutant phenotype:GO:0006897
endocytosis [PMID:1473149]"
/experiment="EXISTENCE:mutant phenotype:GO:0016236
macroautophagy [PMID:19793921]"
/experiment="EXISTENCE:mutant phenotype:GO:0032258
cytoplasm to vacuole transport by the Cvt pathway
[PMID:19793921]"
/experiment="EXISTENCE:mutant phenotype:GO:0032889
regulation of vacuole fusion, non-autophagic
[PMID:11598008|PMID:7489715]"
/experiment="EXISTENCE:mutant phenotype:GO:0034727
piecemeal microautophagy of the nucleus [PMID:18701704]"
/experiment="EXISTENCE:mutant phenotype:GO:0072665 protein
localization to vacuole [PMID:22593205]"
/experiment="EXISTENCE:physical interaction:GO:0005515
protein binding
[PMID:11062257|PMID:18809726|PMID:20604902|PMID:21325627]"
/experiment="EXISTENCE:physical interaction:GO:0042147
retrograde transport, endosome to Golgi [PMID:22593205]"
/note="Rab family GTPase; GTP-binding protein of the rab
family; required for homotypic fusion event in vacuole
inheritance, for endosome-endosome fusion; localizes to
sites of contact between the vacuole and mitochondria
(vCLAMPs); interacts with the cargo selection/retromer
complex for retrograde sorting; similar to mammalian Rab7"
/codon_start=1
/product="Rab family GTPase YPT7"
/protein_id="NP_013713.1"
/db_xref="GeneID:855012"
/db_xref="SGD:S000004460"
/translation="MSSRKKNILKVIILGDSGVGKTSLMHRYVNDKYSQQYKATIGAD
FLTKEVTVDGDKVATMQVWDTAGQERFQSLGVAFYRGADCCVLVYDVTNASSFENIKS
WRDEFLVHANVNSPETFPFVILGNKIDAEESKKIVSEKSAQELAKSLGDIPLFLTSAK
NAINVDTAFEEIARSALQQNQADTEAFEDDYNDAINIRLDGENNSCSC"
centromere 268031..268149
/note="CEN13; Chromosome XIII centromere"
/db_xref="SGD:S000006474"
centromere 268031..268040
/note="CEN13_CDEI of CEN13"
centromere 268041..268124
/note="CEN13_CDEII of CEN13"
centromere 268125..268149
/note="CEN13_CDEIII of CEN13"
gene complement(<269019..>271136)
/gene="CDC5"
/locus_tag="YMR001C"
/gene_synonym="MSD2; PKX2"
/db_xref="GeneID:855013"
mRNA complement(<269019..>271136)
/gene="CDC5"
/locus_tag="YMR001C"
/gene_synonym="MSD2; PKX2"
/product="polo kinase CDC5"
/transcript_id="NM_001182497.1"
/db_xref="GeneID:855013"
CDS complement(269019..271136)
/gene="CDC5"
/locus_tag="YMR001C"
/gene_synonym="MSD2; PKX2"
/EC_number="2.7.11.21"
/experiment="EXISTENCE:direct assay:GO:0000922 spindle
pole [PMID:10594031]"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity
[PMID:12637549|PMID:17122856|PMID:8321244|PMID:16319894]"
/experiment="EXISTENCE:direct assay:GO:0004674 protein
serine/threonine kinase activity [PMID:21498574]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9819423]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:10594031]"
/experiment="EXISTENCE:direct assay:GO:0019237 centromeric
DNA binding [PMID:27226485]"
/experiment="EXISTENCE:direct assay:GO:0044732 mitotic
spindle pole body [PMID:32553169]"
/experiment="EXISTENCE:direct assay:GO:0051219
phosphoprotein binding [PMID:27325700]"
/experiment="EXISTENCE:genetic interaction:GO:0010458 exit
from mitosis [PMID:21937712]"
/experiment="EXISTENCE:genetic interaction:GO:0010696
positive regulation of mitotic spindle pole body
separation [PMID:18500339]"
/experiment="EXISTENCE:genetic interaction:GO:0070194
synaptonemal complex disassembly [PMID:18832066]"
/experiment="EXISTENCE:genetic interaction:GO:1902542
regulation of protein localization to mitotic spindle pole
body [PMID:21937712]"
/experiment="EXISTENCE:genetic interaction:GO:1904750
negative regulation of protein localization to nucleolus
[PMID:14551257]"
/experiment="EXISTENCE:mutant phenotype:GO:0000712
resolution of meiotic recombination intermediates
[PMID:12717442]"
/experiment="EXISTENCE:mutant phenotype:GO:0004672 protein
kinase activity [PMID:17122856|PMID:8321244]"
/experiment="EXISTENCE:mutant phenotype:GO:0010696
positive regulation of mitotic spindle pole body
separation [PMID:18500339]"
/experiment="EXISTENCE:mutant phenotype:GO:0035025
positive regulation of Rho protein signal transduction
[PMID:16763112]"
/experiment="EXISTENCE:mutant phenotype:GO:0090306 meiotic
spindle assembly [PMID:20237423|PMID:24386320]"
/experiment="EXISTENCE:mutant phenotype:GO:0110083
positive regulation of protein localization to cell
division site involved in mitotic actomyosin contractile
ring assembly [PMID:16763112]"
/experiment="EXISTENCE:mutant phenotype:GO:1903353
regulation of nucleus organization [PMID:25454593]"
/experiment="EXISTENCE:mutant phenotype:GO:1904749
regulation of protein localization to nucleolus
[PMID:33481703]"
/experiment="EXISTENCE:mutant phenotype:GO:1904750
negative regulation of protein localization to nucleolus
[PMID:14551257]"
/experiment="EXISTENCE:physical interaction:GO:0044877
protein-containing complex binding
[PMID:27226485|PMID:27325700]"
/note="Polo-like kinase required for mitotic exit;
regulates mitotic spindle assembly, nuclear shape, and
protein localization to the nucleolus and SPBs; controls
targeting and activation of Rho1p at the division site via
Rho1p-GEFs; role in adaptation to DNA damage promotes
genome instability during replicative senescence;
regulates meiotic commitment, spindle assembly, chiasmata
formation, recombination intermediate resolution and SC
disassembly; human homologs PLK1 and PLK3 complement cdc5
mutants"
/codon_start=1
/product="polo kinase CDC5"
/protein_id="NP_013714.1"
/db_xref="GeneID:855013"
/db_xref="SGD:S000004603"
/translation="MSLGPLKAINDKQLNTRSKLVHTPIKGNTADLVGKENHFKQTKR
LDPNNDHHHQPAQKKKREKLSALCKTPPSLIKTRGKDYHRGHFLGEGGFARCFQIKDD
SGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEI
CPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNL
KIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLI
GKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDY
VWFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQKRD
YISSIKSSIDKLEEYHQNRPFLPHSLSPGGTKQKYKEVVDIEAQRRLNDLAREARIRR
AQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLPKSRLPKI
KHPMIVTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTVLRLADAEEFWYISYDDREGWV
ASHYLLSEKPRELSRHLEVVDFFAKYMKANLSRVSTFGREEYHKDDVFLRRYTRYKPF
VMFELSDGTFQFNFKDHHKMAISDGGKLVTYISPSHESTTYPLVEVLKYGEIPGYPES
NFREKLTLIKEGLKQKSTIVTVD"
gene complement(<271347..>271577)
/locus_tag="YMR001C-A"
/db_xref="GeneID:1466498"
mRNA complement(<271347..>271577)
/locus_tag="YMR001C-A"
/product="uncharacterized protein"
/transcript_id="NM_001184613.1"
/db_xref="GeneID:1466498"
CDS complement(271347..271577)
/locus_tag="YMR001C-A"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878140.1"
/db_xref="GeneID:1466498"
/db_xref="SGD:S000028691"
/translation="MIFECTSFETRHILNSYSCATQLSYNTYRITEKVNPIQAAVSKN
NKPFVSNSDSAFFPIFSSFNFVAYTTLTFKKT"
gene <272193..>272663
/gene="MIX17"
/locus_tag="YMR002W"
/gene_synonym="MIC17"
/db_xref="GeneID:855014"
mRNA <272193..>272663
/gene="MIX17"
/locus_tag="YMR002W"
/gene_synonym="MIC17"
/product="Mix17p"
/transcript_id="NM_001182498.1"
/db_xref="GeneID:855014"
CDS 272193..272663
/gene="MIX17"
/locus_tag="YMR002W"
/gene_synonym="MIC17"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005758
mitochondrial intermembrane space [PMID:17095012]"
/experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
respiration [PMID:19703468]"
/note="Mitochondrial intermembrane space protein; required
for normal oxygen consumption; contains twin
cysteine-x9-cysteine motifs; protein abundance increases
in response to DNA replication stress"
/codon_start=1
/product="Mix17p"
/protein_id="NP_013715.1"
/db_xref="GeneID:855014"
/db_xref="SGD:S000004604"
/translation="MARSRGSSRPISRSRPTQTRSASTMAAPVHPQQQQQPNAYSHPP
AAGAQTRQPGMFAQMASTAAGVAVGSTIGHTLGAGITGMFSGSGSDSAPVEQQQQNMA
NTSGQTQTDQQLGRTCEIDARNFTRCLDENNGNFQICDYYLQQLKACQEAARQY"
gene <273118..>273714
/gene="AIM34"
/locus_tag="YMR003W"
/db_xref="GeneID:855015"
mRNA <273118..>273714
/gene="AIM34"
/locus_tag="YMR003W"
/product="Aim34p"
/transcript_id="NM_001182499.1"
/db_xref="GeneID:855015"
CDS 273118..273714
/gene="AIM34"
/locus_tag="YMR003W"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095]"
/note="hypothetical protein; GFP-fusion protein localizes
to the mitochondria; null mutant is viable and displays
reduced frequency of mitochondrial genome loss"
/codon_start=1
/product="Aim34p"
/protein_id="NP_013716.1"
/db_xref="GeneID:855015"
/db_xref="SGD:S000004605"
/translation="MSISLLGRIVSQQFSGIRAAEPGRSLYLPFTLLLKQPGAYKVSL
HRYVHSTQTKSHLSFLMNNNDITPFQKFTVKVLKEQCKSRGLKLSGRKSDLLQRLITH
DSCSNKKSSVKINEPKKKRILINDPIKITKKLVSDKTFRTIEKNISSLQNTPVIETPC
DVHSHLQPRDRIFLLGFFMLSCLWWNLEPQESKPTIDH"
gene <274017..>275552
/gene="MVP1"
/locus_tag="YMR004W"
/db_xref="GeneID:855016"
mRNA <274017..>275552
/gene="MVP1"
/locus_tag="YMR004W"
/product="Mvp1p"
/transcript_id="NM_001182500.1"
/db_xref="GeneID:855016"
CDS 274017..275552
/gene="MVP1"
/locus_tag="YMR004W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:21954159]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:7862158]"
/experiment="EXISTENCE:direct assay:GO:0005768 endosome
[PMID:24567361]"
/experiment="EXISTENCE:direct assay:GO:0032266
phosphatidylinositol-3-phosphate binding [PMID:11557775]"
/experiment="EXISTENCE:direct assay:GO:0097320 plasma
membrane tubulation [PMID:24567361]"
/experiment="EXISTENCE:mutant phenotype:GO:0006623 protein
targeting to vacuole [PMID:7862158]"
/experiment="EXISTENCE:mutant phenotype:GO:0042147
retrograde transport, endosome to Golgi [PMID:24567361]"
/note="Protein required for sorting proteins to the
vacuole; Mvp1p and Vps1p act in concert to promote
membrane traffic to the vacuole; participates in
transcription initiation and/or early elongation of
specific genes; interacts with 'foot domain' of RNA
polymerase II; deletion results in abnormal CTD-Ser5
phosphorylation of RNA polymerase II at specific promoter
regions; protein abundance increases in response to DNA
replication stress"
/codon_start=1
/product="Mvp1p"
/protein_id="NP_013717.1"
/db_xref="GeneID:855016"
/db_xref="SGD:S000004606"
/translation="MDNYEGSDPWNTSSNAWTKDDDHVVSTTNSEPSLNGISGEFNTL
NFSTPLDTNEEDTGFLPTNDVLEESIWDDSRNPLGATGMSQTPNIAANETVIDKNDAR
DQNIEESEADLLDWTNNVRKTYRPLDADIIIIEEIPEREGLLFKHANYLVKHLIALPS
TSPSEERTVVRRYSDFLWLREILLKRYPFRMIPELPPKRIGSQNADQLFLKKRRIGLS
RFINLVMKHPKLSNDDLVLTFLTVRTDLTSWRKQATYDTSNEFADKKISQEFMKMWKK
EFAEQWNQAASCIDTSMELWYRITLLLERHEKRIMQMVHERNFFETLVDNFSEVTPKL
YPVQQNDTILDINNNLSIIKKHLETTSSICKQETEEISGTLSPKFKIFTDILLSLRSL
FERYKIMAANNVVELQRHVELNKEKLESMKGKPDVSGAEYDRIKKIIQKDRRSIIEQS
NRAWLIRQCILEEFTIFQETQFLITRAFQDWAKLNSNHAGLKLNEWEKLVTSIMDMPI
SRE"
gene <276045..>277211
/gene="TAF4"
/locus_tag="YMR005W"
/gene_synonym="MPT1; TAF48; TSG2"
/db_xref="GeneID:855017"
mRNA <276045..>277211
/gene="TAF4"
/locus_tag="YMR005W"
/gene_synonym="MPT1; TAF48; TSG2"
/product="Taf4p"
/transcript_id="NM_001182501.1"
/db_xref="GeneID:855017"
CDS 276045..277211
/gene="TAF4"
/locus_tag="YMR005W"
/gene_synonym="MPT1; TAF48; TSG2"
/experiment="EXISTENCE:direct assay:GO:0003682 chromatin
binding [PMID:12600943]"
/experiment="EXISTENCE:direct assay:GO:0005669
transcription factor TFIID complex
[PMID:10788514|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0006366
transcription by RNA polymerase II
[PMID:12138208|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:12501245]"
/experiment="EXISTENCE:physical interaction:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:12501245]"
/note="TFIID subunit (48 kDa); involved in RNA polymerase
II transcription initiation; potential Cdc28p substrate"
/codon_start=1
/product="Taf4p"
/protein_id="NP_013718.1"
/db_xref="GeneID:855017"
/db_xref="SGD:S000004607"
/translation="MANSPKKPSDGTGVSASDTPKYQHTVPETKPAFNLSPGKASELS
HSLPSPSQIKSTAHVSSTHNDAAGNTDDSVLPKNVSPTTNLRVESNGDTNNMFSSPAG
LALPKKDDKKKNKGTSKADSKDGKASNSSGQNAQQQSDPNKMQDVLFSAGIDVREEEA
LLNSSINASKSQVQTNNVKIPNHLPFLHPEQVSNYMRKVGKEQNFNLTPTKNPEILDM
MSSACENYMRDILTNAIVISRHRRKAVKINSGRRSEVSAALRAIALIQKKEEERRVKK
RIALGLEKEDYENKIDSEETLHRASNVTAGLRAGSKKQYGWLTSSVNKPTSLGAKSSG
KVASDITARGESGLKFREAREEPGIVMRDLLFALENRRNSVQTIISKGYAKIRD"
gene complement(<277561..>279681)
/gene="PLB2"
/locus_tag="YMR006C"
/db_xref="GeneID:855018"
mRNA complement(<277561..>279681)
/gene="PLB2"
/locus_tag="YMR006C"
/product="lysophospholipase"
/transcript_id="NM_001182502.1"
/db_xref="GeneID:855018"
CDS complement(277561..279681)
/gene="PLB2"
/locus_tag="YMR006C"
/EC_number="3.1.1.5"
/experiment="EXISTENCE:direct assay:GO:0004622
lysophospholipase activity [PMID:10497163]"
/experiment="EXISTENCE:direct assay:GO:0005576
extracellular region [PMID:10497163]"
/experiment="EXISTENCE:direct assay:GO:0006650
glycerophospholipid metabolic process [PMID:10497163]"
/experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
cell wall [PMID:10383953|PMID:15781460]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0004622
lysophospholipase activity [PMID:10497163]"
/experiment="EXISTENCE:mutant phenotype:GO:0006650
glycerophospholipid metabolic process [PMID:10497163]"
/note="Phospholipase B (lysophospholipase) involved in
lipid metabolism; displays transacylase activity in vitro;
overproduction confers resistance to
lysophosphatidylcholine"
/codon_start=1
/product="lysophospholipase"
/protein_id="NP_013719.1"
/db_xref="GeneID:855018"
/db_xref="SGD:S000004608"
/translation="MQLRNILQASSLISGLSLAADSSSTTGDGYAPSIIPCPSDDTSL
VRNASGLSTAETDWLKKRDAYTKEALHSFLSRATSNFSDTSLLSTLFSSNSSNVPKIG
IACSGGGYRAMLGGAGMIAAMDNRTDGANEHGLGGLLQSSTYLSGLSGGNWLTGTLAW
NNWTSVQEIVDHMSESDSIWNITKSIVNPGGSNLTYTIERWESIVQEVQAKSDAGFNI
SLSDLWARALSYNFFPSLPDAGSALTWSSLRDVDVFKNGEMPLPITVADGRYPGTTVI
NLNATLFEFTPFEMGSWDPSLNAFTDVKYLGTNVTNGKPVNKDQCVSGYDNAGFVIAT
SASLFNEFSLEASTSTYYKMINSFANKYVNNLSQDDDDIAIYAANPFKDTEFVDRNYT
SSIVDADDLFLVDGGEDGQNLPLVPLIKKERDLDVVFALDISDNTDESWPSGVCMTNT
YERQYSKQGKGMAFPYVPDVNTFLNLGLTNKPTFFGCDAKNLTDLEYIPPLVVYIPNT
KHSFNGNQSTLKMNYNVTERLGMIRNGFEAATMGNFTDDSNFLGCIGCAIIRRKQESL
NATLPPECTKCFADYCWNGTLSTSANPELSGNSTYQSGAIASAISEATDGIPITALLG
SSTSGNTTSNSTTSTSSNVTSNSNSSSNTTLNSNSSSSSISSSTARSSSSTANKANAA
AISYANTNTLMSLLGAITALFGLI"
gene <279960..>280340
/locus_tag="YMR007W"
/db_xref="GeneID:855019"
mRNA <279960..>280340
/locus_tag="YMR007W"
/product="uncharacterized protein"
/transcript_id="NM_001348864.1"
/db_xref="GeneID:855019"
CDS 279960..280340
/locus_tag="YMR007W"
/note="hypothetical protein; conserved among S. cerevisiae
strains; YMR007W is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335804.1"
/db_xref="GeneID:855019"
/db_xref="SGD:S000004609"
/translation="MRKKCPQGKKLLKKATRPFVGAFRRRIRAKKNLISQFGQTGCIG
CDGKFSIGITIEKYVLNLVVRIIIVFALCRITELSVFDSSLRCKSRKTRLSKAARKKE
TDHFHEQCRYVEVKFGLQMAYLQS"
gene complement(<280590..>282584)
/gene="PLB1"
/locus_tag="YMR008C"
/db_xref="GeneID:855020"
mRNA complement(<280590..>282584)
/gene="PLB1"
/locus_tag="YMR008C"
/product="lysophospholipase"
/transcript_id="NM_001182504.1"
/db_xref="GeneID:855020"
CDS complement(280590..282584)
/gene="PLB1"
/locus_tag="YMR008C"
/EC_number="3.1.1.5"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:25258318]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836|PMID:8051052]"
/experiment="EXISTENCE:direct assay:GO:0042597 periplasmic
space [PMID:8051052]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0004622
lysophospholipase activity [PMID:8051052]"
/experiment="EXISTENCE:mutant phenotype:GO:0006650
glycerophospholipid metabolic process [PMID:8051052]"
/experiment="EXISTENCE:mutant phenotype:GO:0036151
phosphatidylcholine acyl-chain remodeling [PMID:23501167]"
/note="Phospholipase B (lysophospholipase) involved in
lipid metabolism; required for efficient acyl chain
remodeling of newly synthesized
phosphatidylethanolamine-derived phosphatidylcholine;
required for deacylation of phosphatidylcholine and
phosphatidylethanolamine but not phosphatidylinositol;
PLB1 has a paralog, PLB3, that arose from the whole genome
duplication"
/codon_start=1
/product="lysophospholipase"
/protein_id="NP_013721.1"
/db_xref="GeneID:855020"
/db_xref="SGD:S000004610"
/translation="MKLQSLLVSAAVLTSLTENVNAWSPNNSYVPANVTCDDDINLVR
EASGLSDNETEWLKKRDAYTKEALHSFLNRATSNFSDTSLLSTLFGSNSSNMPKIAVA
CSGGGYRAMLSGAGMLAAMDNRTDGANEHGLGGLLQGATYLAGLSGGNWLTSTLAWNN
WTSVQAIVDNTTESNSIWDISHSILTPDGINIFKTGSRWDDISDDVQDKKDAGFNISL
ADVWGRALAYNFWPSLHRGGVGYTWSTLREADVFKNGEMPFPITVADGRYPGTTVINL
NATLFEFNPFEMGSWDPTLNAFTDVKYLGTNVTNGKPVNKGQCIAGFDNTGFITATSS
TLFNQFLLRLNSTDLPSFIANLATDFLEDLSDNSDDIAIYAPNPFKEANFLQKNATSS
IIESEYLFLVDGGEDNQNIPLVPLLQKERELDVIFALDNSADTDDYWPDGASLVNTYQ
RQFGSQGLNLSFPYVPDVNTFVNLGLNKKPTFFGCDARNLTDLEYIPPLIVYIPNSRH
SFNGNQSTFKMSYSDSERLGMIKNGFEAATMGNFTDDSDFLGCVGCAIIRRKQQNLNA
TLPSECSQCFTNYCWNGTIDSRSVSGVGNDDYSSSASLSASAAAASASASASASASAS
ASGSSTHKKNAGNALVNYSNLNTNTFIGVLSVISAVFGLI"
gene complement(<283081..>283548)
/locus_tag="YMR008C-A"
/db_xref="GeneID:65052913"
mRNA complement(<283081..>283548)
/locus_tag="YMR008C-A"
/product="uncharacterized protein"
/transcript_id="NM_001395039.1"
/db_xref="GeneID:65052913"
CDS complement(283081..283548)
/locus_tag="YMR008C-A"
/note="Novel ORF identified via pan-genome analysis;
conserved in other strains of S. cerevisiae"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001381969.1"
/db_xref="GeneID:65052913"
/db_xref="SGD:S000303813"
/translation="MYDLLEQKFFVREIKFASAYYLRTGKALNNSKTPIFQRKHSLPA
WLSSAVIITAPVSNDGSHSILFARKTLRMIMPMFSPLFNRSPDDCPSHLTATHIFQQF
SAMLDYGQSTKEATNKRRLIKGSDLLVALDRNCIPSAPFVPEIALRKSGAVGS"
gene <284102..>284641
/gene="ADI1"
/locus_tag="YMR009W"
/db_xref="GeneID:855021"
mRNA <284102..>284641
/gene="ADI1"
/locus_tag="YMR009W"
/product="acireductone dioxygenase (Ni2+-requiring)"
/transcript_id="NM_001182505.1"
/db_xref="GeneID:855021"
CDS 284102..284641
/gene="ADI1"
/locus_tag="YMR009W"
/EC_number="1.13.11.54"
/EC_number="1.13.11.53"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0019509
L-methionine salvage from methylthioadenosine
[PMID:15938715]"
/experiment="EXISTENCE:mutant phenotype:GO:0010308
acireductone dioxygenase (Ni2+-requiring) activity
[PMID:15938715]"
/experiment="EXISTENCE:mutant phenotype:GO:0019509
L-methionine salvage from methylthioadenosine
[PMID:15938715|PMID:18625006]"
/note="Acireductone dioxygenease involved in methionine
salvage pathway; transcribed as polycistronic mRNA with
YMR010W and regulated post-transcriptionally by RNase III
(Rnt1p) cleavage; ADI1 mRNA is induced in heat shock
conditions; human ortholog ADI1 can complement yeast adi1
mutant"
/codon_start=1
/product="acireductone dioxygenase (Ni2+-requiring)"
/protein_id="NP_013722.1"
/db_xref="GeneID:855021"
/db_xref="SGD:S000004611"
/translation="MVKVYIHDNKVDSDYRAPHNSGTELSLDELAKLGVIYKYCANEE
EVNEIARQREYKNRDVVNICEGSFKSEAEFNEKLATFYQEHLHEDEEIRYCLEGAGYF
DVRDASTPENWIRCLVESGDLLILPPGIYHRFTLTTSNHIKALRLFKDEPKWQAINRS
NQADSLPVRKDYIALINQY"
gene <285100..>286317
/gene="ANY1"
/locus_tag="YMR010W"
/gene_synonym="CFS1"
/db_xref="GeneID:855022"
mRNA <285100..>286317
/gene="ANY1"
/locus_tag="YMR010W"
/gene_synonym="CFS1"
/product="Any1p"
/transcript_id="NM_001182506.1"
/db_xref="GeneID:855022"
CDS 285100..286317
/gene="ANY1"
/locus_tag="YMR010W"
/gene_synonym="CFS1"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0010008 endosome
membrane [PMID:28057802]"
/experiment="EXISTENCE:direct assay:GO:0032588 trans-Golgi
network membrane [PMID:28057802]"
/experiment="EXISTENCE:genetic interaction:GO:0042147
retrograde transport, endosome to Golgi [PMID:28057802]"
/experiment="EXISTENCE:genetic interaction:GO:0045332
phospholipid translocation [PMID:28057802]"
/experiment="EXISTENCE:mutant phenotype:GO:0045332
phospholipid translocation [PMID:28057802]"
/note="Protein involved in phospholipid flippase function;
null allele suppresses growth and membrane trafficking
defects associated with all flippase null alleles;
proposed function as a phospholipid scramblase that
reduces membrane asymmetry; PQ loop family member;
localizes to the endosome and trans-Golgi network;
non-essential gene"
/codon_start=1
/product="Any1p"
/protein_id="NP_013723.1"
/db_xref="GeneID:855022"
/db_xref="SGD:S000004612"
/translation="MSTTGPLDATLIRDVAVATATKASYDMSDTLYSYLPKVDQFYIP
EWLTMQFIANNLISFTPLFSYGTTIISIEKCKTALGFSIDICATMLIASILRISYYLI
TPYEITLLRQSLVMIFIQLILLRTSLKYRPDEYKYQNLTDVESLSHLIHDIWFEFFSC
INRPKFLSEDWKNLIKSLSFTNLLKFSFKIFLAFFYKILKFFDPNFKRIGAFWQWDDD
KNFWRFLALFATVQILVTFFISNILNWDSLAQGLGSIIGSLGLLVESLLPLPQIAILY
KLKSVQGFKLILLVSWLCGDTLKITYLIFGAKNISALFVIFALFQMSLDFYIGGQYIY
YRYYYPKLRHQHHPNDSNSPSDEDESEMYELDLFNTLQKDVEKALKQDSNDTSDSPQD
DQVGKSQAQAVTL"
rep_origin 286835..286951
/note="ARS1310; Autonomously Replicating Sequence"
/db_xref="SGD:S000118370"
gene <288079..>289704
/gene="HXT2"
/locus_tag="YMR011W"
/db_xref="GeneID:855023"
mRNA <288079..>289704
/gene="HXT2"
/locus_tag="YMR011W"
/product="hexose transporter HXT2"
/transcript_id="NM_001182507.1"
/db_xref="GeneID:855023"
CDS 288079..289704
/gene="HXT2"
/locus_tag="YMR011W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005355 glucose
transmembrane transporter activity [PMID:12702270]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:10191260|PMID:17507646|PMID:24124599]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0015146 pentose
transmembrane transporter activity [PMID:17180689]"
/experiment="EXISTENCE:mutant phenotype:GO:1904659 glucose
transmembrane transport [PMID:2233722]"
/note="High-affinity glucose transporter of the major
facilitator superfamily; expression is induced by low
levels of glucose and repressed by high levels of glucose"
/codon_start=1
/product="hexose transporter HXT2"
/protein_id="NP_013724.1"
/db_xref="GeneID:855023"
/db_xref="SGD:S000004613"
/translation="MSEFATSRVESGSQQTSIHSTPIVQKLETDESPIQTKSEYTNAE
LPAKPIAAYWTVICLCLMIAFGGFVFGWDTGTISGFVNQTDFKRRFGQMKSDGTYYLS
DVRTGLIVGIFNIGCAFGGLTLGRLGDMYGRRIGLMCVVLVYIVGIVIQIASSDKWYQ
YFIGRIISGMGVGGIAVLSPTLISETAPKHIRGTCVSFYQLMITLGIFLGYCTNYGTK
DYSNSVQWRVPLGLNFAFAIFMIAGMLMVPESPRFLVEKGRYEDAKRSLAKSNKVTIE
DPSIVAEMDTIMANVETERLAGNASWGELFSNKGAILPRVIMGIMIQSLQQLTGNNYF
FYYGTTIFNAVGMKDSFQTSIVLGIVNFASTFVALYTVDKFGRRKCLLGGSASMAICF
VIFSTVGVTSLYPNGKDQPSSKAAGNVMIVFTCLFIFFFAISWAPIAYVIVAESYPLR
VKNRAMAIAVGANWIWGFLIGFFTPFITSAIGFSYGYVFMGCLVFSFFYVFFFVCETK
GLTLEEVNEMYVEGVKPWKSGSWISKEKRVSEE"
repeat_region complement(290049..290224)
/note="Ty4 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007117"
gene 290801..290872
/locus_tag="YNCM0010W"
/db_xref="GeneID:855024"
tRNA 290801..290872
/locus_tag="YNCM0010W"
/product="tRNA-Glu"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE
analysis; thiolation of uridine at wobble position (34)
requires Ncs6p"
/db_xref="GeneID:855024"
/db_xref="SGD:S000006560"
gene <291134..>294967
/gene="CLU1"
/locus_tag="YMR012W"
/gene_synonym="TIF31"
/db_xref="GeneID:855025"
mRNA <291134..>294967
/gene="CLU1"
/locus_tag="YMR012W"
/gene_synonym="TIF31"
/product="translation initiation factor 3 subunit CLU1"
/transcript_id="NM_001182508.1"
/db_xref="GeneID:855025"
CDS 291134..294967
/gene="CLU1"
/locus_tag="YMR012W"
/gene_synonym="TIF31"
/experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
[PMID:7798228]"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:26777405]"
/note="Subunit of the eukaryotic translation initiation
factor 3 (eIF3); component of unknown function; deletion
causes defects in mitochondrial organization but not in
growth or translation initiation; can rescue cytokinesis
and mitochondrial organization defects of the
Dictyostelium cluA- mutant; eIF3 is also involved in
programmed stop codon readthrough"
/codon_start=1
/product="translation initiation factor 3 subunit CLU1"
/protein_id="NP_013725.1"
/db_xref="GeneID:855025"
/db_xref="SGD:S000004614"
/translation="MSEKKEEVKNATVKVTVKLPKEDNHSHNTKHLKKTQSSKNNDIS
FEIGKESKIQTVLDVLAMIPSSKYLTNVGLKTIEGDSQLSDEMSIKEIVGEKSELKLQ
LILKPYSAREALKHVITVRDFIGFAQETSDGLSEFAISTGSSFSSLPLGPIKERSKQE
EKDEKSDPEEKKNTFKDVTDEEKLKFNEMVHEVFSSFKNSSINKLLTSESNIITPCVR
SLSFAPYNPVPPFYRSKGHLFYLQIVTLEGESFYITAIPSGFYVNKSNSTKFDPSPKE
NTDENAHSSLIYYSLFDLIASRSKKFISHVQAFEKKLSALDSTSYVRPSNTFLHKPWF
VSSLPPNNPDYLRLQTAALDTTPERNFNDEFQAIKDLTTSTLQDRIEMERLFSKVVHE
FSVTAASGAMSIFYSDFVAMNPESPTRDQIFLKDNIFYSYVSDVSGNYEGKGGDEAAI
AASNQDLKTINILNRLHMHEVRYLLTTVVEFAGRRILAQTPVPGLLATMGNKIVKDAN
TGEEVTEDFVNDINVKYGLDEGLGKIVYDADFDSVLEKKFVKAFHLKKHKVNGTELAF
SSQSKGIVGFDKRRYILDLANTYPLDINFARQNFDNIEETGNRYPHRQTLLRPELVEK
WWNNKVEKEGVEFEKAYEENLFSYNPDAYQVEGIEDANVDEMSNYLQKEVIPSVIQDY
LSGNLSTPYNGEHLADTLHKNGINMRYLGKIIELSQKELDSQIVHYEQNLKAVEQDNK
EYEDWEKSYLQKIENMIKERQAKINKLVQEGKEVPKELTEDLKLNDEEIKKPTDGKPV
VVAYDELVPLIKISELEIVSRSLKHVLKDLSKDVPVFLVPSLVAYVFNMLVGINYNAD
PKPEPVDEFYPVNKCSFAKLTRSELLEAVSKQAFLRFRHQLPSNWIEAYMENPFTLIR
SVSYKFGIQLLNKEYFFTREQLESYKQSLDKKIRNKFVEPPTTFSLSDLTIIPRVKFS
EYTSSVSEEFWAQGASMINEDKQSALTLLAQSITVLEDVNNILHPAVAEKYLSLSAIY
NKLALYPEAIAFCRKACTIYERVSGIDSFEMMRALTNLAILEFSNESPYNATVVYNRL
AEILKVYELPKIHHPAPTSIFNHLEQLALGVQDTKLAIEVLGQLSSYVVELEGKDSLA
YGYTESRLGNLFAALKDFHRALEHITVTQGIFTKQLGMNHTHSAQSRQWVNGLSSLIM
DLKQKKQLAQDQMSTTGSNSAGHKKTNHRQKKDDVKPELANKSVDELLTFIEGDSSNS
KSKNKTNNKKKHGKK"
gene complement(<295179..>296738)
/gene="SEC59"
/locus_tag="YMR013C"
/db_xref="GeneID:855026"
mRNA complement(<295179..>296738)
/gene="SEC59"
/locus_tag="YMR013C"
/product="dolichol kinase"
/transcript_id="NM_001182509.1"
/db_xref="GeneID:855026"
CDS complement(295179..296738)
/gene="SEC59"
/locus_tag="YMR013C"
/EC_number="2.7.1.108"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:2657387]"
/experiment="EXISTENCE:genetic interaction:GO:0004168
dolichol kinase activity [PMID:12213788]"
/experiment="EXISTENCE:genetic interaction:GO:0043048
dolichyl monophosphate biosynthetic process
[PMID:12213788]"
/experiment="EXISTENCE:mutant phenotype:GO:0004168
dolichol kinase activity [PMID:2657387|PMID:12213788]"
/experiment="EXISTENCE:mutant phenotype:GO:0005789
endoplasmic reticulum membrane [PMID:2657387]"
/experiment="EXISTENCE:mutant phenotype:GO:0043048
dolichyl monophosphate biosynthetic process
[PMID:12213788|PMID:1323123]"
/note="Dolichol kinase; catalyzes the terminal step in
dolichyl monophosphate (Dol-P) biosynthesis; required for
viability and for normal rates of lipid intermediate
synthesis and protein N-glycosylation"
/codon_start=1
/product="dolichol kinase"
/protein_id="NP_013726.1"
/db_xref="GeneID:855026"
/db_xref="SGD:S000004615"
/translation="MVAIIPHASFTTIKLTQKTEGSQMPTEEICKINMRTRKFDVGGN
SRDFECFYSNFVQTVILLGTFFYCVERLQPWSIVTADISYKQIFVNVFVVCLIMVGLI
FTKYWQHGYKSLPKFDTIYSLYLPFMVSLLFDTSSTVINTILILSVLNSYRWRTQLVV
IILQLCLIFFNFEAGDRLKNIISIVINSLLSLILKYIGQLKSLDNIDSNLFSILLTNI
LYVSEAGTVHFRILKGIILALTTIISINYVLKKVMHFKPFMLSISFAIGLPLFANTFI
HLEDGENPLLWLVKYILESTIRQKILFAWSSILILSIPSILIEKDSLSLNTSRKLWHF
IIFLLIIPSFQMDSNFVKIALSGTIPVFLSIEYIRFQNLPPLGSAIELQLRRFADDRD
HSGPLIISYLYLLFGISTPLLMNNSPMGLIGLGIGDSLASIIGKRYGRIRWKGTQKTL
EGTLAFIVTSFIVCLVLLRFDKAAIFNHLTTLQLLTLCTLSGVLEGNSVLNDNILIPA
FMMICEKLITL"
gene 297278..297364
/gene="SNR78"
/locus_tag="YNCM0011W"
/db_xref="GeneID:9164958"
ncRNA 297278..297364
/ncRNA_class="snoRNA"
/gene="SNR78"
/locus_tag="YNCM0011W"
/product="SNR78"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:direct assay:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:9891049]"
/experiment="EXISTENCE:direct assay:GO:0031167 rRNA
methylation [PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity
[PMID:18726517|PMID:10024243|PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:18726517|PMID:10024243|PMID:9891049]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of large subunit (LSU) rRNA at position
U2421"
/transcript_id="NR_132237.1"
/db_xref="GeneID:9164958"
/db_xref="SGD:S000007312"
gene 297506..297593
/gene="SNR77"
/locus_tag="YNCM0012W"
/db_xref="GeneID:9164954"
ncRNA 297506..297593
/ncRNA_class="snoRNA"
/gene="SNR77"
/locus_tag="YNCM0012W"
/product="SNR77"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:direct assay:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:9891049]"
/experiment="EXISTENCE:direct assay:GO:0031167 rRNA
methylation [PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity
[PMID:10024243|PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:10024243|PMID:9891049]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of small subunit (SSU) rRNA at position
U578"
/transcript_id="NR_132238.1"
/db_xref="GeneID:9164954"
/db_xref="SGD:S000007311"
gene 297725..297833
/gene="SNR76"
/locus_tag="YNCM0013W"
/db_xref="GeneID:9164962"
ncRNA 297725..297833
/ncRNA_class="snoRNA"
/gene="SNR76"
/locus_tag="YNCM0013W"
/product="SNR76"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:direct assay:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:9891049]"
/experiment="EXISTENCE:direct assay:GO:0031167 rRNA
methylation [PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity
[PMID:10024243|PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:10024243|PMID:9891049]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of large subunit (LSU) rRNA at position
C2197"
/transcript_id="NR_132239.1"
/db_xref="GeneID:9164962"
/db_xref="SGD:S000007310"
gene 297918..298006
/gene="SNR75"
/locus_tag="YNCM0014W"
/db_xref="GeneID:9164956"
ncRNA 297918..298006
/ncRNA_class="snoRNA"
/gene="SNR75"
/locus_tag="YNCM0014W"
/product="SNR75"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:direct assay:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:9891049]"
/experiment="EXISTENCE:direct assay:GO:0031167 rRNA
methylation [PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity
[PMID:10024243|PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:10024243|PMID:9891049]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of large subunit (LSU) rRNA at position
G2288"
/transcript_id="NR_132240.1"
/db_xref="GeneID:9164956"
/db_xref="SGD:S000007309"
gene 298138..298225
/gene="SNR74"
/locus_tag="YNCM0015W"
/db_xref="GeneID:9164964"
ncRNA 298138..298225
/ncRNA_class="snoRNA"
/gene="SNR74"
/locus_tag="YNCM0015W"
/product="SNR74"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:direct assay:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:9891049]"
/experiment="EXISTENCE:direct assay:GO:0031167 rRNA
methylation [PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity
[PMID:10024243|PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:10024243|PMID:9891049]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of small subunit (SSU) rRNA at position
A28"
/transcript_id="NR_132241.1"
/db_xref="GeneID:9164964"
/db_xref="SGD:S000007308"
gene 298307..298412
/gene="SNR73"
/locus_tag="YNCM0016W"
/db_xref="GeneID:9164963"
ncRNA 298307..298412
/ncRNA_class="snoRNA"
/gene="SNR73"
/locus_tag="YNCM0016W"
/product="SNR73"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:direct assay:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:9891049]"
/experiment="EXISTENCE:direct assay:GO:0031167 rRNA
methylation [PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity
[PMID:10024243|PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:10024243|PMID:9891049]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of large subunit (LSU) rRNA at position
C2959"
/transcript_id="NR_132242.1"
/db_xref="GeneID:9164963"
/db_xref="SGD:S000007307"
gene 298554..298651
/gene="SNR72"
/locus_tag="YNCM0017W"
/db_xref="GeneID:9164953"
ncRNA 298554..298651
/ncRNA_class="snoRNA"
/gene="SNR72"
/locus_tag="YNCM0017W"
/product="SNR72"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:10024243]"
/experiment="EXISTENCE:curator inference:GO:0031428 box
C/D RNP complex [PMID:10024243]"
/experiment="EXISTENCE:direct assay:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:9891049]"
/experiment="EXISTENCE:direct assay:GO:0031167 rRNA
methylation [PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity
[PMID:10024243|PMID:9891049]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:10024243|PMID:9891049]"
/note="C/D box small nucleolar RNA (snoRNA); guides
2'-O-methylation of large subunit (LSU) rRNA at position
A876"
/transcript_id="NR_132243.1"
/db_xref="GeneID:9164953"
/db_xref="SGD:S000007306"
gene <298868..>300427
/gene="BUD22"
/locus_tag="YMR014W"
/db_xref="GeneID:855028"
mRNA <298868..>300427
/gene="BUD22"
/locus_tag="YMR014W"
/product="Bud22p"
/transcript_id="NM_001182510.1"
/db_xref="GeneID:855028"
CDS 298868..300427
/gene="BUD22"
/locus_tag="YMR014W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11452010]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:19806183]"
/experiment="EXISTENCE:mutant phenotype:GO:0030490
maturation of SSU-rRNA [PMID:20498295]"
/experiment="EXISTENCE:mutant phenotype:GO:0042274
ribosomal small subunit biogenesis
[PMID:20498295|PMID:19806183]"
/note="Protein required for rRNA maturation and ribosomal
subunit biogenesis; required for 18S rRNA maturation; also
required for small ribosomal subunit biogenesis;
cosediments with pre-ribosomal particles; mutation
decreases efficiency of +1 Ty1 frameshifting and
transposition, and affects budding pattern"
/codon_start=1
/product="Bud22p"
/protein_id="NP_013727.1"
/db_xref="GeneID:855028"
/db_xref="SGD:S000004616"
/translation="MPSESSVSIYKLDQLEYQYHYLTKSLQKFEPRYPKTAKLYNCIG
KKNKKKIEKLLNSLELKTLDKELDESYSKLLNNKIHYYETHLSKCIKEQIQKISKKNS
SKVKDAQKNKSPSIDIEKMLATQLSLDDLALFMTRFRLIKILHQRIKQKSKKIEGDTN
NKTWLNNNDYSGYINDKTSKWNPSNIWNEVITKLPSCEKLNALIGQSKIVQNLTESFD
LSICLIFGFDVSAMKAKKYGAREKTANANQTHSNIDYDTDDGNEKNAIDSKSNAIGAQ
TQSNKETTSDNEDLLIKEYEGMLGSSGDEGEGGGYLNPNINYNEVTDEEPSEASSDED
DSDERFSDSEENEPRRKKPKLHNLPELMAGYYSGNDTEEESDEDNKNVKGKKKKRDTA
EDRTAREQMSNEPKRKNRRGQRARRKIWEKKYGSQAKHVQRELEKEMEDRKQRQIEYE
ARVAKREAKAASLEASRSREREDRRTETNNKKEKESASTGEEHPSWIAKRLAEEKLQK
AKFEGKKIKFD"
gene complement(<300869..>302485)
/gene="ERG5"
/locus_tag="YMR015C"
/gene_synonym="CYP61"
/db_xref="GeneID:855029"
mRNA complement(<300869..>302485)
/gene="ERG5"
/locus_tag="YMR015C"
/gene_synonym="CYP61"
/product="C-22 sterol desaturase"
/transcript_id="NM_001182511.1"
/db_xref="GeneID:855029"
CDS complement(300869..302485)
/gene="ERG5"
/locus_tag="YMR015C"
/gene_synonym="CYP61"
/EC_number="1.14.19.41"
/experiment="EXISTENCE:direct assay:GO:0000249 C-22 sterol
desaturase activity [PMID:8543054]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0006696 ergosterol
biosynthetic process [PMID:8543054]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process [PMID:8635732]"
/note="C-22 sterol desaturase; a cytochrome P450 enzyme
that catalyzes the formation of the C-22(23) double bond
in the sterol side chain in ergosterol biosynthesis; may
be a target of azole antifungal drugs"
/codon_start=1
/product="C-22 sterol desaturase"
/protein_id="NP_013728.1"
/db_xref="GeneID:855029"
/db_xref="SGD:S000004617"
/translation="MSSVAENIIQHATHNSTLHQLAKDQPSVGVTTAFSILDTLKSMS
YLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWPIIGPFLESLDPKFEEYKAKWAS
GPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHT
DYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCAL
SLNSFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFE
NCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFL
FASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMV
IKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIP
ERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSE
KIKVFATIFPKDDLLLTFKKRDPITGEVFE"
gene complement(<303236..>305593)
/gene="SOK2"
/locus_tag="YMR016C"
/db_xref="GeneID:855030"
mRNA complement(<303236..>305593)
/gene="SOK2"
/locus_tag="YMR016C"
/product="Sok2p"
/transcript_id="NM_001182512.1"
/db_xref="GeneID:855030"
CDS complement(303236..305593)
/gene="SOK2"
/locus_tag="YMR016C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:mutant phenotype:GO:0007124
pseudohyphal growth [PMID:11046133|PMID:8524252]"
/note="Nuclear protein that negatively regulates
pseudohyphal differentiation; plays a regulatory role in
the cyclic AMP (cAMP)-dependent protein kinase (PKA)
signal transduction pathway; relocalizes to the cytosol in
response to hypoxia; SOK2 has a paralog, PHD1, that arose
from the whole genome duplication"
/codon_start=1
/product="Sok2p"
/protein_id="NP_013729.1"
/db_xref="GeneID:855030"
/db_xref="SGD:S000004618"
/translation="MPIGNPINTNDIKSNRMRQESNMSAVSNSESTIGQSTQQQQQQQ
QYLGQSVQPLMPVSYQYVVPEQWPYPQYYQQPQSQSQQQLQSQPQMYQVQESFQSSGS
DSNASNPPSTSVGVPSNATATALPNGSAITTKKSNNSTNISNNVPYYYYFPQMQAQQS
MAYSYPQAYYYYPANGDGTTNGATPSVTSNQVQNPNLEKTYSTFEQQQQHQQQQQLQA
QTYPAQPPKIGNAFSKFSKSGPPSDSSSGSMSPNSNRTSRNSNSISSLAQQPPMSNYP
QPSTYQYPGFHKTSSIPNSHSPIPPRSLTTPTQGPTSQNGPLSYNLPQVGLLPPQQQQ
QVSPLYDGNSITPPVKPSTDQETYLTANRHGVSDQQYDSMAKTMNSFQTTTIRHPMPL
IATTNATGSNTSGTSASIIRPRVTTTMWEDEKTLCYQVEANGISVVRRADNDMVNGTK
LLNVTKMTRGRRDGILKAEKIRHVVKIGSMHLKGVWIPFERALAIAQREKIADYLYPL
FIRDIQSVLKQNNPSNDSSSSSSSTGIKSISPRTYYQPINNYQNPNGPSNISAAQLTY
SSMNLNNKIIPNNSIPAVSTIAAGEKPLKKCTMPNSNQLEGHTITNLQTLSATMPMKQ
QLMGNIASPLSYPRNATMNSASTLGITPADSKPLTPSPTTTNTNQSSESNVGSIHTGI
TLPRVESESASHSKWSKEADSGNTVPDNQTLKEPRSSQLPISALTSTDTDKIKTSTSD
EATQPNEPSEAEPVKESESSKSQVDGAGDVSNEEIAADDTKKQEK"
gene <307489..>308682
/gene="SPO20"
/locus_tag="YMR017W"
/gene_synonym="DBI9"
/db_xref="GeneID:855031"
mRNA <307489..>308682
/gene="SPO20"
/locus_tag="YMR017W"
/gene_synonym="DBI9"
/product="Spo20p"
/transcript_id="NM_001182513.1"
/db_xref="GeneID:855031"
CDS 307489..308682
/gene="SPO20"
/locus_tag="YMR017W"
/gene_synonym="DBI9"
/experiment="EXISTENCE:direct assay:GO:0005546
phosphatidylinositol-4,5-bisphosphate binding
[PMID:14742704]"
/experiment="EXISTENCE:direct assay:GO:0005628 prospore
membrane [PMID:14742704]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14742704]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:14742704]"
/experiment="EXISTENCE:direct assay:GO:0031201 SNARE
complex [PMID:10924463]"
/experiment="EXISTENCE:direct assay:GO:0070300
phosphatidic acid binding [PMID:14742704|PMID:27480805]"
/experiment="EXISTENCE:mutant phenotype:GO:0005628
prospore membrane [PMID:9425151]"
/experiment="EXISTENCE:mutant phenotype:GO:0031321
ascospore-type prospore assembly [PMID:9425151]"
/experiment="EXISTENCE:physical interaction:GO:0005484
SNAP receptor activity [PMID:10924463]"
/note="Meiosis-specific subunit of the t-SNARE complex;
required for prospore membrane formation during
sporulation; similar to but not functionally redundant
with Sec9p; binds to phosphatidic acid; SNAP-25 homolog"
/codon_start=1
/product="Spo20p"
/protein_id="NP_013730.1"
/db_xref="GeneID:855031"
/db_xref="SGD:S000004619"
/translation="MGFRKILASKSHHSRHHNQHHKNLKLQNHRYVLISNITGSHETK
YLSPFRMDNCSGSRRRDRLHVKLKSLRNKIHKQLHPNCRFDDATKTSDDKCVSYEVPE
RDGLATISLEEVFPKSNRCQIPEENLGETDSVIHRDLGNFANENDYPQWRKVESQYNL
ENVQPEEDEIVDRLRSEIRSTKLKSVKTTSRTLEKAIEARCTGKRVLQQLSCQSNQLT
KIESNCDMLKIQSNVADRKIDELAHENRSLLALKSPNPFRKKREREKRDQIYNLKLKH
RHLQQETMKRAQDSDKNLAINLSSEYGRYGQGVERQRILRDAQKYQFEADEEDNQMEI
DLYGNLEQIKAVSGDLKIMAHAFGREFEAQNTRMFDIENNVQQADNALQAKRYRLEKV
IGKRW"
gene <310208..>311752
/gene="PEX9"
/locus_tag="YMR018W"
/db_xref="GeneID:855032"
mRNA <310208..>311752
/gene="PEX9"
/locus_tag="YMR018W"
/product="Pex9p"
/transcript_id="NM_001182514.1"
/db_xref="GeneID:855032"
CDS 310208..311752
/gene="PEX9"
/locus_tag="YMR018W"
/experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
[PMID:27663510]"
/experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal
membrane [PMID:27678487]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:27678487]"
/experiment="EXISTENCE:genetic interaction:GO:0016558
protein import into peroxisome matrix
[PMID:27663510|PMID:27678487]"
/experiment="EXISTENCE:mutant phenotype:GO:0016558 protein
import into peroxisome matrix [PMID:27663510]"
/experiment="EXISTENCE:physical interaction:GO:0016558
protein import into peroxisome matrix [PMID:27678487]"
/note="Peroxisomal membrane signal receptor for
peroxisomal matrix proteins; oleate-inducible
condition-specific import receptor for a subset of
PTS1-containing matrix proteins; localizes to both the
cytosol and the peroxisomal membrane; similar to human
PEX5Rp, a peroxin protein 5 related protein; paralog of
Pex5p"
/codon_start=1
/product="Pex9p"
/protein_id="NP_013731.1"
/db_xref="GeneID:855032"
/db_xref="SGD:S000004620"
/translation="MNEVTCSITGDNPIHKINNGLGLKWNNLGKFSDFQTNDSAARDA
RTIDYIFTNCQTGSSIGKIDFRAALPADKSQHSGVSEKEFSRLENQWSKEFSCFPKNK
NADVTKPSRNKHEKRSANLHNRYFAQYYSTAYQQNRIYPCRISYNEHSSVSNGWEFQF
KSIENQLLNELKIENNVEEKTVGYEYVAEYEETIDFMHMLSSVPQTYQFLKSNIYITE
RDPYKIGCVLMDNGSNLNEVVMAFEAAISQDPSHINAWLKLGIVNFENESESNGELAL
RNCLNLDPNNTIALENLAIHHINQQNESESLKLFHKWILSKFSKVFQPSAGENKDSIN
KIPKKAHLAHILESLLNMGIEKKDQYDIYSVLSILYYSDQKIKQSQKCLEFLLLEKPN
NGTIWNRYGAILANTKSYHSAINAYNKCKQLRPNFTRVRYNLAIAYMNKGDYVKASKM
LIEVILLRSKGYEHNKAKMQNKFMQNLKNALIASKNFDSLDLINGSHNTESLISTLKA
IYNKMD"
gene <312156..>315005
/gene="STB4"
/locus_tag="YMR019W"
/db_xref="GeneID:855033"
mRNA <312156..>315005
/gene="STB4"
/locus_tag="YMR019W"
/product="Stb4p"
/transcript_id="NM_001182515.1"
/db_xref="GeneID:855033"
CDS 312156..315005
/gene="STB4"
/locus_tag="YMR019W"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding [PMID:19111667]"
/note="Putative transcription factor; contains a
Zn(II)2Cys6 zinc finger domain characteristic of
DNA-binding proteins; computational analysis suggests a
role in regulation of expression of genes encoding
transporters; binds Sin3p in a two-hybrid assay"
/codon_start=1
/product="Stb4p"
/protein_id="NP_013732.1"
/db_xref="GeneID:855033"
/db_xref="SGD:S000004621"
/translation="MSINHEIYYILVFEHRSVAIKLIIVVIVLLQFFLARSRQIDRTW
AHTNRKERFREMTAIGNTDDALDTSTAASKENGKGRLRVQKACELCKKRKVKCDGNNP
CLNCSKHQKECRYDFKATNRKRRRRQVASAVRDVSKTYAETSESFPRDLLSKSNIIIN
APSDGVSSSASNSPNPNSHYHHISSTLPFMSGRPNHTFHSGSNLNGENNNNSFPEDHM
AKLLLQLSSKLGNTTKESSIRTTRTNASDVNANPTVVNMKNSQEDCDTNHRSAICDSA
EALHNNNINSKENKIINSQITNTVNDHFESPWQTFSLDKYRFHRRYQNILPYYLGVSI
LKDLSPQTIEYAKLKRPRVQNYGWNLSGGHYLKYKGDFRSQEKNIRHESKFFDFDDPV
HLSLINKLLRYYFDEINPVFSIIHEATFWQQYNNKFLRQGKQNNSSANLFTSMLYLIL
STTLRFREGHLDGQKGQGTYSNTSLNITFEEKSILIKKPSIEENLFKYAYLIINTLTF
EWESFELIQSWLLITFYFRTCYRQTACWNALSQAVNMCNGMSLYLNKFPEIHSTYDES
KAWHCFWCCFIMDKLISFQMGRFYQLSLPASEMCEQMNLVKSKKFLQEEDDWFHEETF
QMLDLSIIVTQFLKRDAQDLNLNETVQLRSQLGQWYDTFIVGSQTNAYDDNYRYFYQV
QPFMTYLDIRLTFEVRQLFCLIAPSSTANNKSLEYVVDTELLISHCQMAIENLAEITR
SNLFFVPWWLNLSQLFTVNLICIIYLHAGIAVTQNKAIMQSCQEIWRTLECSKPKNRP
SMLPECLWCLKMLNHMFCIRLRDSALQLEATLGTDHGDDTPNRNKFEQFKKVGDNDAD
VEVDAGEREENADERQENPHNNSKRVPLATRSHNTTNFDGSIAISPESAVANLGTDTG
LPSDVLDTVSKIGNSPNVFDDDLFSNLLWFDQNFA"
gene <315377..>316903
/gene="FMS1"
/locus_tag="YMR020W"
/db_xref="GeneID:855034"
mRNA <315377..>316903
/gene="FMS1"
/locus_tag="YMR020W"
/product="polyamine oxidase"
/transcript_id="NM_001182516.1"
/db_xref="GeneID:855034"
CDS 315377..316903
/gene="FMS1"
/locus_tag="YMR020W"
/EC_number="1.5.3.17"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0046592 polyamine
oxidase activity [PMID:21067138]"
/experiment="EXISTENCE:genetic interaction:GO:0046208
spermine catabolic process [PMID:12586697]"
/experiment="EXISTENCE:mutant phenotype:GO:0015940
pantothenate biosynthetic process [PMID:11154694]"
/experiment="EXISTENCE:mutant phenotype:GO:0046208
spermine catabolic process [PMID:12586697]"
/experiment="EXISTENCE:mutant phenotype:GO:0046592
polyamine oxidase activity [PMID:11154694]"
/note="Polyamine oxidase; converts spermine to spermidine,
which is required for the essential hypusination
modification of translation factor eIF-5A; also involved
in pantothenic acid biosynthesis"
/codon_start=1
/product="polyamine oxidase"
/protein_id="NP_013733.1"
/db_xref="GeneID:855034"
/db_xref="SGD:S000004622"
/translation="MNTVSPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRV
GGRLQTVTGYQGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDE
ERGRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQ
IRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNWLK
LSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQP
PLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLD
ELDSMLEREDSQKHTSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKE
RLFSFFQPVLNKIMKCLDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAY
SACFPGDDPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLK
"
gene complement(<317165..>318418)
/gene="MAC1"
/locus_tag="YMR021C"
/gene_synonym="CUA1"
/db_xref="GeneID:855035"
mRNA complement(<317165..>318418)
/gene="MAC1"
/locus_tag="YMR021C"
/gene_synonym="CUA1"
/product="Mac1p"
/transcript_id="NM_001182517.1"
/db_xref="GeneID:855035"
CDS complement(317165..318418)
/gene="MAC1"
/locus_tag="YMR021C"
/gene_synonym="CUA1"
/experiment="EXISTENCE:direct assay:GO:0000987
cis-regulatory region sequence-specific DNA binding
[PMID:9867833]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:8262047]"
/experiment="EXISTENCE:direct assay:GO:0045944 positive
regulation of transcription by RNA polymerase II
[PMID:9159110]"
/experiment="EXISTENCE:mutant phenotype:GO:0001228
DNA-binding transcription activator activity, RNA
polymerase II-specific [PMID:10887177]"
/experiment="EXISTENCE:mutant phenotype:GO:0006878
intracellular copper ion homeostasis
[PMID:8262047|PMID:9211922]"
/experiment="EXISTENCE:mutant phenotype:GO:0045732
positive regulation of protein catabolic process
[PMID:12011036]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:8262047]"
/note="Copper-sensing transcription factor; involved in
regulation of genes required for high affinity copper
transport; required for regulation of yeast copper genes
in response to DNA-damaging agents; undergoes changes in
redox state in response to changing levels of copper or
MMS"
/codon_start=1
/product="Mac1p"
/protein_id="NP_013734.1"
/db_xref="GeneID:855035"
/db_xref="SGD:S000004623"
/translation="MIIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPSPMAI
RDAILVDSTSQSTEYENGAQIEGDCCSAMNQQPILFVRASAVRKARMINGKLHILMEE
GFTAHEPKDISTFTDDGNKYITETEFLRKHSPKAPATGTISPDSTKSSSSSEKKERSR
LQQEPIRHFSNCCKKDKSQNPASNGKTNKAPSDDIFTPYGSLESTSAFNDILQENYNS
SVPGAHDSSETLTPQSTTTIAAPHSSDVASKVEVLTHKGIFLSTQCSCEDESCPCVNC
LIHRSEEELNSYIQQSGVPLTNIGEAQITDKMMDYLDDCKCTDKECICPPDNCTCDGC
FSHSTNIIPFEKFFFYGILNARLTRKTQIKFKGKLVPSKYWWDFLKLQVPLMTDAQLE
LLDIHAWFQKLVSNYAPHLSDATTS"
gene <318680..>319177
/gene="UBC7"
/locus_tag="YMR022W"
/gene_synonym="DER2; QRI8"
/db_xref="GeneID:855036"
mRNA <318680..>319177
/gene="UBC7"
/locus_tag="YMR022W"
/gene_synonym="DER2; QRI8"
/product="E2 ubiquitin-conjugating protein UBC7"
/transcript_id="NM_001182518.1"
/db_xref="GeneID:855036"
CDS 318680..319177
/gene="UBC7"
/locus_tag="YMR022W"
/gene_synonym="DER2; QRI8"
/EC_number="2.3.2.23"
/experiment="EXISTENCE:direct assay:GO:0000837 Doa10p
ubiquitin ligase complex [PMID:16873065|PMID:16873066]"
/experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p
ubiquitin ligase ERAD-L complex
[PMID:16873065|PMID:16873066]"
/experiment="EXISTENCE:direct assay:GO:0004842
ubiquitin-protein transferase activity [PMID:9172777]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:9388185]"
/experiment="EXISTENCE:direct assay:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:12105183]"
/experiment="EXISTENCE:genetic interaction:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:8641272]"
/experiment="EXISTENCE:genetic interaction:GO:0031505
fungal-type cell wall organization [PMID:18971375]"
/experiment="EXISTENCE:mutant phenotype:GO:0006325
chromatin organization [PMID:15643069]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway
[PMID:8641272|PMID:8781238]"
/experiment="EXISTENCE:physical interaction:GO:0005515
protein binding [PMID:29519818]"
/note="Ubiquitin conjugating enzyme; involved in the
ER-associated protein degradation (ERAD) pathway and in
the inner nuclear membrane-associated degradation (INMAD)
pathway; requires Cue1p for recruitment to the ER
membrane; proposed to be involved in chromatin assembly"
/codon_start=1
/product="E2 ubiquitin-conjugating protein UBC7"
/protein_id="NP_013735.1"
/db_xref="GeneID:855036"
/db_xref="SGD:S000004624"
/translation="MSKTAQKRLLKELQQLIKDSPPGIVAGPKSENNIFIWDCLIQGP
PDTPYADGVFNAKLEFPKDYPLSPPKLTFTPSILHPNIYPNGEVCISILHSPGDDPNM
YELAEERWSPVQSVEKILLSVMSMLSEPNIESGANIDACILWRDNRPEFERQVKLSIL
KSLGF"
gene complement(<319437..>321017)
/gene="MSS1"
/locus_tag="YMR023C"
/gene_synonym="PET53"
/db_xref="GeneID:855037"
mRNA complement(<319437..>321017)
/gene="MSS1"
/locus_tag="YMR023C"
/gene_synonym="PET53"
/product="Mss1p"
/transcript_id="NM_001182519.1"
/db_xref="GeneID:855037"
CDS complement(319437..321017)
/gene="MSS1"
/locus_tag="YMR023C"
/gene_synonym="PET53"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:11604502]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0070899
mitochondrial tRNA wobble uridine modification
[PMID:15509579]"
/note="Mitochondrial protein; forms a heterodimer complex
with Mto1p that performs the 5-carboxymethylaminomethyl
modification of the wobble uridine base in mitochondrial
tRNAs; similar to human GTPBP3"
/codon_start=1
/product="Mss1p"
/protein_id="NP_013736.1"
/db_xref="GeneID:855037"
/db_xref="SGD:S000004625"
/translation="MNSASFLQSRLISRSFLVRRSLKRYSGLAKPYTFQQPTIYALST
PANQTSAIAIIRISGTHAKYIYNRLVDSSTVPPIRKAILRNIYSPSSCSVKPHDQKES
KILLDTSLLLYFQAPYSFTGEDVLELHVHGGKAVVNSILKAIGSLHDRSSGKDIRFAL
PGDFSRRAFQNGKFDLTQLEGIKDLIDSETESQRRSALSSFNGDNKILFENWRETIIE
NMAQLTAIIDFADDNSQEIQNTDEIFHNVEKNIICLRDQIVTFMQKVEKSTILQNGIK
LVLLGAPNVGKSSLVNSLTNDDISIVSDIPGTTRDSIDAMINVNGYKVIICDTAGIRE
KSSDKIEMLGIDRAKKKSVQSDLCLFIVDPTDLSKLLPEDILAHLSSKTFGNKRIIIV
VNKSDLVSDDEMTKVLNKLQTRLGSKYPILSVSCKTKEGIESLISTLTSNFESLSQSS
ADASPVIVSKRVSEILKNDVLYGLEEFFKSKDFHNDIVLATENLRYASDGIAKITGQA
IGIEEILDSVFSKFCIGK"
gene complement(321147..321219)
/locus_tag="YNCM0018C"
/db_xref="GeneID:855038"
tRNA complement(321147..321219)
/locus_tag="YNCM0018C"
/product="tRNA-Ala"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE
analysis; one of 11 nuclear tRNA genes containing the
tDNA-anticodon AGC (converted to IGC in the mature tRNA),
decodes GCU and GCC codons into alanine, one of 16 nuclear
tRNAs for alanine"
/db_xref="GeneID:855038"
/db_xref="SGD:S000006518"
gene <321875..>323047
/gene="MRPL3"
/locus_tag="YMR024W"
/gene_synonym="mL44"
/db_xref="GeneID:855039"
mRNA <321875..>323047
/gene="MRPL3"
/locus_tag="YMR024W"
/gene_synonym="mL44"
/product="mitochondrial 54S ribosomal protein YmL3"
/transcript_id="NM_001182520.1"
/db_xref="GeneID:855039"
CDS 321875..323047
/gene="MRPL3"
/locus_tag="YMR024W"
/gene_synonym="mL44"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:12392552]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:12392552]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005762
mitochondrial large ribosomal subunit [PMID:12392552]"
/note="Mitochondrial ribosomal protein of the large
subunit; located in close proximity to the polypeptide
exit channel of the ribosome; mutations in human homolog
MRPL44 cause childhood cardiomyopathy; human MRPL44
deficiency results in inefficient assembly of the
mitochondrial ribosome, and in tissue-specific respiratory
chain deficiency, manifesting as either Complex I+Complex
IV or Complex IV deficiency, depending on a cell type"
/codon_start=1
/product="mitochondrial 54S ribosomal protein YmL3"
/protein_id="NP_013737.1"
/db_xref="GeneID:855039"
/db_xref="SGD:S000004626"
/translation="MGIVLKRAIAAGMKPFPNSTWHWSRTIRPFSQHLSSTCFLQQSS
RFTSKRYLHLSTLTQQEKRFLPESELAKYKEYYQGLKSTVNEIPESVASKSPSLRTLH
KRLQLPNELTYSTLSRCLTCPSAKLPDKINNPTKGAAFVNTVPTNKYLDNHGLNIMGK
NLLSYHVTKSIIQKYPRLPTVVLNAAVNAYISEAVLAHIAKYWGIEVETTSVLSRYLK
MEPFEFTLGRLKFFNNSLNSKDGIELITGKNFSETSALAMSVRSIIAAIWAVTEQKDS
QAVYRFIDDHIMSRKLDITKMFQFEQPTRELAMLCRREGLEKPVSKLVAESGRLSKSP
VFIVHVFSGEETLGEGYGSSLKEAKARAATDALMKWYCYEPLAQQEPVIDPGTVVV"
gene <323300..>324187
/gene="CSI1"
/locus_tag="YMR025W"
/db_xref="GeneID:855040"
mRNA <323300..>324187
/gene="CSI1"
/locus_tag="YMR025W"
/product="Csi1p"
/transcript_id="NM_001182521.1"
/db_xref="GeneID:855040"
CDS 323300..324187
/gene="CSI1"
/locus_tag="YMR025W"
/experiment="EXISTENCE:direct assay:GO:0008180 COP9
signalosome [PMID:12446563]"
/experiment="EXISTENCE:mutant phenotype:GO:0000338 protein
deneddylation [PMID:12186635|PMID:12446563]"
/experiment="EXISTENCE:mutant phenotype:GO:0000754
adaptation of signaling pathway by response to pheromone
involved in conjugation with cellular fusion
[PMID:12446563]"
/note="Subunit of the Cop9 signalosome; which is required
for deneddylation, or removal of the ubiquitin-like
protein Rub1p from Cdc53p (cullin); involved in adaptation
to pheromone signaling; functional equivalent of canonical
Csn6 subunit of the COP9 signalosome"
/codon_start=1
/product="Csi1p"
/protein_id="NP_013738.1"
/db_xref="GeneID:855040"
/db_xref="SGD:S000004627"
/translation="MDLLKFSSLAISEINFLHESSFDSIDHSWFLLIGCKLDQDDEIY
IPINGNEAESQWYIEKVIRIPMQENDKINQERLERRINLTKVTQKDICILGILDLCQL
EEDENITNKVTEKVLTQLTALALKYLIKYNVFRQHTSFQEAVNSLKGYKIENSVQIGA
EIILDFLQDKVQIKDVNDRYQIPTPNNTVDPGFDEFQLIDMKDKEINIQKYNNNTIRK
LLEKINRMIIFLKNYDATDKPFSSTQDVILRKISMLVTQLQRGGTSDMNYLLDNKINE
IKLLEISCKQWEISNMLKK"
gene complement(<324236..>325435)
/gene="PEX12"
/locus_tag="YMR026C"
/gene_synonym="PAS11"
/db_xref="GeneID:855041"
mRNA complement(<324236..>325435)
/gene="PEX12"
/locus_tag="YMR026C"
/gene_synonym="PAS11"
/product="ubiquitin-protein ligase peroxin 12"
/transcript_id="NM_001182522.1"
/db_xref="GeneID:855041"
CDS complement(324236..325435)
/gene="PEX12"
/locus_tag="YMR026C"
/gene_synonym="PAS11"
/experiment="EXISTENCE:direct assay:GO:0000209 protein
polyubiquitination [PMID:35768507]"
/experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal
membrane [PMID:35768507|PMID:11370741]"
/experiment="EXISTENCE:direct assay:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:35768507]"
/experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin
protein ligase activity [PMID:19687296|PMID:22471590]"
/experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal
importomer complex [PMID:22375831]"
/experiment="EXISTENCE:direct assay:GO:1990757 ubiquitin
ligase activator activity [PMID:35768507]"
/experiment="EXISTENCE:mutant phenotype:GO:0016558 protein
import into peroxisome matrix
[PMID:11370741|PMID:15536088|PMID:9090384]"
/experiment="EXISTENCE:physical interaction:GO:0005515
protein binding [PMID:12667447]"
/note="C3HC4-type RING-finger peroxin and E3 ubiquitin
ligase; required for peroxisome biogenesis and peroxisomal
matrix protein import; forms translocation subcomplex with
Pex2p and Pex10p; mutations in human homolog cause
peroxisomal disorder"
/codon_start=1
/product="ubiquitin-protein ligase peroxin 12"
/protein_id="NP_013739.1"
/db_xref="GeneID:855041"
/db_xref="SGD:S000004628"
/translation="MSFYSNLPSAGQSSRGSSTSGRNGVGLEPLYPTIFEIMSSQEID
SLLPASIRYLLANHLVANFPNRYTLRLNKYFFEWFQAIKGFVEWYHLKTYNSTFIDRF
YGLQLFSSRDRNLALTQCLNPKGQSEWPQGLQLNQQQKSVIFLEKIILPYITAKLDEI
LEKISMNNIFSSDETENKWPKRAFLRIYPFIKKLLALSNLLVKLLFLTKRTGSVSLLQ
YLFKIEYTTVRPLSSELSGLKETKGMDNRLRKTNISSIFALMQGQLSIIPRFLTFMGS
QFFPTFIFVLRVYQWWTTQDMTTKLQKRVNDLDEDIPRPPFSSHSDKTEDKEGVSEAC
PVCEKTVQNPCVLETGYVACYPCAISYLVNNEGHCPVTNKKLLGCTYNKHTNKWEVVT
GIRKLLI"
gene <325877..>327289
/locus_tag="YMR027W"
/db_xref="GeneID:855042"
mRNA <325877..>327289
/locus_tag="YMR027W"
/product="putative methyltransferase"
/transcript_id="NM_001182523.1"
/db_xref="GeneID:855042"
CDS 325877..327289
/locus_tag="YMR027W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0016791 phosphatase
activity [PMID:27322068]"
/note="A metal-dependent phosphatase, part of the DUF89
protein family; dephosphorylates fructose-1-phosphate;
human ortholog, C6orf211 is involved in response to DNA
damage; green fluorescent protein (GFP)-fusion protein
localizes to the nucleus and cytoplasm; YMR027W is not an
essential gene"
/codon_start=1
/product="putative methyltransferase"
/protein_id="NP_013740.1"
/db_xref="GeneID:855042"
/db_xref="SGD:S000004629"
/translation="MTIPGRFMTIDKGTFGEYTASTRWPIIIQNAIDDLSKHQETEKS
NGTKFEQGEVIKKELKEFRQEIIDRVPLRPFTEEEIKIANVPLSFNEYLKKHPEVNWG
AVEWLFSEVYLYRRVNVLFQRQCEWAKFDIFNRLKQSTFESSFYGVVELALRYENLLP
QLREMKQNPGNEIDDILKVLFKEFIEISLWGNATDLSLLTNATLEDIKSIQGAKARAA
SESKIVVNDTEKAWEVLTKARADANSREIRVDFVLDNSGFELYADLMLAAFLLQSGLA
TKCIFHAKDIPYMVSDVMLKDFDILVHDLRDREFFPSGEPSTKESRALDLFAGEMEKF
VSSGKIEFREDSFWTTELDYWNLDANETKYHGSILHKDLQKSNLVIFKGDLNYRKLTG
DRKWPRTTKWETAIGPLATNGITSLSLRTCKADVQVALPEGLDAKLSQEWEKENPGRG
SWWCCSGKWAVICFCSGIHK"
gene <327482..>328582
/gene="TAP42"
/locus_tag="YMR028W"
/db_xref="GeneID:855043"
mRNA <327482..>328582
/gene="TAP42"
/locus_tag="YMR028W"
/product="Tap42p"
/transcript_id="NM_001182524.1"
/db_xref="GeneID:855043"
CDS 327482..328582
/gene="TAP42"
/locus_tag="YMR028W"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:16874307]"
/experiment="EXISTENCE:genetic interaction:GO:0045943
positive regulation of transcription by RNA polymerase I
[PMID:19684113]"
/experiment="EXISTENCE:genetic interaction:GO:1903432
regulation of TORC1 signaling
[PMID:10329624|PMID:14551259]"
/experiment="EXISTENCE:mutant phenotype:GO:0045943
positive regulation of transcription by RNA polymerase I
[PMID:19684113]"
/experiment="EXISTENCE:mutant phenotype:GO:1903432
regulation of TORC1 signaling
[PMID:10604478|PMID:12820961]"
/note="Essential protein involved in the TOR signaling
pathway; physically associates with the protein
phosphatase 2A and the SIT4 protein phosphatase catalytic
subunits"
/codon_start=1
/product="Tap42p"
/protein_id="NP_013741.1"
/db_xref="GeneID:855043"
/db_xref="SGD:S000004630"
/translation="MASVTEQFNDIISLYSTKLEHTSLRQDSPEYQGLLLSTIKKLLN
LKTAIFDRLALFSTNETIDDVSTASIKFLAVDYYLGLLISRRQSNDSDVAQRQSMKLI
YLKKSVESFINFLTLLQDYKLLDPLVGEKLGNFKDRYNPQLSELYAQPKNNKDLSGAQ
LKRKEKIELFQRNKEISTKLHCLELELKNNDEDHDHDELLRELYLMRLHHFSLDTINN
IEQNLFECEMLSNFLKNSVHEVKSSGTQIRKESNDDDSTGFTDKLENINKPLIDKKGQ
VLRNFTLVDKRQQLQQKVRGYGQYGPTMSVEEFLDKEFEEGRVLQGGEEPEQAPDEEN
MDWQDRETYKAREWDEFKESHAKGSGNTMNRG"
gene complement(<328660..>330231)
/gene="FAR8"
/locus_tag="YMR029C"
/db_xref="GeneID:855044"
mRNA complement(<328660..>330231)
/gene="FAR8"
/locus_tag="YMR029C"
/product="Far8p"
/transcript_id="NM_001182525.1"
/db_xref="GeneID:855044"
CDS complement(328660..330231)
/gene="FAR8"
/locus_tag="YMR029C"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:23625923]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0000321
re-entry into mitotic cell cycle after pheromone arrest
[PMID:12588993]"
/note="Protein involved in recovery from arrest in
response to pheromone; acts in a cell cycle arrest
recovery pathway independent from Far1p; interacts with
Far3p, Far7p, Far9p, Far10p, and Far11p"
/codon_start=1
/product="Far8p"
/protein_id="NP_013742.1"
/db_xref="GeneID:855044"
/db_xref="SGD:S000004631"
/translation="MAINQAHVHPHYTLPGVMHYLQTEFTKNERDRITWELERSEMKA
RIAELEGENRDLKHQLNQIQSKAVSPEGEKEEKHVPDSLLQSKLAVQENVKEIIYLLK
GPNTVNQLESLNSREAGSELHDLEKLNVNTPKEEGSAKTNGMDILNNALLDTKPNPKQ
GPSESPSPTKVKSLFSTANKRENNETISKIHSELSKVDIISSYGDCMALYDADTKSLE
IHQVDANLNSKLLKKISLGQDSDIMKFFWVSTSKLLVIEKSFHLKLFSISSASLISDV
DLLQDSEQPFSSSDIINIDFKNKWLLIASKNKSQIRIWELDNIEAPEDVPINIKETYE
ITHDNDDDDSNDSTNILDCILGITEKSLILLSSNPYQLTIYDFEGKLLQKIDLKIDTI
LSGKPEEEGYHLFLDRKTSKLLIQLSNERLLVYSFDKKKVVLKEQLTPSSTLPIQLDL
NDSIITVSYSNGDFEFRNLENLKPSIDEFVVADINFSERKEPVVFSSNLIVDSTPVLI
TVNKNNEVLLHKIKI"
gene <330793..>331923
/gene="RSF1"
/locus_tag="YMR030W"
/db_xref="GeneID:855045"
mRNA <330793..>331923
/gene="RSF1"
/locus_tag="YMR030W"
/product="Rsf1p"
/transcript_id="NM_001182526.1"
/db_xref="GeneID:855045"
CDS 330793..331923
/gene="RSF1"
/locus_tag="YMR030W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:12734673]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:12734673]"
/experiment="EXISTENCE:mutant phenotype:GO:0006366
transcription by RNA polymerase II [PMID:12734673]"
/experiment="EXISTENCE:mutant phenotype:GO:0006390
mitochondrial transcription [PMID:12734673]"
/experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
respiration [PMID:12734673]"
/note="Protein required for respiratory growth; localized
to both the nucleus and mitochondrion; may interact with
transcription factors to mediate the transition to
respiratory growth and activate transcription of nuclear
and mitochondrial genes"
/codon_start=1
/product="Rsf1p"
/protein_id="NP_013743.1"
/db_xref="GeneID:855045"
/db_xref="SGD:S000004632"
/translation="MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREE
MYLAPNKMETPRILNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIE
SNSTKDSKYAVQRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPKRRDIKGNH
LSKLLFAKSPLTINTYCQFYDRRTKRICNQEMIWKDKNSREKHGSRKYQRHLSKVHDV
QLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPET
GSSLINHQVQQQNVRELQSKIAMNDLIEILIDLNIPFSVLDYQPMRNWLIKYSIISTD
TLPDEVYFKTDPGVNELEHNSSNLNNSNSGTPHNHNQNQHTN"
gene complement(<332212..>334743)
/gene="EIS1"
/locus_tag="YMR031C"
/db_xref="GeneID:855047"
mRNA complement(<332212..>334743)
/gene="EIS1"
/locus_tag="YMR031C"
/product="Eis1p"
/transcript_id="NM_001182527.1"
/db_xref="GeneID:855047"
CDS complement(332212..334743)
/gene="EIS1"
/locus_tag="YMR031C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0032126 eisosome
[PMID:19064668|PMID:19269952|PMID:20526336]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0032126
eisosome [PMID:20526336]"
/experiment="EXISTENCE:mutant phenotype:GO:0070941
eisosome assembly [PMID:20526336]"
/note="Component of the eisosome required for proper
eisosome assembly; similar to Uso1p; authentic, non-tagged
protein is detected in a phosphorylated state in highly
purified mitochondria in high-throughput studies; protein
increases in abundance and relocalizes from plasma
membrane to cytoplasm upon DNA replication stress; EIS1
has a paralog, YKL050C, that arose from the whole genome
duplication"
/codon_start=1
/product="Eis1p"
/protein_id="NP_013744.1"
/db_xref="GeneID:855047"
/db_xref="SGD:S000004633"
/translation="MSLISAVEDRDIHNIGKTSGGGSRTSSITSSKKSLKHGSKSLRK
PKVYQTTGEPLSREALYKAKLKYGVYQSPAQSYSIGVSDAHAASDKAANLAHDNQTTV
EAYKRMFIDPNATKAASKMGPKVVRNNSITSATSKTSKESQTKRKSKESPGAAASKAY
SMTMETTSLSSQTNSRSYSITSASSVLSGASGSFNSTVNPKPKTLNLEKVLVGAEKKA
ESRIKERWEPEKTNFQYGVKTDEHGNLNQFSFSNEMMNNIMAKVDAPKAQDLQKVKKV
SAEKEAKSMKFALGAANAVKDMHPGEDIDKSIALKAQKRETYLSQLTSQQVLTLARAN
VDRQLDIIEKSDMHRKLFTNMEYNKAAVAVAQSNHQKKTEFHNKINMGGGLFLSPEDI
TKIASGLISPVLGEVSERAEAQRAMDEEIAERTEAYNKSSNEWETMERSIISNDAKVL
TTTANRHQTEKKTSQEKIKASFDALVARMDTKVAERETLLEDTKSKEIEFKKQMQQEL
KDEKARLDQDLEEWGKKCEQDITEARKEQEELLKPYHDDLANAEAEHKTLVEERDEIN
AEISRLQDAIVDHKRKISGYGNDLDAQKNRNIREDDKLLELGQTKESLESHLNDDVII
LANKAKEQAELSTKEARLKQLEVDSLINERKSELNATEIELKKEKLNLLEAMKDVASA
RGDDKIDEEKVKKLIGMTSEEYLTQNKSVEKNVEDLPTQLEKIEEGDELKKEEIVGAE
TKNSGGDGVPVSTAAKEATETSSAVQTKEPEEKISIGNKSSGKEDANDCKSAEHSKEI
SVSQKAGNNKSLGVSPDSLEHTFSGFSQGSSIEDDQDAISNQEKK"
gene <335298..>337307
/gene="HOF1"
/locus_tag="YMR032W"
/gene_synonym="CYK2"
/db_xref="GeneID:855048"
mRNA <335298..>337307
/gene="HOF1"
/locus_tag="YMR032W"
/gene_synonym="CYK2"
/product="formin-binding protein HOF1"
/transcript_id="NM_001182529.1"
/db_xref="GeneID:855048"
CDS 335298..337307
/gene="HOF1"
/locus_tag="YMR032W"
/gene_synonym="CYK2"
/experiment="EXISTENCE:direct assay:GO:0000142 cellular
bud neck contractile ring
[PMID:15775961|PMID:21498574|PMID:23468521|PMID:24451263|P
MID:9864366]"
/experiment="EXISTENCE:direct assay:GO:0000144 cellular
bud neck septin ring
[PMID:21498574|PMID:23468521|PMID:24451263|PMID:9864366]"
/experiment="EXISTENCE:direct assay:GO:0005543
phospholipid binding [PMID:25620000]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:23468521|PMID:27385335]"
/experiment="EXISTENCE:direct assay:GO:0005938 cell cortex
[PMID:23468521]"
/experiment="EXISTENCE:direct assay:GO:0008092
cytoskeletal protein binding [PMID:18344988|PMID:9774458]"
/experiment="EXISTENCE:direct assay:GO:0030427 site of
polarized growth [PMID:23468521]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:23468521]"
/experiment="EXISTENCE:direct assay:GO:0051015 actin
filament binding [PMID:32579428]"
/experiment="EXISTENCE:direct assay:GO:0051017 actin
filament bundle assembly [PMID:32579428]"
/experiment="EXISTENCE:direct assay:GO:0051126 negative
regulation of actin nucleation [PMID:30076201]"
/experiment="EXISTENCE:direct assay:GO:0120155 MIH complex
[PMID:24895401]"
/experiment="EXISTENCE:genetic interaction:GO:0000281
mitotic cytokinesis [PMID:22623719]"
/experiment="EXISTENCE:genetic interaction:GO:0072741
protein localization to cell division site
[PMID:23469085]"
/experiment="EXISTENCE:genetic interaction:GO:0090339
negative regulation of formin-nucleated actin cable
assembly [PMID:24719456]"
/experiment="EXISTENCE:genetic interaction:GO:1903475
mitotic actomyosin contractile ring assembly
[PMID:23469085]"
/experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic
cytokinesis [PMID:9774458]"
/experiment="EXISTENCE:mutant phenotype:GO:0031671 primary
cell septum biogenesis [PMID:29321253|PMID:21498574]"
/experiment="EXISTENCE:mutant phenotype:GO:0090339
negative regulation of formin-nucleated actin cable
assembly [PMID:24719456]"
/experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic
actomyosin contractile ring contraction [PMID:9864366]"
/experiment="EXISTENCE:mutant phenotype:GO:1903471
regulation of mitotic actomyosin contractile ring
contraction [PMID:24895401|PMID:21498574|PMID:23468521]"
/experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic
actomyosin contractile ring assembly [PMID:23469085]"
/experiment="EXISTENCE:physical interaction:GO:0032038
myosin II heavy chain binding [PMID:23468521]"
/experiment="EXISTENCE:physical interaction:GO:0044697
HICS complex [PMID:22623719]"
/experiment="EXISTENCE:physical interaction:GO:0120155 MIH
complex [PMID:24413167|PMID:24895401]"
/note="F-BAR protein that regulates actin cytoskeleton
organization; binds and bundles actin filaments, linking
them to septins; required for cytokinesis, actin cable
organization, and secretory vesicle trafficking; regulates
actomyosin ring dynamics and septin localization; N-term.
half controls cell size and actin cable levels, while the
C-term. half controls actin cable organization, inhibiting
Bnr1p-mediated actin nucleation; forms axial
striations/pillars at the bud neck; phosphorylated by
Dbf2p"
/codon_start=1
/product="formin-binding protein HOF1"
/protein_id="NP_013746.1"
/db_xref="GeneID:855048"
/db_xref="SGD:S000004635"
/translation="MSYSYEACFWDPNDNGVNILLGHISQGIRSCDSMILFFKQRSEL
EKDYARRLGAITGKLDKDIGTNMDYGKLNETFNVVLSVEKARAQSHSKQSEILFRQIY
TDTKAFAANLQARYTTLSGKIERLRMDKFNKKKGCEVLQKKLQDAQIRFRDLQLNENN
MIGAKRVEHNKRELLKWESNSQEYKVQLDVLKQEYKASQKFWIHEWAQLSCELQEMEN
ARISFLQSKLQQFATSSMETYILEQTKMDMLTNHLNSFTAADEISTFSKENGTGRLKH
KTSKGDMNSSANWAQMSSISTTSKKTESYMDNIRKLSSQLKETENKRKLASIDKYEKP
LPSPEVTMATQFRNSTPVIRNETKVVANPTLSLRSSPVQLQSNVDDSVLRQKPDKPRP
IVGEEQLKPDEDSKNPDEKGLMVHKRNQSLSSPSESSSSNPTDFSHIKKRQSMESMTT
SVSSMANSIDDSQRFAKSWNSSNRKRKSMSHLQVPSSASSRSDDGGRTPNSAHNLNED
DYNTRRDTSTSTILFKPPVAVRGTSRGHTHRQSMIMQDSSNPIEDALYEMERIQSSSK
PGTKTGNIMDERGVVRDRGITVTLPIVTSEGFPVIEYAKAMYPLIGNEAPGLANFHKG
DYLLITEIVNKDWYKGEVYDNDRIDRNHRIGLIPYNFIQLLHQGL"
gene <337313..>337603
/locus_tag="YMR030W-A"
/db_xref="GeneID:1466499"
mRNA <337313..>337603
/locus_tag="YMR030W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184572.1"
/db_xref="GeneID:1466499"
CDS 337313..337603
/locus_tag="YMR030W-A"
/note="hypothetical protein; mCherry fusion protein
localizes to the cytosol"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878141.1"
/db_xref="GeneID:1466499"
/db_xref="SGD:S000028574"
/translation="MYINFTSFLIKEKKYNVRFLLSRNRKIYAAVGEGHLSGFVTKNH
KISRLSFIFSKKKKVFFTIFDTIITIIVRSGIPFPLLCSFGRNKIYILFNVL"
gene <337788..>339277
/gene="ARP9"
/locus_tag="YMR033W"
/gene_synonym="RSC12; SWP59"
/db_xref="GeneID:855049"
mRNA join(<337788..337817,337904..>339277)
/gene="ARP9"
/locus_tag="YMR033W"
/gene_synonym="RSC12; SWP59"
/product="Arp9p"
/transcript_id="NM_001182530.1"
/db_xref="GeneID:855049"
CDS join(337788..337817,337904..339277)
/gene="ARP9"
/locus_tag="YMR033W"
/gene_synonym="RSC12; SWP59"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11011149]"
/experiment="EXISTENCE:direct assay:GO:0006337 nucleosome
disassembly [PMID:16492771]"
/experiment="EXISTENCE:direct assay:GO:0006338 chromatin
remodeling [PMID:12183366]"
/experiment="EXISTENCE:direct assay:GO:0006368
transcription elongation by RNA polymerase II
[PMID:17081996]"
/experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF
complex [PMID:18644858|PMID:8127913|PMID:9726966]"
/experiment="EXISTENCE:direct assay:GO:0016586 RSC-type
complex [PMID:10619019|PMID:12183366]"
/experiment="EXISTENCE:mutant phenotype:GO:0005198
structural molecule activity [PMID:12183366]"
/experiment="EXISTENCE:mutant phenotype:GO:0006338
chromatin remodeling [PMID:12183366]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:9726966]"
/note="Component of both the SWI/SNF and RSC chromatin
remodeling complexes; actin-related protein involved in
transcriptional regulation"
/codon_start=1
/product="Arp9p"
/protein_id="NP_013747.1"
/db_xref="GeneID:855049"
/db_xref="SGD:S000004636"
/translation="MAPFRQDSILIIYPRSQTTLVQFGLNEETFTVPELEIPTQIYRT
TRQDGSYTYHSTNKDNKAELIKPIQNGEIIDISAFTQFLRLIFVSILSDRANKNQDAF
EAELSNIPLLLITHHSWSQSDLEIITQYVFESLEINNLIQLPASLAATYSMISLQNCC
IIDVGTHHTDIIPIVDYAQLDHLVSSIPMGGQSINDSLKKLLPQWDDDQIESLKKSPI
FEVLSDDAKKLSSFDFGNENEDEDEGTLNVAEIITSGRDTREVLEERERGQKVKNVKN
SDLEFNTFWDEKGNEIKVGKQRFQGCNNLIKNISNRVGLTLDNIDDINKAKAVWENII
IVGGTTSISGFKEALLGQLLKDHLIIEPEEEKSKREEEAKSVLPAATKKKSKFMTNST
AFVPTIEYVQCPTVIKLAKYPDYFPEWKKSGYSEIIFLGAQIVSKQIFTHPKDTFYIT
REKYNMKGPAALWDVQF"
gene complement(<339418..>340722)
/gene="RCH1"
/locus_tag="YMR034C"
/db_xref="GeneID:855050"
mRNA complement(<339418..>340722)
/gene="RCH1"
/locus_tag="YMR034C"
/product="Rch1p"
/transcript_id="NM_001182531.1"
/db_xref="GeneID:855050"
CDS complement(339418..340722)
/gene="RCH1"
/locus_tag="YMR034C"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:26832117]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:26832117]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0051481
negative regulation of cytosolic calcium ion concentration
[PMID:26832117]"
/note="Negative regulator of cytosolic calcium
homeostasis; localizes to the plasma membrane,
concentrating at the bud neck during cell division;
regulated by Crz1p through a CDRE promoter element;
non-essential gene; putative transporter with sequence
similarity to human SLC10A7; functional homolog of C.
albicans RCH1"
/codon_start=1
/product="Rch1p"
/protein_id="NP_013748.1"
/db_xref="GeneID:855050"
/db_xref="SGD:S000004637"
/translation="MKTQYSLIRKIWAHSVTEFLKSQWFFICLAILIVIARFAPNFAR
DGGLIKGQYSIGYGCVAWIFLQSGLGMKSRSLMANMLNWRAHATILVLSFLITSSIVY
GFCCAVKAANDPKIDDWVLIGLILTATCPTTVASNVIMTTNAGGNSLLCVCEVFIGNL
LGAFITPALVQMFTNRAPFAYGNPATGNGIGALYGRVMKQVGLSVFVPLFVGQVIQNC
FPKGTAYYLGFLKKYHIKIGSYMLLLIMFSSFSTAFYQDAFTSVSHVCIIFLCFFNLG
IYIFFTGLSYLCARPWFILKLFPHEPIEGKSTRLYRYSYNIFRPFYYSKEDAICIMFC
GPAKTAALGVSLITSQYGDKKEHLGKLLVPLVLYQVEQVMTANFFVSLFKRWIQKDAQ
ADGSESSCANENEEVDLEKIISIGTGENQSVLSNNVPYTQPR"
gene <341142..>341675
/gene="IMP2"
/locus_tag="YMR035W"
/db_xref="GeneID:855051"
mRNA <341142..>341675
/gene="IMP2"
/locus_tag="YMR035W"
/product="endopeptidase catalytic subunit"
/transcript_id="NM_001182532.1"
/db_xref="GeneID:855051"
CDS 341142..341675
/gene="IMP2"
/locus_tag="YMR035W"
/experiment="EXISTENCE:direct assay:GO:0004175
endopeptidase activity [PMID:8132591]"
/experiment="EXISTENCE:mutant phenotype:GO:0004175
endopeptidase activity [PMID:8266095]"
/experiment="EXISTENCE:mutant phenotype:GO:0006627 protein
processing involved in protein targeting to mitochondrion
[PMID:8266095]"
/experiment="EXISTENCE:physical interaction:GO:0042720
mitochondrial inner membrane peptidase complex
[PMID:8132591|PMID:8266095]"
/note="Catalytic subunit of mitochondrial inner membrane
peptidase complex; required for maturation of
mitochondrial proteins of the intermembrane space; complex
contains two catalytic subunits (Imp1p and Imp2p that
differ in substrate specificity), and Som1p"
/codon_start=1
/product="endopeptidase catalytic subunit"
/protein_id="NP_013749.1"
/db_xref="GeneID:855051"
/db_xref="SGD:S000004638"
/translation="MFRAGSSKRFLRNTLIAISWVPVLLTINNNVVHIAQVKGTSMQP
TLNPQTETLATDWVLLWKFGVKNPSNLSRDDIILFKAPTNPRKVYCKRVKGLPFDTID
TKFPYPKPQVNLPRGHIWVEGDNYFHSIDSNTFGPISSGLVIGKAITIVWPPSRWGTD
LKLSTGRDCISKRAILE"
gene complement(<341856..>343520)
/gene="MIH1"
/locus_tag="YMR036C"
/db_xref="GeneID:855052"
mRNA complement(<341856..>343520)
/gene="MIH1"
/locus_tag="YMR036C"
/product="putative tyrosine protein phosphatase MIH1"
/transcript_id="NM_001182533.1"
/db_xref="GeneID:855052"
CDS complement(341856..343520)
/gene="MIH1"
/locus_tag="YMR036C"
/EC_number="3.1.3.48"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M
transition of mitotic cell cycle [PMID:2649252]"
/experiment="EXISTENCE:mutant phenotype:GO:0051231 spindle
elongation [PMID:30072442]"
/note="Protein tyrosine phosphatase; involved in cell
cycle control and retrograde protein transport; regulates
the phosphorylation state of Cdc28p; modulates
phosphorylation of retromer component Vps26p; homolog of
S. pombe cdc25"
/codon_start=1
/product="putative tyrosine protein phosphatase MIH1"
/protein_id="NP_013750.1"
/db_xref="GeneID:855052"
/db_xref="SGD:S000004639"
/translation="MNNIFHGTEDECANEDVLSFQKISLKSPFGKKKNIFRNVQTFFK
SKSKHSNVDDDLINKENLAFDKSPLLTNHRSKEIDGPSPNIKQLGHRDELDENENEND
DIVLSMHFASQTLQSPTRNSSRRSLTNNRDNDLLSRIKYPGSPQRSSSFSRSRSLSRK
PSMNSSSNSSRRVQRQDGKIPRSSRKSSQKFSNITQNTLNFTSASSSPLAPNSVGVKC
FESCLAKTQIPYYYDDRNSNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEY
TGGHIINSVNIHSRDELEYEFIHKVLHSDTSNNNTLPTLLIIHCEFSSHRGPSLASHL
RNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGMNSQENLLNCEQE
MDKFRRESKRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLSL
NHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSFED
ERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK"
gene complement(<344403..>346517)
/gene="MSN2"
/locus_tag="YMR037C"
/db_xref="GeneID:855053"
mRNA complement(<344403..>346517)
/gene="MSN2"
/locus_tag="YMR037C"
/product="stress-responsive transcriptional activator
MSN2"
/transcript_id="NM_001182534.1"
/db_xref="GeneID:855053"
CDS complement(344403..346517)
/gene="MSN2"
/locus_tag="YMR037C"
/experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding
transcription factor activity, RNA polymerase II-specific
[PMID:23435728|PMID:8650168]"
/experiment="EXISTENCE:direct assay:GO:0000987
cis-regulatory region sequence-specific DNA binding
[PMID:8321194|PMID:8641288|PMID:8650168]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:12093809|PMID:12732613|PMID:22842922|PMID:9472026]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:12093809|PMID:12732613|PMID:9472026]"
/experiment="EXISTENCE:genetic interaction:GO:0006338
chromatin remodeling [PMID:18070923]"
/experiment="EXISTENCE:genetic interaction:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:17914901]"
/experiment="EXISTENCE:genetic interaction:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:20398213|PMID:27637775|PMID:19702872|PMID:17914901|P
MID:8641288|PMID:11102521|PMID:11179418|PMID:15053871|PMID
:15483057|PMID:15922872|PMID:16710843|PMID:17055490|PMID:1
9073887|PMID:21749328|PMID:26947009|PMID:10652100|PMID:171
50183]"
/experiment="EXISTENCE:mutant phenotype:GO:0000981
DNA-binding transcription factor activity, RNA polymerase
II-specific [PMID:8650168]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:11102521|PMID:15922872|PMID:16980434|PMID:8650168]"
/note="Stress-responsive transcriptional activator;
activated in stochastic pulses of nuclear localization in
response to various stress conditions; binds DNA at stress
response elements of responsive genes; light sensing
pathway component that accumulates in the nucleus in
response to blue light; relative distribution to nucleus
increases upon DNA replication stress"
/codon_start=1
/product="stress-responsive transcriptional activator
MSN2"
/protein_id="NP_013751.1"
/db_xref="GeneID:855053"
/db_xref="SGD:S000004640"
/translation="MTVDHDFNSEDILFPIESMSSIQYVENNNPNNINNDVIPYSLDI
KNTVLDSADLNDIQNQETSLNLGLPPLSFDSPLPVTETIPSTTDNSLHLKADSNKNRD
ARTIENDSEIKSTNNASGSGANQYTTLTSPYPMNDILYNMNNPLQSPSPSSVPQNPTI
NPPINTASNETNLSPQTSNGNETLISPRAQQHTSIKDNRLSLPNGANSNLFIDTNPNN
LNEKLRNQLNSDTNSYSNSISNSNSNSTGNLNSSYFNSLNIDSMLDDYVSSDLLLNDD
DDDTNLSRRRFSDVITNQFPSMTNSRNSISHSLDLWNHPKINPSNRNTNLNITTNSTS
SSNASPNTTTMNANADSNIAGNPKNNDATIDNELTQILNEYNMNFNDNLGTSTSGKNK
SACPSSFDANAMTKINPSQQLQQQLNRVQHKQLTSSHNNSSTNMKSFNSDLYSRRQRA
SLPIIDDSLSYDLVNKQDEDPKNDMLPNSNLSSSQQFIKPSMILSDNASVIAKVATTG
LSNDMPFLTEEGEQNANSTPNFDLSITQMNMAPLSPASSSSTSLATNHFYHHFPQQGH
HTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVTKERRPSYRRK
SMTPSRRSSVVIESTKELEEKPFHCHICPKSFKRSEHLKRHVRSVHSNERPFACHICD
KKFSRSDNLSQHIKTHKKHGDI"
gene complement(<347511..>348260)
/gene="CCS1"
/locus_tag="YMR038C"
/gene_synonym="LYS7"
/db_xref="GeneID:855054"
mRNA complement(<347511..>348260)
/gene="CCS1"
/locus_tag="YMR038C"
/gene_synonym="LYS7"
/product="copper chaperone CCS1"
/transcript_id="NM_001182535.1"
/db_xref="GeneID:855054"
CDS complement(347511..348260)
/gene="CCS1"
/locus_tag="YMR038C"
/gene_synonym="LYS7"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:18977757]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:11500508]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:9295278]"
/experiment="EXISTENCE:genetic interaction:GO:0016532
superoxide dismutase copper chaperone activity
[PMID:9295278]"
/experiment="EXISTENCE:mutant phenotype:GO:0015680 protein
maturation by copper ion transfer [PMID:9295278]"
/experiment="EXISTENCE:mutant phenotype:GO:0016532
superoxide dismutase copper chaperone activity
[PMID:9295278]"
/note="Copper chaperone for superoxide dismutase Sod1p;
involved in oxidative stress protection; Met-X-Cys-X2-Cys
motif within N-terminus is involved in insertion of copper
into Sod1p under conditions of copper deprivation;
required for regulation of yeast copper genes in response
to DNA-damaging agents; protein abundance increases in
response to DNA replication stress; human homolog CCS can
complement yeast ccs1 null mutant"
/codon_start=1
/product="copper chaperone CCS1"
/protein_id="NP_013752.1"
/db_xref="GeneID:855054"
/db_xref="SGD:S000004641"
/translation="MTTNDTYEATYAIPMHCENCVNDIKACLKNVPGINSLNFDIEQQ
IMSVESSVAPSTIINTLRNCGKDAIIRGAGKPNSSAVAILETFQKYTIDQKKDTAVRG
LARIVQVGENKTLFDITVNGVPEAGNYHASIHEKGDVSKGVESTGKVWHKFDEPIECF
NESDLGKNLYSGKTFLSAPLPTWQLIGRSFVISKSLNHPENEPSSVKDYSFLGVIARS
AGVWENNKQVCACTGKTVWEERKDALANNIK"
gene complement(<348644..>349522)
/gene="SUB1"
/locus_tag="YMR039C"
/gene_synonym="TSP1"
/db_xref="GeneID:855055"
mRNA complement(<348644..>349522)
/gene="SUB1"
/locus_tag="YMR039C"
/gene_synonym="TSP1"
/product="chromatin-binding transcription coactivator
SUB1"
/transcript_id="NM_001182536.1"
/db_xref="GeneID:855055"
CDS complement(348644..349522)
/gene="SUB1"
/locus_tag="YMR039C"
/gene_synonym="TSP1"
/experiment="EXISTENCE:direct assay:GO:0003682 chromatin
binding [PMID:26147804]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:26147804]"
/experiment="EXISTENCE:direct assay:GO:0006357 regulation
of transcription by RNA polymerase II [PMID:19204085]"
/experiment="EXISTENCE:direct assay:GO:0045945 positive
regulation of transcription by RNA polymerase III
[PMID:19204085|PMID:19706510]"
/experiment="EXISTENCE:direct assay:GO:0051880
G-quadruplex DNA binding [PMID:25813861]"
/experiment="EXISTENCE:direct assay:GO:0070898 RNA
polymerase III preinitiation complex assembly
[PMID:19706510]"
/experiment="EXISTENCE:genetic interaction:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:19204085]"
/experiment="EXISTENCE:genetic interaction:GO:0006369
termination of RNA polymerase II transcription
[PMID:11389848]"
/experiment="EXISTENCE:genetic interaction:GO:0006972
hyperosmotic response [PMID:19204085]"
/experiment="EXISTENCE:genetic interaction:GO:0045945
positive regulation of transcription by RNA polymerase III
[PMID:19204085]"
/experiment="EXISTENCE:mutant phenotype:GO:0006303
double-strand break repair via nonhomologous end joining
[PMID:23554872]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:19204085]"
/experiment="EXISTENCE:mutant phenotype:GO:0032968
positive regulation of transcription elongation by RNA
polymerase II [PMID:15692559]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:26837954]"
/experiment="EXISTENCE:mutant phenotype:GO:0045945
positive regulation of transcription by RNA polymerase III
[PMID:19204085|PMID:19706510]"
/experiment="EXISTENCE:mutant phenotype:GO:0075297
negative regulation of ascospore formation
[PMID:26147804]"
/note="Transcriptional regulator; facilitates elongation
through factors that modify RNAP II; role in peroxide
resistance involving Rad2p; role in nonhomologous
end-joining (NHEJ) of ds breaks in plasmid DNA, but not
chromosomal DNA; role in the hyperosmotic stress response
through polymerase recruitment at RNAP II and RNAP III
genes; negatively regulates sporulation; protein abundance
increases in response to DNA replication stress;
functionally complemented by human SUB1 (PC4)"
/codon_start=1
/product="chromatin-binding transcription coactivator
SUB1"
/protein_id="NP_013753.1"
/db_xref="GeneID:855055"
/db_xref="SGD:S000004642"
/translation="MSYYNRYRNKRRSDNGGGNLSNSNNNNGGMPSGLSASDAIFDLG
KNKRVTVRQFRNINLIDIREYYLDSSTGEMKPGKKGISLTEDLYDELLKHRLNIDEAL
RRLGSKRPKTKMVRLLSDDEYEDDNNNDSTNNDKDKNGKDKNSPKKRREDKSKASNES
HDLEPRSKKKKPAPPTLLPHEENIQNAEREANATLIIPGQAGRKQQEERKQKEKEEAE
EAKAKAVAEQEKEAKAKEKIAEPEPEPVPTLQAKKEDIVSNINESKDANSSDEEFAQS
LEAEMNKAEDDISEEE"
gene <350381..>350863
/gene="YET2"
/locus_tag="YMR040W"
/db_xref="GeneID:855056"
mRNA <350381..>350863
/gene="YET2"
/locus_tag="YMR040W"
/product="Yet2p"
/transcript_id="NM_001182537.1"
/db_xref="GeneID:855056"
CDS 350381..350863
/gene="YET2"
/locus_tag="YMR040W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/note="hypothetical protein that may interact with
ribosomes; based on co-purification experiments; homolog
of human BAP31 protein; YET2 has a paralog, YET1, that
arose from the whole genome duplication"
/codon_start=1
/product="Yet2p"
/protein_id="NP_013754.1"
/db_xref="GeneID:855056"
/db_xref="SGD:S000004643"
/translation="MGVYLAVLFSLLVIEMAILFILVLPLPQRMRRWLYIRYSIISTN
KKFRTYMVGIMIFVGLLFIDSWKRSQIRVSTYRNQKNPYIINSVTPVDALASRAYNQR
NVYISGFIIYFYICILTVMSILRRIVEWNDKMKAGDDILKEKLRRKQKYLEELQKKKF
"
gene complement(<350966..>351973)
/gene="ARA2"
/locus_tag="YMR041C"
/db_xref="GeneID:855057"
mRNA complement(<350966..>351973)
/gene="ARA2"
/locus_tag="YMR041C"
/product="D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2"
/transcript_id="NM_001182538.1"
/db_xref="GeneID:855057"
CDS complement(350966..351973)
/gene="ARA2"
/locus_tag="YMR041C"
/EC_number="1.1.1.116"
/experiment="EXISTENCE:direct assay:GO:0045290 D-arabinose
1-dehydrogenase [NAD(P)+] activity [PMID:17097644]"
/experiment="EXISTENCE:mutant phenotype:GO:0045290
D-arabinose 1-dehydrogenase [NAD(P)+] activity
[PMID:17097644]"
/experiment="EXISTENCE:mutant phenotype:GO:0070485
dehydro-D-arabinono-1,4-lactone biosynthetic process
[PMID:17097644]"
/note="NAD-dependent arabinose dehydrogenase; involved in
biosynthesis of dehydro-D-arabinono-1,4-lactone; similar
to plant L-galactose dehydrogenase"
/codon_start=1
/product="D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2"
/protein_id="NP_013755.1"
/db_xref="GeneID:855057"
/db_xref="SGD:S000004644"
/translation="MVNEKVNPFDLASVSPLVLGGAILNQQYTDEPESIPLEDIIKYA
FSHGINAIDTSPYYGPSEVLYGRALSNLRNEFPRDTYFICTKVGRIGAEEFNYSRDFV
RFSVHRSCERLHTTYLDLVYLHDVEFVKFPDILEALKELRTLKNKGVIKNFGISGYPI
DFITWLAEYCSTEESDIGSLDAVLSYCNLNLQNNKLLNFRERLLRNAKLKMVCNASIL
SMSLLRSQETRQFHPCSHELRECASQAAKYCQEQNVDLADLATRYAISEWVGKGPVVL
GVSSMEELKLALDNYEIVKSNGNRLSSKDGQLVEYIQKNIFKEHFNEEWSSGIPHPEM
I"
gene 352280..352370
/locus_tag="YNCM0019W"
/db_xref="GeneID:855058"
tRNA join(352280..352316,352335..352370)
/locus_tag="YNCM0019W"
/product="tRNA-Phe"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:10024171]"
/note="Phenylalanine tRNA (tRNA-Phe), predicted by
tRNAscan-SE analysis"
/db_xref="GeneID:855058"
/db_xref="SGD:S000006568"
gene <352603..>353136
/gene="ARG80"
/locus_tag="YMR042W"
/gene_synonym="ARGR1"
/db_xref="GeneID:855059"
mRNA <352603..>353136
/gene="ARG80"
/locus_tag="YMR042W"
/gene_synonym="ARGR1"
/product="Arg80p"
/transcript_id="NM_001182539.1"
/db_xref="GeneID:855059"
CDS 352603..353136
/gene="ARG80"
/locus_tag="YMR042W"
/gene_synonym="ARGR1"
/experiment="EXISTENCE:direct assay:GO:0000987
cis-regulatory region sequence-specific DNA binding
[PMID:12138185]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762|PMID:3311884]"
/experiment="EXISTENCE:mutant phenotype:GO:0000987
cis-regulatory region sequence-specific DNA binding
[PMID:12138185]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:8212891]"
/experiment="EXISTENCE:mutant phenotype:GO:1900079
regulation of arginine biosynthetic process
[PMID:5434281]"
/experiment="EXISTENCE:mutant phenotype:GO:1900081
regulation of arginine catabolic process [PMID:12138185]"
/note="Transcription factor involved in regulating
arginine-responsive genes; acts with Arg81p and Arg82p"
/codon_start=1
/product="Arg80p"
/protein_id="NP_013756.1"
/db_xref="GeneID:855059"
/db_xref="SGD:S000004645"
/translation="MTSNSDGSSTSPVEKPITGDVETNEPTKPIRRLSTPSPEQDQEG
DFDEEDDDDKFSVSTSTPTPTITKTKDSSDTSTVTRRKQPIRYIENKTRRHVTFSKRR
HGIMKKAYELSVLTGANILLLILANSGLVYTFTTPKLEPVVREDEGKSLIRACINASD
TPDATDTSPAQEQSPAN"
gene <353871..>354731
/gene="MCM1"
/locus_tag="YMR043W"
/gene_synonym="FUN80"
/db_xref="GeneID:855060"
mRNA <353871..>354731
/gene="MCM1"
/locus_tag="YMR043W"
/gene_synonym="FUN80"
/product="transcription factor MCM1"
/transcript_id="NM_001182540.1"
/db_xref="GeneID:855060"
CDS 353871..354731
/gene="MCM1"
/locus_tag="YMR043W"
/gene_synonym="FUN80"
/experiment="EXISTENCE:direct assay:GO:0000122 negative
regulation of transcription by RNA polymerase II
[PMID:9121436]"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:12473677]"
/experiment="EXISTENCE:direct assay:GO:0000978 RNA
polymerase II cis-regulatory region sequence-specific DNA
binding [PMID:12738768|PMID:1752436|PMID:2673922]"
/experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding
transcription factor activity, RNA polymerase II-specific
[PMID:11562353]"
/experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding
transcription repressor activity, RNA polymerase
II-specific [PMID:9121436]"
/experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding
transcription activator activity, RNA polymerase
II-specific [PMID:12052870|PMID:9121436]"
/experiment="EXISTENCE:direct assay:GO:0003688 DNA
replication origin binding [PMID:12473677]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding [PMID:19158363]"
/experiment="EXISTENCE:direct assay:GO:0044377 RNA
polymerase II cis-regulatory region sequence-specific DNA
binding, bending
[PMID:12509445|PMID:7739902|PMID:9121436|PMID:9490409]"
/experiment="EXISTENCE:direct assay:GO:0045944 positive
regulation of transcription by RNA polymerase II
[PMID:19233144|PMID:9121436|PMID:11060038]"
/experiment="EXISTENCE:direct assay:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:9490409]"
/experiment="EXISTENCE:mutant phenotype:GO:0000122
negative regulation of transcription by RNA polymerase II
[PMID:8455631|PMID:16278448|PMID:1961765]"
/experiment="EXISTENCE:mutant phenotype:GO:0001228
DNA-binding transcription activator activity, RNA
polymerase II-specific [PMID:10594003]"
/experiment="EXISTENCE:mutant phenotype:GO:0031494
regulation of mating type switching [PMID:9620858]"
/experiment="EXISTENCE:mutant phenotype:GO:0044377 RNA
polymerase II cis-regulatory region sequence-specific DNA
binding, bending
[PMID:10594003|PMID:12509445|PMID:15118075]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:7565744|PMID:8455631|PMID:12738768|PMID:16278448|PMI
D:19233144|PMID:1961765|PMID:9171372]"
/experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:12052870|PMID:12711672]"
/experiment="EXISTENCE:physical interaction:GO:0000981
DNA-binding transcription factor activity, RNA polymerase
II-specific [PMID:19233144]"
/experiment="EXISTENCE:physical interaction:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:12509445|PMID:12711672]"
/note="Transcription factor; involved in
cell-type-specific transcription and pheromone response;
plays a central role in the formation of both repressor
and activator complexes; relocalizes to the cytosol in
response to hypoxia"
/codon_start=1
/product="transcription factor MCM1"
/protein_id="NP_013757.1"
/db_xref="GeneID:855060"
/db_xref="SGD:S000004646"
/translation="MSDIEEGTPTNNGQQKERRKIEIKFIENKTRRHVTFSKRKHGIM
KKAFELSVLTGTQVLLLVVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEE
DEEEDGDDDDDDDDDGNDMQRQQPQQQQPQQQQQVLNAHANSLGHLNQDQVPAGALKQ
EVKSQLLGGANPNQNSMIQQQQHHTQNSQPQQQQQQQPQQQMSQQQMSQHPRPQQGIP
HPQQSQPQQQQQQQQQLQQQQQQQQQQPLTGIHQPHQQAFANAASPYLNAEQNAAYQQ
YFQEPQQGQY"
gene <355384..>356811
/gene="IOC4"
/locus_tag="YMR044W"
/db_xref="GeneID:855061"
mRNA <355384..>356811
/gene="IOC4"
/locus_tag="YMR044W"
/product="Ioc4p"
/transcript_id="NM_001182541.1"
/db_xref="GeneID:855061"
CDS 355384..356811
/gene="IOC4"
/locus_tag="YMR044W"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:12482963]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:12482963]"
/experiment="EXISTENCE:direct assay:GO:0036437 Isw1b
complex [PMID:12482963]"
/experiment="EXISTENCE:mutant phenotype:GO:0007062 sister
chromatid cohesion [PMID:27185881]"
/experiment="EXISTENCE:physical interaction:GO:0006338
chromatin remodeling [PMID:12482963]"
/note="Member of a complex (Isw1b) with Isw1p and Ioc2p;
interacts directly with H3K36me3 nucleosomes through its
PWWP domain to recruit the Isw1b complex to open reading
frames in a Set2p-dependent manner; Isw1b exhibits
nucleosome-stimulated ATPase activity and acts within
coding regions to coordinate transcription elongation with
termination and processing"
/codon_start=1
/product="Ioc4p"
/protein_id="NP_013758.1"
/db_xref="GeneID:855061"
/db_xref="SGD:S000004647"
/translation="MSEAIFQPTDIVLAKVKGFSAWPAMIIPNELIPDNILKTKPVSV
HKGKSGSDKKANEDIDADMESEARDREQSEEEEDIEDFGESEANPEKFIIYTPVLKFR
KNDTLKSTYCVKFFCDDSYIWVKPMDMKILTSEDCRKWLSGKQRKNKKLIPAYEMAMR
GKNGIDIWEFVEYGSYGKPDEEEYVEEEEEENEPEKKAIRPTRSSSRQRQKRASETEK
SEGGNSNKRKRVTRSTRQQAIDASEEEEEEEEEKVQEAVRKRPQRTKTKKVVVSKTKP
NPKTKAKKEKPKPPKPIKYHFEDDEDWSIVGLGPQDLSIEKTMDPIAKKLSQKKNLEK
HVEIKLDLEDKLAGINKLLCDVLCSAINQAVSIKDDFEIILDELQIALDTRGSRNEFI
TIFQSNNSLLLNFRILFNLRKRELNKWDLWDRFQDIFKHIYSYQFIPDTEDWQLEQNM
EIEEMDREKPSFSEDVKEEESKVGA"
mobile_element complement(357005..362918)
/note="YMRCTy1-3; Ty1 element, LTR retrotransposon of the
Copia (Pseudoviridae) group; contains co-transcribed genes
TYA Gag and TYB Pol, encoding proteins involved in
structure and function of virus-like particles, flanked by
two direct repeats"
/mobile_element_type="retrotransposon:YMRCTy1-3"
/db_xref="SGD:S000007119"
repeat_region complement(357005..357336)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007109"
gene complement(<357359..>362627)
/locus_tag="YMR045C"
/db_xref="GeneID:855062"
mRNA complement(<357359..>362627)
/locus_tag="YMR045C"
/product="gag-pol fusion protein"
/transcript_id="NM_001182542.2"
/db_xref="GeneID:855062"
CDS complement(join(357359..361321,361323..362627))
/locus_tag="YMR045C"
/EC_number="2.7.7.7"
/EC_number="2.7.7.49"
/EC_number="3.1.26.4"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9448009]"
/ribosomal_slippage
/note="Retrotransposon TYA Gag and TYB Pol genes;
transcribed/translated as one unit; polyprotein is
processed to make a nucleocapsid-like protein (Gag),
reverse transcriptase (RT), protease (PR), and integrase
(IN); similar to retroviral genes"
/codon_start=1
/product="gag-pol fusion protein"
/protein_id="NP_013759.1"
/db_xref="GeneID:855062"
/db_xref="SGD:S000004648"
/translation="MESQQLSQHSPISHGSACASVTSKEVQTTQDPLDISASKTEECE
KVSTQANSQQPTTPLSSAVPENHHHASPQAAQVPLPQNGPYPQQRMMNTQQANISGWP
VYGHPSLMPYPPYQMSPMYAPPGAQSQFTQYPQYVGTHLNTPSPESGNSFPDSSSAKS
NMTSTNQHVRPPPILTSPNDFLNWVKIYIKFLQNSNLGDIIPTATRKAVRQMTDDELT
FLCHTFQLFAPSQFLPPWVKDILSVDYTDIMKILSKSINKMQSDTQEVNDITTLATLH
YNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRCIHM
TVADLFSDIHSMYEEQQESKRNKSTHRRSPSDEKKDSRTYTNTTKPKSITRNSQKPNN
SQSRTARAHNVSTFNNSPGPDNDLIRGSTTEPIQLKNTHDLHLGQELTESTVNHTNHS
DDKLPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD
NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV
SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE
SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS
APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE
YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS
AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI
PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT
ASYHSFIASNEIQQSNDLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTE
DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAP
MSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKR
IIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSD
SFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL
EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLL
KMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQS
NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK
KSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFENSQVTICLFVDDMVLFSKNL
NSNKRIIDKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP
KLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRF
DLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISD
ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSY
LIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCY
IETKKNIADVMTKPLPIKTFKLLTNKWIH"
gene complement(<361305..>362627)
/locus_tag="YMR046C"
/db_xref="GeneID:855063"
mRNA complement(<361305..>362627)
/locus_tag="YMR046C"
/product="gag protein"
/transcript_id="NM_001182543.1"
/db_xref="GeneID:855063"
CDS complement(361305..362627)
/locus_tag="YMR046C"
/note="Retrotransposon TYA Gag gene co-transcribed with
TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is
a nucleocapsid protein that is the structural constituent
of virus-like particles (VLPs); similar to retroviral Gag"
/codon_start=1
/product="gag protein"
/protein_id="NP_013760.1"
/db_xref="GeneID:855063"
/db_xref="SGD:S000004649"
/translation="MESQQLSQHSPISHGSACASVTSKEVQTTQDPLDISASKTEECE
KVSTQANSQQPTTPLSSAVPENHHHASPQAAQVPLPQNGPYPQQRMMNTQQANISGWP
VYGHPSLMPYPPYQMSPMYAPPGAQSQFTQYPQYVGTHLNTPSPESGNSFPDSSSAKS
NMTSTNQHVRPPPILTSPNDFLNWVKIYIKFLQNSNLGDIIPTATRKAVRQMTDDELT
FLCHTFQLFAPSQFLPPWVKDILSVDYTDIMKILSKSINKMQSDTQEVNDITTLATLH
YNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRCIHM
TVADLFSDIHSMYEEQQESKRNKSTHRRSPSDEKKDSRTYTNTTKPKSITRNSQKPNN
SQSRTARAHNVSTFNNSPGPDNDLIRGSTTEPIQLKNTHDLHLRPGTY"
repeat_region complement(362587..362918)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007110"
gene 363064..363135
/locus_tag="YNCM0020W"
/db_xref="GeneID:855065"
tRNA 363064..363135
/locus_tag="YNCM0020W"
/product="tRNA-His"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0030371 translation
repressor activity [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043555 regulation
of translation in response to stress [PMID:27609601]"
/note="Histidine tRNA (tRNA-His), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:855065"
/db_xref="SGD:S000006599"
gene complement(<363364..>366705)
/gene="NUP116"
/locus_tag="YMR047C"
/gene_synonym="NSP116"
/db_xref="GeneID:855066"
mRNA complement(<363364..>366705)
/gene="NUP116"
/locus_tag="YMR047C"
/gene_synonym="NSP116"
/product="FG-nucleoporin NUP116"
/transcript_id="NM_001182544.1"
/db_xref="GeneID:855066"
CDS complement(363364..366705)
/gene="NUP116"
/locus_tag="YMR047C"
/gene_synonym="NSP116"
/experiment="EXISTENCE:direct assay:GO:0005643 nuclear
pore [PMID:10684247|PMID:1385442]"
/experiment="EXISTENCE:direct assay:GO:0044613 nuclear
pore central transport channel [PMID:18046406]"
/experiment="EXISTENCE:direct assay:GO:0044614 nuclear
pore cytoplasmic filaments [PMID:14960378]"
/experiment="EXISTENCE:genetic interaction:GO:0016973
poly(A)+ mRNA export from nucleus [PMID:10952996]"
/experiment="EXISTENCE:genetic interaction:GO:0017056
structural constituent of nuclear pore
[PMID:11387327|PMID:17875746]"
/experiment="EXISTENCE:mutant phenotype:GO:0000055
ribosomal large subunit export from nucleus
[PMID:11071906]"
/experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA
export from nucleus [PMID:8524308|PMID:9802895]"
/experiment="EXISTENCE:mutant phenotype:GO:0006606 protein
import into nucleus [PMID:8557738]"
/experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear
pore organization [PMID:9463388]"
/experiment="EXISTENCE:mutant phenotype:GO:0016973
poly(A)+ mRNA export from nucleus
[PMID:8557738|PMID:9802895]"
/experiment="EXISTENCE:mutant phenotype:GO:0017056
structural constituent of nuclear pore [PMID:17418788]"
/experiment="EXISTENCE:physical interaction:GO:0006406
mRNA export from nucleus [PMID:11104765]"
/experiment="EXISTENCE:physical interaction:GO:0017056
structural constituent of nuclear pore
[PMID:12917401|PMID:17803941|PMID:17418788]"
/note="FG-nucleoporin component of central core of the
nuclear pore complex; contributes directly to
nucleocytoplasmic transport and maintenance of the nuclear
pore complex (NPC) permeability barrier; forms a stable
association with Nup82p, Gle2p and two other
FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog,
NUP100, that arose from the whole genome duplication"
/codon_start=1
/product="FG-nucleoporin NUP116"
/protein_id="NP_013762.1"
/db_xref="GeneID:855066"
/db_xref="SGD:S000004650"
/translation="MFGVSRGAFPSATTQPFGSTGSTFGGQQQQQQPVANTSAFGLSQ
QTNTTQAPAFGNFGNQTSNSPFGMSGSTTANGTPFGQSQLTNNNASGSIFGGMGNNTA
LSAGSASVVPNSTAGTSIKPFTTFEEKDPTTGVINVFQSITCMPEYRNFSFEELRFQD
YQAGRKFGTSQNGTGTTFNNPQGTTNTGFGIMGNNNSTTSATTGGLFGQKPATGMFGT
GTGSGGGFGSGATNSTGLFGSSTNLSGNSAFGANKPATSGGLFGNTTNNPTNGTNNTG
LFGQQNSNTNGGLFGQQQNSFGANNVSNGGAFGQVNRGAFPQQQTQQGSGGIFGQSNA
NANGGAFGQQQGTGALFGAKPASGGLFGQSAGSKAFGMNTNPTGTTGGLFGQTNQQQS
GGGLFGQQQNSNAGGLFGQNNQSQNQSGLFGQQNSSNAFGQPQQQGGLFGSKPAGGLF
GQQQGASTFASGNAQNNSIFGQNNQQQQSTGGLFGQQNNQSQSQPGGLFGQTNQNNNQ
PFGQNGLQQPQQNNSLFGAKPTGFGNTSLFSNSTTNQSNGISGNNLQQQSGGLFQNKQ
QPASGGLFGSKPSNTVGGGLFGNNQVANQNNPASTSGGLFGSKPATGSLFGGTNSTAP
NASSGGIFGSNNASNTAATTNSTGLFGNKPVGAGASTSAGGLFGNNNNSSLNNSNGST
GLFGSNNTSQSTNAGGLFQNNTSTNTSGGGLFSQPSQSMAQSQNALQQQQQQQRLQIQ
NNNPYGTNELFSKATVTNTVSYPIQPSATKIKADERKKASLTNAYKMIPKTLFTAKLK
TNNSVMDKAQIKVDPKLSISIDKKNNQIAISNQQEENLDESILKASELLFNPDKRSFK
NLINNRKMLIASEEKNNGSQNNDMNFKSKSEEQETILGKPKMDEKETANGGERMVLSS
KNDGEDSATKHHSRNMDEENKENVADLQKQEYSEDDKKAVFADVAEKDASFINENYYI
SPSLDTLSSYSLLQLRKVPHLVVGHKSYGKIEFLEPVDLAGIPLTSLGGVIITFEPKT
CIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQLVKRHIERLKKNP
NSKFESYDADSGTYVFIVNHAAEQT"
gene <366981..>367934
/gene="CSM3"
/locus_tag="YMR048W"
/db_xref="GeneID:855067"
mRNA <366981..>367934
/gene="CSM3"
/locus_tag="YMR048W"
/product="Csm3p"
/transcript_id="NM_001182545.1"
/db_xref="GeneID:855067"
CDS 366981..367934
/gene="CSM3"
/locus_tag="YMR048W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0031298 replication
fork protection complex [PMID:16531994]"
/experiment="EXISTENCE:genetic interaction:GO:0006281 DNA
repair [PMID:16219777]"
/experiment="EXISTENCE:genetic interaction:GO:0007064
mitotic sister chromatid cohesion
[PMID:14742714|PMID:17483413]"
/experiment="EXISTENCE:genetic interaction:GO:0034087
establishment of mitotic sister chromatid cohesion
[PMID:19730685]"
/experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
repair [PMID:16219777]"
/experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic
sister chromatid cohesion [PMID:14742714|PMID:17483413]"
/experiment="EXISTENCE:mutant phenotype:GO:0034087
establishment of mitotic sister chromatid cohesion
[PMID:19730685]"
/experiment="EXISTENCE:mutant phenotype:GO:0043111
replication fork arrest [PMID:16103218|PMID:16418273]"
/experiment="EXISTENCE:mutant phenotype:GO:0043570
maintenance of DNA repeat elements [PMID:18321795]"
/experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic
chromosome segregation [PMID:11470404]"
/note="Replication fork associated factor; required for
stable replication fork pausing; component of the DNA
replication checkpoint pathway; required for accurate
chromosome segregation during meiosis; forms nuclear foci
upon DNA replication stress"
/codon_start=1
/product="Csm3p"
/protein_id="NP_013763.1"
/db_xref="GeneID:855067"
/db_xref="SGD:S000004651"
/translation="MDQDFDSLLLGFNDSDSVQKDPTVPNGLDGSVVDPTIADPTAIT
ARKRRPQVKLTAEKLLSDKGLPYVLKNAHKRIRISSKKNSYDNLSNIIQFYQLWAHEL
FPKAKFKDFMKICQTVGKTDPVLREYRVSLFRDEMGMSFDVGTRETGQDLERQSPMVE
EHVTSAEERPIVADSFAQDKRNVNNVDYDNDEDDDIYHLSYRNRRGRVLDERGNNETV
LNNVVPPKEDLDALLKTFRVQGPVGLEENEKKLLLGWLDAHRKMEKGSMTEEDVQLIQ
SLEEWEMNDIEGQHTHYDLLPGGDEFGVDQDELDAMKEMGF"
gene complement(<368094..>370517)
/gene="ERB1"
/locus_tag="YMR049C"
/db_xref="GeneID:855068"
mRNA complement(<368094..>370517)
/gene="ERB1"
/locus_tag="YMR049C"
/product="Erb1p"
/transcript_id="NM_001182546.1"
/db_xref="GeneID:855068"
CDS complement(368094..370517)
/gene="ERB1"
/locus_tag="YMR049C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0030687
preribosome, large subunit precursor
[PMID:11583614|PMID:17443350|PMID:23212245]"
/experiment="EXISTENCE:direct assay:GO:0070180 large
ribosomal subunit rRNA binding [PMID:21811236]"
/experiment="EXISTENCE:direct assay:GO:0070545 PeBoW
complex [PMID:16287855]"
/experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA
processing [PMID:11522832]"
/experiment="EXISTENCE:physical interaction:GO:0042273
ribosomal large subunit biogenesis [PMID:16287855]"
/experiment="EXISTENCE:physical interaction:GO:0070545
PeBoW complex [PMID:16287855]"
/note="Constituent of 66S pre-ribosomal particles; forms a
complex with Nop7p and Ytm1p that is required for
maturation of the large ribosomal subunit; required for
maturation of the 25S and 5.8S ribosomal RNAs; binds RNA
via its C-terminal domain; homologous to mammalian Bop1"
/codon_start=1
/product="Erb1p"
/protein_id="NP_013764.1"
/db_xref="GeneID:855068"
/db_xref="SGD:S000004652"
/translation="MMAKNNKTTEAKMSKKRAASEESDVEEDEDKLLSVDGLIDAEAS
ESDEDDDEYESAVEEKESSSDKEAQDDSDDDSDAELNKLLAEEEGDGEEDYDSSEFSD
DTTSLTDRLSGVKLQTIVDPNIYSKYADGSDRIIKPEINPVYDSDDSDAETQNTIGNI
PLSAYDEMPHIGYDINGKRIMRPAKGSALDQLLDSIELPEGWTGLLDKNSGSSLNLTK
EELELISKIQRNEQTDDSINPYEPLIDWFTRHEEVMPLTAVPEPKRRFVPSKNEAKRV
MKIVRAIREGRIIPPKKLKEMKEKEKIENYQYDLWGDSTETNDHVMHLRAPKLPPPTN
EESYNPPEEYLLSPEEKEAWENTEYSERERNFIPQKYSALRKVPGYGESIRERFERSL
DLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGL
WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGE
NIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKN
AVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIH
QVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARW
LSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSS
AADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGA
DNTARLWTT"
rep_origin 371001..371105
/note="ARS1312; Autonomously Replicating Sequence"
/db_xref="SGD:S000118371"
gene complement(372445..372518)
/locus_tag="YNCM0021C"
/db_xref="GeneID:855069"
tRNA complement(372445..372518)
/locus_tag="YNCM0021C"
/product="tRNA-Val"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Valine tRNA (tRNA-Val), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:855069"
/db_xref="SGD:S000006763"
mobile_element complement(372697..378622)
/note="YMRCTy1-4; Ty1 element, LTR retrotransposon of the
Copia (Pseudoviridae) group; contains co-transcribed genes
TYA Gag and TYB Pol, encoding proteins involved in
structure and function of virus-like particles, flanked by
two direct repeats"
/mobile_element_type="retrotransposon:YMRCTy1-4"
/db_xref="SGD:S000007120"
repeat_region complement(372697..373034)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007111"
gene complement(<373057..>378325)
/locus_tag="YMR050C"
/db_xref="GeneID:855070"
mRNA complement(<373057..>378325)
/locus_tag="YMR050C"
/product="gag-pol fusion protein"
/transcript_id="NM_001182547.2"
/db_xref="GeneID:855070"
CDS complement(join(373057..377019,377021..378325))
/locus_tag="YMR050C"
/EC_number="2.7.7.7"
/EC_number="2.7.7.49"
/EC_number="3.1.26.4"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9448009]"
/ribosomal_slippage
/note="Retrotransposon TYA Gag and TYB Pol genes;
transcribed/translated as one unit; polyprotein is
processed to make a nucleocapsid-like protein (Gag),
reverse transcriptase (RT), protease (PR), and integrase
(IN); similar to retroviral genes"
/codon_start=1
/product="gag-pol fusion protein"
/protein_id="NP_013765.1"
/db_xref="GeneID:855070"
/db_xref="SGD:S000004653"
/translation="MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYD
KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS
FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS
DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT
FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ
YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM
TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN
SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHS
DDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQD
NTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWV
SKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNE
SDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKS
APSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSE
YTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFS
AIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGI
PGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLT
ASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTE
DSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAP
MSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKR
IIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPD
PFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSL
EPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLL
KMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDPGMQS
NTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLK
KSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDL
NANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIP
KLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRF
DLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISD
ASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSH
LVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCY
IETKKNIADVMTKPLPIKTFKLLTNKWIH"
gene complement(<377003..>378325)
/locus_tag="YMR051C"
/db_xref="GeneID:855071"
mRNA complement(<377003..>378325)
/locus_tag="YMR051C"
/product="gag protein"
/transcript_id="NM_001182548.1"
/db_xref="GeneID:855071"
CDS complement(377003..378325)
/locus_tag="YMR051C"
/note="Retrotransposon TYA Gag gene co-transcribed with
TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is
a nucleocapsid protein that is the structural constituent
of virus-like particles (VLPs); similar to retroviral Gag"
/codon_start=1
/product="gag protein"
/protein_id="NP_013766.1"
/db_xref="GeneID:855071"
/db_xref="SGD:S000004654"
/translation="MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYD
KASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWS
FYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADS
DMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELT
FLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQ
YNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNM
TVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNN
SKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY"
repeat_region complement(378285..378622)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007112"
repeat_region complement(378727..379061)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007113"
repeat_region 379072..379198
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007121"
gene complement(379303..379408)
/locus_tag="YNCM0022C"
/db_xref="GeneID:855072"
tRNA complement(join(379303..379338,379373..379408))
/locus_tag="YNCM0022C"
/product="tRNA-Trp"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Tryptophan tRNA (tRNA-Trp), predicted by
tRNAscan-SE analysis"
/db_xref="GeneID:855072"
/db_xref="SGD:S000006775"
gene <379586..>380200
/gene="FAR3"
/locus_tag="YMR052W"
/db_xref="GeneID:855073"
mRNA <379586..>380200
/gene="FAR3"
/locus_tag="YMR052W"
/product="Far3p"
/transcript_id="NM_001182550.1"
/db_xref="GeneID:855073"
CDS 379586..380200
/gene="FAR3"
/locus_tag="YMR052W"
/experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis
cisterna [PMID:22782902]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:23625923]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0000321
re-entry into mitotic cell cycle after pheromone arrest
[PMID:12588993]"
/experiment="EXISTENCE:mutant phenotype:GO:0000321
re-entry into mitotic cell cycle after pheromone arrest
[PMID:12588993]"
/note="hypothetical protein; involved in recovery from
cell cycle arrest in response to pheromone, in a
Far1p-independent pathway; interacts with Far7p, Far8p,
Far9p, Far10p, and Far11p; localizes to the endoplasmic
reticulum; protein abundance increases in response to DNA
replication stress"
/codon_start=1
/product="Far3p"
/protein_id="NP_013767.1"
/db_xref="GeneID:855073"
/db_xref="SGD:S000004656"
/translation="MNSGGSDSFDYLLQLTKALSAECRANRQETDRIELLLKRLAKQS
GISYDNLSKNIIPDSWKDNASQKASPPTEAQKLISENFKLIYEIEKQEYFNTKAVALI
NNINEHFSYIKNFIDEQNAIRERNIATFSSEKLDERNKSLQQNYESLKTENEETKKKL
HSIIKQFEKLLKEVDWDRISKDSRDYSRFKKQLEYLQDTYQVLK"
gene complement(<380346..>382898)
/gene="STB2"
/locus_tag="YMR053C"
/db_xref="GeneID:855075"
mRNA complement(<380346..>382898)
/gene="STB2"
/locus_tag="YMR053C"
/product="Stb2p"
/transcript_id="NM_001182551.1"
/db_xref="GeneID:855075"
CDS complement(380346..382898)
/gene="STB2"
/locus_tag="YMR053C"
/experiment="EXISTENCE:direct assay:GO:0070822 Sin3-type
complex [PMID:9393435]"
/experiment="EXISTENCE:physical interaction:GO:0070822
Sin3-type complex [PMID:9393435]"
/note="Protein that interacts with Sin3p in a two-hybrid
assay; part of a large protein complex with Sin3p and
Stb1p; STB2 has a paralog, STB6, that arose from the whole
genome duplication"
/codon_start=1
/product="Stb2p"
/protein_id="NP_013769.1"
/db_xref="GeneID:855075"
/db_xref="SGD:S000004657"
/translation="MVMADTIATGDKTSQFDGKHMQDLERIYSTRDTLDDNFFGERGQ
KDANGDYYDELNNEETNYSGSSYYGHSDDSEVVGLIKNDTVSQLPPLDSFIFPDSRAL
FLLDLGNYADLTYEEIIVHGFEIYIVEQWVACRNLSTLITSYTGNSQDTISGVRVVLP
KDTSMWPGRFRLYFEELMEFARPKFTPKGTLFITNLSGVSFGLNLLHVECGDLRTIWK
DFEVNFDLKNLHCGGRSANLLCPPTMASLDKFSQLFKIPTNGFIAQYPQMIQQQQPRL
PEEEYKTVGNSKCRNTDSKSPVVEMVTLIQISLSYFNLLSKNYQTDGLLCEDTKRAID
EWWETYGKLYLGTEKPRNECTLGPTTVAGLISLILCCYFKLMIENCISSKDPFDEAGF
FQGIYNFQKKHGLNKRKSRVYLDPRTLEKLFEVTAKVSSKDIFKLKKMVTSTVQDIIG
KGNPINLSHKILTTDLDTLIHNIHGGSVGLLWKGKGHPRKCCTDISNEEFLKFNYQRG
DPDGQIREREMLLEKFRLERIAYAQKHASKKVSSSSLDTSEDIGRTNAMPSSATVSSM
FPNYDNTKYAYNFGINKLYQGEYYRRNSFPYCKDRTHDNIYEDLSELKEKSSRLYRCN
SSSAVQNIVEKWDLPFDPSVVRIARDLLRMKYDIQAQQHIQEMDEHYMGKLNKEGTVG
QYSKFNERYKRLQELYKKYSDGAKVFEGRFEDIDNKQQLLLHEMQELNSLSSRLKYDM
RILEVRVRDIESSVAQFDSKLIGLKSSLQGQGKTGICSAIDPKSDKDEYDRCVNDLMT
TNNPTYEALCLKMLSRRYFKDLKNDTVGWFRWLFGNNSLHNNASEDDRGIRV"
gene <383303..>385975
/gene="STV1"
/locus_tag="YMR054W"
/db_xref="GeneID:855076"
mRNA <383303..>385975
/gene="STV1"
/locus_tag="YMR054W"
/product="H(+)-transporting V0 sector ATPase subunit a"
/transcript_id="NM_001182552.1"
/db_xref="GeneID:855076"
CDS 383303..385975
/gene="STV1"
/locus_tag="YMR054W"
/experiment="EXISTENCE:direct assay:GO:0000220 vacuolar
proton-transporting V-type ATPase, V0 domain
[PMID:7514599]"
/experiment="EXISTENCE:direct assay:GO:0005770 late
endosome [PMID:11592965]"
/experiment="EXISTENCE:direct assay:GO:0005794 Golgi
apparatus [PMID:11592965|PMID:11948198]"
/experiment="EXISTENCE:direct assay:GO:0070273
phosphatidylinositol-4-phosphate binding [PMID:28720663]"
/experiment="EXISTENCE:genetic interaction:GO:0007035
vacuolar acidification [PMID:11278748|PMID:7514599]"
/experiment="EXISTENCE:genetic interaction:GO:0046961
proton-transporting ATPase activity, rotational mechanism
[PMID:7514599]"
/experiment="EXISTENCE:mutant phenotype:GO:0007035
vacuolar acidification [PMID:11278748]"
/experiment="EXISTENCE:mutant phenotype:GO:0070273
phosphatidylinositol-4-phosphate binding [PMID:28720663]"
/note="Subunit a of vacuolar-ATPase V0 domain; encodes one
of two isoforms, located in both Golgi and endosomal
V-ATPase complexes while VPH1 encodes second isoform and
is located in vacuolar V-ATPase complexes; interaction
with PI(4)P is required for efficient localization and
function of Stv1-containing V-ATPases; targeted to vacuole
via AP-3 pathway"
/codon_start=1
/product="H(+)-transporting V0 sector ATPase subunit a"
/protein_id="NP_013770.1"
/db_xref="GeneID:855076"
/db_xref="SGD:S000004658"
/translation="MNQEEAIFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLN
KDLTAFQRGYVNQLRRFDEVERMVGFLNEVVEKHAAETWKYILHIDDEGNDIAQPDMA
DLINTMEPLSLENVNDMVKEITDCESRARQLDESLDSLRSKLNDLLEQRQVIFECSKF
IEVNPGIAGRATNPEIEQEERDVDEFRMTPDDISETLSDAFSFDDETPQDRGALGNDL
TRNQSVEDLSFLEQGYQHRYMITGSIRRTKVDILNRILWRLLRGNLIFQNFPIEEPLL
EGKEKVEKDCFIIFTHGETLLKKVKRVIDSLNGKIVSLNTRSSELVDTLNRQIDDLQR
ILDTTEQTLHTELLVIHDQLPVWSAMTKREKYVYTTLNKFQQESQGLIAEGWVPSTEL
IHLQDSLKDYIETLGSEYSTVFNVILTNKLPPTYHRTNKFTQAFQSIVDAYGIATYKE
INAGLATVVTFPFMFAIMFGDMGHGFILFLMALFLVLNERKFGAMHRDEIFDMAFTGR
YVLLLMGAFSVYTGLLYNDIFSKSMTIFKSGWQWPSTFRKGESIEAKKTGVYPFGLDF
AWHGTDNGLLFSNSYKMKLSILMGYAHMTYSFMFSYINYRAKNSKVDIIGNFIPGLVF
MQSIFGYLSWAIVYKWSKDWIKDDKPAPGLLNMLINMFLAPGTIDDQLYSGQAKLQVV
LLLAALVCVPWLLLYKPLTLRRLNKNGGGGRPHGYQSVGNIEHEEQIAQQRHSAEGFQ
GMIISDVASVADSINESVGGGEQGPFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWA
LSLAHAQLSSVLWDMTISNAFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSA
MLHALRLHWVEAMSKFFEGEGYAYEPFSFRAIIE"
gene complement(<386101..>387021)
/gene="BUB2"
/locus_tag="YMR055C"
/gene_synonym="PAC7"
/db_xref="GeneID:855077"
mRNA complement(<386101..>387021)
/gene="BUB2"
/locus_tag="YMR055C"
/gene_synonym="PAC7"
/product="Bub2p"
/transcript_id="NM_001182553.1"
/db_xref="GeneID:855077"
CDS complement(386101..387021)
/gene="BUB2"
/locus_tag="YMR055C"
/gene_synonym="PAC7"
/experiment="EXISTENCE:direct assay:GO:0005096 GTPase
activator activity
[PMID:12048186|PMID:18667533|PMID:25658911]"
/experiment="EXISTENCE:direct assay:GO:0005816 spindle
pole body [PMID:10220406|PMID:10352016]"
/experiment="EXISTENCE:direct assay:GO:1990334 Bfa1-Bub2
complex [PMID:25658911]"
/experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase
activator activity [PMID:25658911]"
/experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic
spindle orientation checkpoint signaling
[PMID:16039591|PMID:25658911]"
/experiment="EXISTENCE:mutant phenotype:GO:1902543
negative regulation of protein localization to mitotic
spindle pole body [PMID:25658911]"
/experiment="EXISTENCE:physical interaction:GO:1990334
Bfa1-Bub2 complex [PMID:11493673]"
/note="Mitotic exit network regulator; forms
GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and
spindle pole bodies, blocks cell cycle progression before
anaphase in response to spindle and kinetochore damage"
/codon_start=1
/product="Bub2p"
/protein_id="NP_013771.1"
/db_xref="GeneID:855077"
/db_xref="SGD:S000004659"
/translation="MTSIEDLISNPPLLLHSSLSQLRYLILSEGLPISEDKQQQRTRC
YVWTVLSQTSMEASTQRYLALLKLGPPSTTIYQKIKNDTSRTFQTDPNFRNRVSEDAL
IRCLSCFAWQTQQRRQKTRFGRIPVSTYVQGMNVLLAPLLYSCPSEPMAYQLFTKLCY
EMIPTYLTKNLNGAQNGAKLLDISLRIIDPKLSKFLSDNLLTAEIYGMPSILTLSSCN
KPLDQVIKLWDFMFAYGFHMNILFVVAFLVKMRSKVFKSDSPVNLLRQFPDFDADEII
RLGVGFIAKIPAQIYDLLVDHLTDPDIYIP"
gene complement(<387315..>388244)
/gene="AAC1"
/locus_tag="YMR056C"
/db_xref="GeneID:855078"
mRNA complement(<387315..>388244)
/gene="AAC1"
/locus_tag="YMR056C"
/product="ADP/ATP carrier protein AAC1"
/transcript_id="NM_001182554.1"
/db_xref="GeneID:855078"
CDS complement(387315..388244)
/gene="AAC1"
/locus_tag="YMR056C"
/experiment="EXISTENCE:direct assay:GO:0005471 ATP:ADP
antiporter activity [PMID:2167309]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:22842922|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:12740376]"
/experiment="EXISTENCE:genetic interaction:GO:0006783 heme
biosynthetic process [PMID:18728780]"
/experiment="EXISTENCE:genetic interaction:GO:0006839
mitochondrial transport [PMID:2167309]"
/experiment="EXISTENCE:genetic interaction:GO:0009060
aerobic respiration [PMID:2167309]"
/experiment="EXISTENCE:mutant phenotype:GO:0015886 heme
transport [PMID:18728780]"
/note="Mitochondrial inner membrane ADP/ATP translocator;
exchanges cytosolic ADP for mitochondrially synthesized
ATP; phosphorylated; Aac1p is a minor isoform while Pet9p
is the major ADP/ATP translocator; relocalizes from
mitochondrion to cytoplasm upon DNA replication stress"
/codon_start=1
/product="ADP/ATP carrier protein AAC1"
/protein_id="NP_013772.1"
/db_xref="GeneID:855078"
/db_xref="SGD:S000004660"
/translation="MSHTETQTQQSHFGVDFLMGGVSAAIAKTGAAPIERVKLLMQNQ
EEMLKQGSLDTRYKGILDCFKRTATHEGIVSFWRGNTANVLRYFPTQALNFAFKDKIK
SLLSYDRERDGYAKWFAGNLFSGGAAGGLSLLFVYSLDYARTRLAADARGSKSTSQRQ
FNGLLDVYKKTLKTDGLLGLYRGFVPSVLGIIVYRGLYFGLYDSFKPVLLTGALEGSF
VASFLLGWVITMGASTASYPLDTVRRRMMMTSGQTIKYDGALDCLRKIVQKEGAYSLF
KGCGANIFRGVAAAGVISLYDQLQLIMFGKKFK"
gene <388822..>390732
/gene="FET3"
/locus_tag="YMR058W"
/db_xref="GeneID:855080"
mRNA <388822..>390732
/gene="FET3"
/locus_tag="YMR058W"
/product="ferroxidase FET3"
/transcript_id="NM_001182556.1"
/db_xref="GeneID:855080"
CDS 388822..390732
/gene="FET3"
/locus_tag="YMR058W"
/EC_number="1.16.3.1"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0004322 ferroxidase
activity [PMID:8599111|PMID:9722559]"
/experiment="EXISTENCE:direct assay:GO:0005381 iron ion
transmembrane transporter activity [PMID:16700543]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16700543|PMID:9162052]"
/experiment="EXISTENCE:direct assay:GO:0033573
high-affinity iron permease complex [PMID:16522632]"
/experiment="EXISTENCE:genetic interaction:GO:0034755 iron
ion transmembrane transport [PMID:8599111]"
/experiment="EXISTENCE:genetic interaction:GO:1901684
arsenate ion transmembrane transport [PMID:23295455]"
/experiment="EXISTENCE:mutant phenotype:GO:0033215
reductive iron assimilation [PMID:16700543]"
/experiment="EXISTENCE:mutant phenotype:GO:0034755 iron
ion transmembrane transport
[PMID:16700543|PMID:8293473|PMID:8599111]"
/experiment="EXISTENCE:mutant phenotype:GO:0046688
response to copper ion [PMID:12954629]"
/note="Ferro-O2-oxidoreductase; multicopper oxidase that
oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for
subsequent cellular uptake by transmembrane permease
Ftr1p; required for high-affinity iron uptake and involved
in mediating resistance to copper ion toxicity, belongs to
class of integral membrane multicopper oxidases; protein
abundance increases in response to DNA replication stress"
/codon_start=1
/product="ferroxidase FET3"
/protein_id="NP_013774.1"
/db_xref="GeneID:855080"
/db_xref="SGD:S000004662"
/translation="MTNALLSIAVLLFSMLSLAQAETHTFNWTTGWDYRNVDGLKSRP
VITCNGQFPWPDITVNKGDRVQIYLTNGMNNTNTSMHFHGLFQNGTASMDGVPFLTQC
PIAPGSTMLYNFTVDYNVGTYWYHSHTDGQYEDGMKGLFIIKDDSFPYDYDEELSLSL
SEWYHDLVTDLTKSFMSVYNPTGAEPIPQNLIVNNTMNLTWEVQPDTTYLLRIVNVGG
FVSQYFWIEDHEMTVVEIDGITTEKNVTDMLYITVAQRYTVLVHTKNDTDKNFAIMQK
FDDTMLDVIPSDLQLNATSYMVYNKTAALPTQNYVDSIDNFLDDFYLQPYEKEAIYGE
PDHVITVDVVMDNLKNGVNYAFFNNITYTAPKVPTLMTVLSSGDQANNSEIYGSNTHT
FILEKDEIVEIVLNNQDTGTHPFHLHGHAFQTIQRDRTYDDALGEVPHSFDPDNHPAF
PEYPMRRDTLYVRPQSNFVIRFKADNPGVWFFHCHIEWHLLQGLGLVLVEDPFGIQDA
HSQQLSENHLEVCQSCSVATEGNAAANTLDLTDLTGENVQHAFIPTGFTKKGIIAMTF
SCFAGILGIITIAIYGMMDMEDATEKVIRDLHVDPEVLLNEVDENEERQVNEDRHSTE
KHQFLTKAKRFF"
gene <391099..>391485
/gene="SEN15"
/locus_tag="YMR059W"
/db_xref="GeneID:855081"
mRNA <391099..>391485
/gene="SEN15"
/locus_tag="YMR059W"
/product="Sen15p"
/transcript_id="NM_001182557.1"
/db_xref="GeneID:855081"
CDS 391099..391485
/gene="SEN15"
/locus_tag="YMR059W"
/experiment="EXISTENCE:direct assay:GO:0000213 tRNA-intron
endonuclease activity [PMID:9200603]"
/experiment="EXISTENCE:direct assay:GO:0000214 tRNA-intron
endonuclease complex [PMID:9200603]"
/experiment="EXISTENCE:direct assay:GO:0000379 tRNA-type
intron splice site recognition and cleavage
[PMID:9200603]"
/note="Subunit of the tRNA splicing endonuclease; tRNA
splicing endonuclease (Sen complex) is composed of Sen2p,
Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the
CBP1 mRNA at the mitochondrial surface"
/codon_start=1
/product="Sen15p"
/protein_id="NP_013775.2"
/db_xref="GeneID:855081"
/db_xref="SGD:S000004663"
/translation="MATTDIISLVKNNLLYFQMWTEVEILQDDLSWKGNSLRLLRGRP
PHKLSNDVDTEHENSLSSPRPLEFILPINMSQYKENFLTLECLSQTFTHLCSPSTERI
LLAIINDDGTIVYYFVYKGVRKPKRN"
gene complement(<391532..>392515)
/gene="SAM37"
/locus_tag="YMR060C"
/gene_synonym="MAS37; PET3027; TOM37"
/db_xref="GeneID:855082"
mRNA complement(<391532..>392515)
/gene="SAM37"
/locus_tag="YMR060C"
/gene_synonym="MAS37; PET3027; TOM37"
/product="SAM complex subunit SAM37"
/transcript_id="NM_001182558.1"
/db_xref="GeneID:855082"
CDS complement(391532..392515)
/gene="SAM37"
/locus_tag="YMR060C"
/gene_synonym="MAS37; PET3027; TOM37"
/experiment="EXISTENCE:direct assay:GO:0001401 SAM complex
[PMID:12891361]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:mutant phenotype:GO:0015914
phospholipid transport [PMID:21299651]"
/experiment="EXISTENCE:mutant phenotype:GO:0045040 protein
insertion into mitochondrial outer membrane
[PMID:18039934]"
/experiment="EXISTENCE:mutant phenotype:GO:0070096
mitochondrial outer membrane translocase complex assembly
[PMID:12891361|PMID:18039934]"
/note="Component of the Sorting and Assembly Machinery
(SAM) complex; the SAM (or TOB) complex is located in the
mitochondrial outer membrane; binds precursors of
beta-barrel proteins and facilitates their outer membrane
insertion; contributes to SAM complex stability"
/codon_start=1
/product="SAM complex subunit SAM37"
/protein_id="NP_013776.1"
/db_xref="GeneID:855082"
/db_xref="SGD:S000004664"
/translation="MVKGSVHLWGKDGKASLISVDSIALVWFIKLCTSEEAKSMVAGL
QIVFSNNTDLSSDGKLPVLILDNGTKVSGYVNIVQFLHKNICTSKYEKGTDYEEDLAI
VRKKDRLLEYSLLNYVDVEISRLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQ
LRSQARENCEEIIGSLTLEDDEEFVESKAMESASQLAQSKTFKIAHKNKIKGKQELQQ
VKYNLQFDNRLQSCVSNWLAARKKLDDSVILSSDLLFLANLYVQLGLPDGNRIRSKLE
QTFGSELLNSMSNKIDDFVHRPSNNLEQRDPQFREQGNVVMSLYNLACKYI"
gene <392755..>394788
/gene="RNA14"
/locus_tag="YMR061W"
/db_xref="GeneID:855083"
mRNA <392755..>394788
/gene="RNA14"
/locus_tag="YMR061W"
/product="cleavage polyadenylation factor subunit RNA14"
/transcript_id="NM_001182559.1"
/db_xref="GeneID:855083"
CDS 392755..394788
/gene="RNA14"
/locus_tag="YMR061W"
/experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
[PMID:15215336]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10660071|PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:10660071]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0006397 mRNA
processing [PMID:11344258]"
/experiment="EXISTENCE:mutant phenotype:GO:0072423
response to DNA damage checkpoint signaling
[PMID:24603480]"
/experiment="EXISTENCE:physical interaction:GO:0005848
mRNA cleavage stimulating factor complex [PMID:11344258]"
/note="Component of the cleavage and polyadenylation
factor I (CF I); CF 1, composed of the CF 1A complex
(Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in
cleavage and polyadenylation of mRNA 3' ends; bridges
interaction between Rna15p and Hrp1p in the CF I complex;
mutant displays reduced transcription elongation in the
G-less-based run-on (GLRO) assay; required for gene
looping and maintenance of genome stability; relocalizes
to the cytosol in response to hypoxia"
/codon_start=1
/product="cleavage polyadenylation factor subunit RNA14"
/protein_id="NP_013777.1"
/db_xref="GeneID:855083"
/db_xref="SGD:S000004665"
/translation="MSSSTTPDLLYPSADKVAEPSDNIHGDELRLRERIKDNPTNILS
YFQLIQYLETQESYAKVREVYEQFHNTFPFYSPAWTLQLKGELARDEFETVEKILAQC
LSGKLENNDLSLWSTYLDYIRRKNNLITGGQEARAVIVKAFQLVMQKCAIFEPKSSSF
WNEYLNFLEQWKPFNKWEEQQRIDMLREFYKKMLCVPFDNLEKMWNRYTQWEQEINSL
TARKFIGELSAEYMKARSLYQEWLNVTNGLKRASPINLRTANKKNIPQPGTSDSNIQQ
LQIWLNWIKWERENKLMLSEDMLSQRISYVYKQGIQYMIFSAEMWYDYSMYISENSDR
QNILYTALLANPDSPSLTFKLSECYELDNDSESVSNCFDKCTQTLLSQYKKIASDVNS
GEDNNTEYEQELLYKQREKLTFVFCVYMNTMKRISGLSAARTVFGKCRKLKRILTHDV
YVENAYLEFQNQNDYKTAFKVLELGLKYFQNDGVYINKYLDFLIFLNKDSQIKTLFET
SVEKVQDLTQLKEIYKKMISYESKFGNLNNVYSLEKRFFERFPQENLIEVFTSRYQIQ
NSNLIKKLELTYMYNEEEDSYFSSGNGDGHHGSYNMSSSDRKRLMEETGNNGNFSNKK
FKRDSELPTEVLDLLSVIPKRQYFNTNLLDAQKLVNFLNDQVEIPTVESTKSG"
gene complement(<395054..>396379)
/gene="ARG7"
/locus_tag="YMR062C"
/gene_synonym="ECM40"
/db_xref="GeneID:855084"
mRNA complement(<395054..>396379)
/gene="ARG7"
/locus_tag="YMR062C"
/gene_synonym="ECM40"
/product="glutamate N-acetyltransferase"
/transcript_id="NM_001182560.1"
/db_xref="GeneID:855084"
CDS complement(395054..396379)
/gene="ARG7"
/locus_tag="YMR062C"
/gene_synonym="ECM40"
/EC_number="2.3.1.1"
/EC_number="2.3.1.35"
/experiment="EXISTENCE:direct assay:GO:0004042
acetyl-CoA:L-glutamate N-acetyltransferase activity
[PMID:9428669]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:205532]"
/experiment="EXISTENCE:direct assay:GO:0006592 ornithine
biosynthetic process [PMID:9428669]"
/note="Mitochondrial ornithine acetyltransferase;
catalyzes the fifth step in arginine biosynthesis; also
possesses acetylglutamate synthase activity, regenerates
acetylglutamate while forming ornithine"
/codon_start=1
/product="glutamate N-acetyltransferase"
/protein_id="NP_013778.1"
/db_xref="GeneID:855084"
/db_xref="SGD:S000004666"
/translation="MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKN
GSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCA
NSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEK
FGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLG
FIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSK
DFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVK
TALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQL
EIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS"
gene <397077..>397796
/gene="RIM9"
/locus_tag="YMR063W"
/db_xref="GeneID:855085"
mRNA <397077..>397796
/gene="RIM9"
/locus_tag="YMR063W"
/product="Rim9p"
/transcript_id="NM_001182561.1"
/db_xref="GeneID:855085"
CDS 397077..397796
/gene="RIM9"
/locus_tag="YMR063W"
/experiment="EXISTENCE:direct assay:GO:0000328 fungal-type
vacuole lumen [PMID:33002606]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:23019326]"
/experiment="EXISTENCE:mutant phenotype:GO:0030437
ascospore formation [PMID:8417990]"
/note="Plasma membrane hypothetical protein; involved in
the proteolytic activation of Rim101p in response to
alkaline pH; interacts with Rim21p and Dfg16p to form a
pH-sensing complex in the Rim101 pathway and is required
to maintain Rim21p levels; has similarity to A. nidulans
PalI"
/codon_start=1
/product="Rim9p"
/protein_id="NP_013779.1"
/db_xref="GeneID:855085"
/db_xref="SGD:S000004667"
/translation="MVSMIHIVVFLLAITTMFEILPLITVPVTKYLSLSSFRNHYYGL
FGWCVRGQNQELMCTKMKIGYDSTDVDSSGHVLTLPSNSKVVVSNLLVVHPISLAFTG
TLLILAVIIMVTPLGDSPEMLLFTALFSLPTFMLCLLCFLVDILLFISKLDWPGWLML
AATISVALCCSMLWVMRRVVSVKKYESQQSIAHACSMEQYSISDIYQSKQNGNSSEYE
VAPTHTDSLIAPEVTYRGFIE"
gene <397903..>399459
/gene="AEP1"
/locus_tag="YMR064W"
/gene_synonym="NCA1"
/db_xref="GeneID:855086"
mRNA <397903..>399459
/gene="AEP1"
/locus_tag="YMR064W"
/gene_synonym="NCA1"
/product="Aep1p"
/transcript_id="NM_001182562.1"
/db_xref="GeneID:855086"
CDS 397903..399459
/gene="AEP1"
/locus_tag="YMR064W"
/gene_synonym="NCA1"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0006417
regulation of translation [PMID:21454598]"
/experiment="EXISTENCE:mutant phenotype:GO:0045182
translation regulator activity [PMID:21454598]"
/note="Protein required for expression of the
mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes
subunit 9 of F1-F0 ATP synthase"
/codon_start=1
/product="Aep1p"
/protein_id="NP_013780.1"
/db_xref="GeneID:855086"
/db_xref="SGD:S000004668"
/translation="MITTVQEISKWRNLCFIRMQSRKWYPVLKKTPLVADGRKIIKHA
DKVPHPEEIIHPFYQPTAIEQFTACATEYNPSLLDGKKIAPSLIKHPVSLKTILVDSK
LKFDDIRGVNKWLMEFVARRQHQRNIVLTPASKSVRSFHVLHLSSTDIAKLRGLENIL
SEIENTNDLQSRVESVNNELQNIFDRDSKQTRLFCENILAYLIKNYGNSTEKLILLIN
VTEMQLYSRLDQMKAMNIILYNILCKVEANENPPYSPTLVTALENLLAAINNRFFPGR
CENSLHPIVIEQLLSYFIKTGNLNESKNFLGHLIKKGILPEATIINRYLEAIDVHFDK
STKIFDIRSKFAFIADLAPIIENYGTIDLFKFLIPMCRHFDELCSLLNIIRKSNNAKR
AVDSTLPIFIKKVLTFTKDPMINSGNLSTVFNIVSPIYGQNVPSEFVEKFILSFALQG
NYTMMAHMIDTYKIKLSHKYQLQIIRALKNSERNHALKNTGAVGYNKEFKKYFIEKYL
NCTEREALRP"
gene <399702..>401216
/gene="KAR5"
/locus_tag="YMR065W"
/gene_synonym="FIG3"
/db_xref="GeneID:855087"
mRNA <399702..>401216
/gene="KAR5"
/locus_tag="YMR065W"
/gene_synonym="FIG3"
/product="Kar5p"
/transcript_id="NM_001182563.1"
/db_xref="GeneID:855087"
CDS 399702..401216
/gene="KAR5"
/locus_tag="YMR065W"
/gene_synonym="FIG3"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:9382856]"
/experiment="EXISTENCE:mutant phenotype:GO:0000742
karyogamy involved in conjugation with cellular fusion
[PMID:10069807]"
/note="Protein required for nuclear membrane fusion during
karyogamy; localizes to the membrane with a soluble
portion in the endoplasmic reticulum lumen, may form a
complex with Jem1p and Kar2p; similar to zebrafish
Brambleberry protein; expression of the gene is regulated
by pheromone"
/codon_start=1
/product="Kar5p"
/protein_id="NP_013781.1"
/db_xref="GeneID:855087"
/db_xref="SGD:S000004669"
/translation="MFEMRYVYLFAICIKFVSSSELGKINNLLQGRLIYTDNSVATNV
LESKFPFLKSTCVKDALKLFLPQCIANGLESIDAETRVETAIKLSICEFQASGLGEIP
ENCMVDDLGSMMDCMFELESSSQWWTTYSGNYQRLSSICYENLLPFEKEQILKLFLNI
TELYDSFGDDVDTKLNHLMFQMEQDSQNFLDDLARMFRNYDNELRNATESNRIILEND
LSFFRNKVNDVLYETSEQLEVQIIEKNSQLMNEVDTVHHIMSDLADELAKNDIKSKIN
DLKDDSLNNLQDLVEMSNDVKEYYSRNNKLVNTELENFSMGLKKQLGGMSKDLSESQM
EAIELLQGFNSILHDSLLPSMTDEIVPEMTNFKNTLLQEWTAITSTLNGDFALWNEEI
FSTFNDISEKLNGTKKKLDDIEIRVSLVHKNVMTMMRVLDFMWKTSKMIIRCGYLAVK
NKYYWLLCSVVWIWSKYRTSRVNVKMIPIKRYYQWAALLLSIYLGAKTGSLIDF"
gene <401541..>404237
/gene="SOV1"
/locus_tag="YMR066W"
/db_xref="GeneID:855088"
mRNA <401541..>404237
/gene="SOV1"
/locus_tag="YMR066W"
/product="Sov1p"
/transcript_id="NM_001182564.1"
/db_xref="GeneID:855088"
CDS 401541..404237
/gene="SOV1"
/locus_tag="YMR066W"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:mutant phenotype:GO:0008494
translation activator activity [PMID:32449921]"
/experiment="EXISTENCE:mutant phenotype:GO:0032543
mitochondrial translation [PMID:32449921]"
/experiment="EXISTENCE:mutant phenotype:GO:0061668
mitochondrial ribosome assembly [PMID:32449921]"
/note="Mitochondrial hypothetical protein"
/codon_start=1
/product="Sov1p"
/protein_id="NP_013782.1"
/db_xref="GeneID:855088"
/db_xref="SGD:S000004670"
/translation="MFKYNRSLCSSALIAKSQIRFYRLKRAPLNYASHIPEVLNKTII
GPDEPEKCLILKGKTSEEIENNLLSNKKFQEINPLDTIQETFIQYLKFCNETNFKRSN
KNLNRLKKTLESKDSNSTVKINAVFNYLLEECDLEIKRLNTTGQTQVYNEEKGNEDDL
EQSIMNDIFRSAQEQFEDQEGHIPLRSTSFLLEILKSFNERFNGIIKPKESITEMVTF
SQLAQAFEVVKLIPVQEMKEKGIYLVGNLLYGTGKVRLDPINESFYIESLLVFGNYKA
AYSLFITNKDKVNERWWNELGLMITLRSNHLRNFRKLLAETDAKYSTKYSYLSPRVTK
LSIRKYLSIGNVTEANILTDRFIKLVEEVGIIRMKDEQEELPTGVKNFQNEKHATEFL
NELEIPSDHDYISIVDFHLYKRNIPMAAQLISKYMEIPGTTQEDAAFLLVKTKLNMLK
DFEKLRNIFAQNKDYVVPENNVKMLQEAFESVITKYNTNSPIYNELLFENVSALTKSI
VLTDFLEEFITKQASGQWMELNSVSRSRKFNGLLNILLGTGEEEKAYNILKKLEEASK
KSKTDPDLLYNQFYSEVNAYHYAKFVEFYSLQIQNMKAQNTPSFRKKEFKQKVKSLLK
RMQESEVIPNAVFLREILNFYDSMYDFNSSFEIINPLLESKQQVSSESSLSTSNPCRF
YNRRIITKPLYHKIWSVYCHYYHVLQNNSRILSKKSSIVKKLIKRQIKIHPTCHPRVL
FQMTAENGEILPDKTFSKLIVSTFMKSGDLEAIPAILTFLTKKFDLNIDYDLSMYILK
GLKRQYLRDISNISKDACEYKLRKAELMNNESILKNIPQGTNQENTISHLIREILIFI
KWKEKSDCSTFLMVEDAFKELGTEFTLLEELIEDVNKLKIKA"
gene complement(<404323..>405573)
/gene="UBX4"
/locus_tag="YMR067C"
/gene_synonym="CUI1"
/db_xref="GeneID:855089"
mRNA complement(<404323..>405573)
/gene="UBX4"
/locus_tag="YMR067C"
/gene_synonym="CUI1"
/product="Ubx4p"
/transcript_id="NM_001182565.1"
/db_xref="GeneID:855089"
CDS complement(404323..405573)
/gene="UBX4"
/locus_tag="YMR067C"
/gene_synonym="CUI1"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:14755638]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:19359248]"
/experiment="EXISTENCE:genetic interaction:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:21148305]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:19359248]"
/experiment="EXISTENCE:mutant phenotype:GO:0030435
sporulation resulting in formation of a cellular spore
[PMID:14755638]"
/note="UBX domain-containing protein that interacts with
Cdc48p; involved in degradation of polyubiquitinated
proteins via the ERAD (ER-associated degradation) pathway;
modulates the role of the Cdc48p-Nplp-Ufd1p AAA ATPase
complex in delivery of misfolded proteins to the
proteasome; protein abundance increases in response to DNA
replication stress; human ortholog ASPSCR1 partially
complements the yeast null mutant"
/codon_start=1
/product="Ubx4p"
/protein_id="NP_013783.1"
/db_xref="GeneID:855089"
/db_xref="SGD:S000004671"
/translation="MPMVTVKYNFQLFKCKVSLNSTLNDVLHQSIQFFQLHTSSNDWS
LIHLDKPVPLDLPWRLLNLPTGVNLELSKSSNFPVANKTNREDIPFNTIKIRFQIPGR
DSVVKEMPSDQPIAPILRQMSGAAGDDFKIQVFSKIIEFKTIKDENLTLENLGIQEPS
SVRLIFNNTSHSEGISANSAIHPKQTPPTMTNPETVASLPPHELHKPSVFLPSDEPLA
VIKDQIEDEEDYELTVEQAKKYQKMLSSKAGTLGGPILTKRLREQSANNLPKKNKAIS
ECLLRVKFPDRSHIQIAFKPNEDMRTVYNVVSQFLIDENMPFTLNQSHPFKPLAKDDK
KLLDDLEFGSKTMLLFETNSNSNGPLIKAHLLEDAQKITHETRTTPSVNTINKSNPQG
PSDNATSIKKTLNRVPKWMKLSKK"
gene <406304..>407584
/gene="AVO2"
/locus_tag="YMR068W"
/db_xref="GeneID:855090"
mRNA <406304..>407584
/gene="AVO2"
/locus_tag="YMR068W"
/product="Avo2p"
/transcript_id="NM_001182566.1"
/db_xref="GeneID:855090"
CDS 406304..407584
/gene="AVO2"
/locus_tag="YMR068W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:30969890]"
/experiment="EXISTENCE:physical interaction:GO:0001558
regulation of cell growth [PMID:12408816]"
/experiment="EXISTENCE:physical interaction:GO:0030950
establishment or maintenance of actin cytoskeleton
polarity [PMID:12408816]"
/experiment="EXISTENCE:physical interaction:GO:0031932
TORC2 complex [PMID:12408816]"
/note="Subunit of TORC2, a regulator of plasma membrane
(PM) homeostasis; TORC2 also regulates actin cytoskeletal
dynamics during polarized growth and cell wall integrity;
interacts with Slm1p and Slm2p, homologous PH
domain-containing TORC2 substrates; PM retention is
dependent on Avo3p"
/codon_start=1
/product="Avo2p"
/protein_id="NP_013784.1"
/db_xref="GeneID:855090"
/db_xref="SGD:S000004672"
/translation="MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSL
HYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFI
NHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKM
LLNEGEVSLDDNVRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFR
TPILNAKATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITN
PVFNPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSP
HNNIALINRYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENK
YKIKVNNGEPRRRVSLLNIPISKLRNSNNTRAED"
gene <407709..>408566
/gene="NAT4"
/locus_tag="YMR069W"
/gene_synonym="NAA40"
/db_xref="GeneID:855091"
mRNA <407709..>408566
/gene="NAT4"
/locus_tag="YMR069W"
/gene_synonym="NAA40"
/product="N-terminal L-serine N(alpha)-acetyltransferase
NatD"
/transcript_id="NM_001182567.1"
/db_xref="GeneID:855091"
CDS 407709..408566
/gene="NAT4"
/locus_tag="YMR069W"
/gene_synonym="NAA40"
/EC_number="2.3.1.257"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0010485 histone H4
acetyltransferase activity [PMID:12915400]"
/experiment="EXISTENCE:mutant phenotype:GO:0010485 histone
H4 acetyltransferase activity [PMID:12915400]"
/experiment="EXISTENCE:mutant phenotype:GO:0031507
heterochromatin formation [PMID:24068969]"
/experiment="EXISTENCE:mutant phenotype:GO:0043998 histone
H2A acetyltransferase activity [PMID:12915400]"
/note="N alpha-acetyl-transferase; involved in acetylation
of the N-terminal residues of histones H4 and H2A"
/codon_start=1
/product="N-terminal L-serine N(alpha)-acetyltransferase
NatD"
/protein_id="NP_013785.1"
/db_xref="GeneID:855091"
/db_xref="SGD:S000004673"
/translation="MRSSVYSENTYNCIRTSKEHLTERRRVAMAPMFQHFLNLCVEKF
PESIEHKDTDGNGNFTTAILEREIIYIPEDDTDSIDSVDSLKCINYKLHKSRGDQVLD
ACVQLIDKHLGAKYRRASRIMYGNRKPWKANKLAEMKSAGLVYVCYWDNGVLGAFTSF
MLTEETGLVEGDALHEVSVPVIYLYEVHVASAHRGHGIGRRLLEHALCDGVARHTRRM
CDNFFGVALTVFSDNTRARRLYEALGFYRAPGSPAPASPTIRHTRHGGGRVVVPCDPL
YYVYCLHMP"
gene <409154..>410626
/gene="MOT3"
/locus_tag="YMR070W"
/gene_synonym="ROX7"
/db_xref="GeneID:855092"
mRNA <409154..>410626
/gene="MOT3"
/locus_tag="YMR070W"
/gene_synonym="ROX7"
/product="Mot3p"
/transcript_id="NM_001182568.1"
/db_xref="GeneID:855092"
CDS 409154..410626
/gene="MOT3"
/locus_tag="YMR070W"
/gene_synonym="ROX7"
/experiment="EXISTENCE:direct assay:GO:0000978 RNA
polymerase II cis-regulatory region sequence-specific DNA
binding [PMID:9611199|PMID:10982825]"
/experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding
transcription factor activity, RNA polymerase II-specific
[PMID:23435728]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276|PMID:14562095|PMID:22932476|PMID:9611199]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:mutant phenotype:GO:0000122
negative regulation of transcription by RNA polymerase II
[PMID:12145211|PMID:10982825|PMID:21299653]"
/experiment="EXISTENCE:mutant phenotype:GO:0010895
negative regulation of ergosterol biosynthetic process
[PMID:12145211|PMID:21299653]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:11292809|PMID:23435728]"
/experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:14665463]"
/experiment="EXISTENCE:physical interaction:GO:0061629 RNA
polymerase II-specific DNA-binding transcription factor
binding [PMID:16783004]"
/note="Transcriptional repressor, activator; role in
cellular adjustment to osmotic stress including modulation
of mating efficiency; involved in repression of subset of
hypoxic genes by Rox1p, repression of several DAN/TIR
genes during aerobic growth, ergosterol biosynthetic genes
in response to hyperosmotic stress; contributes to
recruitment of Tup1p-Cyc8p general repressor to promoters;
relocalizes to cytosol under hypoxia; forms [MOT3+] prion
under anaerobic conditions"
/codon_start=1
/product="Mot3p"
/protein_id="NP_013786.1"
/db_xref="GeneID:855092"
/db_xref="SGD:S000004674"
/translation="MNADHHLQQQQQQRQQHQQQQHQQQQHQHQHQQQQHTILQNVSN
TNNIGSDSLASQPFNTTTVSSNKDDVMVNSGARELPMPLHQQQYIYPYYQYTSNNSNN
NNVTAGNNMSASPIVHNNSNNSNNSNISASDYTVANNSTSNNNNNNNNNNNNNNNIHP
NQFTAAANMNSNAAAAAYYSFPTANMPIPQQDQQYMFNPASYISHYYSAVNSNNNGNN
AANNGSNNSSHSAPAPAPGPPHHHHHHSNTHNNLNNGGAVNTNNAPQHHPTIITDQFQ
FQLQQNPSPNLNLNINPAQPLHLPPGWKINTMPQPRPTTAPNHPPAPVPSSNPVASNL
VPAPSSDHKYIHQCQFCEKSFKRKSWLKRHLLSHSQQRHFLCPWCLSRQKRKDNLLQH
MKLKHTNYLLDELKKNNIIFNYNNSSSSNNNNDNNNNNNSNSASGSGGAGAAAAAATA
PENEDGNGYDTNIKTLINDGVLNKDDVKRVLNNLIVSHNK"
gene complement(<410762..>411265)
/gene="TVP18"
/locus_tag="YMR071C"
/db_xref="GeneID:855093"
mRNA complement(<410762..>411265)
/gene="TVP18"
/locus_tag="YMR071C"
/product="Tvp18p"
/transcript_id="NM_001182569.1"
/db_xref="GeneID:855093"
CDS complement(410762..411265)
/gene="TVP18"
/locus_tag="YMR071C"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:16107716]"
/experiment="EXISTENCE:direct assay:GO:0030136
clathrin-coated vesicle [PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0016192
vesicle-mediated transport [PMID:17178117]"
/note="Integral membrane protein; localized to late Golgi
vesicles along with the v-SNARE Tlg2p; may interact with
ribosomes, based on co-purification experiments; may have
a role in intracellular sterol transport"
/codon_start=1
/product="Tvp18p"
/protein_id="NP_013787.1"
/db_xref="GeneID:855093"
/db_xref="SGD:S000004675"
/translation="MALSLGQFINVGGMVKDLKSFNFSVYGRWFGYINIILCIALGIA
NLFHVSGVIAFGIISIIQGLVILFIEIPFLLKICPLSDNFIEFIKRFETNGWRCLFYL
AMAIIQYISIAVMATSLIVVAVGLTISSISYAVAYTKHQEFQNTNIIKNPTDDDFPHE
AVVREML"
gene <411569..>412120
/gene="ABF2"
/locus_tag="YMR072W"
/db_xref="GeneID:855094"
mRNA <411569..>412120
/gene="ABF2"
/locus_tag="YMR072W"
/product="DNA-binding protein ABF2"
/transcript_id="NM_001182570.1"
/db_xref="GeneID:855094"
CDS 411569..412120
/gene="ABF2"
/locus_tag="YMR072W"
/experiment="EXISTENCE:direct assay:GO:0000262
mitochondrial chromosome [PMID:9581629]"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:27449618|PMID:9581629]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0008301 DNA
binding, bending [PMID:1737790]"
/experiment="EXISTENCE:direct assay:GO:0042645
mitochondrial nucleoid [PMID:10869431|PMID:27371858]"
/experiment="EXISTENCE:mutant phenotype:GO:0000001
mitochondrion inheritance [PMID:9581629]"
/experiment="EXISTENCE:mutant phenotype:GO:0000002
mitochondrial genome maintenance [PMID:9581629]"
/experiment="EXISTENCE:mutant phenotype:GO:0090139
mitochondrial chromosome packaging [PMID:21282901]"
/note="Mitochondrial DNA-binding protein; involved in
mitochondrial DNA replication and recombination, member of
HMG1 DNA-binding protein family; activity may be regulated
by protein kinase A phosphorylation; ABF2 has a paralog,
IXR1, that arose from the whole genome duplication; human
homolog TFAM can complement yeast abf2 mutant, rescuing
the loss-of-mitochondrial DNA phenotype"
/codon_start=1
/product="DNA-binding protein ABF2"
/protein_id="NP_013788.1"
/db_xref="GeneID:855094"
/db_xref="SGD:S000004676"
/translation="MNSYSLLTRSFHESSKPLFNLASTLLKASKRTQLRNELIKQGPK
RPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSE
YQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQS
IKDKYIQEYKKAIQEYNARYPLN"
gene complement(<412268..>412873)
/gene="IRC21"
/locus_tag="YMR073C"
/db_xref="GeneID:855095"
mRNA complement(<412268..>412873)
/gene="IRC21"
/locus_tag="YMR073C"
/product="Irc21p"
/transcript_id="NM_001182571.1"
/db_xref="GeneID:855095"
CDS complement(412268..412873)
/gene="IRC21"
/locus_tag="YMR073C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0006974 DNA
damage response [PMID:23273983]"
/experiment="EXISTENCE:mutant phenotype:GO:0009410
response to xenobiotic stimulus [PMID:16121259]"
/note="hypothetical protein; may be involved in resistance
to carboplatin and cisplatin; null mutant displays
increase in spontaneous Rad52p foci; contains a
lipid-binding domain and binds cardiolipin in a
large-scale study"
/codon_start=1
/product="Irc21p"
/protein_id="NP_013789.1"
/db_xref="GeneID:855095"
/db_xref="SGD:S000004677"
/translation="MSSDGMNRDVSNSKPNVRFAAPQRLSVAHPAISSPLHMPMSKSS
RKPLVRTKIRLDPGHSALDWHSLTSNPANYYTKFVSLQLIQDLLDDPVFQKDNFKFSP
SQLKNQLLVQKIPLYKIMPPLRINRKIVKKHCKGEDELWCVINGKVYDISSYLKFHPG
GTDILIKHRNSDDLITYFNKYHQWVNYEKLLQVCFIGVVCE"
gene complement(<413036..>413473)
/gene="SDD2"
/locus_tag="YMR074C"
/db_xref="GeneID:855096"
mRNA complement(<413036..>413473)
/gene="SDD2"
/locus_tag="YMR074C"
/product="Sdd2p"
/transcript_id="NM_001182572.1"
/db_xref="GeneID:855096"
CDS complement(413036..413473)
/gene="SDD2"
/locus_tag="YMR074C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0006915
apoptotic process [PMID:19469552]"
/note="Protein with homology to human PDCD5; PDCD5 is
involved in programmed cell death; N-terminal region forms
a conserved triple-helix bundle structure; overproduction
suppresses lethality due to expression of the dominant
PET9 allele AAC2-A128P; overexpression promotes
H2O2-induced apoptosis; YMR074C is not an essential gene;
protein abundance increases in response to DNA replication
stress"
/codon_start=1
/product="Sdd2p"
/protein_id="NP_013790.1"
/db_xref="GeneID:855096"
/db_xref="SGD:S000004678"
/translation="MDPELQAIREARLAQLKNNSGGTNGDRNSGANNGGGENSAPVGA
AIANFLEPQALERLSRVALVRRDRAQAVETYLKKLIATNNVTHKITEAEIVSILNGIA
KQQNSQNNSKIIFERKDFSEDLNSFDKQNAKNDDDEDDDDFFD"
gene <413982..>416036
/gene="RCO1"
/locus_tag="YMR075W"
/db_xref="GeneID:855097"
mRNA <413982..>416036
/gene="RCO1"
/locus_tag="YMR075W"
/product="Rco1p"
/transcript_id="NM_001182574.1"
/db_xref="GeneID:855097"
CDS 413982..416036
/gene="RCO1"
/locus_tag="YMR075W"
/experiment="EXISTENCE:direct assay:GO:0000118 histone
deacetylase complex [PMID:16286008]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S
complex [PMID:16286007|PMID:16286008]"
/experiment="EXISTENCE:genetic interaction:GO:0006368
transcription elongation by RNA polymerase II
[PMID:19948887]"
/experiment="EXISTENCE:mutant phenotype:GO:0030174
regulation of DNA-templated DNA replication initiation
[PMID:19417103]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:24358376]"
/experiment="EXISTENCE:mutant phenotype:GO:0060195
negative regulation of antisense RNA transcription
[PMID:21248844]"
/note="Essential component of the Rpd3S histone
deacetylase complex; interacts with Eaf3p"
/codon_start=1
/product="Rco1p"
/protein_id="NP_013791.1"
/db_xref="GeneID:855097"
/db_xref="SGD:S000004680"
/translation="MDTSKKDTTRSPSHSNSSSPSSSSLSSSSSKEKKRPKRLSSQNV
NYDLKRRKIITSEGIERSFKNEHSNLAVEDNIPEEEPKELLEKDSKGNIIKLNEPSTI
SEDSKVSVTGLPLNKGPSEKIKRESLWNYRKNLGGQSNNSEMTLVPSKRFTQVPKNFQ
DLNRNDLKTFLTENMTEESNIRSTIGWNGDIINRTRDREPESDRDNKKLSNIRTKIIL
STNATYDSKSKLFGQNSIKSTSNASEKIFRDKNNSTIDFENEDFCSACNQSGSFLCCD
TCPKSFHFLCLDPPIDPNNLPKGDWHCNECKFKIFINNSMATLKKIESNFIKQNNNVK
IFAKLLFNIDSHNPKQFQLPNYIKETFPAVKTGSRGQYSDENDKIPLTDRQLFNTSYG
QSITKLDSYNPDTHIDSNSGKFLICYKCNQTRLGSWSHPENSRLIMTCDYCQTPWHLD
CVPRASFKNLGSKWKCPLHSPTKVYKKIHHCQEDNSVNYKVWKKQRLINKKNQLYYEP
LQKIGYQNNGNIQIIPTTSHTDYDFNQDFKITQIDENSIKYDFFDKIYKSKMVQKRKL
FQFQESLIDKLVSNGSQNGNSEDNMVKDIASLIYFQVSNNDKSSNNKSASKSNNLRKL
WDLKELTNVVVPNELDSIQFNDFSSDEIKHLLYLKKIIESKPKEELLKFLNIENPENQ
SE"
gene complement(<415688..>416053)
/locus_tag="YMR075C-A"
/db_xref="GeneID:855098"
mRNA complement(<415688..>416053)
/locus_tag="YMR075C-A"
/product="uncharacterized protein"
/transcript_id="NM_001395040.1"
/db_xref="GeneID:855098"
CDS complement(415688..416053)
/locus_tag="YMR075C-A"
/note="hypothetical protein; almost completely overlaps
verified ORF RCO1/YMR075W"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001381970.1"
/db_xref="GeneID:855098"
/db_xref="SGD:S000004679"
/translation="MYVRRFYSDWFSGFSMFKNFNSSSFGLDSIIFFKYNRCFISSLE
KSLNCIESSSFGTTTLVSSFKSHNFLKLLLLEADLLLLLLSLLLTWKYIKEAMSLTIL
SSLLPFWDPFDTNLSIKLS"
gene complement(<416196..>420029)
/gene="PDS5"
/locus_tag="YMR076C"
/db_xref="GeneID:855099"
mRNA complement(<416196..>420029)
/gene="PDS5"
/locus_tag="YMR076C"
/product="Pds5p"
/transcript_id="NM_001182575.1"
/db_xref="GeneID:855099"
CDS complement(416196..420029)
/gene="PDS5"
/locus_tag="YMR076C"
/experiment="EXISTENCE:direct assay:GO:0000794 condensed
nuclear chromosome [PMID:11062262]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922|PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0035808 meiotic
recombination initiation complex [PMID:31617566]"
/experiment="EXISTENCE:mutant phenotype:GO:0005198
structural molecule activity [PMID:11137006]"
/experiment="EXISTENCE:mutant phenotype:GO:0006302
double-strand break repair [PMID:11448778|PMID:19736318]"
/experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic
sister chromatid cohesion [PMID:11062262|PMID:14623866]"
/experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic
chromosome condensation [PMID:11062262]"
/experiment="EXISTENCE:mutant phenotype:GO:0007129
homologous chromosome pairing at meiosis [PMID:19736318]"
/experiment="EXISTENCE:mutant phenotype:GO:0007130
synaptonemal complex assembly [PMID:35102525]"
/experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic
DNA double-strand break formation [PMID:31617566]"
/experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic
cell cycle [PMID:15819623]"
/experiment="EXISTENCE:mutant phenotype:GO:0140588
chromatin looping [PMID:32032532]"
/note="Cohesion maintenance factor; involved in sister
chromatid condensation and cohesion; colocalizes with
cohesin on chromosomes; performs its cohesin maintenance
function in pre-anaphase cells by protecting the integrity
of the cohesion complex; regulates homolog pairing and
facilitates synaptonemal complex formation, axis
formation, interhomolog recombination and synapsis during
meiosis; relocalizes to the cytosol in response to
hypoxia; scaffolding protein contains 26 HEAT repeats"
/codon_start=1
/product="Pds5p"
/protein_id="NP_013793.1"
/db_xref="GeneID:855099"
/db_xref="SGD:S000004681"
/translation="MAKGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQ
DNTDLTGLDKYRDALVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIF
KLVLSQFEQLGDQENGYHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPN
KSFPARLFNVIGGILGEVISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYE
VSLILCDTYSNRMSRHLTKYYSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPEL
INAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADIS
PDVRVEWTESIPQIIATREDISKELNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWK
NITNKAIYTSLLHLAREKHKEVRELCINTMAKFYSNSLNEIERTYQNKEIWEIIDTIP
STLYNLYYINDLNINEQVDSVIFEYLLPFEPDNDKRVHRLLTVLSHFDKKAFTSFFAF
NARQIKISFAISKYIDFSKFLNNQESMSSSQGPIVMNKYNQTLQWLASGLSDSTKAID
ALETIKQFNDERIFYLLNACVTNDIPFLTFKNCYNELVSKLQTPGLFKKYNISTGASI
MPRDIAKVIQILLFRASPIIYNVSNISVLLNLSNNSDAKQLDLKRRILDDISKVNPTL
FKDQIRTLKTIIKDLDDPDAEKNDNLSLEEALKTLYKASKTLKDQVDFDDTFFFTKLY
DFAVESKPEITKYATKLIALSPKAEETLKKIKIRILPLDLQKDKYFTSHIIVLMEIFK
KFPHVLNDDSTDIISYLIKEVLLSNQVVGDSKKEIDWVEDSLLSDTKYSAIGNKVFTL
KLFTNKLRSIAPDVPRDELAESFTEKTMKLFFYLIASGGELISEFNKEFYPTPSNYQT
KLRCVAGIQVLKLARISNLNNFIKPSDIIKLINLVEDESLPVRKTFLEQLKDYVANEL
ISIKFLPLVFFTAYEPDVELKTTTKIWINFTFGLKSFKKGTIFERALPRLIHAIAHHP
DIVGGLDSEGDAYLNALTTAIDYLLFYFDSIAAQENFSLLYYLSERVKNYQDKLVEDE
IDEEEGPQKEEAPKKHRPYGQKMYIIGELSQMILLNLKEKKNWQHSAYPGKLNLPSDL
FKPFATVQEAQLSFKTYIPESLTEKIQNNIKAKIGRILHTSQTQRQRLQKRLLAHENN
ESQKKKKKVHHARSQADDEEGDGDRESDSDDDSYSPSNKNETKKGHENIVMKKLRVRK
EVDYKDDEDDDIEMT"
gene complement(420588..420661)
/locus_tag="YNCM0023C"
/db_xref="GeneID:855100"
tRNA complement(420588..420661)
/locus_tag="YNCM0023C"
/product="tRNA-Val"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Valine tRNA (tRNA-Val), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:855100"
/db_xref="SGD:S000006764"
gene complement(<421484..>422149)
/gene="VPS20"
/locus_tag="YMR077C"
/gene_synonym="CHM6; VPL10; VPT20"
/db_xref="GeneID:855101"
mRNA complement(<421484..>422149)
/gene="VPS20"
/locus_tag="YMR077C"
/gene_synonym="CHM6; VPL10; VPT20"
/product="ESCRT-III subunit protein VPS20"
/transcript_id="NM_001182576.1"
/db_xref="GeneID:855101"
CDS complement(421484..422149)
/gene="VPS20"
/locus_tag="YMR077C"
/gene_synonym="CHM6; VPL10; VPT20"
/experiment="EXISTENCE:direct assay:GO:0000815 ESCRT III
complex [PMID:12194857]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:12194857]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:31273031]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0070676
intralumenal vesicle formation [PMID:23444383]"
/experiment="EXISTENCE:mutant phenotype:GO:0045324 late
endosome to vacuole transport [PMID:12953057]"
/experiment="EXISTENCE:mutant phenotype:GO:0070676
intralumenal vesicle formation [PMID:19234443]"
/experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP
export [PMID:26585826]"
/experiment="EXISTENCE:physical interaction:GO:0005515
protein binding [PMID:15086794]"
/note="Myristoylated subunit of the ESCRT-III complex; the
endosomal sorting complex required for transport of
transmembrane proteins into the multivesicular body
pathway to the lysosomal/vacuolar lumen; cytoplasmic
protein recruited to endosomal membranes"
/codon_start=1
/product="ESCRT-III subunit protein VPS20"
/protein_id="NP_013794.1"
/db_xref="GeneID:855101"
/db_xref="SGD:S000004682"
/translation="MGQKSSKVHITKTDRAILEVKRSKDEIHKFTRRTDNLILVEKSQ
LKDLIRKNPENYKSNMKVRFLLKRIHYQEHLLQQASDQLINLENMVSTLEFKMVEKQF
INGLKNGNEILKKLNKEFSNVDELMDDVQDQIAYQNEINETLSRSLVGTSNYEDDLDK
ELDALESELNPEKMNNAKVANMPSTEGLPSLPQGEQTEQKEREEFATEERSDTKEPLA
LLS"
gene complement(<422503..>424728)
/gene="CTF18"
/locus_tag="YMR078C"
/gene_synonym="CHL12"
/db_xref="GeneID:855102"
mRNA complement(<422503..>424728)
/gene="CTF18"
/locus_tag="YMR078C"
/gene_synonym="CHL12"
/product="Ctf18p"
/transcript_id="NM_001182577.1"
/db_xref="GeneID:855102"
CDS complement(422503..424728)
/gene="CTF18"
/locus_tag="YMR078C"
/gene_synonym="CHL12"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0043596 nuclear
replication fork [PMID:16962805]"
/experiment="EXISTENCE:genetic interaction:GO:0007064
mitotic sister chromatid cohesion [PMID:17483413]"
/experiment="EXISTENCE:mutant phenotype:GO:0000724
double-strand break repair via homologous recombination
[PMID:17636314]"
/experiment="EXISTENCE:mutant phenotype:GO:0003689 DNA
clamp loader activity [PMID:32277910]"
/experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA
replication initiation [PMID:20980819]"
/experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic
sister chromatid cohesion [PMID:11287619|PMID:11389843]"
/experiment="EXISTENCE:mutant phenotype:GO:0034398
telomere tethering at nuclear periphery [PMID:16525505]"
/experiment="EXISTENCE:mutant phenotype:GO:0035753
maintenance of DNA trinucleotide repeats [PMID:21347277]"
/experiment="EXISTENCE:physical interaction:GO:0031390
Ctf18 RFC-like complex [PMID:11389843]"
/note="Subunit of a complex with Ctf8p; shares some
subunits with Replication Factor C and is required for
sister chromatid cohesion; may have overlapping functions
with Rad24p in the DNA damage replication checkpoint"
/codon_start=1
/product="Ctf18p"
/protein_id="NP_013795.1"
/db_xref="GeneID:855102"
/db_xref="SGD:S000004683"
/translation="MVDTAPYIGSLGRSSLFDTGDIEQAPGNNAIGINEEDIHAFVSS
TGETVQLKKKPAKLATGNISLYTNPDTVWRSDDTYGININYLLDKIEASGDDRTNAQK
TSPITGKIGSDTLWVEKWRPKKFLDLVGNEKTNRRMLGWLRQWTPAVFKEQLPKLPTE
KEVSDMELDPLKRPPKKILLLHGPPGIGKTSVAHVIAKQSGFSVSEINASDERAGPMV
KEKIYNLLFNHTFDTNPVCLVADEIDGSIESGFIRILVDIMQSDIKATNKLLYGQPDK
KDKKRKKKRSKLLTRPIICICNNLYAPSLEKLKPFCEIIAVKRPSDTTLLERLNLICH
KENMNIPIKAINDLIDLAQGDVRNCINNLQFLASNVDSRDSSASDKPACAKNTWASSN
KDSPISWFKIVNQLFRKDPHRDIKEQFYELLNQVELNGNSDRILQGCFNIFPYVKYSD
NGIRKPANISDWLFFHDLMYQSMYAHNGELLRYSALVPLVFFQTFGDIANKDDIRMKN
SEYEQRELKRANSDIVSLIMRHISVQSPLMASFTDRKSLIFEILPYLDSMISSDFNKI
RNLKLKQAIMEELVQLLKSFQLNLIQNRSEGFDVRGGLTIDPPIDEVVLLNPKHINEV
QHKRANNLSSLLAKIEENRAKKRHIDQVTEDRLQSQEMHSKKVKTGLNSSSSTIDFFK
NQYGLLKQTQELEETQKTIGSDETNQADDCNQTVKIWVKYNEGFSNAVRKNVTWNNLW
E"
gene <424989..>426059
/gene="SEC14"
/locus_tag="YMR079W"
/gene_synonym="PIT1"
/db_xref="GeneID:855103"
mRNA join(<424989..424997,425154..>426059)
/gene="SEC14"
/locus_tag="YMR079W"
/gene_synonym="PIT1"
/product="phosphatidylinositol/phosphatidylcholine
transfer protein SEC14"
/transcript_id="NM_001182578.1"
/db_xref="GeneID:855103"
CDS join(424989..424997,425154..426059)
/gene="SEC14"
/locus_tag="YMR079W"
/gene_synonym="PIT1"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:7816798]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:1997207]"
/experiment="EXISTENCE:direct assay:GO:0005794 Golgi
apparatus [PMID:1997207]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:12869188|PMID:2466847|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0008525
phosphatidylcholine transporter activity
[PMID:10488334|PMID:10848624|PMID:2407740]"
/experiment="EXISTENCE:direct assay:GO:0008526
phosphatidylinositol transfer activity
[PMID:10848624|PMID:2407740|PMID:2215682]"
/experiment="EXISTENCE:direct assay:GO:0015914
phospholipid transport
[PMID:10848624|PMID:2407740|PMID:2215682]"
/experiment="EXISTENCE:direct assay:GO:0048194 Golgi
vesicle budding [PMID:9553090|PMID:9736710]"
/experiment="EXISTENCE:direct assay:GO:2001246 negative
regulation of phosphatidylcholine biosynthetic process
[PMID:7816798]"
/experiment="EXISTENCE:genetic interaction:GO:0006896
Golgi to vacuole transport [PMID:18753406]"
/experiment="EXISTENCE:genetic interaction:GO:0046488
phosphatidylinositol metabolic process [PMID:10567405]"
/experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi
to vacuole transport [PMID:18753406]"
/experiment="EXISTENCE:mutant phenotype:GO:0008525
phosphatidylcholine transporter activity [PMID:10488334]"
/experiment="EXISTENCE:mutant phenotype:GO:0008526
phosphatidylinositol transfer activity
[PMID:10848624|PMID:2215682]"
/experiment="EXISTENCE:mutant phenotype:GO:0015914
phospholipid transport [PMID:2215682]"
/experiment="EXISTENCE:mutant phenotype:GO:0030437
ascospore formation [PMID:14528019]"
/experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi
to plasma membrane protein transport
[PMID:10848624|PMID:19129178|PMID:6754086]"
/experiment="EXISTENCE:mutant phenotype:GO:0046488
phosphatidylinositol metabolic process [PMID:10567405]"
/experiment="EXISTENCE:mutant phenotype:GO:1901352
negative regulation of phosphatidylglycerol biosynthetic
process [PMID:12869188]"
/experiment="EXISTENCE:mutant phenotype:GO:2001246
negative regulation of phosphatidylcholine biosynthetic
process [PMID:7816798]"
/note="Phosphatidylinositol/phosphatidylcholine transfer
protein; involved in regulating PtdIns, PtdCho, and
ceramide metabolism, products of which regulate
intracellular transport and UPR; has a role in
localization of lipid raft proteins; functionally
homologous to mammalian PITPs; SEC14 has a paralog,
YKL091C, that arose from the whole genome duplication"
/codon_start=1
/product="phosphatidylinositol/phosphatidylcholine
transfer protein SEC14"
/protein_id="NP_013796.1"
/db_xref="GeneID:855103"
/db_xref="SGD:S000004684"
/translation="MVTQQEKEFLESYPQNCPPDALPGTPGNLDSAQEKALAELRKLL
EDAGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKWRKDYGTDTILQDFHYDEKPL
IAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLVWEYESVVQYRLP
ACSRAAGHLVETSCTIMDLKGISISSAYSVMSYVREASYISQNYYPERMGKFYIINAP
FGFSTAFRLFKPFLDPVTVSKIFILGSSYQKELLKQIPAENLPVKFGGKSEVDESKGG
LYLSDIGPWRDPKYIGPEGEAPEAFSMK"
gene complement(<426712..>429627)
/gene="NAM7"
/locus_tag="YMR080C"
/gene_synonym="IFS2; MOF4; SUP113; SUT2; UPF1"
/db_xref="GeneID:855104"
mRNA complement(<426712..>429627)
/gene="NAM7"
/locus_tag="YMR080C"
/gene_synonym="IFS2; MOF4; SUP113; SUT2; UPF1"
/product="ATP-dependent RNA helicase NAM7"
/transcript_id="NM_001182579.1"
/db_xref="GeneID:855104"
CDS complement(426712..429627)
/gene="NAM7"
/locus_tag="YMR080C"
/gene_synonym="IFS2; MOF4; SUP113; SUT2; UPF1"
/EC_number="3.6.4.12"
/EC_number="3.6.4.13"
/experiment="EXISTENCE:direct assay:GO:0003724 RNA
helicase activity [PMID:8816462]"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005844 polysome
[PMID:7545033]"
/experiment="EXISTENCE:direct assay:GO:0016567 protein
ubiquitination [PMID:18676617]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:8816461|PMID:8816462]"
/experiment="EXISTENCE:direct assay:GO:0043024 ribosomal
small subunit binding [PMID:23801788]"
/experiment="EXISTENCE:genetic interaction:GO:0030466
silent mating-type cassette heterochromatin formation
[PMID:16157874]"
/experiment="EXISTENCE:genetic interaction:GO:0070478
nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated decay
[PMID:12769863|PMID:12881429]"
/experiment="EXISTENCE:mutant phenotype:GO:0000184
nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay [PMID:8816461|PMID:8816462]"
/experiment="EXISTENCE:mutant phenotype:GO:0000956
nuclear-transcribed mRNA catabolic process
[PMID:16285926]"
/experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA
recombination [PMID:23390378]"
/experiment="EXISTENCE:mutant phenotype:GO:0006449
regulation of translational termination [PMID:8816461]"
/experiment="EXISTENCE:mutant phenotype:GO:0008298
intracellular mRNA localization [PMID:16777600]"
/experiment="EXISTENCE:mutant phenotype:GO:0016567 protein
ubiquitination [PMID:18676617]"
/experiment="EXISTENCE:mutant phenotype:GO:0070478
nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated decay [PMID:12881429]"
/experiment="EXISTENCE:physical interaction:GO:0016567
protein ubiquitination [PMID:18676617]"
/note="ATP-dependent RNA helicase of the SFI superfamily;
involved in nonsense mediated mRNA decay; required for
efficient translation termination at nonsense codons and
targeting of NMD substrates to P-bodies; binds to the
small ribosomal subunit via an interaction with Rps26;
forms cytoplasmic foci upon DNA replication stress"
/codon_start=1
/product="ATP-dependent RNA helicase NAM7"
/protein_id="NP_013797.1"
/db_xref="GeneID:855104"
/db_xref="SGD:S000004685"
/translation="MVGSGSHTPYDISNSPSDVNVQPATQLNSTLVEDDDVDNQLFEE
AQVTETGFRSPSASDNSCAYCGIDSAKCVIKCNSCKKWFCNTKNGTSSSHIVNHLVLS
HHNVVSLHPDSDLGDTVLECYNCGRKNVFLLGFVSAKSEAVVVLLCRIPCAQTKNANW
DTDQWQPLIEDRQLLSWVAEQPTEEEKLKARLITPSQISKLEAKWRSNKDATINDIDA
PEEQEAIPPLLLRYQDAYEYQRSYGPLIKLEADYDKQLKESQALEHISVSWSLALNNR
HLASFTLSTFESNELKVAIGDEMILWYSGMQHPDWEGRGYIVRLPNSFQDTFTLELKP
SKTPPPTHLTTGFTAEFIWKGTSYDRMQDALKKFAIDKKSISGYLYYKILGHQVVDIS
FDVPLPKEFSIPNFAQLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKI
HKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSVSNLALHNLVGRGAK
GELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRLDTKF
RTVLIDESTQASEPECLIPIVKGAKQVILVGDHQQLGPVILERKAADAGLKQSLFERL
ISLGHVPIRLEVQYRMNPYLSEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGIPM
MFWANYGREEISANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYIL
QYMQMNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRRLNVG
LTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGTLDNLQLCTVQLVRPQPRK
TERPMNAQFNVESEMGDFPKFQDFDAQSMVSFSGQIGDFGNAFVDNTELSSYINNEYW
NFENFKSAFSQKQNRNEIDDRNLYQEEASHLNSNFARELQREEQKHELSKDFSNLGI"
gene complement(<430079..>431095)
/gene="ISF1"
/locus_tag="YMR081C"
/gene_synonym="MBR3"
/db_xref="GeneID:855105"
mRNA complement(<430079..>431095)
/gene="ISF1"
/locus_tag="YMR081C"
/gene_synonym="MBR3"
/product="Isf1p"
/transcript_id="NM_001182580.1"
/db_xref="GeneID:855105"
CDS complement(430079..431095)
/gene="ISF1"
/locus_tag="YMR081C"
/gene_synonym="MBR3"
/experiment="EXISTENCE:genetic interaction:GO:0009060
aerobic respiration [PMID:8208248]"
/note="Serine-rich, hydrophilic protein; overexpression
suppresses growth defects of hap2, hap3, and hap4 mutants;
expression is under glucose control; cotranscribed with
NAM7 in a cyp1 mutant; ISF1 has a paralog, MBR1, that
arose from the whole genome duplication"
/codon_start=1
/product="Isf1p"
/protein_id="NP_013798.1"
/db_xref="GeneID:855105"
/db_xref="SGD:S000004686"
/translation="MIASEIFERGVQDPFCQDCDYEDETDVQSFLGSNDLNDFVNSKL
ASFSFQNSSKSNNSHHSSSTNAGNTSRHIGNHTIGHHLRKIKTAPHHLYGFVPANSTN
NSNEPIRPSPRRIRANSSTLIHQLSRQSTRQSSLGDAADSCFDHKCIKPRSRHSSCYG
IPTHLYGLEKYVSSELDSLAVANDQSNDLTSPLTSVSTPASNSNSYLNLNSSSAAYPS
SYLSNEKNNRLKLISHGKISSNNVPGHSGNLNHYHRERTPSNLRRESFSLLSNGSSSS
PLQTRNNSYSNSLVKSPSNSSLNTSVASSNEESSPHTSNCLEERNPRRKSFIKLSLAS
SFSN"
gene complement(<431769..>432125)
/locus_tag="YMR082C"
/db_xref="GeneID:855106"
mRNA complement(<431769..>432125)
/locus_tag="YMR082C"
/product="uncharacterized protein"
/transcript_id="NM_001348865.1"
/db_xref="GeneID:855106"
CDS complement(431769..432125)
/locus_tag="YMR082C"
/note="hypothetical protein; conserved among S. cerevisiae
strains; YMR082C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335805.1"
/db_xref="GeneID:855106"
/db_xref="SGD:S000004687"
/translation="MTIAEITIRQKFSYPFLFGNVLGHPWPRNVPRKEIKMLLFRTAN
NSFPGFLLIFTRKRRNLPKQRDNEIPRTRALETYLRVFSAARKQREADATASFWRLVT
SASRSHYHMWPIKRII"
gene <434788..>435915
/gene="ADH3"
/locus_tag="YMR083W"
/db_xref="GeneID:855107"
mRNA <434788..>435915
/gene="ADH3"
/locus_tag="YMR083W"
/product="alcohol dehydrogenase ADH3"
/transcript_id="NM_001182582.1"
/db_xref="GeneID:855107"
CDS 434788..435915
/gene="ADH3"
/locus_tag="YMR083W"
/EC_number="1.1.1.1"
/experiment="EXISTENCE:direct assay:GO:0004022 alcohol
dehydrogenase (NAD+) activity [PMID:3550419]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:3550419]"
/experiment="EXISTENCE:direct assay:GO:0006116 NADH
oxidation [PMID:3546317]"
/experiment="EXISTENCE:genetic interaction:GO:0000947
amino acid catabolic process to alcohol via Ehrlich
pathway [PMID:12499363]"
/note="Mitochondrial alcohol dehydrogenase isozyme III;
involved in the shuttling of mitochondrial NADH to the
cytosol under anaerobic conditions and ethanol production"
/codon_start=1
/product="alcohol dehydrogenase ADH3"
/protein_id="NP_013800.1"
/db_xref="GeneID:855107"
/db_xref="SGD:S000004688"
/translation="MLRTSTLFTRRVQPSLFSRNILRLQSTAAIPKTQKGVIFYENKG
KLHYKDIPVPEPKPNEILINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVK
LGSNVKGWKVGDLAGIKWLNGSCMTCEFCESGHESNCPDADLSGYTHDGSFQQFATAD
AIQAAKIQQGTDLAEVAPILCAGVTVYKALKEADLKAGDWVAISGAAGGLGSLAVQYA
TAMGYRVLGIDAGEEKEKLFKKLGGEVFIDFTKTKNMVSDIQEATKGGPHGVINVSVS
EAAISLSTEYVRPCGTVVLVGLPANAYVKSEVFSHVVKSINIKGSYVGNRADTREALD
FFSRGLIKSPIKIVGLSELPKVYDLMEKGKILGRYVVDTSK"
gene <436628..>437416
/locus_tag="YMR084W"
/db_xref="GeneID:855108"
mRNA <436628..>437416
/locus_tag="YMR084W"
/product="putative glutamine--fructose-6-phosphate
transaminase"
/transcript_id="NM_001182583.1"
/db_xref="GeneID:855108"
CDS 436628..437416
/locus_tag="YMR084W"
/EC_number="2.6.1.16"
/note="hypothetical protein; YMR084W and adjacent ORF
YMR085W are merged in related strains, and together are
paralogous to glutamine-fructose-6-phosphate
amidotransferase GFA1"
/codon_start=1
/product="putative glutamine--fructose-6-phosphate
transaminase"
/protein_id="NP_013801.1"
/db_xref="GeneID:855108"
/db_xref="SGD:S000004689"
/translation="MCGIFGYCNFLIEKTRGEIIDTLIEGLQALEYKEYDSSGISIQG
DELESLNIYKQTGKISSLKEEIDLYNLNKNLPFISHCGIAHTRRATHGGLRRANCHPH
NSDPSNEFVVVHNGVITNFANLKALLMAKGYVFKSDTDTECIPKLYKHIYDTSIELGY
NLDFHVLTNLVLKELEGSYGLLCTSSHFPDEVVAARKGSPLVIGVKGKTDMDVNFVEV
EYLDQEEDYLKLNTQTKSSGNVLAAAPVKYNTCLRKSPPFVHNT"
gene <437491..>438789
/locus_tag="YMR085W"
/db_xref="GeneID:855109"
mRNA <437491..>438789
/locus_tag="YMR085W"
/product="uncharacterized protein"
/transcript_id="NM_001182584.1"
/db_xref="GeneID:855109"
CDS 437491..438789
/locus_tag="YMR085W"
/note="hypothetical protein; YMR085W and adjacent ORF
YMR084W are merged in related strains, and together are
paralogous to glutamine-fructose-6-phosphate
amidotransferase GFA1"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013802.1"
/db_xref="GeneID:855109"
/db_xref="SGD:S000004690"
/translation="MEFYLSSDCASLARYVSKVVYLEDNDIAHIYDGELHIHCSKIGS
EDFSFRTVQKLELELSKIKKGPYDNFMQKEIYEQCETTKNVMRGRVDAFTNRVVLGGL
ENWLTELRRAKRIIMIASKASFHSCLAARPIFEELMEVPVNVELALDFVDRNCCIFRN
DVCIFVSRSGETTDTINALNYCIKKEAVTIGVVNCSGSSISRFTHCGVHTNTGPEKGI
ATTKSYTSQYIALVMIALWMSEDLVSKIERRKEIIQALTIVPSQIKEVLELEPLIIEL
CDKKLKQHDTFLLLGRGYQFASALEGASKMKEISYVHSESILTNELGHRVLAVASDNP
PIIAFATKDAFSPKIASCIDQIIERKGNPIIICNKGHKIWEQDKQKGNVVTLEVPQTV
DCLQGILNVIPLQLISYWLAIKKDIGVDLPRDSAMSAPDI"
gene <439208..>442090
/gene="SEG1"
/locus_tag="YMR086W"
/db_xref="GeneID:855110"
mRNA <439208..>442090
/gene="SEG1"
/locus_tag="YMR086W"
/product="Seg1p"
/transcript_id="NM_001182586.1"
/db_xref="GeneID:855110"
CDS 439208..442090
/gene="SEG1"
/locus_tag="YMR086W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0032126 eisosome
[PMID:19269952|PMID:22869600]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0070941
eisosome assembly [PMID:22869600]"
/note="Component of eisosome required for proper eisosome
assembly; precedes Pil1p/Lsp1p during eisosome formation,
controls eisosome length and shape; diffusely distributed,
forms heterogeneous patches at plasma membrane in small
buds, also found in medium and large buds; expression
repressed by cAMP; similar to A. gossypii SEG gene and to
S. pombe Sle1p, important for generating eisosomes; SEG1
has a paralog, SEG2, that arose from the whole genome
duplication"
/codon_start=1
/product="Seg1p"
/protein_id="NP_013803.1"
/db_xref="GeneID:855110"
/db_xref="SGD:S000004692"
/translation="MFRRRTTAPEMEQADPTAVAAAASIGKLLMKKGNQSDNEQRPTY
RSASMTNLRKPSAPKRMSSISSISSESRRSDGKGRPGKINSLTQRSSMGKGDSLNSPL
TKEPQHKTRSHNRTSSLPNQRGQQSRNSSGLQRQKSKTHQRISYDEAQRTFKDFGGPQ
ARGILTGQHRTENPSGSIPLRTTRKYIPGPNGLVAIEVPVEKPSNANTSKLLRRSNSA
HSALNARNGSLLRKKVSQESLHSQPKKTSSLGNTSSTQAKKGQKAVQERNLAKKHPIN
SNVPLIETQVREETDQELKLDNSNSSESETVVNSENNLEKPSSLNIEKDDLSKLIHEN
IELESFIEEKGKEKPLNSDQEDVFISEKTVKGDVQWPKNNRQASTLEKTFNYDNEEKR
EGNKPVAEHPLPEAEVDDKSVEQLNNISSSGSYSAQGSVENSKPENGNKNLENDTTSS
PTQDLDEKSRSIEEKDTLEGTESSKKVEKPDNCCEKISGANTSSKKGNVGDTKDEFFD
TVEESDQKTSKSNSSKNTDHSNQTEPTPSLAQYLRTSNTYLSRKNQSKQAEQEKFHKP
EAPMVPVTKVVTPIKSALKKSSGSSNHDSSMYSDNSPANGAYLSLTTAENTRLNAQMT
MSDSVSRRASLKRSSIKRPQSVGQFRSIRSNSPSPPEKINNKRHSAIPLGTPEKGKPK
RNSVMASLSKNSQQIQEPASVYESNGPNKPKNQINKNIKRGSQIAQNNKPSTKDMNSI
LYPKEPPPRKSSFEKTRSNESHLGFKKLSLRNGNFEEALSESYNGQASQNSTNVNRTD
TAQEFFKYLGHSSRFADSDSEDESQFFNQGPSKYNTETEGNKTSGNKNSNGGNGAFSL
FKSKSKQKENNVVSPGVSSPNHTTTDPAITSKKVDKKFSGLSLRAASEAEPAKNSNPS
MTNRLRFSSNPENGESRLPQAQEVSVTKEKKGSFGKKLKKIFGRKK"
gene <442527..>443381
/gene="PDL32"
/locus_tag="YMR087W"
/db_xref="GeneID:855112"
mRNA <442527..>443381
/gene="PDL32"
/locus_tag="YMR087W"
/product="putative ADP-ribose 1''-phosphate phosphatase"
/transcript_id="NM_001182587.1"
/db_xref="GeneID:855112"
CDS 442527..443381
/gene="PDL32"
/locus_tag="YMR087W"
/EC_number="3.1.3.84"
/note="Putative ADP-ribose-1''-monophosphatase; converts
ADP-ribose-1''-monophosphate to ADP-ribose; may have a
role in tRNA splicing; contains an A1pp domain"
/codon_start=1
/product="putative ADP-ribose 1''-phosphate phosphatase"
/protein_id="NP_013805.1"
/db_xref="GeneID:855112"
/db_xref="SGD:S000004693"
/translation="MTGSLNRHSLLNGVKKMRIILCDTNEVVTNLWQESIPHAYIQND
KYLCIHHGHLQSLMDSMRKGDAIHHGHSYAIVSPGNSYGYLGGGFDKALYNYFGGKPF
ETWFRNQLGGRYHTVGSATVVDLQRCLEEKTIECRDGIRYIIHVPTVVAPSAPIFNPQ
NPLKTGFEPVFNAMWNALMHSPKDIDGLIIPGLCTGYAGVPPIISCKSMAFALRLYMA
GDHISKELKNVLIMYYLQYPFEPFFPESCKIECQKLGIDIEMLKSFNVEKDAIELLIP
RRILTLDL"
gene complement(<443414..>445102)
/gene="VBA1"
/locus_tag="YMR088C"
/db_xref="GeneID:855113"
mRNA complement(<443414..>445102)
/gene="VBA1"
/locus_tag="YMR088C"
/product="Vba1p"
/transcript_id="NM_001182588.1"
/db_xref="GeneID:855113"
CDS complement(443414..445102)
/gene="VBA1"
/locus_tag="YMR088C"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:15572352|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0015174 basic amino
acid transmembrane transporter activity [PMID:15572352]"
/experiment="EXISTENCE:mutant phenotype:GO:0015174 basic
amino acid transmembrane transporter activity
[PMID:15572352]"
/experiment="EXISTENCE:mutant phenotype:GO:0015802 basic
amino acid transport [PMID:15572352]"
/note="Permease of basic amino acids in vacuolar membrane;
targeted to vacuole via AP-3 pathway"
/codon_start=1
/product="Vba1p"
/protein_id="NP_013806.1"
/db_xref="GeneID:855113"
/db_xref="SGD:S000004694"
/translation="MQTLDETSNLLPPPEEAEAPPLEQKFHEYNLALPKFPILFSLWL
GSFLSSLDSTIVANIMNRVAEEFSESSKKQWIATSFLLTNTAFQPLYGKLSDITGRKS
ALLTAQFFFGLGCLLTCFARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGV
YQGYANIVFGFGQLLGAPLGGVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHV
PPMKERYTLKNLSRIDIFGSLSLVATISGVLFLCSSQLNKLYLALFTIGSFIVFILVE
RYYATEKILPFELLTRSFCLSSAVTVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFL
IFPSISVAVGSLVTGWVLRNTKINLAHCAYQIIFGGMIMQLLGLGLGYFLLSHLNPDY
TIYDMLESITFRSNSIWWKLIYVFASVLVSFGYACLLVATLVSIVFTVEKSQQGTMTG
VFYLWRSIGNVLGASLTLVSYENSLSSMLWNYMFKTKRDDEYHFTKKQYYSLINDSSY
LRGPNFPTDIFVRILDVYKKAFLISYIPNIALAAVGIVLSLYLVKHTYKRSSSS"
gene complement(<445609..>448086)
/gene="YTA12"
/locus_tag="YMR089C"
/gene_synonym="RCA1"
/db_xref="GeneID:855114"
mRNA complement(<445609..>448086)
/gene="YTA12"
/locus_tag="YMR089C"
/gene_synonym="RCA1"
/product="m-AAA protease subunit YTA12"
/transcript_id="NM_001182589.1"
/db_xref="GeneID:855114"
CDS complement(445609..448086)
/gene="YTA12"
/locus_tag="YMR089C"
/gene_synonym="RCA1"
/experiment="EXISTENCE:direct assay:GO:0005524 ATP binding
[PMID:19748354]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:11914276|PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:7929327]"
/experiment="EXISTENCE:direct assay:GO:0005745 m-AAA
complex [PMID:8681382]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:19748354]"
/experiment="EXISTENCE:direct assay:GO:0097002
mitochondrial inner boundary membrane [PMID:19019989]"
/experiment="EXISTENCE:mutant phenotype:GO:0006465 signal
peptide processing [PMID:12417197]"
/experiment="EXISTENCE:mutant phenotype:GO:0008237
metallopeptidase activity [PMID:8681382]"
/experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP
hydrolysis activity [PMID:19748354]"
/experiment="EXISTENCE:mutant phenotype:GO:0065003
protein-containing complex assembly [PMID:8681382]"
/note="Mitochondrial inner membrane m-AAA protease
component; mediates degradation of misfolded or
unassembled proteins; also required for correct assembly
of mitochondrial enzyme complexes; overexpression of human
AFG3L2 complements respiratory defect of yeast afg3 yta12
double null mutation, but overexpression of
disease-associated AFG3L2 variants does not; expression of
both human SPG7 (paraplegin) and AFG3L2 complements yeast
yta12 afg3 double mutation"
/codon_start=1
/product="m-AAA protease subunit YTA12"
/protein_id="NP_013807.1"
/db_xref="GeneID:855114"
/db_xref="SGD:S000004695"
/translation="MLLLSWSRIATKVVRRPVRFRSYYGLTHIKSLHTQYRLLNRLQE
NKSGNKNEDNNEDAKLNKEIPTDEEVEAIRKQVEKYIEQTKNNTIPANWKEQKRKIDE
SIRRLEDAVLKQESNRIQEERKEKEEENGPSKAKSNRTKEQGYFEGNNSRNIPPPPPP
PPPKPPLNDPSNPVSKNVNLFQIGLTFFLLSFLLDLLNSLEEQSEITWQDFREKLLAK
GYVAKLIVVNKSMVKVMLNDNGKNQADNYGRNFYYFTIGSIDSFEHKLQKAQDELDID
KDFRIPVLYVQEGNWAKAMFQILPTVLMIAGIIWLTRRSAQAAGGSRGGIFGLSRSKA
KKFNTETDVKIKFKDVAGCDEAKEEIMEFVSFLKEPSRYEKMGAKIPRGAILSGPPGT
GKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARVRDLFKTARENAPSIVFIDEID
AIGKARQKGNFSGANDERENTLNQMLVEMDGFTPADHVVVLAGTNRPDILDKALLRPG
RFDRHINIDKPELEGRKAIFAVHLHHLKLAGEIFDLKNRLAALTPGFSGADIANVCNE
AALIAARSDEDAVKLNHFEQAIERVIGGVERKSKLLSPEEKKVVAYHEAGHAVCGWYL
KYADPLLKVSIIPRGQGALGYAQYLPGDIFLLTEQQLKDRMTMSLGGRVSEELHFPSV
TSGASDDFKKVTSMATAMVTELGMSDKIGWVNYQKRDDSDLTKPFSDETGDIIDSEVY
RIVQECHDRCTKLLKEKAEDVEKIAQVLLKKEVLTREDMIDLLGKRPFPERNDAFDKY
LNDYETEKIRKEEEKNEKRNEPKPSTN"
gene <449245..>449928
/locus_tag="YMR090W"
/db_xref="GeneID:855115"
mRNA <449245..>449928
/locus_tag="YMR090W"
/product="uncharacterized protein"
/transcript_id="NM_001182590.1"
/db_xref="GeneID:855115"
CDS 449245..449928
/locus_tag="YMR090W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="hypothetical protein; similar to DTDP-glucose
4,6-dehydratases; GFP-fusion protein localizes to the
cytoplasm; up-regulated in response to the fungicide
mancozeb; not essential for viability"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013808.1"
/db_xref="GeneID:855115"
/db_xref="SGD:S000004696"
/translation="MSPMKVAVVGASGKVGRLLINQLKANDSFSTPLAIVRTQDQVNY
FKNEVGVDASLTDIENASVSEITDAIKAYDAVVFSAGAGGKGMERIFTVDLDGCIKVV
EACEKAGIKRFVVVSALKAEDRDFWYNIKGLREYYIAKRSADREVRNSNLDYTILQPG
SLELNKGTGLLQPLDKLEEKASVNYSINREDVASFIVESLLHPNATVKKTISLVNGNE
PMEKFIQSL"
gene complement(<450058..>451365)
/gene="NPL6"
/locus_tag="YMR091C"
/gene_synonym="RSC7"
/db_xref="GeneID:855116"
mRNA complement(<450058..>451365)
/gene="NPL6"
/locus_tag="YMR091C"
/gene_synonym="RSC7"
/product="Npl6p"
/transcript_id="NM_001182591.1"
/db_xref="GeneID:855116"
CDS complement(450058..451365)
/gene="NPL6"
/locus_tag="YMR091C"
/gene_synonym="RSC7"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006337 nucleosome
disassembly [PMID:16492771]"
/experiment="EXISTENCE:direct assay:GO:0006338 chromatin
remodeling [PMID:12183366]"
/experiment="EXISTENCE:direct assay:GO:0006368
transcription elongation by RNA polymerase II
[PMID:17081996]"
/experiment="EXISTENCE:direct assay:GO:0016586 RSC-type
complex [PMID:10619019|PMID:12183366|PMID:14729968]"
/note="Component of the RSC chromatin remodeling complex;
interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a
module important for a broad range of RSC functions"
/codon_start=1
/product="Npl6p"
/protein_id="NP_013809.1"
/db_xref="GeneID:855116"
/db_xref="SGD:S000004697"
/translation="MSDSEGGLASEVEHEKRSRSTSNRPNYAIDTEDLDIDENDENED
DDYREEEANEGVNEEEISDEEEQINKSGRNKRRHVDEEEDLSEDKGVTRSRNRSKFKK
PVFPGIDDAEENLNPLKVVNEEYVLPDDPEGETKITADGDLLGGREFLVRTFTLTEKG
NRKFMLATEPARIVGFRDSYLFFQTHPNLYKFILNQTQKNDLIDRGVLPYSYRNRQIA
LVTARGVFKEFGAKIIRGGKHITDDYYASELRTKGNVIEGKLAGDPIDKSARALETMM
YPASENGINPAKNQVEFFEHRPHGHMSNSNIIASGSKLSSTNWLYQHSAACSRFNSDL
FYDRVKVLLVDQQGLRDAYTNILHIPESTQSTTVLGWRRSKNDSPSDTSIVYETVIHD
NDLNKPKTGLSEIPKEIYEDVVDEDVLRAITEQQNFEKCNEYI"
gene complement(<451632..>453479)
/gene="AIP1"
/locus_tag="YMR092C"
/db_xref="GeneID:855117"
mRNA complement(<451632..>453479)
/gene="AIP1"
/locus_tag="YMR092C"
/product="Aip1p"
/transcript_id="NM_001182592.1"
/db_xref="GeneID:855117"
CDS complement(451632..453479)
/gene="AIP1"
/locus_tag="YMR092C"
/experiment="EXISTENCE:direct assay:GO:0003779 actin
binding [PMID:10366597]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005884 actin
filament [PMID:23333351]"
/experiment="EXISTENCE:direct assay:GO:0030479 actin
cortical patch [PMID:10366597]"
/experiment="EXISTENCE:direct assay:GO:0043332 mating
projection tip [PMID:19053807]"
/experiment="EXISTENCE:genetic interaction:GO:0030042
actin filament depolymerization [PMID:10366597]"
/experiment="EXISTENCE:genetic interaction:GO:0032466
negative regulation of cytokinesis [PMID:25371407]"
/experiment="EXISTENCE:mutant phenotype:GO:0051016
barbed-end actin filament capping [PMID:23333351]"
/experiment="EXISTENCE:physical interaction:GO:0030042
actin filament depolymerization [PMID:10366597]"
/note="Actin cortical patch component; interacts with the
actin depolymerizing factor cofilin; inhibits elongation
of aged ADP-actin filaments decorated with cofilin to
maintain a high level of assembly-competent actin species;
required to restrict cofilin localization to cortical
patches; putative regulator of cytokinesis; contains WD
repeats; mutations in human homolog WDR1 are associated
with cardiac hypertrophy"
/codon_start=1
/product="Aip1p"
/protein_id="NP_013810.1"
/db_xref="GeneID:855117"
/db_xref="SGD:S000004698"
/translation="MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVR
CLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN
SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS
QRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDS
GEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI
RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKT
ISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWD
DTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGS
AVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDV
MGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIF
IYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNVVLE"
gene <454015..>455556
/gene="UTP15"
/locus_tag="YMR093W"
/db_xref="GeneID:855118"
mRNA <454015..>455556
/gene="UTP15"
/locus_tag="YMR093W"
/product="snoRNA-binding rRNA-processing protein UTP15"
/transcript_id="NM_001182593.1"
/db_xref="GeneID:855118"
CDS 454015..455556
/gene="UTP15"
/locus_tag="YMR093W"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:12068309]"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:12150911]"
/experiment="EXISTENCE:direct assay:GO:0032040
small-subunit processome [PMID:12068309]"
/experiment="EXISTENCE:direct assay:GO:0033553 rDNA
heterochromatin [PMID:15489292]"
/experiment="EXISTENCE:direct assay:GO:0034455 t-UTP
complex [PMID:17515605]"
/experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA
binding [PMID:12068309]"
/experiment="EXISTENCE:mutant phenotype:GO:0000462
maturation of SSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]"
/experiment="EXISTENCE:mutant phenotype:GO:0045943
positive regulation of transcription by RNA polymerase I
[PMID:15489292]"
/note="Nucleolar protein; component of the small subunit
(SSU) processome containing the U3 snoRNA that is involved
in processing of pre-18S rRNA"
/codon_start=1
/product="snoRNA-binding rRNA-processing protein UTP15"
/protein_id="NP_013811.1"
/db_xref="GeneID:855118"
/db_xref="SGD:S000004699"
/translation="MSTARPRIITSKAPLLPQQTTPEQRYWRQYTSAQLVKEHNSVTH
ISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDAT
GLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEP
QLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENV
IAVSPTQIVSCGGNNFKVWDLTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASS
LDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKK
EKRSSDKENAPASFNKNAKSNNFQRMMRGSEYQGDQEHIIHNDKVRSQRRMRAFERNI
NQFKWSEALDNAFVPGMAKELTLTVLQELRKRGKVRVALYGRDESTLEPLLNWCLKGI
EDVRSASIVADWVAVVLELYGNTLESSPVLQELMIDLKTKVRHEIHKSKEAQRIEGML
QLLTS"
gene <455825..>457261
/gene="CTF13"
/locus_tag="YMR094W"
/db_xref="GeneID:855119"
mRNA <455825..>457261
/gene="CTF13"
/locus_tag="YMR094W"
/product="Ctf13p"
/transcript_id="NM_001182594.1"
/db_xref="GeneID:855119"
CDS 455825..457261
/gene="CTF13"
/locus_tag="YMR094W"
/experiment="EXISTENCE:direct assay:GO:0008301 DNA
binding, bending [PMID:10097110]"
/experiment="EXISTENCE:direct assay:GO:0031518 CBF3
complex [PMID:1997204|PMID:8670864|PMID:8706132]"
/experiment="EXISTENCE:direct assay:GO:0051382 kinetochore
assembly [PMID:12084919]"
/experiment="EXISTENCE:mutant phenotype:GO:0000921 septin
ring assembly [PMID:16330709]"
/note="Subunit of the CBF3 complex; F-box protein of the
leucine-rich-repeat family; required for assembly of the
complex; CBF3 binds to the CDE III element of centromeres,
bending the DNA upon binding, and may be involved in
sister chromatid cohesion during mitosis"
/codon_start=1
/product="Ctf13p"
/protein_id="NP_013812.1"
/db_xref="GeneID:855119"
/db_xref="SGD:S000004700"
/translation="MPSFNPVRFLELPIDIRKEVYFHLDGNFCGAHPYPIDILYKSND
VELPGKPSYKRSKRSKKLLRYMYPVFATYLNIFEYSPQLIEKWLEYAFWLRYDCLVLD
CFKVNHLYDGTLIDALEWTYLDNELRLAYFNKASMLEVWYTFKEYKKWVIDSVAFDEL
DLLNVSNIQFNIDNLTPQLVDKCLSILEQKDLFATIGEVQFGQDEEVGEEKDVDVSGA
NSDENSSPSSTIKNKKRSASKRSHSDNGNVGATHNQLTSISVIRTIRSMESMKSLRKI
TVRGEKLYELLINFHGFRDNPGKTISYIVKRRINEIRLSRMNQISRTGLADFTRWDNL
QKLVLSRVAYIDLNSIVFPKNFKSLTMKRVSKIKWWNIEENILKELKVDKRTFKSLYI
KEDDSKFTKFFNLRHTRIKELDKSEINQITYLRCQAIVWLSFRTLNHIKLQNVSEVFN
NIIVPRALFDSKRVEIYRCEKISQVLVI"
gene complement(<457285..>457959)
/gene="SNO1"
/locus_tag="YMR095C"
/db_xref="GeneID:855120"
mRNA complement(<457285..>457959)
/gene="SNO1"
/locus_tag="YMR095C"
/product="putative pyridoxal 5'-phosphate synthase"
/transcript_id="NM_001182595.1"
/db_xref="GeneID:855120"
CDS complement(457285..457959)
/gene="SNO1"
/locus_tag="YMR095C"
/EC_number="3.5.1.2"
/EC_number="4.3.3.6"
/experiment="EXISTENCE:direct assay:GO:0004359 glutaminase
activity [PMID:14764090]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0008615
pyridoxine biosynthetic process [PMID:14764090]"
/experiment="EXISTENCE:mutant phenotype:GO:0036001 'de
novo' pyridoxal 5'-phosphate biosynthetic process
[PMID:30498136]"
/experiment="EXISTENCE:mutant phenotype:GO:0042819 vitamin
B6 biosynthetic process [PMID:12271461]"
/experiment="EXISTENCE:mutant phenotype:GO:0043066
negative regulation of apoptotic process [PMID:18355271]"
/experiment="EXISTENCE:physical interaction:GO:1903600
glutaminase complex [PMID:14764090]"
/note="Protein of unconfirmed function; involved in
pyridoxine metabolism; expression is induced during
stationary phase; forms putative glutamine
amidotransferase complex with Snz1p, with Sno1p serving as
the glutaminase; sno1-delta affects abundance of mRNA from
downstream gene CTF13"
/codon_start=1
/product="putative pyridoxal 5'-phosphate synthase"
/protein_id="NP_013813.1"
/db_xref="GeneID:855120"
/db_xref="SGD:S000004701"
/translation="MHKTHSTMSGKSMKVIGVLALQGAFLEHTNHLKRCLAENDYGIK
IEIKTVKTPEDLAQCDALIIPGGESTSMSLIAQRTGLYPCLYEFVHNPEKVVWGTCAG
LIFLSAQLENESALVKTLGVLKVDVRRNAFGRQAQSFTQKCDFSNFIPGCDNFPATFI
RAPVIERILDPIAVKSLYELPVNGKDVVVAATQNHNILVTSFHPELADSDTRFHDWFI
RQFVSN"
gene <458408..>459301
/gene="SNZ1"
/locus_tag="YMR096W"
/db_xref="GeneID:855121"
mRNA <458408..>459301
/gene="SNZ1"
/locus_tag="YMR096W"
/product="pyridoxine biosynthesis protein SNZ1"
/transcript_id="NM_001182596.1"
/db_xref="GeneID:855121"
CDS 458408..459301
/gene="SNZ1"
/locus_tag="YMR096W"
/EC_number="4.3.3.6"
/experiment="EXISTENCE:direct assay:GO:0036381 pyridoxal
5'-phosphate synthase (glutamine hydrolysing) activity
[PMID:19523954]"
/experiment="EXISTENCE:genetic interaction:GO:0008615
pyridoxine biosynthetic process
[PMID:14764090|PMID:30498136]"
/experiment="EXISTENCE:mutant phenotype:GO:0008615
pyridoxine biosynthetic process [PMID:30498136]"
/experiment="EXISTENCE:mutant phenotype:GO:0042819 vitamin
B6 biosynthetic process [PMID:12271461]"
/experiment="EXISTENCE:physical interaction:GO:1903600
glutaminase complex [PMID:14764090]"
/note="Subunit of a two-component pyridoxal-5'-phosphate
synthase; involved in pyridoxine (vitamin B6) biosynthesis
from glyceraldehyde-3-phosphate, ribose-5-phosphate and
ammonia liberated from glutamine by glutaminase; forms a
complex with Sno1p that functions as an active
glutaminase; member of a stationary phase-induced gene
family where transcriptional induction occurs during the
postdiauxic phase; co-regulated with SNO1; paralog of SNZ2
and SNZ3"
/codon_start=1
/product="pyridoxine biosynthesis protein SNZ1"
/protein_id="NP_013814.1"
/db_xref="GeneID:855121"
/db_xref="SGD:S000004702"
/translation="MTGEDFKIKSGLAQMLKGGVIMDVVTPEQAKIAEKSGACAVMAL
ESIPADMRKSGKVCRMSDPKMIKDIMNSVSIPVMAKVRIGHFVEAQIIEALEVDYIDE
SEVLTPADWTHHIEKDKFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAV
KHIRRITEEIKACQQLKSEDDIAKVAEEMRVPVSLLKDVLEKGKLPVVNFAAGGVATP
ADAALLMQLGCDGVFVGSGIFKSSNPVRLATAVVEATTHFDNPSKLLEVSSDLGELMG
GVSIESISHASNGVRLSEIGW"
gene complement(<459424..>460527)
/gene="MTG1"
/locus_tag="YMR097C"
/db_xref="GeneID:855122"
mRNA complement(<459424..>460527)
/gene="MTG1"
/locus_tag="YMR097C"
/product="putative GTPase MTG1"
/transcript_id="NM_001182597.1"
/db_xref="GeneID:855122"
CDS complement(459424..460527)
/gene="MTG1"
/locus_tag="YMR097C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:12808030]"
/experiment="EXISTENCE:genetic interaction:GO:0032543
mitochondrial translation [PMID:12808030]"
/experiment="EXISTENCE:mutant phenotype:GO:0032543
mitochondrial translation [PMID:12808030]"
/note="Putative GTPase peripheral to the mitochondrial
inner membrane; essential for respiratory competence,
likely functions in assembly of the large ribosomal
subunit, has homologs in plants and animals"
/codon_start=1
/product="putative GTPase MTG1"
/protein_id="NP_013815.1"
/db_xref="GeneID:855122"
/db_xref="SGD:S000004703"
/translation="MHINVRGTRKIISNVSSFTPRYEFPKYSMPLTDFKGHQVKALKT
FEKLLPQMNMIIELRDIRAPLSTRNVVFDRIARKEHDVMKLVVYTRKDLMPGNKPYIG
KLKNWHEELGEKFILLDCRNKTDVRNLLKILEWQNYELETNGGYLPMGYRALITGMPN
VGKSTLINSLRTIFHNQVNMGRKFKKVAKTGAEAGVTRATSEVIRVTSRNTESRNEIY
LIDTPGIGVPGRVSDHNRMLGLALCGSVKNNLVDPIFQADYLLYLMNLQNLNDGRTEL
YPGSTNSPTNDIYDVLRRLQVNKSQNEKSTAIEWTNKWRLHGKGIIFDPEVLLNNDEF
SYKNYVNDQLEKLGDLSYEGLSNKLKGNPNQVF"
gene complement(<460771..>462609)
/gene="ATP25"
/locus_tag="YMR098C"
/db_xref="GeneID:855123"
mRNA complement(<460771..>462609)
/gene="ATP25"
/locus_tag="YMR098C"
/product="Atp25p"
/transcript_id="NM_001182598.1"
/db_xref="GeneID:855123"
CDS complement(460771..462609)
/gene="ATP25"
/locus_tag="YMR098C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:18216280]"
/experiment="EXISTENCE:mutant phenotype:GO:0033615
mitochondrial proton-transporting ATP synthase complex
assembly [PMID:18216280]"
/experiment="EXISTENCE:mutant phenotype:GO:0048255 mRNA
stabilization [PMID:18216280]"
/note="Protein that associates with mitochondrial
ribosome; required for the stability of Oli1p (Atp9p)
mRNA; also required for the Oli1p ring formation; YMR098C
is not an essential gene"
/codon_start=1
/product="Atp25p"
/protein_id="NP_013816.1"
/db_xref="GeneID:855123"
/db_xref="SGD:S000004704"
/translation="MNKFCLLPFHGKRIGVANIPFTILFKKGPYFLHSHITAVYYSTK
GKNDSHEQSRVSKKSTFTPLETPWYLRIVDNEKELMEGKKNNHHTMNKELEIPKTSPN
SLRKIADLLTGKLGLDDFLVFDLRKKSPNSVSAVNKLGDFMVICTARSTKHCHKSFLE
LNKFLKHEFCSSAYVEGNFNERQESRRKRRLARKSNLSKLLGRSSECSAKDLNSEAWY
MIDCRVDGIFVNILTQRRRNELNLEELYAPENEKSKFQNIDSGNVPTISGVNEISSNN
NILLGLRRLAQQRRRYSTINPNGLSNLRYFLQKEDFKGANKIIQSSSGTETHNIRTLE
HVKNTLKDLVGQERKVDVVQWKSLFDEHSTFLTINQSAAYWPLRLEYAILLNKADPQF
YSDRVFLKDYLLLKKSLGQELIREDLIALLEMVLKTQHSSHSYFNLVKQNRVIIRALN
LFKGLQTEDDGSVVYDEVVISLLLNSMVADERVKLRSLYETIDHIFQTFGDKLTSGMI
VSILQNLAKIKDWNKLLQVWEAITPTEGEGQDKRPWNEFINVINQSGDSHVISKIVNN
GHLLWIRRLNVNVTPELCNSIKALLKTAGMENSTLEEFLVRGTNNQ"
repeat_region complement(463128..463461)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007114"
gene 463554..463625
/locus_tag="YNCM0024W"
/db_xref="GeneID:855124"
tRNA 463554..463625
/locus_tag="YNCM0024W"
/product="tRNA-Asp"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:855124"
/db_xref="SGD:S000006543"
gene complement(<463934..>464827)
/locus_tag="YMR099C"
/db_xref="GeneID:855125"
mRNA complement(<463934..>464827)
/locus_tag="YMR099C"
/product="glucose-6-phosphate 1-epimerase"
/transcript_id="NM_001182599.1"
/db_xref="GeneID:855125"
CDS complement(463934..464827)
/locus_tag="YMR099C"
/EC_number="5.1.3.15"
/experiment="EXISTENCE:curator inference:GO:0005975
carbohydrate metabolic process [PMID:16857670]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0047938
glucose-6-phosphate 1-epimerase activity [PMID:16857670]"
/note="Glucose-6-phosphate 1-epimerase (hexose-6-phosphate
mutarotase); likely involved in carbohydrate metabolism;
GFP-fusion protein localizes to both the nucleus and
cytoplasm and is induced in response to the DNA-damaging
agent MMS"
/codon_start=1
/product="glucose-6-phosphate 1-epimerase"
/protein_id="NP_013817.1"
/db_xref="GeneID:855125"
/db_xref="SGD:S000004705"
/translation="MPIKETDKEVVLTHPADETTSVHILKYGATVYSWKLKSEEQLWL
STAAKLDGSKPVRGGIPLVFPVFGKNSTDEHLSKLPQHGLARNSTWEFLGQTKENPPT
VQFGLKPEIANPELTKLWPMDYLLILTVELGSDYLKTAIEVENTSSSKELKFNWLFHT
YFRIEDIEGTMVSNLAGMKLYDQLLKESYVDKHPVVTFNQETDVIYQNVSAERAIQIV
DKGVQIHTLKRYNLPDTVVWNPWIEKSQGMADFEPKTGYQQMICIEPGHVHDFISLAP
GKKWNAYQLLCKEELKYQAIQ"
gene <466300..>468162
/gene="MUB1"
/locus_tag="YMR100W"
/db_xref="GeneID:855126"
mRNA <466300..>468162
/gene="MUB1"
/locus_tag="YMR100W"
/product="Mub1p"
/transcript_id="NM_001182600.1"
/db_xref="GeneID:855126"
CDS 466300..468162
/gene="MUB1"
/locus_tag="YMR100W"
/experiment="EXISTENCE:direct assay:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:18070918]"
/experiment="EXISTENCE:mutant phenotype:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:18070918]"
/experiment="EXISTENCE:physical interaction:GO:1990304
MUB1-RAD6-UBR2 ubiquitin ligase complex [PMID:18070918]"
/note="MYND domain-containing protein; component of the
Mub1p-Ubr2p-Rad6p ubiquitin ligase complex, required for
ubiquitination and degradation of Rpn4p; interacts with
Ubr2p (E3) and indirectly with Rad6p (E2); short-lived
protein degraded in a Ubr2p/Rad6p dependent manner;
proposed to function as both a partner and substrate of
the Ubr2p/Rad6p ubiquitin ligase; similar to the A.
nidulans samB gene"
/codon_start=1
/product="Mub1p"
/protein_id="NP_013818.1"
/db_xref="GeneID:855126"
/db_xref="SGD:S000004706"
/translation="MRDSNHRSLTSNKPIVTITSTVYDRRALDINSSIPLINSLNYLT
YLTSNSSKVRETVANDGALERLVSILRSCHLSLFELLDLDLENFNEHENIKDLWKEKR
LALCAWKWTLTFQCLVLTGTRGTEQIRKKVVMSGVLSVLVTVLDNYLLYHKNYDFIKD
QTMTFDFKGITTETMYKFMRKDENETYQQYIEFITGQDKLKLSTDKNFLNERLVAPSM
TIPTDFSDIWGRFADLASNFEPDQERHDDDIDIDSEVESENFDAHKNFFSQPDINRPT
ISTPREFFLGRIVPKQDDVIWSLQLLAFVSKYTYMKSTLQNVELVESLSFRSMAYKIK
QRISEENDLEEQERDVTVKLSSLYPYLSKNPENNSKVKALDTSKMDPFFKELEELSNR
CQQEEQNEICNNHCPVLNLFERYRVPKPSDDNAYGKDKERINLRKKISDNFERRWSYD
KMKKELTNIVYKNKVLTNVVNIFPLVEKYTVSAENTHDVIYWSSVIMRNSCRKNEILG
VRQCANFSCGKWEDFPRQFAKCRRCKRTKYCSRKCQLKAWGYHRYWCHEVGSSHMRST
NTTTGVNTPNEPSSLNATATTAADVSNSTSTFTPNISTTVPDEISNRDENSIPE"
rep_origin 468179..468469
/note="ARS1316; Autonomously Replicating Sequence"
/db_xref="SGD:S000118372"
gene complement(<468445..>469476)
/gene="SRT1"
/locus_tag="YMR101C"
/db_xref="GeneID:855127"
mRNA complement(<468445..>469476)
/gene="SRT1"
/locus_tag="YMR101C"
/product="ditrans,polycis-polyprenyl diphosphate synthase"
/transcript_id="NM_001182601.1"
/db_xref="GeneID:855127"
CDS complement(468445..469476)
/gene="SRT1"
/locus_tag="YMR101C"
/EC_number="2.5.1.87"
/experiment="EXISTENCE:direct assay:GO:0004659
prenyltransferase activity [PMID:17345630]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:11442630|PMID:24390141]"
/experiment="EXISTENCE:direct assay:GO:0006486 protein
glycosylation [PMID:11442630]"
/experiment="EXISTENCE:direct assay:GO:0019408 dolichol
biosynthetic process [PMID:25066056]"
/experiment="EXISTENCE:direct assay:GO:0045547
dehydrodolichyl diphosphate synthase activity
[PMID:11442630|PMID:25066056]"
/experiment="EXISTENCE:direct assay:GO:1904423
dehydrodolichyl diphosphate synthase complex
[PMID:25066056]"
/experiment="EXISTENCE:mutant phenotype:GO:0006486 protein
glycosylation [PMID:11442630]"
/note="Forms the dehydrodolichyl diphosphate synthase
(DDS) complex with NUS1; involved in synthesis of
long-chain dolichols (19-22 isoprene units; as opposed to
Rer2p which synthesizes shorter-chain dolichols);
localizes to lipid bodies; transcription is induced during
stationary phase"
/codon_start=1
/product="ditrans,polycis-polyprenyl diphosphate synthase"
/protein_id="NP_013819.1"
/db_xref="GeneID:855127"
/db_xref="SGD:S000004707"
/translation="MKMPSIIQIQFVALKRLLVETKEQMCFAVKSIFQRVFAWVMSLS
LFSWFYVNLQNILIKALRVGPVPEHVSFIMDGNRRYAKSRRLPVKKGHEAGGLTLLTL
LYICKRLGVKCVSAYAFSIENFNRPKEEVDTLMNLFTVKLDEFAKRAKDYKDPLYGSK
IRIVGDQSLLSPEMRKKIKKVEEITQDGDDFTLFICFPYTSRNDMLHTIRDSVEDHLE
NKSPRINIRKFTNKMYMGFHSNKCELLIRTSGHRRLSDYMLWQVHENATIEFSDTLWP
NFSFFAMYLMILKWSFFSTIQKYNEKNHSLFEKIHESVPSIFKKKKTAMSLYNFPNPP
ISVSVTGDE"
gene complement(<469848..>472352)
/gene="LAF1"
/locus_tag="YMR102C"
/db_xref="GeneID:855128"
mRNA complement(<469848..>472352)
/gene="LAF1"
/locus_tag="YMR102C"
/product="Laf1p"
/transcript_id="NM_001182602.1"
/db_xref="GeneID:855128"
CDS complement(469848..472352)
/gene="LAF1"
/locus_tag="YMR102C"
/experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol
transport [PMID:33255682]"
/note="Sterol-binding beta-propeller protein; physically
associates with sterol-binding StARkin domain-containing
proteins Ysp2/Lam2/Ltc4 and Lam4/Ltc3; essential for
retrograde transport of ergosterol from the plasma
membrane to the endoplasmic reticulum at ER-PM contact
sites; transcription is activated by paralogous
transcription factors Yrm1p and Yrr1p along with genes
involved in multidrug resistance; non-essential gene; has
a paralog, DGR2, that arose from the whole genome
duplication"
/codon_start=1
/product="Laf1p"
/protein_id="NP_013820.1"
/db_xref="GeneID:855128"
/db_xref="SGD:S000004708"
/translation="MTNMAEDKTSISKVHSEFSNSSNTTGSEEESRSHQESFDGESSS
GESKSKSKLNLEYSADIEPLKFRMTKTNNTNDKLKYSNNGNATDSFMRLKEHLQRGNT
LNSNLRVNEFYPFNSIDTEQFENYLREPKYIKMLKRRKNLKQFRRLFLAQELMAYEGE
TVTSTSKSSEPTSKAIWSTKFSRDGKFMATGSKDGKIRIWKVIGSPVERAELDSSAES
NKEARAKSMRIKQQVSSLNNPKEKQFLDSATEKYEEKEKLLNLYAPVFHPTPLRLYKE
HVQDVLDINWSKNNFILSASMDKTVKLWHPDRKNSLKTFIHPDFVTCVEFHPTDDRFF
ISGCLDHKCRLWSILDDEVSFEYDCQDLITSVTLSPEEGKYTIIGTFNGYVHILMTRG
LTPVSSFHVADRQTQEQNAHVMVTETDSKIRHGPRVTGLQAFRSQLDNSFRLVVTSND
SRIRIFDLEQRKLLEVLKGFHSGSSQHKAQLSIWHGQPIVVNSSDDHWVYGWRLKSSD
RENDQDEPKRKPKGLARSGSLRSIFSKSMSRSSSQNNEEKPHHHLKLTNLLPLPHHSN
DHYIKNTDYISFHAHNAPVTCVSIAPPETSKTLSLSNDVICELSLEFFQTSDSFDVLS
RSNDDGIMSDVESSLGYNSKPGSISNASATSAIPDVVDAIGTILISTDNVGTIRVFRA
DMPSVIRKRVLLKLEEYNREVRRRFNSSDSLHSLSRSFNSRAKSNLAGQPAAAYTNTG
KGYATGRGYSNICPKSSTSLKTLGSNAQPRTPRESMSSIFSNAHGPTTPTSAMNLPIR
CNVCNGSRFEAFSGANDQQDRNYYCVDCGTVVNNFR"
gene complement(<472902..>473264)
/locus_tag="YMR103C"
/db_xref="GeneID:855129"
mRNA complement(<472902..>473264)
/locus_tag="YMR103C"
/product="uncharacterized protein"
/transcript_id="NM_001348866.1"
/db_xref="GeneID:855129"
CDS complement(472902..473264)
/locus_tag="YMR103C"
/note="hypothetical protein; conserved among S. cerevisiae
strains; YMR103C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335806.1"
/db_xref="GeneID:855129"
/db_xref="SGD:S000004709"
/translation="MVRRGCALLLATLTRLMLLIHFFYSIIRILPSTELRSKTDLLSA
EGRTLIPADVKAKPAGRKSRLPEFAKRQRTLALPERKDSLFCLLPLFLHSLGREQLIS
SADDPGFPCAGSAMGSLT"
gene complement(<473420..>475453)
/gene="YPK2"
/locus_tag="YMR104C"
/gene_synonym="YKR2"
/db_xref="GeneID:855130"
mRNA complement(<473420..>475453)
/gene="YPK2"
/locus_tag="YMR104C"
/gene_synonym="YKR2"
/product="putative protein kinase YPK2"
/transcript_id="NM_001182604.1"
/db_xref="GeneID:855130"
CDS complement(473420..475453)
/gene="YPK2"
/locus_tag="YMR104C"
/gene_synonym="YKR2"
/EC_number="2.7.11.1"
/experiment="EXISTENCE:direct assay:GO:0004674 protein
serine/threonine kinase activity [PMID:16478726]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:12221112]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:genetic interaction:GO:0060237
regulation of fungal-type cell wall organization
[PMID:12221112]"
/experiment="EXISTENCE:genetic interaction:GO:0070941
eisosome assembly [PMID:18296441]"
/experiment="EXISTENCE:mutant phenotype:GO:0004674 protein
serine/threonine kinase activity [PMID:16478726]"
/note="AGC-type S/T protein kinase; participates in the
cell wall integrity signaling pathway; involved with Ypk1p
in the TORC-dependent phosphorylation of ribosomal
proteins Rps6a/b (S6), and in the direct phosphorylation
of the Myo5p motor domain TEDS site; phosphorylated and
activated by Pkh1/2p in the presence of phytosphingosine;
direct phosphorylation by Tor2p regulates actin
polarization; genetically redundant with YPK1; human
homolog SGK2 can complement the inviability of a ypk1 ypk2
mutant"
/codon_start=1
/product="putative protein kinase YPK2"
/protein_id="NP_013822.1"
/db_xref="GeneID:855130"
/db_xref="SGD:S000004710"
/translation="MHSWRISKFKLGRSKEDDGSSEDENEKSWGNGLFHFHHGEKHHD
GSPKNHNHEHEHHIRKINTNETLPSSLSSPKLRNDASFKNPSGIGNDNSKASERKASQ
SSTETQGPSSESGLMTVKVYSGKDFTLPFPITSNSTILQKLLSSGILTSSSNDASEVA
AIMRQLPRYKRVDQDSAGEGLIDRAFATKFIPSSILLPGSTNSSPLLYFTIEFDNSIT
TISPDMGTMEQPVFNKISTFDVTRKLRFLKIDVFARIPSLLLPSKNWQQEIGEQDEVL
KEILKKINTNQDIHLDSFHLPLNLKIDSAAQIRLYNHHWISLERGYGKLNITVDYKPS
KNKPLSIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAE
RTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAE
LLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEY
LAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFD
PAAKDLLIGLLSRDPSRRLGVNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEI
DTANFDQEFTKEKPIDSVVDEYLSASIQKQFGGWTYIGDEQLGDSPSQGRSIS"
gene complement(<475897..>477606)
/gene="PGM2"
/locus_tag="YMR105C"
/gene_synonym="GAL5"
/db_xref="GeneID:855131"
mRNA complement(<475897..>477606)
/gene="PGM2"
/locus_tag="YMR105C"
/gene_synonym="GAL5"
/product="phosphoglucomutase PGM2"
/transcript_id="NM_001182605.1"
/db_xref="GeneID:855131"
CDS complement(475897..477606)
/gene="PGM2"
/locus_tag="YMR105C"
/gene_synonym="GAL5"
/EC_number="5.4.2.2"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:8385141]"
/experiment="EXISTENCE:genetic interaction:GO:0004614
phosphoglucomutase activity [PMID:8119301]"
/experiment="EXISTENCE:genetic interaction:GO:0005978
glycogen biosynthetic process [PMID:9252577]"
/experiment="EXISTENCE:genetic interaction:GO:0005992
trehalose biosynthetic process [PMID:9252577]"
/experiment="EXISTENCE:genetic interaction:GO:0006011
UDP-glucose metabolic process [PMID:9252577]"
/experiment="EXISTENCE:genetic interaction:GO:0006874
intracellular calcium ion homeostasis [PMID:15252028]"
/experiment="EXISTENCE:genetic interaction:GO:0019255
glucose 1-phosphate metabolic process [PMID:8119301]"
/experiment="EXISTENCE:genetic interaction:GO:0019388
galactose catabolic process [PMID:8119301]"
/experiment="EXISTENCE:genetic interaction:GO:0051156
glucose 6-phosphate metabolic process [PMID:8119301]"
/experiment="EXISTENCE:mutant phenotype:GO:0004614
phosphoglucomutase activity
[PMID:2138705|PMID:8119301|PMID:13887540]"
/experiment="EXISTENCE:mutant phenotype:GO:0006874
intracellular calcium ion homeostasis
[PMID:10681519|PMID:15252028]"
/experiment="EXISTENCE:mutant phenotype:GO:0019255 glucose
1-phosphate metabolic process
[PMID:10681519|PMID:8119301]"
/experiment="EXISTENCE:mutant phenotype:GO:0019388
galactose catabolic process
[PMID:8119301|PMID:13887540|PMID:14264884]"
/experiment="EXISTENCE:mutant phenotype:GO:0030003
intracellular monoatomic cation homeostasis
[PMID:15164360]"
/note="Phosphoglucomutase; catalyzes the conversion from
glucose-1-phosphate to glucose-6-phosphate, which is a key
step in hexose metabolism; functions as the acceptor for a
Glc-phosphotransferase; protein abundance increases in
response to DNA replication stress; PGM2 has a paralog,
PGM1, that arose from the whole genome duplication"
/codon_start=1
/product="phosphoglucomutase PGM2"
/protein_id="NP_013823.1"
/db_xref="GeneID:855131"
/db_xref="SGD:S000004711"
/translation="MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSI
MEAIPEGSKGATLVVGGDGRYYNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHI
MRTYEEKCTGGIILTASHNPGGPENDMGIKYNLSNGGPAPESVTNAIWEISKKLTSYK
IIKDFPELDLGTIGKNKKYGPLLVDIIDITKDYVNFLKEIFDFDLIKKFIDNQRSTKN
WKLLFDSMNGVTGPYGKAIFVDEFGLPADEVLQNWHPSPDFGGMHPDPNLTYASSLVK
RVDREKIEFGAASDGDGDRNMIYGYGPSFVSPGDSVAIIAEYAAEIPYFAKQGIYGLA
RSFPTSGAIDRVAKAHGLNCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNHVREKD
GVWAIMAWLNILAIYNKHHPENEASIKTIQNEFWAKYGRTFFTRYDFEKVETEKANKI
VDQLRAYVTKSGVVNSAFPADESLKVTDCGDFSYTDLDGSVSDHQGLYVKLSNGARFV
LRLSGTGSSGATIRLYIEKYCDDKSQYQKTAEEYLKPIINSVIKFLNFKQVLGTEEPT
VRT"
rep_origin 477606..478301
/note="ARS1317; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130188"
gene <478064..>478258
/locus_tag="YMR105W-A"
/db_xref="GeneID:1466500"
mRNA <478064..>478258
/locus_tag="YMR105W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184614.1"
/db_xref="GeneID:1466500"
CDS 478064..478258
/locus_tag="YMR105W-A"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878142.1"
/db_xref="GeneID:1466500"
/db_xref="SGD:S000028692"
/translation="MILVHTGNVLYPRFIVVAFTFEQRQGGRCKGGKATCMASVQSYK
VTMQISSMTIIYPLFIFFSL"
gene complement(<478301..>480190)
/gene="YKU80"
/locus_tag="YMR106C"
/gene_synonym="HDF2"
/db_xref="GeneID:855132"
mRNA complement(<478301..>480190)
/gene="YKU80"
/locus_tag="YMR106C"
/gene_synonym="HDF2"
/product="ATP-dependent DNA helicase YKU80"
/transcript_id="NM_001182606.1"
/db_xref="GeneID:855132"
CDS complement(478301..480190)
/gene="YKU80"
/locus_tag="YMR106C"
/gene_synonym="HDF2"
/EC_number="3.6.4.12"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:16166630]"
/experiment="EXISTENCE:direct assay:GO:0006325 chromatin
organization [PMID:11553718]"
/experiment="EXISTENCE:direct assay:GO:0007535 donor
selection [PMID:16166630]"
/experiment="EXISTENCE:direct assay:GO:0042162 telomeric
DNA binding [PMID:17656141]"
/experiment="EXISTENCE:direct assay:GO:0043564 Ku70:Ku80
complex [PMID:8754818]"
/experiment="EXISTENCE:direct assay:GO:0070034 telomerase
RNA binding [PMID:12975323]"
/experiment="EXISTENCE:genetic interaction:GO:0007535
donor selection [PMID:16809780]"
/experiment="EXISTENCE:genetic interaction:GO:0034502
protein localization to chromosome [PMID:18716325]"
/experiment="EXISTENCE:mutant phenotype:GO:0000723
telomere maintenance [PMID:9501103]"
/experiment="EXISTENCE:mutant phenotype:GO:0000724
double-strand break repair via homologous recombination
[PMID:11016833]"
/experiment="EXISTENCE:mutant phenotype:GO:0000781
chromosome, telomeric region [PMID:27122604]"
/experiment="EXISTENCE:mutant phenotype:GO:0006303
double-strand break repair via nonhomologous end joining
[PMID:9501103]"
/experiment="EXISTENCE:mutant phenotype:GO:0007535 donor
selection [PMID:16166630|PMID:16809780]"
/experiment="EXISTENCE:mutant phenotype:GO:0031509
subtelomeric heterochromatin formation [PMID:9501103]"
/experiment="EXISTENCE:mutant phenotype:GO:0097695
establishment of protein-containing complex localization
to telomere [PMID:15531893]"
/note="Subunit of telomeric Ku complex (Yku70p-Yku80p);
involved in telomere length maintenance, structure and
telomere position effect; required for localization of
telomerase ribonucleoprotein via interaction with TLC1
guide RNA; relocates to sites of double-strand cleavage to
promote nonhomologous end joining during DSB repair;
colocalizes with quiescent cell telomere hyperclusters"
/codon_start=1
/product="ATP-dependent DNA helicase YKU80"
/protein_id="NP_013824.1"
/db_xref="GeneID:855132"
/db_xref="SGD:S000004712"
/translation="MSSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTD
WISCYLANCPVSENSQEIPNVFQIQSFLAPVTTTATIGFIKRLKQYCDQHSHDSSNEG
LQSMIQCLLVVSLDIKQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRIIL
IDCGKDTQEERKKSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGELRL
GADILSTQTSNPSGSMQDENCLCIKVEAFPATKAVSGLNRKTAVEVEDSQKKERYVGV
KSIIEYEIHNEGNKKNVSEDDQSGSSYIPVTISKDSVTKAYRYGADYVVLPSVLVDQT
VYESFPGLDLRGFLNREALPRYFLTSESSFITADTRLGCQSDLMAFSALVDVMLENRK
IAVARYVSKKDSEVNMCALCPVLIEHSNINSEKKFVKSLTLCRLPFAEDERVTDFPKL
LDRTTTSGVPLKKETDGHQIDELMEQFVDSMDTDELPEIPLGNYYQPIGEVTTDTTLP
LPSLNKDQEENKKDPLRIPTVFVYRQQQVLLEWIHQLMINDSREFEIPELPDSLKNKI
SPYTHKKFDSTKLVEVLGIKKVDKLKLDSELKTELEREKIPDLETLLKRGEQHSRGSP
NNSNN"
gene complement(480621..480693)
/locus_tag="YNCM0025C"
/db_xref="GeneID:855133"
tRNA complement(480621..480693)
/locus_tag="YNCM0025C"
/product="tRNA-Lys"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:8915539]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:8915539]"
/experiment="EXISTENCE:mutant phenotype:GO:0030533 triplet
codon-amino acid adaptor activity [PMID:17560369]"
/experiment="EXISTENCE:mutant phenotype:GO:0032543
mitochondrial translation [PMID:17560369]"
/note="Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE
analysis; a small portion is imported into mitochondria
via interaction with mt lysyl-tRNA synthetase Msk1p and is
necessary to decode AAG codons at high temperature, when
base modification of mt-encoded tRNA-Lys is reduced"
/db_xref="GeneID:855133"
/db_xref="SGD:S000006627"
repeat_region complement(481214..481547)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007115"
repeat_region 481571..481808
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007122"
gene <483014..>483361
/gene="SPG4"
/locus_tag="YMR107W"
/db_xref="GeneID:855134"
mRNA <483014..>483361
/gene="SPG4"
/locus_tag="YMR107W"
/product="Spg4p"
/transcript_id="NM_001182607.1"
/db_xref="GeneID:855134"
CDS 483014..483361
/gene="SPG4"
/locus_tag="YMR107W"
/note="Protein required for high temperature survival
during stationary phase; not required for growth on
nonfermentable carbon sources"
/codon_start=1
/product="Spg4p"
/protein_id="NP_013825.1"
/db_xref="GeneID:855134"
/db_xref="SGD:S000004713"
/translation="MGSFWDAFAVYDKKKHADPSVYGGNHNNTGDSKTQVMFSKEYRQ
PRTHQQENLQSMRRSSIGSQDSSDVEDVKEGRLPAEVEIPKNVDISNMSQGEFLRLYE
SLRRGEPDNKVNR"
gene <484084..>486147
/gene="ILV2"
/locus_tag="YMR108W"
/gene_synonym="SMR1; THI1"
/db_xref="GeneID:855135"
mRNA <484084..>486147
/gene="ILV2"
/locus_tag="YMR108W"
/gene_synonym="SMR1; THI1"
/product="acetolactate synthase catalytic subunit"
/transcript_id="NM_001182608.1"
/db_xref="GeneID:855135"
CDS 484084..486147
/gene="ILV2"
/locus_tag="YMR108W"
/gene_synonym="SMR1; THI1"
/EC_number="2.2.1.6"
/experiment="EXISTENCE:direct assay:GO:0003984
acetolactate synthase activity [PMID:10213630]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005948
acetolactate synthase complex [PMID:10213630]"
/experiment="EXISTENCE:direct assay:GO:0009082
branched-chain amino acid biosynthetic process
[PMID:2406721]"
/experiment="EXISTENCE:direct assay:GO:0050660 flavin
adenine dinucleotide binding [PMID:15709745]"
/experiment="EXISTENCE:mutant phenotype:GO:0009082
branched-chain amino acid biosynthetic process
[PMID:2406721]"
/note="Acetolactate synthase; catalyses the first common
step in isoleucine and valine biosynthesis and is the
target of several classes of inhibitors, localizes to the
mitochondria; expression of the gene is under general
amino acid control"
/codon_start=1
/product="acetolactate synthase catalytic subunit"
/protein_id="NP_013826.1"
/db_xref="GeneID:855135"
/db_xref="SGD:S000004714"
/translation="MIRQSTLKNFAIKRCFQHIAYRNTPAMRSVALAQRFYSSSSRYY
SASPLPASKRPEPAPSFNVDPLEQPAEPSKLAKKLRAEPDMDTSFVGLTGGQIFNEMM
SRQNVDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVL
VTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVGISRSCTKWNV
MVKSVEELPLRINEAFEIATSGRPGPVLVDLPKDVTAAILRNPIPTKTTLPSNALNQL
TSRAQDEFVMQSINKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVTTT
LQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADLIIAVGARFDDRVTGNISKFAPEA
RRAAAEGRGGIIHFEVSPKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQ
INKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRHVIVTTGVGQHQMWAAQHW
TWRNPHTFITSGGLGTMGYGLPAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQA
GTPVKILILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKLAEAMGLKGLRVKKQEE
LDAKLKEFVSTKGPVLLEVEVDKKVPVLPMVAGGSGLDEFINFDPEVERQQTELRHKR
TGGKH"
gene <486587..>490246
/gene="MYO5"
/locus_tag="YMR109W"
/db_xref="GeneID:855136"
mRNA <486587..>490246
/gene="MYO5"
/locus_tag="YMR109W"
/product="myosin 5"
/transcript_id="NM_001182609.1"
/db_xref="GeneID:855136"
CDS 486587..490246
/gene="MYO5"
/locus_tag="YMR109W"
/experiment="EXISTENCE:direct assay:GO:0000146
microfilament motor activity [PMID:16824951]"
/experiment="EXISTENCE:direct assay:GO:0005933 cellular
bud [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0030479 actin
cortical patch [PMID:16824951|PMID:20647997]"
/experiment="EXISTENCE:direct assay:GO:0043332 mating
projection tip [PMID:19053807]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:2000601 positive
regulation of Arp2/3 complex-mediated actin nucleation
[PMID:16824951]"
/experiment="EXISTENCE:genetic interaction:GO:0009651
response to salt stress [PMID:12391157]"
/experiment="EXISTENCE:genetic interaction:GO:0051666
actin cortical patch localization [PMID:18177206]"
/experiment="EXISTENCE:genetic interaction:GO:0061709
reticulophagy [PMID:35101986]"
/experiment="EXISTENCE:mutant phenotype:GO:0006897
endocytosis [PMID:16824951]"
/experiment="EXISTENCE:mutant phenotype:GO:0006898
receptor-mediated endocytosis [PMID:8614799]"
/experiment="EXISTENCE:mutant phenotype:GO:0051666 actin
cortical patch localization [PMID:18177206]"
/experiment="EXISTENCE:mutant phenotype:GO:0061709
reticulophagy [PMID:35101986]"
/experiment="EXISTENCE:mutant phenotype:GO:2000601
positive regulation of Arp2/3 complex-mediated actin
nucleation [PMID:16824951]"
/experiment="EXISTENCE:physical interaction:GO:0009651
response to salt stress [PMID:12391157]"
/note="One of two type I myosin motors; involved in
clathrin-mediated endocytosis; activation by TEDS site
phosphorylation increases actin gliding, motor activity
and ligand-induced endocytosis; contains proline-rich tail
homology 2 (TH2) and SH3 domains; MYO5 deletion has little
effect on growth, but myo3 myo5 double deletion causes
severe defects in growth and actin cytoskeleton
organization; MYO5 has a paralog, MYO3, that arose from
the whole genome duplication"
/codon_start=1
/product="myosin 5"
/protein_id="NP_013827.1"
/db_xref="GeneID:855136"
/db_xref="SGD:S000004715"
/translation="MAILKRGARKKVHQEPAKRSANIKKATFDSSKKKEVGVSDLTLL
SKISDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLGIYTDAVMNEYKGKNRLEVP
PHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASSTHTESIGKI
KDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLEKQRVV
SQIKNERNFHIFYQFTKGASDAYRQTFGVQKPEQYVYTAAAGCISAETIDDLQDYQET
LKAMRVIGLGQEEQDQIFRMLAAILWIGNVSFIENEEGNAQVRDTSVTDFVAYLLQID
SQLLIKSLVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVN
KSLQAFPGAEKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYE
REKIQWTPIKYFDNKVVCDLIEARRPPGIFAAMNDSVATAHADSNAADQAFAQRLNLF
TTNPHFDLRSNKFVIKHYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFP
DTVDRESKRRPPTAGDKIIKSANDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQVLH
QIKYLGLQENVRIRRAGFAYRQVFEKFVERFYLLSPHCSYAGDYTWQGDTLDAVKYIL
QDSSIPQQEYQLGVTSVFIKTPETLFALEHMRDRYWHNMAARIQRAWRRFLQRRIDAA
TKIQRTIRERKEGNKYEKLRDYGTKVLGGRKERRSMSLLGYRAFMGDYLSCNESKSKG
AYIKRQVSIKEKVIFSIHGEALHTKFGRSAQRLKKTFLLTPTTLYIVGQTLVQNAMTY
TQDYKIDVRNIQAVSLTNLQDDWVAIKLASSGQPDPLINTYFKTELITHLKRLNDKIQ
IKIGSAIEYQKKPGKLHSVKCQINESAPKYGDIYKSSTISVRRGNPPNSQVHKKPRKK
SSISSGYHASSSQATRRPVSIAAAQHVPTAPASRHSKKPAPPPPGMQNKAATRRSVPN
PASTLTASQSNARPSPPTAATRATPAATPAAAAMGSGRQANIPPPPPPPPPSSKPKEP
MFEAAYDFPGSGSPSELPLKKGDVIYITREEPSGWSLGKLLDGSKEGWVPTAYMKPHS
GNNNIPTPPQNRDVPKPVLNSVQHDNTSANVIPAAAQASLGDGLANALAARANKMRLE
SDDEEANEDEEEDDW"
gene complement(<490394..>491992)
/gene="HFD1"
/locus_tag="YMR110C"
/db_xref="GeneID:855137"
mRNA complement(<490394..>491992)
/gene="HFD1"
/locus_tag="YMR110C"
/product="hexadecenal dehydrogenase"
/transcript_id="NM_001182610.1"
/db_xref="GeneID:855137"
CDS complement(490394..491992)
/gene="HFD1"
/locus_tag="YMR110C"
/EC_number="1.2.1.3"
/EC_number="1.2.1.64"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane
[PMID:16407407|PMID:16689936]"
/experiment="EXISTENCE:direct assay:GO:0005768 endosome
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:14562095|PMID:24868093]"
/experiment="EXISTENCE:mutant phenotype:GO:0006081
cellular aldehyde metabolic process [PMID:22633490]"
/experiment="EXISTENCE:mutant phenotype:GO:0006665
sphingolipid metabolic process [PMID:22633490]"
/experiment="EXISTENCE:mutant phenotype:GO:0006744
ubiquinone biosynthetic process [PMID:27669165]"
/experiment="EXISTENCE:mutant phenotype:GO:0018484
4-hydroxybenzaldehyde dehydrogenase activity
[PMID:27693056|PMID:33862086|PMID:27669165]"
/experiment="EXISTENCE:mutant phenotype:GO:0032180
ubiquinone biosynthetic process from tyrosine
[PMID:27693056|PMID:33862086]"
/experiment="EXISTENCE:mutant phenotype:GO:0046185
aldehyde catabolic process [PMID:25545362]"
/experiment="EXISTENCE:mutant phenotype:GO:0047770
carboxylate reductase activity [PMID:22633490]"
/note="Dehydrogenase involved in ubiquinone and
sphingolipid metabolism; converts 4-hydroxybenzaldehyde
into 4-hydroxybenzoate for ubiquinone anabolism,
hexadecenal to hexadecenoic acid in sphingosine
1-phosphate catabolism; human homolog ALDH3A2, mutated in
Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant;
human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory
growth phenotype of hfd1 null; data suggest that dual
functions of Hfd1p have diverged in human ALDH3A1,
ALDH3A2"
/codon_start=1
/product="hexadecenal dehydrogenase"
/protein_id="NP_013828.1"
/db_xref="GeneID:855137"
/db_xref="SGD:S000004716"
/translation="MSNDGSKILNYTPVSKIDEIVEISRNFFFEKQLKLSHENNPRKK
DLEFRQLQLKKLYYAVKDHEEELIDAMYKDFHRNKIESVLNETTKLMNDILHLIEILP
KLIKPRRVSDSSPPFMFGKTIVEKISRGSVLIIAPFNFPLLLAFAPLAAALAAGNTIV
LKPSELTPHTAVVMENLLTTAGFPDGLIQVVQGAIDETTRLLDCGKFDLIFYTGSPRV
GSIVAEKAAKSLTPCVLELGGKSPTFITENFKASNIKIALKRIFFGAFGNSGQICVSP
DYLLVHKSIYPKVIKECESVLNEFYPSFDEQTDFTRMIHEPAYKKAVASINSTNGSKI
VPSKISINSDTEDLCLVPPTIVYNIGWDDPLMKQENFAPVLPIIEYEDLDETINKIIE
EHDTPLVQYIFSDSQTEINRILTRLRSGDCVVGDTVIHVGITDAPFGGIGTSGYGNYG
GYYGFNTFSHERTIFKQPYWNDFTLFMRYPPNSAQKEKLVRFAMERKPWFDRNGNNKW
GLRQYFSLSAAVILISTIYAHCSS"
gene complement(<492404..>493792)
/gene="EUC1"
/locus_tag="YMR111C"
/db_xref="GeneID:855138"
mRNA complement(<492404..>493792)
/gene="EUC1"
/locus_tag="YMR111C"
/product="Euc1p"
/transcript_id="NM_001182611.1"
/db_xref="GeneID:855138"
CDS complement(492404..493792)
/gene="EUC1"
/locus_tag="YMR111C"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:31015336]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding [PMID:31015336]"
/experiment="EXISTENCE:mutant phenotype:GO:0031503
protein-containing complex localization [PMID:31015336]"
/note="Sequence-specific DNA binding protein; binds to a
sequence motif associated with distinct genomic hotspots
of non-H2B protein ubiquitylation (ub-hotspots); interacts
with Slx5p to recruit the Slx5-Slx8 SUMO-targeted Ub
ligase (STUbL) complex to ub-hotspots; deletion prevents
ub-hotspot formation and exacerbates heat sensitivity of
cells deficient in Rpd3L histone deacetylase complex
members; forms nuclear foci upon DNA replication stress"
/codon_start=1
/product="Euc1p"
/protein_id="NP_013829.1"
/db_xref="GeneID:855138"
/db_xref="SGD:S000004717"
/translation="MPAREYNYVEGFGGYGSLDDDDSDRDSERRNHDLGQRTITTSPT
GVSRHAALNRYMIPGRINPLFRPTDAAQPPIVSTSTSASATEPTNRIGPGRIKETPET
NFNAFLIAQLTRMEEQNANLKEEISLMKKEQELFFLENQKKLEKGFKDINKYVEDVSA
MKEVFKEVVGIMTGERIRFIDHTGENVTPQEAARVGNPSTSTQAHQSQSRSTNWQEYS
MHASILAGDPRIKPEPGLSDFENGEYDGNESDENATTRNLPLNNPDSVSNADDSNNQL
DGTGNENDIRNRRGCVGTSYKLNRAIQNVTDAAREYFEGLPGQPSVLSLERRYGSTWR
RSAKERTLFTKRMTIIKRIIDIKDDPSKYGLSLPENKISRNQAIKVVENIRLGNNTFK
GHHCRLSMSQLYEYFSKKMDKLEDYSLTLKRRGKPRRIFLLEEREARLSLQQPHSIPN
SSTGTPEHDQDT"
gene complement(<494100..>494495)
/gene="MED11"
/locus_tag="YMR112C"
/db_xref="GeneID:855139"
mRNA complement(<494100..>494495)
/gene="MED11"
/locus_tag="YMR112C"
/product="Med11p"
/transcript_id="NM_001182612.1"
/db_xref="GeneID:855139"
CDS complement(494100..494495)
/gene="MED11"
/locus_tag="YMR112C"
/experiment="EXISTENCE:direct assay:GO:0001097 TFIIH-class
transcription factor complex binding [PMID:18691966]"
/experiment="EXISTENCE:direct assay:GO:0070847 core
mediator complex [PMID:9891034]"
/experiment="EXISTENCE:mutant phenotype:GO:0000122
negative regulation of transcription by RNA polymerase II
[PMID:9891034]"
/experiment="EXISTENCE:mutant phenotype:GO:0003713
transcription coactivator activity [PMID:18691966]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:9891034]"
/experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
polymerase II preinitiation complex assembly
[PMID:18691966]"
/note="Subunit of the RNA polymerase II mediator complex;
associates with core polymerase subunits to form the RNA
polymerase II holoenzyme; essential protein"
/codon_start=1
/product="Med11p"
/protein_id="NP_013830.1"
/db_xref="GeneID:855139"
/db_xref="SGD:S000004718"
/translation="MQVLNTKSETKQENETMQPPYIQERLKSLNDIETQLCSMLQEAS
QVTFIFGELKRGNESVKPQFENHVKQFYERLDKSTTQLRKEIQLLDENVGTRLLPINV
NKKALGQDTEKMEEQLDLLSAILDPSKSK"
gene <494999..>496282
/gene="FOL3"
/locus_tag="YMR113W"
/db_xref="GeneID:855140"
mRNA <494999..>496282
/gene="FOL3"
/locus_tag="YMR113W"
/product="dihydrofolate synthase"
/transcript_id="NM_001182613.1"
/db_xref="GeneID:855140"
CDS 494999..496282
/gene="FOL3"
/locus_tag="YMR113W"
/EC_number="6.3.2.12"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0008841
dihydrofolate synthase activity [PMID:11731153]"
/experiment="EXISTENCE:mutant phenotype:GO:0009396 folic
acid-containing compound biosynthetic process
[PMID:11731153]"
/note="Dihydrofolate synthetase, involved in folic acid
biosynthesis; catalyzes conversion of dihydropteroate to
dihydrofolate in folate coenzyme biosynthesis; FOL3 has a
paralog, RMA1, that arose from the whole genome
duplication"
/codon_start=1
/product="dihydrofolate synthase"
/protein_id="NP_013831.1"
/db_xref="GeneID:855140"
/db_xref="SGD:S000004719"
/translation="MAIELGLSRITKLLEHLGNPQNSLRVLHIAGTNGKGSVCTYLSS
VLQQKSYQIGKFTTPHLVHVTDSITINNKPIPLERYQNIRLQLEALNKSHSLKCTEFE
LLTCTAFKYFYDVQCQWCVIEVGLGGRLDATNVIPGANKACCGITKISLDHESFLGNT
LSEISKEKAGIITEGVPFTVIDGTNEASVINVVKERCKALGSELSVTDSQLNGNMIDT
NSWGCFDLAKLPLNGEYQIFNLRVAMGMLDYLQMNELIDITKNEVSTRLAKVDWPGRL
YRMDYRFDKVSNRTVPILMDGAHNGSAAVELVKYLRKEYGNQPLTFVMAVTHGKNLEP
LLQPLLRPIDQVILTRFNNVEGMPWIHATDPEEIKDFILTQGYTKEIVIENDLHQVLP
SLAHVSDEQRRPIVVCGSLYLCGELLRIHNSHLRN"
gene complement(<496343..>497449)
/locus_tag="YMR114C"
/db_xref="GeneID:855141"
mRNA complement(<496343..>497449)
/locus_tag="YMR114C"
/product="putative peptide hydrolase"
/transcript_id="NM_001182614.1"
/db_xref="GeneID:855141"
CDS complement(496343..497449)
/locus_tag="YMR114C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:24390141]"
/note="hypothetical protein; may interact with ribosomes,
based on co-purification experiments; green fluorescent
protein (GFP)-fusion protein localizes to the nucleus and
cytoplasm; YMR114C is not an essential gene"
/codon_start=1
/product="putative peptide hydrolase"
/protein_id="NP_013832.1"
/db_xref="GeneID:855141"
/db_xref="SGD:S000004720"
/translation="MCGRFALAYDSGDLPQLLRDWNLPVNTPKDASSNSQHPHDEEDT
KDQPTVSKDIFKASYNISPTNYSAVYRPDTKAIQFMRWGLVPFWTKDVSQFKTYRTFN
ARLENLQESKMWMRPCEKKRCAVLMSGYFEWKTVGKKKTPYFISRRDGRLMFVAGMYD
YVEKDDLYTFTIITAQGPRELEWLHERMPCVLEPGTESWDAWMDVDKTTWSTEELVKL
LKPDYDESKLQFYQVTDDVGKTTNTGERLIKPLLKEDSDMFSVKREKEEALLENDNEQ
GIDNRGVKGDKSLKGEDVFNQKKSLKRNSYDGLKKNEEQEETTLPEEGSIGDRVKREE
ANLSPKREGNREKRNIVNMLGNQKDSRGKKKIKK"
gene <497704..>499209
/gene="MGR3"
/locus_tag="YMR115W"
/gene_synonym="FMP24"
/db_xref="GeneID:855142"
mRNA <497704..>499209
/gene="MGR3"
/locus_tag="YMR115W"
/gene_synonym="FMP24"
/product="Mgr3p"
/transcript_id="NM_001182615.1"
/db_xref="GeneID:855142"
CDS 497704..499209
/gene="MGR3"
/locus_tag="YMR115W"
/gene_synonym="FMP24"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:18843051]"
/experiment="EXISTENCE:direct assay:GO:0031942 i-AAA
complex [PMID:18843051]"
/experiment="EXISTENCE:direct assay:GO:0051787 misfolded
protein binding [PMID:18843051]"
/experiment="EXISTENCE:mutant phenotype:GO:0006515 protein
quality control for misfolded or incompletely synthesized
proteins [PMID:18843051]"
/note="Subunit of the mitochondrial (mt) i-AAA protease
supercomplex; i-AAA degrades misfolded mitochondrial
proteins; forms a subcomplex with Mgr1p that binds to
substrates to facilitate proteolysis; required for growth
of cells lacking mtDNA"
/codon_start=1
/product="Mgr3p"
/protein_id="NP_013833.1"
/db_xref="GeneID:855142"
/db_xref="SGD:S000004721"
/translation="MLLQGMRLSQRLHKRHLFASKILTWTTNPAHIRHLHDIRPPASN
FNTQESAPIPESPANSPTRPQMAPKPNLKKKNRSLMYSIIGVSIVGLYFWFKSNSRKQ
KLPLSAQKVWKEAIWQESDKMDFNYKEALRRYIEALDECDRSHVDLLSDDYTRIELKI
AEMYEKLNMLEEAQNLYQELLSRFFEALNVPGKVDESERGEVLRKDLRILIKSLEINK
DIESGKRKLLQHLLLAQEEILSKSPELKEFFENRKKKLSMVKDINRDPNDDFKTFVSE
ENIKFDEQGYMILDLEKNSSAWEPFKEEFFTARDLYTAYCLSSKDIAAALSCKITSVE
WMVMADMPPGQILLSQANLGSLFYLQAEKLEADLNQLEQKKSKESNQELDMGTYIKAV
RFVRKNRDLCLERAQKCYDSVIAFAKRNRKIRFHVKDQLDPSIAQSIALSTYGMGVLS
LHEGVLAKAEKLFKDSITMAKETEFNELLAEAEKELEKTTVLKAAKKEGLN"
gene complement(<499456..>500688)
/gene="ASC1"
/locus_tag="YMR116C"
/gene_synonym="ASU9; CPC2; NAD1"
/db_xref="GeneID:855143"
mRNA complement(join(<499456..499878,500152..>500688))
/gene="ASC1"
/locus_tag="YMR116C"
/gene_synonym="ASU9; CPC2; NAD1"
/product="guanine nucleotide-binding protein subunit beta"
/transcript_id="NM_001182616.1"
/db_xref="GeneID:855143"
CDS complement(join(499456..499878,500152..500688))
/gene="ASC1"
/locus_tag="YMR116C"
/gene_synonym="ASU9; CPC2; NAD1"
/experiment="EXISTENCE:direct assay:GO:0005092
GDP-dissociation inhibitor activity [PMID:17591772]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0022627 cytosolic
small ribosomal subunit [PMID:15340087]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:27821475]"
/experiment="EXISTENCE:mutant phenotype:GO:0006521
regulation of cellular amino acid metabolic process
[PMID:34214075]"
/experiment="EXISTENCE:mutant phenotype:GO:0007186 G
protein-coupled receptor signaling pathway
[PMID:17591772]"
/experiment="EXISTENCE:mutant phenotype:GO:0010629
negative regulation of gene expression [PMID:31532761]"
/experiment="EXISTENCE:mutant phenotype:GO:0017148
negative regulation of translation [PMID:15340087]"
/experiment="EXISTENCE:mutant phenotype:GO:0061157 mRNA
destabilization [PMID:31532761]"
/experiment="EXISTENCE:mutant phenotype:GO:0070651
nonfunctional rRNA decay [PMID:28956756]"
/experiment="EXISTENCE:mutant phenotype:GO:1902660
negative regulation of glucose mediated signaling pathway
[PMID:17591772]"
/experiment="EXISTENCE:mutant phenotype:GO:1990145
maintenance of translational fidelity [PMID:30465652]"
/experiment="EXISTENCE:mutant phenotype:GO:2001125
negative regulation of translational frameshifting
[PMID:25792604]"
/experiment="EXISTENCE:physical interaction:GO:0001965
G-protein alpha-subunit binding [PMID:17591772]"
/experiment="EXISTENCE:physical interaction:GO:0007186 G
protein-coupled receptor signaling pathway
[PMID:17591772]"
/experiment="EXISTENCE:physical interaction:GO:1902660
negative regulation of glucose mediated signaling pathway
[PMID:17591772]"
/note="G-protein beta subunit and guanine dissociation
inhibitor for Gpa2p; ortholog of RACK1 that inhibits
translation; core component of the small (40S) ribosomal
subunit; required to prevent frameshifting at ribosomes
stalled at repeated CGA codons; regulates P-body formation
induced by replication stress; represses Gcn4p in the
absence of amino acid starvation; controls phosphorylation
of multiple proteins"
/codon_start=1
/product="guanine nucleotide-binding protein subunit beta"
/protein_id="NP_013834.1"
/db_xref="GeneID:855143"
/db_xref="SGD:S000004722"
/translation="MASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLIS
WKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQR
FVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNE
KADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDG
EIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRP
EFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN"
gene complement(499984..500072)
/gene="SNR24"
/locus_tag="YNCM0026C"
/db_xref="GeneID:9164952"
ncRNA complement(499984..500072)
/ncRNA_class="snoRNA"
/gene="SNR24"
/locus_tag="YNCM0026C"
/product="SNR24"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:8674114]"
/experiment="EXISTENCE:direct assay:GO:0031428 box C/D RNP
complex [PMID:10094313]"
/experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
2'-O-ribose methylation guide activity [PMID:8674114]"
/experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
methylation [PMID:8674114]"
/experiment="EXISTENCE:physical interaction:GO:0031428 box
C/D RNP complex [PMID:10733567]"
/note="C/D box small nucleolar RNA (snoRNA); commonly
referred to as U24; guides 2'-O-methylation of large
subunit (LSU) rRNA at positions C1437, C1449, and C1450"
/transcript_id="NR_132244.1"
/db_xref="GeneID:9164952"
/db_xref="SGD:S000007501"
gene complement(<501250..>501891)
/gene="SPC24"
/locus_tag="YMR117C"
/db_xref="GeneID:855144"
mRNA complement(<501250..>501891)
/gene="SPC24"
/locus_tag="YMR117C"
/product="kinetochore-associated Ndc80 complex subunit
SPC24"
/transcript_id="NM_001182617.1"
/db_xref="GeneID:855144"
CDS complement(501250..501891)
/gene="SPC24"
/locus_tag="YMR117C"
/experiment="EXISTENCE:direct assay:GO:0000776 kinetochore
[PMID:11511347]"
/experiment="EXISTENCE:direct assay:GO:0031262 Ndc80
complex [PMID:11179222|PMID:11266451]"
/experiment="EXISTENCE:mutant phenotype:GO:0000776
kinetochore [PMID:11179222]"
/experiment="EXISTENCE:mutant phenotype:GO:0007059
chromosome segregation [PMID:11266451]"
/experiment="EXISTENCE:mutant phenotype:GO:0098653
centromere clustering [PMID:11179222]"
/note="Component of the kinetochore-associated Ndc80
complex; involved in chromosome segregation, spindle
checkpoint activity, and kinetochore clustering;
evolutionarily conserved; other members include Ndc80p,
Nuf2p, Spc24p, and Spc25p"
/codon_start=1
/product="kinetochore-associated Ndc80 complex subunit
SPC24"
/protein_id="NP_013835.1"
/db_xref="GeneID:855144"
/db_xref="SGD:S000004723"
/translation="MSQKDNLLDNPVEFLKEVRESFDIQQDVDAMKRIRHDLDVIKEE
SEARISKEHSKVSESNKKLNAERINVAKLEGDLEYTNEESNEFGSKDELVKLLKDLDG
LERNIVSLRSELDEKMKLYLKDSEIISTPNGSKIKAKVIEPELEEQSAVTPEANENIL
KLKLYRSLGVILDLENDQVLINRKNDGNIDILPLDNNLSDFYKTKYIWERLGK"
gene complement(<502144..>502734)
/gene="SHH3"
/locus_tag="YMR118C"
/db_xref="GeneID:855145"
mRNA complement(<502144..>502734)
/gene="SHH3"
/locus_tag="YMR118C"
/product="protein SHH3"
/transcript_id="NM_001182618.1"
/db_xref="GeneID:855145"
CDS complement(502144..502734)
/gene="SHH3"
/locus_tag="YMR118C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:26928762]"
/note="Putative mitochondrial inner membrane hypothetical
protein; although similar to paralogous Sdh3p, Shh3p is
not a stoichiometric subunit of either succinate
dehydrogenase or of the TIM22 translocase; SHH3 has a
paralog, SDH3, that arose from the whole genome
duplication"
/codon_start=1
/product="protein SHH3"
/protein_id="NP_013836.1"
/db_xref="GeneID:855145"
/db_xref="SGD:S000004724"
/translation="MKATIQRVTSVFGVPRASVFVPRISTPFILHNYISNGRMDLFSK
EFHNGRVSKSDLWSSNKEEELLVSQRKKRPISPHLTVYEPEMSWYLSSLHRISGVLLA
LGFYAFTITLGVTTIMGMDTTFQDLNKWYHEKMPKWSQWVAKGSAAYLFAFHFGNGIR
HLIWDMGYELTNRGVIKTGSIVLAGTLVLGTYLLAQ"
repeat_region 503192..503389
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007123"
rep_origin 503389..503771
/note="ARS1319; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130189"
repeat_region 503771..504141
/note="Ty4 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007128"
repeat_region 504346..504677
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007124"
gene 504895..505008
/locus_tag="YNCM0027W"
/db_xref="GeneID:855146"
tRNA join(504895..504932,504965..505008)
/locus_tag="YNCM0027W"
/product="tRNA-Leu"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:855146"
/db_xref="SGD:S000006644"
gene <505333..>507207
/gene="ASI1"
/locus_tag="YMR119W"
/db_xref="GeneID:855147"
mRNA <505333..>507207
/gene="ASI1"
/locus_tag="YMR119W"
/product="putative ubiquitin-protein ligase ASI1"
/transcript_id="NM_001182619.1"
/db_xref="GeneID:855147"
CDS 505333..507207
/gene="ASI1"
/locus_tag="YMR119W"
/EC_number="2.3.2.27"
/experiment="EXISTENCE:direct assay:GO:0005637 nuclear
inner membrane [PMID:16735580|PMID:27831485]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0097658 Asi complex
[PMID:25236469]"
/experiment="EXISTENCE:genetic interaction:GO:0004842
ubiquitin-protein transferase activity [PMID:11454748]"
/experiment="EXISTENCE:genetic interaction:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:11454748]"
/experiment="EXISTENCE:mutant phenotype:GO:0004842
ubiquitin-protein transferase activity [PMID:25236469]"
/experiment="EXISTENCE:mutant phenotype:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:25236469]"
/experiment="EXISTENCE:mutant phenotype:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:25253722]"
/experiment="EXISTENCE:mutant phenotype:GO:0071230
cellular response to amino acid stimulus [PMID:17085444]"
/note="Subunit of the inner nuclear membrane Asi ubiquitin
ligase complex; the Asi complex targets both misfolded
proteins of the inner nuclear membrane-associated
degradation (INMAD) pathway and regulators of sterol
biosynthesis for ubiquitin-mediated degradation; acts with
Asi2p and Asi3p to ensure the fidelity of SPS-sensor
signaling by targeting latent unprocessed forms of Stp1p
and Stp2p, maintaining the repressed state of gene
expression in the absence of inducing amino acids"
/codon_start=1
/product="putative ubiquitin-protein ligase ASI1"
/protein_id="NP_013837.1"
/db_xref="GeneID:855147"
/db_xref="SGD:S000004725"
/translation="MNSSTSSENVFINSFSYLNQTSQAVISGNSTFANVINFPYRLGL
SFIGAVNLQYEQTVKSEEIPPTLRSVFDTIGFFFSPYAIFCFVIAIVLNRFVVFYAVL
NNGSRRTLPLWLSNVFHVSAVVVLAMVSLGPLTLGKDFKILGDPAFAQEKFLLNIFYA
FAYSYCVETIFTIMRNSSPLEGTDYSLFELSIQFYTMTNNNTKFLDSPDYIIDCSMAI
LSRILIHLVEIFRLRNYRLLFSTIMNLCHICYLGIRVKQGGWKSLPFSVKFRHFPKLF
SVSIICLSLLIFKLSCLIRWDPFGKSRNSCELLQFYPLSRNWKKYLNYTGEEDFSAMA
TKFALLLCSGTELMEKGIRREFPAINIPDNVNEKFFISGYLNELSKPYKENTSISFPK
KNSSILKQRFFLMFPKSIIWIMKKLVGQVFFGFRDNKDEDIPDNDPSKMLKITKTNSL
NNSAGHKEDIELELLNTSDDEYSEDYEPSEVESLGDSDEENLEEDSLIFNETRDALLD
LFSSEDNEVHTDYNWIMSTSRILQQKLLSDKTLTRASILDTKLSEVDETFGTESDFDL
SCAVCKVNERNTVLWPCRCFAICEDCRISLGLRGFSTCVCCRSKVHGYCKVHPVSDSK
"
gene complement(<507502..>509280)
/gene="ADE17"
/locus_tag="YMR120C"
/db_xref="GeneID:855149"
mRNA complement(<507502..>509280)
/gene="ADE17"
/locus_tag="YMR120C"
/product="bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase ADE17"
/transcript_id="NM_001182621.1"
/db_xref="GeneID:855149"
CDS complement(507502..509280)
/gene="ADE17"
/locus_tag="YMR120C"
/EC_number="2.1.2.3"
/EC_number="3.5.4.10"
/experiment="EXISTENCE:direct assay:GO:0003937 IMP
cyclohydrolase activity [PMID:10877846]"
/experiment="EXISTENCE:direct assay:GO:0004643
phosphoribosylaminoimidazolecarboxamide formyltransferase
activity [PMID:10877846]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:10877846]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836]"
/experiment="EXISTENCE:direct assay:GO:0006164 purine
nucleotide biosynthetic process [PMID:10877846]"
/experiment="EXISTENCE:direct assay:GO:0006189 'de novo'
IMP biosynthetic process [PMID:10877846]"
/experiment="EXISTENCE:mutant phenotype:GO:0006164 purine
nucleotide biosynthetic process [PMID:10877846]"
/experiment="EXISTENCE:mutant phenotype:GO:0006189 'de
novo' IMP biosynthetic process [PMID:10877846]"
/note="Enzyme of 'de novo' purine biosynthesis; contains
both 5-aminoimidazole-4-carboxamide ribonucleotide
transformylase and inosine monophosphate cyclohydrolase
activities; ADE17 has a paralog, ADE16, that arose from
the whole genome duplication; ade16 ade17 mutants require
adenine and histidine"
/codon_start=1
/product="bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase ADE17"
/protein_id="NP_013839.1"
/db_xref="GeneID:855149"
/db_xref="SGD:S000004727"
/translation="MANYTKTAILSVYDKTGLLDLARGLIEKNVRILASGGTARMIRD
AGFPIEDVSAITHAPEMLGGRVKTLHPAVHGGILARDIDSDEKDLKEQHIEKVDYVVC
NLYPFKETVAKVGVTIPEAVEEIDIGGVTLLRAAAKNHARVTILSDPKDYSEFLSELS
SNGEISQDLRNRLALKAFEHTADYDAAISDFFRKQYSEGQAQITLRYGANPHQKPAQA
YVSQQDSLPFKVLCGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVG
IPLSDVEKQVYFVADIENLSPLACAYARARGADRMSSFGDWIALSNIVDVPTAKIISR
EVSDGVIAPGYEPEALAILSKKKGGKYCILQIDPNYVPEAVERRQVYGVTLEQKRNDA
IINQSTFKEIVSQNKNLTEQAIIDLTVATIAIKYTQSNSVCYARNGMVVGLGAGQQSR
IHCTRLAGDKADNWWFRQHPRVLEIKWAKGVKRPEKSNAIDLFVTGQIPTEEPELSEY
QSKFEEIPKPFTPEERKEWLSKLTNVSLSSDAFFPFPDNVYRAVKSGVKYIAAPSGSV
MDKVVFSAADSFDLVYVENPIRLFHH"
gene complement(<509734..>510348)
/gene="RPL15B"
/locus_tag="YMR121C"
/db_xref="GeneID:855150"
mRNA complement(<509734..>510348)
/gene="RPL15B"
/locus_tag="YMR121C"
/product="ribosomal 60S subunit protein L15B"
/transcript_id="NM_001182622.1"
/db_xref="GeneID:855150"
CDS complement(509734..510348)
/gene="RPL15B"
/locus_tag="YMR121C"
/experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic
translation [PMID:6814480]"
/experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
[PMID:6337137]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:6814480]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:6814480]"
/experiment="EXISTENCE:mutant phenotype:GO:0016236
macroautophagy [PMID:19793921]"
/note="Ribosomal 60S subunit protein L15B; binds to 5.8 S
rRNA; homologous to mammalian ribosomal protein L15, no
bacterial homolog; RPL15B has a paralog, RPL15A, that
arose from the whole genome duplication; relocalizes from
nucleus to nucleolus upon DNA replication stress"
/codon_start=1
/product="ribosomal 60S subunit protein L15B"
/protein_id="NP_013840.1"
/db_xref="GeneID:855150"
/db_xref="SGD:S000004728"
/translation="MGAYKYLEELERKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTR
PDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATA
EERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICNPVHKHRE
ARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK"
gene complement(<510701..>511075)
/locus_tag="YMR122C"
/db_xref="GeneID:855151"
mRNA complement(<510701..>511075)
/locus_tag="YMR122C"
/product="uncharacterized protein"
/transcript_id="NM_001348867.1"
/db_xref="GeneID:855151"
CDS complement(510701..511075)
/locus_tag="YMR122C"
/note="hypothetical protein; conserved among S. cerevisiae
strains; YMR122C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335807.1"
/db_xref="GeneID:855151"
/db_xref="SGD:S000004729"
/translation="MLRQFGGVFRNLRVPERTNALLFAQHKGDERHSGQRAFDGSKFR
LEAKRCFTAICIITVARRDRLGVLVCGKNTASTLPYLPANRIFRLPKVQIRKMFPIGC
ATFLSREYIITALLVSYCHLCV"
gene <511315..>511569
/gene="NCW1"
/locus_tag="YMR122W-A"
/db_xref="GeneID:855152"
mRNA <511315..>511569
/gene="NCW1"
/locus_tag="YMR122W-A"
/product="Ncw1p"
/transcript_id="NM_001184445.1"
/db_xref="GeneID:855152"
CDS 511315..511569
/gene="NCW1"
/locus_tag="YMR122W-A"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095]"
/note="hypothetical protein; green fluorescent protein
(GFP)-fusion protein localizes to the cytoplasm and
endoplasmic reticulum"
/codon_start=1
/product="Ncw1p"
/protein_id="NP_061493.1"
/db_xref="GeneID:855152"
/db_xref="SGD:S000007524"
/translation="MASSTSTSASASSSIKTNSALVSNNVVAASSVSATSTASSSAAK
NTTSSSKNAAPGMVANPVSSKYGIIMAAFAAVSFVLGTGI"
gene <513593..>513961
/gene="PKR1"
/locus_tag="YMR123W"
/db_xref="GeneID:855153"
mRNA <513593..>513961
/gene="PKR1"
/locus_tag="YMR123W"
/product="Pkr1p"
/transcript_id="NM_001182624.1"
/db_xref="GeneID:855153"
CDS 513593..513961
/gene="PKR1"
/locus_tag="YMR123W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:16926153]"
/experiment="EXISTENCE:genetic interaction:GO:0070072
vacuolar proton-transporting V-type ATPase complex
assembly [PMID:16926153]"
/experiment="EXISTENCE:mutant phenotype:GO:0070072
vacuolar proton-transporting V-type ATPase complex
assembly [PMID:16926153]"
/note="V-ATPase assembly factor; functions with other
V-ATPase assembly factors in the ER to efficiently
assemble the V-ATPase membrane sector (V0); protein
abundance increases in response to DNA replication stress"
/codon_start=1
/product="Pkr1p"
/protein_id="NP_013842.1"
/db_xref="GeneID:855153"
/db_xref="SGD:S000004730"
/translation="MANFFVRLWESVFEPGTSPQLIIATHVSFVALLLTLIWLIYATN
GNIHFYALFCISLLLWITVIWFINELSHVKLKDNDELDKDANKKDDSAIKEDSEDKQE
SGKSTSTARRTQAQSRSRKA"
gene <514456..>517287
/gene="EPO1"
/locus_tag="YMR124W"
/db_xref="GeneID:855154"
mRNA <514456..>517287
/gene="EPO1"
/locus_tag="YMR124W"
/product="Epo1p"
/transcript_id="NM_001182625.1"
/db_xref="GeneID:855154"
CDS 514456..517287
/gene="EPO1"
/locus_tag="YMR124W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0061163 endoplasmic
reticulum polarization [PMID:25083872]"
/experiment="EXISTENCE:physical interaction:GO:0005935
cellular bud neck [PMID:25083872]"
/note="Protein involved in septin-ER tethering; interacts
with ER membrane protein, Scs2p, and Shs1p, a septin ring
component, at bud neck to create ER diffusion barrier;
GFP-fusion protein localizes to the cell periphery,
cytoplasm, bud, and bud neck; interacts with Crm1p in
two-hybrid assay; YMR124W has a paralog, YLR031W, that
arose from the whole genome duplication"
/codon_start=1
/product="Epo1p"
/protein_id="NP_013843.1"
/db_xref="GeneID:855154"
/db_xref="SGD:S000004731"
/translation="MDAGLSTMATRNGQSSARVKLRNNLLNNDIGNIDIRDETPISRN
GNDSNINIQPSSVPQQQQQQQQYYRNGMNEAPIQAPLQQRQIPMQNYSQQQRQQQQYN
FEYSNPHMNEIPLMQHNFTKPSLSNNRDNVNGKKASSFTQSSFSNFFKHKHQFGKSKK
NTKGTGGGGDGDDDDEVILDDSANSDLTFNDIQTFGHKGGDKYGYGGDSTPIIPTLVT
KDRGNMSNTEYRKYITNQRKTAMNAMAKQTKNGTLASLPPRAMSLQSFPNGNPLMQAP
TPHPRFQPNKMVSANYSRSNSLMSGPPGQFRQPQQQRMLPMNNYNNHPGQFQNTPPVM
PSGQQPPQQPRTLSLTNGPRYSPQNPRPFAGHQQISQRQQQQQQQLQLHPMSEGYRTM
SLQSQNVPQGFNPWSPNDNDRKAVSMKQPISQSSISSKNNSAYSIPNVQNNSLTTFSP
SSPTDATAMPNSTKQGSSPLKKQVNIDQPIENKGKLNVLQLSTPQQNELKEKERKLAE
MEKSLREREALVEEKEKERAEKNTEANEEEEISHESDDLNLRPASALETGLKDLKLES
ESAVANRASLSTFSSTFSDSPSKQRIINTRTGMYKLENSTDINEYVTAQEFPSPGKYN
SNSDNGEMNTTNEVDFDFNTSKRASLLQSIPERDPKRNVSDATIKRRESDGNGRRLSN
VNISMNQENINNDTFLYKKNNRDGHLSAVSHMSSSSRRSFISNTLPLNIDSASESDNF
VPHMDGSPSKTKSAPVSYDKDGMNASEEDFSFDNTLAKPYEPLYARRGDITSAGSTSG
EDSSQPKMITISGEQLNLITENKELMNELTLVSTELAESIKRETELEERIRLYETNNS
APSFDDSSSVSFSDFEKELRKKSSKIVQLIQQLNDERLKRFIAEEQLLLQENGTKPSS
MELVGRIENLNKLIDERDSEIEMLKGRLQ"
gene <517539..>520446
/gene="STO1"
/locus_tag="YMR125W"
/gene_synonym="CBC1; CBP80; GCR3; SUT1"
/db_xref="GeneID:855155"
mRNA join(<517539..517563,517886..>520446)
/gene="STO1"
/locus_tag="YMR125W"
/gene_synonym="CBC1; CBP80; GCR3; SUT1"
/product="Sto1p"
/transcript_id="NM_001182626.1"
/db_xref="GeneID:855155"
CDS join(517539..517563,517886..520446)
/gene="STO1"
/locus_tag="YMR125W"
/gene_synonym="CBC1; CBP80; GCR3; SUT1"
/experiment="EXISTENCE:direct assay:GO:0000184
nuclear-transcribed mRNA catabolic process,
nonsense-mediated decay [PMID:15753296]"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005844 polysome
[PMID:22072789]"
/experiment="EXISTENCE:direct assay:GO:0005846 nuclear cap
binding complex [PMID:8811086]"
/experiment="EXISTENCE:mutant phenotype:GO:0006970
response to osmotic stress [PMID:22072789]"
/experiment="EXISTENCE:physical interaction:GO:0000243
commitment complex [PMID:10072386]"
/experiment="EXISTENCE:physical interaction:GO:0000398
mRNA splicing, via spliceosome [PMID:10072386]"
/experiment="EXISTENCE:physical interaction:GO:0003729
mRNA binding [PMID:10072386]"
/note="Large subunit of the nuclear mRNA cap-binding
protein complex; interacts with Npl3p to carry nuclear
poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA
degradation and telomere maintenance; orthologous to
mammalian CBP80"
/codon_start=1
/product="Sto1p"
/protein_id="NP_013844.2"
/db_xref="GeneID:855155"
/db_xref="SGD:S000004732"
/translation="MFNRKRRGDFDEDENYRDFRPRMPKRQRIPPVVQLCKEMMPDIR
TIGESVKAFEDDIKFLSEAIMNEYGHEDYFNNALLSTLNAVVVEQPQKQAAIALLTMV
VNSKNNVAGKSIINYFFEELQKWCKQTYNDEFKSTSNETGPWNKIKLILRFLSILSPM
FLVDELINIYKSLFELSIELNNLDPGNRVPLSEAIYTNTLLNIPYLFFFNRNNDGLRT
KVEELLAYVEQNYLVKTTDINLLREYNGEPPYEMVELVRVVLPNVKKALINNLEQLNE
LFPDWNHLLTPQTGDEGFNDALTLPSVDDLKSFVRLNKNFGSVDSMWKTPRYAFHVYL
PNSAGNFETVVPISTYAGQLFNDIIIDLVESLEFNRKEVARQVITLDLFFKAGIFTEP
GESIAQLIATYEENPLAPTFKIEDLAIETILGLIFKLPSVSQPFAYFYTLLVDICQNS
PKAIAPVFGRAFRFFYSHLDSLDFELKLRYLDWFSIQMSNFNFSWKWNEWEDDSIKFG
KYFYNPKVNFAKNLIQKELRLTSNFSEVEDSLPQEFTKYLDTSYIPRDQLINYYQSLF
TGYTVEEDSVRKNDLYFRQEGVPMENTVRKILDYTHKANNSREVTELESILGELKNEY
GSIISDFNRFVIILLVQAVTDSGSRSLSHANKYINDLKEDLKTIFAKIELDIETKEYI
IIEAVLTFWNANPQTGFLVADAFKYAGLLTSRTIFTFIFNETGLKNNGLIEATAIEAV
FRNLSQQISEENESGNNFEFVFERLCTIANSTIDLLDVNADEDIEIPKVNGEMDIDDI
EDDKLDLKWKYFTVIGFIKSILRRYSHEYRELADKFIANIDNAIPHESTRRTISNWIQ
ETKEV"
gene complement(<520761..>521789)
/gene="DLT1"
/locus_tag="YMR126C"
/db_xref="GeneID:855156"
mRNA complement(<520761..>521789)
/gene="DLT1"
/locus_tag="YMR126C"
/product="Dlt1p"
/transcript_id="NM_001182627.1"
/db_xref="GeneID:855156"
CDS complement(520761..521789)
/gene="DLT1"
/locus_tag="YMR126C"
/note="hypothetical protein; mutant sensitive to
6-azauracil (6AU) and mycophenolic acid (MPA)"
/codon_start=1
/product="Dlt1p"
/protein_id="NP_013845.1"
/db_xref="GeneID:855156"
/db_xref="SGD:S000004733"
/translation="MSGFAKLKSWLYKASLFVSLILLIGFSVVLPIDSIAQASKSENN
AFNTFIVVGALVVFGVFCIFIIIGRMLFHKSCLKDIPRRYIPITPADLPHRSSREAVL
QNMERSKELTILLKKPKDPVIHDGLEPPRRCDYPLDEKLFPEYLNYADCIKSLTDRLK
YHGLFLNNLDVRMNLEDTFADVVNSQFVNHNANKIQLEKAKEFIDLYETIRFSGKDVT
RDQFIKFVKFCLYFGEVSLTRDTSFANLHNFRLNGSSNNIGRTESKYSINPFDENEYA
QDDMHYFPEPPTHLVRESSISTVARHVSSGVDLTNSEEHPLDTDSDCNALRLKLSKAD
SYRSVIRH"
gene complement(<522329..>523345)
/gene="SAS2"
/locus_tag="YMR127C"
/gene_synonym="KAT8"
/db_xref="GeneID:855157"
mRNA complement(<522329..>523345)
/gene="SAS2"
/locus_tag="YMR127C"
/gene_synonym="KAT8"
/product="histone acetyltransferase"
/transcript_id="NM_001182628.1"
/db_xref="GeneID:855157"
CDS complement(522329..523345)
/gene="SAS2"
/locus_tag="YMR127C"
/gene_synonym="KAT8"
/EC_number="2.3.1.48"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:11731479]"
/experiment="EXISTENCE:direct assay:GO:0004402 histone
acetyltransferase activity [PMID:12626510]"
/experiment="EXISTENCE:direct assay:GO:0016407
acetyltransferase activity [PMID:11731479]"
/experiment="EXISTENCE:direct assay:GO:0031509
subtelomeric heterochromatin formation [PMID:11731479]"
/experiment="EXISTENCE:direct assay:GO:0033255 SAS
acetyltransferase complex [PMID:12626510]"
/experiment="EXISTENCE:mutant phenotype:GO:0030466 silent
mating-type cassette heterochromatin formation
[PMID:27655944]"
/experiment="EXISTENCE:physical interaction:GO:0033255 SAS
acetyltransferase complex [PMID:15788653]"
/note="Histone acetyltransferase (HAT) catalytic subunit
of the SAS complex; acetylates free histones and
nucleosomes and regulates transcriptional silencing;
member of the MYSTacetyltransferase family; other members
are Sas4p and Sas5p"
/codon_start=1
/product="histone acetyltransferase"
/protein_id="NP_013846.1"
/db_xref="GeneID:855157"
/db_xref="SGD:S000004734"
/translation="MARSLSQSLTATTQKLKGKKNGGKGKNKPSAKIKKTQKEMLYGI
LNERNIRQIQFGLNKKFSTWYGSAVYFDPETKRLGCSETKGQLSSVSNSQYWLDTLFV
CEYCFKYTDDQTRFVGHVASCPFQYRVPGKIKYKSPEYTIRRVKGSKYQLFCQCLCLF
TKLYLDNKSMYFKVDHYEFYIVYETGSTKPMGFFSKDLVSYQQNNLACILIFPPYQRR
GLGLLLIEFSYKLSQLEGVISGPEVPLSPFGLIGYLKYWSQILCWHLIEGDLAHYDKV
TLEDLSIVTGMRVNDVILTLKHLNCIGENNQIYLQSLNSWLKLHGTKRNWFKLKDEYL
LIDD"
gene <523696..>527499
/gene="ECM16"
/locus_tag="YMR128W"
/gene_synonym="DHR1"
/db_xref="GeneID:855158"
mRNA <523696..>527499
/gene="ECM16"
/locus_tag="YMR128W"
/gene_synonym="DHR1"
/product="ATP-dependent RNA helicase ECM16"
/transcript_id="NM_001182629.1"
/db_xref="GeneID:855158"
CDS 523696..527499
/gene="ECM16"
/locus_tag="YMR128W"
/gene_synonym="DHR1"
/EC_number="3.6.4.13"
/experiment="EXISTENCE:direct assay:GO:0003724 RNA
helicase activity [PMID:10982841]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:10982841|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:12150911]"
/experiment="EXISTENCE:direct assay:GO:0032040
small-subunit processome [PMID:12068309]"
/experiment="EXISTENCE:direct assay:GO:0042254 ribosome
biogenesis [PMID:10982841]"
/experiment="EXISTENCE:mutant phenotype:GO:0000462
maturation of SSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]"
/note="Essential DEAH-box ATP-dependent RNA helicase
specific to U3 snoRNP; functions with methyltransferase
Bud23p; predominantly nucleolar in distribution; required
for 18S rRNA synthesis"
/codon_start=1
/product="ATP-dependent RNA helicase ECM16"
/protein_id="NP_013847.1"
/db_xref="GeneID:855158"
/db_xref="SGD:S000004735"
/translation="MGTYRKRFNEKARSGHMAKLKELKRIRNKQFTRQDENDERVENP
DSAPAESSTTEPNANAEILEPLTEEEKKMKKRKLQELFTPKESKVSRLKKKRLDKFIE
HQLKREERKTIIGKLQDYKIDTSLLTSSKRLGEGRQTKKEEFKEALSLERQGRGNEQT
NEILYEEYEPKVWDEYGEGGSSEDDDGEDDFEASFGSMPKPTDNEEKKSSGFIDHRPA
KFGGSGLSFGFSNIKVINKESKTPKKKYNWRQRVEMEELKKHGKEDEMDFDTTSEDDD
EEEDQEEEDKMHPSENPLEEVESADSETGSEKFDQNDVANEFKDWANQEIKKLEGRDQ
ELVTPTLNIDYKPIIRKEDLDDGLQEAYVPINENSTRKAFYVEVSRSDEIQKARIQLP
VFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGMVGITQP
RRVAAVSMAERVANELGDHGHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFKLT
KYSSIIIDEAHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSD
FSENKTLFPIAPPVLQVDARQFPVSIHFNRRTAFNYTDEAFRKTCKIHQKLPPGAILV
FLTGQQEITHMVKRLRKEFPFKKNSKYNKDLETPVSKMGINSKTTDLEAEDIDFSVQV
IDQDKFKSAIRYEEDEGNSGNGEDEEDEEEEGFEEVLTEGQTANDPLYVLPLYSLLPT
KEQMRVFQKPPQGSRLCIVATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEV
GWVSKASANQRSGRAGRTGPGHCYRLYSSAVFEHDFEQFSKPEILRMPVESIVLQMKS
MAIHNIINFPFPTPPDRVALSKAIQLLQYLGALDNKEMITEDGKKMSLFPLSPRFSKM
LLVSDEKACLPYIVAIVSALSVGDPFINEFELGINEISRKPNPDENLDDKIREHDEST
PGMDPELKKELRSKFYKSRSQFSKLDKFSDVFRLLSVVSAMDYVPKEQKEIFMKKNFL
RGKLMEEIVKLRKQLMYIIKSNTSKENIAVVIRNEDLKSDIPSVIQIKLLKQMICAGF
VDHVAVRADVLFPDDAKITNRTSIINIPYIPVLATRTPNIEDCFVYIHPTSILNNLGE
MPPKYMLYYSLHLGGNNKTRMNTLCDIASTPLANIARKGLLLTYSKPLTGQGLKTVNL
SPTERYCYVVPRFGSTVDNDLKIGWDLNPIAVHQKKQKGQWTVIKFITRKGFQTITGE
EKEKK"
gene <527804..>531817
/gene="POM152"
/locus_tag="YMR129W"
/db_xref="GeneID:855159"
mRNA <527804..>531817
/gene="POM152"
/locus_tag="YMR129W"
/product="Pom152p"
/transcript_id="NM_001182630.1"
/db_xref="GeneID:855159"
CDS 527804..531817
/gene="POM152"
/locus_tag="YMR129W"
/experiment="EXISTENCE:direct assay:GO:0005641 nuclear
envelope lumen [PMID:9988776]"
/experiment="EXISTENCE:direct assay:GO:0005643 nuclear
pore [PMID:7559775|PMID:8138573|PMID:9988776]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0006606 protein
import into nucleus [PMID:7559775]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0043495
protein-membrane adaptor activity [PMID:7559775]"
/experiment="EXISTENCE:direct assay:GO:0070762 nuclear
pore transmembrane ring
[PMID:10684247|PMID:7559775|PMID:19414609]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0006999
nuclear pore organization [PMID:19414609]"
/experiment="EXISTENCE:genetic interaction:GO:0017056
structural constituent of nuclear pore [PMID:16682526]"
/experiment="EXISTENCE:genetic interaction:GO:0030474
spindle pole body duplication [PMID:20713690]"
/experiment="EXISTENCE:physical interaction:GO:0070762
nuclear pore transmembrane ring [PMID:19414609]"
/note="Glycoprotein subunit of transmembrane ring of
nuclear pore complex; contributes to nucleocytoplasmic
transport, nuclear pore complex (NPC) biogenesis and
spindle pole body duplication; type II transmembrane
protein composed of N-terminal cytosolic and C-terminal
nuclear envelope lumenal domains; homologous to human
NUP210"
/codon_start=1
/product="Pom152p"
/protein_id="NP_013848.1"
/db_xref="GeneID:855159"
/db_xref="SGD:S000004736"
/translation="MEHRYNVFNDTPRGNHWMGSSVSGSPRPSYSSRPNVNTTRRFQY
SDDEPAEKIRPLRSRSFKSTESNISDEKSRISERDSKDRYINGDKKVDIYSLPLISTD
VLEISKQRTFAVILFLIIQCYKIYDLVILKSGLPLSGLLFKNYRFNFISKYFIIDSFF
LYVLPSFNIPRLTFKPWVVYLQILAMLLLNIFISSDHEFVLISLIMTTWRKLYTKELS
VTGSAINHHRIFDSSAHFKGALTIKILPENTAMFNPLHESYCLPMDTNLFKINSIDVP
IRINSTEEIEYIELEYRDLYTNSVELRSLSKKDFKIIDNPKSFLKKDQSVLKSHSNDF
EEGSTIRYLAVTLQDIGFYQIKKIVDSKKLNLKIHQSHLVVPYCPIASITGTGSNDRC
IGDSDNVSFEIQGVPPMKLAYSKIVNGQTFSYVDSSLQPEYFESPLQSSKSKQSFTQG
ELNDLKWGRNQPVNINLDSSITQDGKFAYKIDKITDGLGNVVDFTSLPEELKKRYDLS
YNFNVHEVPRAALEERFDPKSPTKRSIAIVFEEIKNWISDIPYVISLSYTDAQDKSKK
IMNVTTDSLTKVLQADLPGSYNLEYIESKFCPGEIVGKSNVLVTMPVAPTMEVKSFPI
LDQCVGQVGLNFELSFTGAPPYYYNTKIYKLENGERKLYDAKRYTSEGTRNRFSYSPP
KEGNYEIVFDTVSNKLFTEPIKLEPVKEYTFKTSMRVKPSASLKLHHDLKLCLGDHSS
VPVALKGQGPFTLTYDIIETFSSKRKTFEIKEIKTNEYVIKTPVFTTGGDYILSLVSI
KDSTGCVVGLSQPDAKIQVRRDIPSAAFNFFEPIKEAKIKHGSVTEIPLKLSGEGPFT
VKFKHMDYDGNIVKEFENKFQNSYKPALKVSKEGLYQLVDIRDSSCQGNVIYRNSLYK
VSFLEKPKFAIQDNHHITKVTENLFSKEEVCQGMEGTVDLALFGSPPFILEYDLMAPN
GHISTKKIQVATKYASLKLPNQIPGEYITTIKAIFDGNYGESDIHFREHQSELIIKQT
VHPIPDVAFADGGKTLRACAANVDQISFLEPINLKFLQGESPFSITFSVYHESTSRTD
QYTIDNIDSENFSFEKLYEGMKLGNHAITIDSVVDANGCVNSLISGPRNQILVSITDA
PKIHILDPSTEYCVGDYVAYQLNGVAPFMIKYEFNGIPLKSKERSSQFVRLASEPGII
SITSLQDSSSQCIVDFTNPKLKSEFDDLSLNIHPIPSVTVSQGNYVTEDIREGDQAEV
IFSFEGTPPFSLTYVRTEETDGKHGKRRSQVVETHKVTDIYSHEYKVITSLQGTYEAI
EITDAYCFAKNDLFFNN"
gene <532119..>533027
/gene="DPI35"
/locus_tag="YMR130W"
/db_xref="GeneID:855160"
mRNA <532119..>533027
/gene="DPI35"
/locus_tag="YMR130W"
/product="Dpi35p"
/transcript_id="NM_001182631.1"
/db_xref="GeneID:855160"
CDS 532119..533027
/gene="DPI35"
/locus_tag="YMR130W"
/note="Putative mitochondrial hypothetical protein; DPI35
is not an essential gene"
/codon_start=1
/product="Dpi35p"
/protein_id="NP_013849.1"
/db_xref="GeneID:855160"
/db_xref="SGD:S000004737"
/translation="MTYPKRIPINAWSEVHRVARPLIITFDAYNTLYATKLPVMEQYC
IVGRKYGIKANPSTLTNNFPHVFKKLKEDYPQYGKYSGIKPEQWWSILIRNVFAPNEI
PDEMINEILMRFEGFDSYFVYPDLIKFLKDLKSRHPDVILGIVSNTDPIFYKLLKNIG
LFETFSGHIYLSYELNLAKPDRAIFQYALDDIISKQPHLLEKYTREEILQHCFHIGDE
LKNDLEGAEAAGWTGILLDRNDKYGFLSNSISKPMRDEYKLSIDKIDNNSINTWEANT
KQTDTLQLSERKYVVSNLEVLEELFP"
gene complement(<533163..>534698)
/gene="RRB1"
/locus_tag="YMR131C"
/db_xref="GeneID:855161"
mRNA complement(<533163..>534698)
/gene="RRB1"
/locus_tag="YMR131C"
/product="ribosome biosynthesis protein RRB1"
/transcript_id="NM_001182632.1"
/db_xref="GeneID:855161"
CDS complement(533163..534698)
/gene="RRB1"
/locus_tag="YMR131C"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:10684247]"
/experiment="EXISTENCE:direct assay:GO:0051082 unfolded
protein binding [PMID:26112308]"
/experiment="EXISTENCE:mutant phenotype:GO:0042254
ribosome biogenesis [PMID:11728313]"
/note="Specific assembly chaperone for ribosomal protein
Rpl3p; co-translationally associates with nascent Rpl3p,
preventing aggregation, and facilitating nuclear import;
required for biogenesis of preribosomal particles;
essential gene; contains five WD-repeat motifs"
/codon_start=1
/product="ribosome biosynthesis protein RRB1"
/protein_id="NP_013850.1"
/db_xref="GeneID:855161"
/db_xref="SGD:S000004738"
/translation="MSKRSIEVNEEQDRVVSAKTESHSVPAIPASEEQDAPKNDLEEQ
LSDEFDSDGEIIEIDGDDEINDEDDLRKKQEEAETLVQKDQSEGNKEKIQELYLPHMS
RPLGPDEVLEADPTVYEMLHNVNMPWPCLTLDVIPDTLGSERRNYPQSILLTTATQSS
RKKENELMVLALSNLAKTLLKDDNEGEDDEEDDEDDVDPVIENENIPLRDTTNRLKVS
PFAISNQEVLTATMSENGDVYIYNLAPQSKAFSTPGYQIPKSAKRPIHTVKNHGNVEG
YGLDWSPLIKTGALLSGDCSGQIYFTQRHTSRWVTDKQPFTVSNNKSIEDIQWSRTES
TVFATAGCDGYIRIWDTRSKKHKPAISVKASNTDVNVISWSDKIGYLLASGDDNGTWG
VWDLRQFTPSNADAVQPVAQYDFHKGAITSIAFNPLDESIVAVGSEDNTVTLWDLSVE
ADDEEIKQQAAETKELQEIPPQLLFVHWQKEVKDVKWHKQIPGCLVSTGTDGLNVWKT
ISV"
gene complement(<534944..>535570)
/gene="JLP2"
/locus_tag="YMR132C"
/db_xref="GeneID:855162"
mRNA complement(<534944..>535570)
/gene="JLP2"
/locus_tag="YMR132C"
/product="Jlp2p"
/transcript_id="NM_001182633.1"
/db_xref="GeneID:855162"
CDS complement(534944..535570)
/gene="JLP2"
/locus_tag="YMR132C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="hypothetical protein; contains sequence that
closely resembles a J domain (typified by the E. coli DnaJ
protein)"
/codon_start=1
/product="Jlp2p"
/protein_id="NP_013851.1"
/db_xref="GeneID:855162"
/db_xref="SGD:S000004739"
/translation="MVYFYESKPTEYSTPYQIVMGKDKFENDLLIKWSYRELNYVWFH
ADKYSSGHVYLKLRPNEKTIDDIPQEVICDCLQLCKSESIQGNKMPQCTILITPWHNL
RKNRYMNPGEVSFKSLRQCRKMECGARDNKILNRLAKTRVELFNNVEATLNEAKKTKN
GDFFVNYIESNRSNLIEEEKLRKVAKKNQKKKNKQSKDEVTDDMQLEV"
rep_origin 535597..535844
/note="ARS1320; Autonomously Replicating Sequence"
/db_xref="SGD:S000118373"
gene <536207..>537609
/gene="REC114"
/locus_tag="YMR133W"
/db_xref="GeneID:855163"
mRNA join(<536207..537448,537565..>537609)
/gene="REC114"
/locus_tag="YMR133W"
/product="Rec114p"
/transcript_id="NM_001182634.1"
/db_xref="GeneID:855163"
CDS join(536207..537448,537565..537609)
/gene="REC114"
/locus_tag="YMR133W"
/experiment="EXISTENCE:direct assay:GO:0000794 condensed
nuclear chromosome [PMID:16783010|PMID:17558514]"
/experiment="EXISTENCE:mutant phenotype:GO:0007131
reciprocal meiotic recombination [PMID:8417989]"
/note="Protein involved in early stages of meiotic
recombination; possibly involved in the coordination of
recombination and meiotic division; mutations lead to
premature initiation of the first meiotic division"
/codon_start=1
/product="Rec114p"
/protein_id="NP_013852.1"
/db_xref="GeneID:855163"
/db_xref="SGD:S000004740"
/translation="MYEYCSVVIKKYSKYTIPSFAPNGFQSMLEPPQIDKWQHLSANC
TLQFRVLLMDSRQILINVVLNNSTLLENIRLPLGDNQDLIQFSCKSPIISCKYISEEF
GPRMLRRFQMNLPNDVEFNRTVVSLKNLNFVLRTARTSIAQSTITSQVQGNNNGTKVC
FTEGPKVSSYTNPNTQFQTQNMIMDFSQRYQEESERESNNRSNITLPHDSIQIAQQIW
PNTDLNVVQSSQDLNTPMATQTVLGRPESLIVQPLEVSQSPPNTTNCLPNAENKKKKV
DTTSDFTSRKEIALCKTGLLETIHIPKERESQMQSVTGLDATPTIIWSPGKDNTAKKN
TSNKKNIDDKLTNPQKSGNTHTPDRNKEVLPNGTLNETRKEASPSEGLTIRVKNVNRN
ASRKISKRLIKEKLKDEEFMKWVNKVETVLNKMFEK"
gene <537838..>538551
/gene="ERG29"
/locus_tag="YMR134W"
/db_xref="GeneID:855164"
mRNA <537838..>538551
/gene="ERG29"
/locus_tag="YMR134W"
/product="Erg29p"
/transcript_id="NM_001182635.1"
/db_xref="GeneID:855164"
CDS 537838..538551
/gene="ERG29"
/locus_tag="YMR134W"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:14690591]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:14690591|PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process
[PMID:23892078|PMID:29773647]"
/experiment="EXISTENCE:mutant phenotype:GO:0006879
intracellular iron ion homeostasis [PMID:9180083]"
/experiment="EXISTENCE:mutant phenotype:GO:0007005
mitochondrion organization [PMID:16135527]"
/note="hypothetical protein involved in ergosterol
biosynthesis; conditional mutants produce less ergosterol,
display impaired oxygen consumption, respiratory growth,
mitochondrial iron utilization, and are more sensitive to
oxidative stress; mutant bm-8 has a growth defect on
iron-limited medium that is complemented by overexpression
of Yfh1p; protein localizes to the cytoplasm, ER and
nuclear envelope; highly conserved in ascomycetes"
/codon_start=1
/product="Erg29p"
/protein_id="NP_013853.1"
/db_xref="GeneID:855164"
/db_xref="SGD:S000004741"
/translation="MSLKDRYLNLELKLINKLQELPYVHQFIHDRISGRITLFLIVVG
TLAFFNELYITIEMSLLQKNTSEELERGRIDESLKLHRMLVSDEYHGKEYKDEKSGIV
IEEFEDRDKFFAKPVFVSELDVECNVIVDGKELLSTPLKFHVEFSPEDYENEKRPEFG
TTLRVLRLRLYHYFKDCEIYRDIIKNEGGEGARKFTISNGVKIYNHKDELLPLNIDDV
QLCFLKIDTGNTIKCEFIL"
gene complement(<538689..>540056)
/gene="GID8"
/locus_tag="YMR135C"
/gene_synonym="DCR1"
/db_xref="GeneID:855166"
mRNA complement(<538689..>540056)
/gene="GID8"
/locus_tag="YMR135C"
/gene_synonym="DCR1"
/product="glucose-induced degradation complex subunit
GID8"
/transcript_id="NM_001182636.1"
/db_xref="GeneID:855166"
CDS complement(538689..540056)
/gene="GID8"
/locus_tag="YMR135C"
/gene_synonym="DCR1"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0034657 GID complex
[PMID:16872538|PMID:18508925]"
/experiment="EXISTENCE:mutant phenotype:GO:0007089
traversing start control point of mitotic cell cycle
[PMID:15590836]"
/experiment="EXISTENCE:mutant phenotype:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:12686616]"
/experiment="EXISTENCE:mutant phenotype:GO:0045721
negative regulation of gluconeogenesis [PMID:12686616]"
/note="Subunit of GID Complex, binds strongly to central
component Vid30p; GID Complex is involved in
proteasome-dependent catabolite inactivation of
fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and
Vid28p to GID Complex; contains LisH, CTLH, and CRA
domains that mediate binding to Vid30p (LisH) and Rmd5p
and Vid28p (CTLH and CRA); dosage-dependent regulator of
START"
/codon_start=1
/product="glucose-induced degradation complex subunit
GID8"
/protein_id="NP_013854.1"
/db_xref="GeneID:855166"
/db_xref="SGD:S000004742"
/translation="MTISTLSNETTKSGSCSGQGKNGGKDFTYGKKCFTKEEWKEQVA
KYSAMGELYANKTIHYPLKIQPNSSGGSQDEGFATIQTTPIEPTLPRLLLNYFVSMAY
EDSSIRMAKELGFIRNNKDIAVFNDLYKIKERFHIKHLIKLGRINEAMEEINSIFGLE
VLEETFNATGSYTGRTDRQQQQQQQQFDIDGDLHFKLLLLNLIEMIRSHHQQENITKD
SNDFILNLIQYSQNKLAIKASSSVKKMQELELAMTLLLFPLSDSADSGSIKLPKSLQN
LYSISLRSKIADLVNEKLLKFIHPRIQFEISNNNSKFPDLLNSDKKIITQNFTVYNNN
LVNGSNGTKITHISSDQPINEKMSSNEVTAAANSVWLNQRDGNVGTGSAATTFHNLEN
KNYWNQTSELLSSSNGKEKGLEFNNYYSSEFPYEPRLTQIMKLWCWCENQLHHNQIGV
PRVEN"
gene <541199..>542881
/gene="GAT2"
/locus_tag="YMR136W"
/db_xref="GeneID:855167"
mRNA <541199..>542881
/gene="GAT2"
/locus_tag="YMR136W"
/product="Gat2p"
/transcript_id="NM_001182638.1"
/db_xref="GeneID:855167"
CDS 541199..542881
/gene="GAT2"
/locus_tag="YMR136W"
/note="Protein containing GATA family zinc finger motifs;
similar to Gln3p and Dal80p; expression repressed by
leucine"
/codon_start=1
/product="Gat2p"
/protein_id="NP_013856.1"
/db_xref="GeneID:855167"
/db_xref="SGD:S000004744"
/translation="MQAPNIYPFSQTQPQALPGFTYGPPQLVFDHSAPRVDPLHSTVT
INSPLPLQHYNGPNAHINSANNNYAYYYHHPNNNDNNNHSNNTIKNNNINSVLPAVNI
QISNNSHYRNTHQIPSAPQRLVSIIPDPHMPPNISHFQLNNIHPQMHAPVATDIHFQQ
VPVYNKTNNGIGTDNINNDKPVNSNQNEVLDNIDERSCHEINRVVSFSKHFENNELTT
TANDLNIQSTMDELAKLKSLSNSTHFRQSIATQNFHSLQNHITTIENRLASLLTDRQQ
EQQQLKQQESEKESSSPFSNKIKLPSLQELTDSISTQHLPTFYDNKRHASDTDLKSST
LHGPLYHRHAFLSTSSSSPSPTAGSAPLQKLQVPRQDDPNDKKMNISSSPFNSITYIP
NTTLSPMVQTQLKNLTTSNLNTKKKNNRGRPRAIQRQPTLTTSSHFINNSNPGAAAVS
TTTPAANSDEKNPNAKKIIEFCFHCGETETPEWRKGPYGTRTLCNACGLFYRKVTKKF
GSKSSNLLLRYRRSIDLANDRRIPDFITIPNRFIHDMDNDQTLDSEYNTILQ"
rep_origin 542881..542978
/note="ARS1321; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130190"
gene complement(<542978..>544963)
/gene="PSO2"
/locus_tag="YMR137C"
/gene_synonym="SNM1"
/db_xref="GeneID:855168"
mRNA complement(<542978..>544963)
/gene="PSO2"
/locus_tag="YMR137C"
/gene_synonym="SNM1"
/product="DNA cross-link repair protein PSO2"
/transcript_id="NM_001182639.1"
/db_xref="GeneID:855168"
CDS complement(542978..544963)
/gene="PSO2"
/locus_tag="YMR137C"
/gene_synonym="SNM1"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:35482533]"
/experiment="EXISTENCE:direct assay:GO:0008409 5'-3'
exonuclease activity [PMID:15590324|PMID:35482533]"
/experiment="EXISTENCE:genetic interaction:GO:0036297
interstrand cross-link repair [PMID:22912599]"
/experiment="EXISTENCE:mutant phenotype:GO:0003684 damaged
DNA binding [PMID:7035927]"
/experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
repair [PMID:1736091|PMID:35482533]"
/experiment="EXISTENCE:mutant phenotype:GO:0008409 5'-3'
exonuclease activity [PMID:15590324]"
/experiment="EXISTENCE:mutant phenotype:GO:0036297
interstrand cross-link repair [PMID:22912599]"
/note="Nuclease required for DNA single- and double-strand
break repair; acts at a post-incision step in repair of
breaks that result from interstrand cross-links produced
by a variety of mono- and bi-functional psoralen
derivatives; induced by UV-irradiation; forms nuclear foci
upon DNA replication stress; translocates to mitochondria
under genotoxic agents"
/codon_start=1
/product="DNA cross-link repair protein PSO2"
/protein_id="NP_013857.1"
/db_xref="GeneID:855168"
/db_xref="SGD:S000004745"
/translation="MSRKSIVQIRRSEVKRKRSSTASSTSEGKTLHKNTHTSSKRQRT
LTEFNIPTSSNLPVRSSSYSFSRFSCSTSNKNTEPVIINDDDHNSICLEDTAKVEITI
DTDEEELVSLHDNEVSAIENRTEDRIVTELEEQVNVKVSTEVIQCPICLENLSHLELY
ERETHCDTCIGSDPSNMGTPKKNIRSFISNPSSPAKTKRDIATSKKPTRVKLVLPSFK
IIKFNNGHEIVVDGFNYKASETISQYFLSHFHSDHYIGLKKSWNNPDENPIKKTLYCS
KITAILVNLKFKIPMDEIQILPMNKRFWITDTISVVTLDANHCPGAIIMLFQEFLANS
YDKPIRQILHTGDFRSNAKMIETIQKWLAETANETIDQVYLDTTYMTMGYNFPSQHSV
CETVADFTLRLIKHGKNKTFGDSQRNLFHFQRKKTLTTHRYRVLFLVGTYTIGKEKLA
IKICEFLKTKLFVMPNSVKFSMMLTVLQNNENQNDMWDESLLTSNLHESSVHLVPIRV
LKSQETIEAYLKSLKELETDYVKDIEDVVGFIPTGWSHNFGLKYQKKNDDDENEMSGN
TEYCLELMKNDRDNDDENGFEISSILRQYKKYNKFQVFNVPYSEHSSFNDLVKFGCKL
KCSEVIPTVNLNNLWKVRYMTNWFQCWENVRKTRAAK"
gene <545155..>545730
/gene="CIN4"
/locus_tag="YMR138W"
/gene_synonym="GTP1; UGX1"
/db_xref="GeneID:855169"
mRNA <545155..>545730
/gene="CIN4"
/locus_tag="YMR138W"
/gene_synonym="GTP1; UGX1"
/product="Arf family GTPase CIN4"
/transcript_id="NM_001182640.1"
/db_xref="GeneID:855169"
CDS 545155..545730
/gene="CIN4"
/locus_tag="YMR138W"
/gene_synonym="GTP1; UGX1"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0006457
protein folding [PMID:2407611]"
/experiment="EXISTENCE:genetic interaction:GO:0007021
tubulin complex assembly [PMID:9215891]"
/experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin
complex assembly [PMID:9215891]"
/note="GTP-binding protein involved in beta-tubulin
(Tub2p) folding; isolated as mutant with increased
chromosome loss and sensitivity to benomyl; regulated by
the GTPase-activating protein, Cin2p, the human retinitis
pigmentosa 2 (RP2) homolog"
/codon_start=1
/product="Arf family GTPase CIN4"
/protein_id="NP_013858.1"
/db_xref="GeneID:855169"
/db_xref="SGD:S000004746"
/translation="MGLLSIIRKQKLRDKEIRCLILGLDNSGKSTIVNKLLPKDEQNN
DGIMPTVGFQIHSLMIKDVTISLWDIGGQRTLRPFWDNYFDKTQAMIWCIDVSLSMRF
DETLQELKELINRDENRIGYECAVIVVLNKIDLVEDKSELHRRCLLVESELKCLFKPD
IRIELVKCSGVTGEGIDNLRDRLVESCHFTQ"
gene <546125..>547237
/gene="RIM11"
/locus_tag="YMR139W"
/gene_synonym="GSK3; MDS1"
/db_xref="GeneID:855170"
mRNA <546125..>547237
/gene="RIM11"
/locus_tag="YMR139W"
/gene_synonym="GSK3; MDS1"
/product="serine/threonine protein kinase RIM11"
/transcript_id="NM_001182641.1"
/db_xref="GeneID:855170"
CDS 546125..547237
/gene="RIM11"
/locus_tag="YMR139W"
/gene_synonym="GSK3; MDS1"
/EC_number="2.7.11.1"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity [PMID:16319894]"
/experiment="EXISTENCE:direct assay:GO:0004674 protein
serine/threonine kinase activity [PMID:9372955]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0030437
ascospore formation [PMID:10679022]"
/note="Protein kinase; required for signal transduction
during entry into meiosis; promotes the formation of the
Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p;
shares similarity with mammalian glycogen synthase kinase
3-beta; protein abundance increases in response to DNA
replication stress; RIM11 has a paralog, MRK1, that arose
from the whole genome duplication"
/codon_start=1
/product="serine/threonine protein kinase RIM11"
/protein_id="NP_013859.1"
/db_xref="GeneID:855170"
/db_xref="SGD:S000004747"
/translation="MNIQSNNSPNLSNNIVSKQVYYAHPPPTIDPNDPVQISFPTTEV
VGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYER
DSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANV
CHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYT
NQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKF
PQIKPIPLSRVFKKEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDELKLDDGKINQ
ITTDLKLLEFDENVELGHLSPDELSSVKKKLYPKSK"
gene <547714..>549183
/gene="SIP5"
/locus_tag="YMR140W"
/db_xref="GeneID:855171"
mRNA <547714..>549183
/gene="SIP5"
/locus_tag="YMR140W"
/product="Sip5p"
/transcript_id="NM_001182642.1"
/db_xref="GeneID:855171"
CDS 547714..549183
/gene="SIP5"
/locus_tag="YMR140W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:mutant phenotype:GO:0042149
cellular response to glucose starvation [PMID:10628972]"
/note="hypothetical protein; interacts with both the
Reg1p/Glc7p phosphatase and the Snf1p kinase; forms
cytoplasmic foci upon DNA replication stress"
/codon_start=1
/product="Sip5p"
/protein_id="NP_013860.1"
/db_xref="GeneID:855171"
/db_xref="SGD:S000004748"
/translation="MGNVPGKIDQEDSFNDVRPDSSYNTTSSNSVIKQYDEEASSRVR
TRRTTSLVNNILNGNNARTKTGSHLSSTSRRKTSREKELAKEAHAKQLVVRCSETVDG
GFLAPFGCYSFEKLDYDATVVKNLIIKRKLAPFYTPLQDFDESWTRDELIKIVDGLPL
HDTFDENLEEFEDVPIGNLRKSTFNELIDKSLSKKEQRRMHAKIFRARLYKKRILWQE
NENETFLERKLEMKRIGSKSSNVEDNTSSQPRKNYHLPSDDLKYTLYKNGSECPICFL
YFPGPFNYSKCCQQPICTECFVQIKRADPHFPHDEVDPTEPQTNDSEKDPNLLTSEPA
NCPYCATASFSITYQPPTNRETGIGGMPADSYVYKDAAISRADGGQPNISAITSDTIR
PDWEIKLNKERARLMRRSANATAIHISNRLIDPSHSRRRNTSHSITPIHDESTSASRS
PEPTINELEDQMVREAIRLSLEDQDNRKKSKNRNTSLRP"
gene complement(<549736..>550044)
/locus_tag="YMR141C"
/db_xref="GeneID:855172"
mRNA complement(<549736..>550044)
/locus_tag="YMR141C"
/product="uncharacterized protein"
/transcript_id="NM_001348868.1"
/db_xref="GeneID:855172"
CDS complement(549736..550044)
/locus_tag="YMR141C"
/note="hypothetical protein; conserved among S. cerevisiae
strains; YMR141C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335808.1"
/db_xref="GeneID:855172"
/db_xref="SGD:S000004749"
/translation="MSRTDTSEKRKEDFIYVSLNIYLCVRLYIMHLISSNTPKSHCSV
RFLCFFLSALAITSNRNFFRPEKMPTRIFCNDTLMVSPKTEKFLERFTNQKLAKLEVR
"
gene complement(<550206..>551207)
/gene="RPL13B"
/locus_tag="YMR142C"
/db_xref="GeneID:855173"
mRNA complement(join(<550206..550801,551204..>551207))
/gene="RPL13B"
/locus_tag="YMR142C"
/product="ribosomal 60S subunit protein L13B"
/transcript_id="NM_001182644.1"
/db_xref="GeneID:855173"
CDS complement(join(550206..550801,551204..551207))
/gene="RPL13B"
/locus_tag="YMR142C"
/experiment="EXISTENCE:curator inference:GO:0002181
cytoplasmic translation [PMID:11983894]"
/experiment="EXISTENCE:curator inference:GO:0003735
structural constituent of ribosome [PMID:11983894]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:11983894]"
/experiment="EXISTENCE:mutant phenotype:GO:0016236
macroautophagy [PMID:19793921]"
/note="Ribosomal 60S subunit protein L13B; not essential
for viability; homologous to mammalian ribosomal protein
L13, no bacterial homolog; RPL13B has a paralog, RPL13A,
that arose from the whole genome duplication"
/codon_start=1
/product="ribosomal 60S subunit protein L13B"
/protein_id="NP_013862.1"
/db_xref="GeneID:855173"
/db_xref="SGD:S000004750"
/translation="MAISKNLPILKNHFRKHWQERVKVHFDQAGKKVSRRNARAARAA
KIAPRPLDLLRPVVRAPTVKYNRKVRAGRGFTLAEVKAAGLTAAYARTIGIAVDHRRQ
NRNQEIFDANVQRLKEYQSKIIVFPRDGKAPEAEQVLSAAATFPIAQPATDVEARAVQ
DNGESAFRTLRLARSEKKFRGIREKRAREKAEAEAEKKK"
gene <551928..>552903
/gene="RPS16A"
/locus_tag="YMR143W"
/db_xref="GeneID:855174"
mRNA join(<551928..551951,552496..>552903)
/gene="RPS16A"
/locus_tag="YMR143W"
/product="ribosomal 40S subunit protein S16A"
/transcript_id="NM_001182645.1"
/db_xref="GeneID:855174"
CDS join(551928..551951,552496..552903)
/gene="RPS16A"
/locus_tag="YMR143W"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:12150911]"
/experiment="EXISTENCE:genetic interaction:GO:0000462
maturation of SSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]"
/experiment="EXISTENCE:genetic interaction:GO:0006413
translational initiation [PMID:30481328]"
/note="Protein component of the small (40S) ribosomal
subunit; homologous to mammalian ribosomal protein S16 and
bacterial S9; RPS16A has a paralog, RPS16B, that arose
from the whole genome duplication"
/codon_start=1
/product="ribosomal 40S subunit protein S16A"
/protein_id="NP_013863.2"
/db_xref="GeneID:855174"
/db_xref="SGD:S000004751"
/translation="MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEIL
RFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSK
NELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR"
gene <553362..>554390
/gene="FDO1"
/locus_tag="YMR144W"
/db_xref="GeneID:855175"
mRNA <553362..>554390
/gene="FDO1"
/locus_tag="YMR144W"
/product="Fdo1p"
/transcript_id="NM_001182646.1"
/db_xref="GeneID:855175"
CDS 553362..554390
/gene="FDO1"
/locus_tag="YMR144W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276|PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0007535 donor
selection [PMID:27257873]"
/experiment="EXISTENCE:physical interaction:GO:0007535
donor selection [PMID:27257873]"
/note="Protein involved in directionality of mating type
switching; acts with Fkh1p to control which donor
mating-type locus is inserted into MAT locus during mating
type switching; localized to the nucleus; not an essential
gene"
/codon_start=1
/product="Fdo1p"
/protein_id="NP_013864.1"
/db_xref="GeneID:855175"
/db_xref="SGD:S000004752"
/translation="MEENKLSGNKPIQLATWSNQMGSPENNGNNANNGSDVQNVIQKA
LGLIRQLNNNGLMSPMEEEHSQPSSSQETLSVDREINEQGRLRLLMQAKDDNTRKEVG
TYSSPMDSAYARENMLNVLQSLVTHLNQAVSQIQQLKFKNMILTSNENNIQSRHEVED
NLQKQQFERMKCQFLLERQSLKDQLRKRENKIVKYKQKIIEKNKKLNNLAKVLNQHAI
SDTSQIDSFSSSVKKTPSSTTTPQEMKSDMLNTLGILATHVLKDEIDDDSGNQTILQL
AAGSISNDCNTTELEITCSPEMGRTITHNRPNTKDESIQDSHGNRTLQLPKMKSFSTI
DGSIKDIK"
rep_origin 553422..554331
/gene="FDO1"
/locus_tag="YMR144W"
/note="ARS1322; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130191"
gene complement(<554793..>556475)
/gene="NDE1"
/locus_tag="YMR145C"
/gene_synonym="NDH1"
/db_xref="GeneID:855176"
mRNA complement(<554793..>556475)
/gene="NDE1"
/locus_tag="YMR145C"
/gene_synonym="NDH1"
/product="NADH-ubiquinone reductase (H(+)-translocating)
NDE1"
/transcript_id="NM_001182647.1"
/db_xref="GeneID:855176"
CDS complement(554793..556475)
/gene="NDE1"
/locus_tag="YMR145C"
/gene_synonym="NDH1"
/EC_number="1.6.5.9"
/experiment="EXISTENCE:direct assay:GO:0003954 NADH
dehydrogenase activity [PMID:9696750|PMID:9733747]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14576278|PMID:16823961|PMID:24769239|PMID:9696750|PM
ID:9733747]"
/experiment="EXISTENCE:direct assay:GO:0006116 NADH
oxidation [PMID:12032156]"
/experiment="EXISTENCE:direct assay:GO:0031966
mitochondrial membrane [PMID:31668496]"
/experiment="EXISTENCE:mutant phenotype:GO:0005739
mitochondrion [PMID:9696750|PMID:9733747]"
/experiment="EXISTENCE:mutant phenotype:GO:0019655
glycolytic fermentation to ethanol
[PMID:9696750|PMID:9733747]"
/experiment="EXISTENCE:mutant phenotype:GO:0042981
regulation of apoptotic process [PMID:31668496]"
/note="Mitochondrial external NADH dehydrogenase; type II
NAD(P)H:quinone oxidoreductase that catalyzes the
oxidation of cytosolic NADH; Nde1p and Nde2p provide
cytosolic NADH to the mitochondrial respiratory chain;
NDE1 has a paralog, NDE2, that arose from the whole genome
duplication"
/codon_start=1
/product="NADH-ubiquinone reductase (H(+)-translocating)
NDE1"
/protein_id="NP_013865.1"
/db_xref="GeneID:855176"
/db_xref="SGD:S000004753"
/translation="MIRQSLMKTVWANSSRFSLQSKSGLVKYAKNRSFHAARNLLEDK
KVILQKVAPTTGVVAKQSFFKRTGKFTLKALLYSALAGTAYVSYSLYREANPSTQVPQ
SDTFPNGSKRKTLVILGSGWGSVSLLKNLDTTLYNVVVVSPRNYFLFTPLLPSTPVGT
IELKSIVEPVRTIARRSHGEVHYYEAEAYDVDPENKTIKVKSSAKNNDYDLDLKYDYL
VVGVGAQPNTFGTPGVYEYSSFLKEISDAQEIRLKIMSSIEKAASLSPKDPERARLLS
FVVVGGGPTGVEFAAELRDYVDQDLRKWMPELSKEIKVTLVEALPNILNMFDKYLVDY
AQDLFKEEKIDLRLKTMVKKVDATTITAKTGDGDIENIPYGVLVWATGNAPREVSKNL
MTKLEEQDSRRGLLIDNKLQLLGAKGSIFAIGDCTFHPGLFPTAQVAHQEGEYLAQYF
KKAYKIDQLNWKMTHAKDDSEVARLKNQIVKTQSQIEDFKYNHKGALAYIGSDKAIAD
LAVGEAKYRLAGSFTFLFWKSAYLAMCLSFRNRVLVAMDWAKVYFLGRDSSI"
gene complement(<557481..>558524)
/gene="TIF34"
/locus_tag="YMR146C"
/db_xref="GeneID:855177"
mRNA complement(<557481..>558524)
/gene="TIF34"
/locus_tag="YMR146C"
/product="translation initiation factor eIF3 subunit i"
/transcript_id="NM_001182648.1"
/db_xref="GeneID:855177"
CDS complement(557481..558524)
/gene="TIF34"
/locus_tag="YMR146C"
/experiment="EXISTENCE:direct assay:GO:0002183 cytoplasmic
translational initiation [PMID:7798228]"
/experiment="EXISTENCE:direct assay:GO:0003743 translation
initiation factor activity [PMID:9671501]"
/experiment="EXISTENCE:direct assay:GO:0005852 eukaryotic
translation initiation factor 3 complex
[PMID:9671501|PMID:9660829]"
/experiment="EXISTENCE:direct assay:GO:0006413
translational initiation [PMID:9671501]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:26777405]"
/experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF
complex [PMID:11018020|PMID:15838098]"
/experiment="EXISTENCE:mutant phenotype:GO:0002188
translation reinitiation [PMID:20679478]"
/experiment="EXISTENCE:physical interaction:GO:0005852
eukaryotic translation initiation factor 3 complex
[PMID:9660829]"
/note="eIF3i subunit of the eukaryotic translation
initiation factor 3 (eIF3); subunit of the core complex of
eIF3; essential for translation; stimulates rate of
ribosomal scanning during translation reinitiation; eIF3
is also involved in programmed stop codon readthrough"
/codon_start=1
/product="translation initiation factor eIF3 subunit i"
/protein_id="NP_013866.1"
/db_xref="GeneID:855177"
/db_xref="SGD:S000004754"
/translation="MKAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGER
LGTLDGHTGTIWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFS
PCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAG
WSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDT
NSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEAR
FYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKSYFDFKYDVE
KAAEAKEHMQEAN"
gene <559199..>560812
/gene="LDO45"
/locus_tag="YMR147W"
/db_xref="GeneID:855178"
mRNA join(<559199..559780,560156..>560812)
/gene="LDO45"
/locus_tag="YMR147W"
/product="Ldo45p"
/transcript_id="NM_001182649.2"
/db_xref="GeneID:855178"
CDS join(559199..559780,560156..560812)
/gene="LDO45"
/locus_tag="YMR147W"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:29187528]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:29187528]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid
droplet organization [PMID:29187528]"
/note="hypothetical protein; SWAT-GFP and mCherry fusion
proteins localize to the cell periphery"
/codon_start=1
/product="Ldo45p"
/protein_id="NP_013867.2"
/db_xref="GeneID:855178"
/db_xref="SGD:S000004755"
/translation="MAARNRRKNNKKKSLLVTSAAQEKNATYVLVAEELHKKTIDLNM
GTETPLTENHENPIPAKEFKHQQKLEPIDEHDDGEDELSIKFKSMTKSSGPITEAEVQ
KLLLSYAFTSAAIQEDENEKESRHYPIKPPSPSASSLSAYFQSFVEKCKQVFYNFSLQ
TVEKLNALQNSLYEVFWIIFIYLNYWFPNVGDYVSNTFGQQDSIIIRISLSKSHFRAL
REKSSQKVQQAVKNIYFCFQEKPYLTAFKVSFAIGLVIPCSLLFLIMVSTATFFFFVY
LTLFVVIGFFSSLFIIPLLGISFVFAIGVVSFGFCSNMSFKMAQLIYVRADAFLKKVL
DKMALQTQPAQLQEPQEPLSTLRPVSNPTIPSPLRQTARPSKFVTEEDVIFEPVSAQS
AIARSLETTANKAGNKFQLS"
gene <560366..>560812
/gene="LDO16"
/locus_tag="YMR148W"
/gene_synonym="OSW5"
/db_xref="GeneID:855179"
mRNA <560366..>560812
/gene="LDO16"
/locus_tag="YMR148W"
/gene_synonym="OSW5"
/product="Ldo16p"
/transcript_id="NM_001182650.1"
/db_xref="GeneID:855179"
CDS 560366..560812
/gene="LDO16"
/locus_tag="YMR148W"
/gene_synonym="OSW5"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:29187528]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:29187528]"
/experiment="EXISTENCE:mutant phenotype:GO:0030476
ascospore wall assembly [PMID:19779569]"
/experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid
droplet organization [PMID:29187528]"
/note="hypothetical protein with possible role in spore
wall assembly; predicted to contain an N-terminal
transmembrane domain; osw5 null mutant spores exhibit
increased spore wall permeability and sensitivity to
beta-glucanase digestion"
/codon_start=1
/product="Ldo16p"
/protein_id="NP_013868.1"
/db_xref="GeneID:855179"
/db_xref="SGD:S000004756"
/translation="MVSTATFFFFVYLTLFVVIGFFSSLFIIPLLGISFVFAIGVVSF
GFCSNMSFKMAQLIYVRADAFLKKVLDKMALQTQPAQLQEPQEPLSTLRPVSNPTIPS
PLRQTARPSKFVTEEDVIFEPVSAQSAIARSLETTANKAGNKFQLS"
gene <560996..>561856
/gene="SWP1"
/locus_tag="YMR149W"
/db_xref="GeneID:855180"
mRNA <560996..>561856
/gene="SWP1"
/locus_tag="YMR149W"
/product="dolichyl-diphosphooligosaccharide-protein
glycotransferase"
/transcript_id="NM_001182651.1"
/db_xref="GeneID:855180"
CDS 560996..561856
/gene="SWP1"
/locus_tag="YMR149W"
/experiment="EXISTENCE:direct assay:GO:0005198 structural
molecule activity [PMID:29466327]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:29466327]"
/experiment="EXISTENCE:direct assay:GO:0006487 protein
N-linked glycosylation [PMID:29466327]"
/experiment="EXISTENCE:direct assay:GO:0008250
oligosaccharyltransferase complex [PMID:10358084]"
/experiment="EXISTENCE:physical interaction:GO:0006487
protein N-linked glycosylation [PMID:9405463]"
/experiment="EXISTENCE:physical interaction:GO:0008250
oligosaccharyltransferase complex [PMID:9405463]"
/note="Delta subunit of the oligosaccharyl transferase
glycoprotein complex; complex is required for N-linked
glycosylation of proteins in the endoplasmic reticulum"
/codon_start=1
/product="dolichyl-diphosphooligosaccharide-protein
glycotransferase"
/protein_id="NP_013869.1"
/db_xref="GeneID:855180"
/db_xref="SGD:S000004757"
/translation="MQFFKTLAALVSCISFVLAYVAQDVHVSFPSTAGKSRVMIGKVE
PRIGIDETVPTTITVEDPNEVIQVNFAIESTNKPFQNTLLIGLPNKNLEMAFEPEIKD
NGKLSMYKYRIDLAKLDAALLQEASRSPEPIKATLILASSTAKPKENLFREILQLNLN
FDVDHSDSSLVDKFGIKPEIHHIFHAEPKRVAKPIAVIFVLIIFITILSLIVTWLNSC
AAAFNNIPTGVTAVYFLGFIATIVGFEVIFARYYLGTSIFETLFSSLYLGAPGLLTST
KFLRSFGQTI"
gene complement(<561956..>562528)
/gene="IMP1"
/locus_tag="YMR150C"
/db_xref="GeneID:855182"
mRNA complement(<561956..>562528)
/gene="IMP1"
/locus_tag="YMR150C"
/product="endopeptidase catalytic subunit IMP1"
/transcript_id="NM_001182652.1"
/db_xref="GeneID:855182"
CDS complement(561956..562528)
/gene="IMP1"
/locus_tag="YMR150C"
/experiment="EXISTENCE:direct assay:GO:0004175
endopeptidase activity [PMID:1991446|PMID:8132591]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0006627 protein
processing involved in protein targeting to mitochondrion
[PMID:1991446]"
/experiment="EXISTENCE:physical interaction:GO:0042720
mitochondrial inner membrane peptidase complex
[PMID:8266095]"
/note="Catalytic subunit of mitochondrial inner membrane
peptidase complex; required for maturation of
mitochondrial proteins of the intermembrane space; complex
contains two catalytic subunits (Imp1p and Imp2p that
differ in substrate specificty) and Som1p"
/codon_start=1
/product="endopeptidase catalytic subunit IMP1"
/protein_id="NP_013870.1"
/db_xref="GeneID:855182"
/db_xref="SGD:S000004758"
/translation="MTVGTLPIWSKTFSYAIRSLCFLHIIHMYAYEFTETRGESMLPT
LSATNDYVHVLKNFQNGRGIKMGDCIVALKPTDPNHRICKRVTGMPGDLVLVDPSTIV
NYVGDVLVDEERFGTYIKVPEGHVWVTGDNLSHSLDSRTYNALPMGLIMGKIVAANNF
DKPFWDGSIRNIWGFKWINNTFLDVQAKSN"
gene <563096..>564193
/gene="YIM1"
/locus_tag="YMR152W"
/db_xref="GeneID:855183"
mRNA <563096..>564193
/gene="YIM1"
/locus_tag="YMR152W"
/product="Yim1p"
/transcript_id="NM_001182654.1"
/db_xref="GeneID:855183"
CDS 563096..564193
/gene="YIM1"
/locus_tag="YMR152W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:10515935|PMID:24868093]"
/experiment="EXISTENCE:direct assay:GO:0018455 alcohol
dehydrogenase [NAD(P)+] activity [PMID:32967812]"
/experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA
damage response [PMID:12077312]"
/note="Aldehyde reductase; involved in detoxification of
lignocellulose-derived aldehydes; catalyzes the reduction
of furan, aliphatic and aromatic aldehydes using either
NADH or NADPH as co-factor; membrane of the quinone
oxidoreductase subfamily of the medium-chain
dehydrogenase/reductase family; null mutant displays
sensitivity to DNA damaging agents; protein abundance
increases in response to DNA replication stress"
/codon_start=1
/product="Yim1p"
/protein_id="NP_013872.1"
/db_xref="GeneID:855183"
/db_xref="SGD:S000004760"
/translation="MSDEIVTNKSVTYVNNTTPVTITSSELDLRSCYQDDEVVIEVHA
AALNPIDFITHQLCNSYIFGKYPKTYSRDYSGVIIKAGKDVDNRWKVGDKVNGMYSHI
YGERGTLTHYLILNPAKDVPITHMVEVPKDENDPYDDFVYAAAWPLTFGTAFSTLYDF
KKDWTSDSKVLVIGASTSVSYAFVHIAKNYFNIGTVVGICSKNSIERNKKLGYDYLVP
YDEGSIVENVKKLKQSVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGN
NKADYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYPPNNFIEVGNEMIKKGTYKPP
IDSVYEFDQYKEAIDRLMSNRAKGKVVVKMK"
gene <564435..>565862
/gene="NUP53"
/locus_tag="YMR153W"
/db_xref="GeneID:855184"
mRNA <564435..>565862
/gene="NUP53"
/locus_tag="YMR153W"
/product="FG-nucleoporin NUP53"
/transcript_id="NM_001182656.1"
/db_xref="GeneID:855184"
CDS 564435..565862
/gene="NUP53"
/locus_tag="YMR153W"
/experiment="EXISTENCE:direct assay:GO:0003697
single-stranded DNA binding [PMID:17897934]"
/experiment="EXISTENCE:direct assay:GO:0005543
phospholipid binding [PMID:17897934]"
/experiment="EXISTENCE:direct assay:GO:0005643 nuclear
pore [PMID:10684247|PMID:11071914|PMID:9864357]"
/experiment="EXISTENCE:direct assay:GO:0044613 nuclear
pore central transport channel [PMID:18046406]"
/experiment="EXISTENCE:direct assay:GO:0044615 nuclear
pore nuclear basket [PMID:11071914]"
/experiment="EXISTENCE:direct assay:GO:0045893 positive
regulation of DNA-templated transcription [PMID:15817685]"
/experiment="EXISTENCE:genetic interaction:GO:0006606
protein import into nucleus [PMID:9864357]"
/experiment="EXISTENCE:genetic interaction:GO:0006607
NLS-bearing protein import into nucleus [PMID:11071914]"
/experiment="EXISTENCE:genetic interaction:GO:0006999
nuclear pore organization [PMID:19414609]"
/experiment="EXISTENCE:genetic interaction:GO:0045893
positive regulation of DNA-templated transcription
[PMID:15817685]"
/experiment="EXISTENCE:mutant phenotype:GO:0006607
NLS-bearing protein import into nucleus [PMID:11071914]"
/experiment="EXISTENCE:mutant phenotype:GO:0007088
regulation of mitotic nuclear division [PMID:14697200]"
/experiment="EXISTENCE:mutant phenotype:GO:0034501 protein
localization to kinetochore [PMID:12473689]"
/experiment="EXISTENCE:mutant phenotype:GO:0060188
regulation of protein desumoylation [PMID:17403926]"
/experiment="EXISTENCE:mutant phenotype:GO:0072417
response to spindle checkpoint signaling [PMID:12473689]"
/experiment="EXISTENCE:physical interaction:GO:0007088
regulation of mitotic nuclear division [PMID:14697200]"
/experiment="EXISTENCE:physical interaction:GO:0017056
structural constituent of nuclear pore
[PMID:17418788|PMID:9864357]"
/experiment="EXISTENCE:physical interaction:GO:0060188
regulation of protein desumoylation [PMID:17403926]"
/note="FG-nucleoporin component of central core of nuclear
pore complex (NPC); also part of the NPC nuclear basket;
contributes directly to nucleocytoplasmic transport;
involved in regulation of transcription and mitosis;
induces membrane tubulation, which may contribute to
nuclear pore assembly; NUP53 has a paralog, ASM4, that
arose from the whole genome duplication"
/codon_start=1
/product="FG-nucleoporin NUP53"
/protein_id="NP_013873.1"
/db_xref="GeneID:855184"
/db_xref="SGD:S000004762"
/translation="MADLQKQENSSRFTNVSVIAPESQGQHEQQKQQEQLEQQKQPTG
LLKGLNGFPSAPQPLFMEDPPSTVSGELNDNPAWFNNPRKRAIPNSIIKRSNGQSLSP
VRSDSADVPAFSNSNGFNNVTFGSKKDPRILKNVSPNDNNSANNNAHSSDLGTVVFDS
NEAPPKTSLADWQKEDGIFSSKTDNIEDPNLSSNITFDGKPTATPSPFRPLEKTSRIL
NFFDKNTKTTPNTASSEASAGSKEGASTNWDDHAIIIFGYPETIANSIILHFANFGEI
LEDFRVIKDFKKLNSKNMSKSPSLTAQKYPIYTGDGWVKLTYKSELSKSRALQENGII
MNGTLIGCVSYSPAALKQLASLKKSEEIINNKTSSQTSLSSKDLSNYRKTEGIFEKAK
AKAVTSKVRNAEFKVSKNSTSFKNPRRLEIKDGRSLFLRNRGKIHSGVLSSIESDLKK
REQASKSKKSWLNRLNNWLFGWNDL"
gene complement(<565999..>568182)
/gene="RIM13"
/locus_tag="YMR154C"
/gene_synonym="CPL1"
/db_xref="GeneID:855186"
mRNA complement(<565999..>568182)
/gene="RIM13"
/locus_tag="YMR154C"
/gene_synonym="CPL1"
/product="Rim13p"
/transcript_id="NM_001182657.1"
/db_xref="GeneID:855186"
CDS complement(565999..568182)
/gene="RIM13"
/locus_tag="YMR154C"
/gene_synonym="CPL1"
/experiment="EXISTENCE:direct assay:GO:0004197
cysteine-type endopeptidase activity [PMID:9928935]"
/experiment="EXISTENCE:mutant phenotype:GO:0016485 protein
processing [PMID:9928935]"
/note="Calpain-like cysteine protease; involved in
proteolytic activation of Rim101p in response to alkaline
pH; localizes to punctate structures in alkaline
conditions and in vps4 mutant; has similarity to A.
nidulans palB"
/codon_start=1
/product="Rim13p"
/protein_id="NP_013875.1"
/db_xref="GeneID:855186"
/db_xref="SGD:S000004763"
/translation="MNDWHEFNAAIKSIYCNAEGDSSSIINRLVGLAMKSEDSTFIEA
VLVLKENVSKVDKQLRFLWLTSTINSRFYPPIPISEASPVSWNKTEYCAPGTEELQRR
YPGRAKLQNEEDYSGGIEQCRDVPDCSLVASLINLRSKNLNLPLIKQISSTKYHVNLS
FNGSNKRLVTVDISQIPTSVDGKQLSLKSNDISDKIGELALLLVSKGTYSTDGSNISI
DTYRLSGFLPEITQVNSYPFEKLWKFHKSNLCLMGAGTGNRSNDMIKPLVENHDYSII
DITYDSRLVKLRDPRNSALNVEISYEQYLKNFKQLYLNWNQEKLFKRSQVLHFRYDTS
RYNKFSIVADKPLFHLVNNSKVTETVWLLLESHLQDEGSQENRSVSFLNEAPECIICP
IEPPVECGGNHIGLQLVKLRLDAETERLLYCYSTTNNNFSIHSFSVVKEICFQRLKDT
KSLFAKVLFSFPYEIEGKASFDTCNFFQNPTFELEVHSEQDYQVLMDAACISTSSHDL
INIQVYYFNDYELIKPIMFDNHYQPGQGLKQDVPILTNVKYMIVCSTYGPPASTEFEL
LASIRLSSSWRLISGITLRSVNLIYGTYPYHCRNRFHWKETSDKLKIQMTLPTKKYST
NKLFIRVVPVESSARLRMRCNIFEPESALCVYECQEYRTCPSGGIVIPDLEVSRTNIV
VLMIERSVPISSCLPTEGQLDELELFVGSSQKIRIEKYSDDVIPK"
gene <568551..>570194
/locus_tag="YMR155W"
/db_xref="GeneID:855187"
mRNA <568551..>570194
/locus_tag="YMR155W"
/product="uncharacterized protein"
/transcript_id="NM_001182658.1"
/db_xref="GeneID:855187"
CDS 568551..570194
/locus_tag="YMR155W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/note="hypothetical protein; identified as interacting
with Hsp82p in a high-throughput two-hybrid screen"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013876.1"
/db_xref="GeneID:855187"
/db_xref="SGD:S000004764"
/translation="MVKKHQNSKMGNTNHFGHLKSFVGGNVVALGAGTPYLFSFYAPQ
LLSKCHIPVSASSKLSFSLTIGSSLMGILAGIVVDRSPKLSCLIGSMCVFIAYLILNL
CYKHEWSSTFLISLSLVLIGYGSVSGFYASVKCANTNFPQHRGTAGAFPVSLYGLSGM
VFSYLCSKLFGENIEHVFIFLMVACGCMILVGYFSLDIFSNAEGDDASIKEWELQKSR
ETDDNIVPLYENSNDYIGSPVRSSSPATYETYALSDNFQETSEFFALEDRQLSNRPLL
SPSSPHTKYDFEDENTSKNTVGENSAQKSMRLHVFQSLKSSTFIGYYIVLGILQGVGL
MYIYSVGFMVQAQVSTPPLNQLPINAEKIQSLQVTLLSLLSFCGRLSSGPISDFLVKK
FKAQRLWNIVIASLLVFLASNKISHDFSSIEDPSLRASKSFKNISVCSAIFGYSFGVL
FGTFPSIVADRFGTNGYSTLWGVLTTGGVFSVSVFTDILGRDFKANTGDDDGNCKKGV
LCYSYTFMVTKYCAAFNLLFVLGIIGYTYYRRRATANSL"
gene complement(<570300..>571016)
/gene="TPP1"
/locus_tag="YMR156C"
/db_xref="GeneID:855188"
mRNA complement(<570300..>571016)
/gene="TPP1"
/locus_tag="YMR156C"
/product="polynucleotide 3'-phosphatase"
/transcript_id="NM_001182659.1"
/db_xref="GeneID:855188"
CDS complement(570300..571016)
/gene="TPP1"
/locus_tag="YMR156C"
/EC_number="3.1.3.32"
/experiment="EXISTENCE:curator inference:GO:0005634
nucleus [PMID:11278831|PMID:15222769]"
/experiment="EXISTENCE:direct assay:GO:0003690
double-stranded DNA binding [PMID:15222769]"
/experiment="EXISTENCE:direct assay:GO:0046403
polynucleotide 3'-phosphatase activity [PMID:11278831]"
/experiment="EXISTENCE:genetic interaction:GO:0006302
double-strand break repair [PMID:11585902]"
/experiment="EXISTENCE:mutant phenotype:GO:0006302
double-strand break repair [PMID:11585902]"
/experiment="EXISTENCE:mutant phenotype:GO:0046403
polynucleotide 3'-phosphatase activity [PMID:15222769]"
/note="DNA 3'-phosphatase; functions in repair of
endogenous damage of double-stranded DNA, activity is
specific for removal of 3' phosphates at strand breaks;
similar to the l-2-haloacid dehalogenase superfamily;
homolog of human polynucleotide kinase/3'-phosphatase"
/codon_start=1
/product="polynucleotide 3'-phosphatase"
/protein_id="NP_013877.1"
/db_xref="GeneID:855188"
/db_xref="SGD:S000004765"
/translation="MSHKLTILPFLIKFTPKFPQSIDHDEHGLNVYAFDLDHTIIKPK
SPNISFSRSASDWQFINFNSKKSTLDYLCNIIDNDPTAVIVIFSNQGGVITVPRTSKS
CTKYTNKILLFLKAIKNDERGETLSHRLWLYAAPKRPKTFAANHSKITFASLGESYNN
DPNIFEKVRKPMTGMVEFFKRDLESAYRVSEQISPIKLNWIYYCGDAAGRKKDFSDSD
IKFAENLHVEFKYPEEIFHG"
gene complement(<571277..>572044)
/gene="AIM36"
/locus_tag="YMR157C"
/gene_synonym="FMP39"
/db_xref="GeneID:855189"
mRNA complement(<571277..>572044)
/gene="AIM36"
/locus_tag="YMR157C"
/gene_synonym="FMP39"
/product="Aim36p"
/transcript_id="NM_001182660.1"
/db_xref="GeneID:855189"
CDS complement(571277..572044)
/gene="AIM36"
/locus_tag="YMR157C"
/gene_synonym="FMP39"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]"
/note="hypothetical protein; null mutant displays reduced
respiratory growth and elevated frequency of mitochondrial
genome loss; the authentic, non-tagged protein is detected
in purified mitochondria in high-throughput studies"
/codon_start=1
/product="Aim36p"
/protein_id="NP_013878.1"
/db_xref="GeneID:855189"
/db_xref="SGD:S000004766"
/translation="MLRPLRKSVLASCRHCFKVCGGLPQKQLPLFSPLLLRARYSSTD
SSTKRSNKSDKIDAPGFKKIFLVAIIGTVIFVKTVQSLDKNKPKTTLSEEEFENVVKG
LKRRVAIFPQGEVDIKFSLSPSIEETRKVLQKSQGDDINELQFVDPVKVIDYYRTLRD
DRYEALLNEYYKKYGCDTYAYNLPTGMLVMLLGRYFKENFKTGDKLVVVNFPHSIADA
TRFENEVSIVSKIFVPRKLSGSDVCKYYETVGKADII"
gene <572248..>572715
/gene="MRPS8"
/locus_tag="YMR158W"
/gene_synonym="uS8m"
/db_xref="GeneID:855190"
mRNA <572248..>572715
/gene="MRPS8"
/locus_tag="YMR158W"
/gene_synonym="uS8m"
/product="mitochondrial 37S ribosomal protein MRPS8"
/transcript_id="NM_001182661.1"
/db_xref="GeneID:855190"
CDS 572248..572715
/gene="MRPS8"
/locus_tag="YMR158W"
/gene_synonym="uS8m"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:12392552]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:12392552]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005763
mitochondrial small ribosomal subunit [PMID:12392552]"
/note="Mitochondrial ribosomal protein of the small
subunit"
/codon_start=1
/product="mitochondrial 37S ribosomal protein MRPS8"
/protein_id="NP_013879.1"
/db_xref="GeneID:855190"
/db_xref="SGD:S000004767"
/translation="MSLVKLANTCAHLQNCSKVRVALTSIPYTKLQLQFAYNLYQQGF
LSSLQKGSTMGPDKDFVEVTPDNISTRRLWVGLKYRDNKPVLSSCKLISKPNSRIHLP
MEDMKKLCSGVTIRNIKPLQPGELILVRAHNNIMDINEAISKKLDGEVLCRVK"
gene complement(572883..572955)
/gene="EMT4"
/locus_tag="YNCM0028C"
/db_xref="GeneID:855191"
tRNA complement(572883..572955)
/gene="EMT4"
/locus_tag="YNCM0028C"
/product="tRNA-Met"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Methionine tRNA (tRNA-Met), functions in
translational elongation; not involved in translational
initiation; predicted by tRNAscan-SE analysis"
/db_xref="GeneID:855191"
/db_xref="SGD:S000006664"
repeat_region complement(573112..573338)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007116"
gene complement(<573194..>573331)
/locus_tag="YMR158C-A"
/gene_synonym="YMR158C-B"
/db_xref="GeneID:855192"
mRNA complement(<573194..>573331)
/locus_tag="YMR158C-A"
/gene_synonym="YMR158C-B"
/product="uncharacterized protein"
/transcript_id="NM_001184342.1"
/db_xref="GeneID:855192"
CDS complement(573194..573331)
/locus_tag="YMR158C-A"
/gene_synonym="YMR158C-B"
/experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
[PMID:36164978]"
/note="hypothetical protein; may contain a lipid
attachment site; localizes to cytosol, and to peroxisomes
in oleate-growing cells; YMR158C-A is not an essential
gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013880.1"
/db_xref="GeneID:855192"
/db_xref="SGD:S000007249"
/translation="MKMNYHLSTSSYTTSMLSCTVLDDDIRYEKLSWKLDEAEMQGLI
M"
gene complement(<574476..>574928)
/gene="ATG16"
/locus_tag="YMR159C"
/gene_synonym="APG15; APG16; CVT11; SAP18"
/db_xref="GeneID:855194"
mRNA complement(<574476..>574928)
/gene="ATG16"
/locus_tag="YMR159C"
/gene_synonym="APG15; APG16; CVT11; SAP18"
/product="Atg16p"
/transcript_id="NM_001182663.1"
/db_xref="GeneID:855194"
CDS complement(574476..574928)
/gene="ATG16"
/locus_tag="YMR159C"
/gene_synonym="APG15; APG16; CVT11; SAP18"
/experiment="EXISTENCE:direct assay:GO:0000407 phagophore
assembly site [PMID:11689437]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0016236
macroautophagy [PMID:11897782]"
/experiment="EXISTENCE:direct assay:GO:0034274
Atg12-Atg5-Atg16 complex [PMID:11897782]"
/experiment="EXISTENCE:direct assay:GO:0061908 phagophore
[PMID:23549786]"
/experiment="EXISTENCE:direct assay:GO:0120095
vacuole-isolation membrane contact site [PMID:23549786]"
/experiment="EXISTENCE:mutant phenotype:GO:0000422
autophagy of mitochondrion [PMID:19793921]"
/experiment="EXISTENCE:mutant phenotype:GO:0006501
C-terminal protein lipidation [PMID:17192262]"
/experiment="EXISTENCE:mutant phenotype:GO:0019776
Atg8-family ligase activity [PMID:17192262]"
/experiment="EXISTENCE:mutant phenotype:GO:0030674
protein-macromolecule adaptor activity [PMID:11897782]"
/experiment="EXISTENCE:mutant phenotype:GO:0032258
cytoplasm to vacuole transport by the Cvt pathway
[PMID:17192262]"
/experiment="EXISTENCE:mutant phenotype:GO:0034727
piecemeal microautophagy of the nucleus [PMID:18701704]"
/experiment="EXISTENCE:mutant phenotype:GO:0044805 late
nucleophagy [PMID:22768199]"
/experiment="EXISTENCE:mutant phenotype:GO:1905037
autophagosome organization [PMID:24485455]"
/experiment="EXISTENCE:physical interaction:GO:0034274
Atg12-Atg5-Atg16 complex [PMID:10406794]"
/note="Conserved protein involved in autophagy; interacts
with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p
multimers, which binds to membranes and localizes to the
pre-autophagosomal structure and are required for
autophagy; relocalizes from nucleus to cytoplasmic foci
upon DNA replication stress"
/codon_start=1
/product="Atg16p"
/protein_id="NP_013882.1"
/db_xref="GeneID:855194"
/db_xref="SGD:S000004769"
/translation="MGNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNE
LFQDNSGAIGGNIVSHDDALLNTLAILQKELKSKEQEIRRLKEVIALKNKNTERLNDE
LISGTIENNVLQQKLSDLKKEHSQLVARWLKKTEKETEAMNSEIDGTK"
gene <575066..>577516
/gene="CVM1"
/locus_tag="YMR160W"
/db_xref="GeneID:855195"
mRNA <575066..>577516
/gene="CVM1"
/locus_tag="YMR160W"
/product="Cvm1p"
/transcript_id="NM_001182664.1"
/db_xref="GeneID:855195"
CDS 575066..577516
/gene="CVM1"
/locus_tag="YMR160W"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal
membrane [PMID:35766971]"
/experiment="EXISTENCE:direct assay:GO:0098853 endoplasmic
reticulum-vacuole membrane contact site [PMID:35766971]"
/experiment="EXISTENCE:direct assay:GO:1990816
vacuole-mitochondrion membrane contact site
[PMID:35766971]"
/experiment="EXISTENCE:mutant phenotype:GO:0006665
sphingolipid metabolic process [PMID:35766971]"
/note="Protein involved in sphingolipid metabolism;
localizes to vacuolar contact sites with mitochondria, ER
and peroxisomes; mutant has enhanced sensitivity to
overexpression of mutant huntingtin; relative distribution
within the vacuolar membrane changes upon DNA replication
stress"
/codon_start=1
/product="Cvm1p"
/protein_id="NP_013883.1"
/db_xref="GeneID:855195"
/db_xref="SGD:S000004770"
/translation="MDVVQQKQDKQLQHQTQEQQQIREDQQEVPPQRPRQQNRWKPWW
NSTADDEPNTGRIAEYPNGQGRSSPTTDFQDSVNSNNDNKGIWSKIASFATSRYRSAP
IVVDDNTRYSQLNTEQINFLENEAKDIISKKSKSWCWYEAIPHISNSSNIIDSIDTPG
IISVSGTGSAKCPLPLNKYPGEGGNPGYNVFINDSLILPSDNPLNFLHVQPLRTKVLN
TIKNYYNFPNEQHLYLRQKKTALLKDKRIIIISVVGDLPEKYEQRSLESQRSAYYLSR
KLSQNLAQEQPQRVLTLSFQCPLHNQDLIPTYKECVELLNHWAHLFKEVDSIFFVGVY
HSVPLTLLLAKYIVQNNEVLEFDENTTVSVLSFQSCLQGYRFWDHSTDFTSNSYNNLG
SNSSTNENDSNDHDSNNDFTTKSQQIKEKQLFQGIDKKQQDTLSKIKNYRRIDSSESK
LVQDALDWLLFNWDTFRLTFFGKLYDNFMTISEKLAIDYNHPKILRNLWCNGKYMGID
LKNANNLNLDTDDEATSNINDVHVRTPNFESRLKIPTNRLFEITLWDILMITENLGYK
QFIPIINLLSPFFISRSFNDYTLPPNIRKQYQNSNKIWLQEMDSKWKMNGHQLNYDQR
EGESLGSSSESLLPENISTVKDFLQFVQYQNEKSSDFVRIYSDIYDDDKVYKCFLYNT
IFTKNPLSRKHLRLNIDLDTPTSILNTVNQYDLVWKIHDSFSKLIQLKNLPQREIPHA
LRLSISLNCFLDSTTSTSGPVFQRDTVEALRRLTEIWRTYQDWSPPTRGLKHLRDILS
VLAMYDNPKNLINDVRRT"
gene <577718..>578392
/gene="HLJ1"
/locus_tag="YMR161W"
/db_xref="GeneID:855196"
mRNA <577718..>578392
/gene="HLJ1"
/locus_tag="YMR161W"
/product="type I HSP40 co-chaperone HLJ1"
/transcript_id="NM_001182665.1"
/db_xref="GeneID:855196"
CDS 577718..578392
/gene="HLJ1"
/locus_tag="YMR161W"
/experiment="EXISTENCE:direct assay:GO:0001671 ATPase
activator activity [PMID:15342786]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:12514182]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway
[PMID:15252059|PMID:15342786]"
/note="Co-chaperone for Hsp40p; anchored in the ER
membrane; with its homolog Ydj1p promotes ER-associated
protein degradation (ERAD) of integral membrane
substrates; similar to E. coli DnaJ"
/codon_start=1
/product="type I HSP40 co-chaperone HLJ1"
/protein_id="NP_013884.1"
/db_xref="GeneID:855196"
/db_xref="SGD:S000004771"
/translation="MSFTEDQEKIALEILSKDKHEFYEILKVDRKATDSEIKKAYRKL
AIKLHPDKNSHPKAGEAFKVINRAFEVLSNEEKRSIYDRIGRDPDDRQMPSRGAASGF
RGSAGGSPMGGGFEDMFFNSRFGGQRAGPPEDIFDFLFNAGGSPFGASPFGPSASTFS
FGGPGGFRVYTNNRGGSPFMRQQPRSRQQQQQAEENAVNSQLKNMLVLFIIFIVLPMI
KDYLFS"
gene complement(<578951..>583921)
/gene="DNF3"
/locus_tag="YMR162C"
/db_xref="GeneID:855197"
mRNA complement(<578951..>583921)
/gene="DNF3"
/locus_tag="YMR162C"
/product="aminophospholipid-translocating P4-type ATPase
DNF3"
/transcript_id="NM_001182666.1"
/db_xref="GeneID:855197"
CDS complement(578951..583921)
/gene="DNF3"
/locus_tag="YMR162C"
/EC_number="7.6.2.1"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi
network [PMID:17093059]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:32661085]"
/experiment="EXISTENCE:direct assay:GO:0030140 trans-Golgi
network transport vesicle [PMID:12221123]"
/experiment="EXISTENCE:direct assay:GO:0070867 mating
projection tip membrane [PMID:25378585]"
/experiment="EXISTENCE:genetic interaction:GO:0090555
phosphatidylethanolamine flippase activity
[PMID:16452632]"
/experiment="EXISTENCE:genetic interaction:GO:0140345
phosphatidylcholine flippase activity [PMID:16452632]"
/experiment="EXISTENCE:genetic interaction:GO:0140346
phosphatidylserine flippase activity [PMID:16452632]"
/experiment="EXISTENCE:mutant phenotype:GO:0007124
pseudohyphal growth [PMID:32661085]"
/experiment="EXISTENCE:mutant phenotype:GO:0045332
phospholipid translocation [PMID:16452632|PMID:32661085]"
/experiment="EXISTENCE:mutant phenotype:GO:0090555
phosphatidylethanolamine flippase activity
[PMID:16452632]"
/experiment="EXISTENCE:mutant phenotype:GO:0140345
phosphatidylcholine flippase activity [PMID:16452632]"
/experiment="EXISTENCE:mutant phenotype:GO:0140346
phosphatidylserine flippase activity [PMID:32661085]"
/note="Trans-golgi network aminophospholipid translocase
(flippase); type 4 P-type ATPase; involved in phospholipid
translocation, contributing to the maintenance of membrane
lipid asymmetry in post-Golgi secretory vesicles; role in
protein trafficking between the Golgi and endosomal
system; localizes to the trans-Golgi network; localizes to
the shmoo tip where it has a redundant role in the
cellular response to mating pheromone"
/codon_start=1
/product="aminophospholipid-translocating P4-type ATPase
DNF3"
/protein_id="NP_013885.1"
/db_xref="GeneID:855197"
/db_xref="SGD:S000004772"
/translation="MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESK
TFSGSDNNDKDDRDETSGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSK
DGRHIPIILDHNAIEYKQAATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYA
QFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKE
ENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFL
DTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADLLLLTCDGENSECFV
ETMALDGETNLKSKQPHPELNKLTKAASGLANINAQVTVEDPNIDLYNFEGNLELKNH
RNDTIMKYPLGPDNVIYRGSILRNTQNVVGMVIFSGEETKIRMNALKNPRTKAPKLQR
KINMIIVFMVFVVATISLFSYLGHVLHKKKYIDQNKAWYLFQADAGVAPTIMSFIIMY
NTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHAETNTPCESRTATILEELGQVSYIFSD
KTGTLTDNKMIFRKFSLCGSSWLHNVDLGNSEDNFEDNRDNTNSLRLPPKAHNGSSID
VVSIGDQNVLDRLGFSDAPIEKGHRPSLDNFPKSRNSIEYKGNSSAIYTGRPSMRSLF
GKDNSHLSKQASVISPSETFSENIKSSFDLIQFIQRYPTALFSQKAKFFFLSLALCHS
CLPKKTHNESIGEDSIEYQSSSPDELALVTAARDLGYIVLNRNAQILTIKTFPDGFDG
EAKLENYEILNYIDFNSQRKRMSVLVRMPNQPNQVLLICKGADNVIMERLHDRELAAK
KMADICTSTKERKDAEAELVLQQRKSLERMVDEEAMARTSLRNSLSSVPRASLSLQAV
RKSLSMKNSRTRDPEKQIDSIDQFLETVKKSDQEIGSVVNKSRKSLHKQQIEKYGPRI
SIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIGSDELILNEEYVIERTLQAIDEFST
EGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDEAGAEIEDGLNLLGVTAI
EDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYSTVVILTTTDEN
IISKMNAVSQEVDSGNIAHCVVVIDGATMAMFEGNPTYMSVFVELCTKTDSVICCRAS
PSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGLQASRVSDYSI
GQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYEPWS
LSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFNWLIFMEWVILATT
NSLIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNWLAFTSV
VLSCGGWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFWCTSLVLALLPITLDIVY
KTFKVMIWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTDKVLS
RPRTNSRASAKTHNSSIYSMSNGNVDHSSKKNFFGNSSKKSSERYEVLPSGKLIKRPS
LKTQSSKDSIGGNITTKLTKKLKLPSRNVEDEDVNQIIQARLKDLE"
gene complement(<584271..>586388)
/gene="INP2"
/locus_tag="YMR163C"
/db_xref="GeneID:855198"
mRNA complement(<584271..>586388)
/gene="INP2"
/locus_tag="YMR163C"
/product="Inp2p"
/transcript_id="NM_001182667.1"
/db_xref="GeneID:855198"
CDS complement(584271..586388)
/gene="INP2"
/locus_tag="YMR163C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
[PMID:16678774]"
/experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal
membrane [PMID:16678774]"
/experiment="EXISTENCE:genetic interaction:GO:0045033
peroxisome inheritance [PMID:16678774]"
/experiment="EXISTENCE:mutant phenotype:GO:0043495
protein-membrane adaptor activity [PMID:16678774]"
/experiment="EXISTENCE:mutant phenotype:GO:0045033
peroxisome inheritance [PMID:16678774]"
/experiment="EXISTENCE:physical interaction:GO:0043495
protein-membrane adaptor activity [PMID:16678774]"
/experiment="EXISTENCE:physical interaction:GO:0045033
peroxisome inheritance [PMID:16678774]"
/note="Peroxisome-specific receptor important for
peroxisome inheritance; co-fractionates with peroxisome
membranes and co-localizes with peroxisomes in vivo;
physically interacts with the myosin V motor Myo2p; INP2
is not an essential gene"
/codon_start=1
/product="Inp2p"
/protein_id="NP_013886.1"
/db_xref="GeneID:855198"
/db_xref="SGD:S000004773"
/translation="MTTNSRPSALQAPGLQIFSMLKSSEEDGFMSSSLTLDSDNIIGV
TENNRQEFYSTWRKPSLLSSRSVLHEYSPTIVGSNDCTFSPITVGKTTKFFNWDDIIS
RIFMQQPFGVTHQFFEEFRYSIITSHFLNDMNHYRLSLHLDQSIMNFHKSSTLLKNVP
PKSVPFMATKYGKLAVAEDKKLYFRQNFNYLSMIITSYRVLTQLKKYCRKKNSPGLKR
VVILILVAVYLSIQQEYFRRHLICYKTLLKVRKVLESLQQVDVMIHKYHLRFKEIKNH
SFISRVSLISIADEHSSVIKELLVFSSDALFYKLKSIIPDIVIFSDTSELSKYCELYG
IDVPNLYYNNTTTVKDLDGKLYRLKLLKKFMLCCLLSLDMTGNENLSNVNMRNALNKI
FPDYMARVQLKKKYNPIGTFQNIVSLLRGLHSLLSTVLVSLNDHKQILYAFPEETSTN
TGCERANVCSFSKNDKLFQALNYLKMIENNLLAIDIRNGITENDRNIIEDKLEELITF
WKTSKICGNISRIQKVSPTNTINHGFHLDILKGRKSPRSSSVQGLSLERKVDFIDVAE
SVNDSFENDTELEEYEDYDCQEECSAGSRQNHRVDFIGKDSCRKPDFKQLSDNELRRK
LDERILKLAQENREGRERLRTAKSFELLRKAQASMSVKFGFQKPLRDDAFLESRPLSK
CKVSSEETIPFLYELKGLLGNDS"
gene complement(586636..586709)
/locus_tag="YNCM0029C"
/db_xref="GeneID:855199"
tRNA complement(586636..586709)
/locus_tag="YNCM0029C"
/product="tRNA-Val"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Valine tRNA (tRNA-Val), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:855199"
/db_xref="SGD:S000006765"
gene complement(<587274..>589550)
/gene="MSS11"
/locus_tag="YMR164C"
/db_xref="GeneID:855200"
mRNA complement(<587274..>589550)
/gene="MSS11"
/locus_tag="YMR164C"
/product="Mss11p"
/transcript_id="NM_001182668.1"
/db_xref="GeneID:855200"
CDS complement(587274..589550)
/gene="MSS11"
/locus_tag="YMR164C"
/experiment="EXISTENCE:curator inference:GO:0005634
nucleus [PMID:10515942]"
/experiment="EXISTENCE:direct assay:GO:0045944 positive
regulation of transcription by RNA polymerase II
[PMID:10515942|PMID:9987114]"
/experiment="EXISTENCE:genetic interaction:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:15466424]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:15466424|PMID:16568252|PMID:9342405|PMID:9987114]"
/note="Transcription factor; involved in regulation of
invasive growth and starch degradation; controls the
activation of FLO11 and STA2 in response to nutritional
signals; forms a heterodimer with Flo8p that interacts
with the Swi/Snf complex during transcriptional activation
of FLO1, FLO11, and STA1"
/codon_start=1
/product="Mss11p"
/protein_id="NP_013887.1"
/db_xref="GeneID:855200"
/db_xref="SGD:S000004774"
/translation="MDNTTNINTNERSSNTDFSSAPNIKGLNSHTQLQFDADSRVFVS
DVMAKNSKQLLYAHIYNYLIKNNYWNSAAKFLSEADLPLSRINGSASGGKTSLNASLK
QGLMDIASKGDIVSEDGLLPSKMLMDANDTFLLEWWEIFQSLFNGDLESGYQQDHNPL
RERIIPILPANSKSNMPSHFSNLPPNVIPPTQNSFPVSEESFRPNGDGSNFNLNDPTN
RNVSERFLSRTSGVYDKQNSANFAPDTAINSDIAGQQYATINLHKHFNDLQSPAQPQQ
SSQQQIQQPQHQPQHQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQTPYPI
VNPQMVPHIPSENSHSTGLMPSVPPTNQQFNAQTQSSMFSDQQRFFQYQLHHQNQGQA
PSFQQSQSGRFDDMNAMKMFFQQQALQQNSLQQNLGNQNYQSNTRNNTAEETTPTNDN
NANGNSLLQEHIRARFNKMKTIPQQMKNQSTVANPVVSDITSQQQYMHMMMQRMAANQ
QLQNSAFPPDTNRIAPANNTMPLQPGNMGSPVIENPGMRQTNPSGQNPMINMQPLYQN
VSSAMHAFAPQQQFHLPQHYKTNTSVPQNDSTSVFPLPNNNNNNNNNNNNNNNNNSNN
SNNNNNNNNNNNNSNNTPTVSQPSSKCTSSSSTTPNITTTIQPKRKQRVGKTKTKESR
KVAAAQKVMKSKKLEQNGDSAATNFINVTPKDSGGKGTVKVQNSNSQQQLNGSFSMDT
ETFDIFNIGDFSPDLMDS"
gene complement(<590040..>592628)
/gene="PAH1"
/locus_tag="YMR165C"
/gene_synonym="SMP2"
/db_xref="GeneID:855201"
mRNA complement(<590040..>592628)
/gene="PAH1"
/locus_tag="YMR165C"
/gene_synonym="SMP2"
/product="phosphatidate phosphatase PAH1"
/transcript_id="NM_001182669.1"
/db_xref="GeneID:855201"
CDS complement(590040..592628)
/gene="PAH1"
/locus_tag="YMR165C"
/gene_synonym="SMP2"
/EC_number="3.1.3.4"
/experiment="EXISTENCE:direct assay:GO:0000976
transcription cis-regulatory region binding
[PMID:15889145]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005773 vacuole
[PMID:22121197]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:26275961]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:16467296|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0008195
phosphatidate phosphatase activity
[PMID:16467296|PMID:35026226]"
/experiment="EXISTENCE:direct assay:GO:0031965 nuclear
membrane [PMID:35026226|PMID:20876142]"
/experiment="EXISTENCE:genetic interaction:GO:0019432
triglyceride biosynthetic process [PMID:24196957]"
/experiment="EXISTENCE:genetic interaction:GO:0034389
lipid droplet organization [PMID:21829381]"
/experiment="EXISTENCE:mutant phenotype:GO:0006276 plasmid
maintenance [PMID:8437575]"
/experiment="EXISTENCE:mutant phenotype:GO:0008195
phosphatidate phosphatase activity [PMID:16467296]"
/experiment="EXISTENCE:mutant phenotype:GO:0008654
phospholipid biosynthetic process
[PMID:16467296|PMID:17971454|PMID:35026226]"
/experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
respiration [PMID:8437575]"
/experiment="EXISTENCE:mutant phenotype:GO:0019432
triglyceride biosynthetic process
[PMID:24196957|PMID:35026226]"
/experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid
droplet organization [PMID:21422231]"
/experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole
fusion, non-autophagic [PMID:22121197]"
/note="Mg2+-dependent phosphatidate (PA) phosphatase;
dephosphorylates PA to yield diacylglycerol; regulates
phospholipid synthesis, nuclear/ER membrane growth, lipid
droplet formation, triacylglycerol synthesis, vacuolar
homeostasis and cell wall integrity; phosphorylated by
Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII,
regulating activity, localization, and proteosomal
degradation; homolog of mammalian lipins 1 and 2; human
homologs LPIN1, LPIN2, LPIN3 complement the null"
/codon_start=1
/product="phosphatidate phosphatase PAH1"
/protein_id="NP_013888.1"
/db_xref="GeneID:855201"
/db_xref="SGD:S000004775"
/translation="MQYVGRALGSVSKTWSSINPATLSGAIDVIVVEHPDGRLSCSPF
HVRFGKFQILKPSQKKVQVFINEKLSNMPMKLSDSGEAYFVFEMGDQVTDVPDELLVS
PVMSATSSPPQSPETSILEGGTEGEGEGENENKKKEKKVLEEPDFLDINDTGDSGSKN
SETTGSLSPTESSTTTPPDSVEERKLVEQRTKNFQQKLNKKLTEIHIPSKLDNNGDLL
LDTEGYKPNKNMMHDTDIQLKQLLKDEFGNDSDISSFIKEDKNGNIKIVNPYEHLTDL
SPPGTPPTMATSGSVLGLDAMESGSTLNSLSSSPSGSDTEDETSFSKEQSSKSEKTSK
KGTAGSGETEKRYIRTIRLTNDQLKCLNLTYGENDLKFSVDHGKAIVTSKLFVWRWDV
PIVISDIDGTITKSDALGHVLAMIGKDWTHLGVAKLFSEISRNGYNILYLTARSAGQA
DSTRSYLRSIEQNGSKLPNGPVILSPDRTMAALRREVILKKPEVFKIACLNDIRSLYF
EDSDNEVDTEEKSTPFFAGFGNRITDALSYRTVGIPSSRIFTINTEGEVHMELLELAG
YRSSYIHINELVDHFFPPVSLDSVDLRTNTSMVPGSPPNRTLDNFDSEITSGRKTLFR
GNQEEKFTDVNFWRDPLVDIDNLSDISNDDSDNIDEDTDVSQQSNISRNRANSVKTAK
VTKAPQRNVSGSTNNNEVLAASSDVENASDLVSSHSSSGSTPNKSTMSKGDIGKQIYL
ELGSPLASPKLRYLDDMDDEDSNYNRTKSRRASSAAATSIDKEFKKLSVSKAGAPTRI
VSKINVSNDVHSLGNSDTESRREQSVNETGRNQLPHNSMDDKDLDSRVSDEFDDDEFD
EDEFED"
gene complement(<593367..>594473)
/gene="MME1"
/locus_tag="YMR166C"
/db_xref="GeneID:855202"
mRNA complement(<593367..>594473)
/gene="MME1"
/locus_tag="YMR166C"
/product="Mme1p"
/transcript_id="NM_001182670.1"
/db_xref="GeneID:855202"
CDS complement(593367..594473)
/gene="MME1"
/locus_tag="YMR166C"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:25585246]"
/experiment="EXISTENCE:direct assay:GO:0015095 magnesium
ion transmembrane transporter activity [PMID:25585246]"
/experiment="EXISTENCE:direct assay:GO:0015693 magnesium
ion transport [PMID:25585246]"
/experiment="EXISTENCE:mutant phenotype:GO:1990616
magnesium ion export from mitochondrion [PMID:25585246]"
/note="Transporter of the mitochondrial inner membrane
that exports magnesium; involved in mitochondrial Mg2+
homeostasis; has similarity to human mitochondrial
ATP-Mg/Pi carriers"
/codon_start=1
/product="Mme1p"
/protein_id="NP_013889.1"
/db_xref="GeneID:855202"
/db_xref="SGD:S000004776"
/translation="MNSWNLSSSIPIIHTPHDHPPTSEGTPDQPNNNRKDDKLHKKRG
DSDEDLSPIWHCVVSGGIGGKIGDSAMHSLDTVKTRQQGAPNVKKYRNMISAYRTIWL
EEGVRRGLYGGYMAAMLGSFPSAAIFFGTYEYTKRTMIEDWQINDTITHLSAGFLGDF
ISSFVYVPSEVLKTRLQLQGRFNNPFFQSGYNYSNLRNAIKTVIKEEGFRSLFFGYKA
TLARDLPFSALQFAFYEKFRQLAFKIEQKDGRDGELSIPNEILTGACAGGLAGIITTP
MDVVKTRVQTQQPPSQSNKSYSVTHPHVTNGRPAALSNSISLSLRTVYQSEGVLGFFS
GVGPRFVWTSVQSSIMLLLYQMTLRGLSNAFPTD"
gene <594886..>597195
/gene="MLH1"
/locus_tag="YMR167W"
/gene_synonym="PMS2"
/db_xref="GeneID:855203"
mRNA <594886..>597195
/gene="MLH1"
/locus_tag="YMR167W"
/gene_synonym="PMS2"
/product="mismatch repair ATPase MLH1"
/transcript_id="NM_001182671.1"
/db_xref="GeneID:855203"
CDS 594886..597195
/gene="MLH1"
/locus_tag="YMR167W"
/gene_synonym="PMS2"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:11717305]"
/experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic
mismatch repair [PMID:16702432|PMID:23316435]"
/experiment="EXISTENCE:mutant phenotype:GO:0000713 meiotic
heteroduplex formation [PMID:15654114]"
/experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP
binding [PMID:10938116]"
/experiment="EXISTENCE:mutant phenotype:GO:0006298
mismatch repair [PMID:2685551]"
/experiment="EXISTENCE:mutant phenotype:GO:0007131
reciprocal meiotic recombination [PMID:10570173]"
/experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP
hydrolysis activity [PMID:11717305]"
/experiment="EXISTENCE:physical interaction:GO:0032389
MutLalpha complex
[PMID:11237696|PMID:8066446|PMID:10570173]"
/experiment="EXISTENCE:physical interaction:GO:0032390
MutLbeta complex [PMID:10570173]"
/experiment="EXISTENCE:physical interaction:GO:0097587
MutLgamma complex [PMID:9770499|PMID:10570173]"
/note="Protein required for mismatch repair in mitosis and
meiosis; also required for crossing over during meiosis;
forms a complex with Pms1p and Msh2p-Msh3p during mismatch
repair; required for silencing at the silent mating-type
loci and telomeres; human homolog is associated with
hereditary non-polyposis colon cancer"
/codon_start=1
/product="mismatch repair ATPase MLH1"
/protein_id="NP_013890.1"
/db_xref="GeneID:855203"
/db_xref="SGD:S000004777"
/translation="MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMI
DILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALA
SISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRL
RALRSHNDEYSKILDVVGRYAIHSKDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFN
KSVASNLITFHISKVEDLNLESVDGKVCNLNFISKKSISPIFFINNRLVTCDLLRRAL
NSVYSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLHAEL
SAIDTSRTFKASSISTNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQLRKA
KRQENKLVRIDASQAKITSFLSSSQQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTLN
ESEQPRDANTINDNDLKDQPKKKQKLGDYKVPSIADDEKNALPISKDGYIRVPKERVN
VNLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVC
YELFYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFDELNDDASKEKIISKIWDMS
SMLNEYYSIELVNDGLDNDLKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDE
QECLDGILREIALLYIPDMVPKVDTSDASLSEDEKAQFINRKEHISSLLEHVLFPCIK
RRFLAPRHILKDVVEIANLPDLYKVFERC"
gene complement(<597332..>599158)
/gene="CEP3"
/locus_tag="YMR168C"
/gene_synonym="CBF3; CSL1"
/db_xref="GeneID:855204"
mRNA complement(<597332..>599158)
/gene="CEP3"
/locus_tag="YMR168C"
/gene_synonym="CBF3; CSL1"
/product="Cep3p"
/transcript_id="NM_001182672.1"
/db_xref="GeneID:855204"
CDS complement(597332..599158)
/gene="CEP3"
/locus_tag="YMR168C"
/gene_synonym="CBF3; CSL1"
/experiment="EXISTENCE:direct assay:GO:0000776 kinetochore
[PMID:10352012]"
/experiment="EXISTENCE:direct assay:GO:0008301 DNA
binding, bending [PMID:10097110]"
/experiment="EXISTENCE:direct assay:GO:0019237 centromeric
DNA binding [PMID:10352012]"
/experiment="EXISTENCE:direct assay:GO:0031518 CBF3
complex [PMID:1997204|PMID:8670864|PMID:8706132]"
/experiment="EXISTENCE:mutant phenotype:GO:0000921 septin
ring assembly [PMID:16330709]"
/experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic
spindle assembly checkpoint signaling [PMID:11290706]"
/note="Essential kinetochore protein; component of the
CBF3 complex that binds the CDEIII region of the
centromere; contains an N-terminal Zn2Cys6 type zinc
finger domain, a C-terminal acidic domain, and a putative
coiled coil dimerization domain"
/codon_start=1
/product="Cep3p"
/protein_id="NP_013891.1"
/db_xref="GeneID:855204"
/db_xref="SGD:S000004778"
/translation="MFNRTTQLKSKHPCSVCTRRKVKCDRMIPCGNCRKRGQDSECMK
STKLITASSSKEYLPDLLLFWQNYEYWITNIGLYKTKQRDLTRTPANLDTDTEECMFW
MNYLQKDQSFQLMNFAMENLGALYFGSIGDISELYLRVEQYWDRRADKNHSVDGKYWD
ALIWSVFTMCIYYMPVEKLAEIFSVYPLHEYLGSNKRLNWEDGMQLVMCQNFARCSLF
QLKQCDFMAHPDIRLVQAYLILATTTFPYDEPLLANSLLTQCIHTFKNFHVDDFRPLL
NDDPVESIAKVTLGRIFYRLCGCDYLQSGPRKPIALHTEVSSLLQHAAYLQDLPNVDV
YREENSTEVLYWKIISLDRDLDQYLNKSSKPPLKTLDAIRRELDIFQYKVDSLEEDFR
SNNSRFQKFIALFQISTVSWKLFKMYLIYYDTADSLLKVIHYSKVIISLIVNNFHAKS
EFFNRHPMVMQTITRVVSFISFYQIFVESAAVKQLLVDLTELTANLPTIFGSKLDKLV
YLTERLSKLKLLWDKVQLLDSGDSFYHPVFKILQNDIKIIELKNDEMFSLIKGLGSLV
PLNKLRQESLLEEEDENNTEPSDFRTIVEEFQSEYNISDILS"
gene complement(<599352..>600872)
/gene="ALD3"
/locus_tag="YMR169C"
/db_xref="GeneID:855205"
mRNA complement(<599352..>600872)
/gene="ALD3"
/locus_tag="YMR169C"
/product="aldehyde dehydrogenase (NAD(+)) ALD3"
/transcript_id="NM_001182673.1"
/db_xref="GeneID:855205"
CDS complement(599352..600872)
/gene="ALD3"
/locus_tag="YMR169C"
/EC_number="1.2.1.3"
/experiment="EXISTENCE:direct assay:GO:0004029 aldehyde
dehydrogenase (NAD+) activity [PMID:10407263]"
/experiment="EXISTENCE:mutant phenotype:GO:0006598
polyamine catabolic process [PMID:12586697]"
/experiment="EXISTENCE:mutant phenotype:GO:0019483
beta-alanine biosynthetic process [PMID:12586697]"
/note="Cytoplasmic aldehyde dehydrogenase; involved in
beta-alanine synthesis; uses NAD+ as the preferred
coenzyme; very similar to Ald2p; expression is induced by
stress and repressed by glucose"
/codon_start=1
/product="aldehyde dehydrogenase (NAD(+)) ALD3"
/protein_id="NP_013892.1"
/db_xref="GeneID:855205"
/db_xref="SGD:S000004779"
/translation="MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPA
TGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLA
ALETLDAGKPFHSNAKQDLAQIIELTRYYAGAVDKFNMGETIPLTFNKFAYTLKVPFG
VVAQIVPWNYPLAMACRKMQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVV
NVIPGYGSVVGKALGTHMDIDKISFTGSTKVGGSVLEASGQSNLKDITLECGGKSPAL
VFEDADLDKAIEWVANGIFFNSGQICTANSRVYVQSSIYDKFVEKFKETAKKEWDVAG
KFDPFDEKCIVGPVISSTQYDRIKSYIERGKKEEKLDMFQTSEFPIGGAKGYFIPPTI
FTDVPETSKLLRDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFA
RDIKAGTVWINQTNQEEAKVPFGGFKMSGIGRESGDTGVDNYLQIKSVHVDLSLDK"
gene complement(<601562..>603082)
/gene="ALD2"
/locus_tag="YMR170C"
/db_xref="GeneID:855206"
mRNA complement(<601562..>603082)
/gene="ALD2"
/locus_tag="YMR170C"
/product="aldehyde dehydrogenase (NAD(+)) ALD2"
/transcript_id="NM_001182674.1"
/db_xref="GeneID:855206"
CDS complement(601562..603082)
/gene="ALD2"
/locus_tag="YMR170C"
/EC_number="1.2.1.3"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:mutant phenotype:GO:0004029
aldehyde dehydrogenase (NAD+) activity [PMID:12586697]"
/experiment="EXISTENCE:mutant phenotype:GO:0006598
polyamine catabolic process [PMID:12586697]"
/experiment="EXISTENCE:mutant phenotype:GO:0019483
beta-alanine biosynthetic process [PMID:12586697]"
/note="Cytoplasmic aldehyde dehydrogenase; involved in
ethanol oxidation and beta-alanine biosynthesis; uses NAD+
as the preferred coenzyme; expression is stress induced
and glucose repressed; very similar to Ald3p"
/codon_start=1
/product="aldehyde dehydrogenase (NAD(+)) ALD2"
/protein_id="NP_013893.1"
/db_xref="GeneID:855206"
/db_xref="SGD:S000004780"
/translation="MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPA
TGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLA
ALETLDAGKPYHSNAKGDLAQILQLTRYFAGSADKFDKGATIPLTFNKFAYTLKVPFG
VVAQIVPWNYPLAMACWKLQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVV
NIVPGYGSLVGQALASHMDIDKISFTGSTKVGGFVLEASGQSNLKDVTLECGGKSPAL
VFEDADLDKAIDWIAAGIFYNSGQNCTANSRVYVQSSIYDKFVEKFKETAKKEWDVAG
KFDPFDEKCIVGPVISSTQYDRIKSYIERGKREEKLDMFQTSEFPIGGAKGYFIPPTI
FTDVPQTSKLLQDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFA
RDIKAGTVWINSSNDEDVTVPFGGFKMSGIGRELGQSGVDTYLQTKAVHINLSLDN"
gene complement(<603868..>605520)
/gene="EAR1"
/locus_tag="YMR171C"
/db_xref="GeneID:855207"
mRNA complement(<603868..>605520)
/gene="EAR1"
/locus_tag="YMR171C"
/product="Ear1p"
/transcript_id="NM_001182675.1"
/db_xref="GeneID:855207"
CDS complement(603868..605520)
/gene="EAR1"
/locus_tag="YMR171C"
/experiment="EXISTENCE:direct assay:GO:0005768 endosome
[PMID:14562095|PMID:18367543]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0043328
protein transport to vacuole involved in
ubiquitin-dependent protein catabolic process via the
multivesicular body sorting pathway
[PMID:18367543|PMID:30361468]"
/experiment="EXISTENCE:mutant phenotype:GO:1990756
ubiquitin ligase-substrate adaptor activity
[PMID:30361468]"
/note="Specificity factor required for Rsp5p-dependent
ubiquitination; also required for sorting of specific
cargo proteins at the multivesicular body; mRNA is
targeted to the bud via the mRNA transport system
involving She2p"
/codon_start=1
/product="Ear1p"
/protein_id="NP_013894.1"
/db_xref="GeneID:855207"
/db_xref="SGD:S000004781"
/translation="MSFKFLIESLLLGSISGQIRCGRSSVIPRGDVSYGGDDTDELNM
DIMLFAFGTLIVVYIVICIVYFFTKQIATRLITAYYNEHGPGQRISLFSDYDENNAHV
HSRRLMENMSLRWPNNLDDADEVRDKLAQLSPEEQFYYKQGEEYIKQNPPFLLNQGLL
QQSEDSNPDTTREDPIMNEQTRQYIQEEGAYAWEFSPNPDMPNHTVIVENKTEVSFLN
YNYDASISTNLPIPCINKVYYCEFKIFETDGPLNSDENVSKGVISFGLSTQPYPYFRL
PGRHHHSIAYDSNGARRFNDSFKLNEQLRTLFPQCEKGDIVGIGYRSRSGTVFFTRNG
KKLNEKSVGGHIRGWKFQYLYPIIGSNVPCQIHVNFGTYGFVYIEANVKKWGYAKSNG
IKLPPPSYEDYGKDTLLESGGEDNDFDEDFSDGDSDNIAAGSTTNLNDDIIIRNGEIL
PPPPGFEFTMSPPTGKKIINEEINLDSLPMLPPSYSDDEHHSKNDKSAISGRIIGTSR
NLITDEASFDSVDNDNEDENDHERDPEQFSEFDDYESRMHGI"
gene <605981..>608140
/gene="HOT1"
/locus_tag="YMR172W"
/db_xref="GeneID:855208"
mRNA <605981..>608140
/gene="HOT1"
/locus_tag="YMR172W"
/product="Hot1p"
/transcript_id="NM_001182677.1"
/db_xref="GeneID:855208"
CDS 605981..608140
/gene="HOT1"
/locus_tag="YMR172W"
/experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding
transcription factor activity, RNA polymerase II-specific
[PMID:11336700]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10409737]"
/experiment="EXISTENCE:direct assay:GO:0016251 RNA
polymerase II general transcription initiation factor
activity [PMID:12743037]"
/experiment="EXISTENCE:direct assay:GO:0051123 RNA
polymerase II preinitiation complex assembly
[PMID:12743037]"
/experiment="EXISTENCE:genetic interaction:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:10722658|PMID:10409737]"
/experiment="EXISTENCE:mutant phenotype:GO:0016251 RNA
polymerase II general transcription initiation factor
activity [PMID:12743037]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:10409737|PMID:10722658|PMID:25904326]"
/experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
polymerase II preinitiation complex assembly
[PMID:12743037]"
/note="Transcription factor for glycerol biosynthetic
genes; required for the transient induction of glycerol
biosynthetic genes GPD1 and GPP2 in response to high
osmolarity; targets Hog1p to osmostress responsive
promoters; has similarity to Msn1p and Gcr1p"
/codon_start=1
/product="Hot1p"
/protein_id="NP_013895.1"
/db_xref="GeneID:855208"
/db_xref="SGD:S000004783"
/translation="MSGMGIAILCIVRTKIYRITISFDYSTLMSPFFLFLMMPTTLKD
GYRMNSQVNEDAIGINLDLSLPTHISPTTGSESASGSNASTLRNDGNALDGGLLRTSA
AISAPTGTSQPTETIGEKLSNEERVNSNVSASNSTTAGTGRMLSQSLTNDSPSNEIST
DQLKIFQRMDEMSARMIEMEESFNKLSNKIAEQNTMVLNLKQDNYKVMNKLNILLKLV
AQPSARPSTNNAQNKLAIELLNSISAVSSAYLQKMQNNGSGRQHTADLCTGDSNTHSG
INQHRTTNGTIDVNTNTAQLNNQFSNALNTILPDQQHNRNNVSQNINQSLPNRQLGPV
INTQANQNQSQVLIHNTNTHQQVNRSPISFPNASTDKPFKLNPNGIKRRRRNTQSNNN
ASTNDHASAAQKPISALSPLTNSHNSTTSMNYTNSSIHSGVTSASNSFHDLNSLNNFG
TTTALSLPSLALDNASFPPNQNVIPPIINNTQQPLSFSQLINQDSTTSELLPSGKSGV
NTNIVNRNRASTLPSYPKPMTVKSNVDDDGYQEDDDDDGDDEGDGRDNEEDSTAEEDE
VDDEIETDMKNASINKRRRSLHHKKSNSLNGRRKLHGESATKPNINSDLHYRILKAPT
DVKTIWEEYDTGIRGKPSIKHLEAKYGNKWRLNKNKKTFSRRKRLYKFILNGMERGKT
AQEMIETLENKRLYKDDEDGEVKKRTIGWLQESLAGI"
gene <608689..>609981
/gene="DDR48"
/locus_tag="YMR173W"
/db_xref="GeneID:855210"
mRNA <608689..>609981
/gene="DDR48"
/locus_tag="YMR173W"
/product="DNA damage-responsive protein 48"
/transcript_id="NM_001182678.1"
/db_xref="GeneID:855210"
CDS 608689..609981
/gene="DDR48"
/locus_tag="YMR173W"
/experiment="EXISTENCE:direct assay:GO:0003924 GTPase
activity [PMID:8444852]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0006281 DNA repair
[PMID:2111448]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:8444852]"
/experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
repair [PMID:2111448]"
/note="DNA damage-responsive protein; expression is
increased in response to heat-shock stress or treatments
that produce DNA lesions; contains multiple repeats of the
amino acid sequence NNNDSYGS; protein abundance increases
in response to DNA replication stress"
/codon_start=1
/product="DNA damage-responsive protein 48"
/protein_id="NP_013897.1"
/db_xref="GeneID:855210"
/db_xref="SGD:S000004784"
/translation="MGLFDKVKQFANSNNNNNDSGNNNQGDYVTKAENMIGEDRVNQF
KSKIGEDRFDKMESKVRQQFSNTSINDNDSNNNDSYGSNNNDSYGSNNNDSYGSNNND
SYGSNNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNNDSYGSNNN
DSYGSNNDDSYGSSNKNKSSYGSNNDDSYGSNNDDSYGSSNKKKSSYGSSNNDSYGSN
NDDSYGSNNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNDDSYGS
SNKNKSSYGSSSNDDSYGSSNNDDSYGSSNKKKSSYGSNNDDSYGSNNDDSYGSSNKK
KSSYGSSNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNDDSYGSS
NRNKNSYGSSNYGSSNNDDSYGSSNRGGRNQYGGDDDY"
gene complement(<610159..>610365)
/gene="PAI3"
/locus_tag="YMR174C"
/db_xref="GeneID:855212"
mRNA complement(<610159..>610365)
/gene="PAI3"
/locus_tag="YMR174C"
/product="Pai3p"
/transcript_id="NM_001182680.1"
/db_xref="GeneID:855212"
CDS complement(610159..610365)
/gene="PAI3"
/locus_tag="YMR174C"
/experiment="EXISTENCE:direct assay:GO:0004866
endopeptidase inhibitor activity [PMID:17145748]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0004866
endopeptidase inhibitor activity [PMID:2037077]"
/experiment="EXISTENCE:mutant phenotype:GO:0007039 protein
catabolic process in the vacuole [PMID:2037077]"
/note="Cytoplasmic proteinase A (Pep4p) inhibitor;
dependent on Pbs2p and Hog1p protein kinases for osmotic
induction; intrinsically unstructured, N-terminal half
becomes ordered in the active site of proteinase A upon
contact"
/codon_start=1
/product="Pai3p"
/protein_id="NP_013899.1"
/db_xref="GeneID:855212"
/db_xref="SGD:S000004786"
/translation="MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTD
ADESEKHNYQEQYNKLKGAGHKKE"
gene <611016..>611255
/gene="SIP18"
/locus_tag="YMR175W"
/db_xref="GeneID:855213"
mRNA <611016..>611255
/gene="SIP18"
/locus_tag="YMR175W"
/product="Sip18p"
/transcript_id="NM_001182681.1"
/db_xref="GeneID:855213"
CDS 611016..611255
/gene="SIP18"
/locus_tag="YMR175W"
/experiment="EXISTENCE:direct assay:GO:0005543
phospholipid binding [PMID:12082171]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22181064]"
/experiment="EXISTENCE:mutant phenotype:GO:0042631
cellular response to water deprivation [PMID:21420397]"
/note="Phospholipid-binding hydrophilin; essential to
overcome desiccation-rehydration process; expression is
induced by osmotic stress; SIP18 has a paralog, GRE1, that
arose from the whole genome duplication"
/codon_start=1
/product="Sip18p"
/protein_id="NP_013900.1"
/db_xref="GeneID:855213"
/db_xref="SGD:S000004787"
/translation="MSNMMNKFAEKLQGNDDSHQKGKNAKSSNKERDDMNMDMGMGHD
QSEGGMKMGHDQSGTKMNAGRGIANDWKTYENMKK"
rep_origin 611275..611489
/note="ARS1323; Autonomously Replicating Sequence"
/db_xref="SGD:S000118374"
gene <611314..>611508
/locus_tag="YMR175W-A"
/db_xref="GeneID:1466501"
mRNA <611314..>611508
/locus_tag="YMR175W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184660.1"
/db_xref="GeneID:1466501"
CDS 611314..611508
/locus_tag="YMR175W-A"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878143.1"
/db_xref="GeneID:1466501"
/db_xref="SGD:S000028848"
/translation="MNCLCLCSLYSKSISAYFSEFSSTNIYKSYLRLPSVLYYVCMMH
TMMPNQLDAVGIQSSESLLM"
gene <611740..>615975
/gene="ECM5"
/locus_tag="YMR176W"
/db_xref="GeneID:855214"
mRNA <611740..>615975
/gene="ECM5"
/locus_tag="YMR176W"
/product="Ecm5p"
/transcript_id="NM_001182682.1"
/db_xref="GeneID:855214"
CDS 611740..615975
/gene="ECM5"
/locus_tag="YMR176W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0070211 Snt2C
complex [PMID:19040720]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress [PMID:23878396]"
/note="Subunit of the Snt2C complex; physically associates
with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to
a small number of promoters; also colocalizes with Snt2p,
independently of Rpd3p, to promoters of stress response
genes in response to oxidative stress; contains
ATP/GTP-binding site motif A; null mutant exhibits
increased cellular volume, large drooping buds with
elongated necks; relative distribution to the nucleus
increases upon DNA replication stress"
/codon_start=1
/product="Ecm5p"
/protein_id="NP_013901.1"
/db_xref="GeneID:855214"
/db_xref="SGD:S000004788"
/translation="MSGHDSVTKISHILNEPVNEKVMVQNGFHESSKIADIELEIQER
PSIKQWESPRSAVIPTSNHNFSPFLYTQFKSRGAAPFAPETIKSVDLVELPEGVPARV
FHEKTGLFYQISPHSIPTFILAKKELPDPIKFYELVEDLGSVYGCVKLKIIPDADKFT
QLNVDVDRLWFKARKQFFNSNEFQRTKIVDFYAKLYNFHNKIKKSTLTRIPSIDKRTL
DLYRLRSCVKLRGGFNAVCEKKLWAQIGRELGYSGRIMSSLSTSLRSAYAKILLDFDI
YEEEEQAARNNEKNEDMVESEIFRHSNSRSRDEEEPLHKKAKIHRDVFRAGSINHEFK
RMRDIKHIKGFPTYFNSLTEFKLGYTQSTETTLPGYDFTFWENGMEIYDKSKYETKTS
PVYNLRQYYEKSLAVFTAIVAKFGSSYPDLFAKHTTLPQKEFERLYFHLLSEHFIDFE
IDTGLGLPCSMRSPGNNSSNEKFAIKNILDQWNLDNIPLNELSLLQHLDLDMANFTRT
TYDIGMLFSCQGWSVSDHFLPSIDFNHLGSTKLVYSIAPKDMEKFEALIARGKSEWDT
IQSRPRYSTSDDELKSFIETDFYKSFLDAEQSADYSNTGDNSKNSFPEDKIAGNTLHD
GSQSDFIFEPNFILANGIKLYKTTQEQGSYIFKFPKAFTCSIGSGFYLSQNAKFAPSS
WLRFSSEAAKWTSKMGFLPGLDVNQLLINALLNSNNPVLRKKCRDLISNYVVEEAENS
KKLGELIGTVDVVYNKLNYISDISLESTGLSKIVVTHGALQRNLSLKEFVVLLEKPEN
GAHSICGIPIRDQSGNLNVCLHSYFDSASLGIALDGLDKPPTSYLLVHNEDFEKKWDV
LMTSTFRNRTVPLNIIQYLISHTDSNTEFNRMLRSNFDDSLLLIEKCKKFIKTFVDVS
CSVKDVDFGNGFNLRHLPLKFSDNMADNLESLYESVRKCSIEFSEKPTIIRLYHVSRQ
FPIDNRDIIDGNNLDLLKELYQKSLTIPLKVSYWTKLTRKICRLEWLSVYEHIFIERC
DIKNEDPAKYSLPLLYSYFEFGLKYCDSEDIDKLGEVRKLILKYQDMMQKVRVFLKKD
PPSKISLSDLEDVLLDIEEYRLPIQSSFFSELDYVIREIENAKKMNDVNILYNTDNID
KIDELIRKNDPKFVKFANQFNGSRLDKRPLASDNSGSVKAKQELKVFKLWNQHLDQIM
QKNKFIEILPSIFRCLDLKSDKYIPLESCSKRQTKYCFCRRVEEGTAMVECEICKEWY
HVDCISNGELVPPDDPNVLFVCSICTPPCMAVDNIEGVTFELDDLKRILVESLKLSLI
PDPPILKNLFDVFAFALNFKNEMEKELFTNGYVNQLSSTHKIKYYLRKLKGSQCGFTN
LTDPLRKHCQVKDAEAIKWLTDNGRIIITGIPN"
gene <616566..>618098
/gene="MMT1"
/locus_tag="YMR177W"
/gene_synonym="MFT1"
/db_xref="GeneID:855215"
mRNA <616566..>618098
/gene="MMT1"
/locus_tag="YMR177W"
/gene_synonym="MFT1"
/product="Mmt1p"
/transcript_id="NM_001182683.1"
/db_xref="GeneID:855215"
CDS 616566..618098
/gene="MMT1"
/locus_tag="YMR177W"
/gene_synonym="MFT1"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14576278|PMID:16823961|PMID:24769239|PMID:9353309]"
/experiment="EXISTENCE:genetic interaction:GO:0006879
intracellular iron ion homeostasis [PMID:9353309]"
/experiment="EXISTENCE:mutant phenotype:GO:0006879
intracellular iron ion homeostasis [PMID:9353309]"
/note="Putative metal transporter involved in
mitochondrial iron accumulation; MMT1 has a paralog, MMT2,
that arose from the whole genome duplication"
/codon_start=1
/product="Mmt1p"
/protein_id="NP_013902.1"
/db_xref="GeneID:855215"
/db_xref="SGD:S000004789"
/translation="MLRICVKRPCIKIVLSQVRPALLVRKENLHISTGVKVEKSSIIN
QKDPNKVRVEINELKRQAEIEKAAIKELEKNPQYQKLAEAFNSHDHVHLRESETEQND
IISLGTIRDYKSSKCEQADKPSSLNLHSHTHSHGHTHSHAAHNPLLVLSTEQIRKNAG
VRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKP
TADYPYGYGKIETVGSLAVSTILAMAGISIGWSSLCALVGPVIPHTIIDTIGNLGHAH
TYSEDIIEDVTDINAAWIAAASIAAKEWIFRATRKIAINTNSNVLMANAWHHRVDSLT
SLVALVAISTGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDPRY
LEIETLVKDTLNKLISNNNSQKPYGLKELTLLSSGPNLRGHLTLEVPLQKWGNILGVN
EFEIVTHHLRNVLTNEVSNLRRLDIEYVEEKNGEENEHIKGQQNYKEDVLIKHDHTNT
HI"
gene <618479..>619303
/gene="FPY1"
/locus_tag="YMR178W"
/db_xref="GeneID:855216"
mRNA <618479..>619303
/gene="FPY1"
/locus_tag="YMR178W"
/product="Fpy1p"
/transcript_id="NM_001182684.1"
/db_xref="GeneID:855216"
CDS 618479..619303
/gene="FPY1"
/locus_tag="YMR178W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0047884 FAD
diphosphatase activity [PMID:29902190]"
/experiment="EXISTENCE:genetic interaction:GO:0042726
flavin-containing compound metabolic process
[PMID:29902190]"
/note="FAD pyrophosphatase; hydrolyzes FAD as the
preferred substrate but also acts on NADH and ADP-ribose
at lower rates; activity is dependent upon K+ and divalent
metal cations; green fluorescent protein (GFP)-fusion
protein localizes to both the cytoplasm and nucleus; FPY1
is not an essential gene; protein abundance increases in
response to DNA replication stress"
/codon_start=1
/product="Fpy1p"
/protein_id="NP_013903.1"
/db_xref="GeneID:855216"
/db_xref="SGD:S000004790"
/translation="MVKVTAACIIIGDEVLNGKVVDTNSTFFAKYCFDHGIQLKEIAT
IGDDETQIVDTVRRLVKNYDFIISTGGIGPTHDDITYECMAKSFNLPCELDEECKERM
RHKSDPEARLDADALKAHYQMATMPKGTNVKNYYVCDDLWVPICSISHKMYILPGIPQ
LFARMLKAFTPTLKKIYNLDKDPREYVRYFVRTHLTESQISKELKLIQDESTKVSEAI
KIGSYPHFGMGFNTVSILGEKKDDSYLKSIVNRVVNNLEGEVISSELENKFSNQES"
gene <619858..>622134
/gene="SPT21"
/locus_tag="YMR179W"
/db_xref="GeneID:855217"
mRNA <619858..>622134
/gene="SPT21"
/locus_tag="YMR179W"
/product="Spt21p"
/transcript_id="NM_001182685.1"
/db_xref="GeneID:855217"
CDS 619858..622134
/gene="SPT21"
/locus_tag="YMR179W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:genetic interaction:GO:0030466
silent mating-type cassette heterochromatin formation
[PMID:21057056]"
/experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA
heterochromatin formation [PMID:21057056]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:8035801]"
/experiment="EXISTENCE:mutant phenotype:GO:0031509
subtelomeric heterochromatin formation [PMID:21057056]"
/note="Protein with a role in transcriptional silencing;
required for normal transcription at several loci
including HTA2-HTB2 and HHF2-HHT2, but not required at the
other histone loci; binds with Spt10p to histone gene
promoters during S phase; localizes to nuclear foci that
become diffuse upon DNA replication stress"
/codon_start=1
/product="Spt21p"
/protein_id="NP_013904.1"
/db_xref="GeneID:855217"
/db_xref="SGD:S000004791"
/translation="MSELSQMTLKILYTLDNGSNGSYLARSRAPKQVRVANIPSPFPT
DSNEQTELRIGAIHLKTILHEIYLNSPEVLDHDTLKDGYDYNLYYRDICEVDEPLVSL
GLLSGLRKKFHKNSPYQYTENNIGEEESEERDEVTEEEYEDESFIVTGRVCSNVSALL
RRSYSNISNKKGRVVNNQIPEETLEVKLRFTKVITNLRTSGNNTTNSRISCLQMPSSL
PSATLPFTPKSQSLFKTNQIKNSRNARTTITINNTNSGTVGRRQTNPMPAPKAVRTQS
LPIWNLKPNIANTGFPRNSIAHKIYLADRKTEANQQNNQHQNIAYEINTLQNDNTIQR
TKIDDSVSKRFDFMLNKRKSTKKVSPGIATIAKKPASININPKQPPKTSGEKKANDKQ
TIVKVKNSNSKNSAKSTQAGCRRSSVIEHLNDHDDSILSDILSEPGIEGQKLQQKQKG
RKISLTSENDKENIPPQSITSKENKLEGDLDFNAEFPMSDFSDVVFKDEMGWFSNFNC
NFFESPTSASASQLNQQNLKPSITLNDPNTCNTIALENEDVSELETAQNNKISLPSDV
DKTSPIDSLSIPLIELTHSSSTTNMQRISIKEGSTLNITDSNNATPCDNDIKDRKASV
IDSDNTKPQAGLINFSTPADQPASDNNVTASKKLTSMLETQQSKRSHEEVLDEEEEEE
ALKKQKAIPSSPCGMFNYHQPMELSEDIVEEEQGHNIGDDNESDKTNDLFSTFIHSGI
RVSQVVTSPIGEFQSIKH"
gene complement(<622251..>623213)
/gene="CTL1"
/locus_tag="YMR180C"
/gene_synonym="CTH1"
/db_xref="GeneID:855218"
mRNA complement(<622251..>623213)
/gene="CTL1"
/locus_tag="YMR180C"
/gene_synonym="CTH1"
/product="polynucleotide 5'-phosphatase"
/transcript_id="NM_001182686.1"
/db_xref="GeneID:855218"
CDS complement(622251..623213)
/gene="CTL1"
/locus_tag="YMR180C"
/gene_synonym="CTH1"
/EC_number="3.6.1.74"
/experiment="EXISTENCE:direct assay:GO:0004651
polynucleotide 5'-phosphatase activity [PMID:10219091]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10219091]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10219091]"
/note="RNA 5'-triphosphatase, localizes to both the
nucleus and cytoplasm; CTL1 has a paralog, CET1, that
arose from the whole genome duplication"
/codon_start=1
/product="polynucleotide 5'-phosphatase"
/protein_id="NP_013905.1"
/db_xref="GeneID:855218"
/db_xref="SGD:S000004792"
/translation="MSDQPETPSNSRNSHENVGAKKADANVASKFRSLHISETTKPLT
STRALYKTTRNNSRGATEFHKHVCKLAWKYLACIDKSSISHIEIEMKFGVITDKRTHR
RMTPHNKPFIVQNRNGRLVSNVPEQMFSSFQELLRSKSENPSKCAPRVVKQVQKYTKD
SIYNCNNASKVGKLTSWRCSEDLRNKELKLTYIKKVRVKDFLIRYPQSSLDAKISISL
EVPEYETSAAFRNGFILQRTKSRSTYTFNDKMPLHLDLTKVTTTRRNSHQYTSHEVEV
EMDPIFKETISANDREKFNEYMCSFLNASDLIRKAAERDNMLTT"
gene complement(<623616..>624080)
/locus_tag="YMR181C"
/db_xref="GeneID:855219"
mRNA complement(<623616..>624080)
/locus_tag="YMR181C"
/product="uncharacterized protein"
/transcript_id="NM_001182687.1"
/db_xref="GeneID:855219"
CDS complement(623616..624080)
/locus_tag="YMR181C"
/note="hypothetical protein; mRNA transcribed as part of a
bicistronic transcript with a predicted transcriptional
repressor RGM1/YMR182C; mRNA is destroyed by
nonsense-mediated decay (NMD); not an essential gene;
YMR181C has a paralog, YPL229W, that arose from the whole
genome duplication"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013906.1"
/db_xref="GeneID:855219"
/db_xref="SGD:S000004793"
/translation="MTPLLQAEAKMNTSLYLTESIQQHEFNLTSPQSFYSSPSVPNSK
NNSGIFSYNTANNSRVSSSDEFTTQQDGMNTIMYKNNISKTFEDDIFYCPRSLLTPEE
QVVYQEIDKYYMEQALLTQLQISQTYSSTPKEEKIVKFNPYTSKSFSPASSE"
gene complement(<624532..>625167)
/gene="RGM1"
/locus_tag="YMR182C"
/db_xref="GeneID:855220"
mRNA complement(<624532..>625167)
/gene="RGM1"
/locus_tag="YMR182C"
/product="Rgm1p"
/transcript_id="NM_001182688.1"
/db_xref="GeneID:855220"
CDS complement(624532..625167)
/gene="RGM1"
/locus_tag="YMR182C"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:19372386|PMID:21206489]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:16880382|PMID:1923755]"
/note="Putative zinc finger DNA binding transcription
factor; contains two N-terminal C2H2 zinc fingers and
C-terminal proline rich domain; overproduction impairs
cell growth and induces expression of genes involved in
monosaccharide catabolism and aldehyde metabolism;
regulates expression of of Y' telomeric elements and
subtelomeric COS genes; relocalizes to the cytosol in
response to hypoxia; RGM1 has a paralog, USV1, that arose
from the whole genome duplication"
/codon_start=1
/product="Rgm1p"
/protein_id="NP_013907.1"
/db_xref="GeneID:855220"
/db_xref="SGD:S000004794"
/translation="MRGKQPKRNKDNASVKRNYRCVGYPDCNMSFNRTEHLARHIRKH
TGEKPFQCNICLKFFSRIDNLRQHQSSVHSDVDLMSLRRLQQSANSTANDPNATRMFP
QLRPYGIVVQPAPVPYNLPISTPASPQDTISLYAPPYFPHPMPSAPIPLPHQPPPLPI
YSYMQPLFLNHTPIQNHNIVELPPDSSDTPASPSKVQSFDQAKDASPNAKK"
gene <625811..>625897
/gene="MIN3"
/locus_tag="YMR182W-A"
/db_xref="GeneID:1466502"
mRNA <625811..>625897
/gene="MIN3"
/locus_tag="YMR182W-A"
/product="Min3p"
/transcript_id="NM_001184615.1"
/db_xref="GeneID:1466502"
CDS 625811..625897
/gene="MIN3"
/locus_tag="YMR182W-A"
/note="Mitochondrial hypothetical protein"
/codon_start=1
/product="Min3p"
/protein_id="NP_878144.1"
/db_xref="GeneID:1466502"
/db_xref="SGD:S000028693"
/translation="MRKPSAFHACNIIFLPLVKCASATIMLN"
gene 626349..626654
/gene="SNR83"
/locus_tag="YNCM0030W"
/db_xref="GeneID:9164955"
ncRNA 626349..626654
/ncRNA_class="snoRNA"
/gene="SNR83"
/locus_tag="YNCM0030W"
/product="SNR83"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:15306656]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:31804585]"
/experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA
pseudouridylation guide activity
[PMID:15306656|PMID:15923376]"
/experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA
pseudouridine synthesis [PMID:15306656|PMID:15923376]"
/experiment="EXISTENCE:physical interaction:GO:0031429 box
H/ACA snoRNP complex [PMID:15923376]"
/note="H/ACA box small nucleolar RNA (snoRNA); guides
pseudouridylation of small subunit (SSU) rRNA at positions
U1290 and U1415"
/transcript_id="NR_132245.1"
/db_xref="GeneID:9164955"
/db_xref="SGD:S000028468"
gene complement(<626921..>627808)
/gene="SSO2"
/locus_tag="YMR183C"
/db_xref="GeneID:855221"
mRNA complement(<626921..>627808)
/gene="SSO2"
/locus_tag="YMR183C"
/product="syntaxin"
/transcript_id="NM_001182689.1"
/db_xref="GeneID:855221"
CDS complement(626921..627808)
/gene="SSO2"
/locus_tag="YMR183C"
/experiment="EXISTENCE:direct assay:GO:0005628 prospore
membrane [PMID:19502581]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836|PMID:17507646|PMID:19502581]"
/experiment="EXISTENCE:direct assay:GO:0070300
phosphatidic acid binding [PMID:19502581]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0031321
ascospore-type prospore assembly [PMID:19502581]"
/experiment="EXISTENCE:physical interaction:GO:0005484
SNAP receptor activity [PMID:7954793]"
/note="Plasma membrane t-SNARE; involved in fusion of
secretory vesicles at the plasma membrane; syntaxin
homolog that is functionally redundant with Sso1p; SSO2
has a paralog, SSO1, that arose from the whole genome
duplication"
/codon_start=1
/product="syntaxin"
/protein_id="NP_013908.1"
/db_xref="GeneID:855221"
/db_xref="SGD:S000004795"
/translation="MSNANPYENNNPYAENYEMQEDLNNAPTGHSDGSDDFVAFMNKI
NSINANLSRYENIINQIDAQHKDLLTQVSEEQEMELRRSLDDYISQATDLQYQLKADI
KDAQRDGLHDSNKQAQAENCRQKFLKLIQDYRIIDSNYKEESKEQAKRQYTIIQPEAT
DEEVEAAINDVNGQQIFSQALLNANRRGEAKTALAEVQARHQELLKLEKTMAELTQLF
NDMEELVIEQQENVDVIDKNVEDAQQDVEQGVGHTNKAVKSARKARKNKIRCLIICFI
IFAIVVVVVVVPSVVETRK"
gene <628189..>628785
/gene="ADD37"
/locus_tag="YMR184W"
/db_xref="GeneID:855222"
mRNA <628189..>628785
/gene="ADD37"
/locus_tag="YMR184W"
/product="Add37p"
/transcript_id="NM_001182690.1"
/db_xref="GeneID:855222"
CDS 628189..628785
/gene="ADD37"
/locus_tag="YMR184W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:12711700]"
/note="hypothetical protein; involved in ER-associated
protein degradation; green fluorescent protein
(GFP)-fusion protein localizes to the cytoplasm and is
induced in response to the DNA-damaging agent MMS; YMR184W
is not an essential gene; protein abundance increases in
response to DNA replication stress"
/codon_start=1
/product="Add37p"
/protein_id="NP_013909.1"
/db_xref="GeneID:855222"
/db_xref="SGD:S000004796"
/translation="MAIKPTKSFQNCLEAEVPGYNDCPTVLFSIDPNSGPRSKSKQRT
KSKRCVSGRLATEVLDLYGNTKTATTPPPVLRRPSVTAAQQESACEGVLVKDQGDRQL
QPILCSKEELVAKINDLCVCGSKLSSKELEFYKKKLDSNITKILQNEHTKTVLSQIFN
EKDKNMAVKTIKHWMVTDTTISNWCPAFLKIFENAMPN"
gene <629025..>631970
/gene="RTP1"
/locus_tag="YMR185W"
/db_xref="GeneID:855223"
mRNA <629025..>631970
/gene="RTP1"
/locus_tag="YMR185W"
/product="Rtp1p"
/transcript_id="NM_001182691.1"
/db_xref="GeneID:855223"
CDS 629025..631970
/gene="RTP1"
/locus_tag="YMR185W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:23438601]"
/experiment="EXISTENCE:mutant phenotype:GO:0006606 protein
import into nucleus [PMID:23438601]"
/note="Protein required for the nuclear import and
biogenesis of RNA pol II; conflicting evidence on whether
null mutant is viable with elongated buds, or inviable;
interacts with Rpb2, Rpb3, Nup116p, Nup100p and components
of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to
human TMCO7 gene"
/codon_start=1
/product="Rtp1p"
/protein_id="NP_013910.1"
/db_xref="GeneID:855223"
/db_xref="SGD:S000004797"
/translation="MNEDKEQKINIHDILNTRPKLTKKTALDVFFEDLDDNVITPINE
YVLDSGSSSSSSIYQALKCSNNNEFVAVLLQKFQNLHIHVLEQQRRLIESKSDLLPIS
LHDMKYVDELINLLIIHGIDANLSPTMKIPFDSKRINTFKKGQKSAEYETPRWHTINN
DTLSQVITVFYNVLTSERSSDYLREIISKGSAYANILLGLIVLHLQLPNRYSSQMITN
LEDTQETYTLFGVYTLLVETIQDEKVREPILSKLTTLTLRRPENGLISLIDFVLGVRD
AEDIDIEKFNRIYQILMSKPKTMTNLQYLTELFKQIYDGLTFVNRPILVTCLNGLILK
FYLRNKRIVNDFLFKKVRSIIFNSPLTDHTAKELNDVINVLISLSKNSSSDLLNDLVT
SCPDEDGTTPGQFFLYVWIYALFLKKNQKLDPLEINKLSISDNKSTDSIHFPEQSSSK
YYEVVLSLLKSLIVITENFQYLNVLSLNLLNFEHEKWKYLIDLDTQLPYISVKNTDMA
ELFFEKGSKNSQISEFLQDMDLSIELFMEFLVLLNDEEQSKTLFLDILKRWVHHTKKS
EKRSSDNHSGMPSVTDNALILMDLKLLECMNNRFKTKIVNKPKDVLIVIDQLIDVVQE
KDETIQEVEADSDDEVEEGEETEELDPNENSSYKIILQLLSTVLSESSSSILLQNSYI
LKSISRKLQSFNTNASEIDALLASIDNILINGHTTERNDNIEIEMDEERLDKAITSLH
DPLVPIKSYGLTELRHLAEKKSPVISLEKVLQIHLDYLKNMDPFIYLNVIKGLTTLCE
LEPETILPLLAEFYANKKKKNRLDDVLKVGEVFINYIQRQNELFQGKLAYLIIDTCLS
IVRPNDSKPLDNRWRMSSMSILGMCLQINARGVSDRIRDMLDCVFGILQLEQPQNHLK
DKDDSFLMRRSAVHLIHDLLYSTGFDLLPFEYNYDKLKTLLSYVRDQDEDYMVCEQID
KLLTVLDSL"
gene <632355..>634472
/gene="HSC82"
/locus_tag="YMR186W"
/gene_synonym="HSP90"
/db_xref="GeneID:855224"
mRNA <632355..>634472
/gene="HSC82"
/locus_tag="YMR186W"
/gene_synonym="HSP90"
/product="Hsp90 family chaperone HSC82"
/transcript_id="NM_001182692.1"
/db_xref="GeneID:855224"
CDS 632355..634472
/gene="HSC82"
/locus_tag="YMR186W"
/gene_synonym="HSP90"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:18492664]"
/experiment="EXISTENCE:direct assay:GO:0051082 unfolded
protein binding [PMID:9465043]"
/experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D
snoRNP assembly [PMID:18268103]"
/experiment="EXISTENCE:mutant phenotype:GO:0000723
telomere maintenance [PMID:17954556]"
/experiment="EXISTENCE:mutant phenotype:GO:0006457 protein
folding [PMID:7791797]"
/experiment="EXISTENCE:mutant phenotype:GO:0034605
cellular response to heat [PMID:2674684]"
/experiment="EXISTENCE:mutant phenotype:GO:0043248
proteasome assembly [PMID:12853471]"
/note="Cytoplasmic chaperone of the Hsp90 family; plays a
role in determining prion variants; redundant in function
and nearly identical with Hsp82p, and together they are
essential; expressed constitutively at 10-fold higher
basal levels than HSP82 and induced 2-3 fold by heat
shock; contains two acid-rich unstructured regions that
promote the solubility of chaperone-substrate complexes;
HSC82 has a paralog, HSP82, that arose from the whole
genome duplication"
/codon_start=1
/product="Hsp90 family chaperone HSC82"
/protein_id="NP_013911.1"
/db_xref="GeneID:855224"
/db_xref="SGD:S000004798"
/translation="MAGETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDK
IRYQALSDPKQLETEPDLFIRITPKPEEKVLEIRDSGIGMTKAELINNLGTIAKSGTK
AFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNEDEQYIWESNAGGSFTVTL
DEVNERIGRGTVLRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLLVTKEVEKEVP
IPEEEKKDEEKKDEDDKKPKLEEVDEEEEEKKPKTKKVKEEVQELEELNKTKPLWTRN
PSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKK
NNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNI
VKKLIEAFNEIAEDSEQFDKFYSAFAKNIKLGVHEDTQNRAALAKLLRYNSTKSVDEL
TSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQ
LKEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKDILGDQVEKVVVSYK
LLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKR
VDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLISLGLNIDEDEETET
APEASTEAPVEEVPADTEMEEVD"
rep_origin 634501..634588
/note="ARS1324; Autonomously Replicating Sequence"
/db_xref="SGD:S000118375"
gene complement(<634689..>635984)
/locus_tag="YMR187C"
/db_xref="GeneID:855225"
mRNA complement(<634689..>635984)
/locus_tag="YMR187C"
/product="uncharacterized protein"
/transcript_id="NM_001182693.1"
/db_xref="GeneID:855225"
CDS complement(634689..635984)
/locus_tag="YMR187C"
/note="hypothetical protein; YMR187C is not an essential
gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013912.1"
/db_xref="GeneID:855225"
/db_xref="SGD:S000004799"
/translation="MTPPHFFLSLIKKRCICWICLEESTYDSTWLQHTCGCNLQIHKR
CYIRWLYQMHVELFLPNTVDLPKDADLPIITCLKCLVDGHHDFMTTFSLTEIWETRPI
WGQKSVPFQNDYVFNLMSLYTKRDNHPPYVLVKFGECPQCKKTNFIKRPTVTIQSSVL
SLFYQWQKITRYVIPLGITSLFLLNPEKTSFDIGLWQLRCLFPENVLRNMLNISTTKA
LDVYAQTERGLLSIPLTSSIIIYGFIHYLSNISNVSANAILFKWVYLSIVKTAGNKYY
KGIGLPKIILYSNLATFCYNFTFKRLVDLIYRRLINKGGKYLYHGNFENSSNSVPAEE
FFIRRNWYAILAEKILWPFVGKCTGGLLLNAFLWIQRKFKIEWTPNCSPSEFRMIFNI
IGCGTAAIGWSSLKLYASYKRCQELEKINEFIEQSCKGE"
gene complement(<636291..>637004)
/gene="MRPS17"
/locus_tag="YMR188C"
/gene_synonym="uS17m"
/db_xref="GeneID:855226"
mRNA complement(<636291..>637004)
/gene="MRPS17"
/locus_tag="YMR188C"
/gene_synonym="uS17m"
/product="mitochondrial 37S ribosomal protein MRPS17"
/transcript_id="NM_001182694.1"
/db_xref="GeneID:855226"
CDS complement(636291..637004)
/gene="MRPS17"
/locus_tag="YMR188C"
/gene_synonym="uS17m"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:12392552]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:12392552]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24390141|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005763
mitochondrial small ribosomal subunit [PMID:12392552]"
/note="Mitochondrial ribosomal protein of the small
subunit"
/codon_start=1
/product="mitochondrial 37S ribosomal protein MRPS17"
/protein_id="NP_013913.1"
/db_xref="GeneID:855226"
/db_xref="SGD:S000004800"
/translation="MARQNFLGLVVSQGKMQKTVKVRVETKVFNKKINKELFHRRDYL
VHDEGEISREGDLVRIEATRPLSKRKFFAIAEIIRNKGQQFALYESEAQLSVAKEEAQ
KAKEFLDKRSVRENKLNEKTTLLRDIRTIQDALSSGSTPKELLEIKQRYGIQDFSQET
VRQLLQLDISGLEVNLEKQRSLIDRIQTRLSELLSNDLKCDQFLKDHGVEDPLTLKKN
IKKNLLRKHVMMDMQQPSQ"
gene <637500..>640604
/gene="GCV2"
/locus_tag="YMR189W"
/gene_synonym="GSD2"
/db_xref="GeneID:855227"
mRNA <637500..>640604
/gene="GCV2"
/locus_tag="YMR189W"
/gene_synonym="GSD2"
/product="glycine decarboxylase subunit P"
/transcript_id="NM_001182695.1"
/db_xref="GeneID:855227"
CDS 637500..640604
/gene="GCV2"
/locus_tag="YMR189W"
/gene_synonym="GSD2"
/EC_number="1.4.4.2"
/experiment="EXISTENCE:direct assay:GO:0004375 glycine
dehydrogenase (decarboxylating) activity
[PMID:320197|PMID:8830251]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:genetic interaction:GO:0006730
one-carbon metabolic process [PMID:10871621]"
/experiment="EXISTENCE:mutant phenotype:GO:0019464 glycine
decarboxylation via glycine cleavage system
[PMID:8830251]"
/note="P subunit of the mitochondrial glycine
decarboxylase complex; glycine decarboxylase is required
for the catabolism of glycine to 5,10-methylene-THF;
expression is regulated by levels of 5,10-methylene-THF in
the cytoplasm"
/codon_start=1
/product="glycine decarboxylase subunit P"
/protein_id="NP_013914.1"
/db_xref="GeneID:855227"
/db_xref="SGD:S000004801"
/translation="MLRTRVTALLCRATVRSSTNYVSLARTRSFHSQSILLKTAATDI
TSTQYSRIFNPDLKNIDRPLDTFARRHLGPSPSDVKKMLKTMGYSDLNAFIEELVPPN
ILKRRPLKLEAPSKGFCEQEMLQHLEKIANKNHYKVKNFIGKGYYGTILPPVIQRNLL
ESPEWYTSYTPYQPEISQGRLEALLNFQTVVSDLTGLPVANASLLDEGTAAGEAMLLS
FNISRKKKLKYVIDKKLHQQTKSVLHTRAKPFNIEIIEVDCSDIKKAVDVLKNPDVSG
CLVQYPATDGSILPPDSMKQLSDALHSHKSLLSVASDLMALTLLKPPAHYGADIVLGS
SQRFGVPMGYGGPHAAFFAVIDKLNRKIPGRIVGISKDRLGKTALRLALQTREQHIKR
DKATSNICTAQALLANVASSYCVYHGPKGLQNISRRIFSLTSILANAIENDSCPHELI
NKTWFDTLTIKLGNGISSEQLLDKALKEFNINLFAVDTTTISLALDETTTKADVENLL
KVFDIENSSQFLSEDYSNSFPREFQRTDEILRNEVFHMHHSETAMLRYLHRLQSRDLS
LANSMIPLGSCTMKLNSTVEMMPITWPQFSNIHPFQPSNQVQGYKELITSLEKDLCSI
TGFDGISLQPNSGAQGEYTGLRVIRSYLESKGENHRNVCLIPVSAHGTNPASAAMAGL
KVVPVNCLQDGSLDLVDLKNKAEQHSKELAAVMITYPSTYGLFEPGIQHAIDIVHSFG
GQVYLDGANMNAQVGLTSPGDLGADVCHLNLHKTFSIPHGGGGPAGAPICVKSHLIPH
LPKHDVVDMITGIGGSKSIDSVSSAPYGNALVLPISYAYIKMMGNEGLPFSSVIAMLN
SNYMMTRLKDHYKILFVNEMSTLKHCAHEFIVDLREYKAKGVEAIDVAKRLQDYGFHA
PTLAFPVPGTLMIEPTESENLEELDRFCDAMISIKEEINALVAGQPKGQILKNAPHSL
EDLITSSNWDTRGYTREEAAYPLPFLRYNKFWPTVARLDDTYGDMNLICTCPSVEEIA
NETE"
gene complement(<640915..>645258)
/gene="SGS1"
/locus_tag="YMR190C"
/db_xref="GeneID:855228"
mRNA complement(<640915..>645258)
/gene="SGS1"
/locus_tag="YMR190C"
/product="ATP-dependent DNA helicase SGS1"
/transcript_id="NM_001182696.1"
/db_xref="GeneID:855228"
CDS complement(640915..645258)
/gene="SGS1"
/locus_tag="YMR190C"
/EC_number="3.6.4.12"
/experiment="EXISTENCE:direct assay:GO:0003678 DNA
helicase activity [PMID:9545297]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:9271578]"
/experiment="EXISTENCE:direct assay:GO:0006265 DNA
topological change [PMID:22885009]"
/experiment="EXISTENCE:direct assay:GO:0006268 DNA
unwinding involved in DNA replication [PMID:10366502]"
/experiment="EXISTENCE:direct assay:GO:0031422 RecQ family
helicase-topoisomerase III complex
[PMID:15899853|PMID:25588990]"
/experiment="EXISTENCE:direct assay:GO:0032508 DNA duplex
unwinding [PMID:18440969]"
/experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA
helicase activity [PMID:9545297]"
/experiment="EXISTENCE:direct assay:GO:0044806
G-quadruplex DNA unwinding [PMID:10198430]"
/experiment="EXISTENCE:genetic interaction:GO:0000706
meiotic DNA double-strand break processing
[PMID:20150422]"
/experiment="EXISTENCE:genetic interaction:GO:0000722
telomere maintenance via recombination
[PMID:17550308|PMID:16546998]"
/experiment="EXISTENCE:genetic interaction:GO:0000723
telomere maintenance [PMID:19595717]"
/experiment="EXISTENCE:genetic interaction:GO:0000724
double-strand break repair via homologous recombination
[PMID:19158388]"
/experiment="EXISTENCE:genetic interaction:GO:0000729 DNA
double-strand break processing [PMID:18806779]"
/experiment="EXISTENCE:genetic interaction:GO:0007534 gene
conversion at mating-type locus [PMID:18806779]"
/experiment="EXISTENCE:genetic interaction:GO:0010520
regulation of reciprocal meiotic recombination
[PMID:18691965]"
/experiment="EXISTENCE:genetic interaction:GO:0010947
negative regulation of meiotic joint molecule formation
[PMID:18691964]"
/experiment="EXISTENCE:genetic interaction:GO:0031573
mitotic intra-S DNA damage checkpoint signaling
[PMID:19158388]"
/experiment="EXISTENCE:genetic interaction:GO:0031860
telomeric 3' overhang formation
[PMID:19595717|PMID:20808892]"
/experiment="EXISTENCE:genetic interaction:GO:0044818
mitotic G2/M transition checkpoint [PMID:18805091]"
/experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic
sister chromatid segregation [PMID:7736577]"
/experiment="EXISTENCE:mutant phenotype:GO:0000722
telomere maintenance via recombination
[PMID:15994923|PMID:17550308]"
/experiment="EXISTENCE:mutant phenotype:GO:0000724
double-strand break repair via homologous recombination
[PMID:19158388]"
/experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA
double-strand break processing [PMID:18805091]"
/experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic
intra-S DNA damage checkpoint signaling [PMID:19158388]"
/experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic
chromosome segregation [PMID:7736577]"
/experiment="EXISTENCE:mutant phenotype:GO:0051276
chromosome organization [PMID:11138010]"
/experiment="EXISTENCE:physical interaction:GO:0031422
RecQ family helicase-topoisomerase III complex
[PMID:15889139]"
/note="RecQ family nucleolar DNA helicase; role in genome
integrity maintenance, chromosome synapsis, meiotic joint
molecule/crossover formation; stimulates activity of
Top3p; rapidly lost in response to rapamycin in
Rrd1p-dependent manner; forms nuclear foci upon DNA
replication stress; yeast SGS1 complements mutations in
human homolog BLM implicated in Bloom syndrome; also
similar to human WRN implicated in Werner syndrome; human
BLM and WRN can each complement yeast null mutant"
/codon_start=1
/product="ATP-dependent DNA helicase SGS1"
/protein_id="NP_013915.1"
/db_xref="GeneID:855228"
/db_xref="SGD:S000004802"
/translation="MVTKPSHNLRREHKWLKETATLQEDKDFVFQAIQKHIANKRPKT
NSPPTTPSKDECGPGTTNFITSIPASGPTNTATKQHEVMQTLSNDTEWLSYTATSNQY
ADVPMVDIPASTSVVSNPRTPNGSKTHNFNTFRPHMASSLVENDSSRNLGSRNNNKSV
IDNSSIGKQLENDIKLEVIRLQGSLIMALKEQSKLLLQKCSIIESTSLSEDAKRLQLS
RDIRPQLSNMSIRIDSLEKEIIKAKKDGMSKDQSKGRSQVSSQDDNIISSILPSPLEY
NTSSRNSNLTSTTATTVTKALAITGAKQNITNNTGKNSNNDSNNDDLIQVLDDEDDID
CDPPVILKEGAPHSPAFPHLHMTSEEQDELTRRRNMRSREPVNYRIPDRDDPFDYVMG
KSLRDDYPDVEREEDELTMEAEDDAHSSYMTTRDEEKEENELLNQSDFDFVVNDDLDP
TQDTDYHDNMDVSANIQESSQEGDTRSTITLSQNKNVQVILSSPTAQSVPSNGQNQIG
VEHIDLLEDDLEKDAILDDSMSFSFGRQHMPMSHSDLELIDSEKENEDFEEDNNNNGI
EYLSDSDLERFDEERENRTQVADIQELDNDLKIITERKLTGDNEHPPPSWSPKIKREK
SSVSQKDEEDDFDDDFSLSDIVSKSNLSSKTNGPTYPWSDEVLYRLHEVFKLPGFRPN
QLEAVNATLQGKDVFVLMPTGGGKSLCYQLPAVVKSGKTHGTTIVISPLISLMQDQVE
HLLNKNIKASMFSSRGTAEQRRQTFNLFINGLLDLVYISPEMISASEQCKRAISRLYA
DGKLARIVVDEAHCVSNWGHDFRPDYKELKFFKREYPDIPMIALTATASEQVRMDIIH
NLELKEPVFLKQSFNRTNLYYEVNKKTKNTIFEICDAVKSRFKNQTGIIYCHSKKSCE
QTSAQMQRNGIKCAYYHAGMEPDERLSVQKAWQADEIQVICATVAFGMGIDKPDVRFV
YHFTVPRTLEGYYQETGRAGRDGNYSYCITYFSFRDIRTMQTMIQKDKNLDRENKEKH
LNKLQQVMAYCDNVTDCRRKLVLSYFNEDFDSKLCHKNCDNCRNSANVINEERDVTEP
AKKIVKLVESIQNERVTIIYCQDVFKGSRSSKIVQANHDTLEEHGIGKSMQKSEIERI
FFHLITIRVLQEYSIMNNSGFASSYVKVGPNAKKLLTGKMEIKMQFTISAPNSRPSTS
SSFQANEDNIPVIAQKSTTIGGNVAANPPRFISAKEHLRSYTYGGSTMGSSHPITLKN
TSDLRSTQELNNLRMTYERLRELSLNLGNRMVPPVGNFMPDSILKKMAAILPMNDSAF
ATLGTVEDKYRRRFKYFKATIADLSKKRSSEDHEKYDTILNDEFVNRAAASSNGIAQS
TGTKSKFFGANLNEAKENEQIINQIRQSQLPKNTTSSKSGTRSISKSSKKSANGRRGF
RNYRGHYRGRK"
gene <645656..>646777
/gene="SPG5"
/locus_tag="YMR191W"
/db_xref="GeneID:855229"
mRNA <645656..>646777
/gene="SPG5"
/locus_tag="YMR191W"
/product="Spg5p"
/transcript_id="NM_001182697.1"
/db_xref="GeneID:855229"
CDS 645656..646777
/gene="SPG5"
/locus_tag="YMR191W"
/experiment="EXISTENCE:direct assay:GO:0070628 proteasome
binding [PMID:22904326]"
/experiment="EXISTENCE:mutant phenotype:GO:0043248
proteasome assembly [PMID:22904326]"
/note="Protein required for proteasome assembly during
quiescence; binds to base of the proteasome regulartory
particle; required for survival at high temperature during
stationary phase; not required for growth on
nonfermentable carbon sources"
/codon_start=1
/product="Spg5p"
/protein_id="NP_013916.2"
/db_xref="GeneID:855229"
/db_xref="SGD:S000004803"
/translation="MAVGGNNWSMWLRMSRVHLRQITKSLDRTLISLSHGNFSHQYNR
NIFVTWWKSLFEASTAFRRASGLTVSPLTRRGIARFDHFRPVPNVSKFASFPRVPKGA
PRGLFTNWNMTTSKRLLGQRAYSTSSIKFTQEAVNNMTISLRCFFNSLGGLNQCSHSN
SCKAYQNASNVTSKQDHVQPVALKKLSQKDINFIRNLELFKIMKTQNEVVDETSAYYM
EKPGSYIEFTISEFNVNGTFSAPLSFLDPSLLADLDEMIRNYKYELKSIYSSVDMILQ
NYGSLPITFHRNKIRIHFPNSTVVETEKLIAGLNIATGVIYADTSPDISLEGTNLNAL
VNVDNSGSVWSFVKEPSFPSRSAFSPILSDASYDTYELV"
gene <647118..>649280
/gene="GYL1"
/locus_tag="YMR192W"
/gene_synonym="APP2"
/db_xref="GeneID:855230"
mRNA <647118..>649280
/gene="GYL1"
/locus_tag="YMR192W"
/gene_synonym="APP2"
/product="Gyl1p"
/transcript_id="NM_001182698.1"
/db_xref="GeneID:855230"
CDS 647118..649280
/gene="GYL1"
/locus_tag="YMR192W"
/gene_synonym="APP2"
/experiment="EXISTENCE:direct assay:GO:0000131 incipient
cellular bud site [PMID:15331637]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005798
Golgi-associated vesicle [PMID:15331637]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:15331637]"
/experiment="EXISTENCE:direct assay:GO:0005933 cellular
bud [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005934 cellular
bud tip [PMID:15331637|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:14562095|PMID:15331637]"
/experiment="EXISTENCE:genetic interaction:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:15802519]"
/experiment="EXISTENCE:genetic interaction:GO:0017157
regulation of exocytosis [PMID:15331637]"
/experiment="EXISTENCE:physical interaction:GO:0005515
protein binding
[PMID:10992286|PMID:12857883|PMID:15802519]"
/experiment="EXISTENCE:physical interaction:GO:0017157
regulation of exocytosis [PMID:15331637]"
/note="Putative GTPase activating protein (GAP) with a
role in exocytosis; stimulates Gyp5p GAP activity on
Ypt1p, colocalizes with Gyp5p at sites of polarized
growth; interacts with Gyp5p, Rvs161p, and Rvs167p;
involved in recruiting Rvs167p to the bud tip during
polarized growth; increases in abundance and relocalizes
from bud neck to cytoplasm upon DNA replication stress;
GYL1 has a paralog, GYP5, that arose from the whole genome
duplication"
/codon_start=1
/product="Gyl1p"
/protein_id="NP_013917.1"
/db_xref="GeneID:855230"
/db_xref="SGD:S000004804"
/translation="MNSNEDIHEERIEVPRTPHQTQPEKDSDRIALRDEISVPEGDEK
AYSDEKVEMATTNASSNFGSNESAKDGESIGAFSNPHEALMQSKLREESQSKTILPSD
DLSQQLETEESKVEEALKRITSPPLPPRADCIEESASALKSSLPPVLAGNKNDQAPLD
RPQLPPRQVVNAETLHLKAPHGNATPSKSPTSAVGNSSSSTPPTLPPRRIEDPLDLAA
QKHFLASTFKRNMLFYKSEDNSIKCDLDKNILNLKEDSKKINNNEIPEEVSSFWLKVI
GDYQNILINDIETLHFQLSRGIPAAYRLVVWQLVSYAKSKSFDPIYETYLTEMAPFDV
QEFENQLKMMDEVPSEYVKRISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANA
FGLLVRLMKVYGLRLLFLPSASEIDILCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLP
GFFTTLFQKKLPTEIQPRIGDMVFLEGIDSIMRILATLLSNSRDHLLKMGFDDMLELL
KSGLLDAYIKQNDGTRGDTLLSNECMDKLLQDSMMKVAITPKTMKKYSSEYEEIHRLD
NEKEVQYKSITEKNLHLQKHVRKLENDYTSLNREHVTIANELVKNRLNIESVLNENNG
YKLQILDLKKKLDSEKKKQVLGVYVPNDLKKDLEETMKKNTQVMDENLKLQDRISELE
RLIEEIKTANKNGTLFEYSNSKNNPLGAGWSGFKKVFK"
rep_origin 649309..649552
/note="ARS1325; Autonomously Replicating Sequence"
/db_xref="SGD:S000118376"
gene <650036..>650812
/gene="MRPL24"
/locus_tag="YMR193W"
/gene_synonym="bL28m"
/db_xref="GeneID:855231"
mRNA <650036..>650812
/gene="MRPL24"
/locus_tag="YMR193W"
/gene_synonym="bL28m"
/product="mitochondrial 54S ribosomal protein YmL24/YmL14"
/transcript_id="NM_001182700.1"
/db_xref="GeneID:855231"
CDS 650036..650812
/gene="MRPL24"
/locus_tag="YMR193W"
/gene_synonym="bL28m"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:9151978]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:9151978]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005762
mitochondrial large ribosomal subunit [PMID:9151978]"
/note="Mitochondrial ribosomal protein of the large
subunit; two mitochondrial ribosomal proteins, YmL14 and
YmL24, have been assigned to the same gene"
/codon_start=1
/product="mitochondrial 54S ribosomal protein YmL24/YmL14"
/protein_id="NP_013918.1"
/db_xref="GeneID:855231"
/db_xref="SGD:S000004806"
/translation="MQKIFRPFQLTRGFTSSVKNFRQWRLIETRKIAKQPNYQVGDAK
PLHMPKERKKFPDYKYGESNIFKQSNKGLYGGSFVQFGNNISESKAKTRKKWLPNVVK
KGLWSETLNRKISIKMTAKVLKTISKEGGIDNYLTKEKSARIKELGPTGWKLRYRVLK
RKDEIENPPHKDAPIIEMAGGKKAKIYYDEIVNGSPRKISVGRRRLMSFLYPLEKLEY
RSVGKDLNYKKFVELFADVPVKDILARLEDHKFDLSTITV"
gene <651145..>651910
/gene="RPL36A"
/locus_tag="YMR194W"
/gene_synonym="RPL39B"
/db_xref="GeneID:855232"
mRNA join(<651145..651160,651624..>651910)
/gene="RPL36A"
/locus_tag="YMR194W"
/gene_synonym="RPL39B"
/product="ribosomal 60S subunit protein L36A"
/transcript_id="NM_001182701.1"
/db_xref="GeneID:855232"
CDS join(651145..651160,651624..651910)
/gene="RPL36A"
/locus_tag="YMR194W"
/gene_synonym="RPL39B"
/experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic
translation [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
[PMID:6337137]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:18782943]"
/note="Ribosomal 60S subunit protein L36A; N-terminally
acetylated; binds to 5.8 S rRNA; homologous to mammalian
ribosomal protein L36, no bacterial homolog; RPL36A has a
paralog, RPL36B, that arose from the whole genome
duplication"
/codon_start=1
/product="ribosomal 60S subunit protein L36A"
/protein_id="NP_013920.1"
/db_xref="GeneID:855232"
/db_xref="SGD:S000004807"
/translation="MTVKTGIAIGLNKGKKVTSMTPAPKISYKKGAASNRTKFVRSLV
REIAGLSPYERRLIDLIRNSGEKRARKVAKKRLGSFTRAKAKVEEMNNIIAASRRH"
gene 652275..652532
/gene="SNR11"
/locus_tag="YNCM0031W"
/db_xref="GeneID:9164951"
ncRNA 652275..652532
/ncRNA_class="snoRNA"
/gene="SNR11"
/locus_tag="YNCM0031W"
/product="SNR11"
/experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA
pseudouridylation guide activity [PMID:15923376]"
/experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA
pseudouridine synthesis [PMID:15923376]"
/experiment="EXISTENCE:physical interaction:GO:0005730
nucleolus [PMID:2121740]"
/experiment="EXISTENCE:physical interaction:GO:0031429 box
H/ACA snoRNP complex [PMID:15923376|PMID:9472021]"
/note="H/ACA box small nucleolar RNA (snoRNA); guides
pseudouridylation of large subunit (LSU) rRNA at position
U2416"
/transcript_id="NR_132246.1"
/db_xref="GeneID:9164951"
/db_xref="SGD:S000007293"
gene complement(<652594..>652887)
/gene="CMC4"
/locus_tag="YMR194C-B"
/db_xref="GeneID:1466503"
mRNA complement(join(<652594..652775,652848..>652887))
/gene="CMC4"
/locus_tag="YMR194C-B"
/product="Cmc4p"
/transcript_id="NM_001184524.1"
/db_xref="GeneID:1466503"
CDS complement(join(652594..652775,652848..652887))
/gene="CMC4"
/locus_tag="YMR194C-B"
/experiment="EXISTENCE:direct assay:GO:0005758
mitochondrial intermembrane space [PMID:19703468]"
/note="Protein that localizes to the mitochondrial
intermembrane space; localizes via the Mia40p-Erv1p
system; contains twin cysteine-x(9)-cysteine motifs"
/codon_start=1
/product="Cmc4p"
/protein_id="NP_878145.1"
/db_xref="GeneID:1466503"
/db_xref="SGD:S000028514"
/translation="MSNPCQKEACAIQDCLLSHQYDDAKCAKVIDQLYICCSKFYNDN
GKDSRSPCCPLPSLLELKMKQRKLTPGDS"
gene <654034..>654417
/gene="ICY1"
/locus_tag="YMR195W"
/db_xref="GeneID:855235"
mRNA <654034..>654417
/gene="ICY1"
/locus_tag="YMR195W"
/product="Icy1p"
/transcript_id="NM_001182702.1"
/db_xref="GeneID:855235"
CDS 654034..654417
/gene="ICY1"
/locus_tag="YMR195W"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:14562095]"
/note="hypothetical protein; required for viability in
rich media of cells lacking mitochondrial DNA; mutants
have an invasive growth defect with elongated morphology;
induced by amino acid starvation; ICY1 has a paralog,
ATG41, that arose from the whole genome duplication"
/codon_start=1
/product="Icy1p"
/protein_id="NP_013922.1"
/db_xref="GeneID:855235"
/db_xref="SGD:S000004808"
/translation="MSSNYATPLDDEVFPLSFANYQFTEHVSLGEHYSLNTSEDAKYN
NLNGPFVVPRDTGKFDLNTSSASDETVFSLDNPQENNYKHQAMNNVQDCRMAVAAKTT
QSCDKLTDLYANAAQQNYRLWLSSF"
gene <655076..>658342
/locus_tag="YMR196W"
/db_xref="GeneID:855236"
mRNA <655076..>658342
/locus_tag="YMR196W"
/product="uncharacterized protein"
/transcript_id="NM_001182703.1"
/db_xref="GeneID:855236"
CDS 655076..658342
/locus_tag="YMR196W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:24390141]"
/note="hypothetical protein; green fluorescent protein
(GFP)-fusion protein localizes to the cytoplasm; YMR196W
is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013923.1"
/db_xref="GeneID:855236"
/db_xref="SGD:S000004809"
/translation="MNKLRDKFVDSTVEEERLRENRNHEKYWYRWGPYLSERSWATVR
EDYSLNGDAWSNFPFEHANARVFRWGEDGLFGVSDNKQLVCMNVALWNGKDERLKERL
FGLTGPQGNHGEDVKELYFYLDNTPTHSYMKALYKYPFKKAFPYKELVQKNGERGYED
KEFEVYDIDGLYRDSETGDNPYFDVFFEMAKDDENPSELNFRLTIHNRSKIDSGELYI
APQLFFRNTWAFDGTRTKDKPLLERDAEAANLINMTHKKYGNCQMVFQPSPGGFSSGT
NEEEEDKEVEDIDPLLLFTDNESNLVKLFNEEKNPSEYTKDAFEEYLVQGKTDAVNPE
NKGTKACAVYHFKNIPPGEYVTVRYKFTNDPKNSIFKAQNLAVVDEDEFDLIFDNREE
EADNFYWRITPLPISDELRNLQRQAFSGLLWTKQFYNFTYDAWYNGDANVKPRPPPNR
ANGRNKNWKHLYIEDILSMPDKWEYPFFASWDTAFHCIPLAMIDPEFAKRQLDLLTRE
WYMHPNGQIPAYEWNFNDVNPPVHAWAVYRVFKIERNMYNREDRTFLERVFQKLLLNF
TWWVNRKDTEGKNVFEGGFLGLDNIGVFNRSEPLPTGGTLEQADSTGWMAFFSLQMLN
IALELAKENPVYEDIASKFFEHFILISDSMSFEYATDITGEKCKEVIKQNLWNEADKF
YYDAISWGDHKVQLPIRSLVGLIPLYASMTLEPSIIKQFRGFKKRVDWFVNNRPEIFD
RNIASMSKKGVGERLLLSLVTKERLTAILSRLLDETEFLSPYGIRSLSKYHEKHPFEM
NVNGVEYMVKYLPGESDSGMFGGNSNWRGPIWFPTSFLIMEALQRFYLYYGSDFKVEC
PVGSGDYLNLAEVAEELGYRMIHLFVPDENGERAIHYGDHSKFLSSDPYFRDYVPFFE
YFDGDTGRGLGASHQCGWTALVAKWISDVGISCVRLPRTPRSSVATTASTESSEQGPK
MKRMARRKSAKSLVNYTATILDLTEEEKRHHRIGGTHSGLTPQSSISSDKARHLMEEM
NEEEGIHETVVPEDRHNFETKLIGKLKDKVKNMKVTDKAKDEDIDPMDPMSPLNKDVS
"
gene complement(<658545..>659198)
/gene="VTI1"
/locus_tag="YMR197C"
/db_xref="GeneID:855237"
mRNA complement(<658545..>659198)
/gene="VTI1"
/locus_tag="YMR197C"
/product="v-SNARE protein VTI1"
/transcript_id="NM_001182704.1"
/db_xref="GeneID:855237"
CDS complement(658545..659198)
/gene="VTI1"
/locus_tag="YMR197C"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:9398683]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005484 SNAP
receptor activity [PMID:19805279]"
/experiment="EXISTENCE:direct assay:GO:0006906 vesicle
fusion [PMID:11739407]"
/experiment="EXISTENCE:mutant phenotype:GO:0006891
intra-Golgi vesicle-mediated transport [PMID:9398683]"
/experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi
to vacuole transport [PMID:9199167]"
/experiment="EXISTENCE:mutant phenotype:GO:0016236
macroautophagy [PMID:11694599]"
/experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole
fusion, non-autophagic [PMID:10385523]"
/experiment="EXISTENCE:physical interaction:GO:0031201
SNARE complex [PMID:10397773]"
/note="Protein involved in cis-Golgi membrane traffic;
v-SNARE that interacts with two t-SNARES, Sed5p and
Pep12p; required for multiple vacuolar sorting pathways;
human homolog VTI1A can complement yeast null mutant"
/codon_start=1
/product="v-SNARE protein VTI1"
/protein_id="NP_013924.1"
/db_xref="GeneID:855237"
/db_xref="SGD:S000004810"
/translation="MSSLLISYESDFKTTLEQAKASLAEAPSQPLSQRNTTLKHVEQQ
QDELFDLLDQMDVEVNNSIGDASERATYKAKLREWKKTIQSDIKRPLQSLVDSGDRDR
LFGDLNASNIDDDQRQQLLSNHAILQKSGDRLKDASRIANETEGIGSQIMMDLRSQRE
TLENARQTLFQADSYVDKSIKTLKTMTRRLVANKFISYAIIAVLILLILLVLFSKFK"
gene <659745..>661529
/gene="CIK1"
/locus_tag="YMR198W"
/db_xref="GeneID:855238"
mRNA <659745..>661529
/gene="CIK1"
/locus_tag="YMR198W"
/product="Cik1p"
/transcript_id="NM_001182705.1"
/db_xref="GeneID:855238"
CDS 659745..661529
/gene="CIK1"
/locus_tag="YMR198W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005816 spindle
pole body [PMID:11729143|PMID:1644287]"
/experiment="EXISTENCE:direct assay:GO:0005819 spindle
[PMID:11729143]"
/experiment="EXISTENCE:direct assay:GO:0005871 kinesin
complex [PMID:10087265]"
/experiment="EXISTENCE:direct assay:GO:0008569
minus-end-directed microtubule motor activity
[PMID:16107877]"
/experiment="EXISTENCE:direct assay:GO:0051321 meiotic
cell cycle [PMID:11729143]"
/experiment="EXISTENCE:mutant phenotype:GO:0000742
karyogamy involved in conjugation with cellular fusion
[PMID:1644287]"
/experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear
migration involved in conjugation with cellular fusion
[PMID:19386762]"
/experiment="EXISTENCE:mutant phenotype:GO:0003777
microtubule motor activity [PMID:10087265]"
/experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic
cell cycle [PMID:11729143]"
/experiment="EXISTENCE:mutant phenotype:GO:0060236
regulation of mitotic spindle organization
[PMID:25313961]"
/note="Kinesin-associated protein; required for both
karyogamy and mitotic spindle organization, interacts
stably and specifically with Kar3p and may function to
target this kinesin to a specific cellular role; locus
encodes a long and short transcript with differing
functions; CIK1 has a paralog, VIK1, that arose from the
whole genome duplication"
/codon_start=1
/product="Cik1p"
/protein_id="NP_013925.1"
/db_xref="GeneID:855238"
/db_xref="SGD:S000004811"
/translation="MNNSKIPKLSFHSDPNNVTRDFPKTKRQKVQKREMDMILTPNNN
KLNILHSSGSGIRRCYTDDTSATYTKKLTFGGDPKIIERVKNNERKVRKDIDSLLNAI
SEIEKESVRIHARELPAITLELDAKVKACRELQNEIDGLSTEMDLKDNQCDLQRKNVE
LSSKNIVSMHAVKVQEFENDLEEELSNAKREWTYKLMEVENLKPDERLTDEMRQLKTE
FEEVNRKLFILQNENENECKNYKKELDKKFEIFKKVKNDARIELDGEQERLSKVLKDL
QDTHGELKENIKTCRDEFNDFEKRIGEAEVNFHSMELAVVPLKKKLASTSQALTQVQE
EKKQVEGEANNWKKKYVNELEKVQQELYTRQNLATSIEEIKGYTRCFAYANERQMPDE
FHINYVDRCICENSGEKRVQVFDRVVLEEIHKDHKRLYNECIPFLEKYISKLINCSII
VVSQQPTAPMKKTLLKQLIEQYGENYKMTLNILHLDGSIKHSDVGLDNPTEIRDLSQD
EECMNILTLDTKLGKDEESHSMNIYIGSMSTVQLNRELDDAPSVLSHILTKTKQCFVF
KINAGENIEKALALAGKLKRTITLPQLD"
gene <662644..>664284
/gene="CLN1"
/locus_tag="YMR199W"
/db_xref="GeneID:855239"
mRNA <662644..>664284
/gene="CLN1"
/locus_tag="YMR199W"
/product="cyclin CLN1"
/transcript_id="NM_001182706.1"
/db_xref="GeneID:855239"
CDS 662644..664284
/gene="CLN1"
/locus_tag="YMR199W"
/experiment="EXISTENCE:direct assay:GO:0001932 regulation
of protein phosphorylation [PMID:10409718|PMID:8387915]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11080155]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11080155]"
/experiment="EXISTENCE:direct assay:GO:0016538
cyclin-dependent protein serine/threonine kinase regulator
activity [PMID:10409718|PMID:8387915]"
/experiment="EXISTENCE:genetic interaction:GO:0007089
traversing start control point of mitotic cell cycle
[PMID:2147225|PMID:2574633]"
/note="G1 cyclin involved in regulation of the cell cycle;
activates Cdc28p kinase to promote the G1 to S phase
transition; late G1 specific expression depends on
transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF
(Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from
the whole genome duplication; cell cycle arrest phenotype
of the cln1 cln2 cln3 triple null mutant is complemented
by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or
CCNE1"
/codon_start=1
/product="cyclin CLN1"
/protein_id="NP_013926.1"
/db_xref="GeneID:855239"
/db_xref="SGD:S000004812"
/translation="MNHSEVKTGLIVTAKQTYYPIELSNAELLTHYETIQEYHEEISQ
NVLVQSSKTKPDIKLIDQQPEMNPHQTREAIVTFLYQLSVMTRVSNGIFFHAVRFYDR
YCSKRVVLKDQAKLVVGTCLWLAAKTWGGCNHIINNVSIPTGGRFYGPNPRARIPRLS
ELVHYCGGSDLFDESMFIQMERHILDTLNWDVYEPMINDYILNVDENCLIQYELYKNQ
LQNNNSNGKEWSCKRKSQSSDDSDATVEEHISSSPQSTGLDGDTTTMDEDEELNSKIK
LINLKRFLIDLSCWQYNLLKFELYEICNGMFSIINKFTNQDQGPFLSMPIGNDINSNT
QTQVFSIIINGIVNSPPSLVEVYKEQYGIVPFILQVKDYNLELQKKLQLASTIDLTRK
IAVNSRYFDQNASSSSVSSPSTYSSGTNYTPMRNFSAQSDNSVFSTTNIDHSSPITPH
MYTFNQFKNESACDSAISVSSLPNQTQNGNMPLSSNYQNMMLEERNKENRIPNSSSAE
IPQRAKFMTTGIFQNTGELTNRASSISLSLRNHNSSQL"
gene <664752..>665522
/gene="ROT1"
/locus_tag="YMR200W"
/db_xref="GeneID:855240"
mRNA <664752..>665522
/gene="ROT1"
/locus_tag="YMR200W"
/product="Rot1p"
/transcript_id="NM_001182707.1"
/db_xref="GeneID:855240"
CDS 664752..665522
/gene="ROT1"
/locus_tag="YMR200W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:16567426]"
/experiment="EXISTENCE:direct assay:GO:0051082 unfolded
protein binding [PMID:18508919]"
/experiment="EXISTENCE:genetic interaction:GO:0006457
protein folding [PMID:16874095]"
/experiment="EXISTENCE:genetic interaction:GO:0006487
protein N-linked glycosylation [PMID:22492205]"
/experiment="EXISTENCE:genetic interaction:GO:0007118
budding cell apical bud growth [PMID:17606994]"
/experiment="EXISTENCE:genetic interaction:GO:0034975
protein folding in endoplasmic reticulum [PMID:16874095]"
/experiment="EXISTENCE:genetic interaction:GO:0035269
protein O-linked mannosylation [PMID:22492205]"
/experiment="EXISTENCE:mutant phenotype:GO:0006458 'de
novo' protein folding [PMID:18508919]"
/experiment="EXISTENCE:mutant phenotype:GO:0007118 budding
cell apical bud growth [PMID:17606994]"
/experiment="EXISTENCE:mutant phenotype:GO:0009272
fungal-type cell wall biogenesis [PMID:9545237]"
/experiment="EXISTENCE:mutant phenotype:GO:0030950
establishment or maintenance of actin cytoskeleton
polarity [PMID:17606994]"
/experiment="EXISTENCE:mutant phenotype:GO:0051082
unfolded protein binding [PMID:18508919]"
/experiment="EXISTENCE:physical interaction:GO:0006458 'de
novo' protein folding [PMID:18508919]"
/experiment="EXISTENCE:physical interaction:GO:0006487
protein N-linked glycosylation [PMID:22492205]"
/note="Molecular chaperone involved in protein folding in
ER; mutation causes defects in cell wall synthesis and
lysis of autophagic bodies, suppresses tor2 mutations, and
is synthetically lethal with kar2-1 and with rot2
mutations; involved in N-linked glycosylation and
O-mannosylation; transmembrane helix Ser250 is essential
for Rot1p to interact with other membrane components and
exert its functional role, avoiding exposure of Ser
H-bonding group at lipid-exposed surface"
/codon_start=1
/product="Rot1p"
/protein_id="NP_013927.1"
/db_xref="GeneID:855240"
/db_xref="SGD:S000004813"
/translation="MWSKKFTLKKLILGGYLFAQKVYCEDESNSIYGTWSSKSNQVFT
GPGFYDPVDELLIEPSLPGLSYSFTEDGWYEEATYQVSGNPRNPTCPMASLIYQHGTY
NISENGTLVLNPIEVDGRQLFSDPCNDDGVSTYSRYNQTETFKEYAVGIDPYHGIYTL
QLYQYDGTPMQPLYLAYRPPMMLPTETLNPTSSATSTDDPSSNKKRSLRSLVRRSLEN
RHKTNAIKRQNTSFLTSNAIWYISAGMLGVGSLLFLAF"
gene complement(<665845..>667044)
/gene="RAD14"
/locus_tag="YMR201C"
/db_xref="GeneID:855241"
mRNA complement(join(<665845..666933,667018..>667044))
/gene="RAD14"
/locus_tag="YMR201C"
/product="DNA repair protein RAD14"
/transcript_id="NM_001182708.1"
/db_xref="GeneID:855241"
CDS complement(join(665845..666933,667018..667044))
/gene="RAD14"
/locus_tag="YMR201C"
/experiment="EXISTENCE:direct assay:GO:0000715
nucleotide-excision repair, DNA damage recognition
[PMID:8516285]"
/experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA
binding [PMID:8516285|PMID:23925126]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9852079]"
/experiment="EXISTENCE:direct assay:GO:0008270 zinc ion
binding [PMID:8516285]"
/experiment="EXISTENCE:physical interaction:GO:0000110
nucleotide-excision repair factor 1 complex
[PMID:8621533]"
/note="Subunit of Nucleotide Excision Repair Factor 1
(NEF1); recognizes and binds damaged DNA during nucleotide
excision repair (NER); also involved in regulation of
transcription; contains zinc finger motif; homolog of
human XPA protein"
/codon_start=1
/product="DNA repair protein RAD14"
/protein_id="NP_013928.1"
/db_xref="GeneID:855241"
/db_xref="SGD:S000004814"
/translation="MTPEQKAKLEANRKLAIERLRKRGILSSDQLNRIESRNEPLKTR
PLAVTSGSNRDDNAAAAVHVPNHNGQPSALANTNTNTTSLYGSGVVDGSKRDASVLDK
RPTDRIRPSIRKQDYIEYDFATMQNLNGGYINPKDKLPNSDFTDDQEFESEFGSKKQK
TLQDWKKEQLERKMLYENAPPPEHISKAPKCIECHINIEMDPVLHDVFKLQVCKQCSK
EHPEKYALLTKTECKEDYFLTDPELNDEDLFHRLEKPNPHSGTFARMQLFVRCEVEAF
AFKKWGGEEGLDEEWQRREEGKAHRREKKYEKKIKEMRLKTRAQEYTNRLREKKHGKA
HIHHFSDPVDGGIDEDGYQIQRRRCTDCGLETEEIDI"
gene complement(667288..667456)
/gene="RNA170"
/locus_tag="YNCM0032C"
/db_xref="GeneID:9164961"
ncRNA complement(667288..667456)
/ncRNA_class="other"
/gene="RNA170"
/locus_tag="YNCM0032C"
/product="RNA170"
/note="RNA of unknown function transcribed by RNA
polymerase III; conserved in other yeast species"
/transcript_id="NR_132247.1"
/db_xref="GeneID:9164961"
/db_xref="SGD:S000114171"
misc_feature 667324..667346
/note="ETC5; Chromosome-organizing-clamp; tethers
chromosomal regions to the nuclear periphery; binds TFIIIC
transcription factor but does not recruit RNA Polymerase
III; can act as a transcription-blocking insulator or as a
heterochromatin barrier element; located within ncRNA
RNA170 which lies between divergently transcribed genes
RAD14 and ERG2"
/db_xref="SGD:S000178149"
gene <667537..>668205
/gene="ERG2"
/locus_tag="YMR202W"
/gene_synonym="END11"
/db_xref="GeneID:855242"
mRNA <667537..>668205
/gene="ERG2"
/locus_tag="YMR202W"
/gene_synonym="END11"
/product="C-8 sterol isomerase ERG2"
/transcript_id="NM_001182709.1"
/db_xref="GeneID:855242"
CDS 667537..668205
/gene="ERG2"
/locus_tag="YMR202W"
/gene_synonym="END11"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0000247 C-8
sterol isomerase activity [PMID:18459942]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process [PMID:18459942]"
/note="C-8 sterol isomerase; catalyzes isomerization of
delta-8 double bond to delta-7 position at an intermediate
step in ergosterol biosynthesis; transcriptionally
down-regulated when ergosterol is in excess; mutation is
functionally complemented by human EBP"
/codon_start=1
/product="C-8 sterol isomerase ERG2"
/protein_id="NP_013929.1"
/db_xref="GeneID:855242"
/db_xref="SGD:S000004815"
/translation="MKFFPLLLLIGVVGYIMNVLFTTWLPTNYMFDPKTLNEICNSVI
SKHNAAEGLSTEDLLQDVRDALASHYGDEYINRYVKEEWVFNNAGGAMGQMIILHASV
SEYLILFGTAVGTEGHTGVHFADDYFTILHGTQIAALPYATEAEVYTPGMTHHLKKGY
AKQYSMPGGSFALELAQGWIPCMLPFGFLDTFSSTLDLYTLYRTVYLTARDMGKNLLQ
NKKF"
gene <668492..>669655
/gene="TOM40"
/locus_tag="YMR203W"
/gene_synonym="ISP42; MOM38"
/db_xref="GeneID:855243"
mRNA <668492..>669655
/gene="TOM40"
/locus_tag="YMR203W"
/gene_synonym="ISP42; MOM38"
/product="Tom40p"
/transcript_id="NM_001182710.1"
/db_xref="GeneID:855243"
CDS 668492..669655
/gene="TOM40"
/locus_tag="YMR203W"
/gene_synonym="ISP42; MOM38"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:11914276|PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0005742
mitochondrial outer membrane translocase complex
[PMID:9774667]"
/experiment="EXISTENCE:direct assay:GO:0008320 protein
transmembrane transporter activity [PMID:9774109]"
/experiment="EXISTENCE:mutant phenotype:GO:0030150 protein
import into mitochondrial matrix [PMID:15590639]"
/note="Component of the TOM (translocase of outer
membrane) complex; responsible for recognition and initial
import steps for all mitochondrially directed proteins;
constitutes the core element of the protein conducting
pore; pre-Tom40p is phosphorylated by PKA, which impairs
its import into mitochondria under non-respiratory
conditions"
/codon_start=1
/product="Tom40p"
/protein_id="NP_013930.1"
/db_xref="GeneID:855243"
/db_xref="SGD:S000004816"
/translation="MSAPTPLAEASQIPTIPALSPLTAKQSKGNFFSSNPISSFVVDT
YKQLHSHRQSLELVNPGTVENLNKEVSRDVFLSQYFFTGLRADLNKAFSMNPAFQTSH
TFSIGSQALPKYAFSALFANDNLFAQGNIDNDLSVSGRLNYGWDKKNISKVNLQISDG
QPTMCQLEQDYQASDFSVNVKTLNPSFSEKGEFTGVAVASFLQSVTPQLALGLETLYS
RTDGSAPGDAGVSYLTRYVSKKQDWIFSGQLQANGALIASLWRKVAQNVEAGIETTLQ
AGMVPITDPLMGTPIGIQPTVEGSTTIGAKYEYRQSVYRGTLDSNGKVACFLERKVLP
TLSVLFCGEIDHFKNDTKIGCGLQFETAGNQELLMLQQGLDADGNPLQALPQL"
gene complement(<670063..>671325)
/gene="INP1"
/locus_tag="YMR204C"
/db_xref="GeneID:855244"
mRNA complement(<670063..>671325)
/gene="INP1"
/locus_tag="YMR204C"
/product="Inp1p"
/transcript_id="NM_001182711.1"
/db_xref="GeneID:855244"
CDS complement(670063..671325)
/gene="INP1"
/locus_tag="YMR204C"
/experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
[PMID:14562095|PMID:23900285]"
/experiment="EXISTENCE:mutant phenotype:GO:0030674
protein-macromolecule adaptor activity [PMID:23900285]"
/experiment="EXISTENCE:mutant phenotype:GO:0045033
peroxisome inheritance [PMID:15928207]"
/note="Peripheral membrane protein of peroxisomes;
involved in peroxisomal inheritance; recruitment to
peroxisomes is mediated by interaction with Pex3p at the
peroxisomal membrane; Inp1p and Pex3p tether peroxisomes
to plasma membrane"
/codon_start=1
/product="Inp1p"
/protein_id="NP_013931.1"
/db_xref="GeneID:855244"
/db_xref="SGD:S000004817"
/translation="MVLSRGETKKNSVRLTAKQEKKPQSTFQTLKQSLKLSNNKKLKQ
DSTQHSNDTNKSVKAKKNGTSSKKTGTQRKRISTQRFSLFTYGNVQVMNSFVPIHNDI
PNSSCIRRNSQVSANNVTESSGVFFNDTQSQDSQNTIKLKPTSLMAKGPIEIYQICTG
FDKLKENIAPFQKSSKASSHDGHVVNYLSIGRHGDIVHPVLPKLQITRLNGAGFKYFI
SFYNPERYWEIEFLPLISQSQSELENSVKAFENVISKICQFSHINEGATIGNNESLSD
KFKLPPTSDIEPPNTEIINNDDDNDDDDDNYDDDDLNYLLDEEYEQGCTDNSFSVISN
TCSNLNASFLYPSDPTDAVSISINEAFKNAIRRTAPVLNIPIAAPSIHSKQQNKRYSS
YPFIDSPPYLQDRHRRFQRRSISGLGDL"
gene complement(<671887..>674766)
/gene="PFK2"
/locus_tag="YMR205C"
/db_xref="GeneID:855245"
mRNA complement(<671887..>674766)
/gene="PFK2"
/locus_tag="YMR205C"
/product="6-phosphofructokinase subunit beta"
/transcript_id="NM_001182712.1"
/db_xref="GeneID:855245"
CDS complement(671887..674766)
/gene="PFK2"
/locus_tag="YMR205C"
/EC_number="2.7.1.11"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:21124907]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16962558]"
/experiment="EXISTENCE:direct assay:GO:0005945
6-phosphofructokinase complex
[PMID:4271029|PMID:6231961|PMID:21241708]"
/experiment="EXISTENCE:direct assay:GO:0006096 glycolytic
process [PMID:3000145]"
/experiment="EXISTENCE:genetic interaction:GO:0003872
6-phosphofructokinase activity [PMID:3007939]"
/experiment="EXISTENCE:genetic interaction:GO:0006096
glycolytic process [PMID:2965996]"
/experiment="EXISTENCE:mutant phenotype:GO:0003872
6-phosphofructokinase activity [PMID:3007939]"
/experiment="EXISTENCE:mutant phenotype:GO:0006096
glycolytic process [PMID:2965996|PMID:27226568]"
/experiment="EXISTENCE:mutant phenotype:GO:0007035
vacuolar acidification [PMID:24860096]"
/experiment="EXISTENCE:mutant phenotype:GO:0051453
regulation of intracellular pH [PMID:24860096]"
/experiment="EXISTENCE:mutant phenotype:GO:0070072
vacuolar proton-transporting V-type ATPase complex
assembly [PMID:24860096]"
/note="Beta subunit of heterooctameric
phosphofructokinase; involved in glycolysis; indispensable
for anaerobic growth; activated by
fructose-2,6-bisphosphate and AMP; mutation inhibits
glucose induction of cell cycle-related genes"
/codon_start=1
/product="6-phosphofructokinase subunit beta"
/protein_id="NP_013932.1"
/db_xref="GeneID:855245"
/db_xref="SGD:S000004818"
/translation="MTVTTPFVNGTSYCTVTAYSVQSYKAAIDFYTKFLSLENRSSPD
ENSTLLSNDSISLKILLRPDEKINKNVEAHLKELNSITKTQDWRSHATQSLVFNTSDI
LAVKDTLNAMNAPLQGYPTELFPMQLYTLDPLGNVVGVTSTKNAVSTKPTPPPAPEAS
AESGLSSKVHSYTDLAYRMKTTDTYPSLPKPLNRPQKAIAVMTSGGDAPGMNSNVRAI
VRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKK
REGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYER
MKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGR
NCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAI
AADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVL
ESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLN
NFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYN
GWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLI
IVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEY
CDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIE
YLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQ
GGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKG
SHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKRVD"
gene <675896..>676837
/locus_tag="YMR206W"
/db_xref="GeneID:855246"
mRNA <675896..>676837
/locus_tag="YMR206W"
/product="uncharacterized protein"
/transcript_id="NM_001182713.1"
/db_xref="GeneID:855246"
CDS 675896..676837
/locus_tag="YMR206W"
/note="hypothetical protein; not an essential gene;
YMR206W has a paralog, YNR014W, that arose from the whole
genome duplication"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013933.1"
/db_xref="GeneID:855246"
/db_xref="SGD:S000004819"
/translation="MLSSSSNRPISAHLTIHYKAIQEEEGEDMRSGAGSGGHHDDYFL
ESNRSPTPNKKHEFIKTVLNINDNDSEFSESCSPREKLHNEGACNTDLFGDFMSKRQQ
RLSNSMNIYDLYQCVHNLSPSNNNHQFIARRFSDSHIPSLHHRQQQQKVTTKNFVQPT
KDIQRIASYAADSDQRVKYLPNYHQSAPSTALSAAESKAAVPRKLPDRDSTQNYVLKL
QLSSPNSQPMSPRTRPGYRPSCSSSNCSSSSSSSACSSVSISDPNNITAYETNNVNPQ
FPSNQPLDISSPCARHHHRRNSIAVKFDKALYKKTTG"
gene complement(<677193..>683564)
/gene="HFA1"
/locus_tag="YMR207C"
/db_xref="GeneID:855247"
mRNA complement(<677193..>683564)
/gene="HFA1"
/locus_tag="YMR207C"
/product="acetyl-CoA carboxylase HFA1"
/transcript_id="NM_001182714.1"
/db_xref="GeneID:855247"
CDS complement(677193..683564)
/gene="HFA1"
/locus_tag="YMR207C"
/EC_number="6.3.4.14"
/EC_number="6.4.1.2"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14562095|PMID:14576278|PMID:14761959|PMID:16823961|P
MID:22842922]"
/experiment="EXISTENCE:genetic interaction:GO:0003989
acetyl-CoA carboxylase activity [PMID:14761959]"
/experiment="EXISTENCE:genetic interaction:GO:0042759
long-chain fatty acid biosynthetic process
[PMID:14761959]"
/note="Mitochondrial acetyl-coenzyme A carboxylase;
catalyzes production of malonyl-CoA in mitochondrial fatty
acid biosynthesis; relocalizes from mitochondrion to
cytoplasm upon DNA replication stress; genetic and
comparative analysis suggests that translation begins at a
non-canonical (Ile) start codon at -372 relative to the
annotated start codon"
/codon_start=1
/product="acetyl-CoA carboxylase HFA1"
/protein_id="NP_013934.1"
/db_xref="GeneID:855247"
/db_xref="SGD:S000004820"
/translation="MRSIRKWAYETFNDEKIIQFVVMATPDDLHANSEYIRMADQYVQ
VPGGTNNNNYANIDLILDVAEQTDVDAVWAGWGHASENPCLPELLASSQRKILFIGPP
GRAMRSLGDKISSTIVAQSAKIPCIPWSGSHIDTIHIDNKTNFVSVPDDVYVRGCCSS
PEDALEKAKLIGFPVMIKASEGGGGKGIRRVDNEDDFIALYRQAVNETPGSPMFVMKV
VTDARHLEVQLLADQYGTNITLFGRDCSIQRRHQKIIEEAPVTITKPETFQRMERAAI
RLGELVGYVSAGTVEYLYSPKDDKFYFLELNPRLQVEHPTTEMISGVNLPATQLQIAM
GIPMHMISDIRKLYGLDPTGTSYIDFKNLKRPSPKGHCISCRITSEDPNEGFKPSTGK
IHELNFRSSSNVWGYFSVGNNGAIHSFSDSQFGHIFAVGNDRQDAKQNMVLALKDFSI
RGEFKTPIEYLIELLETRDFESNNISTGWLDDLILKNLSSDSKLDPTLAIICGAAMKA
YVFTEKVRNKYLELLRRGQVPPKDFLKTKFPVDFIFDNNRYLFNVAQSSEEQFILSIN
KSQCEVNVQKLSSDCLLISVDGKCHTVYWKDDIRGTRLSIDSNTIFLEAELNPTQVIS
PTPGKLVKYLVRSGDHVFAGQQYAEIEIMKMQMPLVAKSDGVIELLRQPGSIIEAGDV
IAKLTLDSPSKANESSLYRGELPVLGPPLIEGSRPNHKLRVLINRLENILNGYHENSG
IETTLKELIKILRDGRLPYSEWDSQISTVRNRLPRQLNEGLGNLVKKSVSFPAKELHK
LMKRYLEENTNDHVVYVALQPLLKISERYSEGLANHECEIFLKLIKKYYAVEKIFENH
DIHEERNLLNLRRKDLTNLKKILCISLSHANVVAKNKLVTAILHEYEPLCQDSSKMSL
KFRAVIHDLASLESKWAKEVAVKARSVLLRGIFPPIKKRKEHIKTLLQLHIKDTGAEN
IHSRNIYSCMRDFGNLIHSNLIQLQDLFFFFGHQDTALSSIASEIYARYAYGNYQLKS
IKIHKGAPDLLMSWQFSSLRNYLVNSDGESDEFTKLSKPPSTSGKSSANSFGLLVNMR
ALESLEKTLDEVYEQIHIPEERLSSGENSLIVNILSPIRYRSENDLIKTLKIKLHENE
RGLSKLKVNRITFAFIAANAPAVKFYSFDGTTYDEISQIRNMDPSYEAPLELGKMSNY
KIRSLPTYDSSIRIFEGISKFTPLDKRFFVRKIINSFMYNDQKTTEENLKAEINAQVV
YMLEHLGAVDISNSDLNHIFLSFNTVLNIPVHRLEEIVSTILKTHETRLFQERITDVE
ICISVECLETKKPAPLRLLISNKSGYVVKIETYYEKIGKNGNLILEPCSEQSHYSQKS
LSLPYSVKDWLQPKRYKAQFMGTTYVYDFPGLFHQAAIQQWKRYFPKHKLNDSFFSWV
ELIEQNGNLIKVNREPGLNNIGMVAFEIMVQTPEYPEGRNMIVISNDITYNIGSFGPR
EDLFFDRVTNYARERGIPRIYLAANSGAKLGIAEELIPLFRVAWNDPSDPTKGFQYLY
LAPKDMQLLKDSGKGNSVVVEHKMVYGEERYIIKAIVGFEEGLGVECLQGSGLIAGAT
SKAYRDIFTITAVTCRSVGIGSYLVRLGQRTIQVEDKPIILTGASAINKVLGTDIYTS
NLQIGGTQIMYKNGIAHLTASNDMKAIEKIMTWLSYVPAKRDMSPPLLETMDRWDRDV
DFKPAKQVPYEARWLIEGKWDSNNNFQSGLFDKDSFFETLSGWAKGVIVGRARLGGIP
VGVIAVETKTIEEIIPADPANLDSSEFSVKEAGQVWYPNSAFKTAQTINDFNYGEQLP
LIILANWRGFSGGQRDMYNEVLKYGSFIVDALVDYKQPILIYIPPFGELRGGSWVVID
PTINPEQMEMYADVESRGGVLEPDGVVSIKYRKEKMIETMIRLDSTYGHLRRTLTEKK
LSLEKQNDLTKRLKIRERQLIPIYNQISIQFADLHDRSTRMLVKGVIRNELEWKKSRR
FLYWRLRRRLNEGQVIKRLQKKTCDNKTKMKYDDLLKIVQSWYNDLDVNDDRAVVEFI
ERNSKKIDKNIEEFEISLLIDELKKKFEDRRGNIVLEELTRLVDSKRKR"
gene <684467..>685798
/gene="ERG12"
/locus_tag="YMR208W"
/gene_synonym="RAR1"
/db_xref="GeneID:855248"
mRNA <684467..>685798
/gene="ERG12"
/locus_tag="YMR208W"
/gene_synonym="RAR1"
/product="mevalonate kinase"
/transcript_id="NM_001182715.1"
/db_xref="GeneID:855248"
CDS 684467..685798
/gene="ERG12"
/locus_tag="YMR208W"
/gene_synonym="RAR1"
/EC_number="2.7.1.36"
/experiment="EXISTENCE:direct assay:GO:0004496 mevalonate
kinase activity [PMID:16477420|PMID:1645230]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0006696 ergosterol
biosynthetic process [PMID:1645230]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process [PMID:200835]"
/experiment="EXISTENCE:mutant phenotype:GO:0010142
farnesyl diphosphate biosynthetic process, mevalonate
pathway [PMID:200835]"
/experiment="EXISTENCE:mutant phenotype:GO:0019287
isopentenyl diphosphate biosynthetic process, mevalonate
pathway [PMID:200835]"
/note="Mevalonate kinase; acts in the biosynthesis of
isoprenoids and sterols, including ergosterol, from
mevalonate; human MVK functionally complements the
lethality of the erg12 null mutation"
/codon_start=1
/product="mevalonate kinase"
/protein_id="NP_013935.1"
/db_xref="GeneID:855248"
/db_xref="SGD:S000004821"
/translation="MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISES
SAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPL
LAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAM
AYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDS
HNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAM
GECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLEL
IKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLG
GTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS"
gene complement(<685911..>687284)
/locus_tag="YMR209C"
/db_xref="GeneID:855249"
mRNA complement(<685911..>687284)
/locus_tag="YMR209C"
/product="uncharacterized protein"
/transcript_id="NM_001182716.1"
/db_xref="GeneID:855249"
CDS complement(685911..687284)
/locus_tag="YMR209C"
/note="Putative S-adenosylmethionine-dependent
methyltransferase; SWAT-GFP and mCherry fusion proteins
localize to the endoplasmic reticulum and vacuole
respectively; YMR209C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013936.1"
/db_xref="GeneID:855249"
/db_xref="SGD:S000004822"
/translation="MVSSLASNIILALVVVLMTLLRQNKPLQRWFVSYVEKLLSRKSN
LAQKVSVLSPSLKLVDVEKSISADQSNLSKINYQIPTLPDLTGNLIRLHEYRARGEGY
NGLLFRRARQLNGISEDQLQKLGYFTKLMKNNEGIRENARVIDKIIEFTLGKLIHSNE
HDEEFTEEIEKICAEHGYKIKDGHLIQLNPDFVFPIVSSRGSQSVVHEALAHLCRDFS
SYYSVERDPLQNFIISRINHHVISAGDMKEKILIVTPGAGVGGLSHTLATTFPKIQVD
SIELSALMYICNLFALEYKHDVKIRPFVQQYSCQTVFDNQLRSLSADLSKVGHRSNLD
PLWGDFTRYSPISKDYDKIIICSAYFIDTAENMFEYLSSIEALKKYCKELHWVNVGPL
KYGTKPLVQFTGDELSRLRKIRGWKDLVEEYEVDSSKGLNGYLTDYESMYQGYYGLLK
FHSVFES"
gene <687516..>688865
/gene="MGL2"
/locus_tag="YMR210W"
/db_xref="GeneID:855250"
mRNA <687516..>688865
/gene="MGL2"
/locus_tag="YMR210W"
/product="putative carboxylic ester hydrolase"
/transcript_id="NM_001182717.1"
/db_xref="GeneID:855250"
CDS 687516..688865
/gene="MGL2"
/locus_tag="YMR210W"
/EC_number="3.1.1.23"
/experiment="EXISTENCE:direct assay:GO:0004806
triglyceride lipase activity [PMID:29225428]"
/experiment="EXISTENCE:direct assay:GO:0047372
acylglycerol lipase activity [PMID:26991558]"
/experiment="EXISTENCE:genetic interaction:GO:0006641
triglyceride metabolic process [PMID:26991558]"
/experiment="EXISTENCE:genetic interaction:GO:0047372
acylglycerol lipase activity [PMID:26991558]"
/experiment="EXISTENCE:genetic interaction:GO:0051792
medium-chain fatty acid biosynthetic process
[PMID:16361250]"
/experiment="EXISTENCE:mutant phenotype:GO:0047372
acylglycerol lipase activity [PMID:26991558]"
/note="Monoacylglycerol and triacylglycerol lipase; MAG
lipase with preference for palmitoyl-MAG; TAG lipase
involved in TAG catabolism; minor role in medium-chain
fatty acid ethyl ester biosynthesis; contains an
alpha/beta hydrolase domain and a typical lipase motif
(GXSXG); similar to acyltransferases, Eeb1p, Eht1p, and
human ABHD1"
/codon_start=1
/product="putative carboxylic ester hydrolase"
/protein_id="NP_013937.1"
/db_xref="GeneID:855250"
/db_xref="SGD:S000004823"
/translation="MRLKELLPNFLIVHQEVPEDPIAFKSTDKRENENKEITIPELID
TKVPELADGATDTLYGLLVNGHLQTAYGSFRHFDNIYKVQYKRMIIKYPHGGEGTVDF
AVNGRSTKRRKVEKEYVPTSQPVFNGNLKRRYSYYSPDDPKLNSDDAKPMLIILHGLT
GGSRESYVRAIVHEITTKYDFEACVFNARGCCYSAITTPLLYNGGWTNDIRYCVNDLR
KRFPNRKFYMMGFSLGASIMTNYLGEESDRTKIECAISVSNPFDLYNSAYFINSTPMG
SRFYSPALGHNLLRMVRNHLSTLEENPDFKDVIEKHLKKIRTVRQFDNLLTGPMFGYK
NAEEYYKNASSYKRIPGIRTPFIALHAQDDPIVGGDLPIDQIKSNPYTLLLETSTGGH
VGWFKDRSGRRWYAEPLCRFLKIFHDEITVKGLKPDLENVQLPDPNCEPIATTFRAN"
gene <689083..>690510
/gene="DML1"
/locus_tag="YMR211W"
/db_xref="GeneID:855251"
mRNA <689083..>690510
/gene="DML1"
/locus_tag="YMR211W"
/product="Dml1p"
/transcript_id="NM_001182718.1"
/db_xref="GeneID:855251"
CDS 689083..690510
/gene="DML1"
/locus_tag="YMR211W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14690591]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14690591]"
/experiment="EXISTENCE:mutant phenotype:GO:0000002
mitochondrial genome maintenance [PMID:12702300]"
/experiment="EXISTENCE:mutant phenotype:GO:0006276 plasmid
maintenance [PMID:12702300]"
/note="Essential protein involved in mtDNA inheritance;
may also function in the partitioning of the mitochondrial
organelle or in the segregation of chromosomes, exhibits
regions similar to members of a GTPase family"
/codon_start=1
/product="Dml1p"
/protein_id="NP_013938.1"
/db_xref="GeneID:855251"
/db_xref="SGD:S000004824"
/translation="MHEVVTISVSQRANHLTTQFFNIQEGYLQLSKEQQVNDSKIFLN
SVVDKVSKTISYAPRALLWDARTGNGSLGTYQYSESQDYHFGNEDKFKEQTVIKTHPR
IPKSEYQSSLDAGAPLPCLNRENTMYWSDYSKLIYGPSSFNILRNWYHDTENPNQPDF
QNLGERKFDRYSIGYDEFTENYLQEFFDGNLHRELEKCDTLQGFNLVSDMESGWGGFS
SALLVELRNELPKKAVFSWGHNEDDPFTDDFPMKRLSKKWLPIISNKLRSTINMMQES
DLYFPLYAAPGLTNWETAGKSCRIFDSINATISQSNLEQRKTMDYLTTAITLGYSSRN
MVTGMVIGDTDYSFCSRVLPFKNSHKPNSTHIFSKSFIDRGNQTHKHHSEPDSRSKMI
EMYTHRYFPSDTIPTEFSNDREFVLELESSEKNRDIFKHWNEFVVRYFKNDSDREELK
NELSDYASAYESGWYEDEDSGDDDM"
gene complement(<690695..>693043)
/gene="EFR3"
/locus_tag="YMR212C"
/db_xref="GeneID:855252"
mRNA complement(<690695..>693043)
/gene="EFR3"
/locus_tag="YMR212C"
/product="Efr3p"
/transcript_id="NM_001182719.1"
/db_xref="GeneID:855252"
CDS complement(690695..693043)
/gene="EFR3"
/locus_tag="YMR212C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:19075114]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0072659 protein
localization to plasma membrane [PMID:19075114]"
/note="Protein required for Stt4-containing PI kinase
complex localization; required for Stt4-containing
phosphoinositide (PI) kinase patch assembly at plasma
membrane; recruited to plasma membrane via conserved basic
patch near N-terminus; exhibits synthetic lethal genetic
interactions with PHO85; mutations in human homolog EFR3A
implicated in autism spectrum disorders"
/codon_start=1
/product="Efr3p"
/protein_id="NP_013939.1"
/db_xref="GeneID:855252"
/db_xref="SGD:S000004825"
/translation="MQLSMRMMFTPKHQKLVNQCYPTGRTTDKKPKSSETSYLLYYVN
SRRSKLEKVSTYLIKRSTSDLNHRRIGNIAVTLDLMNKIVLHCKENLNVFVKDFLYIM
NKVLSNNNFNNDVSVVELIELAFSSICQNLDDVLCNGDMEFVQLYQNFVDLFFKIVTE
RIHNDDMLLKCCIDISNTNSVSSNPQLNHFVSKSVAYTISKFQERNPKFKTLSLEAAL
ESNLGKRLSRTQTRTIGLDKAAEDNHDLSVKALQSYFNTTETDKLNLSIRTLLRCLQS
TPNKELLEFVCNGIPVQLRYIVILLLVRQLSDKDKNVNPIVSLKLMSSLLVSDVSIVG
LSVLDIMRKLLNFQLKNATNKEVVAQSCITMTDLNHKTYYAEQTSDMLYELLLKLKSD
TVKDVEKNAVVEDIDFLVEHITQPSISLELFIDLAHYMKNHIICLFNIVETEVPSSIL
FSKLYSLLRELDSHGVQKEMMEEIFDKYGKMALLSGLNYFLENVSEPEYTYYSYHLQA
ANFLKLNDYKSQTEYKMQTRTLFTKEDLLSYYSDTGSNKYSKKGAQILLSRDNQISTS
DLLSDSQVRTTPLEYKNVPNAIFSNGKAVYDNNDFAAKQNKFDNSIDDNIEEANDTVI
SDANAKGSIYRFVAEDARSWKTMRATAPKVSDLKKTMNEKNIPNNMKRDGSFRGSQSV
KSRVTNITFLLNELKTFSDDANKIKDPDEENIVGLDKIDVARSNSLRLAPISSLSDRS
SIGNRKSFLQKTATGENQNDDFKDANEDLHSLSSRGKIFSST"
gene <693381..>695153
/gene="CEF1"
/locus_tag="YMR213W"
/gene_synonym="NTC85"
/db_xref="GeneID:855253"
mRNA <693381..>695153
/gene="CEF1"
/locus_tag="YMR213W"
/gene_synonym="NTC85"
/product="Cef1p"
/transcript_id="NM_001182720.1"
/db_xref="GeneID:855253"
CDS 693381..695153
/gene="CEF1"
/locus_tag="YMR213W"
/gene_synonym="NTC85"
/experiment="EXISTENCE:direct assay:GO:0000974 Prp19
complex [PMID:10092627]"
/experiment="EXISTENCE:direct assay:GO:0071006 U2-type
catalytic step 1 spliceosome [PMID:10092627]"
/experiment="EXISTENCE:mutant phenotype:GO:0000350
generation of catalytic spliceosome for second
transesterification step [PMID:22408182]"
/experiment="EXISTENCE:mutant phenotype:GO:0000386 second
spliceosomal transesterification activity [PMID:22408182]"
/experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA
splicing, via spliceosome [PMID:10092627]"
/note="Essential splicing factor; associated with Prp19p
and the spliceosome, contains an N-terminal c-Myb DNA
binding motif necessary for cell viability but not for
Prp19p association, evolutionarily conserved and
homologous to S. pombe Cdc5p"
/codon_start=1
/product="Cef1p"
/protein_id="NP_013940.1"
/db_xref="GeneID:855253"
/db_xref="SGD:S000004826"
/translation="MPPVPIYVKGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKT
ARQSELRWNEYLNPKLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERY
NRLLESEDSGGAALSTGVTDLKAGDINPNAETQMARPDNGDLEDEEKEMLAEARARLL
NTQGKKATRKIRERMLEESKRIAELQKRRELKQAGINVAIKKPKKKYGTDIDYNEDIV
YEQAPMPGIYDTSTEDRQIKKKFEQFERKVNRKGLDGNKDKPSKKNKDKKRKHDENEH
VEKAALGESTTLTDEYKKPKLILSAPGTKQGKVTYKKKLESKRQKLIEAQATGTVLTP
KELLPHDSGQEDNERSNIKSGKQLKSRIRKFLVQMFASLPSPKNDFEIVLSEDEKEED
AEIAEYEKEFENERAMNEEDNFIEPPSQNDAPRVSLVAVPLAYSTLPIPEFKNNPQSA
IDNKYNLLVANAINKEPHMVPEDTVDFLKEVESRMQHITQGRTSMKIQFKTAMPPTEV
LLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPALIEGQRKYYADYYAY
RQEIRSLEGRRKRLQAMLNSSSSI"
gene <695350..>696483
/gene="SCJ1"
/locus_tag="YMR214W"
/db_xref="GeneID:855254"
mRNA <695350..>696483
/gene="SCJ1"
/locus_tag="YMR214W"
/product="Scj1p"
/transcript_id="NM_001182721.1"
/db_xref="GeneID:855254"
CDS 695350..696483
/gene="SCJ1"
/locus_tag="YMR214W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic
reticulum lumen [PMID:7744969]"
/experiment="EXISTENCE:mutant phenotype:GO:0006986
response to unfolded protein [PMID:9817751]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:11381090]"
/experiment="EXISTENCE:mutant phenotype:GO:0034975 protein
folding in endoplasmic reticulum [PMID:9817751]"
/experiment="EXISTENCE:mutant phenotype:GO:0051087
protein-folding chaperone binding [PMID:9817751]"
/note="One of several homologs of bacterial chaperone
DnaJ; located in the ER lumen where it cooperates with
Kar2p to mediate maturation of proteins"
/codon_start=1
/product="Scj1p"
/protein_id="NP_013941.2"
/db_xref="GeneID:855254"
/db_xref="SGD:S000004827"
/translation="MIPKLYIHLILSLLLLPLILAQDYYAILEIDKDATEKEIKSAYR
QLSKKYHPDKNAGSEEAHQKFIEVGEAYDVLSDPEKKKIYDQFGADAVKNGGGGGGPG
GPGAGGFHDPFDIFERMFQGGHGGPGGGFGQRQRQRGPMIKVQEKLSLKQFYSGSSIE
FTLNLNDECDACHGSGSADGKLAQCPDCQGRGVIIQVLRMGIMTQQIQQMCGRCGGTG
QIIKNECKTCHGKKVTKKNKFFHVDVPPGAPRNYMDTRVGEAEKGPDFDAGDLVIEFK
EKDTENMGYRRRGDNLYRTEVLSAAEALYGGWQRTIEFLDENKPVKLSRPAHVVVSNG
EVEVVKGFGMPKGSKGYGDLYIDYVVVMPKTFKSGQNMLKDEL"
gene <696796..>698370
/gene="GAS3"
/locus_tag="YMR215W"
/db_xref="GeneID:855255"
mRNA <696796..>698370
/gene="GAS3"
/locus_tag="YMR215W"
/product="putative 1,3-beta-glucanosyltransferase"
/transcript_id="NM_001182722.1"
/db_xref="GeneID:855255"
CDS 696796..698370
/gene="GAS3"
/locus_tag="YMR215W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836|PMID:17507646]"
/experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
cell wall [PMID:10383953|PMID:15781460]"
/note="Putative 1,3-beta-glucanosyltransferase; has
similarity go other GAS family members; low abundance,
possibly inactive member of the GAS family of
GPI-containing proteins; localizes to the cell wall; mRNA
induced during sporulation"
/codon_start=1
/product="putative 1,3-beta-glucanosyltransferase"
/protein_id="NP_013942.1"
/db_xref="GeneID:855255"
/db_xref="SGD:S000004828"
/translation="MQLSKSILLAALAATPSLVNAMLPIHIKNYRFIKPSSATNSESD
NEVFFVKGVDYQPGGSSGYDADSDTDILSDPEVCARDAYAFQQLGVNTVRIYSLNPDL
NHDKCMTIFNNAGIYAILDVNSGNYGESLNRADPSGTYDSLYLSRVFKFIDAFKNYPN
VLGFFSGNEVINDQSDYAKIDPPYIRAVQRDMKQYISKHANRSIPVGYSAADNTDLRL
ATFKYLQCNSLDGNKVNDDLDISKSDFFGLNTYEWCSGTSSWESSGYDKLNSTFEDAV
IPLIFSEYGCNKNTPRTFDEVSEGLYGGLKNVFSGGLVYEYTEEANNYGLVKLDDSGS
LTYKDDFVNLESQLKNVSLPTTKESEISSDSIYKCDNSAITNIYSGFGTNNFTLPSQP
AEIANMIEYGVNGTNTGKILTDYAVPTTFNYTIKNNKDDTISATISYDKANSLNELDV
TATTVAKSASTSQSSSRSLTSSTSPSSSTGSSSSTGSSSASSSSKSKGVGNIVNVSFS
QSGYLALFAGLISALL"
gene complement(<698811..>701039)
/gene="SKY1"
/locus_tag="YMR216C"
/db_xref="GeneID:855256"
mRNA complement(<698811..>701039)
/gene="SKY1"
/locus_tag="YMR216C"
/product="serine/threonine protein kinase SKY1"
/transcript_id="NM_001182723.1"
/db_xref="GeneID:855256"
CDS complement(698811..701039)
/gene="SKY1"
/locus_tag="YMR216C"
/EC_number="2.7.11.1"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity [PMID:16319894]"
/experiment="EXISTENCE:direct assay:GO:0004674 protein
serine/threonine kinase activity
[PMID:11233987|PMID:17517895]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10318902]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:31399582]"
/experiment="EXISTENCE:direct assay:GO:0035617 stress
granule disassembly [PMID:31399582]"
/experiment="EXISTENCE:genetic interaction:GO:0006376 mRNA
splice site recognition [PMID:11565750]"
/experiment="EXISTENCE:mutant phenotype:GO:0006873
intracellular monoatomic ion homeostasis [PMID:11113192]"
/experiment="EXISTENCE:mutant phenotype:GO:0008361
regulation of cell size [PMID:12089449]"
/experiment="EXISTENCE:mutant phenotype:GO:0009410
response to xenobiotic stimulus [PMID:11585720]"
/experiment="EXISTENCE:mutant phenotype:GO:0030003
intracellular monoatomic cation homeostasis
[PMID:12225850]"
/experiment="EXISTENCE:mutant phenotype:GO:0042307
positive regulation of protein import into nucleus
[PMID:10952997]"
/note="SR protein kinase (SRPK); involved in mRNA 3'
splice site recognition with Prp8p and Cdc40p;
phosphorylates one or more SR dipeptides on mRNA export
factors Npl3p and Gbp2p to stimulate cytoplasmic release
of mRNA and Mtr10p-mediated nuclear reimport; component of
stress granules that regulates granule disassembly during
recovery from stress; modulates cation uptake and
homeostasis through membrane transporters; contains
prion-like domains; similar to human SRPK1"
/codon_start=1
/product="serine/threonine protein kinase SKY1"
/protein_id="NP_013943.1"
/db_xref="GeneID:855256"
/db_xref="SGD:S000004829"
/translation="MGSSINYPGFVTKSAHLADTSTDASISCEEATSSQEAKKNFFQR
DYNMMKKAPAPTKSKLSLALQTSKSSSSANGTVQEDTSSKTEDFSTKSIKKKPDSGVE
SHVSIQSDSGPQSDSDLDSDSSISSCDERNEESLKDYRPGGYHPAFKGEPYKDARYIL
VRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKED
SMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQ
LLLGLDYMHRRCGIIHTDIKPENVLMEIGDVEGIVQMVEALDKQKREAKRLQRHVSRS
SDITANDSSDEKWAECQTSMPCGSSSNSKSRSIEKDLSKRCFRRPRRHTIITGSQPLP
SPISSSNFFEMRAHFCGSSHNSFSSVSGNRNIPSSINNNSINNGIGIKNSNNSFLNSV
PHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFD
ISNISQSSDTNGPYISNTMDSNSNVSTDINSPENLIQIKIADLGNACWYDEHYTNSIQ
TREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIE
LLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDF
LSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEEVRDHK
RH"
gene <701790..>703367
/gene="GUA1"
/locus_tag="YMR217W"
/db_xref="GeneID:855257"
mRNA <701790..>703367
/gene="GUA1"
/locus_tag="YMR217W"
/product="GMP synthase (glutamine-hydrolyzing)"
/transcript_id="NM_001182724.1"
/db_xref="GeneID:855257"
CDS 701790..703367
/gene="GUA1"
/locus_tag="YMR217W"
/EC_number="6.3.5.2"
/experiment="EXISTENCE:mutant phenotype:GO:0003922 GMP
synthase (glutamine-hydrolyzing) activity [PMID:8112582]"
/experiment="EXISTENCE:mutant phenotype:GO:0006177 GMP
biosynthetic process [PMID:20980241]"
/note="GMP synthase; highly conserved enzyme that
catalyzes the second step in the biosynthesis of GMP from
inosine 5'-phosphate (IMP); transcription is not subject
to regulation by guanine but is negatively regulated by
nutrient starvation; reduction-of-function mutation
gua1-G388D causes changes in cellular guanine nucleotide
pools, defects in general protein synthesis, and impaired
translation of GCN4 mRNA"
/codon_start=1
/product="GMP synthase (glutamine-hydrolyzing)"
/protein_id="NP_013944.1"
/db_xref="GeneID:855257"
/db_xref="SGD:S000004830"
/translation="MAAGEQVSNMFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCT
QKISELGWTPKGVILSGGPYSVYAEDAPHVDHAIFDLNVPILGICYGMQELAWINGKQ
VGRGDKREYGPATLKVIDDSNSLFKGMNDSTVWMSHGDKLHGLPTGYKTIATSDNSPY
CGIVHETKPIYGIQFHPEVTHSTQGKTLLKNFAVDLCHAKQNWTMENFIDTEINRIRK
LVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVLRLNEAANVKKTLVEG
LGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEKIKPKDGKEIQFLL
QGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRHLGELLG
IPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLYNQISQAFAC
LLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIVNEVDGVA
RVTYDITSKPPATVEWE"
gene complement(<703579..>706887)
/gene="TRS130"
/locus_tag="YMR218C"
/db_xref="GeneID:855258"
mRNA complement(<703579..>706887)
/gene="TRS130"
/locus_tag="YMR218C"
/product="transport protein particle complex II subunit
TRS130"
/transcript_id="NM_001182725.1"
/db_xref="GeneID:855258"
CDS complement(703579..706887)
/gene="TRS130"
/locus_tag="YMR218C"
/experiment="EXISTENCE:direct assay:GO:0005769 early
endosome [PMID:16314430]"
/experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi
network [PMID:16314430]"
/experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII
protein complex [PMID:11239471]"
/experiment="EXISTENCE:genetic interaction:GO:0005085
guanyl-nucleotide exchange factor activity
[PMID:17041589]"
/experiment="EXISTENCE:mutant phenotype:GO:0005085
guanyl-nucleotide exchange factor activity
[PMID:17041589]"
/experiment="EXISTENCE:mutant phenotype:GO:0006891
intra-Golgi vesicle-mediated transport
[PMID:11239471|PMID:16314430]"
/experiment="EXISTENCE:mutant phenotype:GO:0016236
macroautophagy [PMID:23078654]"
/experiment="EXISTENCE:mutant phenotype:GO:0032258
cytoplasm to vacuole transport by the Cvt pathway
[PMID:23078654]"
/experiment="EXISTENCE:mutant phenotype:GO:0034498 early
endosome to Golgi transport [PMID:16314430]"
/experiment="EXISTENCE:physical interaction:GO:0005085
guanyl-nucleotide exchange factor activity
[PMID:17041589]"
/note="Component of transport protein particle (TRAPP)
complex II; TRAPPII is a multimeric guanine
nucleotide-exchange factor for the GTPase Ypt1p,
regulating intra-Golgi and endosome-Golgi traffic"
/codon_start=1
/product="transport protein particle complex II subunit
TRS130"
/protein_id="NP_013945.1"
/db_xref="GeneID:855258"
/db_xref="SGD:S000004831"
/translation="MDKEIYCGSVPVSYFDPFDLFESLRPEFQQILPLDNIHWKAFDG
TVRTVNRLPIELIPEGRGEADKSNDEQPFIRFLIVNCISIDQYRAKVRPLVRQWLPNL
ESVSSSTGEKMIYKPIILLYANSEVVDSNLFKSVSLMEKFGKDFPHVQTLEVRSVYRS
PKERQEFWNQFSQKIKASVLSIFQKRLTHLQHSLANLQKGNNFEEQLLTREKLYELYV
VFNILEDASLELQKIKKEILRRNMNMPDGKLQVPFESSSKSDESLGSIIIEGTLDKFQ
LHKYFFIRRLRLLKLEDQTLTAFVGAFQLIKNFIESISIEYRKSVRLLEFKHYFITSM
LSYFEFENVSNPLLCEIKAELLMLKRDNWVQGVMATSGYRLMDKNYPNSDVKYKFDLL
KETFVDETVFQENFLTLTKEILSLFNKCEGKRQRIVDILSIEIGLLYYQGKKYEEAVS
LFLSCYEYYTQTNWNSIGLKILQVFIDSLSHCPKLDVLQIDGESVSASAVLTNAFLNI
LKLCKDNDSKEIWWKKFMDLQMKNNIHLMYPLDGLFEVTLNSKVHLARANVSAIEVNL
KSYGFPEDISTKTMRLSLKNMGGDVIVFGASDFLLKKGENKLILECRDIMYGEFSLLS
FEIIVEGITFVKEFPENQDEFIVVPEIYCKESTKVLVKQAHNLNLGEYALELKSVQSD
ALESLQVEVEVQKNIGNMKNLPVSFSMDEIQARKRYNTPFENVRLEYYLLDQITAFDL
IIKTSFTKKNDQGTFGETKKVRIQCYLQLSVSVEDIFKKDIFFFKFLLNSSVREEPVI
LYSSELSAPDTRNDYNIRGDYIATTPALITFDGNESFINCYEITANNNFDSKDIFNLK
VRYNTLKEQLDCFITDAVLIEGDVEWFILFEKWKTFWELEILKKLKYDYDAFKENRII
RLLKTSIDLNKTKSKIRNLCIEKAVLDKILICLNKVSRGIAVCNTDMDEYVRNLVPKQ
LTVPVQLPGFEQFFHVQFEQMETSHDALHDTIATIGNSLSYTVIVENLSGQWGQDVID
DGGYIFEILSSNEWLIHGQKRCAIKEKRKEFEVHLIPLKKGYLNFPRVEITNINGKSC
RVDHSNAFESILIF"
gene <707133..>712109
/gene="ESC1"
/locus_tag="YMR219W"
/db_xref="GeneID:855259"
mRNA <707133..>712109
/gene="ESC1"
/locus_tag="YMR219W"
/product="Esc1p"
/transcript_id="NM_001182726.1"
/db_xref="GeneID:855259"
CDS 707133..712109
/gene="ESC1"
/locus_tag="YMR219W"
/experiment="EXISTENCE:direct assay:GO:0000781 chromosome,
telomeric region [PMID:27122604]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:12417731]"
/experiment="EXISTENCE:mutant phenotype:GO:0031509
subtelomeric heterochromatin formation [PMID:12417731]"
/experiment="EXISTENCE:mutant phenotype:GO:0034398
telomere tethering at nuclear periphery [PMID:27122604]"
/note="Protein involved in telomeric silencing; required
for quiescent cell telomere hypercluster localization at
nuclear membrane vicinity; interacts with PAD4-domain of
Sir4p"
/codon_start=1
/product="Esc1p"
/protein_id="NP_013946.1"
/db_xref="GeneID:855259"
/db_xref="SGD:S000004832"
/translation="MSKKKETFTPRANKLKLTTPRRKLKILSSLLDADEDSKMKDQHG
YSRVHNDKYRVAKPTQHSTLHESISSRRSSHIHNKSLHEDSARALSWVDSLINRGKSI
LTTLEKEDALFERSLEEERQRFQLHDSLMNKYTGNSKSHQRLIDLRKSQYGTDTSFQN
NDEIPLDSFISSPLPDAEDESSSNIDSDKDEDLEGKQSLIKDFDLENDEYELSEEEKN
SDGQSSPSIMILSDEEYAEEGALQDVSNDEYAEEEGQVERKNIGQEQANVENATQISS
SDSSEGQNYSEGVEMELEDDIDVESDAEKDESQGAEGTEHSVDFSKYMQPRTDNTKIP
VIEKYESDEHKVHQRYSEDGAFDFGSVNISVDDESEDEESQAESYSANAENVYHHNEH
ELDDKELIEDIESSDSESQSAQESEQGSEDDFEYKMKNEKSTSEETENTSESRDQGFA
KDAYTKNKVEQQENDEEPEKDDIIRSSLDKNFHGNNNKSEYSENVLENETDPAIVERE
NQINDVEGYDVTGKSVESDLHEHSPDNLYDLAARAMLQFQQSRNSNCPQKEEQVSESY
LGHSNGSNLSGRSLDESEEQIPLKDFTGENNNNLKTDRGDLSSSVEIEVEKVSEKKLD
GSTEKELVPLSTDTTINNSSLGNEDSIYYSLDDADAISENLTDVPLMEIKTTPKYEVV
ISESVYSSTSYEDNTVAMPPQVEYTSPFMNDPFNSLNDDYEKKHDLLKSTLAALAPAF
TKKDAEFVEAGVTKSCLTSTSGHTNIFHTSKETKQVSDLDESTENVTFENENTGDENK
NQSKNFPGVANSTDKSTEDNTDEKYFSAINYTNVTGDSSCEDIIETASNVEENLRYCE
KDMNEAEMSSGDECVKQNDDGSKTQISFSTDSPDNFQESNDNTEFSSTKYKVRNSDLE
DDESLKKELTKAEVVDKLDEEESEDSYEQDYADPEPGNDEGSNENIVKGTKKDTLGIV
EPENEKVNKVHEEETLFEANVSSSVNVQNKDMHTDVINQEAQANYEAGERKYYIQNTD
TEEAHISIIERIDENAIGNNMEIPERSCVEKTHNEVLFERRATTIENTKALENNTNMH
DQVSQACSDSDRDQDSTAEKNVEGSAKHNLDIRVSSSEIESVEPLKPESDRSNIFSSP
IRVIGAVVKGVGKVVDVAESFVKKIDVMDSESDDNVDIGDYNQDIFNKSNSTDASVNM
KSVSSKERDSDEDEAVILGGVTAEAHNDNGNNSRVINIDPTTNGAYEEDSEVFRQQVK
DKENLHKSEEPLVEGLQSEQHFEKKDHSENEEEFDTIYGDITSANIHSNAPDDIKRQQ
LLKNLSDLENYSQRLIEDSRRGKNQEESDEVNTSRERDLTFEKSVNEKYAGAIEEDTF
SELDISIQHPEHEEDLDLSNNQERSIEELNSEPEEAELYELEIEGPTETAASSKMNDD
ERQRGNIPSTDLPSDPPSDKEEVTDSYPYSNSENITAEKSAPTSPEVYEIFSDTPNEV
PMEINDEIPATTLEKHDKTNVTSVLDDRSEHLSSHDVDNEPHDNSINIKVNEGEEPEH
QAVDIPVKVEVKEEQEEMPSKSVLEEQKPSMELINDKSSPENNNDEETNREKDKTKAK
KKSRKRNYNSRRRKRKITEGSSAASNTKRRRGHEPKSRGQNTHPSVDK"
gene <712316..>713671
/gene="ERG8"
/locus_tag="YMR220W"
/db_xref="GeneID:855260"
mRNA <712316..>713671
/gene="ERG8"
/locus_tag="YMR220W"
/product="phosphomevalonate kinase"
/transcript_id="NM_001182727.1"
/db_xref="GeneID:855260"
CDS 712316..713671
/gene="ERG8"
/locus_tag="YMR220W"
/EC_number="2.7.4.2"
/experiment="EXISTENCE:direct assay:GO:0004631
phosphomevalonate kinase activity [PMID:1846667]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006696 ergosterol
biosynthetic process [PMID:1846667]"
/experiment="EXISTENCE:mutant phenotype:GO:0004631
phosphomevalonate kinase activity [PMID:1846667]"
/experiment="EXISTENCE:mutant phenotype:GO:0006696
ergosterol biosynthetic process [PMID:200835]"
/experiment="EXISTENCE:mutant phenotype:GO:0010142
farnesyl diphosphate biosynthetic process, mevalonate
pathway [PMID:200835]"
/experiment="EXISTENCE:mutant phenotype:GO:0019287
isopentenyl diphosphate biosynthetic process, mevalonate
pathway [PMID:200835]"
/experiment="EXISTENCE:mutant phenotype:GO:0031388 organic
acid phosphorylation [PMID:200835]"
/note="Phosphomevalonate kinase; an essential cytosolic
enzyme that acts in the biosynthesis of isoprenoids and
sterols, including ergosterol, from mevalonate"
/codon_start=1
/product="phosphomevalonate kinase"
/protein_id="NP_013947.1"
/db_xref="GeneID:855260"
/db_xref="SGD:S000004833"
/translation="MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPY
GSLQGSDKFEVRVKSKQFKDGEWLYHISPKSGFIPVSIGGSKNPFIEKVIANVFSYFK
PNMDDYCNRNLFVIDIFSDDAYHSQEDSVTEHRGNRRLSFHSHRIEEVPKTGLGSSAG
LVTVLTTALASFFVSDLENNVDKYREVIHNLAQVAHCQAQGKIGSGFDVAAAAYGSIR
YRRFPPALISNLPDIGSATYGSKLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSE
TVKLVQKVKNWYDSHMPESLKIYTELDHANSRFMDGLSKLDRLHETHDDYSDQIFESL
ERNDCTCQKYPEITEVRDAVATIRRSFRKITKESGADIEPPVQTSLLDDCQTLKGVLT
CLIPGAGGYDAIAVITKQDVDLRAQTANDKRFSKVQWLDVTQADWGVRKEKDPETYLD
K"
gene complement(<713931..>715445)
/gene="FMP42"
/locus_tag="YMR221C"
/db_xref="GeneID:855261"
mRNA complement(<713931..>715445)
/gene="FMP42"
/locus_tag="YMR221C"
/product="Fmp42p"
/transcript_id="NM_001182728.1"
/db_xref="GeneID:855261"
CDS complement(713931..715445)
/gene="FMP42"
/locus_tag="YMR221C"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/note="hypothetical protein; the authentic, non-tagged
protein is detected in highly purified mitochondria in
high-throughput studies; physical interaction with Atg27p
suggests a possible role in autophagy; targeted to vacuole
via AP-3 pathway"
/codon_start=1
/product="Fmp42p"
/protein_id="NP_013948.1"
/db_xref="GeneID:855261"
/db_xref="SGD:S000004834"
/translation="MTSTRTLRYAQVACACIWCLFSAGIIFGFAALKPILISEGVYHE
LCDPKDGDRLLCTAQDLKLNFIFALSATVTNIMALPVGKILDMYGPRVCGIIGSCLLF
LASGNFISAKHLVSLWDPYLVGYTLLAVAGPFVFISCFQLANSFPQRSGTVLALLTGS
FDSSSALFLLYRLLYQNWFPTLNVSRFFTLYLIVPVFILACQLTIMPHSSYKTVNHIA
KIAVEGLDENGRLIEGDTGSGIIPDEQERQSLIAIEREEDSIPSRPQRRKSVLETYVE
DKLQKKSGGIFGVLHGKSAYEQIKSPWFYLMLLFALVAMLRINYFIATVRTQEEYLLN
DPDLALKLNSIFDMLLPLGGAVSIPFIGLLLDHTDTLSTLTILFTTSTAIGVFGLIPN
SFTWNLIGIVLLVVYRPFYYTVVSDYSSKVFGFDTFGTVYGLLSCICGIFNMSQNLLD
KWTHTTFNMNPFPINLTLVILTVVFSLTLTFYIRSQILPKPVNERGLSSNYQTI"
gene complement(<715638..>716309)
/gene="FSH2"
/locus_tag="YMR222C"
/db_xref="GeneID:855262"
mRNA complement(<715638..>716309)
/gene="FSH2"
/locus_tag="YMR222C"
/product="putative serine hydrolase"
/transcript_id="NM_001182729.1"
/db_xref="GeneID:855262"
CDS complement(715638..716309)
/gene="FSH2"
/locus_tag="YMR222C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="Putative serine hydrolase that localizes to the
cytoplasm; sequence is similar to S. cerevisiae Fsh1p and
Fsh3p and the human candidate tumor suppressor OVCA2"
/codon_start=1
/product="putative serine hydrolase"
/protein_id="NP_013949.1"
/db_xref="GeneID:855262"
/db_xref="SGD:S000004835"
/translation="MTKNVLMLHGLAQSGDYFASKTKGFRAEMEKLGYKLYYPTAPNE
FPPADVPDFLGEVIADAPGDGENTGVLAWLENDPSTGGYFIPQTTIDYLHNYVLENGP
FAGIVGFSQGAGVAGYLATDFNGLLGLTTEEQPPLEFFMAVSGFRFQPQQYQEQYDLH
PISVPSLHVQGELDTITEPAKVQGLYNSCTEDSRTLLMHSGGHFVPNSRGFVRKVAQW
LQQLT"
gene <716715..>718130
/gene="UBP8"
/locus_tag="YMR223W"
/db_xref="GeneID:855263"
mRNA <716715..>718130
/gene="UBP8"
/locus_tag="YMR223W"
/product="ubiquitin-specific protease UBP8"
/transcript_id="NM_001182730.1"
/db_xref="GeneID:855263"
CDS 716715..718130
/gene="UBP8"
/locus_tag="YMR223W"
/EC_number="3.4.19.12"
/experiment="EXISTENCE:direct assay:GO:0000124 SAGA
complex [PMID:14563679|PMID:12052880]"
/experiment="EXISTENCE:direct assay:GO:0046695 SLIK
(SAGA-like) complex [PMID:14563679]"
/experiment="EXISTENCE:direct assay:GO:0060090 molecular
adaptor activity [PMID:20434206]"
/experiment="EXISTENCE:direct assay:GO:0071819 DUBm
complex [PMID:20395473]"
/experiment="EXISTENCE:mutant phenotype:GO:0004843
cysteine-type deubiquitinase activity [PMID:14563679]"
/experiment="EXISTENCE:mutant phenotype:GO:0008380 RNA
splicing [PMID:23209445]"
/experiment="EXISTENCE:mutant phenotype:GO:0060090
molecular adaptor activity [PMID:20434206]"
/note="Ubiquitin-specific protease component of the SAGA
acetylation complex; required for SAGA
(Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination
of histone H2B"
/codon_start=1
/product="ubiquitin-specific protease UBP8"
/protein_id="NP_013950.1"
/db_xref="GeneID:855263"
/db_xref="SGD:S000004836"
/translation="MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTM
KCGTCHEINSGATFMCLQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDY
IGNIDLINDAILAKYWDDVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPY
FIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIY
LLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVH
TVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNY
HCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYC
STKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSI
SQEEVLKEQAYLLFYTIRQVN"
gene complement(<718575..>720653)
/gene="MRE11"
/locus_tag="YMR224C"
/gene_synonym="NGS1; RAD58; XRS4"
/db_xref="GeneID:855264"
mRNA complement(<718575..>720653)
/gene="MRE11"
/locus_tag="YMR224C"
/gene_synonym="NGS1; RAD58; XRS4"
/product="MRX complex nuclease subunit"
/transcript_id="NM_001182731.1"
/db_xref="GeneID:855264"
CDS complement(718575..720653)
/gene="MRE11"
/locus_tag="YMR224C"
/gene_synonym="NGS1; RAD58; XRS4"
/experiment="EXISTENCE:direct assay:GO:0003691
double-stranded telomeric DNA binding [PMID:17698079]"
/experiment="EXISTENCE:direct assay:GO:0004017 adenylate
kinase activity [PMID:17349953]"
/experiment="EXISTENCE:direct assay:GO:0004519
endonuclease activity [PMID:9858579]"
/experiment="EXISTENCE:direct assay:GO:0004520 DNA
endonuclease activity [PMID:16116037]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:15548595|PMID:22842922|PMID:9845372]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0008408 3'-5'
exonuclease activity [PMID:11454871]"
/experiment="EXISTENCE:direct assay:GO:0042162 telomeric
DNA binding [PMID:15721260|PMID:16116037]"
/experiment="EXISTENCE:direct assay:GO:0043047
single-stranded telomeric DNA binding [PMID:17698079]"
/experiment="EXISTENCE:direct assay:GO:0051880
G-quadruplex DNA binding [PMID:17698079]"
/experiment="EXISTENCE:genetic interaction:GO:0000727
double-strand break repair via break-induced replication
[PMID:17321803]"
/experiment="EXISTENCE:genetic interaction:GO:0060090
molecular adaptor activity [PMID:9845372]"
/experiment="EXISTENCE:mutant phenotype:GO:0000723
telomere maintenance [PMID:9501103]"
/experiment="EXISTENCE:mutant phenotype:GO:0000727
double-strand break repair via break-induced replication
[PMID:17321803]"
/experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
repair [PMID:7789757]"
/experiment="EXISTENCE:mutant phenotype:GO:0006284
base-excision repair [PMID:20040573]"
/experiment="EXISTENCE:mutant phenotype:GO:0006303
double-strand break repair via nonhomologous end joining
[PMID:12399380|PMID:9501103]"
/experiment="EXISTENCE:mutant phenotype:GO:0007131
reciprocal meiotic recombination [PMID:8417989]"
/experiment="EXISTENCE:mutant phenotype:GO:0010791 DNA
double-strand break processing involved in repair via
synthesis-dependent strand annealing [PMID:23254329]"
/experiment="EXISTENCE:mutant phenotype:GO:0030437
ascospore formation [PMID:17396017]"
/experiment="EXISTENCE:mutant phenotype:GO:0035753
maintenance of DNA trinucleotide repeats [PMID:27173583]"
/experiment="EXISTENCE:mutant phenotype:GO:0051037
regulation of transcription involved in meiotic cell cycle
[PMID:17396017]"
/experiment="EXISTENCE:mutant phenotype:GO:0060090
molecular adaptor activity [PMID:9845372]"
/experiment="EXISTENCE:mutant phenotype:GO:0097552
mitochondrial double-strand break repair via homologous
recombination [PMID:22214610]"
/experiment="EXISTENCE:physical interaction:GO:0030870
Mre11 complex [PMID:9845372]"
/note="Nuclease subunit of the MRX complex with Rad50p and
Xrs2p; complex functions in repair of DNA double-strand
breaks and in telomere stability; Mre11p associates with
Ser/Thr-rich ORFs in premeiotic phase; nuclease activity
required for MRX function; widely conserved; forms nuclear
foci upon DNA replication stress"
/codon_start=1
/product="MRX complex nuclease subunit"
/protein_id="NP_013951.1"
/db_xref="GeneID:855264"
/db_xref="SGD:S000004837"
/translation="MDYPDPDTIRILITTDNHVGYNENDPITGDDSWKTFHEVMMLAK
NNNVDMVVQSGDLFHVNKPSKKSLYQVLKTLRLCCMGDKPCELELLSDPSQVFHYDEF
TNVNYEDPNFNISIPVFGISGNHDDASGDSLLCPMDILHATGLINHFGKVIESDKIKV
VPLLFQKGSTKLALYGLAAVRDERLFRTFKDGGVTFEVPTMREGEWFNLMCVHQNHTG
HTNTAFLPEQFLPDFLDMVIWGHEHECIPNLVHNPIKNFDVLQPGSSVATSLCEAEAQ
PKYVFILDIKYGEAPKMTPIPLETIRTFKMKSISLQDVPHLRPHDKDATSKYLIEQVE
EMIRDANEETKQKLADDGEGDMVAELPKPLIRLRVDYSAPSNTQSPIDYQVENPRRFS
NRFVGRVANGNNVVQFYKKRSPVTRSKKSGINGTSISDRDVEKLFSESGGELEVQTLV
NDLLNKMQLSLLPEVGLNEAVKKFVDKDEKTALKEFISHEISNEVGILSTNEEFLRTD
DAEEMKALIKQVKRANSVRPTPPKENDETNFAFNGNGLDSFRSSNREVRTGSPDITQS
HVDNESRITHISQAESSKPTSKPKRVRTATKKKIPAFSDSTVISDAENELGDNNDAQD
DVDIDENDIIMVSTDEEDASYGLLNGRKTKTKTRPAASTKTASRRGKGRASRTPKTDI
LGSLLAKKRK"
gene complement(<720960..>721403)
/gene="MRPL44"
/locus_tag="YMR225C"
/gene_synonym="mL53; YMR44"
/db_xref="GeneID:855265"
mRNA complement(join(<720960..721198,721346..>721403))
/gene="MRPL44"
/locus_tag="YMR225C"
/gene_synonym="mL53; YMR44"
/product="mitochondrial 54S ribosomal protein YmL44"
/transcript_id="NM_001182732.1"
/db_xref="GeneID:855265"
CDS complement(join(720960..721198,721346..721403))
/gene="MRPL44"
/locus_tag="YMR225C"
/gene_synonym="mL53; YMR44"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:2060626]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:2060626]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005762
mitochondrial large ribosomal subunit [PMID:2060626]"
/note="Mitochondrial ribosomal protein of the large
subunit; protein abundance increases in response to DNA
replication stress"
/codon_start=1
/product="mitochondrial 54S ribosomal protein YmL44"
/protein_id="NP_013952.1"
/db_xref="GeneID:855265"
/db_xref="SGD:S000004838"
/translation="MITKYFSKVIVRFNPFGKEAKVARLVLAAIPPTQRNMGTQIQSE
IISDYNKVKPLVKVTYKDKKEMEVDPSNMNFQELANHFDRHSKQLDLKHMLEMH"
gene complement(<721593..>722396)
/gene="ORA1"
/locus_tag="YMR226C"
/db_xref="GeneID:855266"
mRNA complement(<721593..>722396)
/gene="ORA1"
/locus_tag="YMR226C"
/product="oxidoreductase"
/transcript_id="NM_001182733.1"
/db_xref="GeneID:855266"
CDS complement(721593..722396)
/gene="ORA1"
/locus_tag="YMR226C"
/EC_number="1.1.1.381"
/experiment="EXISTENCE:direct assay:GO:0004090 carbonyl
reductase (NADPH) activity [PMID:18630881]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0016491
oxidoreductase activity [PMID:17962934]"
/experiment="EXISTENCE:direct assay:GO:0031132 serine
3-dehydrogenase activity [PMID:12535615]"
/experiment="EXISTENCE:direct assay:GO:0045149 acetoin
metabolic process [PMID:33845171]"
/experiment="EXISTENCE:direct assay:GO:0052588 diacetyl
reductase ((S)-acetoin forming) activity [PMID:33845171]"
/note="NADP(+)-dependent serine dehydrogenase and carbonyl
reductase; acts on serine, L-allo-threonine, and other
3-hydroxy acids; catalyzes the reduction of
(S)-alpha-acetolactate to 2,3-dimethylglycerate;
short-chain dehydrogenase/reductase (SDR) family member;
GFP fusion protein localizes to the cytoplasm and nucleus"
/codon_start=1
/product="oxidoreductase"
/protein_id="NP_013953.1"
/db_xref="GeneID:855266"
/db_xref="SGD:S000004839"
/translation="MSQGRKAAERLAKKTVLITGASAGIGKATALEYLEASNGDMKLI
LAARRLEKLEELKKTIDQEFPNAKVHVAQLDITQAEKIKPFIENLPQEFKDIDILVNN
AGKALGSDRVGQIATEDIQDVFDTNVTALINITQAVLPIFQAKNSGDIVNLGSIAGRD
AYPTGSIYCASKFAVGAFTDSLRKELINTKIRVILIAPGLVETEFSLVRYRGNEEQAK
NVYKDTTPLMADDVADLIVYATSRKQNTVIADTLIFPTNQASPHHIFRG"
gene complement(<722613..>724385)
/gene="TAF7"
/locus_tag="YMR227C"
/gene_synonym="TAF67"
/db_xref="GeneID:855267"
mRNA complement(<722613..>724385)
/gene="TAF7"
/locus_tag="YMR227C"
/gene_synonym="TAF67"
/product="TATA-binding protein-associated factor TAF7"
/transcript_id="NM_001182734.1"
/db_xref="GeneID:855267"
CDS complement(722613..724385)
/gene="TAF7"
/locus_tag="YMR227C"
/gene_synonym="TAF67"
/experiment="EXISTENCE:curator inference:GO:0016251 RNA
polymerase II general transcription initiation factor
activity []"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005669
transcription factor TFIID complex
[PMID:10788514|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0006366
transcription by RNA polymerase II
[PMID:12138208|PMID:15448131]"
/experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
polymerase II preinitiation complex assembly
[PMID:12840001]"
/note="TFIID subunit (67 kDa); involved in RNA polymerase
II transcription initiation"
/codon_start=1
/product="TATA-binding protein-associated factor TAF7"
/protein_id="NP_013954.1"
/db_xref="GeneID:855267"
/db_xref="SGD:S000004840"
/translation="MAVIRIKKPRGPGEKDQPLEGEPKLKRIRIKTKVTDEDIKPKPK
LKINLKKKKESADGKEKKNSLKLKLNLKKNEEPVKKIHKAPKLRLKPIRIPGEAYDSE
ASDIEDDPLIESGVILRILPDIQLEFVKNSLESGDYSGISIKWKNERHAVVTINDVMY
GAILVDLPTVIEVNKSVDRKNLLKTFDVSQMLLCIRPIQEEEEVYALEAPDTEDLVVK
HFEGIEDEIWENKETFLKGYNGAPLSDMEAKHLKEIALKGYDYKHGISPPLYNVRNRR
FRRKMDPNEIDYVEKVVDMLLKQDKQAEEVSYDLVDKSELQARQERVSSWENFKEEPG
EPLSRPALKKEEIHTIASAVGKQGAEEEGEEGMEEEEEEDLDLGAAFESEEEGSGAEG
DKEQQQEEVGDEVDQDTGGEDDDDDDDGDIEAAGGESESDDEKDENRQHTELLADELN
ELETTLAHTKHKLSKATNPLLKSRFIDSIKKLEKEAELKRKQLQQTEDSVQKQHQHRS
DAETANNVEEEEEEEEEEEEEDEVDEDEEDDEENDEDEDNVHEREHIQENKVVRELDE
APAEETLDQNDLDMMMLFGAEGDE"
gene <724626..>725651
/gene="MTF1"
/locus_tag="YMR228W"
/db_xref="GeneID:855268"
mRNA <724626..>725651
/gene="MTF1"
/locus_tag="YMR228W"
/product="RNA polymerase specificity factor"
/transcript_id="NM_001182735.1"
/db_xref="GeneID:855268"
CDS 724626..725651
/gene="MTF1"
/locus_tag="YMR228W"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005758
mitochondrial intermembrane space
[PMID:12270918|PMID:22984289]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:12270918]"
/experiment="EXISTENCE:direct assay:GO:0006391
transcription initiation at mitochondrial promoter
[PMID:19920143]"
/experiment="EXISTENCE:direct assay:GO:0034245
mitochondrial DNA-directed RNA polymerase complex
[PMID:7929382]"
/experiment="EXISTENCE:direct assay:GO:0034246
mitochondrial transcription factor activity
[PMID:20008320|PMID:7929382]"
/experiment="EXISTENCE:mutant phenotype:GO:0032786
positive regulation of DNA-templated transcription,
elongation [PMID:31980825]"
/experiment="EXISTENCE:physical interaction:GO:0034246
mitochondrial transcription factor activity
[PMID:7929382]"
/note="Mitochondrial RNA polymerase specificity factor;
has structural similarity to
S-adenosylmethionine-dependent methyltransferases and
functional similarity to bacterial sigma-factors; Mtf1p
interacts with and stabilizes the Rpo41p-promoter complex,
enhancing DNA bending and melting to facilitate
pre-initiation open complex formation"
/codon_start=1
/product="RNA polymerase specificity factor"
/protein_id="NP_013955.1"
/db_xref="GeneID:855268"
/db_xref="SGD:S000004841"
/translation="MSVPIPGIKDISKLKFFYGFKYLWNPTVYNKIFDKLDLTKTYKH
PEELKVLDLYPGVGIQSAIFYNKYCPRQYSLLEKRSSLYKFLNAKFEGSPLQILKRDP
YDWSTYSNLIDEERIFVPEVQSSDHINDKFLTVANVTGEGSEGLIMQWLSCIGNKNWL
YRFGKVKMLLWMPSTTARKLLARPGMHSRSKCSVVREAFTDTKLIAISDANELKGFDS
QCIEEWDPILFSAAEIWPTKGKPIALVEMDPIDFDFDVDNWDYVTRHLMILKRTPLNT
VMDSLGHGGQQYFNSRITDKDLLKKCPIDLTNDEFIYLTKLFMEWPFKPDILMDFVDM
YQTEHSG"
gene complement(<725934..>731123)
/gene="RRP5"
/locus_tag="YMR229C"
/db_xref="GeneID:855269"
mRNA complement(<725934..>731123)
/gene="RRP5"
/locus_tag="YMR229C"
/product="Rrp5p"
/transcript_id="NM_001182736.1"
/db_xref="GeneID:855269"
CDS complement(725934..731123)
/gene="RRP5"
/locus_tag="YMR229C"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:22842922|PMID:8896463]"
/experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA
binding [PMID:16428605]"
/experiment="EXISTENCE:direct assay:GO:0030490 maturation
of SSU-rRNA [PMID:23630256]"
/experiment="EXISTENCE:direct assay:GO:0030515 snoRNA
binding [PMID:24239293]"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:12150911]"
/experiment="EXISTENCE:direct assay:GO:0032040
small-subunit processome [PMID:12068309]"
/experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA
binding [PMID:24239293]"
/experiment="EXISTENCE:direct assay:GO:0034512 box C/D RNA
binding [PMID:24239293]"
/experiment="EXISTENCE:direct assay:GO:0034513 box H/ACA
snoRNA binding [PMID:24239293]"
/experiment="EXISTENCE:direct assay:GO:0042134 rRNA
primary transcript binding [PMID:24239293]"
/experiment="EXISTENCE:mutant phenotype:GO:0000447
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from
5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8896463]"
/experiment="EXISTENCE:mutant phenotype:GO:0000464
endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA
from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA,
LSU-rRNA) [PMID:8896463]"
/experiment="EXISTENCE:mutant phenotype:GO:0000472
endonucleolytic cleavage to generate mature 5'-end of
SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
[PMID:8896463]"
/experiment="EXISTENCE:mutant phenotype:GO:0000480
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA
transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8896463]"
/experiment="EXISTENCE:mutant phenotype:GO:0034463 90S
preribosome assembly [PMID:24239293]"
/note="RNA binding protein involved in synthesis of 18S
and 5.8S rRNAs; component of ribosomal small subunit (SSU)
processome and 90S preribosome; required for pre-rRNA
packaging and compaction of processome into dense terminal
balls; part of Mak21p-Noc2p-Rrp5p module that associates
with nascent pre-rRNA during transcription with role in
biogenesis of large ribosomal subunit; binds single
stranded tracts of U's; relocalizes from nucleolus to
nucleus upon DNA replication stress"
/codon_start=1
/product="Rrp5p"
/protein_id="NP_013956.1"
/db_xref="GeneID:855269"
/db_xref="SGD:S000004842"
/translation="MVASTKRKRDEDFPLSREDSTKQPSTSSLVRNTEEVSFPRGGAS
ALTPLELKQVANEAASDVLFGNESVKASEPASRPLKKKKTTKKSTSKDSEASSANSDE
ARAGLIEHVNFKTLKNGSSLLGQISAITKQDLCITFTDGISGYVNLTHISEEFTSILE
DLDEDMDSDTDAADEKKSKVEDAEYESSDDEDEKLDKSNELPNLRRYFHIGQWLRCSV
IKNTSLEPSTKKSKKKRIELTIEPSSVNIYADEDLVKSTSIQCAVKSIEDHGATLDVG
LPGFTGFIAKKDFGNFEKLLPGAVFLGNITKKSDRSIVVNTDFSDKKNKITQISSIDA
IIPGQIVDLLCESITKNGIAGKVFGLVSGVVNVSHLRTFSEEDLKHKFVIGSSIRCRI
IACLENKSGDKVLILSNLPHILKLEDALRSTEGLDAFPIGYTFESCSIKGRDSEYLYL
ALDDDRLGKVHSSRVGEIENSENLSSRVLGYSPVDDIYQLSTDPKYLKLKYLRTNDIP
IGELLPSCEITSVSSSGIELKIFNGQFKASVPPLHISDTRLVYPERKFKIGSKVKGRV
ISVNSRGNVHVTLKKSLVNIEDNELPLVSTYENAKNIKEKNEKTLATIQVFKPNGCII
SFFGGLSGFLPNSEISEVFVKRPEEHLRLGQTVIVKLLDVDADRRRIIATCKVSNEQA
AQQKDTIENIVPGRTIITVHVIEKTKDSVIVEIPDVGLRGVIYVGHLSDSRIEQNRAQ
LKKLRIGTELTGLVIDKDTRTRVFNMSLKSSLIKDAKKETLPLTYDDVKDLNKDVPMH
AYIKSISDKGLFVAFNGKFIGLVLPSYAVDSRDIDISKAFYINQSVTVYLLRTDDKNQ
KFLLSLKAPKVKEEKKKVESNIEDPVDSSIKSWDDLSIGSIVKAKIKSVKKNQLNVIL
AANLHGRVDIAEVFDTYEEITDKKQPLSNYKKDDVIKVKIIGNHDVKSHKFLPITHKI
SKASVLELSMKPSELKSKEVHTKSLEEINIGQELTGFVNNSSGNHLWLTISPVLKARI
SLLDLADNDSNFSENIESVFPLGSALQVKVASIDREHGFVNAIGKSHVDINMSTIKVG
DELPGRVLKIAEKYVLLDLGNKVTGISFITDALNDFSLTLKEAFEDKINNVIPTTVLS
VDEQNKKIELSLRPATAKTRSIKSHEDLKQGEIVDGIVKNVNDKGIFVYLSRKVEAFV
PVSKLSDSYLKEWKKFYKPMQYVLGKVVTCDEDSRISLTLRESEINGDLKVLKTYSDI
KAGDVFEGTIKSVTDFGVFVKLDNTVNVTGLAHITEIADKKPEDLSALFGVGDRVKAI
VLKTNPEKKQISLSLKASHFSKEAELASTTTTTTTVDQLEKEDEDEVMADAGFNDSDS
ESDIGDQNTEVADRKPETSSDGLSLSAGFDWTASILDQAQEEEESDQDQEDFTENKKH
KHKRRKENVVQDKTIDINTRAPESVADFERLLIGNPNSSVVWMNYMAFQLQLSEIEKA
RELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTK
LLGIYEISEKFDKAAELFKATAKKFGGEKVSIWVSWGDFLISHNEEQEARTILGNALK
ALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDK
KKVEDLFERIITKKITRKQAKFFFNKWLQFEESEGDEKTIEYVKAKATEYVASHESQK
ADE"
gene <732414..>733141
/gene="RPS10B"
/locus_tag="YMR230W"
/db_xref="GeneID:855270"
mRNA join(<732414..732465,732876..>733141)
/gene="RPS10B"
/locus_tag="YMR230W"
/product="ribosomal 40S subunit protein S10B"
/transcript_id="NM_001182737.1"
/db_xref="GeneID:855270"
CDS join(732414..732465,732876..733141)
/gene="RPS10B"
/locus_tag="YMR230W"
/experiment="EXISTENCE:genetic interaction:GO:0006407 rRNA
export from nucleus [PMID:16246728]"
/note="Protein component of the small (40S) ribosomal
subunit; homologous to mammalian ribosomal protein S10, no
bacterial homolog; RPS10B has a paralog, RPS10A, that
arose from the whole genome duplication; mutations in the
human homolog associated with Diamond-Blackfan anemia"
/codon_start=1
/product="ribosomal 40S subunit protein S10B"
/protein_id="NP_013957.1"
/db_xref="GeneID:855270"
/db_xref="SGD:S000004843"
/translation="MLMPKQERNKIHQYLFQEGVVVAKKDFNQAKHEEIDTKNLYVIK
ALQSLTSKGYVKTQFSWQYYYYTLTEEGVEYLREYLNLPEHIVPGTYIQERNPSQRPQ
RRY"
gene <733268..>733456
/locus_tag="YMR230W-A"
/db_xref="GeneID:1466504"
mRNA <733268..>733456
/locus_tag="YMR230W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184573.1"
/db_xref="GeneID:1466504"
CDS 733268..733456
/locus_tag="YMR230W-A"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878146.1"
/db_xref="GeneID:1466504"
/db_xref="SGD:S000028576"
/translation="MCIIVKYSQCNLFFQDVLRCRHVLCMLFSIVVHFRLSSFVSVCG
VRIMCNCINCSRFIHNIN"
gene <733545..>736634
/gene="PEP5"
/locus_tag="YMR231W"
/gene_synonym="END1; VAM1; VPL9; VPS11; VPT11"
/db_xref="GeneID:855271"
mRNA <733545..>736634
/gene="PEP5"
/locus_tag="YMR231W"
/gene_synonym="END1; VAM1; VPL9; VPS11; VPT11"
/product="tethering complex subunit PEP5"
/transcript_id="NM_001182738.1"
/db_xref="GeneID:855271"
CDS 733545..736634
/gene="PEP5"
/locus_tag="YMR231W"
/gene_synonym="END1; VAM1; VPL9; VPS11; VPT11"
/EC_number="2.3.2.27"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:10944212]"
/experiment="EXISTENCE:direct assay:GO:0033263 CORVET
complex [PMID:17488625]"
/experiment="EXISTENCE:direct assay:GO:0035091
phosphatidylinositol binding [PMID:16601699]"
/experiment="EXISTENCE:direct assay:GO:0035542 regulation
of SNARE complex assembly [PMID:18385512]"
/experiment="EXISTENCE:direct assay:GO:0042144 vacuole
fusion, non-autophagic [PMID:10944212]"
/experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin
protein ligase activity [PMID:22570702]"
/experiment="EXISTENCE:direct assay:GO:0099022 vesicle
tethering [PMID:27307091]"
/experiment="EXISTENCE:genetic interaction:GO:0006895
Golgi to endosome transport [PMID:11422941]"
/experiment="EXISTENCE:genetic interaction:GO:0045324 late
endosome to vacuole transport [PMID:11422941]"
/experiment="EXISTENCE:mutant phenotype:GO:0036205 histone
catabolic process [PMID:22570702]"
/experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole
fusion, non-autophagic [PMID:10944212]"
/experiment="EXISTENCE:physical interaction:GO:0030897
HOPS complex [PMID:10944212]"
/note="Histone E3 ligase, component of CORVET membrane
tethering complex; peripheral vacuolar membrane protein
required for protein trafficking and vacuole biogenesis;
interacts with Pep7p; involved in ubiquitination and
degradation of excess histones"
/codon_start=1
/product="tethering complex subunit PEP5"
/protein_id="NP_013958.1"
/db_xref="GeneID:855271"
/db_xref="SGD:S000004844"
/translation="MSLSSWRQFQLFENIPIRDPNFGGDSLLYSDPTLCAATIVDPQT
LIIAVNSNIIKVVKLNQSQVIHEFQSFPHDFQITFLKVINGEFLVALAESIGKPSLIR
VYKLEKLPNREQLYHSQVELKNGNNTYPISVVSISNDLSCIVVGFINGKIILIRGDIS
RDRGSQQRIIYEDPSKEPITALFLNNDATACFAATTSRILLFNTTGRNRGRPSLVLNS
KNGLDLNCGSFNPATNEFICCLSNFIEFFSSSGKKHQFAFDLSLRKRIFCVDKDHILI
VTEETGVPTTSISVNELSPTIINRIFIIDAKNKIISLNFVVSSAIIDIFSTSQSGKNI
TYLLTSEGVMHRITPKSLENQINIIIQKELYPFALQLAKQHSLSPLDVQEIHKKYGDY
LFKKGLRKEATDQYIQCLDVVETSEIISKFGVKEVPDPESMRNLADYLWSLIKNSISQ
RDHVTLLLIVLIKLKDVEGIDTFIQHFDRKGIWNEGVVMDDMDDVTFFYSDNDFFDLD
LILELMKESDFKRLSYRLAKKYSKDSLIIVDILLNLLHNPVKAIKYIKSLPIDETLRC
LVTYSKKLLEESPNETNALLIEVFTGKFKPSTFEVDLDRRDTTGDFSENIRTVFYSYK
TFFNYMNSNGTSDAMSESSEASHEHEEPTYHPPKPSIVFSSFVTKPFEFVVFLEACLA
CYQQYEGFDEDRQVILTTLYDLYLNLAQNDVPERIDDWRSRATGVLRESNKLVYSAAS
NNTSKRVDNSIMLLISHMDQSSASAKDKTKIDIASFANDNPEMDLLSTFRAMTLNEEP
STCLKFLEKYGTEEPKLLQVALSYFVSNKLIFKEMGGNEVLKEKVLRPIIEGERMPLL
DIIKALSRTNVAHFGLIQDIIIDHVKTEDTEIKRNEKLIESYDKELKEKNKKLKNTIN
SDQPLHVPLKNQTCFMCRLTLDIPVVFFKCGHIYHQHCLNEEEDTLESERKLFKCPKC
LVDLETSNKLFEAQHEVVEKNDLLNFALNSEEGSRDRFKVITEFLGRGAISYSDITI"
gene <736926..>738959
/gene="FUS2"
/locus_tag="YMR232W"
/db_xref="GeneID:855272"
mRNA <736926..>738959
/gene="FUS2"
/locus_tag="YMR232W"
/product="Fus2p"
/transcript_id="NM_001182739.1"
/db_xref="GeneID:855272"
CDS 736926..738959
/gene="FUS2"
/locus_tag="YMR232W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:18474625|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:18474625]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0043332 mating
projection tip [PMID:7559752]"
/experiment="EXISTENCE:genetic interaction:GO:0000755
cytogamy [PMID:3302672]"
/experiment="EXISTENCE:mutant phenotype:GO:0000742
karyogamy involved in conjugation with cellular fusion
[PMID:7559752]"
/experiment="EXISTENCE:mutant phenotype:GO:0000747
conjugation with cellular fusion [PMID:22323294]"
/experiment="EXISTENCE:mutant phenotype:GO:0000755
cytogamy [PMID:3302672|PMID:7559752]"
/note="Cell fusion regulator; cytoplasmic protein
localized to shmoo tip; required for alignment of parental
nuclei before nuclear fusion during mating; contains a
Dbl-homology domain; binds specifically with activated
Cdc42p"
/codon_start=1
/product="Fus2p"
/protein_id="NP_013959.1"
/db_xref="GeneID:855272"
/db_xref="SGD:S000004845"
/translation="MFKTSYNLYDLNYPKNDSLTPIRDYKNDYFHKNDDKLPEIVRKP
TRKLSKHENKLNDKKFTNKRPASLDLHSIVESLSNKKIYSPINTEIFQNVVRLNLSPQ
IPNSPHEGCKFYKIVQEFYLSEVEYYNNLLTANNVYRKALNSDPRFKNKLVKLDSSDE
LLLFGNIDTIASISKILVTAIKDLLLAKQRGKMLDANEWQKIFTKNEVQQQLYSTFDI
SEAFEQHLLRIKSTYTSYFVSHQKQMELFTTLRMNKNHFFNKWYEYCLKESGCIKLED
ILKSPMKRLTQWIDTLETLESCYEDILSPELGLKLSPTRRKYSLFSNKLETEVSEYKS
NSMYNFSLTPSEIIQSYDEDQFTHLLKPPDKQNKNICNASRQESNLDNSRVPSLLSGS
SSYYSDVSGLEIVTNTSTASAEMINLKMDEETEFFTLADHISKFKKVMKGLLELKKNL
LKNDLSGIIDISLRRINAWKKVIECERPSGAFFAHDNLISTMCSSYIDKLHEQKNQVT
ILKLTELETDVMNPLERIIAHCTTVKSKLKDLQALKKDYMLFLQEKKANVRDIKRDLL
GMHFQNLQNQMKRELPVFITLIHDTIECILLNYIKVFLKYLEIIAGGKKYLQKDLENM
SLNDSIATGQIKNLDILQCYSKSRYMTKRMVRKDWPFPGDPSGSRVVRKLFEL"
gene <739185..>739865
/gene="TRI1"
/locus_tag="YMR233W"
/db_xref="GeneID:855273"
mRNA <739185..>739865
/gene="TRI1"
/locus_tag="YMR233W"
/product="Tri1p"
/transcript_id="NM_001182740.1"
/db_xref="GeneID:855273"
CDS 739185..739865
/gene="TRI1"
/locus_tag="YMR233W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="Non-essential sumoylated hypothetical protein;
similar to components of human SWI/SNF complex including
SMRD3; green fluorescent protein (GFP)-fusion protein
localizes to the cytoplasm, nucleus and nucleolus; TRI1
has a paralog, UAF30, that arose from the whole genome
duplication"
/codon_start=1
/product="Tri1p"
/protein_id="NP_013960.1"
/db_xref="GeneID:855273"
/db_xref="SGD:S000004846"
/translation="MADINKYIPMVDAILSVSNPDEISPKRVRKALQILYSVNLDSQR
KLINELILERFGDIQENPRVLIPKNDLISRDQELSLRLQKEEERPLRSTRKRKGKSES
KSKRKKKKNDSPDSNSISVRKVLLSAPLQKFLGSEELPRTQVVKMIWQYIKEHDLQNP
KDRREILCDEKMEPIFGKKMTMFSMNKLLTKHLFNPDEIVKHEEEQKQTPEKEIKLEN
ESLPNLSG"
gene <740266..>741312
/gene="RNH1"
/locus_tag="YMR234W"
/db_xref="GeneID:855274"
mRNA <740266..>741312
/gene="RNH1"
/locus_tag="YMR234W"
/product="RNA-DNA hybrid ribonuclease"
/transcript_id="NM_001182741.1"
/db_xref="GeneID:855274"
CDS 740266..741312
/gene="RNH1"
/locus_tag="YMR234W"
/EC_number="3.1.26.4"
/experiment="EXISTENCE:direct assay:GO:0004523 RNA-DNA
hybrid ribonuclease activity [PMID:7489497]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006401 RNA
catabolic process [PMID:7489497]"
/note="Ribonuclease H1; able to bind double-stranded RNAs
and RNA-DNA hybrids; associates with RNAse polymerase I."
/codon_start=1
/product="RNA-DNA hybrid ribonuclease"
/protein_id="NP_013961.1"
/db_xref="GeneID:855274"
/db_xref="SGD:S000004847"
/translation="MARQGNFYAVRKGRETGIYNTWNECKNQVDGYGGAIYKKFNSYE
QAKSFLGQPNTTSNYGSSTHAGGQVSKPHTTQKRVHRRNRPLHYSSLTSSSACSSLSS
ANTNTFYSVKSNVPNIESKIFNNWKDCQAYVKHKRGITFKKFEDQLAAENFISGMSAH
DYKLMNISKESFESKYKLSSNTMYNKSMNVYCDGSSFGNGTSSSRAGYGAYFEGAPEE
NISEPLLSGAQTNNRAEIEAVSEALKKIWEKLTNEKEKVNYQIKTDSEYVTKLLNDRY
MTYDNKKLEGLPNSDLIVPLVQRFVKVKKYYELNKECFKNNGKFQIEWVKGHDGDPGN
EMADFLAKKGASRR"
gene complement(<741512..>742735)
/gene="RNA1"
/locus_tag="YMR235C"
/db_xref="GeneID:855275"
mRNA complement(<741512..>742735)
/gene="RNA1"
/locus_tag="YMR235C"
/product="GTPase-activating protein RNA1"
/transcript_id="NM_001182742.1"
/db_xref="GeneID:855275"
CDS complement(741512..742735)
/gene="RNA1"
/locus_tag="YMR235C"
/experiment="EXISTENCE:direct assay:GO:0005096 GTPase
activator activity
[PMID:9305944|PMID:7657689|PMID:7744835]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:8755533]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:2116418|PMID:8755533]"
/experiment="EXISTENCE:direct assay:GO:0006606 protein
import into nucleus [PMID:7657689]"
/experiment="EXISTENCE:direct assay:GO:0031267 small
GTPase binding [PMID:9305944]"
/experiment="EXISTENCE:genetic interaction:GO:0006409 tRNA
export from nucleus [PMID:22008473]"
/experiment="EXISTENCE:mutant phenotype:GO:0000054
ribosomal subunit export from nucleus [PMID:11739405]"
/experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase
activator activity [PMID:7657689]"
/experiment="EXISTENCE:mutant phenotype:GO:0006404 RNA
import into nucleus [PMID:16040803]"
/experiment="EXISTENCE:mutant phenotype:GO:0006407 rRNA
export from nucleus [PMID:11739405]"
/experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA
export from nucleus [PMID:22008473]"
/experiment="EXISTENCE:mutant phenotype:GO:0031509
subtelomeric heterochromatin formation [PMID:17904525]"
/note="GTPase activating protein (GAP) for Gsp1p; involved
in nuclear transport"
/codon_start=1
/product="GTPase-activating protein RNA1"
/protein_id="NP_013962.1"
/db_xref="GeneID:855275"
/db_xref="SGD:S000004848"
/translation="MATLHFVPQHEEEQVYSISGKALKLTTSDDIKPYLEELAALKTC
TKLDLSGNTIGTEASEALAKCIAENTQVRESLVEVNFADLYTSRLVDEVVDSLKFLLP
VLLKCPHLEIVNLSDNAFGLRTIELLEDYIAHAVNIKHLILSNNGMGPFAGERIGKAL
FHLAQNKKAASKPFLETFICGRNRLENGSAVYLALGLKSHSEGLKVVKLYQNGIRPKG
VATLIHYGLQYLKNLEILDLQDNTFTKHASLILAKALPTWKDSLFELNLNDCLLKTAG
SDEVFKVFTEVKFPNLHVLKFEYNEMAQETIEVSFLPAMEKGNLPELEKLEINGNRLD
EDSDALDLLQSKFDDLEVDDFEEVDSEDEEGEDEEDEDEDEKLEEIETERLEKELLEV
QVDDLAERLAETEIK"
gene <742971..>743444
/gene="TAF9"
/locus_tag="YMR236W"
/gene_synonym="TAF17"
/db_xref="GeneID:855276"
mRNA <742971..>743444
/gene="TAF9"
/locus_tag="YMR236W"
/gene_synonym="TAF17"
/product="chromatin modification protein"
/transcript_id="NM_001182743.1"
/db_xref="GeneID:855276"
CDS 742971..743444
/gene="TAF9"
/locus_tag="YMR236W"
/gene_synonym="TAF17"
/experiment="EXISTENCE:direct assay:GO:0000124 SAGA
complex [PMID:9674426]"
/experiment="EXISTENCE:direct assay:GO:0003682 chromatin
binding [PMID:10818000]"
/experiment="EXISTENCE:direct assay:GO:0005669
transcription factor TFIID complex
[PMID:10788514|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0006325 chromatin
organization [PMID:9674426]"
/experiment="EXISTENCE:direct assay:GO:0006366
transcription by RNA polymerase II
[PMID:12138208|PMID:15448131]"
/experiment="EXISTENCE:direct assay:GO:0046695 SLIK
(SAGA-like) complex [PMID:12446794]"
/experiment="EXISTENCE:mutant phenotype:GO:0006366
transcription by RNA polymerase II [PMID:10747053]"
/experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
polymerase II preinitiation complex assembly
[PMID:12840001]"
/experiment="EXISTENCE:mutant phenotype:GO:0060090
molecular adaptor activity [PMID:9844639]"
/note="Subunit (17 kDa) of TFIID and SAGA complexes;
involved in RNA polymerase II transcription initiation and
in chromatin modification, similar to histone H3"
/codon_start=1
/product="chromatin modification protein"
/protein_id="NP_013963.1"
/db_xref="GeneID:855276"
/db_xref="SGD:S000004849"
/translation="MNGGGKNVLNKNSVGSVSEVGPDSTQEETPRDVRLLHLLLASQS
IHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGSGNSAGSGLGVEDIRLAIAARTQ
YQFKPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDLEDPKSM"
gene <743749..>745923
/gene="BCH1"
/locus_tag="YMR237W"
/db_xref="GeneID:855277"
mRNA <743749..>745923
/gene="BCH1"
/locus_tag="YMR237W"
/product="exomer complex subunit"
/transcript_id="NM_001182744.1"
/db_xref="GeneID:855277"
CDS 743749..745923
/gene="BCH1"
/locus_tag="YMR237W"
/experiment="EXISTENCE:direct assay:GO:0030136
clathrin-coated vesicle [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0034044 exomer
complex [PMID:17000877]"
/experiment="EXISTENCE:genetic interaction:GO:0006893
Golgi to plasma membrane transport [PMID:16498409]"
/experiment="EXISTENCE:physical interaction:GO:0031267
small GTPase binding [PMID:16498409]"
/experiment="EXISTENCE:physical interaction:GO:0034221
fungal-type cell wall chitin biosynthetic process
[PMID:16498409]"
/note="Member of the ChAPs family (Chs5p-Arf1p-binding
proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p;
ChAPs family proteins form the exomer complex with Chs5p
to mediate export of specific cargo proteins from the
Golgi to the plasma membrane; interacts selectively with
the activated, GTP-bound form of Arf1p; may interact with
ribosomes; protein abundance increases and forms
cytoplasmic foci in response to DNA replication stress"
/codon_start=1
/product="exomer complex subunit"
/protein_id="NP_013964.1"
/db_xref="GeneID:855277"
/db_xref="SGD:S000004850"
/translation="MLSQTSIPEVKEDVIGYALHQRRARVGQFQDLGPPDLITLIKSL
PSSSSTTTATASANDNGATSNINGQDPTTIVTELHSHDKLKGQIGTFFYCMGIDTSDP
TSITIFAKKITDLFLDTPQIWFGKKKHFHVSKISISSWNAFRKYDVNIIVHIPGTVQT
YIINSDGEQSQLPSVAEASSGRNSQDLNVNMIWAETFMSGIVRDIMIMKDNRADGESQ
NLVETLIFNPFTSGELEDVANNFIKLFPLVYEKGVYLDAPTHVLNPSLTNNYLVETLV
EIVRLTKSLEACRKMLKKLIEIHPEAVIILIRVYFACDLEIDAVDLINEQLNSPSSFL
ADDSKTSHIQLIFKSELLSIQSEFLLDVKRDYKLAKEVAMEAVNCAPNEFKTWYLLTR
IYIKLNDMSNALLSLNACPMSQVKEKYVLRRIAPITSDENLHLPLPLDASIEEISSLN
PMDVQLEQKSADPNLVNLSASSLKSTFQLAYKLLTEIVQITGWEQLLKYRSKIFVMED
EYQGSTSSIDEAEVRGNDISKMRSKRLCERWLDNLFMLLYEDLKTYTDWQSEQLYFDA
QNSKYHKLTVEWELFGLCAKRLGHLPEAAKAFQIGLSQRFSPVCAKNLLQFYIDEHKR
IRRDSVSANSELTSSQILSSINDIDSSIIDLVVKICCWNHRWYIEFSIILIDALSVAV
QDMGITKVHNEIASRFSDPVAQLIDDNILNFLKNFTNDTFDN"
gene <746353..>747729
/gene="DFG5"
/locus_tag="YMR238W"
/db_xref="GeneID:855278"
mRNA <746353..>747729
/gene="DFG5"
/locus_tag="YMR238W"
/product="putative mannan endo-1,6-alpha-mannosidase"
/transcript_id="NM_001182745.1"
/db_xref="GeneID:855278"
CDS 746353..747729
/gene="DFG5"
/locus_tag="YMR238W"
/EC_number="3.2.1.101"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0009272 fungal-type
cell wall biogenesis [PMID:12421307]"
/experiment="EXISTENCE:genetic interaction:GO:0007117
budding cell bud growth [PMID:15470258]"
/experiment="EXISTENCE:mutant phenotype:GO:0007124
pseudohyphal growth [PMID:9055077]"
/note="Putative mannosidase; essential
glycosylphosphatidylinositol (GPI)-anchored membrane
protein required for cell wall biogenesis in bud
formation, involved in filamentous growth, homologous to
Dcw1p"
/codon_start=1
/product="putative mannan endo-1,6-alpha-mannosidase"
/protein_id="NP_013965.1"
/db_xref="GeneID:855278"
/db_xref="SGD:S000004851"
/translation="MIVNISAKMILSICFTFLSFFKATHAMDLDTTSKTSICDATALI
QGGMLDYYEGTRYGGTVGMFQSPYYWWHAGEAFGGMLENWFLCENDTYQELLYDALLA
QTGSNYDYIPSNQTMVEGNDDQGIWGITVMGAVERNFTDPGDGKPGWLAMVQAVFNTM
YSRWDSEHCGGGLRWQIFTWNSGYNYKNTVSNACLFQIAARLGRYTGNTTYLEVAEQV
FDWLVDVGYVVLNDTANVFDGAEIDTNCTDITKIEWTYNHGIVLGGLAYMYNATNGTG
EWETSLTKILNGAKSYFFKDSIMYESACQDYGTCNTDQRTFKSIFSRMLGLTSVMAPF
TRDTIDDLIKTSAEAAAKSCNGGTDGHTCGLNWQKQTNDGYYGLGEQMSALEVIQNLL
IHDRPAPYKEDNGGTSKGDANAGMNSSTTNVLQNNLNIKKGDRAGAAIITAVILSVLT
GGAVWMLF"
gene complement(747892..747963)
/locus_tag="YNCM0033C"
/db_xref="GeneID:855279"
tRNA complement(747892..747963)
/locus_tag="YNCM0033C"
/product="tRNA-Arg"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE
analysis; one of 11 nuclear tRNA genes containing the
tDNA-anticodon UCU (converted to mcm5-UCU in the mature
tRNA), decodes AGA codons into arginine, one of 19 nuclear
tRNAs for arginine"
/db_xref="GeneID:855279"
/db_xref="SGD:S000006717"
gene complement(<748262..>749677)
/gene="RNT1"
/locus_tag="YMR239C"
/db_xref="GeneID:855280"
mRNA complement(<748262..>749677)
/gene="RNT1"
/locus_tag="YMR239C"
/product="ribonuclease III"
/transcript_id="NM_001182746.1"
/db_xref="GeneID:855280"
CDS complement(748262..749677)
/gene="RNT1"
/locus_tag="YMR239C"
/EC_number="3.1.26.3"
/experiment="EXISTENCE:direct assay:GO:0004525
ribonuclease III activity [PMID:15766245]"
/experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm
[PMID:15090619]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:15090619]"
/experiment="EXISTENCE:direct assay:GO:0006379 mRNA
cleavage [PMID:17158880]"
/experiment="EXISTENCE:direct assay:GO:0030847 termination
of RNA polymerase II transcription, exosome-dependent
[PMID:19818713]"
/experiment="EXISTENCE:direct assay:GO:0034476 U5 snRNA
3'-end processing [PMID:9334335]"
/experiment="EXISTENCE:genetic interaction:GO:0060237
regulation of fungal-type cell wall organization
[PMID:22576366]"
/experiment="EXISTENCE:mutant phenotype:GO:0006325
chromatin organization [PMID:17991894]"
/experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA
processing [PMID:17991894]"
/experiment="EXISTENCE:mutant phenotype:GO:0006379 mRNA
cleavage [PMID:17158880]"
/experiment="EXISTENCE:mutant phenotype:GO:0009303 rRNA
transcription [PMID:17991894]"
/experiment="EXISTENCE:mutant phenotype:GO:0030847
termination of RNA polymerase II transcription,
exosome-dependent [PMID:19818713]"
/experiment="EXISTENCE:mutant phenotype:GO:0034473 U1
snRNA 3'-end processing [PMID:10508172]"
/experiment="EXISTENCE:mutant phenotype:GO:0034475 U4
snRNA 3'-end processing [PMID:10508172]"
/experiment="EXISTENCE:mutant phenotype:GO:0034476 U5
snRNA 3'-end processing [PMID:10508172|PMID:9334335]"
/experiment="EXISTENCE:mutant phenotype:GO:0034963 box C/D
RNA processing [PMID:23201338]"
/experiment="EXISTENCE:mutant phenotype:GO:0034964 box
H/ACA RNA processing [PMID:23201338]"
/experiment="EXISTENCE:mutant phenotype:GO:0060237
regulation of fungal-type cell wall organization
[PMID:22576366]"
/note="Nuclear dsRNA-specific ribonuclease (RNase III);
involved in rDNA transcription, rRNA processing and U2
snRNA 3' end formation by cleavage of a stem-loop
structure at the 3' end of U2 snRNA; involved in
polyadenylation-independent transcription termination;
involved in the cell wall stress response, regulating the
degradation of cell wall integrity and morphogenesis
checkpoint genes"
/codon_start=1
/product="ribonuclease III"
/protein_id="NP_013966.1"
/db_xref="GeneID:855280"
/db_xref="SGD:S000004852"
/translation="MGSKVAGKKKTQNDNKLDNENGSQQRENINTKTLLKGNLKISNY
KYLEVIQLEHAVTKLVESYNKIIELSPNLVAYNEAVNNQDRVPVQILPSLSRYQLKLA
AELKTLHDLKKDAILTEITDYENEFDTEQKQPILQEISKADMEKLEKLEQVKREKREK
IDVNVYENLNEKEDEEEDEGEDSYDPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHK
STIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLV
SNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNN
LPKIRKWLRKLAKPVIEEATRNQVALEKTDKLDMNAKRQLYSLIGYASLRLHYVTVKK
PTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPR
SESVLKDPSQKNKKRKFSDTS"
gene complement(<749930..>751240)
/gene="CUS1"
/locus_tag="YMR240C"
/db_xref="GeneID:855281"
mRNA complement(<749930..>751240)
/gene="CUS1"
/locus_tag="YMR240C"
/product="U2 snRNP complex subunit CUS1"
/transcript_id="NM_001182747.1"
/db_xref="GeneID:855281"
CDS complement(749930..751240)
/gene="CUS1"
/locus_tag="YMR240C"
/experiment="EXISTENCE:direct assay:GO:0000245
spliceosomal complex assembly [PMID:8566755]"
/experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP
[PMID:15565172|PMID:16314500]"
/experiment="EXISTENCE:direct assay:GO:0071004 U2-type
prespliceosome [PMID:16618970]"
/experiment="EXISTENCE:physical interaction:GO:0000398
mRNA splicing, via spliceosome [PMID:16314500]"
/note="Protein required for assembly of U2 snRNP into the
spliceosome; forms a complex with Hsh49p and Hsh155p"
/codon_start=1
/product="U2 snRNP complex subunit CUS1"
/protein_id="NP_013967.1"
/db_xref="GeneID:855281"
/db_xref="SGD:S000004853"
/translation="MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGV
TNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKEITKDEKNNHVVIVEKNPVMNRK
HTAEDELEDTPSDGIEEHLSARKRRKTEKPSLSQLKSQVPYPQIIEWYDCDARYPGLL
ASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLPQSGLD
GQDEKSLKEASRARVQPKMGALDLDYKKLHDVFFKIGANWKPDHLLCFGDVYYENRNL
FEETNWKRMVDHKRPGRISQELRAIMNLPEGQLPPWCMKMKDIGLPTGYPDLKIAGLN
WDITNLKGDVYGKIIPNHHSRSKKQGRNYFGALISFETPEFENSKEDTQANAENGRQD
DKIDDEVEHKLDHFQEDISEVTSAEEKLERNEEESEKQLYTVLK"
gene <751961..>752905
/gene="YHM2"
/locus_tag="YMR241W"
/db_xref="GeneID:855282"
mRNA <751961..>752905
/gene="YHM2"
/locus_tag="YMR241W"
/product="Yhm2p"
/transcript_id="NM_001182748.1"
/db_xref="GeneID:855282"
CDS 751961..752905
/gene="YHM2"
/locus_tag="YMR241W"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:9742088]"
/experiment="EXISTENCE:direct assay:GO:0005371
tricarboxylate secondary active transmembrane transporter
activity [PMID:20371607|PMID:9559855]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:20371607|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0006842
tricarboxylic acid transport [PMID:9559855]"
/experiment="EXISTENCE:direct assay:GO:0006843
mitochondrial citrate transmembrane transport
[PMID:20371607]"
/experiment="EXISTENCE:direct assay:GO:0015742
alpha-ketoglutarate transport [PMID:20371607]"
/experiment="EXISTENCE:direct assay:GO:0042645
mitochondrial nucleoid [PMID:9742088]"
/experiment="EXISTENCE:genetic interaction:GO:0000002
mitochondrial genome maintenance [PMID:9742088]"
/experiment="EXISTENCE:mutant phenotype:GO:0000002
mitochondrial genome maintenance [PMID:9742088]"
/note="Citrate and oxoglutarate carrier protein; exports
citrate from and imports oxoglutarate into the
mitochondrion, causing net export of NADPH reducing
equivalents; also associates with mt nucleoids and has a
role in replication and segregation of the mt genome"
/codon_start=1
/product="Yhm2p"
/protein_id="NP_013968.1"
/db_xref="GeneID:855282"
/db_xref="SGD:S000004854"
/translation="MPSTTNTAAANVIEKKPVSFSNILLGACLNLSEVTTLGQPLEVV
KTTMAANRNFTFLESVKHVWSRGGILGYYQGLIPWAWIEASTKGAVLLFVSAEAEYRF
KSLGLNNFASGILGGVTGGVTQAYLTMGFCTCMKTVEITRHKSASAGGVPQSSWSVFK
NIYKKEGIRGINKGVNAVAIRQMTNWGSRFGLSRLVEDGIRKITGKTNKDDKLNPFEK
IGASALGGGLSAWNQPIEVIRVEMQSKKEDPNRPKNLTVGKTFKYIYQSNGLKGLYRG
VTPRIGLGIWQTVFMVGFGDMAKEFVARMTGETPVAKH"
gene complement(<753225..>754220)
/gene="RPL20A"
/locus_tag="YMR242C"
/gene_synonym="RPL18A2"
/db_xref="GeneID:855283"
mRNA complement(join(<753225..753742,754220..>754220))
/gene="RPL20A"
/locus_tag="YMR242C"
/gene_synonym="RPL18A2"
/product="ribosomal 60S subunit protein L20A"
/transcript_id="NM_001182749.1"
/db_xref="GeneID:855283"
CDS complement(join(753225..753742,754220))
/gene="RPL20A"
/locus_tag="YMR242C"
/gene_synonym="RPL18A2"
/experiment="EXISTENCE:curator inference:GO:0002181
cytoplasmic translation [PMID:23874617]"
/experiment="EXISTENCE:curator inference:GO:0003735
structural constituent of ribosome [PMID:23874617]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:23874617]"
/note="Ribosomal 60S subunit protein L20A; homologous to
mammalian ribosomal protein L18A, no bacterial homolog;
RPL20A has a paralog, RPL20B, that arose from the whole
genome duplication"
/codon_start=1
/product="ribosomal 60S subunit protein L20A"
/protein_id="NP_013969.3"
/db_xref="GeneID:855283"
/db_xref="SGD:S000004855"
/translation="MAHFKEYQVIGRRLPTESVPEPKLFRMRIFASNEVIAKSRYWYF
LQKLHKVKKASGEIVSINQINEAHPTKVKNFGVWVRYDSRSGTHNMYKEIRDVSRVAA
VETLYQDMAARHRARFRSIHILKVAEIEKTADVKRQYVKQFLTKDLKFPLPHRVQKST
KTFSYKRPSTFY"
gene <754297..>754386
/locus_tag="YMR242W-A"
/db_xref="GeneID:1466505"
mRNA <754297..>754386
/locus_tag="YMR242W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184616.1"
/db_xref="GeneID:1466505"
CDS 754297..754386
/locus_tag="YMR242W-A"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878147.1"
/db_xref="GeneID:1466505"
/db_xref="SGD:S000028694"
/translation="MFKMKFGDTLPRSDFGTGGNKQAPGLELG"
gene complement(<754838..>756166)
/gene="ZRC1"
/locus_tag="YMR243C"
/gene_synonym="OSR1"
/db_xref="GeneID:855284"
mRNA complement(<754838..>756166)
/gene="ZRC1"
/locus_tag="YMR243C"
/gene_synonym="OSR1"
/product="Zn(2+) transporter ZRC1"
/transcript_id="NM_001182750.1"
/db_xref="GeneID:855284"
CDS complement(754838..756166)
/gene="ZRC1"
/locus_tag="YMR243C"
/gene_synonym="OSR1"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:9712830]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:23836928|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0045121 membrane
raft [PMID:23836928]"
/experiment="EXISTENCE:mutant phenotype:GO:0005385 zinc
ion transmembrane transporter activity [PMID:2693940]"
/experiment="EXISTENCE:mutant phenotype:GO:0006882
intracellular zinc ion homeostasis [PMID:10856230]"
/note="Vacuolar membrane zinc transporter; transports zinc
from cytosol to vacuole for storage; also has role in
resistance to zinc shock resulting from sudden influx of
zinc into cytoplasm; human ortholog SLC30A10 functions as
a Mn transporter and mutations in SLC30A10 cause
neurotoxic accumulation of Mn in liver and brain; ZRC1 has
a paralog, COT1, that arose from the whole genome
duplication"
/codon_start=1
/product="Zn(2+) transporter ZRC1"
/protein_id="NP_013970.1"
/db_xref="GeneID:855284"
/db_xref="SGD:S000004856"
/translation="MITGKELRIISLLTLDTVFFLLEITIGYMSHSLALIADSFHMLN
DIISLLVALWAVDVAKNRGPDAKYTYGWKRAEILGALINAVFLIALCFSIMIEALQRL
IEPQEIQNPRLVLYVGVAGLISNVVGLFLFHDHGSDSLHSHSHGSVESGNNDLDIESN
ATHSHSHASLPNDNLAIDEDAISSPGPSGQIGEVLPQSVVNRLSNESQPLLNHDDHDH
SHESKKPGHRSLNMHGVFLHVLGDALGNIGVIAAALFIWKTEYSWRYYSDPIVSLIIT
IIIFSSALPLSRRASRILLQATPSTISADQIQREILAVPGVIAVHDFHVWNLTESIYI
ASIHVQIDCAPDKFMSSAKLIRKIFHQHGIHSATVQPEFVSGDVNEDIRRRFSIIAGG
SPSSSQEAFDSHGNTEHGRKKRSPTAYGATTASSNCIVDDAVNCNTSNCL"
gene <757250..>758317
/locus_tag="YMR244W"
/db_xref="GeneID:855285"
mRNA <757250..>758317
/locus_tag="YMR244W"
/product="uncharacterized protein"
/transcript_id="NM_001182752.1"
/db_xref="GeneID:855285"
CDS 757250..758317
/locus_tag="YMR244W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/note="hypothetical protein; SWAT-GFP fusion protein
localizes to the endoplasmic reticulum and vacuole, while
mCherry fusion localizes to just the vacuole"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013971.1"
/db_xref="GeneID:855285"
/db_xref="SGD:S000004858"
/translation="MVLCKLLTPYFLLSILSVGVFTATAAPSPSIQMTENTNQDHHEH
AKRGGTCAFPNYDGMVAVQKGGSNGGWAMSPDQECSYGSWCPYACKPGQLMGQWDPSA
TTYSYPKCQNGGLYCDSNGNLQKPNSDKDYCYDGKGTVIAKNNANSGDVAFCQTVLPG
NEAMLIPTLVGSGSKQTLAVPGTDYWASSASHYYVNAPGVSVEDACQWGSSANPQGNW
APFVAGSNMDDNQNTFVKIGWNPVYLESSCPFKNVKPSFGIRITCDDESQCEGLPCSI
DPSSNGVNEVTSSGGGSSGAGGGNFCVVTARNGAKANIEVFDVGSGSSSKGKRELNPL
DVITTTVTETKYKTVTVTAKT"
rep_origin 758224..758471
/note="ARS1327; Autonomously Replicating Sequence"
/db_xref="SGD:S000118377"
gene complement(<758517..>758831)
/gene="COA6"
/locus_tag="YMR244C-A"
/db_xref="GeneID:855287"
mRNA complement(<758517..>758831)
/gene="COA6"
/locus_tag="YMR244C-A"
/product="Coa6p"
/transcript_id="NM_001182751.1"
/db_xref="GeneID:855287"
CDS complement(758517..758831)
/gene="COA6"
/locus_tag="YMR244C-A"
/experiment="EXISTENCE:direct assay:GO:0005507 copper ion
binding [PMID:25959673]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005758
mitochondrial intermembrane space [PMID:22984289]"
/experiment="EXISTENCE:mutant phenotype:GO:0006878
intracellular copper ion homeostasis [PMID:24549041]"
/experiment="EXISTENCE:mutant phenotype:GO:0033617
mitochondrial cytochrome c oxidase assembly
[PMID:24549041|PMID:22984289]"
/note="Protein involved in cytochrome c oxidase (Complex
IV) assembly; involved in delivery of copper to Complex
IV; also required for efficient formation of respiratory
supercomplexes comprised of Complexes III and IV;
localizes to the mitochondrial intermembrane space;
ortholog implicated in cardiac defects in zebrafish and
human; transcription is induced in response to the
DNA-damaging agent MMS; protein abundance increases in
response to DNA replication stress"
/codon_start=1
/product="Coa6p"
/protein_id="NP_013972.1"
/db_xref="GeneID:855287"
/db_xref="SGD:S000004857"
/translation="MGLFSFDGGKKESQPPNTRSQRKLCWESRDAFFQCLDKADILDA
MDPKNSKSIKSHCKVENEKFEENCAHSWIKYFKEKRVIDFKREQTIKRIEQEAKQRER
NQ"
gene <759807..>761891
/gene="FAA4"
/locus_tag="YMR246W"
/db_xref="GeneID:855288"
mRNA <759807..>761891
/gene="FAA4"
/locus_tag="YMR246W"
/product="long-chain fatty acid-CoA ligase FAA4"
/transcript_id="NM_001182754.1"
/db_xref="GeneID:855288"
CDS 759807..761891
/gene="FAA4"
/locus_tag="YMR246W"
/EC_number="6.2.1.3"
/experiment="EXISTENCE:direct assay:GO:0004467 long-chain
fatty acid-CoA ligase activity [PMID:7650027]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet [PMID:34161133|PMID:10515935|PMID:24868093]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:27136724]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:26777405]"
/experiment="EXISTENCE:genetic interaction:GO:0004467
long-chain fatty acid-CoA ligase activity
[PMID:11477098|PMID:22633490]"
/experiment="EXISTENCE:genetic interaction:GO:0035336
long-chain fatty-acyl-CoA metabolic process
[PMID:11477098]"
/experiment="EXISTENCE:genetic interaction:GO:0044539
long-chain fatty acid import into cell
[PMID:12601005|PMID:27136724]"
/experiment="EXISTENCE:genetic interaction:GO:1905329
sphingoid long-chain base transport [PMID:27136724]"
/experiment="EXISTENCE:mutant phenotype:GO:0004467
long-chain fatty acid-CoA ligase activity [PMID:11477098]"
/experiment="EXISTENCE:mutant phenotype:GO:0035336
long-chain fatty-acyl-CoA metabolic process
[PMID:11477098]"
/note="Long chain fatty acyl-CoA synthetase; activates
fatty acids with a preference for C12:0-C16:0 chain
lengths; role in the competitive import of long-chain
fatty acids and sphingoid long-chain bases; role in
stationary phase survival; localizes to lipid particles
and the plasma membrane; role in
sphingolipid-to-glycerolipid metabolism; forms cytoplasmic
foci upon replication stress; faa1 faa4 double null
complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6,
SLC27A2, or 4"
/codon_start=1
/product="long-chain fatty acid-CoA ligase FAA4"
/protein_id="NP_013974.1"
/db_xref="GeneID:855288"
/db_xref="SGD:S000004860"
/translation="MTEQYSVAVGEAANEHETAPRRNIRVKDQPLIRPINSSASTLYE
FALECFTKGGKRDGMAWRDIIDIHETKKTIVKRVDGKDKPIEKTWLYYELTPYITMTY
EEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFLGCMSQGIPVVTAYDTL
GESGLIHSMVETDSVAIFTDNQLLSKLAVPLKTAKNVKFVIHNEPIDPSDKRQNGKLY
KAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKDEVELHFPKPEDPACIMYTSGSTGT
PKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILG
YANVKTLTPTSTRNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWT
VYALKERNIPCSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLSNLLCPMLI
GYGLTEGVANACVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAKNNQGELLFKGAP
ICSEYYKNPEETAAAFTDDGWFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEK
LESIYRSNPYVQNICVYADENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHE
KKLQDAVCKDMLSTAKSQGLNGIELLCGIVFFEEEWTPENGLVTSAQKLKRRDILAAV
KPDVERVYKENT"
gene complement(762110..763113)
/gene="SNR86"
/locus_tag="YNCM0034C"
/db_xref="GeneID:9164959"
ncRNA complement(762110..763113)
/ncRNA_class="snoRNA"
/gene="SNR86"
/locus_tag="YNCM0034C"
/product="SNR86"
/experiment="EXISTENCE:curator inference:GO:0005730
nucleolus [PMID:15923376]"
/experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA
pseudouridylation guide activity [PMID:15923376]"
/experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA
pseudouridine synthesis [PMID:15923376]"
/experiment="EXISTENCE:physical interaction:GO:0031429 box
H/ACA snoRNP complex [PMID:15923376]"
/note="H/ACA box small nucleolar RNA (snoRNA); guides
pseudouridylation of large subunit (LSU) rRNA at position
U2314"
/transcript_id="NR_132248.1"
/db_xref="GeneID:9164959"
/db_xref="SGD:S000119075"
gene complement(<763351..>768039)
/gene="RKR1"
/locus_tag="YMR247C"
/gene_synonym="LTN1"
/db_xref="GeneID:855289"
mRNA complement(<763351..>768039)
/gene="RKR1"
/locus_tag="YMR247C"
/gene_synonym="LTN1"
/product="ubiquitin-protein ligase RKR1"
/transcript_id="NM_001182755.1"
/db_xref="GeneID:855289"
CDS complement(763351..768039)
/gene="RKR1"
/locus_tag="YMR247C"
/gene_synonym="LTN1"
/EC_number="2.3.2.27"
/experiment="EXISTENCE:direct assay:GO:0004842
ubiquitin-protein transferase activity [PMID:17283062]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:17283062]"
/experiment="EXISTENCE:direct assay:GO:0016567 protein
ubiquitination [PMID:17283062]"
/experiment="EXISTENCE:direct assay:GO:0022626 cytosolic
ribosome [PMID:27385828]"
/experiment="EXISTENCE:direct assay:GO:0043023 ribosomal
large subunit binding [PMID:25554787]"
/experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin
protein ligase activity [PMID:27385828]"
/experiment="EXISTENCE:direct assay:GO:0072344 rescue of
stalled ribosome [PMID:27385828]"
/experiment="EXISTENCE:direct assay:GO:1990112 RQC complex
[PMID:23178123]"
/experiment="EXISTENCE:direct assay:GO:1990116
ribosome-associated ubiquitin-dependent protein catabolic
process [PMID:27385828]"
/experiment="EXISTENCE:genetic interaction:GO:0006325
chromatin organization [PMID:17283062]"
/experiment="EXISTENCE:genetic interaction:GO:0010498
proteasomal protein catabolic process [PMID:24261871]"
/experiment="EXISTENCE:genetic interaction:GO:0030163
protein catabolic process [PMID:27481473]"
/experiment="EXISTENCE:mutant phenotype:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:20835226]"
/experiment="EXISTENCE:mutant phenotype:GO:0010498
proteasomal protein catabolic process [PMID:24261871]"
/experiment="EXISTENCE:mutant phenotype:GO:0016567 protein
ubiquitination [PMID:20835226]"
/experiment="EXISTENCE:mutant phenotype:GO:0030163 protein
catabolic process [PMID:27481473]"
/experiment="EXISTENCE:mutant phenotype:GO:0031509
subtelomeric heterochromatin formation [PMID:17283062]"
/experiment="EXISTENCE:mutant phenotype:GO:0072344 rescue
of stalled ribosome [PMID:26943317]"
/experiment="EXISTENCE:mutant phenotype:GO:1990116
ribosome-associated ubiquitin-dependent protein catabolic
process [PMID:23358411|PMID:23479637]"
/experiment="EXISTENCE:physical interaction:GO:1990112 RQC
complex [PMID:23479637]"
/note="RING domain E3 ubiquitin ligase; involved in
ubiquitin-mediated degradation of non-stop proteins and
translationally stalled ER membrane proteins; component of
ribosome-bound RQC (ribosome quality control) complex;
degrades products of mRNAs lacking a termination codon
regardless of a poly(A) tail; functional connections to
chromatin modification; homolog of mouse Listerin,
mutations in which reported to cause neurodegeneration"
/codon_start=1
/product="ubiquitin-protein ligase RKR1"
/protein_id="NP_013975.1"
/db_xref="GeneID:855289"
/db_xref="SGD:S000004861"
/translation="MSFGGINTFQQYNTDLGLGHNGVRISLNYFDGLPDPSLLNSLYS
NELKLIFKSLLKRDETTKEKALMDLSNLISDFNQNEYFFNDIFLLCWSQIYAKLIISD
YKVIRLQSHQITIMLVKSLRKKISKFLKDFIPLILLGTCELDYSVSKPSLNELTECFN
KDPAKINALWAVFQEQLLNLVKEIVVNENEDTISDERYSSKEESEFRYHRVIASAVLL
LIKLFVHNKDVSERNSSSLKVILSDESIWKLLNLKNGQNTNAYETVLRLIDVLYTRGY
MPSHKNIMKLAVKKLLKSLTHITSKNILKVCPVLPSILNLLATLDDYEDGTIWSYDKS
SKEKVLKFLSVSRTSPSPGFFNAVFALYSSTKRHSFLDYYLEWLPFWQKSVQRLNEKG
FSARNSAEVLNEFWTNFLKFAEDSSEERVKKMVESEIFNSLSCGKSLSEYTKLNQTLS
GVFPPDKWEREIEDYFTSDEDIRKIKVSFEKNLFALLVTSPNNESAISRLFDFFVQLI
ETDPSNVFNKYDGVYDALNYFLDSDMIFLNGKIGKFINEIPTLVQESTYQNFAGIMAQ
YSNSKFFKMNTDAITSLEDFFIVALSFNLPKTIILATMNELDNDIYQQLMKSDSLELE
LYIEDFMKNYKFDDSGEIFKGNNKFLNQRTITTLYRSAVANGQVEQFCAVLSKLDETF
FSTLLLNTDFLSCALYEVSEDTNEKLFKLSLQLAKGNSEIANKLAQVILQHAQVYFSP
GAKEKYVTHAVELINGCNDTSQIFFPANAIEVFARYMPAIDYRSSLVSSLSTNTHLLL
TDDKPINLKNMQKLIRYALFLDALLDALPERVNNHIVAFITVVSELVTDYNCLSEEPN
DLYYDFGHTFFKHGKVNLNFSDIVGNVIQPANGGDAMLTFDIAESNSVYFFYYSRVLY
KVLLNSIDTVSSTTLNGLLASVESFVTKTVRDQKSTDKDYLLCAILLLMFNRSNSKDE
ITKLRTLLASQLIGIREVELVDQEFKSLALLNNLLDIPQADKQFVPIAPQRLNMIFRS
ILKWLDSDLAYEPSFSTVRLLLLDFFTKLMRFEGVRDMGITAFELSERLLADSLSMCQ
IDDTLYLLELRSSCLNLYETLSQGVSKNGEEISEYGDEIQENLIELMFLNFNQERNNQ
VSTLFYQKLYKVISSMELKKLESQYKRIFEVVLNDKDIGSNINQSRLLTTLLGSLVVK
TQQDIIIEYELRIQKQTGSDVDGSASDNDVNSKFKLPQKLLQKVTDEVPKEYLEYENK
NSFIKYLWYWHLILMYFKDTSYNMRQIFIEQLKEAGLINRMFDFITDQIDLRDTEFWK
QVDTKEISEYNIVGNNFSPYKEDIFEECKKLLGHTLYQLFNNVGCLTSIWWLNIKDRT
LQNDIEKFVSEFISPILIKNEFDDINSKMDRLTSNDDALTIKLNNITNEVKASYLIDD
QKLEISFKLPKNYPLTNIQVNGVSRVGISEQKWKQWIMSTQHVITGMNGSVLDSLELF
TKNVHLQFSGFEECAICYSILHAVDRKLPSKTCPTCKNKFHGACLYKWFRSSGNNTCP
LCRSEIPFRR"
gene complement(768369..768441)
/locus_tag="YNCM0035C"
/db_xref="GeneID:855290"
tRNA complement(768369..768441)
/locus_tag="YNCM0035C"
/product="tRNA-Ala"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE
analysis; one of 11 nuclear tRNA genes containing the
tDNA-anticodon AGC (converted to IGC in the mature tRNA),
decodes GCU and GCC codons into alanine, one of 16 nuclear
tRNAs for alanine"
/db_xref="GeneID:855290"
/db_xref="SGD:S000006519"
repeat_region 768548..768879
/note="Ty2 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007125"
gene <769283..>769426
/locus_tag="YMR247W-A"
/db_xref="GeneID:1466506"
mRNA <769283..>769426
/locus_tag="YMR247W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184661.1"
/db_xref="GeneID:1466506"
CDS 769283..769426
/locus_tag="YMR247W-A"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/note="hypothetical protein; SWAT-GFP fusion protein
localizes to the endoplasmic reticulum and vacuole, while
mCherry fusion localizes to just the vacuole"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878148.1"
/db_xref="GeneID:1466506"
/db_xref="SGD:S000028849"
/translation="MAHKCASAKLLSGIMALLFNGKSLLRPICLHVHNHLVSNSDTNI
VWP"
gene <770801..>772558
/gene="GAD1"
/locus_tag="YMR250W"
/db_xref="GeneID:855291"
mRNA <770801..>772558
/gene="GAD1"
/locus_tag="YMR250W"
/product="glutamate decarboxylase GAD1"
/transcript_id="NM_001182756.1"
/db_xref="GeneID:855291"
CDS 770801..772558
/gene="GAD1"
/locus_tag="YMR250W"
/EC_number="4.1.1.15"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0004351
glutamate decarboxylase activity [PMID:11031268]"
/experiment="EXISTENCE:mutant phenotype:GO:0006538
glutamate catabolic process [PMID:11031268]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress [PMID:11031268]"
/note="Glutamate decarboxylase; converts glutamate into
gamma-aminobutyric acid (GABA) during glutamate
catabolism; involved in response to oxidative stress"
/codon_start=1
/product="glutamate decarboxylase GAD1"
/protein_id="NP_013976.1"
/db_xref="GeneID:855291"
/db_xref="SGD:S000004862"
/translation="MLHRHGSKQKNFENIAGKVVHDLAGLQLLSNDVQKSAVQSGHQG
SNNMRDTSSQGMANKYSVPKKGLPADLSYQLIHNELTLDGNPHLNLASFVNTFTTDQA
RKLIDENLTKNLADNDEYPQLIELTQRCISMLAQLWHANPDEEPIGCATTGSSEAIML
GGLAMKKRWEHRMKNAGKDASKPNIIMSSACQVALEKFTRYFEVECRLVPVSHRSHHM
LDPESLWDYVDENTIGCFVILGTTYTGHLENVEKVADVLSQIEAKHPDWSNTDIPIHA
DGASGGFIIPFGFEKEHMKAYGMERWGFNHPRVVSMNTSGHKFGLTTPGLGWVLWRDE
SLLADELRFKLKYLGGVEETFGLNFSRPGFQVVHQYFNFVSLGHSGYRTQFQNSLFVA
RAFSFELLNSSKLPGCFEIVSSIHESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLS
KKFHEEYPEVPQAILSSLLRGRGWIIPNYPLPKATDGSDEKEVLRVVFRSEMKLDLAQ
LLIVDIESILTKLIHSYEKVCHHIELASEQTPERKSSFIYEMLLALASPQDDIPTPDE
IEKKNKLKETTTRNYRGTC"
rep_origin 772631..772879
/note="ARS1328; Autonomously Replicating Sequence"
/db_xref="SGD:S000118378"
gene <772915..>774015
/gene="GTO3"
/locus_tag="YMR251W"
/db_xref="GeneID:855292"
mRNA <772915..>774015
/gene="GTO3"
/locus_tag="YMR251W"
/product="omega-class glutathione transferase"
/transcript_id="NM_001182757.1"
/db_xref="GeneID:855292"
CDS 772915..774015
/gene="GTO3"
/locus_tag="YMR251W"
/EC_number="2.5.1.18"
/experiment="EXISTENCE:direct assay:GO:0004364 glutathione
transferase activity [PMID:16709151]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:16936141]"
/note="Omega class glutathione transferase; putative
cytosolic localization"
/codon_start=1
/product="omega-class glutathione transferase"
/protein_id="NP_013977.1"
/db_xref="GeneID:855292"
/db_xref="SGD:S000004863"
/translation="MSEKSASNNKAEFKRQSSPFREIISADHPIYKPAKGRYWLYVAL
PCPWAQRTLITRALKGLAPIIGCSVAHWHLDDKGWRFLEEGDGKTNERHWFDIAGGIS
SVNLNTSTPVANIPNNAHRLLVDGTDEPHYGYKRLSDFYFKTKPDYKGRFTVPVLWDL
ETCTIVNNESSDIIGIMNSAAFDEFVGEEYRQVRLVPRSLEAQITEFNSWVYDKINNG
VYKAGFAECAEVYEREVTSLFQYLDKLENLLDKKYTDLEAEYGKNNKDKILDRYFAIG
DTLTEADVRLYPTIVRFDVVYHQHFKCNLATIRDDYSRIHTWLKNIYWRHEAFQRTTD
FTHIKLGYTRSQPRVNPIGITPLGPKPDIRPP"
gene <774752..>774931
/gene="HOR7"
/locus_tag="YMR251W-A"
/db_xref="GeneID:855293"
mRNA <774752..>774931
/gene="HOR7"
/locus_tag="YMR251W-A"
/product="Hor7p"
/transcript_id="NM_001182758.1"
/db_xref="GeneID:855293"
CDS 774752..774931
/gene="HOR7"
/locus_tag="YMR251W-A"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:15208314]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma
membrane organization [PMID:15208314]"
/note="hypothetical protein; overexpression suppresses
Ca2+ sensitivity of mutants lacking inositol
phosphorylceramide mannosyltransferases Csg1p and Csh1p;
transcription is induced under hyperosmotic stress and
repressed by alpha factor; HOR7 has a paralog, DDR2, that
arose from the whole genome duplication"
/codon_start=1
/product="Hor7p"
/protein_id="NP_013978.1"
/db_xref="GeneID:855293"
/db_xref="SGD:S000004864"
/translation="MKLSQVVVSAVAFTGLVSAANSSNSSSSKNAAQPIAGLNNGKVA
GAAGVALAGALAFLI"
gene complement(<775315..>775719)
/gene="MLO1"
/locus_tag="YMR252C"
/db_xref="GeneID:855294"
mRNA complement(<775315..>775719)
/gene="MLO1"
/locus_tag="YMR252C"
/product="Mlo1p"
/transcript_id="NM_001182759.1"
/db_xref="GeneID:855294"
CDS complement(775315..775719)
/gene="MLO1"
/locus_tag="YMR252C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095]"
/note="Mitochondrial hypothetical protein; green
fluorescent protein (GFP)-fusion protein localizes to
mitochondria; MLO1 is not an essential gene"
/codon_start=1
/product="Mlo1p"
/protein_id="NP_013979.1"
/db_xref="GeneID:855294"
/db_xref="SGD:S000004865"
/translation="MFGKVFVSYIRTRIGFKPLSTIYTPVSSSSLSFDKEACFPFKKW
HELNMSQKQEFIQRFVKNYRHQYPSSKTNVSLKGLSIGMDEHNDSPSVFGIFYNDIWK
SFKNEQLGTNNDNMKSGSRFSHPSFKQLLIQK"
gene complement(<775946..>777190)
/locus_tag="YMR253C"
/db_xref="GeneID:855295"
mRNA complement(<775946..>777190)
/locus_tag="YMR253C"
/product="uncharacterized protein"
/transcript_id="NM_001182760.1"
/db_xref="GeneID:855295"
CDS complement(775946..777190)
/locus_tag="YMR253C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="Putative membrane protein, involved in salt
tolerance; green fluorescent protein (GFP)-fusion protein
localizes to the cytoplasm in a punctate pattern; YMR253C
is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013980.1"
/db_xref="GeneID:855295"
/db_xref="SGD:S000004866"
/translation="MNPSVPKVMKRENNTHLLVSKEMNDTSLQLPSTTRSLSPKESNS
NEDFNVDGNETTLQRISKDYLKPNIGLVLLTVSYFFNSAMVVSTKVLENDPDDIANDR
QIKPLQILLVRMVITYIGTLIYMYINKSTISDVPFGKPEVRKWLVLRGCTGFFGVFGM
YYSLMYLTISDAVLITFLAPSLTIFLSWVILRERFTKVEALGSLISLLGVVLIVRPSF
LFGTPELTDSSSQIVESSDPKSRLIATLVGLWGVLGMSCVYIIIRYIGKRAHAIMSVS
YFSLITAIVSFIGINTIPSMKFQIPHSKKQWILFGNLGVSGFIFQLLLTMGIQRERAG
RGSLMTYTQLLYAVFWDVALYKHWPNIWSWIGMIIIISATLWVIRIRAANNETTAKDL
TPIIDDEENSIPLTEFDLSDSK"
gene complement(<777615..>777923)
/locus_tag="YMR254C"
/db_xref="GeneID:855296"
mRNA complement(<777615..>777923)
/locus_tag="YMR254C"
/product="uncharacterized protein"
/transcript_id="NM_001348870.1"
/db_xref="GeneID:855296"
CDS complement(777615..777923)
/locus_tag="YMR254C"
/note="hypothetical protein; conserved across S.
cerevisiae strains"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335809.1"
/db_xref="GeneID:855296"
/db_xref="SGD:S000004867"
/translation="MVPLILLILLFSKFSTFLRPVNHVLVTKYTAIVNTKWQTTPSII
DVTYTMHVFYMTIILILVRKQMQSIHAFLGSLCLPSHVLDFSIVRDILSWYFLETVAV
"
gene <778001..>778567
/gene="GFD1"
/locus_tag="YMR255W"
/db_xref="GeneID:855297"
mRNA <778001..>778567
/gene="GFD1"
/locus_tag="YMR255W"
/product="Gfd1p"
/transcript_id="NM_001182762.1"
/db_xref="GeneID:855297"
CDS 778001..778567
/gene="GFD1"
/locus_tag="YMR255W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10523319]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding [PMID:10610322]"
/experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA
export from nucleus [PMID:10523319|PMID:10610322]"
/note="Coiled-coiled hypothetical protein; identified as a
high-copy suppressor of a dbp5 mutation; protein abundance
increases in response to DNA replication stress"
/codon_start=1
/product="Gfd1p"
/protein_id="NP_013982.1"
/db_xref="GeneID:855297"
/db_xref="SGD:S000004868"
/translation="MPLESIWADAPDEEPIKKQKPSHKRSNNNKKNNNSRWSNESSSN
NKKKDSVNKVKNNKGNHESKTKNKIKETLPREKKPPHSQGKISPVSESLAINPFSQKA
TEISPPPVSPSKMKTTKTQSKQDTASKMKLLKKKIEEQREILQKTHHKNQQQQVLMDF
LNDEGSSNWVDDDEEELILQRLKTSLKI"
gene complement(<778945..>779127)
/gene="COX7"
/locus_tag="YMR256C"
/db_xref="GeneID:855298"
mRNA complement(<778945..>779127)
/gene="COX7"
/locus_tag="YMR256C"
/product="cytochrome c oxidase subunit VII"
/transcript_id="NM_001182763.1"
/db_xref="GeneID:855298"
CDS complement(778945..779127)
/gene="COX7"
/locus_tag="YMR256C"
/experiment="EXISTENCE:direct assay:GO:0004129
cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005751
mitochondrial respiratory chain complex IV [PMID:1331058]"
/experiment="EXISTENCE:direct assay:GO:0006123
mitochondrial electron transport, cytochrome c to oxygen
[PMID:1331058]"
/note="Subunit VII of cytochrome c oxidase (Complex IV);
Complex IV is the terminal member of the mitochondrial
inner membrane electron transport chain"
/codon_start=1
/product="cytochrome c oxidase subunit VII"
/protein_id="NP_013983.1"
/db_xref="GeneID:855298"
/db_xref="SGD:S000004869"
/translation="MANKVIQLQKIFQSSTKPLWWRHPRSALYLYPFYAIFAVAVVTP
LLYIPNAIRGIKAKKA"
gene complement(<779629..>782031)
/gene="PET111"
/locus_tag="YMR257C"
/db_xref="GeneID:855299"
mRNA complement(<779629..>782031)
/gene="PET111"
/locus_tag="YMR257C"
/product="Pet111p"
/transcript_id="NM_001182764.1"
/db_xref="GeneID:855299"
CDS complement(779629..782031)
/gene="PET111"
/locus_tag="YMR257C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:11106667]"
/experiment="EXISTENCE:mutant phenotype:GO:0033617
mitochondrial cytochrome c oxidase assembly
[PMID:3034718]"
/experiment="EXISTENCE:mutant phenotype:GO:0045182
translation regulator activity [PMID:3034718]"
/experiment="EXISTENCE:mutant phenotype:GO:0070131
positive regulation of mitochondrial translation
[PMID:3034718]"
/note="Mitochondrial translational activator specific for
the COX2 mRNA; located in the mitochondrial inner
membrane"
/codon_start=1
/product="Pet111p"
/protein_id="NP_013984.1"
/db_xref="GeneID:855299"
/db_xref="SGD:S000004870"
/translation="MLQRRFISSSGIKRLLHRESNKVMHTVFFKVRYYSTELIKKKHK
EDIEDWVKAQLKDSSTISGVYESRNKLDWMDSITKSPSSLDILKNQYNIVKDKDFGIL
WKQKFESADPDILMTIISLSTNQKVLFSIQQLLILINSLHFLKRDYDIGQIYTTYEQF
TPLLASHTDKGTYGQFIEIMLVVQHNLHHFDVCETLFAEYIKYCKVKPQMISLGLNSF
IRSNNTQLAVEFYTQAITNPDTFPITEKQLFEFLRCMERYLDMSSMKHIFYLWLKVKC
GDEQSSSTNLPSFKTLAIIHRMLLRFSNTDELNDFLTNPVVLSTGYTSSVQFELIEFC
HSLYCIKGDRTKSIDDSILMERVDKFITRLNNNISTRKELYMSVVQAYVSTNNFENLK
VILEKIQRDNDISIDGSFHLCISRYFVNTNQFEGLFKYYRSVVKTTDGKTRLRPAFIQ
QLWSCAVNVYPMLAKEITNDLLVTLKRSQYSKCLTWVYTFLQENAHIHTRKINGGEDS
SLSGFNAVDFERFEEFKKKVSHNDVYGAELVISNSLKEGIAPQFSFLYSVLALCLRNS
LTGLARVVDVILRTRFRYIPLKVDILWLKWEIISNYRSFEKLSAEHLKELEFKLKEFE
RVHQKELSVQNYLQLTQICFHTRDFKYACYLISQARKNLDTSNNKQWMMYYMTSLKLA
SRMHESERFSRILKDWNCNHRASLITPGCIRQIKGFMKYFEKRPAYISTAASIDNKEI
KDRIDELVLRYVDYKYQGLENMRKLTLFLKEWFDEEISLLKLEQNERKMKLFEENKKE
EE"
gene complement(<782620..>784281)
/gene="ROY1"
/locus_tag="YMR258C"
/db_xref="GeneID:855300"
mRNA complement(<782620..>784281)
/gene="ROY1"
/locus_tag="YMR258C"
/product="Roy1p"
/transcript_id="NM_001182765.1"
/db_xref="GeneID:855300"
CDS complement(782620..784281)
/gene="ROY1"
/locus_tag="YMR258C"
/experiment="EXISTENCE:direct assay:GO:0005095 GTPase
inhibitor activity [PMID:21389113]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0006623
protein targeting to vacuole [PMID:21389113]"
/experiment="EXISTENCE:genetic interaction:GO:0006897
endocytosis [PMID:21389113]"
/note="GTPase inhibitor with similarity to F-box proteins;
inhibits Ypt52p GTPase activity by preventing Ypt52p from
binding GTP; involved in regulating intracellular
trafficking; physically interacts with Skp1p"
/codon_start=1
/product="Roy1p"
/protein_id="NP_013985.1"
/db_xref="GeneID:855300"
/db_xref="SGD:S000004871"
/translation="MAFQDQDIFIVFSHASLFLNQNDLLSLSLTSKKMHDMIAIPRLY
SNIHITKNPVLRTNKWFLDGGKTYVSGYRSVLKTGDKNDIFLYDRIERLLETSHLKCI
KQLTIDEDLFHNREEGLQLLQRLVNEITDLDVIESLDIKDPTLFELCSAKYYRLSSLK
KRVVYGETGFDGIKLWQNFKSLKWQLPESLDLQNVIIPEVGVMLMKQLNGGELEIKDE
AYSSLRVFEYFDSLNLRFKNLRRLKLNHVHKQGDGSATSMRLSSRAFKDVVNLSNLKA
LELEFSCEVDDCECDDDFLQDITGNLVSLTSLGFIEKTFTKKGYHYMDEKWDLVVNKF
ILNLPNVSKDLRLLSIRHDPPLNGKGIDTVDGNLLRRKKLYEKVLPKLTSLETIIAPT
VLQSITSYEMYACDLLWNGCKCAFCSKYLPLFDKYIMNHQYFSTPDARYLDIIPIVFA
AYTGKSLAKRFDPQKNWDLDLLQYAPEDTTWNFHGFERIHHFASYECYFDESSFEPLA
TIISHFFYPYMNYLIKILPNLRQTMLSGIYFSVSPELHTYETIYD"
gene complement(<784621..>788883)
/gene="TRM732"
/locus_tag="YMR259C"
/db_xref="GeneID:855301"
mRNA complement(<784621..>788883)
/gene="TRM732"
/locus_tag="YMR259C"
/product="tRNA methylation protein TRM732"
/transcript_id="NM_001182766.1"
/db_xref="GeneID:855301"
CDS complement(784621..788883)
/gene="TRM732"
/locus_tag="YMR259C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0002130 wobble
position ribose methylation [PMID:22912484]"
/experiment="EXISTENCE:physical interaction:GO:0002130
wobble position ribose methylation [PMID:22912484]"
/note="Protein involved in 2'-O-methylation of C32 of
substrate tRNAs; interacts with 2'-O-ribose
methyltransferase Trm7p; green fluorescent protein
(GFP)-fusion protein localizes to the cytoplasm;
non-essential gene; yeast null mutant can be functionally
complemented by human THADA, mutations in which have been
implicated in epithelial thyroid adenomas, type 2
diabetes, and polycystic ovary syndrome (PCOS)"
/codon_start=1
/product="tRNA methylation protein TRM732"
/protein_id="NP_013986.1"
/db_xref="GeneID:855301"
/db_xref="SGD:S000004872"
/translation="MTTDVQFSSQEIELFRVKEFLIANNPAKINNENKDAVLTQIEHD
FRYLIQYIKDGLPNLNESTRLIFPDTFSICLLRSHQIIASKKIDSQEFLSAVKEQLLT
EANANIIFEYVLDFWADGGAPLMNALRDLFSKLLNLLKITYPMSTLKDVLFNWMNEIL
EVPSTLRVQYYLIDALSSDFDLYYIIEKKPHFIDNSFSLMNSDLLANSVGKCIVSLLL
NIYEKHFKKNESFVQEWIQLWKSCALKYIHDKQYTKSINLYIMIPLFKNMPNSAFTLF
LECMSNKDPSLLLSLLKIGQELGIEEEPFCDNKYTTVDSVNKLIEQDEYKLQVFEILT
FSTKKSKPIRPFVFKTIKQYLYVFFVDTELERRNYFCSSMKHFIFRTRDCAYSLARDA
RKLKKAEKFPDEQREKLAQVEEARAFLVWLCNFIKYNLAPGTLYQANVTSLKLMHILI
KSGVDKSTPQKFLDNQNKREYPFSIPILQDVTFLRLLIDLLVSNYADVRELSKEMLFI
MISADESRGLFLDTLDANALKWTATSLLSDYEKGDAGATVYEFIFTVMGSQRSFIDQT
IDILAQMVQNLQNDSIGCAENSIGPHFAALSLILNKFNSEENHQDTSKIISKLINLVL
KSWEATRNVVCHDSAHGILPEKYANCGVPDQVIISHAFRAIKEASYLLETILKKYPLT
RDQLDSIGDLFIVQLSTIRHSGAFQAVLPGLKAFCIRCQLEFPAILEELLSKSVKSLK
SKTQHITRRSGGLPFLVTTVLSAEVTKGRPLLQKTFENLLLVARLPIPPHQDEFDLPQ
VNAINCINAIFVEPKLSVHCTSFVSEALELALLNFDCDIWALRNCSIMLFTSLQNRIF
GKVGRSVSAKLFFTKYSGLRQLLLNILNSSIAQYSGSERKSYQIESIFLVLNVLLRLR
PTAGYTGLKEFNVSVYECLSNENWKIRDMASRVLHMLSENFEEEIRKLLDLASIAKQN
QLHGHLLALQQLVPQYLSGTRDMELIQRILEKKRMLLLENKCFITKKAYLKLTCCILE
TCDIPDSILKDYISTLRNTFIAENNEYVVDGSKQLYLAQILDMLLKYEDSIYLDDICL
LGLYSPFYEAQLSTLQYMNTNFHWETTRNSEFLEQLQLLLRVPDLLPMAKALVVKILS
RKKNTLSLTTCTDLLKTNNSEDTKLAAVSSLSAKLSSQTFHQVWNLLQGFFADSCSKD
FRLASLECLTAYPESCKNSRILLQLYNFLWDDDSEIREKASFYLNKNFIQTADWEYNR
NTSVTALIFTKKFVDVFTSSEVVEELCLQLFQYLNEYDMFAAEESAKNCLFTIEKDNQ
FINELQKAMHILNMIKLTGRDISKCYKDQIHHLKSALLEHFNTEDFKDSPLGWCSNAE
IFSRITLLKELIQHYSPSDYENFINVLTKHSVHPLIISYSQL"
gene complement(<789378..>789839)
/gene="TIF11"
/locus_tag="YMR260C"
/db_xref="GeneID:855302"
mRNA complement(<789378..>789839)
/gene="TIF11"
/locus_tag="YMR260C"
/product="Tif11p"
/transcript_id="NM_001182767.1"
/db_xref="GeneID:855302"
CDS complement(789378..789839)
/gene="TIF11"
/locus_tag="YMR260C"
/experiment="EXISTENCE:direct assay:GO:0001731 formation
of translation preinitiation complex
[PMID:12008673|PMID:15664195|PMID:17434125]"
/experiment="EXISTENCE:direct assay:GO:0003725
double-stranded RNA binding [PMID:17673174]"
/experiment="EXISTENCE:direct assay:GO:0003743 translation
initiation factor activity [PMID:12008673]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:26777405]"
/experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic
43S preinitiation complex [PMID:16380131]"
/experiment="EXISTENCE:direct assay:GO:0031369 translation
initiation factor binding [PMID:10982835|PMID:16380131]"
/experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic
48S preinitiation complex [PMID:17242201]"
/experiment="EXISTENCE:direct assay:GO:0043024 ribosomal
small subunit binding
[PMID:17434125|PMID:12860115|PMID:16461768]"
/experiment="EXISTENCE:genetic interaction:GO:0001732
formation of cytoplasmic translation initiation complex
[PMID:17242201]"
/experiment="EXISTENCE:mutant phenotype:GO:0001677
formation of translation initiation ternary complex
[PMID:20048003]"
/experiment="EXISTENCE:mutant phenotype:GO:0001731
formation of translation preinitiation complex
[PMID:12514125|PMID:15838098|PMID:16193068|PMID:17332751]"
/experiment="EXISTENCE:mutant phenotype:GO:0001732
formation of cytoplasmic translation initiation complex
[PMID:16461768|PMID:20048003]"
/experiment="EXISTENCE:mutant phenotype:GO:0002188
translation reinitiation [PMID:16193068|PMID:20048003]"
/experiment="EXISTENCE:mutant phenotype:GO:0043024
ribosomal small subunit binding [PMID:16193068]"
/note="Translation initiation factor eIF1A; essential
protein that forms a complex with Sui1p (eIF1) and 40S
ribosomal subunit and scans for start codons; C-terminus
associates with Fun12p (eIF5B); N terminus interacts with
eIF2 and eIF3; ortholog of bacterial translation
initiation factor IF1"
/codon_start=1
/product="Tif11p"
/protein_id="NP_013987.1"
/db_xref="GeneID:855302"
/db_xref="SGD:S000004873"
/translation="MGKKNTKGGKKGRRGKNDSDGPKRELIYKEEGQEYAQITKMLGN
GRVEASCFDGNKRMAHIRGKLRKKVWMGQGDIILVSLRDFQDDQCDVVHKYNLDEART
LKNQGELPENAKINETDNFGFESDEDVNFEFGNADEDDEEGEDEELDIDDI"
gene complement(<790205..>793369)
/gene="TPS3"
/locus_tag="YMR261C"
/db_xref="GeneID:855303"
mRNA complement(<790205..>793369)
/gene="TPS3"
/locus_tag="YMR261C"
/product="trehalose 6-phosphate synthase/phosphatase
complex subunit"
/transcript_id="NM_001182768.1"
/db_xref="GeneID:855303"
CDS complement(790205..793369)
/gene="TPS3"
/locus_tag="YMR261C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:genetic interaction:GO:0004805
trehalose-phosphatase activity [PMID:9837904]"
/experiment="EXISTENCE:mutant phenotype:GO:0003825
alpha,alpha-trehalose-phosphate synthase (UDP-forming)
activity [PMID:9837904]"
/experiment="EXISTENCE:mutant phenotype:GO:0005992
trehalose biosynthetic process [PMID:9837904]"
/experiment="EXISTENCE:mutant phenotype:GO:0030234 enzyme
regulator activity [PMID:9837904]"
/experiment="EXISTENCE:physical interaction:GO:0005946
alpha,alpha-trehalose-phosphate synthase complex
(UDP-forming) [PMID:9837904]"
/note="Regulatory subunit of trehalose-6-phosphate
synthase/phosphatase; involved in synthesis of storage
carbohydrate trehalose; expression is induced by stress
conditions and repressed by the Ras-cAMP pathway; TPS3 has
a paralog, TSL1, that arose from the whole genome
duplication"
/codon_start=1
/product="trehalose 6-phosphate synthase/phosphatase
complex subunit"
/protein_id="NP_013988.1"
/db_xref="GeneID:855303"
/db_xref="SGD:S000004874"
/translation="MTIIVASLFLPYTPQFEADVTNSDTAKLVESSMIKVDCNNQELS
NNKQERSSSVTSASSHYIGLPQEAQINGEPLQRANVGSPATGVNYHNEMEMLSSEQFL
EELTANATHAANSGIPPANNPVSSGSTAQRPSVEEFFSAPSARVCSPSQEASASSISA
SRSSAHHNDLSSSLMKNPNLSFDSHPPRVRSSSKSAVITPVSKSVPDVDPAVVDVAKV
REEFQQQASLPSMKRVSGSTAGDSSIASSSSNLRYSQQFQDNFIEDTDSEDDIDSDLE
TDATKKYNVPKFGGYSNNAKLRASLMRNSYELFKHLPWTIVDSDKGNGSLKNAVNIAV
AEKTVKEPVSWVGTMGIPTDELPHEVCHKISKKLEQDFSSFPVVTDDITFKGAYKNYA
KQILWPTLHYQIPDNPNSKAFEDHSWDYYQKVNQKFSDRIVSVYKPGDTIWIHDYHLM
LVPQMVREKLPKAKIGFFLHVSFPSSEVFRCLANRERILEGIIGANFVGFQTKEYKRH
FLQTCNRLLAADVSNDEVKYHCNIVSVMYAPIGIDYYHLTSQLRNGSVLEWRQLIKER
WRNKKLIVCRDQFDRIRGLQKKMLAYERFLIENPEYIEKVVLIQICIGKSSDPEYERQ
IMVVVDRINSLSSNISISQPVVFLHQDLDFAQYLALNCEADVFLVDALREGMNLTCHE
FIVSSFEKNAPLLLSEFTGSSSVLKEGAILINPWDINHVAQSIKRSLEMSPEEKRRRW
KKLFKSVIEHDSDNWITKCFEYINNAWESNQETSTVFNLAPEKFCADYKASKKHLFIF
KISEPPTSRMLSLLSELSSNNIVYVLSSFTKNTFESLYNGVLNIGLIAENGAYVRVNG
SWYNIVEELDWMKEVAKIFDEKVERLPGSYYKIADSMIRFHTENADDQDRVPTVIGEA
ITHINTLFDDRDIHAYVHKDIVFVQQTGLALAAAEFLMKFYNSGVSPTDNSRISLSRT
SSSMSVGNNKKHFQNQVDFVCVSGSTSPIIEPLFKLVKQEVEKNNLKFGYTILYGSSR
STYAKEHINGVNELFTILHDLTAA"
gene <793726..>794667
/locus_tag="YMR262W"
/db_xref="GeneID:855304"
mRNA <793726..>794667
/locus_tag="YMR262W"
/product="putative endodeoxyribonuclease"
/transcript_id="NM_001182769.2"
/db_xref="GeneID:855304"
CDS 793726..794667
/locus_tag="YMR262W"
/note="hypothetical protein; interacts weakly with Knr4p;
YMR262W is not an essential gene"
/codon_start=1
/product="putative endodeoxyribonuclease"
/protein_id="NP_013989.2"
/db_xref="GeneID:855304"
/db_xref="SGD:S000004875"
/translation="MNKLVDAHCHVITDPDNTFCGDDGGSQGTLRCVMSSNPYDWNNL
KKLAGRSTSKNDICVGFGVHPWYSHLFYVGSRRDKVSHYQDVLEYKNEEQFDSLVQVL
PEPLDLEEYIKREFNDTLVSVIGEIGLDKLFRLPANGFYMQNEKARLTTVKVKLSHQE
TVFRRFCRLARHTSKPISIHDVKCHGKLNDICNEELLTYHSVKICLHSYTGSKETLLG
QWLKKFPPDRIFVSLSKWINFKDPEEGDALVRSLPSTCILTETDYPIDNPDPSYQKAL
TEQLQYLNAQIARAWDETLDASQAALRVYENFQKFIK"
gene <794919..>795524
/gene="SAP30"
/locus_tag="YMR263W"
/db_xref="GeneID:855305"
mRNA <794919..>795524
/gene="SAP30"
/locus_tag="YMR263W"
/product="Sap30p"
/transcript_id="NM_001182770.1"
/db_xref="GeneID:855305"
CDS 794919..795524
/gene="SAP30"
/locus_tag="YMR263W"
/experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L
complex
[PMID:16286007|PMID:16286008|PMID:16314178|PMID:19040720]"
/experiment="EXISTENCE:direct assay:GO:0070210
Rpd3L-Expanded complex [PMID:19040720]"
/experiment="EXISTENCE:mutant phenotype:GO:0003714
transcription corepressor activity [PMID:9651585]"
/experiment="EXISTENCE:mutant phenotype:GO:0016479
negative regulation of transcription by RNA polymerase I
[PMID:19270272]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:17210643|PMID:20398213]"
/experiment="EXISTENCE:mutant phenotype:GO:0061186
negative regulation of silent mating-type cassette
heterochromatin formation [PMID:10388812|PMID:16286008]"
/experiment="EXISTENCE:mutant phenotype:GO:0061188
negative regulation of rDNA heterochromatin formation
[PMID:10388812|PMID:16286008|PMID:10082585]"
/experiment="EXISTENCE:mutant phenotype:GO:0061408
positive regulation of transcription from RNA polymerase
II promoter in response to heat stress [PMID:20398213]"
/experiment="EXISTENCE:mutant phenotype:GO:2000219
positive regulation of invasive growth in response to
glucose limitation [PMID:18202364]"
/note="Component of Rpd3L histone deacetylase complex;
involved in silencing at telomeres, rDNA, and silent
mating-type loci; involved in telomere maintenance"
/codon_start=1
/product="Sap30p"
/protein_id="NP_013990.1"
/db_xref="GeneID:855305"
/db_xref="SGD:S000004876"
/translation="MARPVNTNAETESRGRPTQGGGYASNNNGSCNNNNGSNNNNNNN
NNNNNNSNNSNNNNGPTSSGRTNGKQRLTAAQQQYIKNLIETHITDNHPDLRPKSHPM
DFEEYTDAFLRRYKDHFQLDVPDNLTLQGYLLGSKLGAKTYSYKRNTQGQHDKRIHKR
DLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFRG"
gene <795805..>796416
/gene="CUE1"
/locus_tag="YMR264W"
/gene_synonym="KIS4"
/db_xref="GeneID:855306"
mRNA <795805..>796416
/gene="CUE1"
/locus_tag="YMR264W"
/gene_synonym="KIS4"
/product="Cue1p"
/transcript_id="NM_001182771.1"
/db_xref="GeneID:855306"
CDS 795805..796416
/gene="CUE1"
/locus_tag="YMR264W"
/gene_synonym="KIS4"
/experiment="EXISTENCE:direct assay:GO:0000837 Doa10p
ubiquitin ligase complex [PMID:16873066]"
/experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p
ubiquitin ligase ERAD-L complex [PMID:16873066]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:9388185]"
/experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin
binding [PMID:23665229]"
/experiment="EXISTENCE:direct assay:GO:0097027
ubiquitin-protein transferase activator activity
[PMID:18321851]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:9388185]"
/experiment="EXISTENCE:mutant phenotype:GO:0097051
establishment of protein localization to endoplasmic
reticulum membrane [PMID:9388185]"
/note="Ubiquitin-binding protein; ER membrane protein that
recruits and integrates the ubiquitin-conjugating enzyme
Ubc7p into ER membrane-bound ubiquitin ligase complexes
that function in the ER-associated degradation (ERAD)
pathway for misfolded proteins; contains a CUE domain that
binds ubiquitin to facilitate intramolecular
monoubiquitination and to promote diubiquitin elongation,
facilitating polyubiquitin chain formation"
/codon_start=1
/product="Cue1p"
/protein_id="NP_013991.1"
/db_xref="GeneID:855306"
/db_xref="SGD:S000004877"
/translation="MEDSRLLITLILVFGVIFLKKFFQSNQHPSAQRLSATGVNAHGR
PQGSTQNALRRTGRVNGGHPVTTQMVETVQNLAPNLHPEQIRYSLENTGSVEETVERY
LRGDEFSFPPGFEPSRAPMGANAAVDNNAAGGGEFNDPRKKNMICAENLLDKFHVDLN
EDMSNLSFKDLDIEERKRLLVWQARKNLETKLQSDKDLQSLLT"
gene complement(<796540..>797925)
/locus_tag="YMR265C"
/db_xref="GeneID:855307"
mRNA complement(<796540..>797925)
/locus_tag="YMR265C"
/product="uncharacterized protein"
/transcript_id="NM_001182772.1"
/db_xref="GeneID:855307"
CDS complement(796540..797925)
/locus_tag="YMR265C"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_013992.1"
/db_xref="GeneID:855307"
/db_xref="SGD:S000004878"
/translation="MEEFEEFRRKGEMSSRCGNHRVLRKWNSCACELAVPFEVPEHAI
TKLHIYDFDNTLFATPGPTEQLYTRELLNLLTSSTLPNGGWWNEPGFLQAAIEISKTK
PRRYSWNADIVKLAEESYSAKDTISIVLTGREESKFHKLIEHALQTARSHWKCSENEF
RFNAVCLKKRAISEYTSKYKKELMRDFLEYYPSLRELSIYDDRIHQIDAFKSFFHSLD
LPRLKWSAIPVRPFTKSLPREQELEMVMDMVRKNNSQALSTSQKFDLRRTPRQIGYIL
CTASHRLLSIEVIKYLKRRKGRRTFRPKLYEHPLYIPCAEPGKDIPALEIAKVWSNND
TRTFDSEKKVQHISQIFYLEQPGKCIVHFQVTDLAVIASAHHNRRKPLEVYFKATPEP
NRYTFTLFPEYIVTGHFYKRDRIEDLEVVTERLINCKEDIHWVPLDNTIPIKAFFGRF
AKLAAIPCSNA"
gene <798518..>801379
/gene="RSN1"
/locus_tag="YMR266W"
/db_xref="GeneID:855308"
mRNA <798518..>801379
/gene="RSN1"
/locus_tag="YMR266W"
/product="Rsn1p"
/transcript_id="NM_001182773.1"
/db_xref="GeneID:855308"
CDS 798518..801379
/gene="RSN1"
/locus_tag="YMR266W"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:19001347]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0016020 membrane
[PMID:17005914]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/note="Membrane hypothetical protein; overexpression
suppresses NaCl sensitivity of sro7 mutant cells by
restoring sodium pump (Ena1p) localization to the plasma
membrane"
/codon_start=1
/product="Rsn1p"
/protein_id="NP_013993.1"
/db_xref="GeneID:855308"
/db_xref="SGD:S000004879"
/translation="MNSTNSTNSTTTATSTNTSTQQVVTSLVSNGTIFGVFVIAFLIL
RIKLKRIYEPKSSFNLINEEKKPEPLPQGVWQWLKPLLKKSDNFVIQQAGLDGYFFLR
YLFIIAIYCAVSMSYIFPILLSINASNGNHESGLNQLAYQNVKHRGRYFAHVFCGWIF
FWGFLYIIYRELYFYTSMKQAVLASPRYAKKLSSRTVLFQTVPKQYLSEEEFSKLFDG
VKRVWIARGSGSIEAMVKARDNMAIQLEGAETKYLKAALKKIKKLNKKSPQLSVSDNI
AEYVPDKKRPHHKINKVAKFFFGKKVDTISYIKEELPKLNQKVKALQEDHENSSPFNS
VFVEFESQYQAQVAAQITTYHAPLFMTPVYIGIEPSDVVWFNLRMFWWERLGREVSAV
SAIVALVILWAFPVAFVGMISNITSLTNEVKWLKFIYKLPKQLLGLLTSLAPTVALAV
LMSFLPKFIRGMAITQGAPSKQNVEYFTQQAYFAFQVIQVFLVTTLSSAATSTVTEIV
KEPTKAMDLLASNLPKASNFFMSYVILQGLSISSGALLQIVPLILFYVLGAFLDGTVR
KKWNRFCGLSSMQWGTAFPVYTNLAVITFSYSIISPLILLFAAVAFFLLYIAYLYNLT
YVYQESPDARGIYYPRALFQTIVGIYIGQICLLGLFAVGKGWGPIVLQVIGICVTVLI
HLHLSAAFDHLSKVIPVDTMKPLDGVSDTPSFKNIYKGIESTKVKKNTFGANIDMDGI
KELPEFPIKKYHKRSESVTEQQVENSIFSENTFEYQFNPANEANADGHAINAENLIED
VPLLADGDTMKIPPAPWWKRFLKPHIYYSYKAVKSRLPEIYGLVDPDERVNDFDISHA
YDYPAVSAQCPELWIPRDPFGFSKLLISDVSGVVEMNDENATIDENLKFTLRDVPPPY
NDVKDEANGEANGEFDTASKENNPFADPKYKEEESRSAV"
gene <801772..>802704
/gene="PPA2"
/locus_tag="YMR267W"
/gene_synonym="IPP2"
/db_xref="GeneID:855309"
mRNA <801772..>802704
/gene="PPA2"
/locus_tag="YMR267W"
/gene_synonym="IPP2"
/product="inorganic diphosphatase PPA2"
/transcript_id="NM_001182774.1"
/db_xref="GeneID:855309"
CDS 801772..802704
/gene="PPA2"
/locus_tag="YMR267W"
/gene_synonym="IPP2"
/EC_number="3.6.1.1"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:mutant phenotype:GO:0004427
inorganic diphosphate phosphatase activity [PMID:1648084]"
/experiment="EXISTENCE:mutant phenotype:GO:0005739
mitochondrion [PMID:1648084]"
/experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
respiration [PMID:1648084]"
/note="Mitochondrial inorganic pyrophosphatase; required
for mitochondrial function and possibly involved in energy
generation from inorganic pyrophosphate; human ortholog,
PPA2, functionally complements the null mutant; mutations
in human PPA2 cause a mitochondrial disease resulting in
sudden unexpected cardiac arrest in infants"
/codon_start=1
/product="inorganic diphosphatase PPA2"
/protein_id="NP_013994.1"
/db_xref="GeneID:855309"
/db_xref="SGD:S000004880"
/translation="MNLLRMNALTSKARSIERLKQTLNILSIRNHRQFSTIQQGSKYT
LGFKKYLTLLNGEVGSFFHDVPLDLNEHEKTVNMIVEVPRWTTGKFEISKELRFNPIV
QDTKNGKLRFVNNIFPYHGYIHNYGAIPQTWEDPTIEHKLGKCDVALKGDNDPLDCCE
IGSDVLEMGSIKKVKVLGSLALIDDGELDWKVIVIDVNDPLSSKIDDLEKIEEYFPGI
LDTTREWFRKYKVPAGKPLNSFAFHEQYQNSNKTIQTIKKCHNSWKNLISGSLQEKYD
NLPNTERAGNGVTLEDSVKPPSQIPPEVQKWYYV"
gene complement(<802888..>804222)
/gene="PRP24"
/locus_tag="YMR268C"
/db_xref="GeneID:855310"
mRNA complement(<802888..>804222)
/gene="PRP24"
/locus_tag="YMR268C"
/product="U6 snRNP complex subunit PRP24"
/transcript_id="NM_001182775.1"
/db_xref="GeneID:855310"
CDS complement(802888..804222)
/gene="PRP24"
/locus_tag="YMR268C"
/experiment="EXISTENCE:direct assay:GO:0000244
spliceosomal tri-snRNP complex assembly [PMID:9452384]"
/experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP
[PMID:11720284]"
/experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA
binding [PMID:20181740]"
/experiment="EXISTENCE:mutant phenotype:GO:0000245
spliceosomal complex assembly [PMID:10022888]"
/experiment="EXISTENCE:physical interaction:GO:0017069
snRNA binding [PMID:16410014]"
/note="Splicing factor that reanneals snRNPs during
spliceosome recycling; reanneals U4 and U6 snRNPs"
/codon_start=1
/product="U6 snRNP complex subunit PRP24"
/protein_id="NP_013995.1"
/db_xref="GeneID:855310"
/db_xref="SGD:S000004881"
/translation="MEYGHHARPDSKRPLDEGSPAAAGLTSKKANEALTRNRELTTVL
VKNLPKSYNQNKVYKYFKHCGPIIHVDVADSLKKNFRFARIEFARYDGALAAITKTHK
VVGQNEIIVSHLTECTLWMTNFPPSYTQRNIRDLLQDINVVALSIRLPSLRFNTSRRF
AYIDVTSKEDARYCVEKLNGLKIEGYTLVTKVSNPLEKSKRTDSATLEGREIMIRNLS
TELLDENLLRESFEGFGSIEKINIPAGQKEHSFNNCCAFMVFENKDSAERALQMNRSL
LGNREISVSLADKKPFLERNEVKRLLASRNSKELETLICLFPLSDKVSPSLICQFLQE
EIHINEKDIRKILLVSDFNGAIIIFRDSKFAAKMLMILNGSQFQGKVIRSGTINDMKR
YYNNQQNHSMKHVKPSCINMMEKGPNLQVKKKIPDKQEQMSNDDFRKMFLGE"
gene <804456..>805091
/gene="TMA23"
/locus_tag="YMR269W"
/gene_synonym="YMR268W-A"
/db_xref="GeneID:855311"
mRNA <804456..>805091
/gene="TMA23"
/locus_tag="YMR269W"
/gene_synonym="YMR268W-A"
/product="Tma23p"
/transcript_id="NM_001182776.1"
/db_xref="GeneID:855311"
CDS 804456..805091
/gene="TMA23"
/locus_tag="YMR269W"
/gene_synonym="YMR268W-A"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:14562095|PMID:17425675]"
/experiment="EXISTENCE:genetic interaction:GO:0042274
ribosomal small subunit biogenesis [PMID:17425675]"
/note="Nucleolar protein implicated in ribosome
biogenesis; deletion extends chronological lifespan"
/codon_start=1
/product="Tma23p"
/protein_id="NP_013996.2"
/db_xref="GeneID:855311"
/db_xref="SGD:S000004882"
/translation="MDSKEYLISYGWKEGEAFREGGLKRPILVKHKRDKKGLGNAPGG
NDGEAWWERLFDGHLKNLDVSTDSNNGSIKFTQNEAVATAVSKSSSPLYRWFVKGEGL
KGTITNLGKKEEASFVVSSASSSKGKKRRRRDEDDNKVKRKKLKKDKKTSNDSESKKK
KKKKSKKESKKGKKSKHSSDEGDKSKHKKSKKSKKHKKEESSARRDRKEHI"
rep_origin 805152..805282
/note="ARS1329; Autonomously Replicating Sequence"
/db_xref="SGD:S000118379"
gene complement(<805326..>806423)
/gene="RRN9"
/locus_tag="YMR270C"
/db_xref="GeneID:855312"
mRNA complement(<805326..>806423)
/gene="RRN9"
/locus_tag="YMR270C"
/product="Rrn9p"
/transcript_id="NM_001182777.1"
/db_xref="GeneID:855312"
CDS complement(805326..806423)
/gene="RRN9"
/locus_tag="YMR270C"
/experiment="EXISTENCE:direct assay:GO:0000500 RNA
polymerase I upstream activating factor complex
[PMID:8846924]"
/experiment="EXISTENCE:direct assay:GO:0001181 RNA
polymerase I general transcription initiation factor
activity [PMID:8846924]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:22362748]"
/experiment="EXISTENCE:direct assay:GO:0017025 TBP-class
protein binding [PMID:9632758]"
/experiment="EXISTENCE:direct assay:GO:0042790 nucleolar
large rRNA transcription by RNA polymerase I
[PMID:8846924]"
/experiment="EXISTENCE:mutant phenotype:GO:0017025
TBP-class protein binding [PMID:9632758]"
/experiment="EXISTENCE:mutant phenotype:GO:0042790
nucleolar large rRNA transcription by RNA polymerase I
[PMID:8846924]"
/experiment="EXISTENCE:physical interaction:GO:0017025
TBP-class protein binding [PMID:9632758]"
/note="Protein involved in promoting high level
transcription of rDNA; subunit of UAF (upstream activation
factor) for RNA polymerase I"
/codon_start=1
/product="Rrn9p"
/protein_id="NP_013997.1"
/db_xref="GeneID:855312"
/db_xref="SGD:S000004883"
/translation="MSDLDEESQIETQIDAPIEDIIRGSELTTTTADKETLKSANELL
DSLEHSHRVDLSLHLYSAYLLKRLLYKANEKKHFYEVNQFVKTQIKDNWTSWPNPNTI
IDPSVDKLYEDIPEGIANVSVQPGEISNRALMHASDMMRVELDAQWQKFLSKSALDHD
VTLDVDELNIPNEISRNILVKLDSLFEGLHDKIAKENEFDVRQDKHSNNIRANQIDDE
PMQANRRIKYTYHDLVSRGCEMNEDMTDIYMKSLELYNDIPEKYKKRKFRLPKQILKK
YHQPKKTSSYLKELLSKTREDFIPVEKLLKDKRLTSKDKSKLQRLNREETEDALNKRT
FFQVKGYLEDENEISDYELDDCLIELPNGNI"
gene complement(<806865..>807548)
/gene="URA10"
/locus_tag="YMR271C"
/db_xref="GeneID:855313"
mRNA complement(<806865..>807548)
/gene="URA10"
/locus_tag="YMR271C"
/product="orotate phosphoribosyltransferase URA10"
/transcript_id="NM_001182778.1"
/db_xref="GeneID:855313"
CDS complement(806865..807548)
/gene="URA10"
/locus_tag="YMR271C"
/EC_number="2.4.2.10"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0004588
orotate phosphoribosyltransferase activity [PMID:2182197]"
/experiment="EXISTENCE:genetic interaction:GO:0006207 'de
novo' pyrimidine nucleobase biosynthetic process
[PMID:2182197]"
/experiment="EXISTENCE:genetic interaction:GO:0046132
pyrimidine ribonucleoside biosynthetic process
[PMID:2182197]"
/experiment="EXISTENCE:mutant phenotype:GO:0004588 orotate
phosphoribosyltransferase activity [PMID:2182197]"
/experiment="EXISTENCE:mutant phenotype:GO:0046132
pyrimidine ribonucleoside biosynthetic process
[PMID:2182197]"
/note="Minor orotate phosphoribosyltransferase (OPRTase)
isozyme; catalyzes the fifth enzymatic step in the de novo
biosynthesis of pyrimidines, converting orotate into
orotidine-5'-phosphate; URA10 has a paralog, URA5, that
arose from the whole genome duplication"
/codon_start=1
/product="orotate phosphoribosyltransferase URA10"
/protein_id="NP_013998.1"
/db_xref="GeneID:855313"
/db_xref="SGD:S000004884"
/translation="MSASTTSLEEYQKTFLELGLECKALRFGSFKLNSGRQSPYFFNL
SLFNSGKLLANLATAYATAIIQSELKFDVIFGPAYKGIPLAAIVCVKLAEIGGTKFQG
IQYAFNRKKVKDHGEGGIIVGASLEDKRVLIIDDVMTAGTAINEAFEIISIAQGRVVG
CIVALDRQEVIHESDPERTSATQSVSKRYNVPVLSIVSLTQVVQFMGNRLSPEQKSAI
ENYRKAYGI"
gene complement(808246..808317)
/gene="CDC65"
/locus_tag="YNCM0036C"
/db_xref="GeneID:855314"
tRNA complement(808246..808317)
/gene="CDC65"
/locus_tag="YNCM0036C"
/product="tRNA-Gln"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:15706032]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:15706032]"
/experiment="EXISTENCE:genetic interaction:GO:0070125
mitochondrial translational elongation [PMID:15706032]"
/experiment="EXISTENCE:mutant phenotype:GO:1900180
regulation of protein localization to nucleus
[PMID:25527290]"
/note="Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE
analysis; can mutate to cause constitutive pseudohyphal
growth in homozygous diploids; required for localization
of transcription factor Gln3p to the nucleus in response
to nitrogen starvation or rapamycin treatment"
/db_xref="GeneID:855314"
/db_xref="SGD:S000006690"
repeat_region complement(808537..808906)
/note="Ty4 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007118"
repeat_region 809000..809233
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007126"
gene complement(<809623..>810777)
/gene="SCS7"
/locus_tag="YMR272C"
/gene_synonym="FAH1"
/db_xref="GeneID:855315"
mRNA complement(<809623..>810777)
/gene="SCS7"
/locus_tag="YMR272C"
/gene_synonym="FAH1"
/product="fatty acid alpha-hydroxylase"
/transcript_id="NM_001182779.1"
/db_xref="GeneID:855315"
CDS complement(809623..810777)
/gene="SCS7"
/locus_tag="YMR272C"
/gene_synonym="FAH1"
/EC_number="1.14.18.6"
/EC_number="1.14.18.7"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0006673
inositol phosphoceramide metabolic process [PMID:9559540]"
/experiment="EXISTENCE:mutant phenotype:GO:0000038 very
long-chain fatty acid metabolic process [PMID:9353282]"
/experiment="EXISTENCE:mutant phenotype:GO:0000170
sphingosine hydroxylase activity [PMID:9353282]"
/experiment="EXISTENCE:mutant phenotype:GO:0006673
inositol phosphoceramide metabolic process
[PMID:16652392|PMID:9353282|PMID:9368039|PMID:9559540]"
/experiment="EXISTENCE:mutant phenotype:GO:0080132 fatty
acid alpha-hydroxylase activity
[PMID:9353282|PMID:9559540]"
/note="Sphingolipid alpha-hydroxylase; functions in the
alpha-hydroxylation of sphingolipid-associated very long
chain fatty acids, has both cytochrome b5-like and
hydroxylase/desaturase domains, not essential for growth"
/codon_start=1
/product="fatty acid alpha-hydroxylase"
/protein_id="NP_013999.1"
/db_xref="GeneID:855315"
/db_xref="SGD:S000004885"
/translation="MSTNTSKTLELFSKKTVQEHNTANDCWVTYQNRKIYDVTRFLSE
HPGGDESILDYAGKDITEIMKDSDVHEHSDSAYEILEDEYLIGYLATDEEAARLLTNK
NHKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILR
SDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALK
NMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPM
DKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKL
PPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYE"
gene <811089..>811196
/locus_tag="YMR272W-B"
/db_xref="GeneID:1466507"
mRNA <811089..>811196
/locus_tag="YMR272W-B"
/product="uncharacterized protein"
/transcript_id="NM_001184617.1"
/db_xref="GeneID:1466507"
CDS 811089..811196
/locus_tag="YMR272W-B"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/note="hypothetical protein; identified by gene-trapping,
microarray-based expression analysis, and genome-wide
homology searching; SWAT-GFP fusion protein localizes to
the endoplasmic reticulum and vacuole, while mCherry
fusion localizes to just the vacuole"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878149.1"
/db_xref="GeneID:1466507"
/db_xref="SGD:S000028696"
/translation="MRSLVFVQLSLLSWEIFCGERSFVSMKAIFSCMYV"
gene complement(<811233..>813980)
/gene="ZDS1"
/locus_tag="YMR273C"
/gene_synonym="CES1; CKM1; NRC1; OSS1"
/db_xref="GeneID:855316"
mRNA complement(<811233..>813980)
/gene="ZDS1"
/locus_tag="YMR273C"
/gene_synonym="CES1; CKM1; NRC1; OSS1"
/product="Zds1p"
/transcript_id="NM_001182780.1"
/db_xref="GeneID:855316"
CDS complement(811233..813980)
/gene="ZDS1"
/locus_tag="YMR273C"
/gene_synonym="CES1; CKM1; NRC1; OSS1"
/experiment="EXISTENCE:direct assay:GO:0000131 incipient
cellular bud site [PMID:8816439]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:21536748]"
/experiment="EXISTENCE:direct assay:GO:0005934 cellular
bud tip [PMID:8816439]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:21536748]"
/experiment="EXISTENCE:genetic interaction:GO:0004864
protein phosphatase inhibitor activity [PMID:18762578]"
/experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA
export from nucleus [PMID:15619606]"
/experiment="EXISTENCE:genetic interaction:GO:0010971
positive regulation of G2/M transition of mitotic cell
cycle [PMID:20980617]"
/experiment="EXISTENCE:genetic interaction:GO:0030010
establishment of cell polarity [PMID:8816439]"
/experiment="EXISTENCE:mutant phenotype:GO:0004864 protein
phosphatase inhibitor activity [PMID:18762578]"
/experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA
export from nucleus [PMID:15619606]"
/experiment="EXISTENCE:mutant phenotype:GO:0010971
positive regulation of G2/M transition of mitotic cell
cycle [PMID:21536748]"
/experiment="EXISTENCE:mutant phenotype:GO:0030010
establishment of cell polarity [PMID:8816439]"
/experiment="EXISTENCE:mutant phenotype:GO:0031507
heterochromatin formation [PMID:10662670]"
/experiment="EXISTENCE:mutant phenotype:GO:0032880
regulation of protein localization [PMID:18762578]"
/experiment="EXISTENCE:physical interaction:GO:0006406
mRNA export from nucleus [PMID:15619606]"
/note="Protein with a role in regulating Swe1p-dependent
polarized growth; involved in maintaining Cdc55p in the
cytoplasm where it promotes mitotic entry; involved in
mitotic exit through Cdc14p regulation; interacts with
silencing proteins at telomeres; has a role in Bcy1p
localization; implicated in mRNA nuclear export; ZDS1 has
a paralog, ZDS2, that arose from the whole genome
duplication"
/codon_start=1
/product="Zds1p"
/protein_id="NP_014000.1"
/db_xref="GeneID:855316"
/db_xref="SGD:S000004886"
/translation="MSNRDNESMLRTTSSDKAIASQRDKRKSEVLIAAQSLDNEIRSV
KNLKRLSIGSMDLLIDPELDIKFGGESSGRRSWSGTTSSSASMPSDTTTVNNTRYSDP
TPLENLHGRGNSGIESSNKTKQGNYLGIKKGVHSPSRKLNANVLKKNLLWVPANQHPN
VKPDNFLELVQDTLQNIQLSDNGEDNDGNSNENNDIEDNGEDKESQSYENKENNTINL
NRGLSRHGNASLIRRPSTLRRSYTEFDDNEDDDNKGDSASETVNKVEERISKIKERPV
SLRDITEELTKISNSAGLTDNDAITLARTLSMAGSYSDKKDQPQPEGHYDEGDIGFST
SQANTLDDGEFASNMPINNTMTWPERSSLRRSRFNTYRIRSQEQEKEVEQSVDEMKND
DEERLKLTKNTIKVEIDPHKSPFRQQDEDSENMSSPGSIGDFQDIYNHYRQSSGEWEQ
EMGIEKEAEEVPVKVRNDTVEQDLELREGTTDMVKPSATDDNKETKRHRRRNGWTWLN
NKMSREDDNEENQGDDENEENVDSQRMELDNSKKHYISLFNGGEKTEVSNKEEMNNSS
TSTATSQTRQKIEKTFANLFRRKPHHKHDASSSPSSSPSSSPSIPNNDAVHVRVRKSK
KLGNKSGREPVEPIVLRNRPRPHRHHHSRHGSQKISVKTLKDSQPQQQIPLQPQLEGA
IEIEKKEESDSESLPQLQPAVSVSSTKSNSRDREEEEAKKKNKKRSNTTEISNQQHSK
HVQKENTDEQKAQLQAPAQEQVQTSVPVQASAPVQNSAPVQTSAPVEASAQTQAPAAP
PLKHTSILPPRKLTFADVKKPDKPNSPVQFTDSAFGFPLPLLTVSTVIMFDHRLPINV
ERAIYRLSHLKLSNSKRGLREQVLLSNFMYAYLNLVNHTLYMEQVAHDKEQQQQQQQQ
P"
gene complement(<814364..>815311)
/gene="RCE1"
/locus_tag="YMR274C"
/db_xref="GeneID:855317"
mRNA complement(<814364..>815311)
/gene="RCE1"
/locus_tag="YMR274C"
/product="CAAX prenyl protease"
/transcript_id="NM_001182781.1"
/db_xref="GeneID:855317"
CDS complement(814364..815311)
/gene="RCE1"
/locus_tag="YMR274C"
/experiment="EXISTENCE:direct assay:GO:0004222
metalloendopeptidase activity [PMID:17942791]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:9736709]"
/experiment="EXISTENCE:genetic interaction:GO:0071432
peptide mating pheromone maturation involved in positive
regulation of conjugation with cellular fusion
[PMID:10825201|PMID:11581258|PMID:9065405]"
/experiment="EXISTENCE:genetic interaction:GO:0071586
CAAX-box protein processing [PMID:9065405]"
/experiment="EXISTENCE:mutant phenotype:GO:0071432 peptide
mating pheromone maturation involved in positive
regulation of conjugation with cellular fusion
[PMID:10825201]"
/experiment="EXISTENCE:mutant phenotype:GO:0071586
CAAX-box protein processing [PMID:16361710|PMID:9065405]"
/note="Type II CAAX prenyl protease; involved in the
proteolysis and maturation of Ras and the a-factor mating
pheromone"
/codon_start=1
/product="CAAX prenyl protease"
/protein_id="NP_014001.1"
/db_xref="GeneID:855317"
/db_xref="SGD:S000004887"
/translation="MLQFSTFLVLLYISISYVLPLYATSQPEGSKRDNPRTIKSRMQK
LTIMLISNLFLVPFLQSQLSSTTSHISFKDAFLGLGIIPGYYAALPNPWQFSQFVKDL
TKCVAMLLTLYCGPVLDFVLYHLLNPKSSILEDFYHEFLNIWSFRNFIFAPITEEIFY
TSMLLTTYLNLIPHSQLSYQQLFWQPSLFFGLAHAHHAYEQLQEGSMTTVSILLTTCF
QILYTTLFGGLTKFVFVRTGGNLWCCIILHALCNIMGFPGPSRLNLHFTVVDKKAGRI
SKLVSIWNKCYFALLVLGLISLKDTLQTLVGTPGYRITL"
rep_origin 815342..815567
/note="ARS1330; Autonomously Replicating Sequence"
/db_xref="SGD:S000118380"
gene complement(<815651..>818581)
/gene="BUL1"
/locus_tag="YMR275C"
/gene_synonym="DAG1; RDS1; SMM2"
/db_xref="GeneID:855318"
mRNA complement(<815651..>818581)
/gene="BUL1"
/locus_tag="YMR275C"
/gene_synonym="DAG1; RDS1; SMM2"
/product="ubiquitin-ubiquitin ligase BUL1"
/transcript_id="NM_001182782.1"
/db_xref="GeneID:855318"
CDS complement(815651..818581)
/gene="BUL1"
/locus_tag="YMR275C"
/gene_synonym="DAG1; RDS1; SMM2"
/experiment="EXISTENCE:direct assay:GO:0000151 ubiquitin
ligase complex [PMID:9931424]"
/experiment="EXISTENCE:genetic interaction:GO:0000001
mitochondrion inheritance [PMID:10366593]"
/experiment="EXISTENCE:genetic interaction:GO:0034450
ubiquitin-ubiquitin ligase activity [PMID:11352928]"
/experiment="EXISTENCE:genetic interaction:GO:0070086
ubiquitin-dependent endocytosis [PMID:29514933]"
/experiment="EXISTENCE:mutant phenotype:GO:0000209 protein
polyubiquitination [PMID:8668140]"
/experiment="EXISTENCE:mutant phenotype:GO:0006513 protein
monoubiquitination [PMID:8668140]"
/experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP
export [PMID:26585826]"
/note="Alpha-arrestin, component of the Rsp5p E3-ubiquitin
ligase complex; ubiquitin-binding adaptor involved in
down-regulation of general amino acid transporter Gap1p
upon shift to preferred nitrogen source; involved in
lactate transporter Jen1p endocytosis; BUL1 has a paralog,
BUL2, that arose from the whole genome duplication"
/codon_start=1
/product="ubiquitin-ubiquitin ligase BUL1"
/protein_id="NP_014002.1"
/db_xref="GeneID:855318"
/db_xref="SGD:S000004888"
/translation="MAKDLNDSGFPPKRKPLLRPQRSDFTANSSTTMNVNANTRGRGR
QKQEGGKGSSRSPSLHSPKSWIRSASATGILGLRRPELAHSHSHAPSTGTPAGGNRSP
LRRSTANATPVETGRSLTDGDINNVVDVLPSFEMYNTLHRHIPQGNVDPDRHDFPPSY
QEANNSTATGAAGSSADLSHQSLSTDALGATRSSSTSNLENLIPLRTEHHSIAAHQST
AVDEDSLDIPPILDDLNDTDNIFIDKLYTLPKMSTPIEITIKTTKHAPIPHVKPEEES
ILKEYTSGDLIHGFITIENKSQANLKFEMFYVTLESYISIIDKVKSKRTIKRFLRMVD
LSASWSYSKIALGSGVDFIPADVDYDGSVFGLNNSRVLEPGVKYKKFFIFKLPLQLLD
VTCKQEHFSHCLLPPSFGIDKYRNNCKYSGIKVNRVLGCGHLGTKGSPILTNDMSDDN
LSINYTIDARIVGKDQKASKLYIMKEREYNLRVIPFGFDANVVGERTTMSQLNDITKL
VQERLDALRKIFQRLEKKEPITNRDIHGADLSGTIDDSIESDSQEILQRKLDQLHIKN
RNNYLVNYNDLKLGHDLDNGRSGNSGHNTDTSRAWGPFVESELKYKLKNKSNSSSFLN
FSHFLNSSSSSMSSSSNAGKNNHDLTGNKERTGLILVKAKIPKQGLPYWAPSLLRKTN
VFESKSKHDQENWVRLSELIPEDVKKPLEKLDLQLTCIESDNSLPHDPPEIQSITTEL
ICITAKSDNSIPIKLNSELLMNKEKLTSIKALYDDFHSKICEYETKFNKNFLELNELY
NMNRGDRRPKELKFTDFITSQLFNDIESICNLKVSVHNLSNIFKKQVSTLKQHSKHAL
SEDSISHTGNGSSSSPSSASLTPVTSSSKSSLFLPSGSSSTSLKFTDQIVHKWVRIAP
LQYKRDINVNLEFNKDIKETLIPSFESCLCCRFYCVRVMIKFENHLGVAKIDIPISVR
QVTK"
gene <818827..>819948
/gene="DSK2"
/locus_tag="YMR276W"
/db_xref="GeneID:855319"
mRNA <818827..>819948
/gene="DSK2"
/locus_tag="YMR276W"
/product="ubiquitin domain-containing protein DSK2"
/transcript_id="NM_001182783.1"
/db_xref="GeneID:855319"
CDS 818827..819948
/gene="DSK2"
/locus_tag="YMR276W"
/experiment="EXISTENCE:curator inference:GO:0005634
nucleus [PMID:8070654]"
/experiment="EXISTENCE:direct assay:GO:0036435 K48-linked
polyubiquitin modification-dependent protein binding
[PMID:28525741]"
/experiment="EXISTENCE:genetic interaction:GO:0030474
spindle pole body duplication [PMID:8070654]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:15167887]"
/experiment="EXISTENCE:mutant phenotype:GO:0030674
protein-macromolecule adaptor activity [PMID:11805328]"
/experiment="EXISTENCE:mutant phenotype:GO:0072665 protein
localization to vacuole [PMID:29444958]"
/note="Nuclear-enriched ubiquitin-like
polyubiquitin-binding protein; K48-Ub chain binding
protein that also binds K63-linked chains in vitro;
required for spindle pole body (SPB) duplication and for
transit through the G2/M phase of the cell cycle; involved
in proteolysis; interacts with the proteasome; contains an
N-terminal Ub-like (UBL) and a C-terminal Ub-associated
(UBA) domain; protein abundance increases in response to
DNA replication stress"
/codon_start=1
/product="ubiquitin domain-containing protein DSK2"
/protein_id="NP_014003.1"
/db_xref="GeneID:855319"
/db_xref="SGD:S000004889"
/translation="MSLNIHIKSGQDKWEVNVAPESTVLQFKEAINKANGIPVANQRL
IYSGKILKDDQTVESYHIQDGHSVHLVKSQPKPQTASAAGANNATATGAAAGTGATPN
MSSGQSAGFNPLADLTSARYAGYLNMPSADMFGPDGGALNNDSNNQDELLRMMENPIF
QSQMNEMLSNPQMLDFMIQSNPQLQAMGPQARQMLQSPMFRQMLTNPDMIRQSMQFAR
MMDPNAGMGSAGGAASAFPAPGGDAPEEGSNTNTTSSSNTGNNAGTNAGTNAGANTAA
NPFASLLNPALNPFANAGNAASTGMPAFDPALLASMFQPPVQASQAEDTRPPEERYEH
QLRQLNDMGFFDFDRNVAALRRSGGSVQGALDSLLNGDV"
gene <820256..>822454
/gene="FCP1"
/locus_tag="YMR277W"
/db_xref="GeneID:855320"
mRNA <820256..>822454
/gene="FCP1"
/locus_tag="YMR277W"
/product="protein serine/threonine phosphatase"
/transcript_id="NM_001182784.1"
/db_xref="GeneID:855320"
CDS 820256..822454
/gene="FCP1"
/locus_tag="YMR277W"
/EC_number="3.1.3.16"
/experiment="EXISTENCE:direct assay:GO:0004722 protein
serine/threonine phosphatase activity
[PMID:10445027|PMID:11904169]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:genetic interaction:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:10445027|PMID:12370301]"
/experiment="EXISTENCE:mutant phenotype:GO:0004722 protein
serine/threonine phosphatase activity [PMID:10445027]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:10445027]"
/note="Carboxy-terminal domain (CTD) phosphatase;
essential for dephosphorylation of the repeated C-terminal
domain of the RNA polymerase II large subunit (Rpo21p);
relocalizes to the cytosol in response to hypoxia"
/codon_start=1
/product="protein serine/threonine phosphatase"
/protein_id="NP_014004.1"
/db_xref="GeneID:855320"
/db_xref="SGD:S000004890"
/translation="MTTQIRSPQGLPYPIQIDKLIPSVGSYLHEGDRLLVYKFWYLVE
RASDTGDDDNEHDVSPGGSAGSNGVSPPTKQLRESIEFFESPYEGDLISWNVDVGDEV
ATANQVICEIKRPCNHDIVYGGLCTQCGKEVSADAFDGVPLDVVGDVDLQISETEAIR
TGKALKEHLRRDKKLILVVDLDQTIIHCGVDPTIAEWKNDPNNPNFETLRDVKSFTLD
EELVLPLMYMNDDGSMLRPPPVRKCWYYVKVRPGLKEFFAKVAPLFEMHIYTMATRAY
ALQIAKIVDPTGELFGDRILSRDENGSLTTKSLAKLFPTDQSMVVVIDDRGDVWNWCP
NLIKVVPYNFFVGVGDINSNFLPKQSTGMLQLGRKTRQKSQESQELLTDIMDNEKKLQ
EKIDKEVKRQEEKLNHQLATAEEPPANESKEELTKKLEYSASLEVQQQNRPLAKLQKH
LHDQKLLVDDDDELYYLMGTLSNIHKTYYDMLSQQNEPEPNLMEIIPSLKQKVFQNCY
FVFSGLIPLGTDIQRSDIVIWTSTFGATSTPDIDYLTTHLITKNPSTYKARLAKKFNP
QIKIVHPDWIFECLVNWKKVDEKPYTLIVDSPISDEELQNFQTQLQKRQEYLEETQEQ
QHMLTSQENLNLFAAGTSWLNNDDDEDIPDTASDDDEDDDHDDESDDENNSEGIDRKR
SIEDNHDDTSQKKTKAEPSQDGPVQHKGEGDDNEDSDSQLEEELMDMLDD"
gene <822763..>824631
/gene="PRM15"
/locus_tag="YMR278W"
/gene_synonym="PGM3"
/db_xref="GeneID:855321"
mRNA <822763..>824631
/gene="PRM15"
/locus_tag="YMR278W"
/gene_synonym="PGM3"
/product="phosphoribomutase PRM15"
/transcript_id="NM_001182785.1"
/db_xref="GeneID:855321"
CDS 822763..824631
/gene="PRM15"
/locus_tag="YMR278W"
/gene_synonym="PGM3"
/EC_number="5.4.2.7"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0008973
phosphopentomutase activity [PMID:23103740]"
/experiment="EXISTENCE:mutant phenotype:GO:0006148 inosine
catabolic process [PMID:23670538]"
/experiment="EXISTENCE:mutant phenotype:GO:0006166 purine
ribonucleoside salvage [PMID:23670538]"
/experiment="EXISTENCE:mutant phenotype:GO:0008973
phosphopentomutase activity [PMID:23103740|PMID:23670538]"
/experiment="EXISTENCE:mutant phenotype:GO:0046115
guanosine catabolic process [PMID:23670538]"
/note="Phosphoribomutase; catalyzes interconversion of
ribose-1-phosphate and ribose-5-phosphate; has some
phosphoglucomutase activity but primary activity in vivo
is phosphoribomutase; contributes to ribose recycling in
the pentose phosphate pathway; transcription induced in
response to stress; green fluorescent protein (GFP)-fusion
protein localizes to the cytoplasm and nucleus;
non-essential"
/codon_start=1
/product="phosphoribomutase PRM15"
/protein_id="NP_014005.1"
/db_xref="GeneID:855321"
/db_xref="SGD:S000004891"
/translation="MLQGILETVPSDLKDPISLWFKQDRNPKTIEEVTALCKKSDWNE
LHKRFDSRIQFGTAGLRSQMQAGFSRMNTLVVIQASQGLATYVRQQFPDNLVAVVGHD
HRFHSKEFARATAAAFLLKGFKVHYLNPDHEFVHTPLVPFAVDKLKASVGVMITASHN
PKMDNGYKVYYSNGCQIIPPHDHAISDSIDANLEPWANVWDFDDVLNKALKQGKLMYS
REEMLKLYLEEVSKNLVEINPLKLEVKAKPWFVYTPMHGVGFDIFSTIVKKTLCLVEG
KDYLCVPEQQNPDPSFPTVGFPNPEEKGALDIGINLAEKHDIDLLVANDPDADRFSVA
VKDMQSGEWRQLTGNEIGFLFAFYEYQKYKSMDKEFQHVHPLAMLNSTVSSQMIKKMA
EIEGFHYEDTLTGFKWIGNRAILLEKKGYYVPFGFEEAIGYMFPAMEHDKDGISASIV
FLQAYCKWKIDHNLDPLNVLENGFKKYGVFKEYNGYYVVPNPTVTKDIFDYIRNVYTP
EGASYPSSIGEEIEVLYYRDLTTGYQSDTINHKPTLPVDPTSQMITVSARPSNGSENE
HIRFTIRGSGTEPKLKVYIEACANEEQRASFLAKLTWNVLRREWFRPDEMNIVTKF"
gene complement(<824729..>826351)
/gene="ATR2"
/locus_tag="YMR279C"
/db_xref="GeneID:855322"
mRNA complement(<824729..>826351)
/gene="ATR2"
/locus_tag="YMR279C"
/product="Atr2p"
/transcript_id="NM_001182786.1"
/db_xref="GeneID:855322"
CDS complement(824729..826351)
/gene="ATR2"
/locus_tag="YMR279C"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0035445 borate
transmembrane transport [PMID:21621519]"
/note="Putative boron transporter involved in boron efflux
and resistance; overexpression mutant but not null mutant
displays boron tolerance phenotype; identified as a
heat-induced gene in a high-throughout screen; YMR279C is
not an essential gene; YMR279C has a paralog, ATR1, that
arose from the whole genome duplication"
/codon_start=1
/product="Atr2p"
/protein_id="NP_014006.1"
/db_xref="GeneID:855322"
/db_xref="SGD:S000004892"
/translation="MFSIFKKKTSVQGTDSEIDEKITVKAKDKVVVSTEDEEVTTIVS
STKSTQVTNDSPWQDPTYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFN
SEANNQAWLMASFPLAAGSFILISGRLGDIYGLKKMLIVGYVIVIVWSIISGLSKYSN
SDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGGMFGGL
FGGLIVTEDPNQWPWVFYAFGIATFLSLLMAWYSIPNNVPTNIHGLSMDWTGSALAII
GLILFNFVWNQAPIVGWDKPYIIVLLIISVIFLVAFFVYESKYAEVPLLPRAMTKNRH
MIMILLAVFLGWGSFGIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSMAAFFVAFS
IKRLGPALLLCFSLMAFDAGSIMFSVLPVEQSYWKLNFAMQAILCFGMDLSFPASSII
LSDGLPMQYQGMAGSLVNTVINYSASLCLGMGGTVEHQINKSGNDLLKGYRAAVYLGV
GLASLGVVISVTYMLENLWNRHRKSEDRSLEA"
gene complement(<827028..>831329)
/gene="CAT8"
/locus_tag="YMR280C"
/gene_synonym="DIL1; MSP8"
/db_xref="GeneID:855323"
mRNA complement(<827028..>831329)
/gene="CAT8"
/locus_tag="YMR280C"
/gene_synonym="DIL1; MSP8"
/product="DNA-binding transcription factor CAT8"
/transcript_id="NM_001182787.1"
/db_xref="GeneID:855323"
CDS complement(827028..831329)
/gene="CAT8"
/locus_tag="YMR280C"
/gene_synonym="DIL1; MSP8"
/experiment="EXISTENCE:direct assay:GO:0000978 RNA
polymerase II cis-regulatory region sequence-specific DNA
binding [PMID:10540293|PMID:11405098|PMID:14685767]"
/experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding
transcription activator activity, RNA polymerase
II-specific [PMID:14685767]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:11024040|PMID:7891685|PMID:8710504]"
/experiment="EXISTENCE:mutant phenotype:GO:0061414
positive regulation of transcription from RNA polymerase
II promoter by a nonfermentable carbon source
[PMID:10540293|PMID:10628872|PMID:11024040|PMID:7891685|PM
ID:8710504|PMID:9894915]"
/note="Zinc cluster transcriptional activator; necessary
for derepression of a variety of genes under
non-fermentative growth conditions, active after diauxic
shift, binds carbon source responsive elements; relative
distribution to the nucleus increases upon DNA replication
stress"
/codon_start=1
/product="DNA-binding transcription factor CAT8"
/protein_id="NP_014007.1"
/db_xref="GeneID:855323"
/db_xref="SGD:S000004893"
/translation="MANNNSDRQGLEPRVIRTLGSQALSGPSISNRTSSSEANPHFSK
NVKEAMIKTASPTPLSTPIYRIAQACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDK
LLRKAYPKGYTESLEERVRELEAENKRLLALCDIKEQQISLVSQSRPQTSTDNTINGN
FKHDLKDAPLNLSSTNIYLLNQTVNKQLQNGKMDGDNSGSAMSPLGAPPPPPHKDHLC
DGVSCTNHLHVKPTSTSLNDPTAISFEQDEAPGLPAVKALKSMTTHQRSTQLATLVSL
SIPRSTEEILFIPQLLTRIRQIFGFNSKQCLYTVSLLSSLKNRLPAPRLLAPSTSTKL
KEKDEDKKLDDDSAFVKRFQSTNLSEFVDLKKFLISLKFNINSFSKQSEKPANDQDDE
LLSLTEIKELLHLFFKFWSNQVPILNNDHFLIYFNNFVEVVKHLSTENLETNNTTKST
VTTNHEIFALKLLMMLQMGLLVKIKMEKIKYTVPKNPKAKYARLMAYYHQLSLIIPKN
PYFLNMSTTSLPSLQLLSLASFYYLNVGDISAIYGVRGRIVSMAQQLRLHRCPSAVLS
VHSNPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFDIECALPISDVEYKDQ
LSMENEKADKKAKKIQLQGQVSSFSLQIIRFAKILGNILDSIFKRGMMDERITSEVAL
VHENALDNWRNQLPEMYYFQITVNGTVNLDEIRATNQRNTETKFDKKDIILFEKKILL
LFYFLAKSMIHLPVIATKPLPKNVDNATKKKQSMFNNDSKGATNQDHMILDVDMTSPA
IRTSSSYIILQQATNATLTIFQAINSMYLPLPLNVSRTLIRFSLLCARGSLEYTKGGA
LFLDNKNLLLDTIKDIENDRLLDLPGIASWHTLKLFDMSINLLLKAPNVKVERLDKFL
EKKLNYYNRLMGLPPATTTSLKPLFGSQSKNSLENRQRTPNVKRENPEHEYLYGNDSN
NNNNSEAGHSPMTNTTNGNKRLKYEKDAKRNAKDGGISKGENAHNFQNDTKKNMSTSN
LFPFSFSNTDLTALFTHPEGPNCTNTNNGNVDVCNRASTDATDANIENLSFLNMAPFL
QTGNSNIGQNTIENKPMHMDAIFSLPSNLDLMKDNMDSKPEQLEPVIKQNPENSKNNQ
FHQKGKSTNMEKNNLSFNNKSNYSLTKLMRLLNNDNSFSNISINNFLYQNDQNSASAD
PGTNKKAVTNAGANFKPPSTGSNTSQGSILGSTKHGMDNCDFNDLGNFNNFMTNVNYS
GVDYDYIVDASLGLAPLLVDTPDISNTNTTSTTSNRSKNSIILDTTFNDDLDRSRMNA
REVLNPTDSILSQGMVSSVSTRNTSNQRSLSSGNDSKGDSSSQENSKSATGNQLDTPS
TLFQMRRTSSGPSASHRGPRRPQKNRYNTDRSKSSGGGSSNTDNVSDLFQWQNAK"
gene <832339..>833253
/gene="GPI12"
/locus_tag="YMR281W"
/db_xref="GeneID:855324"
mRNA <832339..>833253
/gene="GPI12"
/locus_tag="YMR281W"
/product="N-acetylglucosaminylphosphatidylinositol
deacetylase"
/transcript_id="NM_001182788.1"
/db_xref="GeneID:855324"
CDS 832339..833253
/gene="GPI12"
/locus_tag="YMR281W"
/EC_number="3.5.1.89"
/experiment="EXISTENCE:direct assay:GO:0000225
N-acetylglucosaminylphosphatidylinositol deacetylase
activity [PMID:10085243]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/note="ER membrane protein involved in the second step of
GPI anchor assembly; the second step is the
de-N-acetylation of the
N-acetylglucosaminylphosphatidylinositol intermediate;
functional homolog of human PIG-Lp; GPI stands for
glycosylphosphatidylinositol"
/codon_start=1
/product="N-acetylglucosaminylphosphatidylinositol
deacetylase"
/protein_id="NP_014008.1"
/db_xref="GeneID:855324"
/db_xref="SGD:S000004894"
/translation="MKMLRRTKVNFSKLLYKITKLAIVLTILYIYFTPKIVSRNNASL
QHIFPHKYGDYEINLVIAHPDDEVMFFSPIISQLNSYFPRTVPFNIICLSKGNAEGLG
ETRVRELNESAALLLHNERAVSVQVMDFQDGMDEIWDIDSITSSLSQKIDIKNHNLNQ
IIVTFDSYGVSNHINHKSCYAAVKKLVDDYAQPKTKRNEQPPHVTALYLRSYKNNIVL
KYNSFIWEILKILYDLISPFRRIIQALPPNTAAEKDKLSLMNTHAQYVLAFATMLNAH
ESQVVWFRYGWWIFSRFVFVNEFDVYTY"
gene complement(<833356..>835098)
/gene="AEP2"
/locus_tag="YMR282C"
/gene_synonym="ATP13"
/db_xref="GeneID:855325"
mRNA complement(<833356..>835098)
/gene="AEP2"
/locus_tag="YMR282C"
/gene_synonym="ATP13"
/product="Aep2p"
/transcript_id="NM_001182789.1"
/db_xref="GeneID:855325"
CDS complement(833356..835098)
/gene="AEP2"
/locus_tag="YMR282C"
/gene_synonym="ATP13"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14576278|PMID:16823961|PMID:24769239|PMID:7635208]"
/experiment="EXISTENCE:genetic interaction:GO:0070124
mitochondrial translational initiation [PMID:10101162]"
/note="Mitochondrial protein; likely involved in
translation of the mitochondrial OLI1 mRNA; exhibits
genetic interaction with the OLI1 mRNA 5'-untranslated
leader"
/codon_start=1
/product="Aep2p"
/protein_id="NP_014009.1"
/db_xref="GeneID:855325"
/db_xref="SGD:S000004895"
/translation="MWINRLVKHPSYSVLRFYTKRLCTVSVKSLREFGVLPNSTICHS
VYPRRTYVMGRAVINDILIKKSYSTHTVCAIDRSKDENNGSAYDKFEAKGIPIDVHTL
KRIISSSGMDESEFSKSISYLFAKTVDPEPKDVLSLEDLSFLLSKLYTQRFQIRRICR
DINAKYSEFWFKLFSLYAEKVDAKRNQVNLRNTKLDACEIFDANLMIKNFIELGQLGK
AQKILSFILDRNPDILLSPKNADISTIVHFLQLRCGALAPYWKIPDNSEQKQGFLRKM
VRLGAKNTSIRLSSTYKAMDHQTLLKIADLALQEKKLLNSEDLLSTLIQSFGHLGQTQ
ILERCIEHIWQISPQEFPSHVVIKHRGCYPSSKILVSILVSFYFNDHDLHRGLSILDS
FIKHYPDVKLDALFWRRLFQLSHFAWTPANDKKATSVVRCWHLMKQWYASKRLRPSVD
YETLRQLYDIMKKTGNFPLGIDVLRSFKPGIERTRAENAGKVNNIIIKYQKCIIKELV
NRGRFSAVREFIDSYGFDRKMTKDLNIFCANRMFLRSKKMKNKIENKKEREKVRLDSF
DDDEDDGMIIGSLW"
gene complement(<835326..>836867)
/gene="RIT1"
/locus_tag="YMR283C"
/db_xref="GeneID:855326"
mRNA complement(<835326..>836867)
/gene="RIT1"
/locus_tag="YMR283C"
/product="tRNA A64-2'-O-ribosylphosphate transferase"
/transcript_id="NM_001182790.1"
/db_xref="GeneID:855326"
CDS complement(835326..836867)
/gene="RIT1"
/locus_tag="YMR283C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0016763
pentosyltransferase activity [PMID:7954819]"
/experiment="EXISTENCE:mutant phenotype:GO:0016763
pentosyltransferase activity [PMID:7954819]"
/experiment="EXISTENCE:mutant phenotype:GO:0019988
charged-tRNA amino acid modification [PMID:7954819]"
/note="Initiator methionine 2'-O-ribosyl phosphate
transferase; modifies the initiator methionine tRNA at
position 64 to distinguish it from elongator methionine
tRNA"
/codon_start=1
/product="tRNA A64-2'-O-ribosylphosphate transferase"
/protein_id="NP_014010.1"
/db_xref="GeneID:855326"
/db_xref="SGD:S000004896"
/translation="MVSRLSKRYRSRVQFSISVMDENIYLSLSQINKDIRKENKSVRN
RLQSILLDNKFLQDRVIPIFPHYPLIPNERCGLWYCNPSSFKQTSYFKSTDGHVNQWD
FSTRRLNFHLLETIRDNKGIIIVDSTRRGKKIPDALSKTVPIWCAVLNTLMLQETEKN
VAIDKVLYLPPETVPKSEYDMIKRKIPELVAKLQKLNIIDSKKLNELFMGKLLRPIWV
HPGSSLLDHSVDYFTGEVQEYEAWETPEDQNIIPIILCTVSYQAQDGMDKRYGFTYVQ
GAADDHELWSFGLDSNMFWAHIEYLGDASYSDDQLHDYIMDLAAAKLRNQCYIQDKGS
LDEVFGNIDKITNEISLGKVSSGLTINKNLKQKLKSEYGKVIIFSNSVTVAEDTDDEE
ESGTDPFISIYKLQSGDKKSSKALRSTFPRIHGEIQSLFTNRDEKIKPMLICCNTGTD
MSIGVILSILCTKYTEEWMLTSELPDISKLIVRKHLTKLISHLKGRNVNPSRATLNSV
NSFLM"
repeat_region 837450..837764
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000007127"
rep_origin 837764..837928
/note="ARS1331; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130192"
gene 837928..838016
/gene="SUP8"
/locus_tag="YNCM0037W"
/db_xref="GeneID:855327"
tRNA join(837928..837966,837981..838016)
/gene="SUP8"
/locus_tag="YNCM0037W"
/product="tRNA-Tyr"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE
analysis; can mutate to suppress ochre nonsense mutations"
/db_xref="GeneID:855327"
/db_xref="SGD:S000006784"
gene <838187..>839995
/gene="YKU70"
/locus_tag="YMR284W"
/gene_synonym="HDF1; NES24"
/db_xref="GeneID:855328"
mRNA <838187..>839995
/gene="YKU70"
/locus_tag="YMR284W"
/gene_synonym="HDF1; NES24"
/product="ATP-dependent DNA helicase YKU70"
/transcript_id="NM_001182791.1"
/db_xref="GeneID:855328"
CDS 838187..839995
/gene="YKU70"
/locus_tag="YMR284W"
/gene_synonym="HDF1; NES24"
/EC_number="3.6.4.12"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:10638763]"
/experiment="EXISTENCE:direct assay:GO:0006325 chromatin
organization [PMID:11553718]"
/experiment="EXISTENCE:direct assay:GO:0043564 Ku70:Ku80
complex [PMID:8754818]"
/experiment="EXISTENCE:direct assay:GO:0070034 telomerase
RNA binding [PMID:12975323]"
/experiment="EXISTENCE:genetic interaction:GO:0000723
telomere maintenance [PMID:10818099|PMID:8604297]"
/experiment="EXISTENCE:genetic interaction:GO:0000727
double-strand break repair via break-induced replication
[PMID:17321803]"
/experiment="EXISTENCE:genetic interaction:GO:0030466
silent mating-type cassette heterochromatin formation
[PMID:18791224]"
/experiment="EXISTENCE:mutant phenotype:GO:0000723
telomere maintenance
[PMID:10818099|PMID:8604297|PMID:9501103]"
/experiment="EXISTENCE:mutant phenotype:GO:0000724
double-strand break repair via homologous recombination
[PMID:11016833]"
/experiment="EXISTENCE:mutant phenotype:GO:0000727
double-strand break repair via break-induced replication
[PMID:17321803]"
/experiment="EXISTENCE:mutant phenotype:GO:0006303
double-strand break repair via nonhomologous end joining
[PMID:10908335|PMID:9501103]"
/experiment="EXISTENCE:mutant phenotype:GO:0030466 silent
mating-type cassette heterochromatin formation
[PMID:18791224]"
/experiment="EXISTENCE:mutant phenotype:GO:0031509
subtelomeric heterochromatin formation
[PMID:9501103|PMID:26587833]"
/experiment="EXISTENCE:mutant phenotype:GO:0097552
mitochondrial double-strand break repair via homologous
recombination [PMID:22214610]"
/experiment="EXISTENCE:mutant phenotype:GO:0097695
establishment of protein-containing complex localization
to telomere [PMID:15531893]"
/note="Subunit of the telomeric Ku complex
(Yku70p-Yku80p); involved in telomere length maintenance,
structure and telomere position effect; required for
localization of telomerase ribonucleoprotein to nucleus
via interaction with the TLC1 guide RNA; relocates to
sites of double-strand cleavage to promote nonhomologous
end joining during DSB repair"
/codon_start=1
/product="ATP-dependent DNA helicase YKU70"
/protein_id="NP_014011.1"
/db_xref="GeneID:855328"
/db_xref="SGD:S000004897"
/translation="MRSVTNAFGNSGELNDQVDETGYRKFDIHEGILFCIELSETMFK
ESSDLEYKSPLLEILESLDELMSQLVITRPGTAIGCYFYYCNREDAKEGIYELFPLRD
INATFMKKLNDLLEDLSSGRISLYDYFMFQQTGSEKQVRLSVLFTFMLDTFLEEIPGQ
KQLSNKRVFLFTDIDKPQEAQDIDERARLRRLTIDLFDNKVNFATFFIGYADKPFDNE
FYSDILQLGSHTNENTGLDSEFDGPSTKPIDAKYIKSRILRKKEVKRIMFQCPLILDE
KTNFIVGVKGYTMYTHEKAGVRYKLVYEHEDIRQEAYSKRKFLNPITGEDVTGKTVKV
YPYGDLDINLSDSQDQIVMEAYTQKDAFLKIIGFRSSSKSIHYFNNIDKSSFIVPDEA
KYEGSIRTLASLLKILRKKDKIAILWGKLKSNSHPSLYTLSPSSVKDYNEGFYLYRVP
FLDEIRKFPSLLSYDDGSEHKLDYDNMKKVTQSIMGYFNLRDGYNPSDFKNPLLQKHY
KVLHDYLLQIETTFDENETPNTKKDRMMREDDSLRKLYYIRNKILESEKSEDPIIQRL
NKYVKIWNMFYKKFNDDNISIKEEKKPFDKKPKFNI"
gene complement(<840144..>841691)
/gene="NGL2"
/locus_tag="YMR285C"
/db_xref="GeneID:855329"
mRNA complement(<840144..>841691)
/gene="NGL2"
/locus_tag="YMR285C"
/product="RNA exonuclease"
/transcript_id="NM_001182792.1"
/db_xref="GeneID:855329"
CDS complement(840144..841691)
/gene="NGL2"
/locus_tag="YMR285C"
/experiment="EXISTENCE:curator inference:GO:0005737
cytoplasm [PMID:12358428]"
/experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA
endonuclease activity [PMID:12358428]"
/experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA
processing [PMID:12358428]"
/note="Protein involved in 5.8S rRNA processing;
Ccr4p-like RNase required for correct 3'-end formation of
5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog,
NGL3, that arose from the whole genome duplication"
/codon_start=1
/product="RNA exonuclease"
/protein_id="NP_014012.1"
/db_xref="GeneID:855329"
/db_xref="SGD:S000004898"
/translation="MTQDKEVKVVAPDVAPDQEVEINKSVKDAKHQTNDDSLLQHKKK
GKKGKKSKPIVTPEHIAKVRAEREVMRKAKRDAMLAQGVDPDCPPELHFIRRPFLSLH
EAEPVTGFRFKLMTYNCLAQALIRRKLFPDSGDALKWYRRSKVLLNEFKYYNSDVICL
QEIDHIQFQSFWKDEFSKLGYDGQYYRNATKNHGVAIMWRRELFHQVDKMLIDYDKES
SESISTRTTTNNVGLVLALKFSEKVLSNLGKKSSKKCGILIGTTHLFWHPFGTYERTR
QCYIVLKKMKEFMHRVNVLQNENDGDLSHWFPFFCGDFNSQPFDTPYLSMTSKPVHYR
NRAKTVIGCSTSYKFSKVRDGEEGADDEEGGNIEKYGKDQPESPVPEKFHANEEQSEL
VDKMAQLHNSLDMRAISLYSVGYKNVHPENAGLDNDRGEPEISNWANTWRGLLDYLFY
VKKWDPQSNCQEVETLGDFEKENKVKCRGFLRMPPGNEMTKHGQPHVGEYASDHLSMV
CDLELQL"
gene <841942..>842202
/gene="MRPL33"
/locus_tag="YMR286W"
/gene_synonym="uL30m"
/db_xref="GeneID:855330"
mRNA <841942..>842202
/gene="MRPL33"
/locus_tag="YMR286W"
/gene_synonym="uL30m"
/product="mitochondrial 54S ribosomal protein YmL33"
/transcript_id="NM_001182793.1"
/db_xref="GeneID:855330"
CDS 841942..842202
/gene="MRPL33"
/locus_tag="YMR286W"
/gene_synonym="uL30m"
/experiment="EXISTENCE:curator inference:GO:0032543
mitochondrial translation [PMID:2060626]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:2060626]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005762
mitochondrial large ribosomal subunit [PMID:2060626]"
/note="Mitochondrial ribosomal protein of the large
subunit"
/codon_start=1
/product="mitochondrial 54S ribosomal protein YmL33"
/protein_id="NP_014013.1"
/db_xref="GeneID:855330"
/db_xref="SGD:S000004899"
/translation="MVFYKVTLSRSLIGVPHTTKSIVKSLGLGKRGSIVYKKVNPAIA
GSLAKVKELVKVEVTEHELTPSQQRELRKSNPGFIVEKRTID"
gene complement(<842436..>845345)
/gene="DSS1"
/locus_tag="YMR287C"
/gene_synonym="MSU1"
/db_xref="GeneID:855331"
mRNA complement(<842436..>845345)
/gene="DSS1"
/locus_tag="YMR287C"
/gene_synonym="MSU1"
/product="exoribonuclease II"
/transcript_id="NM_001182794.1"
/db_xref="GeneID:855331"
CDS complement(842436..845345)
/gene="DSS1"
/locus_tag="YMR287C"
/gene_synonym="MSU1"
/EC_number="3.1.13.1"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0008859
exoribonuclease II activity [PMID:17658549|PMID:12426313]"
/experiment="EXISTENCE:direct assay:GO:0045025
mitochondrial degradosome [PMID:12426313]"
/experiment="EXISTENCE:mutant phenotype:GO:0000957
mitochondrial RNA catabolic process
[PMID:12426313|PMID:9829834]"
/note="3'-5' exoribonuclease; component of the
mitochondrial degradosome along with the ATP-dependent RNA
helicase Suv3p; the degradosome associates with the
ribosome and mediates turnover of aberrant or unprocessed
RNAs"
/codon_start=1
/product="exoribonuclease II"
/protein_id="NP_014014.1"
/db_xref="GeneID:855331"
/db_xref="SGD:S000004900"
/translation="MVVRRKVHVLLIARSFHSYTPCFRVTTRGKRQRSKSKQQAKVEL
DHTRELDNDQATETVVDRSVGPEKDIESINKDFLQRTKGLEPDIELKQLPQIKQEFNQ
RYKDRYVKPSEDWYVNSWRSLTKPKIPLYKLINSDFQLITKLKAPNPMEFQPVQLMES
PLNVGDFVLLKMRPNELAMCVSLPSSTMDPRYTFVTIDGTMCFATKNRVLLRIPHKLP
AGIHSLIQPESHHKHLPIGTVKNFSNQTNILPIVARQLITSRYPAQISKLAWKDLPIT
TKKLQLLHRSLQNYMGPWQIPFFTLVGLVQKLDLNKALDDKNGINYLTSLVNNYHTVN
DIPINSPTFVSTYWAIMQQQESNLWGEIHLNTALLSPISVTIIPLKSQHLYYAQVIEK
LEANSYREVNKFVKLVNERKYRDISALYPSVIQLLKDFAAGNFHNNGIIVALISKIFR
KIERYKDCDITRDICQDLINEITPNSIPNPLLLNMDLALPASSKLVKWQQKLYDLTNI
EELQWKKSGTDDDRYDFGDLRVFCIDSETAHEIDDGVSVKNYGRDGLYTLYIHIADPT
SMFPESTNVDIEGISTDILNVALKRSFTTYLPDTVVPMLPQSICHLSDLGKQGQRTKT
ISFSVDVKITSKCSGKSIEIMYDSFKIRKGIVSNFPKATYEDVDRILGTPNSEASPVK
KDLESLSMISKLLREQRIKNSNAVIFGEGFNKGLVMLNADSEGELTEVTFSDQEETLS
TILVSEMMILANTLTGRYFAENKIGGVFRCYKQLPLGEVAQQQYDSMITSTKKGIFPK
LKDIVKLSSLLNSSFYTGRPFRHEMIGAKQYLTVTSPLRRFPDLINHLQIHRHLQKKP
LCFNQTQIDSLIWPIQSRADILKRASRNSSTYWTLNYLKKLTKLEPERTFDVMVTSVP
QNGFTGCVFPDLSFARGTLKLHPSSMHYPMIGDIVKNCKISKIDCLEGMLELEKL"
gene <845571..>848486
/gene="HSH155"
/locus_tag="YMR288W"
/db_xref="GeneID:855332"
mRNA <845571..>848486
/gene="HSH155"
/locus_tag="YMR288W"
/product="U2 snRNP complex subunit HSH155"
/transcript_id="NM_001182795.1"
/db_xref="GeneID:855332"
CDS 845571..848486
/gene="HSH155"
/locus_tag="YMR288W"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:12773561]"
/experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP
[PMID:15565172|PMID:16314500]"
/experiment="EXISTENCE:direct assay:GO:0071004 U2-type
prespliceosome [PMID:16618970]"
/experiment="EXISTENCE:physical interaction:GO:0000245
spliceosomal complex assembly [PMID:10688664]"
/experiment="EXISTENCE:physical interaction:GO:0000398
mRNA splicing, via spliceosome [PMID:16314500]"
/note="U2-snRNP associated splicing factor; forms
extensive associations with the branch site-3' splice
site-3' exon region upon prespliceosome formation;
similarity to the mammalian U2 snRNP-associated splicing
factor SAP155"
/codon_start=1
/product="U2 snRNP complex subunit HSH155"
/protein_id="NP_014015.1"
/db_xref="GeneID:855332"
/db_xref="SGD:S000004901"
/translation="MSHPIQFVNANNSDKSHQLGGQYSIPQDLRENLQKEAARIGENE
KDVLQEKMETRTVQNREDSYHKRRFDMKFEPDSDTQTVTSSENTQDAVVPRKRKSRWD
VKGYEPPDESSTAVKENSDSALVNVEGIHDLMFFKPSDHKYFADVISKKPIDELNKDE
KKERTLSMLLLKIKNGNTASRRTSMRILTDKAVTFGPEMIFNRLLPILLDRSLEDQER
HLMIKTIDRVLYQLGDLTKPYVHKILVVAAPLLIDEDPMVRSTGQEIITNLSTVAGLK
TILTVMRPDIENEDEYVRNVTSRAAAVVAKALGVNQLLPFINAACHSRKSWKARHTGI
KIVQQIGILLGIGVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTLSTLAENSYPYGIEV
FNVVLEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEAMRIIRREFDSPD
DEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFWVRRVALDRPLNKVVTYTTVT
LAKKLGCSYTIDKLLTPLRDEAEPFRTMAVHAVTRTVNLLGTADLDERLETRLIDALL
IAFQEQTNSDSIIFKGFGAVTVSLDIRMKPFLAPIVSTILNHLKHKTPLVRQHAADLC
AILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPI
NQILPTLTPILRNKHRKVEVNTIKFVGLIGKLAPTYAPPKEWMRICFELLELLKSTNK
EIRRSANATFGFIAEAIGPHDVLVALLNNLKVQERQLRVCTAVAIGIVAKVCGPYNVL
PVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKDYIYFITPLLEDALTDRDLVHRQT
ASNVITHLALNCSGTGHEDAFIHLMNLLIPNIFETSPHAIMRILEGLEALSQALGPGL
FMNYIWAGLFHPAKNVRKAFWRVYNNMYVMYQDAMVPFYPVTPDNNEEYIEELDLVL"
gene <848685..>849809
/gene="ABZ2"
/locus_tag="YMR289W"
/db_xref="GeneID:855333"
mRNA <848685..>849809
/gene="ABZ2"
/locus_tag="YMR289W"
/product="aminodeoxychorismate lyase ABZ2"
/transcript_id="NM_001182796.1"
/db_xref="GeneID:855333"
CDS 848685..849809
/gene="ABZ2"
/locus_tag="YMR289W"
/EC_number="4.1.3.38"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0008696
4-amino-4-deoxychorismate lyase activity [PMID:17873082]"
/experiment="EXISTENCE:mutant phenotype:GO:0046656 folic
acid biosynthetic process [PMID:17873082]"
/note="Aminodeoxychorismate lyase
(4-amino-4-deoxychorismate lyase); catalyzes the third
step in para-aminobenzoic acid biosynthesis; involved in
folic acid biosynthesis"
/codon_start=1
/product="aminodeoxychorismate lyase ABZ2"
/protein_id="NP_014016.1"
/db_xref="GeneID:855333"
/db_xref="SGD:S000004902"
/translation="MSLMDNWKTDMESYDEGGLVANPNFEVLATFRYDPGFARQSASK
KEIFETPDPRLGLRDEDIRQQIINEDYSSYLRVREVNSGGDLLENIQHPDAWKHDCKT
IVCQRVEDMLQVIYERFFLLDEQYQRIRIALSYFKIDFSTSLNDLLKLLVENLINCKE
GNSEYHEKIQKMINERQCYKMRVLVSKTGDIRIEAIPMPMEPILKLTTDYDSVSTYFI
KTMLNGFLIDSTINWDVVVSSEPLNASAFTSFKTTSRDHYARARVRMQTAINNLRGSE
PTSSVSQCEILFSNKSGLLMEGSITNVAVIQKDPNGSKKYVTPRLATGCLCGTMRHYL
LRLGLIEEGDIDIGSLTVGNEVLLFNGVMGCIKGTVKTKY"
gene complement(<850074..>851591)
/gene="HAS1"
/locus_tag="YMR290C"
/db_xref="GeneID:855335"
mRNA complement(<850074..>851591)
/gene="HAS1"
/locus_tag="YMR290C"
/product="ATP-dependent RNA helicase HAS1"
/transcript_id="NM_001182797.1"
/db_xref="GeneID:855335"
CDS complement(850074..851591)
/gene="HAS1"
/locus_tag="YMR290C"
/EC_number="3.6.4.13"
/experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
[PMID:15718299]"
/experiment="EXISTENCE:direct assay:GO:0003724 RNA
helicase activity [PMID:15718299]"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:10684247]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:10684247|PMID:15049817]"
/experiment="EXISTENCE:direct assay:GO:0008186
ATP-dependent activity, acting on RNA [PMID:15718299]"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:12150911]"
/experiment="EXISTENCE:direct assay:GO:0030687
preribosome, large subunit precursor
[PMID:11583614|PMID:17443350]"
/experiment="EXISTENCE:mutant phenotype:GO:0000462
maturation of SSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15049817]"
/experiment="EXISTENCE:mutant phenotype:GO:0000463
maturation of LSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23788678]"
/experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA
processing [PMID:15242642]"
/experiment="EXISTENCE:mutant phenotype:GO:0042273
ribosomal large subunit biogenesis
[PMID:15049817|PMID:23788678]"
/experiment="EXISTENCE:mutant phenotype:GO:0042274
ribosomal small subunit biogenesis
[PMID:15049817|PMID:23788678]"
/experiment="EXISTENCE:mutant phenotype:GO:1990417 snoRNA
release from pre-rRNA [PMID:16908538]"
/note="ATP-dependent RNA helicase; involved in the
biogenesis of 40S and 60S ribosome subunits; localizes to
both the nuclear periphery and nucleolus; highly enriched
in nuclear pore complex fractions; constituent of 66S
pre-ribosomal particles"
/codon_start=1
/product="ATP-dependent RNA helicase HAS1"
/protein_id="NP_014017.1"
/db_xref="GeneID:855335"
/db_xref="SGD:S000004903"
/translation="MATPSNKRSRDSESTEEPVVDEKSTSKQNNAAPEGEQTTCVEKF
EELKLSQPTLKAIEKMGFTTMTSVQARTIPPLLAGRDVLGAAKTGSGKTLAFLIPAIE
LLHSLKFKPRNGTGIIVITPTRELALQIFGVARELMEFHSQTFGIVIGGANRRQEAEK
LMKGVNMLIATPGRLLDHLQNTKGFVFKNLKALIIDEADRILEIGFEDEMRQIIKILP
NEDRQSMLFSATQTTKVEDLARISLRPGPLFINVVPETDNSTADGLEQGYVVCDSDKR
FLLLFSFLKRNQKKKIIVFLSSCNSVKYYAELLNYIDLPVLELHGKQKQQKRTNTFFE
FCNAERGILICTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGTKGKGKSLM
FLTPNELGFLRYLKASKVPLNEYEFPENKIANVQSQLEKLIKSNYYLHQTAKDGYRSY
LQAYASHSLKTVYQIDKLDLAKVAKSYGFPVPPKVNITIGASGKTPNTKRRKTHK"
gene <852630..>854390
/gene="TDA1"
/locus_tag="YMR291W"
/db_xref="GeneID:855336"
mRNA <852630..>854390
/gene="TDA1"
/locus_tag="YMR291W"
/product="protein kinase TDA1"
/transcript_id="NM_001182799.1"
/db_xref="GeneID:855336"
CDS 852630..854390
/gene="TDA1"
/locus_tag="YMR291W"
/EC_number="2.7.11.1"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity [PMID:16319894]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22289182]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:22289182]"
/experiment="EXISTENCE:direct assay:GO:0006468 protein
phosphorylation [PMID:16319894]"
/experiment="EXISTENCE:mutant phenotype:GO:0004674 protein
serine/threonine kinase activity [PMID:25593311]"
/experiment="EXISTENCE:mutant phenotype:GO:0018105
peptidyl-serine phosphorylation
[PMID:22289182|PMID:25593311]"
/note="Protein kinase of unknown cellular role; green
fluorescent protein (GFP)-fusion protein localizes to the
cytoplasm and nucleus; null mutant is sensitive to
expression of the top1-T722A allele; not an essential
gene; relocalizes from nucleus to cytoplasm upon DNA
replication stress"
/codon_start=1
/product="protein kinase TDA1"
/protein_id="NP_014019.1"
/db_xref="GeneID:855336"
/db_xref="SGD:S000004905"
/translation="MTTASSSASQLQQRLPEEKPWPQLSGSNADAQTFKCKYVTNHNS
LGDGNFSVVKECMNIHTKDLYAMKLIKKQTVKNKIQLIQREFDLLRSISEKIRDMEKK
NEHSLDIFEGHHHILQLFDYFETADNIVLITQLCQKGDLYEKIVENQCLDLETQVTSY
CACLVSVLEFLHSQGIVHRDLKAENVLFRLRVNENEKNLQGEHHGDFKYDLLAHDLVL
ADFGLAAEYNTSKVNSLKEFVGTISYIAPEIVKCKGVGEMTPDQVGKLDKYGCPVDIW
ALGVLTYFMAFGYTPFDCTTDDETLECISKCDYYVDEQMMHDPKYEQFWNFVQCCFTI
DPAVRRSAKNLKQHPFIKDYFATSNSLNTKDTPNFSFHPTIRRVSSTASMHTLRSPSK
SRKTTTLAYLNMDGGSSETSTAFSSKMDLPDLYVDRTINSRERSLNRIRDTLKKTLSM
TSLKPAGTFDYLHANKNGTSLSSSKSGLVKKNSTFVLDPKPPKNSLMNGCFSTTPESR
SNFNTPKTLSRQGSSTSVKKYVNEVDLLLTPRTASMSSNDTTAINDYDTTNDKNPARK
HAASFQVNVDDSDGDETMQI"
gene <854795..>855293
/gene="GOT1"
/locus_tag="YMR292W"
/db_xref="GeneID:855337"
mRNA join(<854795..854816,854899..>855293)
/gene="GOT1"
/locus_tag="YMR292W"
/product="Got1p"
/transcript_id="NM_001182800.1"
/db_xref="GeneID:855337"
CDS join(854795..854816,854899..855293)
/gene="GOT1"
/locus_tag="YMR292W"
/experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis
cisterna [PMID:10406798]"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:10406798]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:19383723]"
/experiment="EXISTENCE:direct assay:GO:0005794 Golgi
apparatus [PMID:19383723]"
/experiment="EXISTENCE:direct assay:GO:0030134
COPII-coated ER to Golgi transport vesicle
[PMID:19383723]"
/experiment="EXISTENCE:genetic interaction:GO:0042147
retrograde transport, endosome to Golgi [PMID:10406798]"
/experiment="EXISTENCE:mutant phenotype:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:19383723|PMID:10406798]"
/note="Homodimeric protein that is packaged into COPII
vesicles; cycles between the ER and Golgi; involved in
secretory transport but not directly required for aspects
of transport assayed in vitro; may influence membrane
composition"
/codon_start=1
/product="Got1p"
/protein_id="NP_014020.1"
/db_xref="GeneID:855337"
/db_xref="SGD:S000004906"
/translation="MWLTEAQKFGVAFTFGGFLFFLFGIFTFFDRALLALGNILFLIG
VFLIIGSQKTYIFFTRPNKRRGSLFFLVGAFLILLKWTFLGFIIESLGIIGLFGDFFG
VIVQFLRSMPIIGPILSHPAIAPIVDKLAGVRVLPV"
gene complement(<855399..>856793)
/gene="HER2"
/locus_tag="YMR293C"
/gene_synonym="GEP6; QRS1; RRG6"
/db_xref="GeneID:855338"
mRNA complement(<855399..>856793)
/gene="HER2"
/locus_tag="YMR293C"
/gene_synonym="GEP6; QRS1; RRG6"
/product="glutamyl-tRNA(Gln) amidotransferase subunit
HER2"
/transcript_id="NM_001182801.1"
/db_xref="GeneID:855338"
CDS complement(855399..856793)
/gene="HER2"
/locus_tag="YMR293C"
/gene_synonym="GEP6; QRS1; RRG6"
/EC_number="6.3.5.7"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:11914276|PMID:14562095|PMID:14576278|PMID:16823961|P
MID:19417106]"
/experiment="EXISTENCE:direct assay:GO:0030956
glutamyl-tRNA(Gln) amidotransferase complex
[PMID:19417106]"
/experiment="EXISTENCE:direct assay:GO:0050567
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
[PMID:19417106]"
/experiment="EXISTENCE:direct assay:GO:0070681
glutaminyl-tRNAGln biosynthesis via transamidation
[PMID:19417106]"
/experiment="EXISTENCE:genetic interaction:GO:0007029
endoplasmic reticulum organization [PMID:18667535]"
/note="Subunit of the trimeric GatFAB
AmidoTransferase(AdT) complex; involved in the formation
of Q-tRNAQ; required for remodeling of ER caused by Hmg2p
overexpression; similar to bacterial GatA glutamyl-tRNA
amidotransferase"
/codon_start=1
/product="glutamyl-tRNA(Gln) amidotransferase subunit
HER2"
/protein_id="NP_014021.1"
/db_xref="GeneID:855338"
/db_xref="SGD:S000004907"
/translation="MPLKRSLKESIERLSSFQSKYNIFTSINPSPYSITNKKGTKETL
TGCVASIKDNIVTKDFPTTCASHILENFKSPFDATVVKLLKQAGVHILGKTNLDEFGM
GSGGVHSIRGPVINPLYPHEDKKIMGGSSSGAAASVACDLVDFALGTDTGGSVRLPAC
YGSVLGFKPSYGRLSRFGVIAYSQSLDTVGILSKKINVLRKVFHTLDKYDMKDPTSLS
VELRELIEGNKKVRRPLKVGIVKEFSHESMPIGFHRLYLSLLEKLINLGLEIYPVSIP
SVKNCLPIYYTLSPAEAASNLSRYDGIRYGYRDSELDIKDGILFAPTRSKFGTEVKNR
IILGNYNLCSDAFKNNFIKAEKLRVNLIDEFDGIFRFPNVLTNSKGNPDGLDLLIVPT
SSKLPGSIRDFEEEEAKSPANSYINDVFTVPMSLAGLPSLSMPLKEKTPIGLQVVGQY
GDDSTVLDFVESIS"
gene <856966..>858087
/gene="JNM1"
/locus_tag="YMR294W"
/gene_synonym="INS1; PAC3"
/db_xref="GeneID:855339"
mRNA <856966..>858087
/gene="JNM1"
/locus_tag="YMR294W"
/gene_synonym="INS1; PAC3"
/product="Jnm1p"
/transcript_id="NM_001182802.1"
/db_xref="GeneID:855339"
CDS 856966..858087
/gene="JNM1"
/locus_tag="YMR294W"
/gene_synonym="INS1; PAC3"
/experiment="EXISTENCE:direct assay:GO:0005200 structural
constituent of cytoskeleton [PMID:9658168]"
/experiment="EXISTENCE:direct assay:GO:0005869 dynactin
complex [PMID:9658168]"
/experiment="EXISTENCE:mutant phenotype:GO:0000132
establishment of mitotic spindle orientation
[PMID:8138567]"
/experiment="EXISTENCE:mutant phenotype:GO:0007097 nuclear
migration [PMID:8138567]"
/note="Component of the yeast dynactin complex; consisting
of Nip100p, Jnm1p, and Arp1p; required for proper nuclear
migration and spindle partitioning during mitotic anaphase
B"
/codon_start=1
/product="Jnm1p"
/protein_id="NP_014022.1"
/db_xref="GeneID:855339"
/db_xref="SGD:S000004908"
/translation="MNVIDLSDPAINVDYDSLIGIDNEESQEIFENEVKEDGQQEEQE
EASSRKDGLIVEPGRDVESLRRAIRDQLLFKIHRQNQSDCADARKLSNDEEDESRQQK
LERIREELEELKIENLTSEMQTEIKELCEIQSKLATESSSRLTNLRKKLLETYEGQDT
VILPNIILDTSNIKRLQKLDQKISLMERFVGIPEALEAEEDRKSVHSKVNELYRSIQL
LQGDDKAEGKLQKFRDRLVELNEEFENSLLGKKIQQDLRLKDDTVSKLVMPENKVKEI
NSMYSMFKQYQDSLPLLAERMKSLNKMNNRVIEVYETTKGLDSQITSIQEQGKVWLKA
LNELDKKFDEQEVKIRENMEQIRRKIDTLEDEALQRNSK"
gene complement(<858297..>858890)
/locus_tag="YMR295C"
/db_xref="GeneID:855341"
mRNA complement(<858297..>858890)
/locus_tag="YMR295C"
/product="uncharacterized protein"
/transcript_id="NM_001182804.1"
/db_xref="GeneID:855341"
CDS complement(858297..858890)
/locus_tag="YMR295C"
/experiment="EXISTENCE:direct assay:GO:0005933 cellular
bud [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0043332 mating
projection tip [PMID:19053807]"
/note="hypothetical protein that associates with
ribosomes; green fluorescent protein (GFP)-fusion protein
localizes to the cell periphery and bud; not an essential
gene; protein abundance increases in response to DNA
replication stress; YMR295C has a paralog, YGR273C, that
arose from the whole genome duplication"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_014024.1"
/db_xref="GeneID:855341"
/db_xref="SGD:S000004910"
/translation="MMHFRKKSSISNTSDHDGANRASDVKISEDDKARLKMRTASVAD
PILDAVQEAQPFEQAADTFHDNMNRQSYFSNEEGHVLCDVFGQPITQADISNPTRARD
ERPLDTIRSFEYAVSGDPVWAQQLETPTYGFRVRPDFPVFGAAVTYDANGMPQQVGGA
SSQMYGEQAVYQPQQHVQTEEKQKKKKKGLFGRMKKK"
gene complement(<859215..>860891)
/gene="LCB1"
/locus_tag="YMR296C"
/gene_synonym="END8; TSC2"
/db_xref="GeneID:855342"
mRNA complement(<859215..>860891)
/gene="LCB1"
/locus_tag="YMR296C"
/gene_synonym="END8; TSC2"
/product="serine C-palmitoyltransferase LCB1"
/transcript_id="NM_001182805.1"
/db_xref="GeneID:855342"
CDS complement(859215..860891)
/gene="LCB1"
/locus_tag="YMR296C"
/gene_synonym="END8; TSC2"
/EC_number="2.3.1.50"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:1556076|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0035339 SPOTS
complex [PMID:20182505]"
/experiment="EXISTENCE:mutant phenotype:GO:0004758 serine
C-palmitoyltransferase activity [PMID:1556076]"
/experiment="EXISTENCE:mutant phenotype:GO:0030148
sphingolipid biosynthetic process [PMID:1556075]"
/note="Component of serine palmitoyltransferase;
responsible along with Lcb2p for the first committed step
in sphingolipid synthesis, which is the condensation of
serine with palmitoyl-CoA to form 3-ketosphinganine"
/codon_start=1
/product="serine C-palmitoyltransferase LCB1"
/protein_id="NP_014025.1"
/db_xref="GeneID:855342"
/db_xref="SGD:S000004911"
/translation="MAHIPEVLPKSIPIPAFIVTTSSYLWYYFNLVLTQIPGGQFIVS
YIKKSHHDDPYRTTVEIGLILYGIIYYLSKPQQKKSLQAQKPNLSPQEIDALIEDWEP
EPLVDPSATDEQSWRVAKTPVTMEMPIQNHITITRNNLQEKYTNVFNLASNNFLQLSA
TEPVKEVVKTTIKNYGVGACGPAGFYGNQDVHYTLEYDLAQFFGTQGSVLYGQDFCAA
PSVLPAFTKRGDVIVADDQVSLPVQNALQLSRSTVYYFNHNDMNSLECLLNELTEQEK
LEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKLKNKYKFRLFVDETFSIGVLGATGRG
LSEHFNMDRATAIDITVGSMATALGSTGGFVLGDSVMCLHQRIGSNAYCFSACLPAYT
VTSVSKVLKLMDSNNDAVQTLQKLSKSLHDSFASDDSLRSYVIVTSSPVSAVLHLQLT
PAYRSRKFGYTCEQLFETMSALQKKSQTNKFIEPYEEEEKFLQSIVDHALINYNVLIT
RNTIVLKQETLPIVPSLKICCNAAMSPEELKNACESVKQSILACCQESNK"
gene <861922..>863520
/gene="PRC1"
/locus_tag="YMR297W"
/gene_synonym="CPY1; LBC1"
/db_xref="GeneID:855343"
mRNA <861922..>863520
/gene="PRC1"
/locus_tag="YMR297W"
/gene_synonym="CPY1; LBC1"
/product="carboxypeptidase C PRC1"
/transcript_id="NM_001182806.1"
/db_xref="GeneID:855343"
CDS 861922..863520
/gene="PRC1"
/locus_tag="YMR297W"
/gene_synonym="CPY1; LBC1"
/EC_number="3.4.16.5"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:14562095|PMID:23708375]"
/experiment="EXISTENCE:direct assay:GO:0000328 fungal-type
vacuole lumen [PMID:29514932]"
/experiment="EXISTENCE:direct assay:GO:0004185 serine-type
carboxypeptidase activity [PMID:8679540]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0046938
phytochelatin biosynthetic process [PMID:17408619]"
/experiment="EXISTENCE:genetic interaction:GO:0004185
serine-type carboxypeptidase activity [PMID:29514932]"
/experiment="EXISTENCE:genetic interaction:GO:0016236
macroautophagy [PMID:29514932]"
/experiment="EXISTENCE:genetic interaction:GO:0031638
zymogen activation [PMID:29514932]"
/experiment="EXISTENCE:mutant phenotype:GO:0004185
serine-type carboxypeptidase activity
[PMID:8679540|PMID:29514932]"
/experiment="EXISTENCE:mutant phenotype:GO:0046938
phytochelatin biosynthetic process [PMID:17408619]"
/note="Vacuolar carboxypeptidase Y (proteinase C, CPY);
broad-specificity C-terminal exopeptidase involved in
non-specific protein degradation in vacuole; involved,
along with functional homolog Prc1p, in vacuolar zymogen
activation, breakdown of autophagic body, and
autophagosome-dependent protein synthesis; role in
phytochelatin synthesis; targeted to vacuole via
Vps10p-dependent endosomal vacuolar protein sorting
pathway; member of serine carboxypeptidase family;
N-glycosylated"
/codon_start=1
/product="carboxypeptidase C PRC1"
/protein_id="NP_014026.1"
/db_xref="GeneID:855343"
/db_xref="SGD:S000004912"
/translation="MKAFTSLLCGLGLSTTLAKAISLQRPLGLDKDVLLQAAEKFGLD
LDLDHLLKELDSNVLDAWAQIEHLYPNQVMSLETSTKPKFPEAIKTKKDWDFVVKNDA
IENYQLRVNKIKDPKILGIDPNVTQYTGYLDVEDEDKHFFFWTFESRNDPAKDPVILW
LNGGPGCSSLTGLFFELGPSSIGPDLKPIGNPYSWNSNATVIFLDQPVNVGFSYSGSS
GVSNTVAAGKDVYNFLELFFDQFPEYVNKGQDFHIAGESYAGHYIPVFASEILSHKDR
NFNLTSVLIGNGLTDPLTQYNYYEPMACGEGGEPSVLPSEECSAMEDSLERCLGLIES
CYDSQSVWSCVPATIYCNNAQLAPYQRTGRNVYDIRKDCEGGNLCYPTLQDIDDYLNQ
DYVKEAVGAEVDHYESCNFDINRNFLFAGDWMKPYHTAVTDLLNQDLPILVYAGDKDF
ICNWLGNKAWTDVLPWKYDEEFASQKVRNWTASITDEVAGEVKSYKHFTYLRVFNGGH
MVPFDVPENALSMVNEWIHGGFSL"
gene <863819..>864271
/gene="LIP1"
/locus_tag="YMR298W"
/db_xref="GeneID:855344"
mRNA <863819..>864271
/gene="LIP1"
/locus_tag="YMR298W"
/product="sphingosine N-acyltransferase subunit LIP1"
/transcript_id="NM_001182807.1"
/db_xref="GeneID:855344"
CDS 863819..864271
/gene="LIP1"
/locus_tag="YMR298W"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:14690591]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14690591|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:15692566]"
/experiment="EXISTENCE:direct assay:GO:0061576 acyl-CoA
ceramide synthase complex [PMID:15692566]"
/experiment="EXISTENCE:mutant phenotype:GO:0046513
ceramide biosynthetic process [PMID:15692566]"
/experiment="EXISTENCE:mutant phenotype:GO:0050291
sphingosine N-acyltransferase activity [PMID:15692566]"
/experiment="EXISTENCE:physical interaction:GO:0046513
ceramide biosynthetic process [PMID:15692566]"
/note="Ceramide synthase subunit; single-span ER membrane
protein associated with Lag1p and Lac1p and required for
ceramide synthase activity, null mutant grows extremely
slowly and is defective in ceramide synthesis"
/codon_start=1
/product="sphingosine N-acyltransferase subunit LIP1"
/protein_id="NP_014027.1"
/db_xref="GeneID:855344"
/db_xref="SGD:S000004913"
/translation="MSQPTPIITTKSAAKPKPKIFNLFRVCFISLLLIAAVEYFKYGT
RINYEWFHCTPIKEPQSGSVIKLWARGGPSCDKRGEYKTIVKRITRDYEPNDEHLSFC
IIENDNVPPVHYPIHEDKGEPGYVAYVGYDTDSELVQELCADSTIYHM"
gene complement(<864412..>865350)
/gene="DYN3"
/locus_tag="YMR299C"
/db_xref="GeneID:855345"
mRNA complement(<864412..>865350)
/gene="DYN3"
/locus_tag="YMR299C"
/product="dynein light intermediate chain"
/transcript_id="NM_001182808.2"
/db_xref="GeneID:855345"
CDS complement(864412..865350)
/gene="DYN3"
/locus_tag="YMR299C"
/experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic
microtubule [PMID:14764870|PMID:15642746]"
/experiment="EXISTENCE:mutant phenotype:GO:0003774
cytoskeletal motor activity [PMID:15642746]"
/experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear
migration along microtubule [PMID:14764870|PMID:15642746]"
/experiment="EXISTENCE:physical interaction:GO:0005868
cytoplasmic dynein complex [PMID:15642746]"
/note="Dynein light intermediate chain (LIC); localizes
with dynein, null mutant is defective in nuclear
migration"
/codon_start=1
/product="dynein light intermediate chain"
/protein_id="NP_014028.2"
/db_xref="GeneID:855345"
/db_xref="SGD:S000004914"
/translation="MDNCNAWDKLLSQNESTINSTETATITAIIYSPSSKTLHQFINI
CFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSK
VRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQ
SVHIDFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDH
IEMVKRSEILIPKGCDSIGLIKTVDERFEPTEVKEQHFLARYMDFIPTIDKIREDRKT
TSGIDLDKLYPLEVFKVNIQEELGKMFAKYRENSRI"
gene complement(<865559..>867091)
/gene="ADE4"
/locus_tag="YMR300C"
/db_xref="GeneID:855346"
mRNA complement(<865559..>867091)
/gene="ADE4"
/locus_tag="YMR300C"
/product="amidophosphoribosyltransferase"
/transcript_id="NM_001182809.1"
/db_xref="GeneID:855346"
CDS complement(865559..867091)
/gene="ADE4"
/locus_tag="YMR300C"
/EC_number="2.4.2.14"
/experiment="EXISTENCE:direct assay:GO:0004044
amidophosphoribosyltransferase activity [PMID:11689683]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0004044
amidophosphoribosyltransferase activity
[PMID:11689683|PMID:6376509]"
/experiment="EXISTENCE:mutant phenotype:GO:0006189 'de
novo' IMP biosynthetic process [PMID:11689683]"
/note="Phosphoribosylpyrophosphate amidotransferase
(PRPPAT); catalyzes first step of the 'de novo' purine
nucleotide biosynthetic pathway; also known as
amidophosphoribosyltransferase"
/codon_start=1
/product="amidophosphoribosyltransferase"
/protein_id="NP_014029.1"
/db_xref="GeneID:855346"
/db_xref="SGD:S000004915"
/translation="MCGILGIVLANQTTPVAPELCDGCIFLQHRGQDAAGIATCGSRG
RIYQCKGNGMARDVFTQQRVSGLAGSMGIAHLRYPTAGSSANSEAQPFYVNSPYGINL
AHNGNLVNTASLKRYMDEDVHRHINTDSDSELLLNIFAAELEKHNKYRVNNEDVFHAL
EGVYRLCRGGYACVGLLAGFALFGFRDPNGIRPLLFGERENPDGTKDYMLASESVVFK
AHNFTKYRDLKPGEAVIIPKNCSKGEPEFKQVVPINSYRPDLFEYVYFARPDSVLDGI
SVYHTRLAMGSKLAENILKQLKPEDIDVVIPVPDTARTCALECANVLGKPYREGFVKN
RYVGRTFIMPNQRERVSSVRRKLNPMESEFKGKKVLIVDDSIVRGTTSKEIVNMAKES
GATKVYFASAAPAIRYNHIYGIDLTDTKNLIAYNRTDEEVAEVIGCERVIYQSLEDLI
DCCKTDKITKFEDGVFTGNYVTGVEDGYIQELEEKRESIANNSSDMKAEVDIGLYNCA
DY"
gene complement(<867555..>869627)
/gene="ATM1"
/locus_tag="YMR301C"
/db_xref="GeneID:855347"
mRNA complement(<867555..>869627)
/gene="ATM1"
/locus_tag="YMR301C"
/product="ATP-binding cassette Fe/S cluster precursor
transporter ATM1"
/transcript_id="NM_001182810.1"
/db_xref="GeneID:855347"
CDS complement(867555..869627)
/gene="ATM1"
/locus_tag="YMR301C"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:7828591]"
/experiment="EXISTENCE:direct assay:GO:0042626
ATPase-coupled transmembrane transporter activity
[PMID:16754360]"
/experiment="EXISTENCE:mutant phenotype:GO:0016226
iron-sulfur cluster assembly [PMID:10406803]"
/experiment="EXISTENCE:mutant phenotype:GO:0042626
ATPase-coupled transmembrane transporter activity
[PMID:7828591]"
/experiment="EXISTENCE:mutant phenotype:GO:1902497
iron-sulfur cluster transmembrane transport
[PMID:31040179]"
/note="Mitochondrial inner membrane ATP-binding cassette
(ABC) transporter; exports mitochondrially synthesized
precursors of iron-sulfur (Fe/S) clusters to the cytosol;
human homolog ABCB7 can complement yeast null mutant"
/codon_start=1
/product="ATP-binding cassette Fe/S cluster precursor
transporter ATM1"
/protein_id="NP_014030.1"
/db_xref="GeneID:855347"
/db_xref="SGD:S000004916"
/translation="MLLLPRCPVIGRIVRSKFRSGLIRNHSPVIFTVSKLSTQRPLLF
NSAVNLWNQAQKDITHKKSVEQFSSAPKVKTQVKKTSKAPTLSELKILKDLFRYIWPK
GNNKVRIRVLIALGLLISAKILNVQVPFFFKQTIDSMNIAWDDPTVALPAAIGLTILC
YGVARFGSVLFGELRNAVFAKVAQNAIRTVSLQTFQHLMKLDLGWHLSRQTGGLTRAM
DRGTKGISQVLTAMVFHIIPISFEISVVCGILTYQFGASFAAITFSTMLLYSIFTIKT
TAWRTHFRRDANKADNKAASVALDSLINFEAVKYFNNEKYLADKYNGSLMNYRDSQIK
VSQSLAFLNSGQNLIFTTALTAMMYMGCTGVIGGNLTVGDLVLINQLVFQLSVPLNFL
GSVYRDLKQSLIDMETLFKLRKNEVKIKNAERPLMLPENVPYDITFENVTFGYHPDRK
ILKNASFTIPAGWKTAIVGSSGSGKSTILKLVFRFYDPESGRILINGRDIKEYDIDAL
RKVIGVVPQDTPLFNDTIWENVKFGRIDATDEEVITVVEKAQLAPLIKKLPQGFDTIV
GERGLMISGGEKQRLAIARVLLKNARIMFFDEATSALDTHTEQALLRTIRDNFTSGSR
TSVYIAHRLRTIADADKIIVLDNGRVREEGKHLELLAMPGSLYRELWTIQEDLDHLEN
ELKDQQEL"
gene complement(<870073..>872625)
/gene="YME2"
/locus_tag="YMR302C"
/gene_synonym="PRP12; RNA12"
/db_xref="GeneID:855348"
mRNA complement(<870073..>872625)
/gene="YME2"
/locus_tag="YMR302C"
/gene_synonym="PRP12; RNA12"
/product="Yme2p"
/transcript_id="NM_001182811.1"
/db_xref="GeneID:855348"
CDS complement(870073..872625)
/gene="YME2"
/locus_tag="YMR302C"
/gene_synonym="PRP12; RNA12"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:8649384]"
/experiment="EXISTENCE:mutant phenotype:GO:0000002
mitochondrial genome maintenance [PMID:8514129]"
/note="Integral inner mitochondrial membrane protein; role
in maintaining mitochondrial nucleoid structure and
number; mutants exhibit an increased rate of mitochondrial
DNA escape; shows some sequence similarity to
exonucleases"
/codon_start=1
/product="Yme2p"
/protein_id="NP_014031.1"
/db_xref="GeneID:855348"
/db_xref="SGD:S000004917"
/translation="MLLVRTTSLNVSRMPVPCLARGIGILKGKYRLANLMNAQPSVRH
VSSEIQQKDQQAGESNTATDTGVIHKSDEETLIYFDNVYARTTSVWNPTLWYNLLLRN
QSRDAVREKIRNLASPPNNPIYGLELKSTIPVKRDGGVFATFVVPPKYTKAQVNSLIQ
QNTARESSKNLLSYFTRASAFPVKGSPWIEDLRRLPSTTIVIKFQGPALTEEEIYSLF
RRYGTIIDIFPPTAANNNVAKVRYRSFRGAISAKNCVSGIEIHNTVLHIQYENIRRGH
LVSNFFTNHTRIAIPVLFALLSIFAVLVFDPIREFSIEQKITHKYSLSWDNKFWKQLK
TLTSSTMTSIKYYWGGPDDNHQRKHLWEERIEKVNDLKMWLEENNNTFVVIRGPRGSG
KHDLVMQHTLQNRANVLYLDCDKLIKSRTDPMFLKNAASQLGYFPIFPWIDSVTGVLD
LTVQGLTGQKTGLSETKESRFRNMLTTSLMSIRRIALKNYKAFVSTGDGTVNVKEEDY
LQQHPEAKPVIVIDRFEGKSEINGFVYKELSDWAAMLVQMNIAHVIFLTETVASNQRL
SESLPNQVFKNLILSDASKENSRNYVLSQLEDYLYYNKKSKGENVKEPESEKETAENN
DSDSEADTSVKKAEVILNEKELQEIDASLEPLGGRMLDLQAFVRRVKSGEEPSEAVDK
MIEQASEQITQMFLSDKIDSNKSAQAWELIELLSANPVIPFHEIVNKPLFKAAPETGI
MELENNGLITVSRDRGVLQEIRPAKPLYRAAFTYLINDPELAKVLKTRYLLKVVGFET
GRIKKWEEELKPLGKVPDQKLFKTRLDYLSGKINASNAVITKCEEEIKNLSK"
gene complement(<873291..>874337)
/gene="ADH2"
/locus_tag="YMR303C"
/gene_synonym="ADR2"
/db_xref="GeneID:855349"
mRNA complement(<873291..>874337)
/gene="ADH2"
/locus_tag="YMR303C"
/gene_synonym="ADR2"
/product="alcohol dehydrogenase ADH2"
/transcript_id="NM_001182812.1"
/db_xref="GeneID:855349"
CDS complement(873291..874337)
/gene="ADH2"
/locus_tag="YMR303C"
/gene_synonym="ADR2"
/EC_number="1.1.1.1"
/experiment="EXISTENCE:direct assay:GO:0004022 alcohol
dehydrogenase (NAD+) activity [PMID:3546317]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006067 ethanol
metabolic process [PMID:3546317]"
/experiment="EXISTENCE:direct assay:GO:0006116 NADH
oxidation [PMID:3546317]"
/experiment="EXISTENCE:genetic interaction:GO:0000947
amino acid catabolic process to alcohol via Ehrlich
pathway [PMID:12499363]"
/note="Glucose-repressible alcohol dehydrogenase II;
catalyzes the conversion of ethanol to acetaldehyde;
involved in the production of certain carboxylate esters;
regulated by ADR1"
/codon_start=1
/product="alcohol dehydrogenase ADH2"
/protein_id="NP_014032.1"
/db_xref="GeneID:855349"
/db_xref="SGD:S000004918"
/translation="MSIPETQKAIIFYESNGKLEHKDIPVPKPKPNELLINVKYSGVC
HTDLHAWHGDWPLPTKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACE
YCELGNESNCPHADLSGYTHDGSFQEYATADAVQAAHIPQGTDLAEVAPILCAGITVY
KALKSANLRAGHWAAISGAAGGLGSLAVQYAKAMGYRVLGIDGGPGKEELFTSLGGEV
FIDFTKEKDIVSAVVKATNGGAHGIINVSVSEAAIEASTRYCRANGTVVLVGLPAGAK
CSSDVFNHVVKSISIVGSYVGNRADTREALDFFARGLVKSPIKVVGLSSLPEIYEKME
KGQIAGRYVVDTSK"
gene <874987..>878679
/gene="UBP15"
/locus_tag="YMR304W"
/db_xref="GeneID:855350"
mRNA <874987..>878679
/gene="UBP15"
/locus_tag="YMR304W"
/product="ubiquitin-specific protease UBP15"
/transcript_id="NM_001182814.1"
/db_xref="GeneID:855350"
CDS 874987..878679
/gene="UBP15"
/locus_tag="YMR304W"
/EC_number="3.4.19.12"
/experiment="EXISTENCE:direct assay:GO:0004843
cysteine-type deubiquitinase activity
[PMID:10527495|PMID:21665945|PMID:21710968|PMID:25877870]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
[PMID:21665945]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:21665945]"
/experiment="EXISTENCE:direct assay:GO:0010995 free
ubiquitin chain depolymerization [PMID:21665945]"
/experiment="EXISTENCE:direct assay:GO:0016579 protein
deubiquitination [PMID:21665945|PMID:25877870]"
/experiment="EXISTENCE:genetic interaction:GO:0016973
poly(A)+ mRNA export from nucleus [PMID:33226341]"
/experiment="EXISTENCE:mutant phenotype:GO:0004843
cysteine-type deubiquitinase activity [PMID:21665945]"
/experiment="EXISTENCE:mutant phenotype:GO:0010995 free
ubiquitin chain depolymerization [PMID:21665945]"
/note="Ubiquitin-specific protease involved in protein
deubiquitination; forms a complex with AAA peroxins Pex1p
and Pex6p; deubiquitinates mono- and polyubiquitinated
forms of Pex5p; deubiquitinates Clb5p, counteracting APC
activity, and facilitating both Clb5p accumulation and S
phase entry; physically interacts with anaphase-promoting
complex/cyclosome (APC/C) activator, Cdh1p; catalytic
activity regulated by an N-terminal TRAF-like domain and
and C-terminal sequences"
/codon_start=1
/product="ubiquitin-specific protease UBP15"
/protein_id="NP_014033.1"
/db_xref="GeneID:855350"
/db_xref="SGD:S000004920"
/translation="MSSEDELGSIGTVFPGSPIDKSIGSILPQFDEEVETLLEDSFTW
NIPDWNELTNPKYNSPRFRIGDFEWDILLFPQGNHNKGVAVYLEPHPEEKLDETTGEM
VPVDPDWYCCAQFAIGISRPGNGDTINLINKSHHRFNALDTDWGFANLIDLNNLKHPS
KGRPLSFLNEGTLNITAYVRILKDPTGVLWHNFLNYDSKKVTGYVGFRNQGATCYLNS
LLQSYFFTKYFRKLVYEIPTEHESPNNSVPLALQRAFYQLQVSDIPLDTLELTRSFGW
DTAESFTQHDVQELNRILMDRLENNMKGTPVEGKLNEIFVGKMKSYIKCINVDYESAR
VEDFWDLQLNVKNFKNLQESFDNYIEMELMNGENQYAAQDYGLQDAQKGVIFESFPPV
LHLQLKRFEYDFNYDQMVKVNDKYEFPETIDLSPFVDKDVLKKTLDSENKDKNPYVYN
LHGVLVHSGDISTGHYYTLIKPGVEDQWYRFDDERVWRVTKKQVFQENFGCDRLPDEK
VRTMTRGEYQNYIIQRHTSAYMLVYIRQEQEEDLLRPVLESDVPKHVITRVREEIKER
ETKEKEIREAHLYVTLRLHSIKEFIHYEGFDYFAHDGFRLFAEELNDSGLQQINLKVL
RTTKLSDIFASIKETMNIPQERDVKYWKMDYRRNSTLRLTQPINFESVNITLQEALKK
EKKRTMQTQYGEEGVASTEEDDKALLETVSFLDLFIEEPYLELQFLNKLKEASLISKA
QLDDELISTIRTNLPELTKGGIEPVFATDNKSNLLFVKSYDPHTQKLLGFGHFAVNQL
QQLSDISAIIEDSISSNEKLTFYEEVQPGTINEIYMKETIYDADIDTGDIVSFEVPGA
VLPDTFPVYATIKDFYSYLRYRVKLKFSKFDGSSEEYGVSNEIPESFEFWISAYAPYD
DLARMVSKYAHVKPEYLKIIALYSNGRFVLKSTSLLNDYLLKDFNCDQIPPFAFEVLS
VPLKELERLRPIKLYWLKNSYIHYQCFEFEVANDYTESQFLEKVQHKIGFTDEEKENI
LLWTNTNFQFQGLLSDQNTFKDVSKHSLLFGRILPEESKLFKELNRLENVQTSSLEDF
MDDENATDRPMDDEQDLGMAIEHSEDMKGRIVVVQQYFKDLENRHGISFLFNLIPDET
FPKTKDRLHAKFGLGQKEFSKIKLSIGYSTEEGTVFRSLQGFSDEELDKVILYDIMSN
LDYIYMDHPDRLRSHSSYDRPMIIKN"
gene complement(<879063..>880232)
/gene="SCW10"
/locus_tag="YMR305C"
/db_xref="GeneID:855352"
mRNA complement(<879063..>880232)
/gene="SCW10"
/locus_tag="YMR305C"
/product="putative family 17 glucosidase"
/transcript_id="NM_001182815.1"
/db_xref="GeneID:855352"
CDS complement(879063..880232)
/gene="SCW10"
/locus_tag="YMR305C"
/experiment="EXISTENCE:direct assay:GO:0005576
extracellular region [PMID:19129178]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
cell wall [PMID:15781460|PMID:9748433]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0000747
conjugation with cellular fusion [PMID:9748433]"
/note="Cell wall protein with similarity to glucanases;
may play a role in conjugation during mating based on
mutant phenotype and its regulation by Ste12p; SWC10 has a
paralog, SCW4, that arose from the whole genome
duplication"
/codon_start=1
/product="putative family 17 glucosidase"
/protein_id="NP_014035.1"
/db_xref="GeneID:855352"
/db_xref="SGD:S000004921"
/translation="MRFSNFLTVSALLTGALGAPAVRHKHEKRDVVTATVHAQVTVVV
SGNSGETIVPVNENAVVATTSSTAVASQATTSTLEPTTSANVVTSQQQTSTLQSSEAA
STVGSSTSSSPSSSSSTSSSASSSASSSISASGAKGITYSPYNDDGSCKSTAQVASDL
EQLTGFDNIRLYGVDCSQVENVLQAKTSSQKLFLGIYYVDKIQDAVDTIKSAVESYGS
WDDITTVSVGNELVNGGSATTTQVGEYVSTAKSALTSAGYTGSVVSVDTFIAVINNPD
LCNYSDYMAVNAHAYFDENTAAQDAGPWVLEQIERVYTACGGKKDVVITETGWPSKGD
TYGEAVPSKANQEAAISSIKSSCGSSAYLFTAFNDLWKDDGQYGVEKYWGILSSD"
gene <881159..>886516
/gene="FKS3"
/locus_tag="YMR306W"
/db_xref="GeneID:855353"
mRNA <881159..>886516
/gene="FKS3"
/locus_tag="YMR306W"
/product="putative 1,3-beta-D-glucan synthase"
/transcript_id="NM_001182817.1"
/db_xref="GeneID:855353"
CDS 881159..886516
/gene="FKS3"
/locus_tag="YMR306W"
/EC_number="2.4.1.34"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0030476
ascospore wall assembly [PMID:17158736]"
/note="Protein involved in spore wall assembly; has
similarity to 1,3-beta-D-glucan synthase catalytic
subunits Fks1p and Gsc2p; the authentic, non-tagged
protein is detected in highly purified mitochondria in
high-throughput studies"
/codon_start=1
/product="putative 1,3-beta-D-glucan synthase"
/protein_id="NP_014036.1"
/db_xref="GeneID:855353"
/db_xref="SGD:S000004923"
/translation="MDFMSPKFSLTDVEYPAWCQDDEVPITMQEIREIFVELMDKFGF
QKSSMENMYQHLMGQLDSRASRTGAQNALVSLHVSYIGGEHANYRKWYFAAQLDLDEE
IGFQNMRLHGKARQRNVKMAKKRGVSIKEQIKQWNEKEQEFINNHPKITLTQEQLEDQ
TNLKSADYKWKLKMKKLTPENMIRQLALYLLCWGEANQVRFAPECLCFIFKCALDYDI
STSSSEKTVKSPEYSYLNDVITPLYEFLRGQVYKKDAKGNWKRREKDHKNIIGYDDIN
QLFWYPEGFERIILNNGERLVDKPLEERYLYFKDVAWSKVFYKTYRETRSWKHCFTNF
NRFWIIHFAPFWFFTTFNSPTLYTKNYIQLLNNQPTPQVRLSVIAFGGTIACLVQILA
TVFEWGFVPREWPGAQHLSSRMIGLLFCLAINLGPSVYVLGFFEWDVHSKSAYIVSIV
QLIIAFLTTFFFAVRPLGGLFRPYLNKDKKHRRYISSQTFTASFPKLTGRSKWFSYGL
WVFVYLAKYIESYFFLTLSLRDPIRVLSIMDLSRCQGEYLLGPILCKWQAKITLVLML
LSDLGLFFLDTYLWYIICNCIFSIVLSFSLGTSILTPWKNVYSRLPKRIYSKILATSE
MDVKFKAKILISQVWNAIVISMYREHLLSIEHLQRLLFQQVDSLMGDTRTLKSPTFFV
AQDDSTFKSMEFFPSNSEAKRRISFFAQSLATPISEPVPVDCMPTFTVLVPHYSEKIL
LGLKEIIREESPKSKITVLEYLKHLHPTEWECFVKDTKLLSMEKSFLKEAESSHDEDR
LEIPDALYDPRSSPLSDHTESRKLPTEDDLIKEKINDLPFSYFGFNSSEPSYTLRTRI
WASLRTQTLYRTLSGFMNYSKAIKLLYRIENPSLVSLYRGNNEALENDLENMASRKFR
MVVAMQRYAKFNKDEVEATELLLRAYPNMFISYLLEELEQNESEKTYYSCLTNGYAEF
DEESGLRKPIFKIRLSGNPILGDGKSDNQNHSIIFYRGEYIQVIDANQDNYLEECLKI
RSVLSEFEELELNPTIPYIPGIEYEEEPPPIAIVGSREYIFSENIGVLGDIAAGKEQT
FGTLFARTLAEIGGKLHYGHPDFLNGIFMTTRGGLSKAQRGLHLNEDIYAGMNAICRG
GKIKHSDYYQCGKGRDLGFGSILNFTTKIGAGMGEQLLSREYYYLGTQLPMDRFLSFF
YAHPGFHLNNLFISFSVQLFFVLLLNLGALNHEIIACFYDKDAPITNLETPVGCYNIQ
PALHWVSIFVLSIFIVFFIAFAPLLIQEVLEKGIWRAASRFLHHLLSMAPLFEVFVCQ
VYSNSLLMDLTFGGAKYISTGRGFAITRLDFFTLYSRFVNISIYSGFQVFFMLLFAII
SMWQPALLWFWITVISMCFAPFIFNPHQFAFMDFFIDYKTFIHWLFSGNTKYQKESWA
NFVKSSRSRFTGYKSKTVDDISEDSGHDSKKARFWNVFFAELFLPFCVFLFNFTAFSF
INAQTGVSDSTPTSAVFRLLLVTFLPIFLNSIVLFLLFWVSLFVVPGLSYCCKDAGAV
IAFIAHTFSVLVYLLDFELMWFLQGWNFTRTLILLITCINMHLILFKVFTTIFLTREY
KNNKAHLAWWNGKWYNTGMGWSIILQPIREYFVKIMESSYFAADFFLGHFLLFIQTPI
ILLPFIDYWHTMVLFWMNPRSIIAHKRILTRKQRALRSRIVSKYFSLYFVMLGVLLFM
LIAPFFAGDFVSSPQELLEGTLFEGIFQPNNQNNNDTGPNAPSTILTTTPTLPTFRTV
A"
gene <887003..>888682
/gene="GAS1"
/locus_tag="YMR307W"
/gene_synonym="CWH52; GGP1"
/db_xref="GeneID:855355"
mRNA <887003..>888682
/gene="GAS1"
/locus_tag="YMR307W"
/gene_synonym="CWH52; GGP1"
/product="1,3-beta-glucanosyltransferase GAS1"
/transcript_id="NM_001182818.1"
/db_xref="GeneID:855355"
CDS 887003..888682
/gene="GAS1"
/locus_tag="YMR307W"
/gene_synonym="CWH52; GGP1"
/experiment="EXISTENCE:direct assay:GO:0000936 primary
cell septum [PMID:19793924]"
/experiment="EXISTENCE:direct assay:GO:0005621 cellular
bud scar [PMID:19793924]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836|PMID:1824714|PMID:19793924]"
/experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
cell wall [PMID:15781460|PMID:19793924]"
/experiment="EXISTENCE:direct assay:GO:0030134
COPII-coated ER to Golgi transport vesicle
[PMID:18462190]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:19541632]"
/experiment="EXISTENCE:direct assay:GO:0042124
1,3-beta-glucanosyltransferase activity
[PMID:10809732|PMID:15355340|PMID:17397106]"
/experiment="EXISTENCE:direct assay:GO:0045121 membrane
raft [PMID:10716729]"
/experiment="EXISTENCE:genetic interaction:GO:0031505
fungal-type cell wall organization [PMID:16986442]"
/experiment="EXISTENCE:mutant phenotype:GO:0030447
filamentous growth [PMID:15645503]"
/experiment="EXISTENCE:mutant phenotype:GO:0031505
fungal-type cell wall organization [PMID:9515908]"
/experiment="EXISTENCE:mutant phenotype:GO:0031507
heterochromatin formation [PMID:19541632]"
/experiment="EXISTENCE:mutant phenotype:GO:1905897
regulation of response to endoplasmic reticulum stress
[PMID:31275960]"
/experiment="EXISTENCE:physical interaction:GO:0031507
heterochromatin formation [PMID:19541632]"
/note="Beta-1,3-glucanosyltransferase required for cell
wall assembly; also has role in transcriptional silencing;
localizes to cell surface via glycosylphosphatidylinositol
(GPI) anchor, also found at nuclear periphery; genetic
interactions with histone H3 lysine acetyltransferases
GCN5 and SAS3 indicate functions for Gas1p in DNA damage
response and cell cycle regulation; protein demonstrates
amyloid properties in vivo"
/codon_start=1
/product="1,3-beta-glucanosyltransferase GAS1"
/protein_id="NP_014038.1"
/db_xref="GeneID:855355"
/db_xref="SGD:S000004924"
/translation="MLFKSLSKLATAAAFFAGVATADDVPAIEVVGNKFFYSNNGSQF
YIRGVAYQADTANETSGSTVNDPLANYESCSRDIPYLKKLNTNVIRVYAINTTLDHSE
CMKALNDADIYVIADLAAPATSINRDDPTWTVDLFNSYKTVVDTFANYTNVLGFFAGN
EVTNNYTNTDASAFVKAAIRDVRQYISDKNYRKIPVGYSSNDDEDTRVKMTDYFACGD
DDVKADFYGINMYEWCGKSDFKTSGYADRTAEFKNLSIPVFFSEYGCNEVTPRLFTEV
EALYGSNMTDVWSGGIVYMYFEETNKYGLVSIDGNDVKTLDDFNNYSSEINKISPTSA
NTKSYSATTSDVACPATGKYWSAATELPPTPNGGLCSCMNAANSCVVSDDVDSDDYET
LFNWICNEVDCSGISANGTAGKYGAYSFCTPKEQLSFVMNLYYEKSGGSKSDCSFSGS
ATLQTATTQASCSSALKEIGSMGTNSASGSVDLGSGTESSTASSNASGSSSKSNSGSS
GSSSSSSSSSASSSSSSKKNAATNVKANLAQVVFTSIISLSIAAGVGFALV"
gene complement(<888952..>892221)
/gene="PSE1"
/locus_tag="YMR308C"
/gene_synonym="KAP121"
/db_xref="GeneID:855356"
mRNA complement(<888952..>892221)
/gene="PSE1"
/locus_tag="YMR308C"
/gene_synonym="KAP121"
/product="Pse1p"
/transcript_id="NM_001182819.1"
/db_xref="GeneID:855356"
CDS complement(888952..892221)
/gene="PSE1"
/locus_tag="YMR308C"
/gene_synonym="KAP121"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9238021]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:9238021]"
/experiment="EXISTENCE:direct assay:GO:0008139 nuclear
localization sequence binding [PMID:11694505]"
/experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA
export from nucleus [PMID:9238021]"
/experiment="EXISTENCE:mutant phenotype:GO:0006606 protein
import into nucleus [PMID:16651379]"
/experiment="EXISTENCE:mutant phenotype:GO:0007088
regulation of mitotic nuclear division [PMID:14697200]"
/experiment="EXISTENCE:mutant phenotype:GO:0060188
regulation of protein desumoylation [PMID:17403926]"
/experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear
import signal receptor activity [PMID:11274141]"
/experiment="EXISTENCE:physical interaction:GO:0060188
regulation of protein desumoylation [PMID:17403926]"
/experiment="EXISTENCE:physical interaction:GO:0061608
nuclear import signal receptor activity [PMID:11274141]"
/note="Karyopherin/importin that interacts with the
nuclear pore complex; acts as the nuclear import receptor
for specific proteins, including Pdr1p, Yap1p, Ste12p, and
Aft1p; required for stability of the Dam1p-Duo1p complex"
/codon_start=1
/product="Pse1p"
/protein_id="NP_014039.1"
/db_xref="GeneID:855356"
/db_xref="SGD:S000004925"
/translation="MSALPEEVNRTLLQIVQAFASPDNQIRSVAEKALSEEWITENNI
EYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPPSSKLMIMSKNITHIRKEVLAQI
RSSLLKGFLSERADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSF
RILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGI
LLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQIIQFTDMVIKNKD
LEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIES
DDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQMITSTEWRERFAAMMALS
SAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDR
ILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSNKLY
VQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNNKDNSVLKGKCMECATLIGF
AVGKEKFHEHSQELISILVALQNSDIDEDDALRSYLEQSWSRICRILGDDFVPLLPIV
IPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELL
QSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATGTQN
EELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGV
SANLTDTYERMQDRHGDGDEYNENIDEEEDFTDEDLLDEINKSIAAVLKTTNGHYLKN
LENIWPMINTFLLDNEPILVIFALVVIGDLIQYGGEQTASMKNAFIPKVTECLISPDA
RIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDFPGSKLEENRSSTENASAAIA
KILYAYNSNIPNVDTYTANWFKTLPTITDKEAASFNYQFLSQLIENNSPIVCAQSNIS
AVVDSVIQALNERSLTEREGQTVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWF
A"
gene complement(<892988..>895426)
/gene="NIP1"
/locus_tag="YMR309C"
/db_xref="GeneID:855357"
mRNA complement(<892988..>895426)
/gene="NIP1"
/locus_tag="YMR309C"
/product="translation initiation factor eIF3 core subunit
c"
/transcript_id="NM_001182820.1"
/db_xref="GeneID:855357"
CDS complement(892988..895426)
/gene="NIP1"
/locus_tag="YMR309C"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:23222640]"
/experiment="EXISTENCE:direct assay:GO:0003743 translation
initiation factor activity [PMID:9671501]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:1332047]"
/experiment="EXISTENCE:direct assay:GO:0005852 eukaryotic
translation initiation factor 3 complex
[PMID:9660829|PMID:9671501]"
/experiment="EXISTENCE:direct assay:GO:0006413
translational initiation [PMID:9671501]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:19470581|PMID:26777405]"
/experiment="EXISTENCE:direct assay:GO:0031369 translation
initiation factor binding [PMID:15145951]"
/experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF
complex [PMID:11018020|PMID:15838098]"
/experiment="EXISTENCE:mutant phenotype:GO:0006413
translational initiation [PMID:9722586]"
/experiment="EXISTENCE:physical interaction:GO:0031369
translation initiation factor binding [PMID:15145951]"
/note="eIF3c subunit of the eukaryotic translation
initiation factor 3 (eIF3); involved in the assembly of
preinitiation complex and start codon selection; eIF3 is
also involved in programmed stop codon readthrough"
/codon_start=1
/product="translation initiation factor eIF3 core subunit
c"
/protein_id="NP_014040.1"
/db_xref="GeneID:855357"
/db_xref="SGD:S000004926"
/translation="MSRFFSSNYEYDVASSSSEEDLLSSSEEDLLSSSSSESELDQES
DDSFFNESESESEADVDSDDSDAKPYGPDWFKKSEFRKQGGGSNKFLKSSNYDSSDEE
SDEEDGKKVVKSAKEKLLDEMQDVYNKISQAENSDDWLTISNEFDLISRLLVRAQQQN
WGTPNIFIKVVAQVEDAVNNTQQADLKNKAVARAYNTTKQRVKKVSRENEDSMAKFRN
DPESFDKEPTADLDISANGFTISSSQGNDQAVQEDFFTRLQTIIDSRGKKTVNQQSLI
STLEELLTVAEKPYEFIMAYLTLIPSRFDASANLSYQPIDQWKSSFNDISKLLSILDQ
TIDTYQVNEFADPIDFIEDEPKEDSDGVKRILGSIFSFVERLDDEFMKSLLNIDPHSS
DYLIRLRDEQSIYNLILRTQLYFEATLKDEHDLERALTRPFVKRLDHIYYKSENLIKI
METAAWNIIPAQFKSKFTSKDQLDSADYVDNLIDGLSTILSKQNNIAVQKRAILYNIY
YTALNKDFQTAKDMLLTSQVQTNINQFDSSLQILFNRVVVQLGLSAFKLCLIEECHQI
LNDLLSSSHLREILGQQSLHRISLNSSNNASADERARQCLPYHQHINLDLIDVVFLTC
SLLIEIPRMTAFYSGIKVKRIPYSPKSIRRSLEHYDKLSFQGPPETLRDYVLFAAKSM
QKGNWRDSVKYLREIKSWALLPNMETVLNSLTERVQVESLKTYFFSFKRFYSSFSVAK
LAELFDLPENKVVEVLQSVIAELEIPAKLNDEKTIFVVEKGDEITKLEEAMVKLNKEY
KIAKERLNPPSNRR"
gene complement(<895716..>896669)
/gene="UPA2"
/locus_tag="YMR310C"
/db_xref="GeneID:855358"
mRNA complement(<895716..>896669)
/gene="UPA2"
/locus_tag="YMR310C"
/product="putative methyltransferase"
/transcript_id="NM_001182821.1"
/db_xref="GeneID:855358"
CDS complement(895716..896669)
/gene="UPA2"
/locus_tag="YMR310C"
/experiment="EXISTENCE:curator inference:GO:0032259
methylation [PMID:21858014|PMID:22650761]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/note="Putative methyltransferase; predicted to be
involved in ribosome biogenesis; green fluorescent protein
(GFP)-fusion protein localizes to the nucleus; not an
essential gene; YMR310C has a paralog, YGR283C, that arose
from the whole genome duplication"
/codon_start=1
/product="putative methyltransferase"
/protein_id="NP_014041.1"
/db_xref="GeneID:855358"
/db_xref="SGD:S000004927"
/translation="MSSTRKFKKVEKPLSQTRHYSLCIPTTLVSDCRNLSQITHKVYQ
VAKFASLFNVSEVVILEDNSQVDATKKKISTAKLILALLQYFVTPPYLRNTVFNEKFR
PYLTAASKLPRLSTLPFTRYQKQDHGRYREGLTIKMQKPTLARKKIGKVFKQTKYINI
GKSKALALQSQLVPINARVTIDTITRKIVSPQEAYGDFTGLDSQYGYYTRIASSFTDL
FMKGPLKEGYTQSVYVPLTTRDTSIPELSSLPTAETNPHILLVFSTWDTLARAFKLDQ
DQFVDCQGPQEFFDAQLPCPVSNSDVADAIPMTLTTLSTVF"
gene complement(<896914..>897603)
/gene="GLC8"
/locus_tag="YMR311C"
/db_xref="GeneID:855359"
mRNA complement(<896914..>897603)
/gene="GLC8"
/locus_tag="YMR311C"
/product="Glc8p"
/transcript_id="NM_001182822.1"
/db_xref="GeneID:855359"
CDS complement(896914..897603)
/gene="GLC8"
/locus_tag="YMR311C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0008047 enzyme
activator activity [PMID:12127071]"
/experiment="EXISTENCE:mutant phenotype:GO:0007059
chromosome segregation [PMID:7565759]"
/note="Regulatory subunit of protein phosphatase 1
(Glc7p); involved in glycogen metabolism and chromosome
segregation; proposed to regulate Glc7p activity via
conformational alteration; ortholog of the mammalian
protein phosphatase inhibitor 2; protein abundance
increases in response to DNA replication stress"
/codon_start=1
/product="Glc8p"
/protein_id="NP_014042.1"
/db_xref="GeneID:855359"
/db_xref="SGD:S000004928"
/translation="MGGILKNPLALSPEQLAQQDPETLEEFRRQVYENTQKNAKLTSH
KRNIPGLDNTKEEGEIIGTSSTFLPKDTLSLKHEQDMLAKMTPEERVQWNQRNLAENE
ITKKQFQDIHIDEPKTPYQGAVDPHGEYYRVDDDEDEDNSDKKPCQVANDDIDDLSLG
EPEFEIKENKQPDFETNDENDEDSPEARHKKFEEMRKKHYDVRAIFNKKSREALKDED
EDEDDSTTKEP"
rep_origin 897935..897985
/note="ARS1332; Autonomously Replicating Sequence"
/db_xref="SGD:S000118381"
gene <898405..>899226
/gene="ELP6"
/locus_tag="YMR312W"
/gene_synonym="HAP3; KTI4; TOT6"
/db_xref="GeneID:855360"
mRNA <898405..>899226
/gene="ELP6"
/locus_tag="YMR312W"
/gene_synonym="HAP3; KTI4; TOT6"
/product="Elongator subunit ELP6"
/transcript_id="NM_001182823.1"
/db_xref="GeneID:855360"
CDS 898405..899226
/gene="ELP6"
/locus_tag="YMR312W"
/gene_synonym="HAP3; KTI4; TOT6"
/experiment="EXISTENCE:direct assay:GO:0000049 tRNA
binding [PMID:22343726]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:22343726]"
/experiment="EXISTENCE:direct assay:GO:0033588 elongator
holoenzyme complex [PMID:11689709]"
/experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA
wobble uridine modification [PMID:18755837]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:11689709]"
/experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP
hydrolysis activity [PMID:22343726]"
/experiment="EXISTENCE:mutant phenotype:GO:0032447 protein
urmylation [PMID:14551258]"
/note="Subunit of hexameric RecA-like ATPase Elp456
Elongator subcomplex; which is required for modification
of wobble nucleosides in tRNA; required for Elongator
structural integrity"
/codon_start=1
/product="Elongator subunit ELP6"
/protein_id="NP_014043.1"
/db_xref="GeneID:855360"
/db_xref="SGD:S000004929"
/translation="MGSVQRQDLVLFSDQSVLPAHFFQDSNSHNLFFITHQSCTQPLW
MINALVETHVLGSPSSLNESSSSMLPSSTRSHAVLASFIHEQNYFTNSLNKLKIPSNN
YNVLDFLSDFIVNNIHNKPRDKILSDVLAKFSAAIQNNPTDTIVIIEQPELLLSLVSG
LTCSELNNKFITPLLRQCKVLIIVSNSDIFNIDEYDASVHSSNLQNFYKSSFIKSMIN
LNLNPLKTGFAKDVTGSLHVCRGGAPIATSNTSLHVVENEYLYLNEKESTKLFYR"
gene complement(<899379..>901307)
/gene="TGL3"
/locus_tag="YMR313C"
/db_xref="GeneID:855361"
mRNA complement(<899379..>901307)
/gene="TGL3"
/locus_tag="YMR313C"
/product="bifunctional triglyceride
lipase/lysophosphatidylethanolamine acyltransferase"
/transcript_id="NM_001182824.1"
/db_xref="GeneID:855361"
CDS complement(899379..901307)
/gene="TGL3"
/locus_tag="YMR313C"
/EC_number="3.1.1.3"
/experiment="EXISTENCE:direct assay:GO:0004806
triglyceride lipase activity [PMID:12682047]"
/experiment="EXISTENCE:direct assay:GO:0005811 lipid
droplet
[PMID:10515935|PMID:16267052|PMID:24390141|PMID:24868093]"
/experiment="EXISTENCE:direct assay:GO:0071618
lysophosphatidylethanolamine acyltransferase activity
[PMID:20016004]"
/experiment="EXISTENCE:genetic interaction:GO:0007114 cell
budding [PMID:19150427]"
/experiment="EXISTENCE:genetic interaction:GO:0019433
triglyceride catabolic process [PMID:16267052]"
/experiment="EXISTENCE:mutant phenotype:GO:0004806
triglyceride lipase activity [PMID:12682047]"
/experiment="EXISTENCE:mutant phenotype:GO:0007114 cell
budding [PMID:19150427]"
/experiment="EXISTENCE:mutant phenotype:GO:0019433
triglyceride catabolic process [PMID:16267052]"
/experiment="EXISTENCE:mutant phenotype:GO:0044255
cellular lipid metabolic process [PMID:10515935]"
/note="Bifunctional triacylglycerol lipase and LPE
acyltransferase; major lipid particle-localized
triacylglycerol (TAG) lipase; catalyzes acylation of
lysophosphatidylethanolamine (LPE), a function which is
essential for sporulation; protein level and stability of
Tgl3p are markedly reduced in the absence of lipid
droplets; required with Tgl4p for timely bud formation"
/codon_start=1
/product="bifunctional triglyceride
lipase/lysophosphatidylethanolamine acyltransferase"
/protein_id="NP_014044.1"
/db_xref="GeneID:855361"
/db_xref="SGD:S000004930"
/translation="MKETAQEYKVSAVIPTLLKNWILRVVYATLDHIPPFVWEILHVI
TDIYFFWVQKLINYVRPHSRVIYYNAIKKLDECDTYQMWCQQASVVDEITGANLWRRN
FFSRRYDFNSVIEQYSILENMLREEKYDVVKEKFSTTGPCMLRNFAGIGDKKLFTKSL
MGTKLLIEQYLTRILEGLDILNNQTLTPTSFFQRCKLSLGTTALILQGGSLFGLFHLG
VIRGLLLQDLMPNIISGSSMGACVASLFGCLSNEQLKQLLTDDNLLNIIKNDVDLLKS
CGYGNLEQHLNLGTLIQNLIHHGYSQDVYLFIRFVMKYIVKEKTFEEVYQITGKVFNI
VIHPTDKSCPNLLNYVTTPNVLIKSAIECSLGSGVISEDTSLLCKNLENEIEPFLNIN
KNKQVKFLTPENANNPSITESPYTRLTELFNVNNFIVSLARPYLAPLVVNDLKHEIKT
SKYYYYKHYPNMPPINANTVRKTQRSSSQSPIKAGTVEDLEPEPLMSPVPPSSAVNDS
AEYIIPELGIPQLNFTEMEPLAFKFKYHLERKLKNIATMEFRHRMEVLDNLGLLCSLI
KRLIIDEKTPRSATEIAVVPRMKSLSLTRIIEGQLNNIPYWIKSGERSTWPALALIKT
RCAVEFKLDDIIRARRSR"
gene <901709..>902413
/gene="PRE5"
/locus_tag="YMR314W"
/db_xref="GeneID:855362"
mRNA <901709..>902413
/gene="PRE5"
/locus_tag="YMR314W"
/product="proteasome core particle subunit alpha 6"
/transcript_id="NM_001182825.1"
/db_xref="GeneID:855362"
CDS 901709..902413
/gene="PRE5"
/locus_tag="YMR314W"
/experiment="EXISTENCE:direct assay:GO:0010499 proteasomal
ubiquitin-independent protein catabolic process
[PMID:19162040]"
/experiment="EXISTENCE:direct assay:GO:0019773 proteasome
core complex, alpha-subunit complex [PMID:9087403]"
/experiment="EXISTENCE:direct assay:GO:0034515 proteasome
storage granule [PMID:18504300]"
/experiment="EXISTENCE:direct assay:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:11545745|PMID:19029916]"
/note="Alpha 6 subunit of the 20S proteasome; protein
abundance increases in response to DNA replication stress"
/codon_start=1
/product="proteasome core particle subunit alpha 6"
/protein_id="NP_014045.1"
/db_xref="GeneID:855362"
/db_xref="SGD:S000004931"
/translation="MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHA
VLVALKRNADELSSYQKKIIKCDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRK
LAVERAGHLLCDKAQKNTQSYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTA
IGARSQGAKTYLERTLDTFIKIDGNPDELIKAGVEAISQSLRDESLTVDNLSIAIVGK
DTPFTIYDGEAVAKYI"
gene <902800..>903849
/locus_tag="YMR315W"
/db_xref="GeneID:855363"
mRNA <902800..>903849
/locus_tag="YMR315W"
/product="uncharacterized protein"
/transcript_id="NM_001182826.1"
/db_xref="GeneID:855363"
CDS 902800..903849
/locus_tag="YMR315W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0016491
oxidoreductase activity [PMID:19712762]"
/experiment="EXISTENCE:genetic interaction:GO:0006740
NADPH regeneration [PMID:19712762]"
/note="Protein with NADP(H) oxidoreductase activity;
transcription is regulated by Stb5p in response to NADPH
depletion induced by diamide; promoter contains an Stb5p
binding site and Stb5p binding is enriched at the
promoter; negative regulator of nonselective autophagy;
protein abundance increases in response to DNA replication
stress"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_014046.1"
/db_xref="GeneID:855363"
/db_xref="SGD:S000004932"
/translation="MSPLNVGIVGTGIFARDRHLPSYQEFPDKFKVIAAFNRHKAKAL
DFAKVADIPENKVYDNLDEILNDPHVDYIDALLPAQFNADIVEKAVKAGKPVILEKPI
AANLDQAKEIVKIAESTPLPVGVAENWLYLPCIKIAKEQIEKIGPVVAFTHNSTGPFV
TQNKYLTTTWRQKPEHIGGFLSDGGVHQLALVISLLGEFGSVSALTRQVRERSGADDI
VFATVQLKNKEVIGSFTYGSAFGATEKSVFLKVYGKNGTVTVDLSDKKDPVVKVKLGG
SAEDNGDEQIFKVDNDESFGVNAEFLNFHEAVSKKDKSLYLGTPRTAFHHLACVDAFL
KSSAKNGDYVKIEQP"
gene <904286..>904393
/locus_tag="YMR315W-A"
/db_xref="GeneID:1466508"
mRNA <904286..>904393
/locus_tag="YMR315W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184618.1"
/db_xref="GeneID:1466508"
CDS 904286..904393
/locus_tag="YMR315W-A"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878150.1"
/db_xref="GeneID:1466508"
/db_xref="SGD:S000028697"
/translation="MTERKLLQLLRRPFISLSLFTALRACPLRPKSLIA"
gene <904825..>905835
/gene="DIA1"
/locus_tag="YMR316W"
/db_xref="GeneID:855364"
mRNA <904825..>905835
/gene="DIA1"
/locus_tag="YMR316W"
/product="Dia1p"
/transcript_id="NM_001182829.1"
/db_xref="GeneID:855364"
CDS 904825..905835
/gene="DIA1"
/locus_tag="YMR316W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:genetic interaction:GO:0001403
invasive growth in response to glucose limitation
[PMID:11063681]"
/experiment="EXISTENCE:mutant phenotype:GO:0007124
pseudohyphal growth [PMID:11063681]"
/note="hypothetical protein; involved in invasive and
pseudohyphal growth; green fluorescent protein
(GFP)-fusion protein localizes to the cytoplasm in a
punctate pattern"
/codon_start=1
/product="Dia1p"
/protein_id="NP_014047.1"
/db_xref="GeneID:855364"
/db_xref="SGD:S000004935"
/translation="MGSISRYLLKKAADGLKDEQRLKIEMSDSKSVPECFHFNRERRM
PIAEINGEDGFFMFPSQQSLENFENTKKYSNELSPDAIGIPLFQIINCTLPFGKRGHS
NTVVGNVPYYKIFKFILRTADEPPPYTVAKIVCSNNGLILYKVPLYDIYKNVSQANVT
YSFVGTTSTEPNLLAMAHREGHRDLDTKVNNLNLRWHVTYSPVVTNDHYKLILLADYE
VNRLDEDVIRAAKNKMSIDQKDQKVQRFVAAHYTREFETSLFRWVAQEGHLILGEYST
DQGSFGLNNIPPLTEELGCQSLLIHYIEYMKRQRKKIAKEARRQNKRNVANTTNMNMN
LM"
gene complement(<905662..>905973)
/locus_tag="YMR316C-A"
/db_xref="GeneID:855365"
mRNA complement(<905662..>905973)
/locus_tag="YMR316C-A"
/product="uncharacterized protein"
/transcript_id="NM_001270757.1"
/db_xref="GeneID:855365"
CDS complement(905662..905973)
/locus_tag="YMR316C-A"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/note="hypothetical protein; SWAT-GFP and mCherry fusion
proteins localize to the endoplasmic reticulum; mRNA
identified as translated by ribosome profiling data;
overlaps the verified gene DIA1/YMR316W"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001257686.1"
/db_xref="GeneID:855365"
/db_xref="SGD:S000004933"
/translation="MTGFKVSSFFYILALSRFFNAGRERACDKLKITVTHLYWFIIRK
LLLHEVHVHVSRVCNVSFILSPCLFRNFFTLSLHVLYVMYEQALTPEFFRQWWDIIQS
K"
gene <907364..>910786
/locus_tag="YMR317W"
/db_xref="GeneID:855366"
mRNA <907364..>910786
/locus_tag="YMR317W"
/product="uncharacterized protein"
/transcript_id="NM_001182830.2"
/db_xref="GeneID:855366"
CDS 907364..910786
/locus_tag="YMR317W"
/note="hypothetical protein; has some similarity to
sialidase from Trypanosoma; YMR317W is not an essential
gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_014050.2"
/db_xref="GeneID:855366"
/db_xref="SGD:S000004936"
/translation="MGSSGSKSTTATTTSHSSTTTTSSTTSTTTPTTTSTTSTTSTKV
TTSPEIIVSSSSTLVSSVVPEFTSSSSLSSDTIASILSSESLVSIFSSLSYTSSDISS
TSVNDVESSTSGPSNSYSALSSTNAQLSSSTTETDSISSSAIQTSSPQTSSSNGGGSS
SEPLGKSSVLETTASSSDTTAVTSSTFTTLTDVSSSPKISSSGSAVTSVGTTSDASKE
VFSSSTSDVSSLLSSTSSPASSTISETLPFSSTILSITSSPVSSEAPSATSSVISSEA
SWATSSSVSSEAPLATSSVVSSEAPSSTSSVVSSEAPSSTSSSVSSEISSTTSSSVSS
EAPLATSSVVSSEAPSSTSSSVSSEISSTTSSSVSSEAPLATSSVVSSEAPSSTSSSV
SSEAPSSTSSSVSSEAPSSTSSSVSSEISSTKSSVMSSEVSSATSSLVSSEAPSAISS
LASSRLFSSKNTSVTSTLVATEASSVTSSLRPSSETLASNSIIESSLSTGYNSTVSTT
TSAASSTLGSKVSSSNSRMATSKTSSTSSDLSKSSVIFGNSSTVTTSPSASISLTASP
LPSVWSDITSSEASSISSNLASSSAPSDNNSTIASASLIVTKTKNSVVSSIVSSITSS
ETTNESNLATSSTSLLSNKATARSLSTSNATSASNVPTGTFSSMSSHTSVITPGFSTS
SASLAINSTVVSSSLAGYSFSTPESSPTTSTLVTSEAPSTVSSMTTSAPFINNSTSAR
PSPSTASFITESTSSISSVPLASGDVTSSLAAHNLTTFSAPSTSSAQLVSKSTTSSSI
LVTPRIDRSGNSSTASRIATSLPNKTTFVSSLSSTSAHARNIFNSTVLATAKQIETLT
STVNCSNPTPNYNITKTVIVSRETTAIGTVTSCSGGCTKNRKSTTLITITDIDASTVT
TCPEKEVTSTTSGDEAEHTTSTKISNFETSTFSESFKDMKTSQETKKAKPGSETVRSS
SSFVEKTSPTTKASPSTSPSESKAAGNTSVATNASPSTSPSESQGTGSTSVEGAKSKS
TKNSEGVSTTKAKNTSTVAKSSTESPIGRGETTLETIIVSSQKSLLTSQLSSSTEKVN
RSTTKPTAAIHGTSSSAKQSTTYTVSTAKENTGASLNINMKAFVIGAIALVA"
gene complement(<911061..>912143)
/gene="ADH6"
/locus_tag="YMR318C"
/gene_synonym="ADHVI"
/db_xref="GeneID:855368"
mRNA complement(<911061..>912143)
/gene="ADH6"
/locus_tag="YMR318C"
/gene_synonym="ADHVI"
/product="NADP-dependent alcohol dehydrogenase"
/transcript_id="NM_001182831.3"
/db_xref="GeneID:855368"
CDS complement(911061..912143)
/gene="ADH6"
/locus_tag="YMR318C"
/gene_synonym="ADHVI"
/EC_number="1.1.1.2"
/experiment="EXISTENCE:direct assay:GO:0006066 alcohol
metabolic process [PMID:11742541]"
/experiment="EXISTENCE:direct assay:GO:0006081 cellular
aldehyde metabolic process [PMID:11742541]"
/experiment="EXISTENCE:direct assay:GO:0008106 alcohol
dehydrogenase (NADP+) activity [PMID:11742541]"
/experiment="EXISTENCE:mutant phenotype:GO:0033833
hydroxymethylfurfural reductase (NADH) activity
[PMID:16652391]"
/experiment="EXISTENCE:mutant phenotype:GO:0033845
hydroxymethylfurfural reductase (NADPH) activity
[PMID:16652391]"
/experiment="EXISTENCE:mutant phenotype:GO:0033859
furaldehyde metabolic process [PMID:16652391]"
/note="NADPH-dependent medium chain alcohol dehydrogenase;
has broad substrate specificity; member of the cinnamyl
family of alcohol dehydrogenases; may be involved in fusel
alcohol synthesis or in aldehyde tolerance; protein
abundance increases in response to DNA replication stress"
/codon_start=1
/product="NADP-dependent alcohol dehydrogenase"
/protein_id="NP_014051.3"
/db_xref="GeneID:855368"
/db_xref="SGD:S000004937"
/translation="MSYPEKFEGIAIQSHEDWKNPKKTKYDPKPFYDHDIDIKIEACG
VCGSDIHCAAGHWGNMKMPLVVGHEIVGKVVKLGPKSNSGLKVGQRVGVGAQVFSCLE
CDRCKNDNEPYCTKFVTTYSQPYEDGYVSQGGYANYVRVHEHFVVPIPENIPSHLAAP
LLCGGLTVYSPLVRNGCGPGKKVGIVGLGGIGSMGTLISKAMGAETYVISRSSRKRED
AMKMGADHYIATLEEGDWGEKYFDTFDLIVVCASSLTDIDFNIMPKAMKVGGRIVSIS
IPEQHEMLSLKPYGLKAVSISYSALGSIKELNQLLKLVSEKDIKIWVETLPVGEAGVH
EAFERMEKGDVRYRFTLVGYDKEFSD"
gene complement(<912880..>914538)
/gene="FET4"
/locus_tag="YMR319C"
/db_xref="GeneID:855369"
mRNA complement(<912880..>914538)
/gene="FET4"
/locus_tag="YMR319C"
/product="Fet4p"
/transcript_id="NM_001182832.1"
/db_xref="GeneID:855369"
CDS complement(912880..914538)
/gene="FET4"
/locus_tag="YMR319C"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005375 copper ion
transmembrane transporter activity [PMID:11023834]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:12469340|PMID:9115232]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0006829 zinc
ion transport [PMID:12095998]"
/experiment="EXISTENCE:mutant phenotype:GO:0005375 copper
ion transmembrane transporter activity [PMID:11023834]"
/experiment="EXISTENCE:mutant phenotype:GO:0005381 iron
ion transmembrane transporter activity [PMID:7929320]"
/experiment="EXISTENCE:mutant phenotype:GO:0006829 zinc
ion transport [PMID:12095998]"
/experiment="EXISTENCE:mutant phenotype:GO:0015677 copper
ion import [PMID:11023834]"
/experiment="EXISTENCE:mutant phenotype:GO:0015680 protein
maturation by copper ion transfer [PMID:11523804]"
/experiment="EXISTENCE:mutant phenotype:GO:0034755 iron
ion transmembrane transport [PMID:7929320]"
/note="Low-affinity Fe(II) transporter of the plasma
membrane"
/codon_start=1
/product="Fet4p"
/protein_id="NP_014052.1"
/db_xref="GeneID:855369"
/db_xref="SGD:S000004938"
/translation="MGKIAEFLGNPGARPDVHHRAPTVDCKQYEEFGDSNDYKNDDVV
RVVSHSDESTDDELCNVNLTETGAIFTSKGFTGLSKGFTDKTLDFLVRVAGSQAVFFI
VWIILIIWVVIGIVYNAPFNWQVVMQDGQSIQSYVWDTLLMRQQLMSTHEQILICGRL
KSRLASFKNYLTRSTPEEEKADCTVEANEVSSVENHIDPSAINGELPVENWYDRLSNV
ASRYMGSIAAMVIFWIGIFVWIGCGAIPKDAGNTPPYTGETTGSNPRLKKFSDAWQMY
INTAVAVSLLICTTFLQNIRARHDYFTGRFLVDIFDMDEKIDYRIRKHFNDFETPHPV
VTIESKKRSTGRKMIDWYADIIGTGIGVLIGVAVFATWIGIGSPMKWDDNWWLIIGTY
TGLIGFLDGFVLREVYFRIVQHEEKNYSDVAKEDLELFQELGIECPEEFSGKAPEINT
IGYRTSQYINRICSTPWSVLVSVIIIIGLICIASGLRWSTTGQLIANTPTMIIEEFFL
LVLLQAHNWADRQRRVEVTALYARRRILLSYVEKRFPEVMMLEK"
gene <916746..>917051
/locus_tag="YMR320W"
/db_xref="GeneID:855370"
mRNA <916746..>917051
/locus_tag="YMR320W"
/product="uncharacterized protein"
/transcript_id="NM_001348871.1"
/db_xref="GeneID:855370"
CDS 916746..917051
/locus_tag="YMR320W"
/note="hypothetical protein; conserved among S. cerevisiae
strains; YMR320W is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335810.1"
/db_xref="GeneID:855370"
/db_xref="SGD:S000004939"
/translation="MRRFGKPCIVSHEISARPHILQPCNYKMVLSCKVKKPIELLHLQ
ELILYTFMKICLHVNLIQQNINKLSYISRKYPRAPAFISCDNRATEPTKKGFLVCRM"
gene complement(<917579..>917896)
/locus_tag="YMR321C"
/db_xref="GeneID:855371"
mRNA complement(<917579..>917896)
/locus_tag="YMR321C"
/product="uncharacterized protein"
/transcript_id="NM_001182834.3"
/db_xref="GeneID:855371"
CDS complement(917579..917896)
/locus_tag="YMR321C"
/note="hypothetical protein; proposed to be a
palmitoylated membrane protein; YMR321C has a paralog,
SAM4, that arose from a single-locus duplication"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_014054.3"
/db_xref="GeneID:855371"
/db_xref="SGD:S000004940"
/translation="MMDLGDKINPNLSFLGINCVSFNQSPDILESLHQALPNMALLAY
PNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVK
KYT"
rep_origin 917896..918366
/note="ARS1333; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130193"
gene complement(<918366..>919079)
/gene="SNO4"
/locus_tag="YMR322C"
/gene_synonym="HSP34"
/db_xref="GeneID:855372"
mRNA complement(<918366..>919079)
/gene="SNO4"
/locus_tag="YMR322C"
/gene_synonym="HSP34"
/product="glutathione-independent methylglyoxalase family
protein"
/transcript_id="NM_001182835.1"
/db_xref="GeneID:855372"
CDS complement(918366..919079)
/gene="SNO4"
/locus_tag="YMR322C"
/gene_synonym="HSP34"
/EC_number="4.2.1.130"
/experiment="EXISTENCE:direct assay:GO:0019172 glyoxalase
III activity [PMID:26370081]"
/experiment="EXISTENCE:mutant phenotype:GO:0019172
glyoxalase III activity [PMID:26370081]"
/experiment="EXISTENCE:mutant phenotype:GO:0031669
cellular response to nutrient levels [PMID:24706893]"
/note="Possible chaperone and cysteine protease; required
for transcriptional reprogramming during the diauxic shift
and for survival in stationary phase; similar to bacterial
Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI
superfamily member; predicted involvement in pyridoxine
metabolism; induced by mild heat stress and copper
deprivation"
/codon_start=1
/product="glutathione-independent methylglyoxalase family
protein"
/protein_id="NP_014055.1"
/db_xref="GeneID:855372"
/db_xref="SGD:S000004941"
/translation="MTPKRALISLTSYHGPFYKDGAKTGVFVVEILRSFDTFEKHGFE
VDFVSETGGFGWDEHYLPKSFIGGEDKMNFETKNSAFNKALARIKTANEVNASDYKIF
FASAGHGALFDYPKAKNLQDIASKIYANGGVIAAICHGPLLFDGLIDIKTTRPLIEGK
AITGFPLEGEIALGVDDILRSRKLTTVERVANKNRAKYLAPIHPWDDYSITDGKLVTG
VNANSSYSTTIRAINALYS"
gene <920088..>921401
/gene="ERR3"
/locus_tag="YMR323W"
/db_xref="GeneID:855373"
mRNA <920088..>921401
/gene="ERR3"
/locus_tag="YMR323W"
/product="phosphopyruvate hydratase ERR3"
/transcript_id="NM_001182836.3"
/db_xref="GeneID:855373"
CDS 920088..921401
/gene="ERR3"
/locus_tag="YMR323W"
/EC_number="4.2.1.11"
/experiment="EXISTENCE:direct assay:GO:0004634
phosphopyruvate hydratase activity [PMID:23359425]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:genetic interaction:GO:0004634
phosphopyruvate hydratase activity [PMID:23359425]"
/note="Enolase, a phosphopyruvate hydratase; catalyzes the
conversion of 2-phosphoglycerate to phosphoenolpyruvate;
complements the growth defect of an ENO1 ENO2 double
mutant in glucose"
/codon_start=1
/product="phosphopyruvate hydratase ERR3"
/protein_id="NP_014056.3"
/db_xref="GeneID:855373"
/db_xref="SGD:S000004942"
/translation="MSITKVHARTVYDSRGNPTVEVEITTENGLFRAIVPSGASTGIH
EAVELRDGNKSEWMGKGVTKAVSNVNSIIGPALIKSDLCVTNQKGIDELMISLDGTSN
KSRLGANAILGVSLCVARAAAAQKGITLYKYIAELADARQDPFVIPVPFFNVLNGGAH
AGGSLAMQEFKIAPVGAQSFAEAMRMGSEVYHHLKILAKEQYGPSAGNVGDEGGVAPD
IDTAEDALDMIVKAINICGYEGRVKVGIDSAPSVFYKDGKYDLNFKEPNSDPSHWLSP
AQLAEYYHSLLKKYPIISLEDPYAEDDWSSWSAFLKTVNVQIIADDLTCTNKTRIARA
IEEKCANTLLLKLNQIGTLTESIEAANQAFDAGWGVMISHRSGETEDPFIADLVVGLR
CGQIKSGALSRSERLAKYNELLRIEEELGDDCIYAGHRFHDGNKL"
gene <922641..>923015
/gene="PAU19"
/locus_tag="YMR325W"
/db_xref="GeneID:855375"
mRNA <922641..>923015
/gene="PAU19"
/locus_tag="YMR325W"
/product="seripauperin PAU19"
/transcript_id="NM_001182838.1"
/db_xref="GeneID:855375"
CDS 922641..923015
/gene="PAU19"
/locus_tag="YMR325W"
/note="hypothetical protein; member of the seripauperin
multigene family encoded mainly in subtelomeric regions"
/codon_start=1
/product="seripauperin PAU19"
/protein_id="NP_014058.1"
/db_xref="GeneID:855375"
/db_xref="SGD:S000004944"
/translation="MVKLTSIAAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVS
DIRAHLAQYYLFQAAHPTETYPVEIAEAVFNYGDFTTMLTGIPAEQVTRVITGVPWYS
TRLRPAISSALSKDGIYTAIPK"
rep_origin 923015..923494
/note="ARS1335; Putative replication origin; identified in
multiple array studies, not yet confirmed by plasmid-based
assay"
/db_xref="SGD:S000130194"
telomere 923541..924431
/note="TEL13R; Telomeric region on the right arm of
Chromosome XIII; composed of an X element core sequence, X
element combinatorial repeats, and a terminal stretch of
telomeric repeats"
/db_xref="SGD:S000028989"
CONTIG join(BK006946.2:1..924431)
//