LOCUS NC_018871 28494 bp RNA linear VRL 31-DEC-2021
DEFINITION Rousettus bat coronavirus HKU10, complete genome.
ACCESSION NC_018871
VERSION NC_018871.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Rousettus bat coronavirus HKU10
ORGANISM Rousettus bat coronavirus HKU10
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
Alphacoronavirus; Decacovirus; Bat coronavirus HKU10.
REFERENCE 1 (bases 1 to 28494)
AUTHORS Lau,S.K., Li,K.S., Tsang,A.K., Shek,C.T., Wang,M., Choi,G.K.,
Guo,R., Wong,B.H., Poon,R.W., Lam,C.S., Wang,S.Y., Fan,R.Y.,
Chan,K.H., Zheng,B.J., Woo,P.C. and Yuen,K.Y.
TITLE Recent Transmission of a Novel Alphacoronavirus, Bat Coronavirus
HKU10, from Leschenault's Rousettes to Pomona Leaf-Nosed Bats:
First Evidence of Interspecies Transmission of Coronavirus between
Bats of Different Suborders
JOURNAL J. Virol. 86 (21), 11906-11918 (2012)
PUBMED 22933277
REFERENCE 2 (bases 1 to 28494)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-NOV-2012) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 28494)
AUTHORS Lau,S.K.P., Woo,P.C.Y., Li,K.S.M., Tsang,A.K.L., Shek,C.-T.,
Wang,M., Choi,G.K.Y., Guo,R., Wong,B.H.L., Poon,R.W.S., Lam,C.S.F.,
Wang,S.Y.H., Fan,R.Y.Y., Chan,K.-H., Zheng,B.-J. and Yuen,K.-Y.
TITLE Direct Submission
JOURNAL Submitted (26-APR-2012) Department of Microbiology, The University
of Hong Kong, University Pathology Building, Queen Mary Hospital,
Hong Kong, China
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence is identical to JQ989270.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..28494
/organism="Rousettus bat coronavirus HKU10"
/mol_type="genomic RNA"
/isolate="183A"
/host="bat"
/db_xref="taxon:1241933"
/country="China"
/collection_date="Oct-2005"
5'UTR 1..302
gene 303..20644
/locus_tag="D425_gp1"
/note="ORF1ab"
/db_xref="GeneID:13842724"
CDS join(303..12617,12617..20644)
/locus_tag="D425_gp1"
/ribosomal_slippage
/note="ORF1ab polyprotein is cleaved to yield the
RNA-dependent RNA polymerase and other nonstructural
proteins; polyprotein pp1ab"
/codon_start=1
/product="ORF1ab polyprotein"
/protein_id="YP_006908641.2"
/db_xref="GeneID:13842724"
/translation="MASNQLTLAFANDSEISAYGFDTVEHAVAQYSAAAANGFAQCRF
VITGLQDLVVGVNDEEFVLVVTGLHQLTARIGKFGDQPQNLRGWLLFSNSNYFLGELD
LIFGNRGGTTVFVDNFLCGANGLPACSEQEWEFKDYFGELDEVIINGTTFVKAWNVDR
TPGPYSTQNLLSINSISWCGEIPHSLADGSIRRVAKVVKKSKSVLLGKQFQQLYDSVG
SPFVTNGKNLTDVLVKPIYCHALVKCQCGKTSWTVGDWSCYKSMCCGFNCKPLAIVNG
EVVPGDVLVTSDKVSASGTKYYNGMVLKFVDKIDNACLWRITQVQSCMDVVASGNYKG
DEFIYHTDDICSPTNMSKISHAFKLCYFTGSYTDEVKSALLHGEFDVCTNICDVSDHS
IHKPWFVREMEELLGGAWDNFVKAVKSLSVLNSQLFDLMSGLAKATIRVVNGCIEFCA
NIPTCFNDAFECLKSFVETLFDLTVNTVTFAGQSFKAVGDYVLLNNAIVKFVSVKVKG
LHQDGIKSTMYATTVVGKTAKVKSRRIETCNANLSVVPDQALVKDGVTKIIGGRSFFC
SGGCYRLMSDVDTVIMSPVYQAVAPTEVVFNCVKPAGFVDPVCSTLPELVSDVTKQLL
PLNKPYRFYDVKVKDGMCIVTQETTFRAPSYIANSALFVQLCEECVDVQGFDDFYVKA
HEATSLSQFEPMFPAFQQFVKSVDCPQILKDIDGGGIWKTFIQTVSDAVEFVKSIKVD
FGLDGIIITATKRFKKFAGILLNLYREFIASVTSVVKIGGKSFTYYLFEKPKMAISGI
LHNVRVLKAKDCTIAAEDILVEMTVFDSFEIPIQPSRVEVQQVEFEEAEFVQPQAGGV
LAVVNKHVFYNKGDYYYPANETHAVPVCYKRGSGTNGTVVKFSEAVQVKEIEPVHRVK
LEYEFEDETIVEICKKVIGKRYKFTGTEWEELCSYIHSVMKTVSDHIEVPEYFVYDEE
GGNDFTKVVMVSQYSIADEQPENVGQTDVLKEEQTVEATSKSQVVQPLKQQEPVKPQK
SQIEEVNEALSFMLEPVQQKPKVNPFNFEFYDYKGIRVLKQKDNNCWVSSTLVQLQLL
DCYSDPAFDLFKAGSVAPIVQKCYELTRNIVGSAGDVSFALEQLLKDLHTMFITFDVV
CGCNNGERRQSELSGCVFRFLPTSEPFAYGGCPSCDKPLMHTITSMQGTGVFCQDPKA
VDVTTLLVQPMCASAFIGNWFNNSLGHYKTNVYDKGFCVDGNGSWPITLNTLNTICYK
DVNYVRPLPVVSDQPIVEEKTKQDELKPFATYRNVEFYKGEISDLVQLKHDFVVNAAN
ENLSHGGGVAAAINNLTKGLLQTLSDHYVKKNGKIKVGQGVMLHCGKENVLNVVGPRK
GKHSPQLLEKAYKFVLKQKGTPLTPLLSVGIFKVPILESVTALKNVVGDRHVKCFCYS
VAEVSEIQKCLDNDVVEPKMEVPQIESETVISVSQNTEQQAFSHVDRRELKPCRVEGK
FSFYDCPIADIAITEPERVVFFTDVKLSFCEAAKALDKHYEGALTSCVQAYLAETPLI
PAGNLLTLKCEGAIPVSFAVLPDTDAANYNKDVKRTLTKVSKLKGKIFCTIPTVDVMK
QMLKCCNTSFIVTDATKTRLSECFESAVVEVKVTHDGRDVHTVKVKTDVVLDEQVGVC
SLNNCDLTGVKPDDAIVDVVSVAPEVDWISYYGFPRADLYHTLDHKQYAYENSDVEGK
RVLKFSDNNCWVNTICLQLQFAKAIFKTEGLQAMWDEFLTGRVERFVHWLYWYQNIEK
GQPGDVEYLLGKISRYLVNSGTVTISKDSVCCNSKRTLTTPVVEASILKSGFDDGVCK
HGNACVSRISAVRGTVIVIQTGKPKVYPRAALIDGDTYTTYSGSVEDGHYTVFETKNS
RVYDGDTVSTGNDLSTHAVSSVVVANKLFDDPIEVVEREASSIVNTLDTSAEKFFSFG
DIVSRNCVTFLVWLFSMFSLAFKAFRTRDVKVIAQVPQRTGLILSRSLKYNVKATNKF
LQSRTKWVVLFSKMLLVLSTLYALWFLLLRFGPLHDTVCTSYVEGYSKSNFDKNAFCE
NLACKTCLYGYEELSDFPHTVTTWTHLGDPLFKTLLPLIYIAFLLIFGGVVVRGFMLY
FVAQYVNQFGVVLGFQDSVWALQLVPFSIFGDEIVVLFLVIKFMLFLKHVFFGCEKPS
CVACSKSARLTRIPMQTIVNGSNRSFYVVANGGKKFCEKHKFFCVNCDSYGQGNTFIN
DVVAAEVSNVVKTNVIATGPAVIDITKVEFHNGFYYLYGDDGKTFWRYNFDITEGKYS
CKEVLKNSNVLADFIVYNNVGSNLAQVKNACVYFSQLLCKPIKLVDATLLATLNVDFN
GALHAAFVEVLNESFGKDLKSCSTMADCKTALDIDADDEEFVNGVSNAHRYNTLLSDL
SYNNFVTSYAKPEEKLSTHDLAACMRGGAKVVNHNILVKENVPIVWYAKDFNMLSEEG
RRYVVKTAKLKGVNFLLTFNDNRMQTQIPVVSVTTKCGSGIRRCYNYIWWICAFILCV
FLATGFVDYTSMVVSASDYDFRYIEGGKLKVFETPLKCVHNTFANFDNWYNSKFGFTP
SKDKRCPIVVGVSNEARTIPGVPSGVFLFGKTLVFALQIVFGGSHTCYDMTGPAPLDR
CIFDSACTTLNGLGGERVYCYKNGLVEGSLLYTDLQPNSYYSLPVGGYVRLPEVITSG
LGFRTVRTQQTTYCRMGECVDSKAGICFGANRFLVYSAESGTDFVCGTGLLSLLLNVF
NMFSSSFSVLAMSGQIVFNCVLTCVIIMACLLVTKLKRMFGDLSLGVCTVVCVAIVNN
LSYIITQNAVMMVVYAILYFLSTRTFKYGWIWHVGYCIAYLSMAPWWLLFWYMCSALI
GLVPSLLKLKVTSQLFDGDKFVGNFETAATGTFVLDMHSYQRIVNSIAPEKIKQHAAS
YNKYKYYSGAASEADYRLACYAHLAKAVLDYGTNHQDTLYTPPTISYNSTLQSGLRKM
AQPSGVVEKCVVRVCYGNMALNGLWLGDVVICPRHVIASNTNALIDYEHEISVMRLHN
FSVSVGNVFLGVVSATMKGANLHIKVNQTNVNTPEHSFKTIKQGESFNILACYDGMPS
GVYGVTMRNNYTIRGSFITGACGSPGYNVTNGKVEFCYLHQLELGSGCHVGSNLEGVM
YGCYEDQPTLQIEGVNHLVTPNVIAFLYGALLNGITWWLNSDKVSVESFNEWALNNGF
TTCGNLDCFNMLSAKTGVDVQRLLAAVQRLHNSFGGKNILGYTTLTDEFTVGEVIKQM
YGVTLQSNKVVGAFCNLAIVGLFVTMFWSELLQYTAFFWVSPGFVTPVFFALLLVSFI
LMCFLKHKVLFLYTFLIPSVIIMASYNFMWDWSVAAELARIFDYHVSIVSFDIQGLLN
VAVCLFVTLLHTMRFFKTNTSISTYVLSLAFTVYGFVVGSDVLSIVMTLLFNLTSSWY
VGAIVYKLAYYLQYYTSFAQILGSIKAIMLCYMGLGYLCCVYYGFLYWINRFCKLSLG
VYDFKVSANEFKFMVANGLQAPRGVFDSLALSIKLMGIGGEKTIKVSSVQSKLTDIKC
TNVVLLGCLSSMNIAANTKEWSYCVDLHNKINLCNDPEAAQEMLLALLAFFLSKHKDF
GFDDLLDSYFADNSILQSVASTFVNMPSFIAYENARQAYEDAIANDSAPQLVKQLKTA
MNIAKSEFDREVSVQKKISRMAEQAAAQMYKEARAVNRKSKVIGAMHSLLMGMLRKLD
MSNVDTILNLAKDGVVPLSIIPAACSTKLNVVSADLDSYYKICRDGCVHYAGVIWNVI
DIRDNDGKIVHAKEIAPENVENIAWPIFLNCERIVKLQNNEIMPGKLKQRPVKAEGDG
ISADGMALFNNESGKTFMYAFIADKPDLKFVKWEFDNGCSVIELEPPCRFAVQTPTGT
TIKYLYFVRNLNTLRRGAVLGFIGATVRLQAGKQTELAVNSPLLTMCAFAVDPAKTYL
DAVKRGAKPVGNCIKMLANGSGTGQAVTTGVEANTNQDSYGGASVCLYCRAHVEHPSM
DGYCKLKGRYVQVPMGTIDPIRFVLENEACKVCQCWLNNGCACDRVSTSMQAFDNGYL
NRARGSSAAQLEPCNGTDTDHCVRAFDIYNKDVACLGKFLKTNCVRFRNKLHKDAYFV
IKRCPKSVMEHEQSIYDILKDSGAIATHDFFVWKDGRMIYGNISRQDLTKYTMMDLVY
ALRNFDEKNCETLKEILVITGACDQSYFDNKFWFDPVENEDLHRVYAILGKIVANAML
KCVRLGDAMVKHGIVGVITLDNQDLNGNFYDFGDFAKTLPGMGVPLCTSYYSYMMPVM
GMTNCLAGECFIKSDIFGSDFKSFDLLHYDFTDHKQALFEKYFKHWDQEYHPNCVDCH
DELCIVHCANFNTLFSTTIPITAYGPLCRKVFVDGVPLVATAGYHFKQLGIVWNKDLN
THSTRLTINELLQFVTDPSLLVASSPALVDQRTVCFSVAALGTGMTKQTMQPGHFNKE
FYDFLRKQGFFEEGSELTLKHFFFAQKGDAAIKDFDYYRYNKPTMLDVCQARVAYKLV
SRYFDIYDGGCITAKDVVVTNLNKSAGYPLNKFGKAGLYYESLTYEEQDALYAVTKRN
VLPTMTQLNLKYAISGKERARTVGGVSLLSTMTTRQYHQKHLKSIVNTRNASVVIGTT
KFYGGWDNMLNTLINGVENPCLMGWDYPKCDRALPNMIRMISAMILGSKHTTCCTTDE
RYYRLCNELAQVLTEVVYSNGGFYFKPGGTTSGDASTAYANSVFNIFQAVSSNINRLL
TIDSNVCNNVSVKTLQRELYDNCYRSSSVDEQFIDKYYCYLRKHFSMMILSDDGVVCY
NKDYADLGYVADISAFKATLYYQNNVFMSTSKCWVEPDITKGPHEFCSQHTMQIVDEN
GKYYLPYPDPSRILSAGVFVDDVVKTDAVILLERYVSLAIDAYPLSKHPNPEYRKVFY
VLLDWVKHLHNTLNQGVLESFSVTLLEDTSSKFWDESFYANMYEKSAILQSAGLCVVC
GSQTVLRCGDCLRRPMLCTKCAYDHVIATPHKFILAITPYVCSYSGCNVNDVTQLYLG
GLSYYCAEHKPRLSFPLCSAGNVFGLYKASATGSPDVEIFNTLATSDWTDVRDYKIAN
EAKDSLRLFAAETIKAKEESVKSSYACATLKEVIGPKELLLSWECGKVKPPLNRNSVF
TCFHITKDSKFQVGEFVFEKVDYGSDAVSYKSTSTSKLSPGMVFVLTSHNVQPLRAPT
IANQERYSSIHKLYPSFNIADAYSTLVPYYQMIGKQRITTIQGPPGSGKSHCVIGLGL
YYPGARIVFTACSHAAVDSLCVKASTAYVNDRCSRIIPARARVDCFSGFKSNNNSAQY
LFSTVNALPECNADIVVVDEVSMCTNYDLSVINQRLSYKHIVYVGDPQQLPAPRTMIL
RGVLEPKDYNVVTQRMCAVGPDVFLHKCYRCPAEIVKTVSEMVYDNKFVPVHPESKQC
FKLFCKGNVHVDNGSSINRKQLDVVKLFLAKNPSWSKAVFISPYNSQNYVASRALGLQ
IQTVDSSQGSEYDYVIFTQTSDTQHACNVNRFNVAITRAKKGILCIMCDKELFDALKF
FEIKLTDLQAGEGCGLFKDCSRKPDLLPPSHATTFMSLSDNFKTSGDLAVQVGVNGVC
KYEHVISFMGFRFDTNIPGYHSLFCTRDFAMRHVRGWLGMDVEGAHVVGDNIGTNVPL
QVGFSNGVDFVVQPEGCVVNEFGTNIQPVRARAPPGEQFAHLIPLMRRGQPWVVVRKR
IVQMCCDYLSGLSDVLVFVLWAGGLELTTMRYFVKVGQVKHCHCSKESTCYNSTTHEY
YCFKHALGCDYLYNPFVIDIQQWGYTGSLSLNHHEVCNVHRNEHVASGDAIMTRCLAI
HDCFVKSLDWSITYPFIANEREINSGGRVVQRMLMKTAIKLYNPKAIHDIGNPKGIRC
AVTDAKWFCYDRQPLNSNVKLFEYDYITHGQLDGLCLFWNCNVDMYPEFSIVCRFDTR
CRSSLNLEGTNGGSLYVNKHAFHTPAFDKRAFAKLKPAPFFFYDDGPCDRIQEEINYV
PLRAANCITRCNIGGAVCSTHAKQYYDYVNAYNSYTQAGFTLWVPNTFDLFNLWQTFA
DTKLQSLENIAYNVIKKGSFVGESGELPVAIVNDKVFVREGTVDNLVFVNKTSLPANV
AFELFAKRKVGLTPPLSVLRNLGVVSTYKFVLWDYEAERPFTSFTKSTCSYTDFDEDV
TTCFDNAIAGSFERFTLTRNAVLISNVAIKKLVGMKIAYGLLNGVPVSVCENKPVTWY
IYVRKDGQFVDQYDGYYTQGRNIAEFLPRSDMEKDFLEMDMGMFINKYGLEDYAFEHV
VYGDVSKTTLGGLHLLISQVRLQKMGVLKIDEFTSSNDGTLKSCTVTYANNPSSKMVC
TYMDLLLDDFVTILKNLDLDVVSKVQEVIIDCKVWRWMLWCKGHKVQTFYPQLQSAEW
KCGYSMPSIYKIQRMCLEPCNLYNYGASIKLPDGIMFNVVKYTQLCQYLNSTTMCVPY
NMRVLHLGAGSDKGVAPGTAVLRRWLPSDAIIVDNDVEDYVSDADYSITGDCSTVYLE
DKFDLVISDMYDGKTKHCDGENVSKEGFFVYFNGVINEKLALGASVAIKVTEYSWNKK
LYELVQRFEFWTLFCTSVNTSSSEAFLVGINYLGTFSDKPVIDGNVVHANYIFWRNST
IMSMSYNSVLDLAKFNCKHRATAVIQLKDSDINDMVLGLIKRGKILVRMNGTYMGFSN
HLVSTKQR"
misc_feature 309..632
/locus_tag="D425_gp1"
/note="non-structural protein 1 from porcine epidemic
diarrhea virus and similar alphacoronaviruses; Region:
PEDV-like_alphaCoV_Nsp1; cd21875"
/db_xref="CDD:409337"
misc_feature order(501..515,534..557,609..632)
/locus_tag="D425_gp1"
/note="critical sequence motifs; other site"
/db_xref="CDD:409337"
misc_feature 633..2453
/locus_tag="D425_gp1"
/note="alphacoronavirus non-structural protein 2 (Nsp2),
similar to HCoV-229E Nsp2 and related proteins; Region:
alphaCoV_Nsp2_HCoV-229E-like; cd21514"
/db_xref="CDD:394865"
misc_feature 2502..2972
/locus_tag="D425_gp1"
/note="Coronavirus replicase NSP2, C-terminal; Region:
CoV_NSP2_C; pfam19212"
/db_xref="CDD:437049"
misc_feature <3462..4070
/locus_tag="D425_gp1"
/note="Coronavirus (CoV) papain-like protease (PLPro);
Region: CoV_PLPro; cl40457"
/db_xref="CDD:424088"
misc_feature order(3522..3533,3666..3674,3678..3683,3780..3782,
3828..3833,3837..3839,3909..3911,3960..3962,3990..3998)
/locus_tag="D425_gp1"
/note="ubiquitin binding site [polypeptide binding]; other
site"
/db_xref="CDD:409647"
misc_feature order(3666..3674,3906..3911,3960..3962,3978..3980,
3996..3998)
/locus_tag="D425_gp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409647"
misc_feature 4236..4610
/locus_tag="D425_gp1"
/note="X-domain (or Mac1 domain) of viral non-structural
protein 3 and related macrodomains; Region:
Macro_X_Nsp3-like; cd21557"
/db_xref="CDD:438957"
misc_feature order(4254..4262,4272..4292,4509..4514,4518..4532,
4605..4607)
/locus_tag="D425_gp1"
/note="ADP-ribose binding site [chemical binding]; other
site"
/db_xref="CDD:438957"
misc_feature 5214..6074
/locus_tag="D425_gp1"
/note="alphacoronavirus papain-like protease; Region:
alphaCoV_PLPro; cd21731"
/db_xref="CDD:409648"
misc_feature order(5502..5513,5661..5669,5673..5678,5685..5687,
5769..5771,5817..5822,5826..5828,5901..5903,5949..5951,
5970..5978,6060..6062)
/locus_tag="D425_gp1"
/note="ubiquitin binding site [polypeptide binding]; other
site"
/db_xref="CDD:409648"
misc_feature order(5661..5669,5898..5903,5949..5951,5958..5960,
5976..5978,6060..6062)
/locus_tag="D425_gp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409648"
misc_feature 6348..7850
/locus_tag="D425_gp1"
/note="C-terminus of alphacoronavirus non-structural
protein 3, including transmembrane and Y domains; Region:
TM_Y_alphaCoV_Nsp3_C; cd21712"
/db_xref="CDD:409660"
misc_feature 6348..6413
/locus_tag="D425_gp1"
/note="TM1 [structural motif]; Region: TM1"
/db_xref="CDD:409660"
misc_feature 6612..6680
/locus_tag="D425_gp1"
/note="TM2 [structural motif]; Region: TM2"
/db_xref="CDD:409660"
misc_feature 7881..8981
/locus_tag="D425_gp1"
/note="coronavirus non-structural protein 4 (Nsp4)
transmembrane domain; Region: cv_Nsp4_TM; cd21473"
/db_xref="CDD:394836"
misc_feature 7881..7949
/locus_tag="D425_gp1"
/note="putative TM helix 1 [structural motif]; Region:
putative TM helix 1"
/db_xref="CDD:394836"
misc_feature 8646..8711
/locus_tag="D425_gp1"
/note="putative TM helix 2 [structural motif]; Region:
putative TM helix 2"
/db_xref="CDD:394836"
misc_feature 8751..8816
/locus_tag="D425_gp1"
/note="putative TM helix 3 [structural motif]; Region:
putative TM helix 3"
/db_xref="CDD:394836"
misc_feature 8889..8957
/locus_tag="D425_gp1"
/note="putative TM helix 4 [structural motif]; Region:
putative TM helix 4"
/db_xref="CDD:394836"
misc_feature 9012..9287
/locus_tag="D425_gp1"
/note="Coronavirus nonstructural protein 4 C-terminus;
Region: Corona_NSP4_C; pfam16348"
/db_xref="CDD:406690"
misc_feature 9297..10184
/locus_tag="D425_gp1"
/note="alphacoronavirus non-structural protein 5, also
called Main protease (Mpro); Region: alphaCoV_Nsp5_Mpro;
cd21665"
/db_xref="CDD:394886"
misc_feature order(9300..9323,9330..9332,9639..9641,9651..9671,
9696..9710,9783..9785,9801..9803,10134..10136,
10146..10148,10170..10175)
/locus_tag="D425_gp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394886"
misc_feature order(9363..9371,9411..9413,9429..9431,9705..9722,
9774..9785,9801..9803,9846..9863)
/locus_tag="D425_gp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:394886"
misc_feature 10149..11024
/locus_tag="D425_gp1"
/note="alphacoronavirus non-structural protein 6; Region:
alphaCoV-Nsp6; cd21558"
/db_xref="CDD:394844"
misc_feature 11025..11273
/locus_tag="D425_gp1"
/note="alphacoronavirus non-structural protein 7; Region:
alphaCoV_Nsp7; cd21826"
/db_xref="CDD:409252"
misc_feature order(11028..11030,11037..11048,11055..11063,11067..11072,
11079..11081,11106..11108,11115..11117,11133..11135,
11169..11186,11190..11207,11226..11240)
/locus_tag="D425_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409252"
misc_feature 11274..11858
/locus_tag="D425_gp1"
/note="alphacoronavirus non-structural protein 8; Region:
alphaCoV_Nsp8; cd21830"
/db_xref="CDD:409257"
misc_feature order(11289..11291,11298..11303,11307..11312,11322..11324,
11448..11450,11457..11462,11469..11471,11481..11483,
11490..11492,11508..11510,11520..11525,11529..11573,
11577..11579,11583..11585,11589..11594,11601..11606,
11610..11612,11616..11621,11628..11636,11718..11723,
11841..11843)
/locus_tag="D425_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409257"
misc_feature 11859..12182
/locus_tag="D425_gp1"
/note="alphacoronavirus non-structural protein 9; Region:
alphaCoV_Nsp9; cd21897"
/db_xref="CDD:409330"
misc_feature 11859..11876
/locus_tag="D425_gp1"
/note="N-finger; other site"
/db_xref="CDD:409330"
misc_feature order(11880..11882,12060..12062,12129..12134,12141..12146,
12153..12158,12162..12167)
/locus_tag="D425_gp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409330"
misc_feature 12183..12572
/locus_tag="D425_gp1"
/note="alphacoronavirus and betacoronavirus non-structural
protein 10; Region: alpha_betaCoV_Nsp10; cd21901"
/db_xref="CDD:409326"
misc_feature order(12183..12206,12216..12218,12222..12230,12234..12245,
12255..12260,12267..12272,12279..12281,12300..12317,
12354..12359,12387..12389,12393..12398,12408..12410,
12414..12431,12444..12452,12459..12470)
/locus_tag="D425_gp1"
/note="Nsp14 interface [polypeptide binding]; other site"
/db_xref="CDD:409326"
misc_feature order(12222..12230,12234..12242,12255..12257,12300..12302,
12306..12317,12354..12362,12414..12425,12432..12434,
12465..12470,12522..12524)
/locus_tag="D425_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409326"
misc_feature order(12243..12248,12255..12257,12306..12317,12354..12362,
12432..12434,12465..12470,12522..12524,12534..12536)
/locus_tag="D425_gp1"
/note="homotrimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409326"
misc_feature order(12300..12323,12354..12359,12387..12398,12411..12416,
12420..12422,12459..12470)
/locus_tag="D425_gp1"
/note="Nsp16 interface [polypeptide binding]; other site"
/db_xref="CDD:409326"
misc_feature join(12603..12617,12617..15373)
/locus_tag="D425_gp1"
/note="alphacoronavirus RNA-dependent RNA polymerase, also
known as non-structural protein 12: responsible for
replication and transcription of the viral RNA genome;
Region: alphaCoV_RdRp; cd21588"
/db_xref="CDD:394892"
misc_feature order(13382..13396,13544..13549,13553..13555,13559..13573,
13589..13600,13607..13609,13679..13681,13688..13693,
13697..13702,13709..13711,13715..13729,13733..13753,
13763..13765,13769..13771,13781..13786,13796..13798,
14090..14095,14102..14104,14117..14122,14126..14128,
14135..14146,14573..14575)
/locus_tag="D425_gp1"
/note="putative Nsp8 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:394892"
misc_feature order(13802..13816,13820..13822,13835..13837,13862..13864,
13868..13870,13895..13912,14225..14227,14231..14233,
15104..15106)
/locus_tag="D425_gp1"
/note="putative Nsp7 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:394892"
misc_feature order(14069..14071,14075..14083,14210..14212,14246..14248,
14252..14254,14270..14272,14282..14284,14294..14296,
14306..14308,14345..14347,14351..14353,14357..14359,
14621..14632,14639..14641,14849..14860,15014..15019,
15071..15073,15095..15097,15146..15151,15161..15163,
15167..15172)
/locus_tag="D425_gp1"
/note="putative RNA binding site [nucleotide binding];
other site"
/db_xref="CDD:394892"
misc_feature 14075..14116
/locus_tag="D425_gp1"
/note="conserved polymerase motif G; other site"
/db_xref="CDD:394892"
misc_feature 14189..14257
/locus_tag="D425_gp1"
/note="conserved polymerase motif F; other site"
/db_xref="CDD:394892"
misc_feature order(14222..14224,14615..14623,14636..14638,14648..14650,
14852..14854)
/locus_tag="D425_gp1"
/note="inhibitor binding site [chemical binding];
inhibition site"
/db_xref="CDD:394892"
misc_feature 14408..14458
/locus_tag="D425_gp1"
/note="conserved polymerase motif A; other site"
/db_xref="CDD:394892"
misc_feature 14615..14704
/locus_tag="D425_gp1"
/note="conserved polymerase motif B; other site"
/db_xref="CDD:394892"
misc_feature 14834..14878
/locus_tag="D425_gp1"
/note="conserved polymerase motif C; other site"
/db_xref="CDD:394892"
misc_feature 14900..14965
/locus_tag="D425_gp1"
/note="conserved polymerase motif D; other site"
/db_xref="CDD:394892"
misc_feature 15005..15040
/locus_tag="D425_gp1"
/note="conserved polymerase motif E; other site"
/db_xref="CDD:394892"
misc_feature 15374..15658
/locus_tag="D425_gp1"
/note="Cys/His rich zinc-binding domain (CH/ZBD) of
coronavirus SARS NSP13 helicase and related proteins;
Region: ZBD_cv_Nsp13-like; cd21401"
/db_xref="CDD:439168"
misc_feature order(15506..15508,15569..15571,15575..15577,15614..15616,
15641..15655)
/locus_tag="D425_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:439168"
misc_feature 15668..15811
/locus_tag="D425_gp1"
/note="stalk domain of coronavirus Nsp13 helicase and
related proteins; Region: stalk_CoV_Nsp13-like; cd21689"
/db_xref="CDD:410205"
misc_feature order(15677..15679,15764..15766)
/locus_tag="D425_gp1"
/note="key interaction residues; other site"
/db_xref="CDD:410205"
misc_feature 15821..16060
/locus_tag="D425_gp1"
/note="1B domain of coronavirus SARS NSP13 helicase and
related proteins; Region: 1B_cv_Nsp13-like; cd21409"
/db_xref="CDD:394817"
misc_feature order(15905..15910,15914..15916,16010..16012)
/locus_tag="D425_gp1"
/note="nucleic acid substrate binding site [nucleotide
binding]; other site"
/db_xref="CDD:394817"
misc_feature 16022..16030
/locus_tag="D425_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:394817"
misc_feature 16127..17146
/locus_tag="D425_gp1"
/note="helicase domain of alphacoronavirus non-structural
protein 13; Region: alphaCoV_Nsp13-helicase; cd21723"
/db_xref="CDD:409656"
misc_feature order(16229..16246,16586..16588,16703..16705,16988..16990,
16994..16996,17075..17077)
/locus_tag="D425_gp1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:409656"
misc_feature order(16238..16243,16496..16501,16586..16588,17075..17077)
/locus_tag="D425_gp1"
/note="putative active site [active]"
/db_xref="CDD:409656"
misc_feature 17177..18706
/locus_tag="D425_gp1"
/note="nonstructural protein 14 of alphacoronavirus;
Region: alphaCoV_Nsp14; cd21660"
/db_xref="CDD:394959"
misc_feature order(17177..17179,17183..17194,17219..17248,17315..17317,
17327..17329,17342..17365,17465..17470,17534..17536,
17540..17542,17552..17557,17738..17740,17747..17752,
17759..17767,17810..17812)
/locus_tag="D425_gp1"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394959"
misc_feature order(17432..17434,17438..17440,17735..17737,17963..17965,
17978..17980)
/locus_tag="D425_gp1"
/note="ExoN active site [active]"
/db_xref="CDD:394959"
misc_feature order(18035..18037,18077..18079,18086..18091,18098..18100,
18158..18169,18173..18175,18212..18220,18245..18253,
18296..18310,18344..18346,18401..18403,18407..18412,
18419..18421,18425..18427,18647..18649)
/locus_tag="D425_gp1"
/note="N7-MTase active site [active]"
/db_xref="CDD:394959"
misc_feature 18719..18901
/locus_tag="D425_gp1"
/note="N-terminal domain of alpha- and beta-coronavirus
Nonstructural protein 15 (Nsp15), and related proteins;
Region: NTD_alpha_betaCoV_Nsp15-like; cd21171"
/db_xref="CDD:439163"
misc_feature order(18719..18727,18779..18781,18785..18796,18818..18820,
18833..18835,18860..18862,18866..18877)
/locus_tag="D425_gp1"
/note="hexamer interface [polypeptide binding]; other
site"
/db_xref="CDD:439163"
misc_feature order(18743..18760,18797..18808,18812..18814,18821..18823,
18827..18844,18851..18862,18899..18901)
/locus_tag="D425_gp1"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:439163"
misc_feature 18902..19249
/locus_tag="D425_gp1"
/note="Coronavirus replicase NSP15, middle domain; Region:
CoV_NSP15_M; pfam19216"
/db_xref="CDD:437053"
misc_feature 19274..19729
/locus_tag="D425_gp1"
/note="Nidoviral uridylate-specific endoribonuclease
(NendoU) domain of coronavirus Nonstructural Protein 15
(Nsp15) and related proteins; Region:
NendoU_cv_Nsp15-like; cd21161"
/db_xref="CDD:439158"
misc_feature order(19298..19300,19304..19306,19412..19420,19484..19486,
19496..19501,19505..19507,19526..19528,19532..19534,
19538..19540,19544..19546,19550..19555,19559..19561)
/locus_tag="D425_gp1"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:439158"
misc_feature order(19394..19396,19406..19408,19430..19435,19439..19441,
19562..19564,19571..19576,19715..19717,19721..19723)
/locus_tag="D425_gp1"
/note="putative active site [active]"
/db_xref="CDD:439158"
misc_feature 19736..20629
/locus_tag="D425_gp1"
/note="Coronavirus NSP13; Region: NSP13; pfam06460"
/db_xref="CDD:399456"
gene 20641..24690
/locus_tag="D425_gp2"
/note="S"
/db_xref="GeneID:13842716"
CDS 20641..24690
/locus_tag="D425_gp2"
/codon_start=1
/product="spike glycoprotein"
/protein_id="YP_006908642.1"
/db_xref="GeneID:13842716"
/translation="MISLAVFIAEILVIITRFSCLADQCQGTPWLAKNLNLGLSPNLT
NVYVPGLLPTKDTTKWYCRTESYFFTGYKGVFLSYHSFGMPWSIGVSNSDLSVARETW
SLYVSHGNNRGVMTFRICKWPRVPGLAQEPTPNTGGVNCVVDKQFPFTFQHEANEMVG
ITWSSDYVRIYGLQSTYRFYFPNKWNKVNVNCAHKSSCQVYPVKDSVTWVVNTTADGR
VKDYTICGSCNGFPQHVFPVSPGGLIPPDFSFDGWYVLTNSSTMVQGKFVASQPLKLL
CLWPVPALDSSASVVYFNLSRSSAQCNGATENGLADALRFSMNFSRNGFSGAHSLTLK
GAIDYVFRCTNNTNVTSFYSIPFGYIKTVYRCFVSYNSTNGTVSEFVGVLPPLVKEIV
VSRYGTIYLNGVRIFKLPPLEGVVFNVTSDVGSDFWTVAFAQNAEVLLEVNATNIVNL
HYCDNTLNKVKCQQLSFQLPDGFYPTTNLVDSVVPKTYVALPYHATHTYIELNITVNY
VRDEIALTGGGELTCVNTTQFTTLFSTNAATDGNTYEGVVINVNCPFDFDNLNNYLSF
DSICFSLKPIAGGCTMRLVKQILVSYFDIGVLYVSYTPGSKITGVLQPTGGVYDPSIV
HMGVCTDYVVYGLTGRGVISVSNTTYIAGLYYTSFAGQLLGFKNSTTGVLYAVEPCDT
SSQVAVYGDAIIGAMTSSANVTFGFVNTTVLPSFYYHTNGFGGCQTPVLEYGSMGLCA
DGSVVDVTLRQYQPAPVSPIATTNISIPLNFTISIQTEYIQMYSQQVSVDCSMYVCNG
NVRCLRLLTQYATACRNIESALQLSARLESLEVSSVVSVSENALKLANITHFDSYNLS
VLLPKSDGKSVVEDILFDKVVTSGLGTVDQDYKNCVGKLGVAQDIADVGCAQYYNGIM
VLPGVVNEAKMGLYTASLTGAMVMGGFTAAAAIPFSLAVQSRLNYVALQTDVLQQNQK
LLADSFNNALSNITLAFSNVNDALQDASEAINTVAVALGKVQGVVNEQGQAIAHLTQQ
LTQNFQAISHSIADIYNRLDELAADAQTDRLITGRLSALNAFVTQTLTKSAEVKQSRL
LAQQKVNECVKSQSNRFGFCGNGTHLFSIVNNAPNGLMFFHTVLVPTVYVTVSAWAGV
CFNNRAYILRDVESVLFNNNGYYVTNRKMYEPRVPQFSDFVQVENCVVSYLNLSDVDV
NTVIPDYIDVNKTLEDLLQQLPNHTLPDLGLDQYNNTILNLTAEIDILQNKSDLLLAS
TERLQQLIDNLNKTYVDLEWLNRFEQYIKWPWYVWLAILLAIILFSFLMLYCCCATGC
CGCLSCLTNSCDCRGKNLQRYEVEKVHIQ"
misc_feature 21304..22473
/locus_tag="D425_gp2"
/note="Coronavirus S1 glycoprotein; Region: Corona_S1;
pfam01600"
/db_xref="CDD:426339"
misc_feature 22498..24489
/locus_tag="D425_gp2"
/note="SD-1 and SD-2 subdomains, the S1/S2 cleavage
region, and the S2 fusion subunit of the spike (S) protein
from alphacoronaviruses; Region:
alphaCoV_Spike_SD1-2_S1-S2_S2; cd22369"
/db_xref="CDD:411956"
misc_feature order(22873..22908,22912..22935)
/locus_tag="D425_gp2"
/note="S1/S2 cleavage region; other site"
/db_xref="CDD:411956"
misc_feature 23191..23217
/locus_tag="D425_gp2"
/note="fusion peptide; other site"
/db_xref="CDD:411956"
misc_feature 23236..23289
/locus_tag="D425_gp2"
/note="internal fusion peptide; other site"
/db_xref="CDD:411956"
misc_feature 23545..23784
/locus_tag="D425_gp2"
/note="heptad repeat 1 [structural motif]; Region: heptad
repeat 1"
/db_xref="CDD:411956"
misc_feature 24322..24447
/locus_tag="D425_gp2"
/note="heptad repeat 2 [structural motif]; Region: heptad
repeat 2"
/db_xref="CDD:411956"
gene 24690..25346
/locus_tag="D425_gp3"
/note="NS3"
/db_xref="GeneID:13842717"
CDS 24690..25346
/locus_tag="D425_gp3"
/codon_start=1
/product="non-structural protein NS3"
/protein_id="YP_006908643.1"
/db_xref="GeneID:13842717"
/translation="MTGLFQTSFGDSVQAGVQHLVEKLPLPDVHFQHALPLANFLMTS
VFVIYFAMYKASSVRNNCIMFGFRLFAMFVYAPLLCYFELYVDAAIIFGALYTRLMYV
TYYACRYRSPAFVVLNTDKLAFVQGYYWYYQDNSYLTLLGGENFVTFGPNFVPIAATN
DLYIALRGKKDDDVPLVRRVELINGQFFYIFAQEPVVGVVNMCFSELRLCEEVEVQSD
"
misc_feature <24807..25334
/locus_tag="D425_gp3"
/note="ORF3b coronavirus protein; Region: Corona_NS3b;
pfam03053"
/db_xref="CDD:251695"
gene 25375..25602
/locus_tag="D425_gp4"
/note="E"
/db_xref="GeneID:13842718"
CDS 25375..25602
/locus_tag="D425_gp4"
/codon_start=1
/product="envelope protein"
/protein_id="YP_006908644.1"
/db_xref="GeneID:13842718"
/translation="MMFTLVNDNGMIVSAILWLVVLLFVLLIAVTVIKLIQLCFTCHK
LMSNTIYVPVYSAYVMYKNFMQIDPCPVIDV"
misc_feature 25378..25599
/locus_tag="D425_gp4"
/note="Non-structural protein NS3/Small envelope protein
E; Region: NS3_envE; pfam02723"
/db_xref="CDD:426939"
gene 25608..26297
/locus_tag="D425_gp5"
/note="M"
/db_xref="GeneID:13842719"
CDS 25608..26297
/locus_tag="D425_gp5"
/codon_start=1
/product="membrane protein"
/protein_id="YP_006908645.1"
/db_xref="GeneID:13842719"
/translation="MSNGDNSTIPTDVVIQHLRNWNFSWNVILTIFLVVLQYGHYKYS
AVLYILKMTILWLLWPLVLALSIFDSWSSFGNNWTMFAFSILMACITLVLWIMYFVNS
FRLYRRTNTFWAFNPETDAIITLSVFGRQVSIPALVAPTGITLTVLSGTLLVEGIKVA
TGVQVNQLPTYITVAKPSTTIVYQRAGRSLNTRSNTGWAFYVRSKNGDYSAVTSSADS
LTEDEKLLHLV"
misc_feature 25626..26279
/locus_tag="D425_gp5"
/note="alphacoronavirus Membrane (or Matrix) protein;
Region: alphaCoV_M; cd21564"
/db_xref="CDD:394850"
gene 26308..27516
/locus_tag="D425_gp6"
/note="N"
/db_xref="GeneID:13842720"
CDS 26308..27516
/locus_tag="D425_gp6"
/codon_start=1
/product="nucleocapsid protein"
/protein_id="YP_006908646.1"
/db_xref="GeneID:13842720"
/translation="MASGGNNVSFANKPRGRSGKVPLSYYSPVMIDGDQPFWKVMPTN
AVPTGMGDKNQQIGYWNEQPRWRMVKGQRKELPSKWHFYYLGTGPQEDARYRQRIEGV
FWVAVQGSKTDPTGLGTRRKGQDLISPKFAVKIPSNVMIVEETSRPPSRSQSNSRPQS
RNNSRPQSKNNSQNNSRDNSRAPSRPRSRANSTSSTTNDAVDIVAAVKQALKELGVTP
EKKNQEKQKKSKKSNSGSNTPKEAATPKQKSSPSTPRKQLERPEWKRVPNKEENVTAC
FGPRDTLHNFGDQKLIAEGVQASHYPQLAELVPTPAALLFGGEVSTRERGDEVEIMYV
YKMKVHKSNKDLPAFLQQVSAYAQAPDATTTEKATVQPLLNPTAPDFQPATSEEVIEM
INTVYDSFDA"
misc_feature 26347..27456
/locus_tag="D425_gp6"
/note="Coronavirus nucleocapsid protein; Region:
Corona_nucleoca; pfam00937"
/db_xref="CDD:425955"
misc_feature order(26368..26391,26542..26544,26548..26550,26554..26556,
26665..26667,26683..26685)
/locus_tag="D425_gp6"
/note="RNA binding site [nucleotide binding]; other site"
/db_xref="CDD:439219"
gene 27532..27777
/locus_tag="D425_gp7"
/note="NS7a"
/db_xref="GeneID:13842721"
CDS 27532..27777
/locus_tag="D425_gp7"
/codon_start=1
/product="non-structural protein NS7a"
/protein_id="YP_006908647.1"
/db_xref="GeneID:13842721"
/translation="MHVLIIIICFYLQCFLWALQPLFEACAYHWPVCVYVPSTISYCY
SVLGFSLIVIGCLFSALVLDVLGLIALKCLLVCRFLN"
gene 27787..28248
/locus_tag="D425_gp8"
/note="NS7b"
/db_xref="GeneID:13842722"
CDS 27787..28248
/locus_tag="D425_gp8"
/codon_start=1
/product="non-structural protein NS7b"
/protein_id="YP_006908648.1"
/db_xref="GeneID:13842722"
/translation="MKLLLLLSILSFSSAAPTTYRASQAAKVLIYTTEKVTLNNQRTH
SYTKWGVCSTGWNTYTNTMVVVNGRWVETTKPPRPTAIAIPTFPYEPRSEKPGFGSHF
DYGRIEYESILCAAFEHVSNDIAKIAAQLAQTQRRHQTFAVTTFRWSTPSN"
gene 27986..28216
/locus_tag="D425_gp9"
/note="NS7c"
/db_xref="GeneID:13842723"
CDS 27986..28216
/locus_tag="D425_gp9"
/codon_start=1
/product="non-structural protein NS7c"
/protein_id="YP_006908649.1"
/db_xref="GeneID:13842723"
/translation="MVGGLKQPNRQDPQPLLFQHSHTSLEVKNQVLVLTLTMAVLSMR
VSCVLHLSMSVMTLQKLLLNWLRHSDDIRLSL"
3'UTR 28249..28494
ORIGIN
1 acatggggac ttattgtgat tttctatctg cggatagtaa gtgtcactac ttagaccttg
61 tgtctcctca tctcaactaa acgaaatttt atccatcgca cacatgttcg catgtgtttg
121 cgtatggtgc aattgaaatt tcattaggtt gcctaatttg ggtaacaagt gcagtgcgtc
181 ctagtggctc tgagtgaggg ttccgtcccc tctcatccat tacaaacgcc ctttgccagt
241 tccgtctggt gaagtgtgtg gaagtcaagt tccgtcttgt ctgaaacctg taactgtgcc
301 caatggctag caaccaattg acattggctt ttgccaatga ctccgagatt tcagcttatg
361 gctttgacac cgtcgagcat gccgtggcac aatatagtgc tgccgcagct aacggttttg
421 ctcaatgccg atttgtcatt actggcctgc aagacttggt tgtgggtgtt aacgatgaag
481 agtttgttct tgtcgtgact ggcttgcacc aactcacagc ccgtattggc aaattcggtg
541 accaacccca aaacttacgt ggttggttgc tgttctccaa ctccaactac ttcttaggtg
601 agttggatct tatttttggc aatcgcggtg gtaccactgt ttttgtcgat aactttttgt
661 gtggtgctaa tggtcttcca gcttgttctg aacaagaatg ggagtttaaa gactattttg
721 gtgaacttga tgaagtcatc attaatggca ccacttttgt taaagcatgg aatgtggacc
781 gtacaccagg accttattca acccaaaact tgctttccat taactctatt tcttggtgtg
841 gtgaaatccc acactcactt gctgacggtt ctattcgtag ggttgctaaa gtggtgaaaa
901 agagtaagag tgttttgctt ggcaaacagt ttcaacaatt gtatgacagt gttggttctc
961 cttttgttac taatggtaaa aaccttactg atgtgcttgt gaagccaatt tattgtcatg
1021 ctcttgttaa atgccaatgt ggcaaaacat catggactgt tggtgattgg agttgttata
1081 agtctatgtg ttgtggtttt aactgtaaac cccttgccat tgtcaacgga gaagtcgtcc
1141 ctggtgatgt tctcgttacc agcgacaagg tatctgcctc cggaactaag tactataatg
1201 gtatggtgct taagtttgtg gacaaaattg acaatgcttg cttgtggaga attacacaag
1261 ttcagagttg catggatgtt gttgcgtccg gcaattacaa gggagatgaa ttcatctatc
1321 acactgatga tatttgcagt ccgactaata tgtctaaaat atctcatgct tttaaattat
1381 gttacttcac aggttcttac acagatgaag taaaatctgc tctactccat ggtgagttcg
1441 atgtttgcac aaacatctgt gatgtttcag accattcaat tcacaagcct tggtttgtgc
1501 gtgagatgga ggaacttctt ggaggagcat gggacaactt tgttaaggct gttaagtcct
1561 tatctgtctt gaacagtcaa ctgttcgacc ttatgagtgg tcttgctaag gctactatta
1621 gggttgtaaa tggctgcatt gagttttgtg ccaatattcc tacatgcttt aacgatgctt
1681 ttgagtgtct taagagcttt gtggaaacac tttttgacct tacagttaat actgtaacat
1741 ttgctggtca gtcttttaag gctgtcggtg attatgttct tcttaacaat gccattgtta
1801 agtttgtatc tgtaaaggtt aaaggtttac accaggatgg cattaagagt actatgtatg
1861 ccactacagt tgttggtaaa acagctaaag ttaagtcccg tagaattgaa acgtgcaatg
1921 ctaatctgag tgttgtacct gaccaagcac ttgttaaaga cggtgttacc aagattattg
1981 gtggacgttc gttcttttgt agtggaggtt gttatcgctt gatgagtgat gtggatactg
2041 ttattatgtc acctgtttac caagctgttg cacccactga agttgtgttc aactgtgtta
2101 aacctgctgg ttttgtggat cctgtgtgta gcactcttcc tgaacttgtc agtgatgtga
2161 ctaaacaatt attgcccttg aacaaacctt accgtttcta cgacgttaag gttaaagatg
2221 gcatgtgtat tgttacacaa gagaccacat ttagagcacc atcttatatt gcaaacagtg
2281 cgctgtttgt gcagctttgt gaagagtgcg tggatgttca aggttttgat gatttctacg
2341 taaaggcaca tgaagctacc agtttgagcc aattcgaacc tatgtttcct gcttttcaac
2401 agtttgtaaa aagtgttgat tgcccccaaa tattgaagga tattgatggt ggtggcattt
2461 ggaagacatt tattcagact gtttctgatg ctgttgagtt cgtaaaatct attaaggtag
2521 attttggact agacggtatt attattacag ctacaaagag gttcaagaaa tttgcaggca
2581 ttctccttaa tttgtacaga gagtttattg cttctgttac aagtgtggtt aagattggtg
2641 gtaagagttt tacttactac ttgtttgaga agcctaaaat ggccatttct ggtattttgc
2701 ataatgtgcg tgttcttaag gctaaagatt gcactattgc tgctgaagat atccttgttg
2761 aaatgactgt ttttgacagc tttgaaatac ctattcaacc atctcgtgtt gaagttcagc
2821 aagtcgaatt tgaagaggca gaatttgtgc aaccacaggc tggtggtgtt cttgctgttg
2881 ttaacaaaca tgtgttttac aataagggcg actactatta ccctgccaat gaaacacatg
2941 ctgtgcctgt atgctacaaa agaggtagtg gtactaatgg cactgttgta aaattctctg
3001 aagcagttca ggttaaagag atagaacctg tccatcgtgt taaacttgaa tatgagtttg
3061 aagatgaaac tattgtagaa atatgcaaga aagtcattgg aaaacgttac aagtttacag
3121 gtacagagtg ggaagaactt tgtagttaca ttcatagtgt aatgaaaaca gtatcagacc
3181 acattgaagt acctgagtac tttgtctatg atgaagaagg tggaaatgat tttacaaaag
3241 ttgttatggt ttctcagtat tcaattgctg atgaacagcc tgaaaatgtg gggcaaacgg
3301 atgttcttaa agaagagcag acagttgaag ccacatccaa atcacaggtt gtacaaccat
3361 tgaaacaaca agaacccgta aaaccacaaa agtctcaaat tgaagaagtt aatgaagctc
3421 ttagttttat gcttgaacca gtacaacaga aacctaaagt taatcctttt aattttgaat
3481 tctatgacta taagggcatt agagttctta aacagaagga taacaattgt tgggtttcgt
3541 ctacattggt tcaattgcaa ttattggatt gctactctga tcctgcattt gacttgttca
3601 aggcaggtag tgttgcaccg atagtacaaa agtgctatga gctcacacga aacattgtag
3661 gttctgctgg cgatgtttct tttgctttag aacaacttct taaagacttg cacacaatgt
3721 ttataacatt tgatgttgtg tgtggttgta acaacggtga aaggcgccaa tcagagctta
3781 gtggttgtgt gtttaggttt ttacctacat ctgaaccatt tgcctatggt ggctgtccat
3841 cttgtgataa acctcttatg cacactataa catctatgca aggtactggt gtgttttgcc
3901 aagatcctaa agctgtggat gttactacgt tgttggttca acctatgtgt gcttctgctt
3961 tcattggcaa ttggtttaat aactcgcttg gtcattacaa aacaaatgtt tatgacaagg
4021 ggttttgtgt tgacggtaat ggatcatggc ctatcacttt gaacaccttg aacactattt
4081 gttacaagga tgtcaattat gttagaccac ttcctgttgt gtctgatcaa ccaattgttg
4141 aagagaaaac taaacaagat gaattaaaac cttttgcaac ttatagaaat gttgaattct
4201 acaagggtga gatatcggac cttgtgcaac ttaaacatga ctttgtggtc aatgctgcta
4261 atgagaattt gagtcatggt ggtggtgttg ctgcagcgat aaacaatctt actaaaggtt
4321 tgttacaaac gttgtcagac cattatgtga agaaaaatgg caaaataaaa gttggacagg
4381 gtgttatgtt acattgtggt aaggaaaacg tcttgaatgt tgttggacca cgtaaaggta
4441 agcattcacc tcaattgctt gagaaagcct acaagtttgt tttaaaacaa aaaggcacac
4501 cacttacacc acttcttagt gtaggtatct ttaaagtacc tattttggag tctgttacag
4561 ctttaaaaaa tgttgttggc gaccgtcatg ttaaatgttt ttgttactca gttgcagaag
4621 tctctgagat acagaaatgt cttgacaatg atgtggttga acctaaaatg gaagtcccac
4681 agattgaatc tgagacggtt atatctgtgt cacaaaacac agaacaacaa gcattttcac
4741 atgtggatag aagggaactt aaaccttgca gagttgaggg taagttttca ttttatgatt
4801 gtcctattgc tgacattgct atcacagaac ctgagagagt tgtcttcttt acagatgtta
4861 aacttagttt ttgtgaggca gcaaaagcat tagacaaaca ttatgaaggt gctttgacta
4921 gctgtgtaca ggcctattta gctgagacac cattgattcc tgctggtaat ttgttaactt
4981 tgaagtgtga aggtgccatt cctgttagtt ttgctgttct gccagataca gatgcagcaa
5041 attataacaa ggatgttaaa cgcacattga caaaagtgtc aaagttaaaa ggcaaaatat
5101 tttgcacgat accaacagta gatgttatga aacaaatgct taagtgctgc aacacaagtt
5161 ttattgtaac tgatgctacc aaaactcgat tgtcagagtg ttttgagtct gcagtagtag
5221 aagttaaagt tacacatgac ggtcgtgatg tgcacaccgt caaggttaag actgatgttg
5281 tacttgacga gcaagttggt gtttgcagtt tgaataattg tgaccttact ggtgttaaac
5341 ctgacgatgc tattgtagat gttgttagtg tagctccaga agttgattgg atttcatatt
5401 atggctttcc tcgtgctgac ctttatcata cgttagatca taaacaatat gcgtatgaaa
5461 atagtgatgt tgaaggtaag cgtgttttga aattttctga caataattgc tgggttaaca
5521 ctatttgtct acagttacaa tttgctaaag ccattttcaa gactgagggt cttcaagcta
5581 tgtgggatga gtttctcaca ggtagagttg aaaggtttgt gcactggttg tactggtatc
5641 aaaatattga aaaaggtcaa cctggtgatg ttgagtattt gcttggtaaa ataagtcgct
5701 atctagtgaa tagtggtaca gtcaccattt caaaagattc ggtttgttgt aacagcaaac
5761 gtactcttac tacacctgtg gtagaagcta gtatccttaa gagtggtttt gatgatggtg
5821 tttgtaaaca tggtaatgct tgtgtgtcgc gtattagtgc tgttagaggt actgttattg
5881 tgattcaaac aggcaaacct aaagtttacc cacgtgctgc tctaattgat ggtgacacct
5941 acactacgta ttctggtagc gtagaagacg gtcattacac cgtttttgaa actaagaata
6001 gcagagtgta tgatggtgac accgtttcta ctggtaatga cctttctaca catgctgtgt
6061 cttctgttgt tgttgctaat aagttgttcg atgaccccat agaggttgtt gaaagagagg
6121 cttctagtat tgttaacaca ttagacactt ctgctgagaa gttcttttct tttggtgaca
6181 ttgtttctcg caattgtgtt acatttcttg tgtggttatt tagcatgttt agtttagctt
6241 ttaaggcttt taggactaga gatgttaaag ttatagctca agtaccgcaa agaacagggt
6301 taatattaag ccgcagttta aagtataatg ttaaagctac taacaagttt ttacagtcaa
6361 gaactaaatg ggttgttttg tttagtaaaa tgctattagt gctttctaca ttgtatgcat
6421 tgtggtttct tttattacga tttggtcctt tgcacgacac agtttgtaca agttatgttg
6481 aaggttattc taagtctaat tttgacaaaa atgctttctg tgaaaactta gcttgtaaaa
6541 cgtgtttgta tggttatgaa gagctttcag attttccgca cactgttaca acatggactc
6601 atttgggtga tccgcttttt aaaactttgt tgccacttat ttatatagca tttttgctta
6661 tatttggtgg tgttgttgtt cgtgggttca tgctttattt tgttgcgcaa tatgtcaacc
6721 aatttggtgt ggttttgggt ttccaagata gtgtctgggc ccttcagctt gtcccatttt
6781 caatttttgg tgacgaaatt gttgtgttgt ttttagttat aaagtttatg ttgtttttaa
6841 aacatgtttt ctttggttgt gaaaaacctt cttgtgttgc ttgttcaaaa agtgcacgtc
6901 taacacgtat tcctatgcaa actattgtta atggctctaa taggtcattt tacgtagttg
6961 ctaatggtgg taaaaaattt tgtgagaagc ataaattttt ctgtgttaat tgtgattctt
7021 atggacaagg caacacgttt attaatgatg tagttgctgc agaagtttct aatgtggtta
7081 aaaccaatgt tattgctaca ggtcctgctg ttatcgacat tacaaaggta gaattccaca
7141 acgggtttta ctatttgtat ggtgatgatg gcaagacatt ttggcgctac aactttgata
7201 ttacagaagg taaatacagc tgtaaagaag tgcttaagaa tagtaatgtt ttggcagatt
7261 ttattgttta caacaatgtg ggttcaaatt tggcgcaggt taagaatgct tgtgtttatt
7321 tctcacagtt actttgtaaa ccaatcaagc ttgttgatgc aactttgttg gcaacactga
7381 atgttgattt taatggtgcg ttgcacgcgg cttttgttga agttcttaac gaaagtttcg
7441 gtaaggacct taagagttgt tccacgatgg cagactgtaa aacagcgttg gatattgatg
7501 ctgatgatga agagtttgtc aatggtgtta gcaatgcaca tcgttacaat acattgttgt
7561 ctgatttgtc atacaacaac tttgttacat cttacgccaa accagaagaa aaactttcaa
7621 cccatgatct tgctgcttgc atgcgtggtg gcgctaaggt tgttaaccat aatattttag
7681 taaaggagaa tgtacccatt gtttggtatg ctaaagattt caacatgttg tctgaagaag
7741 gacgtagata tgttgttaaa actgccaaac ttaaaggtgt aaactttcta cttacattta
7801 atgacaaccg tatgcaaact caaatacctg tggttagtgt cacaacaaag tgcgggtctg
7861 gcattagacg atgttataat tacatctggt ggatctgtgc ttttattttg tgtgtgtttt
7921 tagctacagg atttgttgat tacacctcta tggttgtaag cgctagtgac tatgatttta
7981 ggtacattga aggtggtaag ctgaaagttt ttgaaacacc tttgaaatgt gtacataaca
8041 catttgctaa ttttgacaat tggtacaact caaagtttgg ttttactcct agtaaagaca
8101 aacgttgtcc gattgttgtt ggtgtttcta acgaggctag aacgatccct ggtgtgccgt
8161 cgggtgtttt tctttttggt aagacacttg tctttgcgct tcaaatagtt tttggaggtt
8221 cacacacatg ctatgacatg actggaccag ctcctttgga ccgctgtata ttcgactctg
8281 cctgtaccac acttaatggt ttgggcggtg agcgtgtata ttgttacaaa aacggtcttg
8341 ttgaaggttc tcttctttat acagacttgc aacctaatag ttattatagt ctcccagttg
8401 gtggttatgt tagactacca gaggttataa ctagtggttt aggttttagg actgtacgta
8461 cacaacaaac cacttattgc agaatgggag aatgtgttga ttcgaaggct ggtatttgtt
8521 ttggcgctaa taggtttctt gtttatagtg ctgaatcagg tacagacttc gtttgtggta
8581 caggtctctt gtctttgttg cttaatgtgt ttaatatgtt ttcttcttca ttttctgttt
8641 tggctatgtc cggtcaaatt gtttttaatt gtgtgcttac atgtgttata attatggctt
8701 gtttgcttgt cacaaaactt aaacgtatgt tcggtgatct ctcattggga gtgtgcactg
8761 ttgtttgtgt ggctattgtg aacaatttgt catatattat tacccagaat gctgtaatga
8821 tggtagtgta tgccattttg tactttttgt caactaggac tttcaagtat ggatggatat
8881 ggcatgtggg ctactgtatt gcttaccttt ctatggcacc atggtggttg ttgttctggt
8941 atatgtgttc agctttaatc ggcttagtac ctagtttgct taagttaaaa gttacttctc
9001 aactttttga tggtgacaaa tttgttggca attttgaaac ggctgctact ggcacatttg
9061 tgttggatat gcattcgtat caaagaattg ttaatagtat tgcacccgaa aagattaagc
9121 aacatgctgc tagttataac aagtataagt actatagtgg tgctgcttct gaagctgatt
9181 atagacttgc ttgttatgca catttggcta aagctgtttt agactatgga accaatcacc
9241 aagatacgtt gtacacacca ccaaccatta gttacaattc aacattgcaa tccggtttgc
9301 gtaagatggc gcaaccttct ggtgtggtgg agaagtgtgt tgtacgtgtt tgttatggta
9361 atatggcact taatggtttg tggctaggtg atgttgttat ttgtcctaga catgtgatag
9421 catcaaacac taacgcactt attgattatg aacatgagat tagtgttatg cgtttgcata
9481 atttctcagt ttcggttggt aatgtgtttt tgggtgtcgt tagtgctaca atgaagggtg
9541 ctaacttgca tattaaggtt aaccagacca atgttaatac tcctgaacat agtttcaaaa
9601 ccataaaaca gggtgagtct tttaacatcc ttgcatgtta tgatggtatg ccttctggtg
9661 tttatggtgt cactatgcgt aacaactata ctattagagg ttcttttatt actggtgctt
9721 gtggttcgcc tggttacaat gtaactaatg gcaaagttga attttgctac ttgcaccaat
9781 tagaacttgg tagtggttgt catgtaggtt caaacttaga aggtgttatg tatggttgtt
9841 atgaagatca acctacattg cagatagagg gtgttaacca tcttgtgact cctaatgtta
9901 ttgcatttct ttatggtgca ttacttaatg gtattacatg gtggttgaac tctgataaag
9961 tttctgtgga atccttcaat gagtgggctc ttaacaacgg ttttactaca tgtggtaacc
10021 tagactgttt taatatgctt tctgctaaga ctggtgtaga cgtgcaacgt ttattggcgg
10081 ctgtacaacg cttacacaat agttttggtg gtaaaaatat cctcggttat actactctta
10141 cagatgagtt tactgttggc gaggttatta agcagatgta tggtgttact ttacagagta
10201 ataaagttgt tggtgcgttt tgcaacttag ccattgtggg cctctttgtt acaatgtttt
10261 ggtctgaact tttacaatac acagcattct tttgggttag tcctggtttt gtgactcctg
10321 tgttctttgc actgttgtta gtgtccttta tacttatgtg ttttcttaaa cacaaagtgt
10381 tgtttttata cacttttctt ataccatcag tcataattat ggcaagttat aattttatgt
10441 gggactggtc tgtggcagct gaattggccc gcatcttcga ttaccatgtt tccattgtta
10501 gttttgacat tcaaggtttg ttgaatgttg ccgtatgttt gtttgtcact ctgttacata
10561 caatgcggtt tttcaaaaca aacacatcaa tttcaactta tgtattgtca ttggcattta
10621 ctgtttatgg ctttgttgtt ggttctgatg tgttgagtat tgttatgact ttgcttttta
10681 atttgacatc ttcgtggtat gttggtgcta ttgtttacaa attggcatat taccttcaat
10741 attatacatc atttgcacaa attttgggtt ctataaaagc tattatgctt tgttatatgg
10801 gccttggtta tttgtgctgt gtctattatg gctttttgta ctggattaac cgtttttgta
10861 aactatctct tggtgtttac gattttaagg ttagtgccaa tgagtttaaa tttatggttg
10921 ctaatggttt gcaagcaccg cgtggtgttt ttgatagtct ggcattgtca attaagctca
10981 tgggtattgg tggtgaaaag actattaaag tctcatctgt ccagtccaaa ttgaccgata
11041 ttaagtgtac aaatgttgtg cttcttggtt gtttgtctag tatgaacatt gctgctaaca
11101 ccaaagaatg gtcttattgt gttgatttgc ataataagat taatctttgt aatgaccctg
11161 aagctgcaca agaaatgtta ttggctctac ttgctttttt ccttagtaag cataaagatt
11221 ttggctttga tgatttgctg gattcttact ttgcagacaa ttctattctg caaagtgtgg
11281 catccacatt tgttaatatg ccgtctttta ttgcttatga aaatgcgcgt caagcttatg
11341 aagatgctat tgccaatgat tctgctcctc agttggttaa acaattgaag acagctatga
11401 acatagcaaa atctgagttt gatagggaag tttctgtgca aaagaaaatt tcgcgtatgg
11461 ctgaacaagc tgcagcgcag atgtacaaag aggctagagc tgttaacaga aagtctaagg
11521 ttattggtgc tatgcattca ttgcttatgg gcatgcttcg taagttggac atgtctaatg
11581 ttgacaccat acttaattta gcaaaagatg gtgttgtacc tctctctatt ataccagcag
11641 cttgttccac aaagttgaac gttgttagtg ctgatttaga ttcttattat aagatttgca
11701 gggatggttg tgtgcactat gccggcgtta tctggaatgt tatagacatt cgtgataatg
11761 atggtaaaat tgtacatgct aaagaaattg cacctgaaaa cgttgaaaac attgcttggc
11821 ccatttttct taactgcgaa cgcattgtta agttgcagaa taatgaaata atgcccggta
11881 agcttaagca gcgtcctgtt aaagctgagg gtgatggtat ttctgctgat ggtatggctt
11941 tgttcaacaa cgagtctggt aaaacgttta tgtatgcgtt tattgcagac aaacctgatc
12001 ttaaatttgt taaatgggaa tttgacaatg gatgtagtgt tatagaactt gaaccaccgt
12061 gtcgttttgc agtgcaaaca cctactggta ccactattaa gtatttgtat tttgtgcgca
12121 atttgaatac attgcgtcgt ggtgctgttt taggttttat tggtgcaact gttcgacttc
12181 aagctggtaa acaaactgaa cttgccgtta attccccatt gcttactatg tgtgcttttg
12241 cagttgaccc tgctaagact tacttggatg ctgtcaaaag aggtgctaaa cctgttggta
12301 attgtattaa aatgcttgcc aatggttctg gtactggaca ggccgtaact acgggtgttg
12361 aggctaacac taaccaagat agttatggtg gtgcgtctgt gtgtttgtat tgtagagcac
12421 atgttgaaca ccctagtatg gatggttatt gtaaactgaa aggtcgttat gtacaggtgc
12481 ctatgggaac aatagatcct ataagatttg tactagaaaa tgaggcctgt aaagtttgcc
12541 agtgttggtt aaataatggt tgtgcttgtg atagagtttc tacatctatg caagcttttg
12601 acaatggtta tttaaacgag caaggggctc tagtgcagct caactagagc cctgcaatgg
12661 cactgacact gatcattgtg tcagagcatt tgacatttat aacaaagatg ttgcatgtct
12721 tggtaagttt ttgaaaacga actgtgttcg tttcagaaac aaattacata aggatgcata
12781 ctttgttata aagagatgtc ctaagtctgt catggaacat gagcaatcca tatatgacat
12841 acttaaagat tctggagcca ttgcaacaca tgacttcttc gtatggaagg atggtcgcat
12901 gatttatggt aatattagta gacaagatct tactaagtat actatgatgg accttgtgta
12961 tgcattgcgc aactttgatg agaaaaattg tgaaactctt aaggagatac ttgttattac
13021 aggcgcgtgt gaccagtctt attttgataa taagttctgg tttgatcctg tagaaaatga
13081 agatctccat agagtttatg ccattttggg taaaatagta gcaaatgcca tgttaaaatg
13141 tgttcgttta ggtgatgcca tggttaaaca tggtatcgtt ggtgttatca ctcttgataa
13201 ccaagacctt aacggcaact tttatgattt tggcgatttt gctaaaacat tacctggtat
13261 gggtgttcct ttgtgtactt cttattactc ttacatgatg cctgttatgg gtatgaccaa
13321 ttgtcttgct ggtgaatgct ttattaaaag tgatattttt ggtagtgatt ttaagtcttt
13381 cgatcttttg cattatgact ttactgatca taaacaagca ttgttcgaaa agtactttaa
13441 gcattgggac caagagtatc atcctaattg tgtggattgc catgatgaac tttgtatagt
13501 tcattgtgcc aattttaaca cattgttttc caccactatt cccattacgg cttatggccc
13561 gctgtgtcgc aaagtttttg ttgatggtgt gccattagtc gctacagcag gttatcattt
13621 taaacaactt ggtattgtgt ggaataaaga tttgaacaca cattctacca ggcttactat
13681 taatgagcta ttacaatttg tgactgaccc atcgttgctt gttgcttctt caccagccct
13741 ggttgatcag cgtactgtgt gcttctcagt cgctgcacta ggtacaggta tgactaagca
13801 aactatgcaa cctggtcatt ttaacaagga attctatgac tttttgcgta aacaaggttt
13861 ctttgaagaa ggttctgaat taacactcaa acacttcttc tttgcgcaaa aaggtgatgc
13921 tgccattaag gattttgatt attataggta taacaaacct acaatgttag atgtctgtca
13981 ggcacgtgtt gcatacaaac ttgttagtcg ctatttcgac atttatgatg gtggttgtat
14041 aactgctaaa gatgttgtgg ttacaaacct caacaaaagt gctggttacc cacttaataa
14101 atttggaaag gctggtttgt attatgaatc cttgacttac gaagagcaag atgctcttta
14161 tgctgtcaca aagcgtaatg tgttgcctac tatgacacag ctcaacttaa agtatgctat
14221 tagtggtaag gaacgtgcac gcactgttgg tggtgtttct cttttatcca ctatgactac
14281 tagacagtac catcaaaaac accttaaatc tattgtgaat acacgcaatg cttctgttgt
14341 cattggtacc actaaatttt atggtggttg ggacaacatg ttaaacacgc ttattaatgg
14401 tgttgaaaac ccttgtctta tgggttggga ctaccctaag tgtgacagag cattgcctaa
14461 catgatacgc atgatctctg ctatgatact tggttccaaa cacacaacat gttgtactac
14521 tgatgaaaga tattatcgtt tgtgcaatga gttggcccaa gtgttaacag aggttgtgta
14581 ttctaatggt ggtttttatt ttaaacctgg tggtactacc tcaggtgatg cttctacagc
14641 ctatgctaac tcagtcttta acattttcca ggcagtcagt tctaacatta acagattgtt
14701 gactatcgac agcaatgttt gtaataatgt tagtgtcaaa actctgcaaa gagagttgta
14761 tgacaactgc tacaggtcat caagtgttga cgaacaattc atagataaat attattgcta
14821 tttacgcaaa catttttcta tgatgatttt gtctgatgat ggtgtagtct gttacaacaa
14881 agattacgca gaccttggtt atgtagcaga tattagtgca ttcaaagcta cattgtacta
14941 tcagaacaat gtctttatga gcacttccaa gtgttgggtt gaacctgaca ttactaaggg
15001 tccacatgag ttttgttcac aacacactat gcagattgtt gatgaaaatg gtaaatatta
15061 tttaccctat cctgatccat ctaggatatt gtctgcaggt gtttttgttg atgatgttgt
15121 taaaactgac gctgtcattt tgcttgaacg ctatgtttca ttggctattg acgcttaccc
15181 tttgtctaaa cacccaaatc ctgagtatcg taaagtattt tatgtacttt tagactgggt
15241 taaacatttg cataacacac ttaatcaagg tgttttagaa tctttctctg tcacattact
15301 agaagacacg tcttctaagt tctgggacga gagtttctat gccaatatgt atgaaaagtc
15361 agccatacta cagtcggctg gtttatgtgt agtgtgtggt tctcaaactg tacttcgttg
15421 tggtgactgt ttacgacgtc ccatgttgtg tacaaagtgt gcttatgacc acgtgattgc
15481 cacacctcat aaattcatat tggctataac gccctatgtg tgttcatatt ctggctgtaa
15541 tgttaatgat gtcactcaac tttatcttgg tggtcttagt tactattgtg ctgaacacaa
15601 acccagactt tcattccctc tttgttctgc tggcaatgtt tttggtcttt acaaagcttc
15661 agccactggt tctccagatg ttgaaatttt caacacactg gcaacttctg attggacaga
15721 tgttagagat tataaaattg ccaatgaagc taaggattct cttagactat ttgcagcaga
15781 aactattaaa gcaaaggagg aaagtgttaa gtcttcttat gcttgtgcaa cacttaaaga
15841 agttatagga cctaaagaat tactgctaag ttgggagtgt ggtaaagtta aaccacccct
15901 caacagaaac agtgttttta catgttttca tattacaaaa gactccaaat ttcaagtagg
15961 tgaatttgtt tttgaaaaag ttgattatgg ttctgatgct gttagttata agtccacttc
16021 tacgagtaag ttgtctcctg gtatggtgtt tgtgttaaca tctcataatg tacagccgct
16081 tcgagcacct accatagcaa accaggaacg ctactcatca attcacaaat tgtacccgtc
16141 cttcaacatt gccgacgctt actctacgct ggtaccttat tatcaaatga taggtaaaca
16201 gcgtataact acaatacagg gacctcctgg tagtggtaag tcacattgtg ttataggtct
16261 gggtttgtac taccctggtg cacgcatagt tttcacagca tgctctcatg cagctgttga
16321 ctctttgtgt gttaaggcat caactgctta tgtaaatgac cgctgttcta ggattattcc
16381 tgctcgtgct agagtggatt gtttcagtgg ttttaagtct aataacaata gtgctcagta
16441 cctcttttcc actgtcaatg cactacctga atgtaatgct gacatagttg tggtggatga
16501 ggtttcgatg tgcacgaact atgatttgtc tgtgattaac cagcgtttgt cttacaaaca
16561 tattgtttac gttggtgacc ctcaacaatt gcctgcgcct agaaccatga tcttgcgtgg
16621 tgttttagaa cctaaggatt ataatgttgt cacacaaaga atgtgtgctg ttggtcctga
16681 tgtcttttta cacaagtgtt atcgttgtcc agccgagatt gtgaaaacag tttctgagat
16741 ggtttatgat aacaagtttg tgcctgtaca tccagagagt aaacagtgtt ttaagctctt
16801 ctgtaaaggc aatgtgcatg ttgacaatgg ttctagcatt aaccgtaagc aattagatgt
16861 tgtcaaatta tttttggcta aaaatccatc ttggtctaag gcagtgttta tttcaccata
16921 caacagtcaa aattatgtgg ctagtagagc tctcggtctt cagatacaaa ctgtcgattc
16981 atcgcaaggc agtgaatatg attatgtcat ttttacacaa acatctgaca cacagcatgc
17041 ttgtaacgtt aatcgcttta acgttgccat tacacgtgct aagaaaggta ttttgtgtat
17101 aatgtgtgac aaagagctct ttgacgctct aaaatttttt gaaattaaac ttactgattt
17161 acaggctggt gaaggttgtg gtctttttaa agattgttct aggaaacccg atttattacc
17221 cccatcgcat gccaccacgt ttatgtcttt atctgataat tttaagacga gtggtgatct
17281 cgcagtgcaa gttggtgtga atggtgtttg taagtatgaa cacgtaattt cctttatggg
17341 atttaggttt gatactaaca tacctggtta ccacagtttg ttttgcacca gagactttgc
17401 tatgagacat gttagaggtt ggttgggtat ggatgttgaa ggcgctcatg ttgtaggcga
17461 caacatcggt actaacgtac ctttgcaggt gggtttttct aacggtgtgg attttgttgt
17521 ccaaccagaa ggttgtgtgg tcaacgagtt tggcacaaac attcaacccg ttagagctcg
17581 tgctccgcca ggtgaacagt tcgcacatct cataccactt atgcgtcgtg gtcaaccatg
17641 ggttgtcgtg cgtaaacgca tagtgcagat gtgttgtgac tatttgtctg gcttatcaga
17701 tgtgctcgta tttgttttat gggccggtgg tttggagttg actaccatga gatactttgt
17761 taaagtagga caagtcaagc attgtcactg ctctaaagag tctacttgtt acaatagtac
17821 aactcatgag tattattgtt tcaagcatgc acttggttgt gattatctgt ataatccttt
17881 tgttattgat atacaacagt ggggttatac aggctctttg agtttgaacc atcatgaggt
17941 ttgtaatgtg catcgtaatg aacatgttgc gtctggtgat gctatcatga cacggtgtct
18001 tgcaattcat gattgctttg tgaaaagtct tgactggtct attacatatc cattcattgc
18061 taacgagcgt gaaattaata gtggtggtcg tgttgttcag cgtatgctaa tgaagacagc
18121 cattaagttg tacaatccta aagcaatcca tgacattggt aatccaaagg gcatccgctg
18181 tgctgtaaca gatgctaagt ggttttgcta cgataggcaa cctttgaact ccaatgttaa
18241 attgtttgag tatgattata taacacacgg tcaactggat ggtttatgtt tgttttggaa
18301 ctgtaatgtt gacatgtatc ctgagttttc cattgtttgc cggtttgata ctagatgcag
18361 atccagcctc aatctagaag gcaccaatgg tggttcctta tatgtcaaca aacatgcttt
18421 ccacacacca gcttttgata aacgtgcttt tgctaagctt aaacctgcac ccttcttctt
18481 ttatgatgac ggtccttgtg accgcataca ggaagagatt aactatgttc cattgcgtgc
18541 tgctaattgc ataacacgtt gtaacattgg tggtgctgtt tgtagtacac atgctaagca
18601 gtactatgat tatgttaatg cttacaatag ctacactcaa gctggtttta cattatgggt
18661 tcctaataca tttgatcttt ttaatttgtg gcaaactttt gctgacacaa aattacagag
18721 tctcgaaaat atcgcatata atgtgattaa aaagggctct tttgttggtg agtctggtga
18781 gttaccagtc gccattgtaa atgacaaagt ttttgtgcga gaaggcactg ttgacaacct
18841 tgtctttgta aataaaactt cattacctgc taatgtggca tttgaacttt tcgctaaaag
18901 aaaagttggt ttaacaccac cccttagtgt actcagaaac cttggtgttg tgagtacata
18961 taagtttgtt ttgtgggatt atgaggcaga aagacctttt acttcattta caaagagtac
19021 gtgtagctac acagactttg atgaggatgt cacaacatgt ttcgataatg ctattgctgg
19081 ttcttttgaa cgctttacat tgactagaaa tgctgttttg atatctaatg tagctattaa
19141 gaaactagta ggcatgaaaa ttgcttatgg tttgcttaat ggtgttcctg tttctgtgtg
19201 tgaaaataaa cctgtcactt ggtacatata tgttcgtaag gatggacagt ttgtggatca
19261 gtatgacggt tactacacac aaggtcgtaa catagcagag tttttgccgc gtagtgatat
19321 ggaaaaagac ttcttagaaa tggacatggg catgtttata aataagtatg gtcttgaaga
19381 ctatgctttt gaacatgttg tctatggtga tgtctcaaaa actacacttg gtggcttaca
19441 cctgcttatt tctcaagtgc gtctacagaa aatgggtgtt cttaaaattg atgagttcac
19501 atctagtaat gatggtacgc tcaaaagctg cactgtcact tatgcaaaca atccaagtag
19561 caaaatggtt tgcacatata tggatttgtt gttagatgac tttgtaacaa tacttaaaaa
19621 tttggactta gatgttgtgt ccaaagttca ggaggttatt atagattgca aagtttggcg
19681 gtggatgctg tggtgtaagg gtcataaagt tcaaactttt taccctcaat tacagtctgc
19741 tgaatggaaa tgtggttatt ccatgccatc aatctacaaa atacaaagga tgtgccttga
19801 gccttgtaac ctctacaatt atggtgccag tatcaaatta cctgatggca tcatgttcaa
19861 tgtcgtgaaa tacactcaat tatgtcaata tttaaatagc actactatgt gtgtaccata
19921 caacatgagg gttttgcacc ttggtgcagg gtcggataag ggagttgcac ctggtaccgc
19981 agtcttacga agatggctgc caagtgatgc tattattgtt gacaatgatg ttgaagacta
20041 tgttagtgat gctgactaca gcattacagg tgattgttct acagtttact tagaagataa
20101 gtttgaccta gtcatatctg atatgtacga tggtaaaaca aaacactgtg atggtgagaa
20161 tgtttcaaag gaaggatttt tcgtttactt caacggtgtt ataaacgaga aacttgcact
20221 tggagcatcc gttgctataa aggtaactga atattcgtgg aacaagaaac tttatgagtt
20281 agttcaacga tttgagtttt ggacattgtt ttgtaccagt gttaatacgt cttcatccga
20341 agcgttttta gttggtatta attatcttgg gacctttagc gataagccag ttatagatgg
20401 taatgtagtt cacgccaatt acatattctg gcgaaattca acaattatgt cgatgtccta
20461 taatagtgtg cttgacctcg ccaagtttaa ttgtaaacat agagcaacgg cagtcataca
20521 acttaaagac agtgacatta atgatatggt ccttggtctt ataaaaagag gcaaaatact
20581 tgttagaatg aatgggactt atatgggttt ttctaaccat ttagtctcaa ctaaacaaag
20641 atgatttctc ttgctgtttt tatagcagag atacttgtta ttattacgag attttcgtgt
20701 cttgctgatc aatgtcaagg tacaccttgg ttagctaaga acttgaatct tggtttgtca
20761 cctaatttga ctaatgttta tgtaccaggt ttgttgccta caaaggacac cacaaagtgg
20821 tattgtcgca cagaatcata cttttttaca ggttataaag gtgtgtttct atcgtaccac
20881 agttttggta tgccttggtc tattggtgtt tccaattctg atctctctgt tgcacgtgaa
20941 acatggtcat tgtatgtttc tcatggcaat aatagaggtg ttatgacctt tagaatttgt
21001 aaatggccac gtgtgcctgg actagcacaa gaacctactc ctaacactgg tggtgttaat
21061 tgtgtagtag ataagcaatt tcctttcact tttcaacacg aggctaatga aatggtgggt
21121 attacttgga gttctgatta cgttcgtatt tatgggcttc aaagtaccta tcgtttttat
21181 tttcctaata agtggaataa agttaatgtt aattgtgcac ataagagttc ttgtcaggtc
21241 taccctgtta aagacagtgt tacatgggtt gttaatacca cagctgatgg acgtgttaaa
21301 gattacacta tttgtggttc ttgtaatggt tttccgcaac acgtcttccc tgtttcacct
21361 ggtggtttaa tacctcctga ttttagtttt gacggttggt atgttttaac caactcttcc
21421 actatggtgc aaggtaagtt tgttgcatct caacctttaa aattgttgtg cctttggcct
21481 gtacctgctt tggattctag tgctagtgtt gtttatttta atttatcacg tagtagtgcg
21541 caatgcaatg gtgctactga aaatggttta gccgatgcat tacgtttttc tatgaatttc
21601 tctagaaatg gtttcagtgg tgctcacagt ttgactttaa aaggtgccat tgattatgtt
21661 tttaggtgca ctaataacac taacgtaaca agtttttatt ctataccatt tggttatatt
21721 aaaacagttt acaggtgttt tgtatcctat aatagcacta atggcacagt gtcagagttt
21781 gtgggtgttt tgccacctct tgttaaagaa attgttgtct cacgttatgg caccatttat
21841 ttgaatggtg tacgtatctt taagttaccg cctttagaag gtgttgtgtt caatgtaact
21901 agtgatgttg gttcagactt ctggactgtt gcatttgcgc aaaacgctga agttttgttg
21961 gaagttaatg caactaacat tgttaatttg cactattgtg ataatacgct gaacaaggtt
22021 aagtgtcaac aactttcttt tcaattacct gatggttttt atcctacaac gaacctggtg
22081 gatagtgttg ttcctaaaac atatgttgct ttaccctatc atgcaacaca cacgtacatt
22141 gaattaaata taactgttaa ttatgtacgt gatgagatag cattaactgg aggtggtgag
22201 ttgacttgtg ttaatacaac acaattcacc acactcttct caactaatgc tgctactgat
22261 gggaacactt atgaaggtgt agttattaat gtcaattgtc cttttgactt tgacaacctt
22321 aataattacc tgtcttttga ctccatttgt ttctctttga aaccaatcgc tggtggttgc
22381 actatgcgac ttgttaaaca aattcttgtg tcatattttg acataggtgt tttgtatgtt
22441 tcctatacac ctggttcaaa aattactggt gttttacaac ctacaggtgg tgtttatgac
22501 cctagtattg ttcatatggg tgtttgtaca gactacgttg tttatggtct tactggtaga
22561 ggtgttatat ctgtcagtaa caccacttac attgctggtt tgtactatac atcatttgca
22621 ggacagttgt taggttttaa aaattctact acaggtgttc tttatgctgt tgaaccatgt
22681 gacacttcta gtcaagttgc cgtctacggt gatgctatta taggtgctat gacatcttct
22741 gctaatgtca cttttggttt tgttaacacc acagtgctac catcttttta ctaccacact
22801 aatggttttg gtggttgtca gacacccgtg ttagagtatg gttccatggg tttgtgtgct
22861 gacggtagtg ttgtagatgt tacattacgc caataccaac cagcgccagt ttcaccaatt
22921 gcaacaacaa acattagcat accattaaac ttcacaatct ccattcaaac agagtacata
22981 cagatgtact cacaacaagt ttcagttgat tgtagtatgt atgtttgtaa tggtaatgtt
23041 aggtgtttgc gtttactcac gcagtatgca actgcttgta ggaatattga aagtgcttta
23101 caacttagtg ctcgtttaga gtcgttagaa gtcagctcag ttgtttctgt ttctgaaaat
23161 gccttaaagt tggcaaatat cacacatttt gatagttaca atttatcagt tttgctgcct
23221 aaaagtgatg gtaaaagtgt tgttgaagac atactttttg ataaagttgt tactagtggt
23281 cttggtaccg ttgaccagga ttacaaaaat tgtgtgggta aacttggcgt tgcacaggac
23341 atagctgacg ttggttgtgc acagtattat aacggcatca tggtgttacc tggtgttgtg
23401 aatgaagcaa aaatgggttt gtatactgca tctttaacag gtgccatggt gatgggaggt
23461 tttacagctg cagctgctat accattttct ttggctgtac aatctcgtct taattatgtg
23521 gccttgcaaa ctgatgttct gcaacaaaat caaaagttgt tggcagactc ttttaataat
23581 gcactttcta atataacatt ggccttctcc aatgttaatg atgctttgca agatgcttct
23641 gaagccatta acacggttgc ggtggcatta ggcaaggttc aaggtgttgt caatgagcaa
23701 ggacaagcca tagcgcacct tacacaacaa ttaacgcaaa attttcaggc tatttcgcat
23761 tctatagctg atatttataa tagacttgat gaacttgctg ctgacgcaca aacagaccgt
23821 ttgataacgg gtcgtcttag tgcgttgaat gcttttgtta ctcaaactct aactaagtca
23881 gctgaagtta aacagagcag gcttttggct caacaaaagg tgaatgagtg tgttaaatca
23941 caatcaaatc ggtttggttt ttgtggcaat ggtacacatt tgttttccat tgttaacaat
24001 gcacctaatg gtttgatgtt tttccatacc gttttagttc ctactgttta cgtcacagtt
24061 tctgcatggg ctggtgtttg ttttaataac cgtgcgtaca ttcttagaga tgttgagagt
24121 gtgcttttta ataataacgg ttattatgtc actaacagga agatgtatga accacgtgtt
24181 cctcagttct ccgactttgt gcaagttgag aattgtgttg tgtcttattt gaatctttct
24241 gatgttgatg ttaacactgt aatacctgat tacatagatg ttaacaaaac tctagaggat
24301 ttgttacaac agttaccaaa tcacacactt cctgaccttg gcctagatca gtataataat
24361 acaattttaa acttgacagc tgaaatagac attttacaga acaagtctga cttgttgttg
24421 gcatctactg aaaggttgca acaacttatt gataacctca ataagacgta tgtggactta
24481 gagtggctta atagatttga acagtacatt aagtggcctt ggtatgtgtg gttggcaatt
24541 ttgcttgcca tcatactatt ctcatttttg atgttatatt gttgttgtgc cactggttgt
24601 tgtggttgtc ttagctgttt gaccaattct tgtgattgtc gcggcaaaaa tttacaacgt
24661 tacgaagtag aaaaagtgca cattcaataa tgactggcct atttcaaacc tcttttggtg
24721 actcagttca ggctggtgtg cagcatttag ttgaaaaatt accattacct gatgtacatt
24781 ttcaacatgc attgccatta gccaattttc tcatgactag tgtgtttgta atttactttg
24841 ctatgtacaa agccagctca gttagaaata actgtattat gtttggcttt aggctttttg
24901 caatgtttgt atacgcacca ttgttatgtt attttgagct gtatgttgat gccgctatta
24961 ttttcggtgc tctttacact aggcttatgt atgttacgta ttatgcctgt aggtacagat
25021 cacctgcatt tgttgtgctt aacactgaca aacttgcttt tgttcaaggc tattattggt
25081 actatcagga caactcatac ctgactttgt taggtggtga aaactttgtc acctttggtc
25141 ctaattttgt gccaattgct gccactaatg acctttacat tgctctcaga ggtaagaaag
25201 atgatgatgt accactggtg aggcgcgtag aactcatcaa tggacaattc ttttacatct
25261 ttgcacaaga gcctgttgta ggtgtggtga acatgtgctt ttctgaactt agactctgtg
25321 aagaagttga agttcaatct gattaacaaa ctaaactaaa tttaacctaa caccatgatg
25381 tttacattag tgaatgataa tggtatgatt gtaagtgcaa tcctttggtt agttgtgttg
25441 ttgtttgttc tactaattgc tgttactgta attaaattaa ttcaattatg ctttacatgt
25501 cacaagctta tgagcaacac aatttatgtg cctgtttata gtgcttatgt tatgtataaa
25561 aattttatgc aaatagatcc ttgcccagtt atagatgtct aaacgaaatg tcaaacggtg
25621 acaattcaac gatacccaca gatgtggtta tccaacatct aagaaattgg aatttcagtt
25681 ggaatgtaat tcttacaata tttctagttg tccttcaata tggacactac aaatatagtg
25741 ctgtgcttta catcctgaaa atgacaattc tgtggctgct gtggcctctt gtacttgccc
25801 tgtcaatttt tgacagttgg tcaagttttg gcaacaactg gaccatgttt gcttttagca
25861 tcttaatggc ttgcattacg cttgtgctgt ggataatgta ctttgtcaac agtttcaggc
25921 tgtaccgcag aaccaacact ttctgggcct ttaacccgga aactgatgcc attatcacac
25981 tgtccgtctt tggtcgccaa gtttcaattc cagcccttgt ggctccaact ggcattacgc
26041 tcactgtgtt aagtggtaca ctcctagtgg aaggcattaa ggttgctact ggtgtgcagg
26101 taaaccaatt acctacgtac atcactgttg ccaagcctag caccacaatt gtgtatcaac
26161 gtgctggacg ttcgctcaac acgcgctcaa acacaggttg ggcgttttat gtcagatcga
26221 aaaatggcga ctactctgct gtaacgagtt ctgctgattc gcttacagaa gacgagaaac
26281 ttttacattt agtctaaact aaacaaaatg gcctcaggtg gcaacaatgt tagctttgct
26341 aacaaaccca gaggtcggag tggcaaagtc cctctatctt attattctcc tgtcatgatt
26401 gacggagatc aacccttttg gaaggtgatg cccactaatg ccgtaccaac tggcatgggt
26461 gacaaaaatc aacaaattgg ctattggaat gaacaacccc gttggagaat ggtcaaaggc
26521 cagcgtaagg agttgccgtc taagtggcac ttttattacc ttggtactgg accacaagaa
26581 gatgcacgct atcgtcaaag aattgaaggt gtgttttggg ttgctgtaca gggttcaaag
26641 actgatccta ccggcttggg aactcgcagg aagggtcagg atctgatctc acctaaattt
26701 gctgttaaaa ttccttccaa tgtgatgatt gtagaggaaa cctctcgccc tccttctaga
26761 tcacaaagta acagcaggcc tcagagcaga aacaactcta ggcctcaatc taaaaataac
26821 tctcagaaca actctcgtga caactcgaga gcaccaagca gacctcgttc acgcgcaaat
26881 tcaactagct ctaccactaa tgatgctgtt gatattgttg ctgccgtgaa acaagcgctt
26941 aaagagcttg gtgtaacacc tgagaagaaa aatcaagaaa aacaaaagaa aagcaagaaa
27001 agcaattctg gtagcaacac cccaaaagag gctgccactc caaaacaaaa atctagccct
27061 tcaacaccaa ggaagcagct agaaagacca gagtggaaac gtgtgccaaa caaggaggaa
27121 aatgttactg cttgttttgg accacgagac actcttcaca acttcggtga tcaaaagctt
27181 attgctgaag gtgtgcaagc ttctcattat ccccaactcg ctgaactcgt acctacacca
27241 gctgcattgc tgtttggtgg cgaagtttca acgagagaac gtggtgatga agttgaaatt
27301 atgtatgttt acaaaatgaa ggttcacaaa tcaaacaagg accttcctgc tttcttgcaa
27361 caagtcagtg cttatgctca agctcctgat gctacaacta cagaaaaagc tactgtgcaa
27421 ccactgctga atccaactgc tccagacttc caaccagcta catcggaaga agtcattgaa
27481 atgattaaca ctgtgtatga ttcttttgat gcgtaatcaa ctaaacaggt aatgcatgtg
27541 ctcataatta tcatctgctt ctatttgcag tgctttttgt gggcattaca acctttgttt
27601 gaggcttgcg cttatcattg gcctgtttgt gtttacgtac ctagtaccat ttcatactgt
27661 tatagtgtcc ttggatttag tcttattgta attggctgct tattttctgc tttggttctt
27721 gacgttcttg gacttattgc acttaagtgt ctgttagttt gtaggtttct taattaatca
27781 atcacaatga aattgttact gcttcttagt attcttagct tttcttctgc agccccaact
27841 acctatcggg catctcaagc tgctaaagta ctaatttata ccactgaaaa agtcactcta
27901 aataaccaga gaacacactc atacacaaaa tggggtgtgt gctccacagg atggaacaca
27961 tacacgaaca caatggttgt ggttaatggt aggtgggttg aaacaaccaa accgccaaga
28021 cccacagcca ttgctattcc aacattccca tacgagccta gaagtgaaaa accaggtttt
28081 ggttctcact ttgactatgg ccgtattgag tatgagagta tcttgtgtgc tgcatttgag
28141 catgtcagta atgacattgc aaaaattgct gctcaattgg ctcagacaca gcgacgacat
28201 cagactttcg ctgtgactac ttttaggtgg tctactcctt caaattaata cgcacccttt
28261 cttcggattg acaaggtgct actcttatac agaatggtaa gcctgtttat aagctagtat
28321 aagtagagtt tatagatatt gctgtgccta gaccaacgta catattacaa gacactccag
28381 agtcagagta atttaaagat ccgcatagac gagccaacaa tggaagagct gtcatggaat
28441 cttgtatata tgtatcagta gttgttagtg gacacggctt tgatagggat acgc
//
