GenomeNet

Database: RefSeq
Entry: NP_001004758
LinkDB: NP_001004758
Original site: NP_001004758 
LOCUS       NP_001004758             323 aa            linear   PRI 18-JAN-2014
DEFINITION  olfactory receptor 51S1 [Homo sapiens].
ACCESSION   NP_001004758 XP_061624
VERSION     NP_001004758.1  GI:52317154
DBSOURCE    REFSEQ: accession NM_001004758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 323)
  AUTHORS   Malnic B, Godfrey PA and Buck LB.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB065796.1.
            On Sep 19, 2004 this sequence version replaced gi:17456789.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. The nomenclature assigned to the
            olfactory receptor genes and proteins for this organism is
            independent of other organisms. [provided by RefSeq, Jul 2008].
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     Protein         1..323
                     /product="olfactory receptor 51S1"
                     /note="olfactory receptor OR11-24"
                     /calculated_mol_wt=35182
     variation       13
                     /replace="g"
                     /db_xref="dbSNP:376921733"
     variation       17
                     /replace="v"
                     /db_xref="dbSNP:373477933"
     variation       22
                     /replace="l"
                     /db_xref="dbSNP:370057466"
     variation       24
                     /replace="g"
                     /db_xref="dbSNP:202097083"
     variation       26
                     /replace="l"
                     /db_xref="dbSNP:375695111"
     variation       32
                     /replace="p"
                     /db_xref="dbSNP:143178206"
     Site            34..54
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       40
                     /replace="t"
                     /db_xref="dbSNP:139571388"
     variation       47
                     /replace="a"
                     /db_xref="dbSNP:11601065"
     Region          49..>179
                     /region_name="7TM_GPCR_Srsx"
                     /note="Serpentine type 7TM GPCR chemoreceptor Srsx;
                     pfam10320"
                     /db_xref="CDD:255903"
     variation       52
                     /replace="s"
                     /db_xref="dbSNP:35918613"
     variation       54
                     /replace="f"
                     /db_xref="dbSNP:200206720"
     Region          55..299
                     /region_name="7tm_1"
                     /note="7 transmembrane receptor (rhodopsin family);
                     pfam00001"
                     /db_xref="CDD:249497"
     variation       56
                     /replace="i"
                     /db_xref="dbSNP:146540688"
     variation       57
                     /replace="n"
                     /db_xref="dbSNP:12417164"
     variation       58
                     /replace="v"
                     /db_xref="dbSNP:148022689"
     variation       60
                     /replace="e"
                     /db_xref="dbSNP:11602499"
     Site            63..83
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       65
                     /replace="c"
                     /db_xref="dbSNP:369275172"
     variation       82
                     /replace="d"
                     /db_xref="dbSNP:200985283"
     variation       84
                     /replace="g"
                     /db_xref="dbSNP:376299030"
     variation       88
                     /replace="i"
                     /db_xref="dbSNP:373088155"
     variation       91
                     /replace="g"
                     /db_xref="dbSNP:369896989"
     variation       92
                     /replace="i"
                     /db_xref="dbSNP:141795519"
     variation       93
                     /replace="t"
                     /db_xref="dbSNP:148053298"
     variation       95
                     /replace="t"
                     /db_xref="dbSNP:143553379"
     variation       100
                     /replace="v"
                     /db_xref="dbSNP:11602455"
     variation       101
                     /replace="s"
                     /db_xref="dbSNP:146829053"
     variation       106
                     /replace="l"
                     /db_xref="dbSNP:377187372"
     Site            108..128
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       108
                     /replace="q"
                     /db_xref="dbSNP:372829309"
     variation       108
                     /replace="r"
                     /db_xref="dbSNP:145052637"
     variation       123
                     /replace="f"
                     /db_xref="dbSNP:115775855"
     variation       124
                     /replace="l"
                     /db_xref="dbSNP:145177947"
     variation       125
                     /replace="a"
                     /db_xref="dbSNP:143546045"
     variation       130
                     /replace="w"
                     /db_xref="dbSNP:139421041"
     variation       133
                     /replace="d"
                     /db_xref="dbSNP:367556326"
     variation       135
                     /replace="w"
                     /db_xref="dbSNP:149309964"
     variation       136
                     /replace="*"
                     /db_xref="dbSNP:199897048"
     variation       136
                     /replace="q"
                     /db_xref="dbSNP:151316061"
     variation       139
                     /replace="y"
                     /db_xref="dbSNP:376602346"
     variation       146
                     /replace="n"
                     /db_xref="dbSNP:371928799"
     Site            148..168
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       149
                     /replace="i"
                     /db_xref="dbSNP:7117389"
     Region          152..292
                     /region_name="7tm_4"
                     /note="Olfactory receptor; pfam13853"
                     /db_xref="CDD:258124"
     variation       153
                     /replace="r"
                     /db_xref="dbSNP:200906976"
     variation       159
                     /replace="*"
                     /db_xref="dbSNP:200652284"
     variation       160
                     /replace="c"
                     /db_xref="dbSNP:140920607"
     variation       178
                     /replace="r"
                     /db_xref="dbSNP:7117260"
     variation       186
                     /replace="c"
                     /db_xref="dbSNP:77762264"
     variation       194
                     /replace="c"
                     /db_xref="dbSNP:142743963"
     variation       195
                     /replace="l"
                     /db_xref="dbSNP:80199695"
     variation       202
                     /replace="s"
                     /db_xref="dbSNP:374902371"
     Site            204..224
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       209
                     /replace="a"
                     /db_xref="dbSNP:371893114"
     variation       216
                     /replace="s"
                     /db_xref="dbSNP:57238061"
     variation       225
                     /replace="c"
                     /db_xref="dbSNP:143884421"
     variation       241
                     /replace="g"
                     /db_xref="dbSNP:115882083"
     variation       241
                     /replace="l"
                     /db_xref="dbSNP:138092000"
     Site            245..265
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       257
                     /replace="l"
                     /db_xref="dbSNP:200387383"
     variation       260
                     /replace="n"
                     /db_xref="dbSNP:368393494"
     variation       261
                     /replace="t"
                     /db_xref="dbSNP:113028061"
     variation       263
                     /replace="i"
                     /db_xref="dbSNP:144561381"
     variation       264
                     /replace="f"
                     /db_xref="dbSNP:12361955"
     variation       278
                     /replace="r"
                     /db_xref="dbSNP:138651833"
     variation       280
                     /replace="p"
                     /db_xref="dbSNP:145071132"
     Site            281..301
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       286
                     /replace="g"
                     /db_xref="dbSNP:200928180"
     variation       298
                     /replace="l"
                     /db_xref="dbSNP:373804534"
     variation       311
                     /replace="v"
                     /db_xref="dbSNP:112869374"
     variation       313
                     /replace="k"
                     /db_xref="dbSNP:200546421"
     variation       314
                     /replace="f"
                     /db_xref="dbSNP:201227813"
     variation       319
                     /replace="a"
                     /db_xref="dbSNP:148105520"
     CDS             1..323
                     /gene="OR51S1"
                     /gene_synonym="OR11-24"
                     /coded_by="NM_001004758.1:1..972"
                     /db_xref="CCDS:CCDS31362.1"
                     /db_xref="GeneID:119692"
                     /db_xref="HGNC:HGNC:15204"
                     /db_xref="HPRD:17739"
ORIGIN      
        1 mstlptqiap nsstsmaptf llvgmpglsg apswwtlpli avyllsalgn gtilwiialq
       61 palhrpmhff lfllsvsdig lvtalmptll gialagahtv pasacllqmv fihvfsvmes
      121 svllamsidr alaicrplhy palltngvis kislaisfrc lglhlplpfl laympyclpq
      181 vlthsyclhp dvarlacpea wgaayslfvv lsamgldpll iffsygligk vlqgvesred
      241 rwkagqtcaa hlsavllfyi pmillalinh pelpitqhth tllsyvhfll pplinpilys
      301 vkmkeirkri lnrlqprkvg gaq
//
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