LOCUS NP_001081597 955 aa linear VRT 22-MAY-2022
DEFINITION thrombospondin-4 precursor [Xenopus laevis].
ACCESSION NP_001081597 NP_001081598
VERSION NP_001081597.1
DBSOURCE REFSEQ: accession NM_001088128.1
KEYWORDS RefSeq.
SOURCE Xenopus laevis (African clawed frog)
ORGANISM Xenopus laevis
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
Xenopus; Xenopus.
REFERENCE 1 (residues 1 to 955)
AUTHORS Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
Richardson P.
TITLE Genetic and genomic tools for Xenopus research: The NIH Xenopus
initiative
JOURNAL Dev Dyn 225 (4), 384-391 (2002)
PUBMED 12454917
REFERENCE 2 (residues 1 to 955)
AUTHORS Lawler J, Duquette M, Whittaker CA, Adams JC, McHenry K and
DeSimone DW.
TITLE Identification and characterization of thrombospondin-4, a new
member of the thrombospondin gene family
JOURNAL J Cell Biol 120 (4), 1059-1067 (1993)
PUBMED 8432726
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from Z19091.1.
On Jul 25, 2007 this sequence version replaced NP_001081598.1.
##Evidence-Data-START##
Transcript exon combination :: Z19091.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00012418, SAMD00012419
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..955
/organism="Xenopus laevis"
/db_xref="taxon:8355"
/chromosome="1L"
/map="1L"
Protein 1..955
/product="thrombospondin-4 precursor"
/note="thrombospondin-4"
/calculated_mol_wt=102132
sig_peptide 1..24
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2805
Region 24..192
/region_name="TSPN"
/note="Thrombospondin N-terminal -like domains;
smart00210"
/db_xref="CDD:214560"
mat_peptide 25..955
/product="thrombospondin-4"
/calculated_mol_wt=102132
Region 217..260
/region_name="coiled coil"
/note="coiled coil [structural motif]"
/db_xref="CDD:293926"
Region 217..260
/region_name="TSP-4cc"
/note="Coiled coil region of thrombospondin-4 (TSP-4);
cd16080"
/db_xref="CDD:293926"
Site order(217..222,224..229,232,234..236,238..240,242..243,
245..250,252..254,256..259)
/site_type="other"
/note="oligomer interface [polypeptide binding]"
/db_xref="CDD:293926"
Site order(228,239,242)
/site_type="other"
/note="chemical substrate binding site [chemical binding]"
/db_xref="CDD:293926"
Region 321..356
/region_name="EGF_CA"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; cd00054"
/db_xref="CDD:238011"
Site order(321,324,338)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238011"
Region 374..411
/region_name="EGF_CA"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; cd00054"
/db_xref="CDD:238011"
Site order(374,377,394)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238011"
Region 422..458
/region_name="EGF_3"
/note="EGF domain; pfam12947"
/db_xref="CDD:432893"
Region 460..492
/region_name="TSP type-3 1"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 460..492
/region_name="TSP3 repeat_short"
/note="TSP3 repeat_short [structural motif]"
/db_xref="CDD:275365"
Region 493..528
/region_name="TSP type-3 2"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 493..528
/region_name="TSP_3"
/note="Thrombospondin type 3 repeat; pfam02412"
/db_xref="CDD:367074"
Region 493..528
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275366"
Region 529..551
/region_name="TSP type-3 3"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 529..551
/region_name="TSP3 repeat_short"
/note="TSP3 repeat_short [structural motif]"
/db_xref="CDD:275366"
Region 552..587
/region_name="TSP type-3 4"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 552..587
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275366"
Region 588..610
/region_name="TSP type-3 5"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 588..610
/region_name="TSP3 repeat_short"
/note="TSP3 repeat_short [structural motif]"
/db_xref="CDD:275365"
Site 609
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q06441.1)"
Region 610..678
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 611..648
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275365"
Region 612..648
/region_name="TSP_3"
/note="Thrombospondin type 3 repeat; pfam02412"
/db_xref="CDD:367074"
Region 649..688
/region_name="TSP type-3 7"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 649..688
/region_name="TSP3 repeat_short"
/note="TSP3 repeat_short [structural motif]"
/db_xref="CDD:275366"
Region 689..724
/region_name="TSP type-3 8"
/note="propagated from UniProtKB/Swiss-Prot (Q06441.1)"
Region 689..723
/region_name="TSP_3"
/note="Thrombospondin type 3 repeat; pfam02412"
/db_xref="CDD:367074"
Region 689..720
/region_name="TSP3 repeat_long"
/note="TSP3 repeat_long [structural motif]"
/db_xref="CDD:275365"
Region 742..939
/region_name="TSP_C"
/note="Thrombospondin C-terminal region; pfam05735"
/db_xref="CDD:428609"
Site 938
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q06441.1)"
CDS 1..955
/gene="thbs4.L"
/gene_synonym="thbs4; tsp4"
/coded_by="NM_001088128.1:103..2970"
/db_xref="GeneID:397943"
/db_xref="Xenbase:XB-GENE-17336850"
ORIGIN
1 mprrkglclf lqmlllhlyg vcqaqpnyqv fdllsvsvqr qvtsflqsal snpsmnevyv
61 lstfklqpks tvtlfglyst sdnsrffeft vmgrlnkasl rylrsdgklh svffnkldia
121 dgkqhalllh lsglhrgatf aklyidcnpt gvvedlprpl sgirlntgsv hlrtlqkkgq
181 dsmdelklvm ggtlsevgai qecfmqksea gqqtgdvsrq ligqitqmnq mlgelrdvmr
241 qqvketmflr ntiaecqacg lgpdfplptk vpqrlatttp pkprcdatsc frgvrcidte
301 ggfqcgpcpe gytgngvict dvdecrlnpc flgvrcints pgfkcescpp gytgstiqgi
361 ginfakqnkq vctdtnecen grnggctsns lcintmgsfr cggckpgyvg dqikgckpek
421 scrhgqnpch asaqcseekd gdvtctcsvg wagngylcgk dtdidgypde alpcpdknck
481 kdncvyvpns gqedtdkdni gdacdedadg dgilneqdnc vlaanidqkn sdqdifgdac
541 dncrltlnnd qrdtdndgkg dacdddmdgd giknildncq rvpnvdqkdk dgdgvgdicd
601 scpdiinpnq sdidndlvgd scdtnqdsdg dghqdstdnc ptvinsnqld tdkdgigdec
661 dddddndgip dtvppgpdnc klvpnpgqed dnndgvgdvc eadfdqdtvi dridvcpena
721 eitltdfray qtvvldpegd aqidpnwivl nqgmeivqtm nsdpglavgy tafngvdfeg
781 tfhvntmtdd dyagfifgyq dsssfyvvmw kqteqtywqa tpfravaepg iqlkavksks
841 gpgehlrnal whtgdtndqv rllwkdprnv gwkdkvsyrw flqhrpqvgy irarfyegte
901 lvadsgvtvd ttmrggrlgv fcfsqeniiw snlkyrcndt ipedfqafqa qqfss
//
