LOCUS NP_001004758 323 aa linear PRI 17-FEB-2013
DEFINITION olfactory receptor 51S1 [Homo sapiens].
ACCESSION NP_001004758 XP_061624
VERSION NP_001004758.1 GI:52317154
DBSOURCE REFSEQ: accession NM_001004758.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 323)
AUTHORS Malnic,B., Godfrey,P.A. and Buck,L.B.
TITLE The human olfactory receptor gene family
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (8), 2584-2589 (2004)
PUBMED 14983052
REMARK Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AB065796.1.
On Sep 19, 2004 this sequence version replaced gi:17456789.
Summary: Olfactory receptors interact with odorant molecules in the
nose, to initiate a neuronal response that triggers the perception
of a smell. The olfactory receptor proteins are members of a large
family of G-protein-coupled receptors (GPCR) arising from single
coding-exon genes. Olfactory receptors share a 7-transmembrane
domain structure with many neurotransmitter and hormone receptors
and are responsible for the recognition and G protein-mediated
transduction of odorant signals. The olfactory receptor gene family
is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is
independent of other organisms. [provided by RefSeq, Jul 2008].
FEATURES Location/Qualifiers
source 1..323
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15.4"
Protein 1..323
/product="olfactory receptor 51S1"
/note="olfactory receptor OR11-24"
/calculated_mol_wt=35182
Site 34..54
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
variation 40
/replace="t"
/db_xref="dbSNP:139571388"
Region 44..>150
/region_name="7tm_4"
/note="Olfactory receptor; cl10458"
/db_xref="CDD:209142"
variation 52
/replace="s"
/db_xref="dbSNP:35918613"
variation 54
/replace="f"
/db_xref="dbSNP:200206720"
Region 55..299
/region_name="7tm_1"
/note="7 transmembrane receptor (rhodopsin family);
pfam00001"
/db_xref="CDD:200918"
variation 57
/replace="n"
/db_xref="dbSNP:12417164"
variation 58
/replace="v"
/db_xref="dbSNP:148022689"
variation 60
/replace="e"
/db_xref="dbSNP:11602499"
Site 63..83
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
variation 82
/replace="d"
/db_xref="dbSNP:200985283"
variation 93
/replace="t"
/db_xref="dbSNP:148053298"
variation 95
/replace="t"
/db_xref="dbSNP:143553379"
variation 101
/replace="s"
/db_xref="dbSNP:146829053"
Site 108..128
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
variation 108
/replace="r"
/db_xref="dbSNP:145052637"
variation 123
/replace="f"
/db_xref="dbSNP:115775855"
variation 130
/replace="w"
/db_xref="dbSNP:139421041"
variation 135
/replace="w"
/db_xref="dbSNP:149309964"
variation 136
/replace="*"
/db_xref="dbSNP:199897048"
variation 136
/replace="q"
/db_xref="dbSNP:151316061"
Site 148..168
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
variation 153
/replace="r"
/db_xref="dbSNP:200906976"
variation 159
/replace="*"
/db_xref="dbSNP:200652284"
Region 175..292
/region_name="7tm_4"
/note="Olfactory receptor; pfam13853"
/db_xref="CDD:206024"
variation 178
/replace="r"
/db_xref="dbSNP:7117260"
variation 186
/replace="c"
/db_xref="dbSNP:77762264"
variation 194
/replace="c"
/db_xref="dbSNP:142743963"
variation 195
/replace="f"
/db_xref="dbSNP:80199695"
Site 204..224
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
variation 216
/replace="s"
/db_xref="dbSNP:57238061"
variation 225
/replace="c"
/db_xref="dbSNP:143884421"
variation 241
/replace="g"
/db_xref="dbSNP:115882083"
variation 241
/replace="l"
/db_xref="dbSNP:138092000"
Site 245..265
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
variation 261
/replace="t"
/db_xref="dbSNP:113028061"
variation 264
/replace="f"
/db_xref="dbSNP:12361955"
variation 278
/replace="r"
/db_xref="dbSNP:138651833"
variation 280
/replace="p"
/db_xref="dbSNP:145071132"
Site 281..301
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
variation 286
/replace="g"
/db_xref="dbSNP:200928180"
variation 311
/replace="v"
/db_xref="dbSNP:112869374"
variation 313
/replace="k"
/db_xref="dbSNP:200546421"
variation 314
/replace="f"
/db_xref="dbSNP:201227813"
variation 319
/replace="a"
/db_xref="dbSNP:148105520"
CDS 1..323
/gene="OR51S1"
/gene_synonym="OR11-24"
/coded_by="NM_001004758.1:1..972"
/db_xref="CCDS:CCDS31362.1"
/db_xref="GeneID:119692"
/db_xref="HGNC:15204"
/db_xref="HPRD:17739"
ORIGIN
1 mstlptqiap nsstsmaptf llvgmpglsg apswwtlpli avyllsalgn gtilwiialq
61 palhrpmhff lfllsvsdig lvtalmptll gialagahtv pasacllqmv fihvfsvmes
121 svllamsidr alaicrplhy palltngvis kislaisfrc lglhlplpfl laympyclpq
181 vlthsyclhp dvarlacpea wgaayslfvv lsamgldpll iffsygligk vlqgvesred
241 rwkagqtcaa hlsavllfyi pmillalinh pelpitqhth tllsyvhfll pplinpilys
301 vkmkeirkri lnrlqprkvg gaq
//
