GenomeNet

Database: RefSeq
Entry: NP_001004758
LinkDB: NP_001004758
Original site: NP_001004758 
LOCUS       NP_001004758             323 aa            linear   PRI 18-JAN-2014
DEFINITION  olfactory receptor 51S1 [Homo sapiens].
ACCESSION   NP_001004758 XP_061624
VERSION     NP_001004758.1  GI:52317154
DBSOURCE    REFSEQ: accession NM_001004758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 323)
  AUTHORS   Malnic B, Godfrey PA and Buck LB.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB065796.1.
            On Sep 19, 2004 this sequence version replaced gi:17456789.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. The nomenclature assigned to the
            olfactory receptor genes and proteins for this organism is
            independent of other organisms. [provided by RefSeq, Jul 2008].
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     Protein         1..323
                     /product="olfactory receptor 51S1"
                     /note="olfactory receptor OR11-24"
                     /calculated_mol_wt=35182
     variation       3
                     /replace="a"
                     /db_xref="dbSNP:749531920"
     variation       7
                     /replace="e"
                     /db_xref="dbSNP:775910445"
     variation       8
                     /replace="r"
                     /db_xref="dbSNP:770275280"
     variation       9
                     /replace="a"
                     /db_xref="dbSNP:781506849"
     variation       9
                     /replace="v"
                     /db_xref="dbSNP:576440517"
     variation       10
                     /replace="l"
                     /db_xref="dbSNP:757816643"
     variation       10
                     /replace="p"
                     /db_xref="dbSNP:747547530"
     variation       11
                     /replace="i"
                     /db_xref="dbSNP:753324111"
     variation       13
                     /replace="g"
                     /db_xref="dbSNP:376921733"
     variation       17
                     /replace="a"
                     /db_xref="dbSNP:766060488"
     variation       17
                     /replace="t"
                     /db_xref="dbSNP:754542087"
     variation       17
                     /replace="v"
                     /db_xref="dbSNP:373477933"
     variation       22
                     /replace="l"
                     /db_xref="dbSNP:370057466"
     variation       24
                     /replace="g"
                     /db_xref="dbSNP:202097083"
     variation       25
                     /replace="i"
                     /db_xref="dbSNP:767316024"
     variation       26
                     /replace="l"
                     /db_xref="dbSNP:375695111"
     variation       26
                     /replace="p"
                     /db_xref="dbSNP:775649547"
     variation       26
                     /replace="s"
                     /db_xref="dbSNP:761813182"
     variation       29
                     /replace="p"
                     /db_xref="dbSNP:763187476"
     variation       30
                     /replace="v"
                     /db_xref="dbSNP:775820579"
     variation       32
                     /replace="h"
                     /db_xref="dbSNP:770166893"
     variation       32
                     /replace="p"
                     /db_xref="dbSNP:143178206"
     variation       33
                     /replace="a"
                     /db_xref="dbSNP:535844795"
     Site            34..54
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       36
                     /replace="t"
                     /db_xref="dbSNP:572013948"
     variation       40
                     /replace="t"
                     /db_xref="dbSNP:139571388"
     variation       42
                     /replace="i"
                     /db_xref="dbSNP:768124355"
     variation       46
                     /replace="c"
                     /db_xref="dbSNP:765964791"
     variation       46
                     /replace="p"
                     /db_xref="dbSNP:748846954"
     variation       47
                     /replace="a"
                     /db_xref="dbSNP:11601065"
     Region          49..>179
                     /region_name="7tm_4"
                     /note="Olfactory receptor; cl21561"
                     /db_xref="CDD:277551"
     variation       50
                     /replace="s"
                     /db_xref="dbSNP:755793807"
     variation       52
                     /replace="s"
                     /db_xref="dbSNP:35918613"
     variation       53
                     /replace="i"
                     /db_xref="dbSNP:757054940"
     variation       53
                     /replace="l"
                     /db_xref="dbSNP:781052835"
     variation       54
                     /replace="f"
                     /db_xref="dbSNP:200206720"
     Region          55..299
                     /region_name="7tm_1"
                     /note="7 transmembrane receptor (rhodopsin family);
                     pfam00001"
                     /db_xref="CDD:249497"
     variation       56
                     /replace="i"
                     /db_xref="dbSNP:146540688"
     variation       57
                     /replace="n"
                     /db_xref="dbSNP:12417164"
     variation       58
                     /replace="v"
                     /db_xref="dbSNP:148022689"
     variation       60
                     /replace="e"
                     /db_xref="dbSNP:11602499"
     variation       61
                     /replace="p"
                     /db_xref="dbSNP:765491390"
     variation       62
                     /replace="t"
                     /db_xref="dbSNP:527640209"
     Site            63..83
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       63
                     /replace="l"
                     /db_xref="dbSNP:760985899"
     variation       65
                     /replace="c"
                     /db_xref="dbSNP:369275172"
     variation       65
                     /replace="h"
                     /db_xref="dbSNP:560546339"
     variation       65
                     /replace="r"
                     /db_xref="dbSNP:748756937"
     variation       74
                     /replace="h"
                     /db_xref="dbSNP:779541982"
     variation       75
                     /replace="r"
                     /db_xref="dbSNP:769272480"
     variation       77
                     /replace="p"
                     /db_xref="dbSNP:745518684"
     variation       80
                     /replace="e"
                     /db_xref="dbSNP:757042763"
     variation       80
                     /replace="r"
                     /db_xref="dbSNP:780772268"
     variation       81
                     /replace="l"
                     /db_xref="dbSNP:751356202"
     variation       82
                     /replace="d"
                     /db_xref="dbSNP:200985283"
     variation       84
                     /replace="g"
                     /db_xref="dbSNP:376299030"
     variation       88
                     /replace="i"
                     /db_xref="dbSNP:373088155"
     variation       88
                     /replace="t"
                     /db_xref="dbSNP:758419074"
     variation       90
                     /replace="l"
                     /db_xref="dbSNP:752769014"
     variation       91
                     /replace="d"
                     /db_xref="dbSNP:765396958"
     variation       91
                     /replace="g"
                     /db_xref="dbSNP:369896989"
     variation       92
                     /replace="i"
                     /db_xref="dbSNP:141795519"
     variation       93
                     /replace="s"
                     /db_xref="dbSNP:148053298"
     variation       94
                     /replace="f"
                     /db_xref="dbSNP:571339830"
     variation       95
                     /replace="s"
                     /db_xref="dbSNP:143553379"
     variation       96
                     /replace="a"
                     /db_xref="dbSNP:767944836"
     variation       97
                     /replace="d"
                     /db_xref="dbSNP:762319949"
     variation       99
                     /replace="m"
                     /db_xref="dbSNP:760310390"
     variation       100
                     /replace="v"
                     /db_xref="dbSNP:11602455"
     variation       101
                     /replace="s"
                     /db_xref="dbSNP:146829053"
     variation       102
                     /replace="v"
                     /db_xref="dbSNP:745408322"
     variation       104
                     /replace="v"
                     /db_xref="dbSNP:776320504"
     variation       105
                     /replace="y"
                     /db_xref="dbSNP:770509199"
     variation       106
                     /replace="f"
                     /db_xref="dbSNP:773061814"
     variation       106
                     /replace="l"
                     /db_xref="dbSNP:377187372"
     Site            108..128
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       108
                     /replace="q"
                     /db_xref="dbSNP:372829309"
     variation       108
                     /replace="r"
                     /db_xref="dbSNP:145052637"
     variation       109
                     /replace="l"
                     /db_xref="dbSNP:758328852"
     variation       111
                     /replace="f"
                     /db_xref="dbSNP:748095209"
     variation       112
                     /replace="i"
                     /db_xref="dbSNP:779036228"
     variation       113
                     /replace="l"
                     /db_xref="dbSNP:561122104"
     variation       114
                     /replace="c"
                     /db_xref="dbSNP:771827294"
     variation       115
                     /replace="s"
                     /db_xref="dbSNP:753887408"
     variation       123
                     /replace="f"
                     /db_xref="dbSNP:115775855"
     variation       124
                     /replace="l"
                     /db_xref="dbSNP:145177947"
     variation       125
                     /replace="a"
                     /db_xref="dbSNP:143546045"
     variation       125
                     /replace="t"
                     /db_xref="dbSNP:750726928"
     variation       126
                     /replace="i"
                     /db_xref="dbSNP:774806690"
     variation       129
                     /replace="e"
                     /db_xref="dbSNP:764553647"
     variation       130
                     /replace="w"
                     /db_xref="dbSNP:139421041"
     variation       131
                     /replace="a"
                     /db_xref="dbSNP:776012481"
     variation       131
                     /replace="h"
                     /db_xref="dbSNP:775254222"
     variation       133
                     /replace="d"
                     /db_xref="dbSNP:367556326"
     variation       135
                     /replace="w"
                     /db_xref="dbSNP:149309964"
     variation       136
                     /replace="*"
                     /db_xref="dbSNP:199897048"
     variation       136
                     /replace="q"
                     /db_xref="dbSNP:151316061"
     variation       136
                     /replace="r"
                     /db_xref="dbSNP:748007815"
     variation       139
                     /replace="h"
                     /db_xref="dbSNP:754904389"
     variation       139
                     /replace="y"
                     /db_xref="dbSNP:376602346"
     variation       140
                     /replace="h"
                     /db_xref="dbSNP:749323041"
     variation       140
                     /replace="s"
                     /db_xref="dbSNP:780011740"
     variation       142
                     /replace="t"
                     /db_xref="dbSNP:756241912"
     variation       142
                     /replace="v"
                     /db_xref="dbSNP:750637821"
     variation       143
                     /replace="r"
                     /db_xref="dbSNP:767764181"
     variation       144
                     /replace="f"
                     /db_xref="dbSNP:757594137"
     variation       144
                     /replace="l"
                     /db_xref="dbSNP:544753688"
     variation       146
                     /replace="n"
                     /db_xref="dbSNP:371928799"
     Site            148..168
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       149
                     /replace="i"
                     /db_xref="dbSNP:7117389"
     variation       150
                     /replace="n"
                     /db_xref="dbSNP:753309591"
     variation       151
                     /replace="n"
                     /db_xref="dbSNP:765805950"
     Region          152..292
                     /region_name="7tm_4"
                     /note="Olfactory receptor; pfam13853"
                     /db_xref="CDD:258124"
     variation       153
                     /replace="r"
                     /db_xref="dbSNP:200906976"
     variation       156
                     /replace="v"
                     /db_xref="dbSNP:772978601"
     variation       158
                     /replace="f"
                     /db_xref="dbSNP:771873712"
     variation       159
                     /replace="*"
                     /db_xref="dbSNP:200652284"
     variation       159
                     /replace="q"
                     /db_xref="dbSNP:538018962"
     variation       160
                     /replace="c"
                     /db_xref="dbSNP:140920607"
     variation       160
                     /replace="f"
                     /db_xref="dbSNP:768579248"
     variation       162
                     /replace="v"
                     /db_xref="dbSNP:780106210"
     variation       163
                     /replace="f"
                     /db_xref="dbSNP:769830257"
     variation       165
                     /replace="l"
                     /db_xref="dbSNP:745993003"
     variation       169
                     /replace="l"
                     /db_xref="dbSNP:781340870"
     variation       174
                     /replace="i"
                     /db_xref="dbSNP:757499584"
     variation       175
                     /replace="t"
                     /db_xref="dbSNP:751897505"
     variation       177
                     /replace="y"
                     /db_xref="dbSNP:777988587"
     variation       178
                     /replace="f"
                     /db_xref="dbSNP:758868363"
     variation       178
                     /replace="h"
                     /db_xref="dbSNP:7117260"
     variation       183
                     /replace="a"
                     /db_xref="dbSNP:760213449"
     variation       185
                     /replace="f"
                     /db_xref="dbSNP:749986551"
     variation       186
                     /replace="c"
                     /db_xref="dbSNP:77762264"
     variation       188
                     /replace="f"
                     /db_xref="dbSNP:761569065"
     variation       190
                     /replace="l"
                     /db_xref="dbSNP:774109291"
     variation       193
                     /replace="d"
                     /db_xref="dbSNP:762845476"
     variation       194
                     /replace="c"
                     /db_xref="dbSNP:142743963"
     variation       194
                     /replace="h"
                     /db_xref="dbSNP:745906078"
     variation       194
                     /replace="r"
                     /db_xref="dbSNP:781250179"
     variation       195
                     /replace="f"
                     /db_xref="dbSNP:80199695"
     variation       197
                     /replace="*"
                     /db_xref="dbSNP:771058907"
     variation       198
                     /replace="a"
                     /db_xref="dbSNP:747194046"
     variation       200
                     /replace="a"
                     /db_xref="dbSNP:778101606"
     variation       201
                     /replace="*"
                     /db_xref="dbSNP:758672297"
     variation       202
                     /replace="g"
                     /db_xref="dbSNP:779524023"
     variation       202
                     /replace="s"
                     /db_xref="dbSNP:374902371"
     Site            204..224
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       204
                     /replace="v"
                     /db_xref="dbSNP:755548661"
     variation       205
                     /replace="c"
                     /db_xref="dbSNP:749894455"
     variation       207
                     /replace="l"
                     /db_xref="dbSNP:767120829"
     variation       207
                     /replace="r"
                     /db_xref="dbSNP:756858870"
     variation       208
                     /replace="c"
                     /db_xref="dbSNP:751139569"
     variation       208
                     /replace="f"
                     /db_xref="dbSNP:763853085"
     variation       209
                     /replace="a"
                     /db_xref="dbSNP:371893114"
     variation       209
                     /replace="v"
                     /db_xref="dbSNP:775384301"
     variation       210
                     /replace="v"
                     /db_xref="dbSNP:534549264"
     variation       213
                     /replace="s"
                     /db_xref="dbSNP:561747618"
     variation       214
                     /replace="v"
                     /db_xref="dbSNP:776619784"
     variation       215
                     /replace="g"
                     /db_xref="dbSNP:770970958"
     variation       216
                     /replace="s"
                     /db_xref="dbSNP:57238061"
     variation       217
                     /replace="e"
                     /db_xref="dbSNP:773260345"
     variation       218
                     /replace="p"
                     /db_xref="dbSNP:551788843"
     variation       222
                     /replace="c"
                     /db_xref="dbSNP:748395966"
     variation       225
                     /replace="c"
                     /db_xref="dbSNP:143884421"
     variation       226
                     /replace="g"
                     /db_xref="dbSNP:533188649"
     variation       228
                     /replace="n"
                     /db_xref="dbSNP:780747079"
     variation       229
                     /replace="g"
                     /db_xref="dbSNP:756698701"
     variation       231
                     /replace="l"
                     /db_xref="dbSNP:751099845"
     variation       232
                     /replace="w"
                     /db_xref="dbSNP:774175084"
     variation       233
                     /replace="k"
                     /db_xref="dbSNP:763610189"
     variation       233
                     /replace="p"
                     /db_xref="dbSNP:758072053"
     variation       234
                     /replace="s"
                     /db_xref="dbSNP:752429033"
     variation       238
                     /replace="r"
                     /db_xref="dbSNP:765015135"
     variation       241
                     /replace="g"
                     /db_xref="dbSNP:115882083"
     variation       241
                     /replace="l"
                     /db_xref="dbSNP:138092000"
     variation       243
                     /replace="e"
                     /db_xref="dbSNP:773348022"
     variation       244
                     /replace="p"
                     /db_xref="dbSNP:772128367"
     variation       244
                     /replace="v"
                     /db_xref="dbSNP:748388421"
     Site            245..265
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       250
                     /replace="a"
                     /db_xref="dbSNP:774779619"
     variation       255
                     /replace="a"
                     /db_xref="dbSNP:769111593"
     variation       255
                     /replace="v"
                     /db_xref="dbSNP:749718779"
     variation       256
                     /replace="l"
                     /db_xref="dbSNP:780655263"
     variation       257
                     /replace="l"
                     /db_xref="dbSNP:200387383"
     variation       260
                     /replace="n"
                     /db_xref="dbSNP:368393494"
     variation       261
                     /replace="t"
                     /db_xref="dbSNP:113028061"
     variation       262
                     /replace="i"
                     /db_xref="dbSNP:752318585"
     variation       262
                     /replace="t"
                     /db_xref="dbSNP:757916167"
     variation       263
                     /replace="i"
                     /db_xref="dbSNP:144561381"
     variation       263
                     /replace="v"
                     /db_xref="dbSNP:778589462"
     variation       264
                     /replace="f"
                     /db_xref="dbSNP:12361955"
     variation       265
                     /replace="l"
                     /db_xref="dbSNP:554479689"
     variation       266
                     /replace="p"
                     /db_xref="dbSNP:766163611"
     variation       266
                     /replace="v"
                     /db_xref="dbSNP:760676788"
     variation       267
                     /replace="l"
                     /db_xref="dbSNP:542556778"
     variation       270
                     /replace="n"
                     /db_xref="dbSNP:762022613"
     variation       272
                     /replace="k"
                     /db_xref="dbSNP:774692080"
     variation       273
                     /replace="l"
                     /db_xref="dbSNP:763366600"
     variation       274
                     /replace="l"
                     /db_xref="dbSNP:775998313"
     variation       275
                     /replace="v"
                     /db_xref="dbSNP:770139423"
     variation       278
                     /replace="r"
                     /db_xref="dbSNP:138651833"
     variation       279
                     /replace="a"
                     /db_xref="dbSNP:781593010"
     variation       279
                     /replace="i"
                     /db_xref="dbSNP:771591301"
     variation       280
                     /replace="h"
                     /db_xref="dbSNP:778501355"
     variation       280
                     /replace="p"
                     /db_xref="dbSNP:145071132"
     Site            281..301
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NGJ8.1)"
     variation       282
                     /replace="-"
                     /db_xref="dbSNP:768595584"
     variation       282
                     /replace="f"
                     /db_xref="dbSNP:754630263"
     variation       282
                     /replace="l"
                     /db_xref="dbSNP:779888533"
     variation       282
                     /replace="p"
                     /db_xref="dbSNP:753572804"
     variation       284
                     /replace="f"
                     /db_xref="dbSNP:755927864"
     variation       284
                     /replace="s"
                     /db_xref="dbSNP:750342678"
     variation       285
                     /replace="c"
                     /db_xref="dbSNP:767403821"
     variation       285
                     /replace="y"
                     /db_xref="dbSNP:761934961"
     variation       286
                     /replace="g"
                     /db_xref="dbSNP:200928180"
     variation       287
                     /replace="d"
                     /db_xref="dbSNP:763278327"
     variation       290
                     /replace="f"
                     /db_xref="dbSNP:764615650"
     variation       291
                     /replace="p"
                     /db_xref="dbSNP:565825958"
     variation       292
                     /replace="a"
                     /db_xref="dbSNP:759870307"
     variation       292
                     /replace="p"
                     /db_xref="dbSNP:777151206"
     variation       298
                     /replace="l"
                     /db_xref="dbSNP:373804534"
     variation       300
                     /replace="n"
                     /db_xref="dbSNP:771463418"
     variation       301
                     /replace="v"
                     /db_xref="dbSNP:747591825"
     variation       302
                     /replace="r"
                     /db_xref="dbSNP:778409299"
     variation       308
                     /replace="q"
                     /db_xref="dbSNP:558673376"
     variation       311
                     /replace="r"
                     /db_xref="dbSNP:748936962"
     variation       311
                     /replace="v"
                     /db_xref="dbSNP:112869374"
     variation       312
                     /replace="s"
                     /db_xref="dbSNP:779610861"
     variation       313
                     /replace="g"
                     /db_xref="dbSNP:560507608"
     variation       313
                     /replace="k"
                     /db_xref="dbSNP:200546421"
     variation       314
                     /replace="f"
                     /db_xref="dbSNP:201227813"
     variation       314
                     /replace="l"
                     /db_xref="dbSNP:745671659"
     variation       315
                     /replace="h"
                     /db_xref="dbSNP:757261474"
     variation       319
                     /replace="a"
                     /db_xref="dbSNP:148105520"
     variation       319
                     /replace="l"
                     /db_xref="dbSNP:764252300"
     variation       323
                     /replace="r"
                     /db_xref="dbSNP:752943873"
     CDS             1..323
                     /gene="OR51S1"
                     /gene_synonym="OR11-24"
                     /coded_by="NM_001004758.1:1..972"
                     /db_xref="CCDS:CCDS31362.1"
                     /db_xref="GeneID:119692"
                     /db_xref="HGNC:HGNC:15204"
                     /db_xref="HPRD:17739"
ORIGIN      
        1 mstlptqiap nsstsmaptf llvgmpglsg apswwtlpli avyllsalgn gtilwiialq
       61 palhrpmhff lfllsvsdig lvtalmptll gialagahtv pasacllqmv fihvfsvmes
      121 svllamsidr alaicrplhy palltngvis kislaisfrc lglhlplpfl laympyclpq
      181 vlthsyclhp dvarlacpea wgaayslfvv lsamgldpll iffsygligk vlqgvesred
      241 rwkagqtcaa hlsavllfyi pmillalinh pelpitqhth tllsyvhfll pplinpilys
      301 vkmkeirkri lnrlqprkvg gaq
//
DBGET integrated database retrieval system